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Aliases for ADGRE4P Gene

Aliases for ADGRE4P Gene

  • Adhesion G Protein-Coupled Receptor E4, Pseudogene 2 3 5
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 4 Pseudogene 2 3
  • G Protein-Coupled Receptor 127 2 3
  • GPR127 3 4
  • EMR4P 3 4
  • PGR16 3 4
  • EMR4 3 4
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 4 2
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 4 4
  • G-Protein Coupled Receptor PGR16 4
  • G-Protein Coupled Receptor 127 4
  • EGF-Like Module Receptor 4 4
  • EGF-TM7 Receptor EMR4 3
  • FIRE 3

External Ids for ADGRE4P Gene

Previous HGNC Symbols for ADGRE4P Gene

  • GPR127
  • EMR4
  • EMR4P

Summaries for ADGRE4P Gene

Entrez Gene Summary for ADGRE4P Gene

  • This gene is a member of the EGF-TM7 receptor gene family which is thought to play a role in leukocyte adhesion and migration. In other vertebrates, including nonhuman primates, this gene encodes a protein containing N-terminal EGF domains and a C-terminal transmembrane domain. Sequence evidence for the human gene, however, indicates nucleotide deletion in the genomic sequence would result in frameshift and early termination of translation. A protein expressed by this gene would be soluble rather than expressed on the cell surface. As the encoded protein has not been detected, this gene may represent a transcribed pseudogene. [provided by RefSeq, Aug 2008]

GeneCards Summary for ADGRE4P Gene

ADGRE4P (Adhesion G Protein-Coupled Receptor E4, Pseudogene) is a Pseudogene.

UniProtKB/Swiss-Prot for ADGRE4P Gene

  • May mediate the cellular interaction between myeloid cells and B-cells.

Additional gene information for ADGRE4P Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE4P Gene

Genomics for ADGRE4P Gene

Regulatory Elements for ADGRE4P Gene

Enhancers for ADGRE4P Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H006999 0.4 Ensembl 12.9 -2.5 -2518 0.8 GATA3 IKZF1 ADGRE4P PIR44879
GH19H006987 0.7 Ensembl 6.7 +9.8 9786 0.6 PKNOX1 EBF1 BATF ATF7 RUNX3 IKZF2 ZNF687 HLF NR2F1 CEBPB ARHGEF18 ADGRE4P GC19M006963
GH19H006997 0.4 Ensembl 7.3 +0.4 372 0.2 NBN ADGRE4P GC19M006963
GH19H006970 0.7 ENCODE 0.3 +27.4 27370 0.5 L3MBTL2 HCFC1 NFYC MAX USF2 ELF1 ZBTB40 NFYB ZNF143 FOS SLC25A41 GC19M006963 ADGRE4P
GH19H006971 0.2 ENCODE 0.3 +27.7 27708 0.2 GC19M006963 ADGRE4P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRE4P on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRE4P Gene

Genomic Locations for ADGRE4P Gene
chr19:6,952,500-6,997,872
(GRCh38/hg38)
Size:
45,373 bases
Orientation:
Minus strand
chr19:6,952,511-6,990,857
(GRCh37/hg19)

Genomic View for ADGRE4P Gene

Genes around ADGRE4P on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRE4P Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRE4P Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE4P Gene

Proteins for ADGRE4P Gene

  • Protein details for ADGRE4P Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SQ3-AGRE4_HUMAN
    Recommended name:
    Putative adhesion G protein-coupled receptor E4P
    Protein Accession:
    Q86SQ3
    Secondary Accessions:
    • Q86SP1

    Protein attributes for ADGRE4P Gene

    Size:
    457 amino acids
    Molecular mass:
    50903 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit).

    Alternative splice isoforms for ADGRE4P Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRE4P Gene

Post-translational modifications for ADGRE4P Gene

  • Glycosylated.
  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn26, Asn106, Asn162, and Asn245
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRE4P Gene

Domains & Families for ADGRE4P Gene

Gene Families for ADGRE4P Gene

Suggested Antigen Peptide Sequences for ADGRE4P Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SQ3

UniProtKB/Swiss-Prot:

AGRE4_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRE4P: view

Function for ADGRE4P Gene

Molecular function for ADGRE4P Gene

UniProtKB/Swiss-Prot Function:
May mediate the cellular interaction between myeloid cells and B-cells.

Phenotypes From GWAS Catalog for ADGRE4P Gene

Phenotypes for ADGRE4P Gene

GenomeRNAi human phenotypes for ADGRE4P:
genes like me logo Genes that share phenotypes with ADGRE4P: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRE4P Gene

Localization for ADGRE4P Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE4P Gene

Isoform 1: Cell membrane; Multi-pass membrane protein.
Isoform 2: Secreted.

