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Aliases for ADGRE2 Gene

Aliases for ADGRE2 Gene

  • Adhesion G Protein-Coupled Receptor E2 2 3 5
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 2 2 3
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 2 3 4
  • EMR2 3 4
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like Sequence 2 2
  • EGF-Like Module Receptor 2 4
  • CD312 Antigen 4
  • CD312 3
  • VBU 3

External Ids for ADGRE2 Gene

Previous HGNC Symbols for ADGRE2 Gene

  • EMR2

Summaries for ADGRE2 Gene

Entrez Gene Summary for ADGRE2 Gene

  • This gene encodes a member of the class B seven-span transmembrane (TM7) subfamily of G-protein coupled receptors. These proteins are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor-like domains coupled to a TM7 domain via a mucin-like spacer domain. The encoded protein is expressed mainly in myeloid cells where it promotes cell-cell adhesion through interaction with chondroitin sulfate chains. This gene is situated in a cluster of related genes on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for ADGRE2 Gene

ADGRE2 (Adhesion G Protein-Coupled Receptor E2) is a Protein Coding gene. Diseases associated with ADGRE2 include Vibratory Urticaria and Physical Urticaria. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRE5.

UniProtKB/Swiss-Prot for ADGRE2 Gene

  • Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.

Gene Wiki entry for ADGRE2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE2 Gene

Genomics for ADGRE2 Gene

Regulatory Elements for ADGRE2 Gene

Enhancers for ADGRE2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ADGRE2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRE2 Gene

Chromosome:
19
Start:
14,724,170 bp from pter
End:
14,778,541 bp from pter
Size:
54,372 bases
Orientation:
Minus strand

Genomic View for ADGRE2 Gene

Genes around ADGRE2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRE2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRE2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE2 Gene

Proteins for ADGRE2 Gene

  • Protein details for ADGRE2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHX3-AGRE2_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor E2
    Protein Accession:
    Q9UHX3
    Secondary Accessions:
    • B4DQ96
    • E7ESD7
    • E9PBR1
    • E9PEL6
    • E9PFQ5
    • E9PG91
    • Q8NG96
    • Q9Y4B1

    Protein attributes for ADGRE2 Gene

    Size:
    823 amino acids
    Molecular mass:
    90472 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55.
    Miscellaneous:
    • Has no murine ortholog.
    SequenceCaution:
    • Sequence=BAC06146.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADGRE2 Gene

    Alternative splice isoforms for ADGRE2 Gene

neXtProt entry for ADGRE2 Gene

Post-translational modifications for ADGRE2 Gene

  • Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit.
  • Glycosylation at Asn 41, Asn 111, Asn 206, Asn 298, Asn 347, Asn 354, Asn 456, and Asn 460
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRE2 Gene

Domains & Families for ADGRE2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHX3

UniProtKB/Swiss-Prot:

AGRE2_HUMAN :
  • The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk.
  • Binding to chondroitin sulfate is mediated by the fourth EGF domain.
  • Contains 5 EGF-like domains.
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRE2: view

Function for ADGRE2 Gene

Molecular function for ADGRE2 Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins.

Gene Ontology (GO) - Molecular Function for ADGRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0035374 chondroitin sulfate binding IMP 12829604
genes like me logo Genes that share ontologies with ADGRE2: view
genes like me logo Genes that share phenotypes with ADGRE2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRE2 Gene

Localization for ADGRE2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE2 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, ruffle membrane; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells. {ECO:0000269 PubMed:17928360}.

Gene Ontology (GO) - Cellular Components for ADGRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0031256 leading edge membrane IDA 17928360
GO:0032587 ruffle membrane IEA --
genes like me logo Genes that share ontologies with ADGRE2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRE2 Gene

Pathways & Interactions for ADGRE2 Gene

genes like me logo Genes that share pathways with ADGRE2: view

Pathways by source for ADGRE2 Gene

Interacting Proteins for ADGRE2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000472280%0d%0a9606.ENSP00000242786%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000080059%0d%0a
Selected Interacting proteins: ENSP00000472280 Q9UHX3-AGRE2_HUMAN for ADGRE2 Gene via STRING IID

Gene Ontology (GO) - Biological Process for ADGRE2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006954 inflammatory response IEA --
GO:0007155 cell adhesion IMP 12829604
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0016477 cell migration IMP 17928360
genes like me logo Genes that share ontologies with ADGRE2: view

