Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRE3 Gene

Aliases for ADGRE3 Gene

  • Adhesion G Protein-Coupled Receptor E3 2 3
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 3 2 3
  • EGF-Like Module Receptor 3 3 4
  • EMR3 3 4
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 3 3
  • Egf-Like Module-Containing Mucin-Like Receptor 3 3

External Ids for ADGRE3 Gene

Previous Symbols for ADGRE3 Gene

  • EMR3

Summaries for ADGRE3 Gene

Entrez Gene Summary for ADGRE3 Gene

  • This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

GeneCards Summary for ADGRE3 Gene

ADGRE3 (Adhesion G Protein-Coupled Receptor E3) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRE3 Gene

  • Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils

Gene Wiki entry for ADGRE3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE3 Gene

Genomics for ADGRE3 Gene

Genomic Location for ADGRE3 Gene

Start:
14,619,117 bp from pter
End:
14,690,027 bp from pter
Size:
70,911 bases
Orientation:
Minus strand

Genomic View for ADGRE3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE3 Gene

No data available for Regulatory Elements for ADGRE3 Gene

Proteins for ADGRE3 Gene

  • Protein details for ADGRE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BY15-EMR3_HUMAN
    Recommended name:
    EGF-like module-containing mucin-like hormone receptor-like 3
    Protein Accession:
    Q9BY15
    Secondary Accessions:

    Protein attributes for ADGRE3 Gene

    Size:
    652 amino acids
    Molecular mass:
    72621 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit).

    Alternative splice isoforms for ADGRE3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRE3 Gene

Proteomics data for ADGRE3 Gene at MOPED

Post-translational modifications for ADGRE3 Gene

  • Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.

Other Protein References for ADGRE3 Gene

No data available for DME Specific Peptides for ADGRE3 Gene

Domains for ADGRE3 Gene

Gene Families for ADGRE3 Gene

HGNC:
  • GPCRBO :GPCR / Class B : Orphans

UniProtKB/Swiss-Prot:

EMR3_HUMAN
Domain:
  • Contains 2 EGF-like domains.:
    • Q9BY15
  • Contains 1 GPS domain.:
    • Q9BY15
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • Q9BY15
genes like me logo Genes that share domains with ADGRE3: view

Function for ADGRE3 Gene

Molecular function for ADGRE3 Gene

UniProtKB/Swiss-Prot Function: Receptor probably involved in myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of momocytes-derived macrophages and activated neutrophils

Gene Ontology (GO) - Molecular Function for ADGRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ADGRE3: view

Phenotypes for ADGRE3 Gene

GenomeRNAi human phenotypes for ADGRE3:
genes like me logo Genes that share phenotypes with ADGRE3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADGRE3 Gene

Localization for ADGRE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE3 Gene

EGF-like module-containing mucin-like hormone receptor-like 3: Cell membrane; Multi-pass membrane protein.
EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta: Cell membrane; Multi-pass membrane protein.
EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha: Secreted, extracellular space. Note=A soluble form is also detected (alpha subunit).
Isoform 3: Secreted.

Gene Ontology (GO) - Cellular Components for ADGRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IEA --
GO:0005639 integral component of nuclear inner membrane --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ADGRE3: view

Pathways for ADGRE3 Gene

genes like me logo Genes that share pathways with ADGRE3: view

Pathways by source for ADGRE3 Gene

1 BioSystems pathway for ADGRE3 Gene

Interacting Proteins for ADGRE3 Gene

Gene Ontology (GO) - Biological Process for ADGRE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRE3: view

Transcripts for ADGRE3 Gene

mRNA/cDNA for ADGRE3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE3 Gene

No ASD Table

Relevant External Links for ADGRE3 Gene

GeneLoc Exon Structure for
ADGRE3
ECgene alternative splicing isoforms for
ADGRE3

Expression for ADGRE3 Gene

mRNA expression in normal human tissues for ADGRE3 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADGRE3 Gene

mRNA Expression by UniProt/SwissProt for ADGRE3 Gene

Q9BY15-EMR3_HUMAN
Tissue specificity: Displays a predominantly leukocyte-restricted expression, with highest levels in neutrophils, monocytes and macrophages
genes like me logo Genes that share expressions with ADGRE3: view

Orthologs for ADGRE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia EMR3 36
  • 96.48 (n)
  • 94.72 (a)
EMR3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia EMR3 36
  • 81.79 (n)
  • 73.44 (a)
EMR3 37
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMR3 36
  • 80.49 (n)
  • 73.5 (a)
EMR3 37
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emr4 37
  • 39 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 44 (a)
ManyToMany
-- 37
  • 55 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 71 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-341p18.5 37
  • 38 (a)
ManyToMany
si:ch73-341p18.6 37
  • 34 (a)
ManyToMany
si:ch73-341p18.7 37
  • 24 (a)
ManyToMany
si:dkey-29n3.1 37
  • 38 (a)
ManyToMany
si:dkey-9c18.1 37
  • 24 (a)
ManyToMany
si:dkey-9c18.10 37
  • 29 (a)
ManyToMany
si:dkey-9c18.12 37
  • 33 (a)
ManyToMany
si:dkey-9c18.4 37
  • 32 (a)
ManyToMany
si:dkey-9c18.9 37
  • 32 (a)
ManyToMany
Species with no ortholog for ADGRE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRE3 Gene

ENSEMBL:
Gene Tree for ADGRE3 (if available)
TreeFam:
Gene Tree for ADGRE3 (if available)

Paralogs for ADGRE3 Gene

Pseudogenes.org Pseudogenes for ADGRE3 Gene

genes like me logo Genes that share paralogs with ADGRE3: view

Variants for ADGRE3 Gene

Sequence variations from dbSNP and Humsavar for ADGRE3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2482 -- 14,619,297(+) AACAG(C/T)TTGGG utr-variant-3-prime
rs726787 -- 14,632,290(+) CAAAT(A/C/T)TGAGT intron-variant
rs726788 -- 14,632,433(+) GGTCA(A/G)GGTAG intron-variant
rs726789 -- 14,632,191(+) TGATC(C/T)CTATT intron-variant
rs731454 -- 14,629,120(+) GGTTT(C/T)GCCAT intron-variant

Relevant External Links for ADGRE3 Gene

HapMap Linkage Disequilibrium report
ADGRE3

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRE3 Gene

Disorders for ADGRE3 Gene

No disorders were found for ADGRE3 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRE3 Gene

Publications for ADGRE3 Gene

  1. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. (PMID: 11279179) Stacey M. … McKnight A.J. (J. Biol. Chem. 2001) 2 3 4 23
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  5. The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. (PMID: 11994511) Kwakkenbos M.J. … Hamann J. (J. Leukoc. Biol. 2002) 23

Products for ADGRE3 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRE3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRE3
    • Block miRNA regulation of ADGRE3 using miScript Target Protectors
    • antibodies-online proteins for ADGRE3
    • antibodies-online antibodies for ADGRE3
    • antibodies-online kits for ADGRE3

    Sources for ADGRE3 Gene

    Back to Top

    Content