No data available for Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ADGRE4P Gene

Pathways & Interactions for ADGRE4P Gene

SuperPathways for ADGRE4P Gene

No Data Available

Interacting Proteins for ADGRE4P Gene

Selected Interacting proteins: Q86SQ3-AGRE4_HUMAN for ADGRE4P Gene via IID

Symbol External ID(s) Details
YWHAQ

Gene Ontology (GO) - Biological Process for ADGRE4P Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADGRE4P Gene

Drugs & Compounds for ADGRE4P Gene

No Compound Related Data Available

Transcripts for ADGRE4P Gene

mRNA/cDNA for ADGRE4P Gene

(1) REFSEQ mRNAs :
(3) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE4P Gene

No ASD Table

Relevant External Links for ADGRE4P Gene

GeneLoc Exon Structure for
ADGRE4P
ECgene alternative splicing isoforms for
ADGRE4P

Expression for ADGRE4P Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRE4P Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRE4P Gene:

ADGRE4P
genes like me logo Genes that share expression patterns with ADGRE4P: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRE4P Gene

Orthologs for ADGRE4P Gene

Evolution for ADGRE4P Gene

ENSEMBL:
Gene Tree for ADGRE4P (if available)
TreeFam:
Gene Tree for ADGRE4P (if available)

No data available for Orthologs for ADGRE4P Gene

Paralogs for ADGRE4P Gene

No data available for Paralogs for ADGRE4P Gene

Variants for ADGRE4P Gene

Sequence variations from dbSNP and Humsavar for ADGRE4P Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000009379 -- 6,987,993(+) ATAGA(C/G)ACAGA intron-variant
rs1000144961 -- 6,969,470(+) GTAAT(C/T)AGTAC intron-variant
rs1000158600 -- 6,953,222(+) AGAGA(C/T)GAGAT nc-transcript-variant
rs1000172050 -- 6,970,343(+) TATGA(C/G/T)GTATA intron-variant
rs1000174734 -- 6,955,419(+) ATGAA(-/GAT)GATGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRE4P Gene

Variant ID Type Subtype PubMed ID
esv3555956 CNV deletion 23714750
esv33729 CNV gain+loss 17666407
esv2762977 CNV gain+loss 21179565
esv2751811 CNV loss 17911159
esv2751810 CNV loss 17911159
esv2751809 CNV gain 17911159
esv27190 CNV loss 19812545
esv2718080 CNV deletion 23290073
esv2668680 CNV deletion 23128226
esv2662906 CNV deletion 23128226
esv2425378 CNV deletion 19546169
dgv6240n54 CNV loss 21841781
dgv6239n54 CNV loss 21841781
dgv6238n54 CNV loss 21841781
dgv6237n54 CNV gain 21841781
dgv6236n54 CNV gain 21841781
dgv394n27 CNV loss 19166990
dgv393n27 CNV gain 19166990
dgv392n27 CNV gain 19166990
dgv3422n100 CNV loss 25217958
dgv3421n100 CNV gain 25217958
dgv14e196 CNV duplication 17116639
dgv136e55 CNV gain 17911159
nsv956611 CNV deletion 24416366
nsv833729 CNV loss 17160897
nsv578477 CNV loss 21841781
nsv578476 CNV loss 21841781
nsv517794 CNV gain+loss 19592680
nsv1130727 CNV deletion 24896259
nsv1127646 CNV deletion 24896259
nsv1072852 CNV deletion 25765185
nsv1063661 CNV gain 25217958
nsv1061916 CNV gain 25217958
nsv1057286 CNV loss 25217958
nsv1056442 CNV gain 25217958
nsv1056194 CNV gain 25217958
esv3643575 CNV gain 21293372
esv3643574 CNV loss 21293372
esv3643571 CNV gain 21293372
esv3583220 CNV loss 25503493
esv3583219 CNV loss 25503493
esv3574297 CNV gain 25503493

Relevant External Links for ADGRE4P Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRE4P

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ADGRE4P Gene

Disorders for ADGRE4P Gene

Relevant External Links for ADGRE4P

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRE4P

No disorders were found for ADGRE4P Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRE4P Gene

Publications for ADGRE4P Gene

  1. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R … Schiöth HB (Biochemical and biophysical research communications 2003) 2 3 4 22 60
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 60
  3. Inactivation of the EGF-TM7 receptor EMR4 after the Pan-Homo divergence. (PMID: 12731063) Hamann J … van Lier RA (European journal of immunology 2003) 3 4 22 60
  4. Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE. (PMID: 16753812) Caminschi I … Wright MD (DNA sequence : the journal of DNA sequencing and mapping 2006) 3 4 60
  5. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis DK … Gaitanaris GA (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 60

Products for ADGRE4P Gene

Sources for ADGRE4P Gene

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