No data available for SIGNOR curated interactions for ADGRE2 Gene

Drugs & Compounds for ADGRE2 Gene

(1) Drugs for ADGRE2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ADGRE2: view

Transcripts for ADGRE2 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1: - -
SP2: - -
SP3: - - - -
SP4: - - - -
SP5:

Relevant External Links for ADGRE2 Gene

GeneLoc Exon Structure for
ADGRE2
ECgene alternative splicing isoforms for
ADGRE2

Expression for ADGRE2 Gene

mRNA expression in normal human tissues for ADGRE2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRE2 Gene

This gene is overexpressed in Monocytes (27.4), Spleen (24.7), and Liver (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRE2 Gene



Protein tissue co-expression partners for ADGRE2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRE2 Gene:

ADGRE2

mRNA Expression by UniProt/SwissProt for ADGRE2 Gene:

Q9UHX3-AGRE2_HUMAN
Tissue specificity: Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested.
genes like me logo Genes that share expression patterns with ADGRE2: view

Primer Products

No data available for mRNA differential expression in normal tissues for ADGRE2 Gene

Orthologs for ADGRE2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRE2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia EMR2 34
  • 81.44 (n)
  • 71.98 (a)
-- 35
  • 61 (a)
OneToMany
-- 35
  • 64 (a)
OneToMany
EMR2 35
  • 69 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia EMR2 34
  • 96.36 (n)
  • 95.18 (a)
EMR2 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 35
  • 77 (a)
OneToMany
-- 35
  • 67 (a)
OneToMany
-- 35
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 41 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 35 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-9c18.6 35
  • 28 (a)
ManyToMany
Species where no ortholog for ADGRE2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRE2 Gene

ENSEMBL:
Gene Tree for ADGRE2 (if available)
TreeFam:
Gene Tree for ADGRE2 (if available)

Paralogs for ADGRE2 Gene

Pseudogenes.org Pseudogenes for ADGRE2 Gene

genes like me logo Genes that share paralogs with ADGRE2: view

Variants for ADGRE2 Gene

Sequence variations from dbSNP and Humsavar for ADGRE2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs4410209 - 14,751,646(+) GCAAG(A/G)TACCG nc-transcript-variant, reference, missense
rs2524383 - 14,751,618(+) CAGGT(C/G)AAGGT nc-transcript-variant, reference, missense
rs3752187 - 14,751,466(+) GCCTG(A/G)AGGCT nc-transcript-variant, downstream-variant-500B, reference, missense
rs35612307 - 14,764,576(+) CAGGG(A/G)CCTCC nc-transcript-variant, reference, missense
rs57865820 - 14,746,255(+) GACAC(G/T)TCACT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADGRE2 Gene

Variant ID Type Subtype PubMed ID
esv1001961 CNV insertion 20482838
esv2656782 CNV deletion 23128226
esv3342641 CNV duplication 20981092
esv3643750 CNV loss 21293372
esv3893167 CNV gain 25118596
nsv458357 CNV loss 19166990
nsv509722 CNV insertion 20534489
nsv578680 CNV loss 21841781
nsv953982 CNV deletion 24416366
nsv954652 CNV deletion 24416366
nsv961186 CNV duplication 23825009

Variation tolerance for ADGRE2 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.98; 79.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRE2 Gene

Human Gene Mutation Database (HGMD)
ADGRE2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRE2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRE2 Gene

Disorders for ADGRE2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADGRE2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
vibratory urticaria
  • angioedema, vibratory
physical urticaria
  • symptomatic dermographism
vertebrobasilar insufficiency
  • vertebro-basilar insufficiency
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADGRE2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRE2
genes like me logo Genes that share disorders with ADGRE2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRE2 Gene

Publications for ADGRE2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 65
  2. Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. (PMID: 17928360) Yona S. … Stacey M. (FASEB J. 2008) 3 4 22 65
  3. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. (PMID: 12829604) Stacey M. … Lin H.-H. (Blood 2003) 3 4 22 65
  4. The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. (PMID: 11994511) Kwakkenbos M.J. … Hamann J. (J. Leukoc. Biol. 2002) 3 4 22 65
  5. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. (PMID: 10903844) Lin H.-H. … McKnight A.J. (Genomics 2000) 3 4 22 65

Products for ADGRE2 Gene

Sources for ADGRE2 Gene

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