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Aliases for ADGRE1 Gene

Aliases for ADGRE1 Gene

  • Adhesion G Protein-Coupled Receptor E1 2 3
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like Sequence 1 2 3
  • Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 1 2 3
  • EGF-Like Module Receptor 1 3 4
  • EMR1 Hormone Receptor 3 4
  • TM7LN3 3 4
  • EMR1 3 6
  • EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 1 3

External Ids for ADGRE1 Gene

Previous Symbols for ADGRE1 Gene

  • TM7LN3
  • EMR1

Summaries for ADGRE1 Gene

Entrez Gene Summary for ADGRE1 Gene

  • This gene encodes a protein that has a domain resembling seven transmembrane G protein-coupled hormone receptors (7TM receptors) at its C-terminus. The N-terminus of the encoded protein has six EGF-like modules, separated from the transmembrane segments by a serine/threonine-rich domain, a feature reminiscent of mucin-like, single-span, integral membrane glycoproteins with adhesive properties. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ADGRE1 Gene

ADGRE1 (Adhesion G Protein-Coupled Receptor E1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRE1 Gene

  • Could be involved in cell-cell interactions

Gene Wiki entry for ADGRE1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRE1 Gene

Genomics for ADGRE1 Gene

Genomic Location for ADGRE1 Gene

6,887,549 bp from pter
6,940,459 bp from pter
52,911 bases
Plus strand

Genomic View for ADGRE1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRE1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRE1 Gene

No data available for Regulatory Elements for ADGRE1 Gene

Proteins for ADGRE1 Gene

  • Protein details for ADGRE1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    EGF-like module-containing mucin-like hormone receptor-like 1
    Protein Accession:
    Secondary Accessions:
    • A6NHV2
    • B7Z486
    • B7Z489
    • E7EPX9
    • E9PD45
    • H9KV79
    • Q2I7G5
    • Q6ZMN0
    • Q8NGA7

    Protein attributes for ADGRE1 Gene

    886 amino acids
    Molecular mass:
    97683 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC06133.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRE1 Gene


neXtProt entry for ADGRE1 Gene

Proteomics data for ADGRE1 Gene at MOPED

Post-translational modifications for ADGRE1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRE1 Gene

No data available for DME Specific Peptides for ADGRE1 Gene

Domains for ADGRE1 Gene

Gene Families for ADGRE1 Gene

  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry



  • Contains 6 EGF-like domains.:
    • Q14246
  • Contains 1 GPS domain.:
    • Q14246
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • Q14246
genes like me logo Genes that share domains with ADGRE1: view

No data available for Suggested Antigen Peptide Sequences for ADGRE1 Gene

Function for ADGRE1 Gene

Molecular function for ADGRE1 Gene

UniProtKB/Swiss-Prot Function: Could be involved in cell-cell interactions

Gene Ontology (GO) - Molecular Function for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ADGRE1: view

Phenotypes for ADGRE1 Gene

genes like me logo Genes that share phenotypes with ADGRE1: view

Animal Models for ADGRE1 Gene

MGI Knock Outs for ADGRE1:

miRNA for ADGRE1 Gene

miRTarBase miRNAs that target ADGRE1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADGRE1 Gene

Localization for ADGRE1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRE1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane --
GO:0005887 integral component of plasma membrane TAS 7601460
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with ADGRE1: view

No data available for Subcellular locations from COMPARTMENTS for ADGRE1 Gene

Pathways for ADGRE1 Gene

genes like me logo Genes that share pathways with ADGRE1: view

Pathways by source for ADGRE1 Gene

Interacting Proteins for ADGRE1 Gene

Gene Ontology (GO) - Biological Process for ADGRE1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion TAS 7601460
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRE1: view

Transcripts for ADGRE1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRE1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21
SP1: - - -
SP2: - - - -
SP3: - - -

Relevant External Links for ADGRE1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRE1 Gene

mRNA expression in normal human tissues for ADGRE1 Gene

mRNA Expression by UniProt/SwissProt for ADGRE1 Gene

Tissue specificity: Wide expression; increased levels in peripheral blood mononuclear cells
genes like me logo Genes that share expressions with ADGRE1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for ADGRE1 Gene

Orthologs for ADGRE1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGRE1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia EMR1 35
  • 98.8 (n)
  • 97.63 (a)
EMR1 36
  • 98 (a)
(Bos Taurus)
Mammalia EMR1 35
  • 80.17 (n)
  • 73.7 (a)
EMR1 36
  • 55 (a)
(Canis familiaris)
Mammalia EMR1 35
  • 75.36 (n)
  • 68.12 (a)
EMR1 36
  • 55 (a)
(Mus musculus)
Mammalia Emr1 35
  • 71.89 (n)
  • 65.32 (a)
Emr1 16
Emr1 36
  • 65 (a)
(Monodelphis domestica)
Mammalia EMR1 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia EMR1 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Emr1 35
  • 71.15 (n)
  • 63.98 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.18311 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730714 35
  • 63.2 (n)
  • 58.96 (a)
(Danio rerio)
Actinopterygii si:ch73-268p17.1 36
  • 28 (a)
Species with no ortholog for ADGRE1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRE1 Gene

Gene Tree for ADGRE1 (if available)
Gene Tree for ADGRE1 (if available)

Paralogs for ADGRE1 Gene Pseudogenes for ADGRE1 Gene

genes like me logo Genes that share paralogs with ADGRE1: view

Variants for ADGRE1 Gene

Sequence variations from dbSNP and Humsavar for ADGRE1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs162585 -- 6,893,735(-) aaTGG(A/G)CACCa intron-variant
rs168780 -- 6,936,309(+) tgggc(A/G)cctgt intron-variant
rs168781 -- 6,925,702(-) aaaat(A/T)aaaaa intron-variant
rs171674 -- 6,919,518(-) AAGGA(A/G)GGAAT intron-variant
rs252548 -- 6,934,668(+) tctca(A/G)ctgtc intron-variant

Relevant External Links for ADGRE1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRE1 Gene

Disorders for ADGRE1 Gene

No disorders were found for ADGRE1 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRE1 Gene

Publications for ADGRE1 Gene

  1. EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments. (PMID: 7601460) Baud V. … Lipinski M. (Genomics 1995) 2 3 4 23
  2. The EGF-TM7 family: unusual structures at the leukocyte surface. (PMID: 9500513) McKnight A.J. … Gordon S. (J. Leukoc. Biol. 1998) 2 3 23
  3. Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. (PMID: 10903844) Lin H.-H. … McKnight A.J. (Genomics 2000) 3 23
  4. EMR1, the human homolog of F4/80, is an eosinophil-specific receptor. (PMID: 17823986) Hamann J. … Kwakkenbos M.J. (Eur. J. Immunol. 2007) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ADGRE1 Gene

Sources for ADGRE1 Gene

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