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Aliases for ADGRD1 Gene

Aliases for ADGRD1 Gene

  • Adhesion G Protein-Coupled Receptor D1 2 3 5
  • G-Protein Coupled Receptor PGR25 3 4
  • G-Protein Coupled Receptor 133 3 4
  • GPR133 3 4
  • PGR25 3 4
  • Probable G-Protein Coupled Receptor 133 3
  • Adhesion G-Protein Coupled Receptor D1 3
  • G Protein-Coupled Receptor 133 2

External Ids for ADGRD1 Gene

Previous HGNC Symbols for ADGRD1 Gene

  • GPR133

Summaries for ADGRD1 Gene

Entrez Gene Summary for ADGRD1 Gene

  • The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

GeneCards Summary for ADGRD1 Gene

ADGRD1 (Adhesion G Protein-Coupled Receptor D1) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRL1.

UniProtKB/Swiss-Prot for ADGRD1 Gene

  • Orphan receptor. Signals via G(s)-alpha family of G-proteins.

Gene Wiki entry for ADGRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRD1 Gene

Genomics for ADGRD1 Gene

Regulatory Elements for ADGRD1 Gene

Enhancers for ADGRD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F131027 1.1 FANTOM5 Ensembl ENCODE 15.9 +74.8 74833 1.6 ZNF687 CUX1 FOS ZIC2 ADGRD1 ENSG00000256151 ENSG00000279993 ENSG00000256810
GH12F131782 1.2 Ensembl ENCODE 12 +830.7 830727 4.0 TBP HDAC1 ATF1 CBX3 PKNOX1 TBL1XR1 CREB3L1 INSM2 SIN3A ZBTB40 MMP17 SFSWAP EP400 EP400NL RNU6-1017P ADGRD1 DDX51 NOC4L RNA5SP378 GC12M131802
GH12F130978 1.2 Ensembl ENCODE 11.3 +28.2 28173 6.6 HDGF PKNOX1 ATF1 ARID4B FEZF1 TBX21 PPARG MEF2D RCOR2 NBN ADGRD1 ENSG00000256151 ENSG00000256204 ENSG00000279581 ENSG00000280002
GH12F131709 1.1 ENCODE 12 +757.5 757474 2.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 EP400 ADGRD1 NOC4L SFSWAP DDX51 ENSG00000255933
GH12F130986 0.8 ENCODE 16.4 +34.2 34217 3.6 SOX13 BCOR DRAP1 TFAP4 SAP130 ZMYM3 ZIC2 POLR2A SCRT2 ADNP ADGRD1 ENSG00000256151 ENSG00000280002 ENSG00000279581
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRD1 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001782467 793 2201 BRD4 CTCF CBX3 ZIC2 RARA ZNF143 HES1 RNF2 L3MBTL2 MTA2

Genomic Location for ADGRD1 Gene

130,953,907 bp from pter
131,141,469 bp from pter
187,563 bases
Plus strand

Genomic View for ADGRD1 Gene

Genes around ADGRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRD1 Gene

Proteins for ADGRD1 Gene

  • Protein details for ADGRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor D1
    Protein Accession:
    Secondary Accessions:
    • B2CKK9
    • B7ZLF7
    • Q2M1L3
    • Q6ZMQ1
    • Q7Z7M2
    • Q86SM4

    Protein attributes for ADGRD1 Gene

    874 amino acids
    Molecular mass:
    96530 Da
    Quaternary structure:
    No Data Available
    • The N-terminal domain and autocatalytic activity of ADGRD1 at the GPCR proteolysis site (GPS) are not required for G-protein coupling activity.

    Alternative splice isoforms for ADGRD1 Gene


neXtProt entry for ADGRD1 Gene

Post-translational modifications for ADGRD1 Gene

  • Glycosylation at Asn 90, Asn 185, Asn 282, Asn 302, Asn 319, Asn 394, Asn 476, Asn 501, and Asn 533
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ADGRD1 Gene

Domains & Families for ADGRD1 Gene

Gene Families for ADGRD1 Gene

Suggested Antigen Peptide Sequences for ADGRD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRD1: view

Function for ADGRD1 Gene

Molecular function for ADGRD1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Signals via G(s)-alpha family of G-proteins.

Gene Ontology (GO) - Molecular Function for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IDA,TAS 22025619
genes like me logo Genes that share ontologies with ADGRD1: view
genes like me logo Genes that share phenotypes with ADGRD1: view

Animal Models for ADGRD1 Gene

MGI Knock Outs for ADGRD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRD1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRD1 Gene

Localization for ADGRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRD1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRD1 gene
Compartment Confidence
plasma membrane 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 22025619
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
genes like me logo Genes that share ontologies with ADGRD1: view

Pathways & Interactions for ADGRD1 Gene

SuperPathways for ADGRD1 Gene

SuperPathway Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with ADGRD1: view

Pathways by source for ADGRD1 Gene

1 BioSystems pathway for ADGRD1 Gene

Interacting Proteins for ADGRD1 Gene

Selected Interacting proteins: Q6QNK2-AGRD1_HUMAN for ADGRD1 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA,TAS 22025619
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway IDA 22025619
genes like me logo Genes that share ontologies with ADGRD1: view

