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Aliases for ADGRD2 Gene

Aliases for ADGRD2 Gene

  • Adhesion G Protein-Coupled Receptor D2 2 3
  • G-Protein Coupled Receptor PGR24 3 4
  • G Protein-Coupled Receptor 144 2 3
  • GPR144 3 4
  • PGR24 3 4
  • G-Protein Coupled Receptor GPR144 3
  • G Protein-Coupled Receptor PGR24 3

External Ids for ADGRD2 Gene

Previous HGNC Symbols for ADGRD2 Gene

  • GPR144

Summaries for ADGRD2 Gene

GeneCards Summary for ADGRD2 Gene

ADGRD2 (Adhesion G Protein-Coupled Receptor D2) is a Protein Coding gene. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRD2 Gene

  • Orphan receptor

Gene Wiki entry for ADGRD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRD2 Gene

Genomics for ADGRD2 Gene

Genomic Location for ADGRD2 Gene

124,451,144 bp from pter
124,478,589 bp from pter
27,446 bases
Plus strand

Genomic View for ADGRD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRD2 Gene

No data available for Regulatory Elements for ADGRD2 Gene

Proteins for ADGRD2 Gene

  • Protein details for ADGRD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 144
    Protein Accession:
    Secondary Accessions:
    • Q86SL4
    • Q8NH12

    Protein attributes for ADGRD2 Gene

    963 amino acids
    Molecular mass:
    104087 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC05829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for ADGRD2 Gene

Proteomics data for ADGRD2 Gene at MOPED

Post-translational modifications for ADGRD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRD2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for ADGRD2 Gene

Domains for ADGRD2 Gene

Gene Families for ADGRD2 Gene

  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry



  • Q7Z7M1
  • Contains 1 GPS domain.
  • Contains 1 pentaxin domain.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRD2: view

No data available for Suggested Antigen Peptide Sequences for ADGRD2 Gene

Function for ADGRD2 Gene

Molecular function for ADGRD2 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor

Gene Ontology (GO) - Molecular Function for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRD2: view

Phenotypes for ADGRD2 Gene

GenomeRNAi human phenotypes for ADGRD2:
genes like me logo Genes that share phenotypes with ADGRD2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADGRD2 Gene

Localization for ADGRD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRD2 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRD2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRD2 Gene

Pathways for ADGRD2 Gene

SuperPathways for ADGRD2 Gene

No Data Available

Interacting Proteins for ADGRD2 Gene

Gene Ontology (GO) - Biological Process for ADGRD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRD2: view

No data available for Pathways by source for ADGRD2 Gene

Transcripts for ADGRD2 Gene

mRNA/cDNA for ADGRD2 Gene

(4) REFSEQ mRNAs :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRD2 Gene

No ASD Table

Relevant External Links for ADGRD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRD2 Gene

mRNA expression in normal human tissues for ADGRD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADGRD2 Gene

genes like me logo Genes that share expressions with ADGRD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRD2 Gene

Orthologs for ADGRD2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR144 35
  • 98.68 (n)
  • 97.61 (a)
GPR144 36
  • 98 (a)
(Bos Taurus)
Mammalia GPR144 35
  • 84.87 (n)
  • 80.82 (a)
GPR144 36
  • 71 (a)
(Canis familiaris)
Mammalia GPR144 35
  • 82.67 (n)
  • 79.25 (a)
GPR144 36
  • 64 (a)
(Monodelphis domestica)
Mammalia GPR144 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia GPR144 36
  • 52 (a)
(Gallus gallus)
Aves GPR144 35
  • 56.67 (n)
  • 47.75 (a)
GPR144 36
  • 38 (a)
(Anolis carolinensis)
Reptilia GPR144 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr144 35
  • 52.59 (n)
  • 44.16 (a)
(Danio rerio)
Actinopterygii gpr144 35
  • 51.29 (n)
  • 39.56 (a)
gpr144 36
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lat-2 36
  • 10 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 13 (a)
Species with no ortholog for ADGRD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRD2 Gene

Gene Tree for ADGRD2 (if available)
Gene Tree for ADGRD2 (if available)

Paralogs for ADGRD2 Gene

genes like me logo Genes that share paralogs with ADGRD2: view

Variants for ADGRD2 Gene

Sequence variations from dbSNP and Humsavar for ADGRD2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1006009 -- 124,450,138(-) AGGCC(C/T)CTCGG upstream-variant-2KB
rs1570578 -- 124,465,894(+) CAAAT(G/T)GGCGT intron-variant
rs1570579 -- 124,465,929(+) GGCCC(G/T)TGGAC intron-variant
rs1570580 -- 124,469,495(+) GTGCC(A/C/G)GCATG missense, reference
rs1570581 -- 124,471,780(+) gtgcc(A/G)ggccg intron-variant

Relevant External Links for ADGRD2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRD2 Gene

Disorders for ADGRD2 Gene

No disorders were found for ADGRD2 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRD2 Gene

Publications for ADGRD2 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 3 4
  2. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PMID: 15203201) Bjarnadottir T.K. … Schioeth H.B. (Genomics 2004) 3 4
  3. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  4. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ADGRD2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRD2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRD2
    • Block miRNA regulation of ADGRD2 using miScript Target Protectors
    • antibodies-online peptides for ADGRD2
    • antibodies-online antibodies for ADGRD2
    • antibodies-online kits for ADGRD2

    Sources for ADGRD2 Gene

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