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Aliases for ADGRD1 Gene

Aliases for ADGRD1 Gene

  • Adhesion G Protein-Coupled Receptor D1 2 3
  • GPR133 3 4 6
  • PGR25 3 4 6
  • G-Protein Coupled Receptor PGR25 3 4
  • G Protein-Coupled Receptor 133 2 3
  • Probable G-Protein Coupled Receptor 133 3

External Ids for ADGRD1 Gene

Previous HGNC Symbols for ADGRD1 Gene

  • GPR133

Summaries for ADGRD1 Gene

Entrez Gene Summary for ADGRD1 Gene

  • The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

GeneCards Summary for ADGRD1 Gene

ADGRD1 (Adhesion G Protein-Coupled Receptor D1) is a Protein Coding gene. Among its related pathways are GPCRs, Other. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRD1 Gene

  • Orphan receptor

Gene Wiki entry for ADGRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRD1 Gene

Genomics for ADGRD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADGRD1 Gene

130,953,907 bp from pter
131,141,469 bp from pter
187,563 bases
Plus strand

Genomic View for ADGRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRD1 Gene

No data available for Regulatory Elements for ADGRD1 Gene

Proteins for ADGRD1 Gene

  • Protein details for ADGRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable G-protein coupled receptor 133
    Protein Accession:
    Secondary Accessions:
    • B2CKK9
    • B7ZLF7
    • Q2M1L3
    • Q6ZMQ1
    • Q7Z7M2
    • Q86SM4

    Protein attributes for ADGRD1 Gene

    874 amino acids
    Molecular mass:
    96530 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADGRD1 Gene


neXtProt entry for ADGRD1 Gene

Proteomics data for ADGRD1 Gene at MOPED

Post-translational modifications for ADGRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRD1 Gene

No data available for DME Specific Peptides for ADGRD1 Gene

Domains for ADGRD1 Gene

Gene Families for ADGRD1 Gene

  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry



  • Q6QNK2
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRD1: view

No data available for Suggested Antigen Peptide Sequences for ADGRD1 Gene

Function for ADGRD1 Gene

Molecular function for ADGRD1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor

Gene Ontology (GO) - Molecular Function for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRD1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADGRD1 Gene

Localization for ADGRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRD1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRD1: view

No data available for Subcellular locations from COMPARTMENTS for ADGRD1 Gene

Pathways for ADGRD1 Gene

SuperPathways for ADGRD1 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with ADGRD1: view

Pathways by source for ADGRD1 Gene

1 BioSystems pathway for ADGRD1 Gene

Interacting Proteins for ADGRD1 Gene

Gene Ontology (GO) - Biological Process for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRD1: view

Transcripts for ADGRD1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRD1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRD1 Gene

No ASD Table

Relevant External Links for ADGRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRD1 Gene

mRNA expression in normal human tissues for ADGRD1 Gene

Protein differential expression in normal tissues for ADGRD1 Gene

This gene is overexpressed in Liver (38.6), Heart (12.9), and Kidney (8.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADGRD1 Gene

genes like me logo Genes that share expressions with ADGRD1: view

Expression partners for ADGRD1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRD1 Gene

Orthologs for ADGRD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR133 35
  • 84.02 (n)
  • 82.07 (a)
GPR133 36
  • 79 (a)
(Canis familiaris)
Mammalia GPR133 35
  • 81.67 (n)
  • 78.59 (a)
GPR133 36
  • 78 (a)
(Mus musculus)
Mammalia Gpr133 35
  • 78.95 (n)
  • 80.83 (a)
Gpr133 16
Gpr133 36
  • 78 (a)
(Pan troglodytes)
Mammalia GPR133 35
  • 99.13 (n)
  • 98.96 (a)
(Rattus norvegicus)
Mammalia Gpr133 35
  • 79.27 (n)
  • 79.77 (a)
(Monodelphis domestica)
Mammalia GPR133 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia GPR133 36
  • 77 (a)
(Gallus gallus)
Aves GPR133 35
  • 68.38 (n)
  • 69.3 (a)
GPR133 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 6 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr133 35
  • 63.43 (n)
  • 61.66 (a)
(Danio rerio)
Actinopterygii gpr133 35
  • 62 (n)
  • 58.36 (a)
BX649292.1 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lat-2 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
Species with no ortholog for ADGRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRD1 Gene

Gene Tree for ADGRD1 (if available)
Gene Tree for ADGRD1 (if available)

Paralogs for ADGRD1 Gene Pseudogenes for ADGRD1 Gene

genes like me logo Genes that share paralogs with ADGRD1: view

Variants for ADGRD1 Gene

Sequence variations from dbSNP and Humsavar for ADGRD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2926 -- 130,986,525(-) ACTAA(C/T)GAGTG intron-variant
rs819113 -- 131,050,023(+) CCCTC(C/T)ACCTG intron-variant
rs819114 -- 130,967,007(+) TGTGC(A/C)TTTTC intron-variant, upstream-variant-2KB
rs819115 -- 131,088,771(-) GTCAT(A/C)TGCAG intron-variant
rs819116 -- 130,956,884(+) atgca(C/T)acaca intron-variant

Relevant External Links for ADGRD1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRD1 Gene

Disorders for ADGRD1 Gene

No disorders were found for ADGRD1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ADGRD1 Gene

Publications for ADGRD1 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PMID: 15203201) Bjarnadottir T.K. … Schioeth H.B. (Genomics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3

Products for ADGRD1 Gene

Sources for ADGRD1 Gene

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