Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADGRD2 Gene

Aliases for ADGRD2 Gene

  • Adhesion G Protein-Coupled Receptor D2 2 3 5
  • G-Protein Coupled Receptor PGR24 3 4
  • G Protein-Coupled Receptor 144 2 3
  • G-Protein Coupled Receptor 144 3 4
  • GPR144 3 4
  • PGR24 3 4
  • G-Protein Coupled Receptor GPR144 3
  • G Protein-Coupled Receptor PGR24 3

External Ids for ADGRD2 Gene

Previous HGNC Symbols for ADGRD2 Gene

  • GPR144

Summaries for ADGRD2 Gene

GeneCards Summary for ADGRD2 Gene

ADGRD2 (Adhesion G Protein-Coupled Receptor D2) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRD2 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRD2 Gene

Genomics for ADGRD2 Gene

Regulatory Elements for ADGRD2 Gene

Enhancers for ADGRD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRD2 Gene

124,451,087 bp from pter
124,478,589 bp from pter
27,503 bases
Plus strand

Genomic View for ADGRD2 Gene

Genes around ADGRD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRD2 Gene

Proteins for ADGRD2 Gene

  • Protein details for ADGRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor D2
    Protein Accession:
    Secondary Accessions:
    • Q86SL4
    • Q8NH12

    Protein attributes for ADGRD2 Gene

    963 amino acids
    Molecular mass:
    104087 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ADGRD2 Gene

Proteomics data for ADGRD2 Gene at MOPED

Post-translational modifications for ADGRD2 Gene

  • Glycosylation at Asn 271 and Asn 634
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRD2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ADGRD2 Gene

Domains & Families for ADGRD2 Gene

Gene Families for ADGRD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Contains 1 GPS domain.
  • Contains 1 pentaxin domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRD2: view

Function for ADGRD2 Gene

Molecular function for ADGRD2 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.
genes like me logo Genes that share phenotypes with ADGRD2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRD2 Gene

Localization for ADGRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRD2 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRD2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRD2 Gene

Pathways & Interactions for ADGRD2 Gene

SuperPathways for ADGRD2 Gene

No Data Available

Interacting Proteins for ADGRD2 Gene

Gene Ontology (GO) - Biological Process for ADGRD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ADGRD2 Gene

Drugs & Compounds for ADGRD2 Gene

No Compound Related Data Available

Transcripts for ADGRD2 Gene

mRNA/cDNA for ADGRD2 Gene

(4) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRD2 Gene

No ASD Table

Relevant External Links for ADGRD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRD2 Gene

mRNA expression in normal human tissues for ADGRD2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRD2 Gene

genes like me logo Genes that share expression patterns with ADGRD2: view

Protein tissue co-expression partners for ADGRD2 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRD2 Gene

Orthologs for ADGRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR144 35
  • 84.87 (n)
  • 80.82 (a)
GPR144 36
  • 71 (a)
(Canis familiaris)
Mammalia GPR144 35
  • 82.67 (n)
  • 79.25 (a)
GPR144 36
  • 64 (a)
(Pan troglodytes)
Mammalia GPR144 35
  • 98.68 (n)
  • 97.61 (a)
GPR144 36
  • 98 (a)
(Monodelphis domestica)
Mammalia GPR144 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia GPR144 36
  • 52 (a)
(Gallus gallus)
Aves GPR144 35
  • 56.67 (n)
  • 47.75 (a)
GPR144 36
  • 38 (a)
(Anolis carolinensis)
Reptilia GPR144 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr144 35
  • 52.59 (n)
  • 44.16 (a)
(Danio rerio)
Actinopterygii gpr144 35
  • 51.29 (n)
  • 39.56 (a)
gpr144 36
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lat-2 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
Species with no ortholog for ADGRD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRD2 Gene

Gene Tree for ADGRD2 (if available)
Gene Tree for ADGRD2 (if available)

Paralogs for ADGRD2 Gene

genes like me logo Genes that share paralogs with ADGRD2: view

Variants for ADGRD2 Gene

Sequence variations from dbSNP and Humsavar for ADGRD2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7850687 -- 124,468,031(+) CCCTA(C/T)GGGGT intron-variant
rs7850739 -- 124,458,969(+) AAAGC(A/T)TGGGA intron-variant
rs7851429 -- 124,462,493(+) actgt(A/G)tatat intron-variant
rs7851555 -- 124,462,586(+) gtgat(A/G)tatac intron-variant
rs7852358 -- 124,456,023(+) catgg(A/G)tagtg intron-variant

Variation tolerance for ADGRD2 Gene

Gene Damage Index Score: 9.71; 89.30% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRD2 Gene

Disorders for ADGRD2 Gene

Relevant External Links for ADGRD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADGRD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRD2 Gene

Publications for ADGRD2 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. The Secretin GPCRs descended from the family of Adhesion GPCRs. (PMID: 18845549) NordstrAPm K.J. … SchiAPth H.B. (Mol. Biol. Evol. 2009) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3

Products for ADGRD2 Gene

Sources for ADGRD2 Gene