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ADGRE4P Gene(Pseudogene)

Adhesion G Protein-Coupled Receptor E4, Pseudogene

GCID:
GC19M006953
GIFtS:
22
Genes Participants
UDN Logo

Aliases for ADGRE4P Gene

Aliases for ADGRE4P Gene

  • Adhesion G Protein-Coupled Receptor E4, Pseudogene 2 3 5
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 4 Pseudogene 2 3
  • G Protein-Coupled Receptor 127 2 3
  • GPR127 3 4
  • EMR4P 3 4
  • PGR16 3 4
  • EMR4 3 4
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 4 2
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 4 4
  • G-Protein Coupled Receptor PGR16 4
  • G-Protein Coupled Receptor 127 4
  • EGF-Like Module Receptor 4 4
  • EGF-TM7 Receptor EMR4 3
  • FIRE 3

External Ids for ADGRE4P Gene

Previous HGNC Symbols for ADGRE4P Gene

  • GPR127
  • EMR4
  • EMR4P

Summaries for ADGRE4P Gene

Entrez Gene Summary for ADGRE4P Gene

  • This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008]

GeneCards Summary for ADGRE4P Gene

ADGRE4P (Adhesion G Protein-Coupled Receptor E4, Pseudogene) is a Pseudogene.

UniProtKB/Swiss-Prot for ADGRE4P Gene

  • Could mediated the cellular interaction between myeloid cells and B-cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE4P Gene

Genomics for ADGRE4P Gene

Products:

  1. Regulatory Element

Regulatory Elements for ADGRE4P Gene

Enhancers for ADGRE4P Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRE4P on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRE4P Gene

Chromosome:
19
Start:
6,952,500 bp from pter
End:
6,990,846 bp from pter
Size:
38,347 bases
Orientation:
Minus strand

Genomic View for ADGRE4P Gene

Genes around ADGRE4P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRE4P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRE4P Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGRE4P Gene

Proteins for ADGRE4P Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADGRE4P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SQ3-AGRE4_HUMAN
    Recommended name:
    Putative adhesion G protein-coupled receptor E4P
    Protein Accession:
    Q86SQ3
    Secondary Accessions:
    • Q86SP1

    Protein attributes for ADGRE4P Gene

    Size:
    457 amino acids
    Molecular mass:
    50903 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit).

    Alternative splice isoforms for ADGRE4P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRE4P Gene

Proteomics data for ADGRE4P Gene at MOPED

Post-translational modifications for ADGRE4P Gene

  • Glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn 26, Asn 106, Asn 162, and Asn 245

No data available for DME Specific Peptides for ADGRE4P Gene

Domains & Families for ADGRE4P Gene

Gene Families for ADGRE4P Gene

HGNC:

Protein Domains for ADGRE4P Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRE4P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SQ3

UniProtKB/Swiss-Prot:

AGRE4_HUMAN :
  • Contains 2 EGF-like domains.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 2 EGF-like domains.
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRE4P: view

Function for ADGRE4P Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ADGRE4P Gene

UniProtKB/Swiss-Prot Function:
Could mediated the cellular interaction between myeloid cells and B-cells.

Phenotypes for ADGRE4P Gene

GenomeRNAi human phenotypes for ADGRE4P:
genes like me logo Genes that share phenotypes with ADGRE4P: view

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRE4P Gene

Localization for ADGRE4P Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE4P Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ADGRE4P Gene

Pathways & Interactions for ADGRE4P Gene

SuperPathways for ADGRE4P Gene

PathCards logoMore details on SuperPathways for ADGRE4P
No Data Available

Interacting Proteins for ADGRE4P Gene

Gene Ontology (GO) - Biological Process for ADGRE4P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADGRE4P Gene

Drugs & Compounds for ADGRE4P Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ADGRE4P Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ADGRE4P Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE4P Gene

No ASD Table

Relevant External Links for ADGRE4P Gene

GeneLoc Exon Structure for
ADGRE4P
ECgene alternative splicing isoforms for
ADGRE4P

Expression for ADGRE4P Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ADGRE4P Gene

mRNA expression in normal human tissues for ADGRE4P Gene
mRNA expression by GTEx for ADGRE4P Gene
genes like me logo Genes that share expression patterns with ADGRE4P: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADGRE4P Gene

Orthologs for ADGRE4P Gene

Evolution for ADGRE4P Gene

ENSEMBL:
Gene Tree for ADGRE4P (if available)
TreeFam:
Gene Tree for ADGRE4P (if available)

No data available for Orthologs for ADGRE4P Gene

Paralogs for ADGRE4P Gene

No data available for Paralogs for ADGRE4P Gene

Variants for ADGRE4P Gene

Sequence variations from dbSNP and Humsavar for ADGRE4P Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs795847 -- 6,968,519(+) ttcac(C/T)atgtt intron-variant
rs795848 -- 6,968,532(+) ccagg(A/C/G)tggtc intron-variant
rs795849 -- 6,968,553(+) gacct(A/C/T)gtgat intron-variant
rs795850 -- 6,968,602(+) cgtga(A/G)ccacc intron-variant
rs814279 -- 6,968,313(+) tttta(A/C/T)ttttt intron-variant

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) , Variation tolerance and Relevant External Links for ADGRE4P Gene

Disorders for ADGRE4P Gene

Relevant External Links for ADGRE4P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRE4P

No disorders were found for ADGRE4P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRE4P Gene

Publications for ADGRE4P Gene

  1. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 23 67
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  3. Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence. (PMID: 12731063) Hamann J. … van Lier R.A.W. (Eur. J. Immunol. 2003) 3 23
  4. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. (PMID: 16753812) Caminschi I. … Wright M.D. (DNA Seq. 2006) 3
  5. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PMID: 15203201) Bjarnadottir T.K. … Schioeth H.B. (Genomics 2004) 3

Products for ADGRE4P Gene

Sources for ADGRE4P Gene

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