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Aliases for ADGRE1 Gene

Aliases for ADGRE1 Gene

  • Adhesion G Protein-Coupled Receptor E1 2 3 5
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like Sequence 1 2 3
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 1 2 3
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 1 3 4
  • EGF-Like Module Receptor 1 3 4
  • EMR1 Hormone Receptor 3 4
  • TM7LN3 3 4
  • EMR1 3 4

External Ids for ADGRE1 Gene

Previous HGNC Symbols for ADGRE1 Gene

  • TM7LN3
  • EMR1

Summaries for ADGRE1 Gene

Entrez Gene Summary for ADGRE1 Gene

  • This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ADGRE1 Gene

ADGRE1 (Adhesion G Protein-Coupled Receptor E1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRE1 Gene

  • Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Gene Wiki entry for ADGRE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE1 Gene

Genomics for ADGRE1 Gene

Regulatory Elements for ADGRE1 Gene

Promoters for ADGRE1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADGRE1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRE1 Gene

Chromosome:
19
Start:
6,887,549 bp from pter
End:
6,940,459 bp from pter
Size:
52,911 bases
Orientation:
Plus strand

Genomic View for ADGRE1 Gene

Genes around ADGRE1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRE1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE1 Gene

Proteins for ADGRE1 Gene

  • Protein details for ADGRE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14246-AGRE1_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor E1
    Protein Accession:
    Q14246
    Secondary Accessions:
    • A6NHV2
    • B7Z486
    • B7Z489
    • E7EPX9
    • E9PD45
    • H9KV79
    • Q2I7G5
    • Q6ZMN0
    • Q8NGA7

    Protein attributes for ADGRE1 Gene

    Size:
    886 amino acids
    Molecular mass:
    97683 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRE1 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.
    SequenceCaution:
    • Sequence=BAC06133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRE1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRE1 Gene

Proteomics data for ADGRE1 Gene at MOPED

Post-translational modifications for ADGRE1 Gene

  • Glycosylation at Asn 94, Asn 99, Asn 127, Asn 167, Asn 189, Asn 194, Asn 232, Asn 258, Asn 312, Asn 366, Asn 375, and Asn 448
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRE1 Gene

Domains & Families for ADGRE1 Gene

Gene Families for ADGRE1 Gene

Suggested Antigen Peptide Sequences for ADGRE1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14246

UniProtKB/Swiss-Prot:

AGRE1_HUMAN :
  • Contains 6 EGF-like domains.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 6 EGF-like domains.
  • Contains 1 GPS domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRE1: view

Function for ADGRE1 Gene

Molecular function for ADGRE1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Gene Ontology (GO) - Molecular Function for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ADGRE1: view
genes like me logo Genes that share phenotypes with ADGRE1: view

Animal Models for ADGRE1 Gene

MGI Knock Outs for ADGRE1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRE1

miRNA for ADGRE1 Gene

miRTarBase miRNAs that target ADGRE1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRE1 Gene

Localization for ADGRE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRE1: view

No data available for Subcellular locations from COMPARTMENTS for ADGRE1 Gene

Pathways & Interactions for ADGRE1 Gene

genes like me logo Genes that share pathways with ADGRE1: view

Interacting Proteins for ADGRE1 Gene

Gene Ontology (GO) - Biological Process for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
genes like me logo Genes that share ontologies with ADGRE1: view

No data available for SIGNOR curated interactions for ADGRE1 Gene

Drugs & Compounds for ADGRE1 Gene

No Compound Related Data Available

Transcripts for ADGRE1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - -
SP2: - - - -
SP3: - - -
SP4:

Relevant External Links for ADGRE1 Gene

GeneLoc Exon Structure for
ADGRE1
ECgene alternative splicing isoforms for
ADGRE1

Expression for ADGRE1 Gene

mRNA expression in normal human tissues for ADGRE1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA Expression by UniProt/SwissProt for ADGRE1 Gene

Q14246-AGRE1_HUMAN
Tissue specificity: Expression is restricted to eosinophils.
genes like me logo Genes that share expression patterns with ADGRE1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ADGRE1 Gene

Orthologs for ADGRE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRE1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EMR1 35
  • 80.17 (n)
  • 73.7 (a)
EMR1 36
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EMR1 35
  • 75.36 (n)
  • 68.12 (a)
EMR1 36
  • 55 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Emr1 35
  • 71.89 (n)
  • 65.32 (a)
Adgre1 16
Emr1 36
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EMR1 35
  • 98.8 (n)
  • 97.63 (a)
EMR1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Emr1 35
  • 71.15 (n)
  • 63.98 (a)
oppossum
(Monodelphis domestica)
Mammalia EMR1 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EMR1 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730714 35
  • 63.2 (n)
  • 58.96 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18311 35
zebrafish
(Danio rerio)
Actinopterygii si:ch73-268p17.1 36
  • 28 (a)
ManyToMany
Species with no ortholog for ADGRE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRE1 Gene

ENSEMBL:
Gene Tree for ADGRE1 (if available)
TreeFam:
Gene Tree for ADGRE1 (if available)

Paralogs for ADGRE1 Gene

Pseudogenes.org Pseudogenes for ADGRE1 Gene

genes like me logo Genes that share paralogs with ADGRE1: view

Variants for ADGRE1 Gene

Sequence variations from dbSNP and Humsavar for ADGRE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs330877 - 6,896,472(+) ATTGC(A/G/T)CTTGC reference, missense
rs330880 - 6,897,453(+) AGCAG(C/G/T)GTCTG intron-variant, reference, missense, splice-donor-variant
VAR_027618 -
VAR_027619 -
VAR_027620 -

Variation tolerance for ADGRE1 Gene

Residual Variation Intolerance Score: 98.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.18; 92.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRE1 Gene

HapMap Linkage Disequilibrium report
ADGRE1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRE1 Gene

Disorders for ADGRE1 Gene

Relevant External Links for ADGRE1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRE1

No disorders were found for ADGRE1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRE1 Gene

Publications for ADGRE1 Gene

  1. EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. (PMID: 7601460) Baud V. … Lipinski M. (Genomics 1995) 2 3 4 23 67
  2. The EGF-TM7 family: unusual structures at the leukocyte surface. (PMID: 9500513) McKnight A.J. … Gordon S. (J. Leukoc. Biol. 1998) 2 3 23
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  4. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. (PMID: 17823986) Hamann J. … Kwakkenbos M.J. (Eur. J. Immunol. 2007) 3 23
  5. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. (PMID: 10903844) Lin H.-H. … McKnight A.J. (Genomics 2000) 3 23

Products for ADGRE1 Gene

Sources for ADGRE1 Gene

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