No data available for SIGNOR curated interactions for ADGRD1 Gene

Transcripts for ADGRD1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRD1 Gene

No ASD Table

Relevant External Links for ADGRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRD1 Gene

This gene is overexpressed in Liver (38.6), Heart (12.9), and Kidney (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRD1 Gene

Protein tissue co-expression partners for ADGRD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRD1 Gene:

genes like me logo Genes that share expression patterns with ADGRD1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRD1 Gene

Orthologs for ADGRD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GPR133 34
  • 99.13 (n)
(Bos Taurus)
Mammalia GPR133 34 35
  • 84.02 (n)
(Canis familiaris)
Mammalia GPR133 34 35
  • 81.67 (n)
(Rattus norvegicus)
Mammalia Gpr133 34
  • 79.27 (n)
(Mus musculus)
Mammalia Gpr133 34 35
  • 78.95 (n)
Adgrd1 16
(Ornithorhynchus anatinus)
Mammalia GPR133 35
  • 77 (a)
(Monodelphis domestica)
Mammalia GPR133 35
  • 71 (a)
(Gallus gallus)
Aves GPR133 34 35
  • 68.38 (n)
(Anolis carolinensis)
Reptilia -- 35
  • 6 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr133 34
  • 63.43 (n)
(Danio rerio)
Actinopterygii gpr133 34
  • 62 (n)
BX649292.1 35
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 35
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lat-2 35
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 15 (a)
Species where no ortholog for ADGRD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRD1 Gene

Gene Tree for ADGRD1 (if available)
Gene Tree for ADGRD1 (if available)

Paralogs for ADGRD1 Gene Pseudogenes for ADGRD1 Gene

genes like me logo Genes that share paralogs with ADGRD1: view

Variants for ADGRD1 Gene

Sequence variations from dbSNP and Humsavar for ADGRD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10082753 -- 131,047,429(+) GCAGC(C/T)CCGGG intron-variant
rs10160896 -- 131,038,385(+) CTGCC(A/G)CCTCC intron-variant
rs10219596 -- 130,979,156(+) GCGGT(A/G)ACCCA intron-variant
rs10219597 -- 130,979,181(+) CGGGA(A/G)GGCTG intron-variant
rs10526212 -- 130,979,862(+) CACAC(-/AC)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRD1 Gene

Variant ID Type Subtype PubMed ID
esv2746811 CNV deletion 23290073
esv2746810 CNV deletion 23290073
esv2746809 CNV deletion 23290073
esv2746806 CNV deletion 23290073
esv2746805 CNV deletion 23290073
esv2746804 CNV deletion 23290073
esv2746803 CNV deletion 23290073
esv2746802 CNV deletion 23290073
esv2743283 CNV deletion 23290073
esv2741756 CNV deletion 23290073
esv2676329 CNV deletion 23128226
esv2672456 CNV deletion 23128226
esv2656903 CNV deletion 23128226
esv24528 CNV loss 19812545
esv24428 CNV gain 19812545
esv23678 CNV gain 19812545
esv1383526 CNV deletion 17803354
esv1370689 CNV insertion 17803354
esv1356063 CNV deletion 17803354
esv1323340 CNV deletion 17803354
esv1279743 CNV insertion 17803354
esv1249867 CNV deletion 17803354
esv1092985 CNV insertion 17803354
esv1006538 CNV insertion 20482838
esv1004799 CNV deletion 20482838
dgv9e196 CNV deletion 17116639
dgv942e59 CNV duplication 20981092
dgv92e215 CNV deletion 23714750
dgv530e212 CNV gain 25503493
dgv314e214 CNV loss 21293372
dgv213e201 CNV deletion 23290073
dgv1580n100 CNV gain 25217958
esv3631225 CNV gain 21293372
esv3631223 CNV gain 21293372
esv3631222 CNV gain 21293372
esv3631220 CNV loss 21293372
esv3631218 CNV gain 21293372
esv3631216 CNV gain 21293372
esv3631215 CNV gain 21293372
esv3550039 CNV deletion 23714750
esv3424598 CNV insertion 20981092
esv27579 CNV loss 19812545
esv2746824 CNV deletion 23290073
esv2746823 CNV deletion 23290073
esv2746822 CNV deletion 23290073
esv2746821 CNV deletion 23290073
esv2746820 CNV deletion 23290073
esv2746818 CNV deletion 23290073
esv2746817 CNV deletion 23290073
esv2746815 CNV deletion 23290073
esv2746814 CNV deletion 23290073
esv2746813 CNV deletion 23290073
esv2746812 CNV deletion 23290073
nsv975539 CNV duplication 23825009
nsv940 CNV insertion 18451855
nsv820623 CNV duplication 20802225
nsv819999 CNV gain 19587683
nsv560769 CNV gain 21841781
nsv519628 CNV loss 19592680
nsv517271 CNV gain+loss 19592680
nsv477666 CNV novel sequence insertion 20440878
nsv1145888 CNV deletion 26484159
nsv1144664 CNV deletion 24896259
nsv1141387 CNV deletion 24896259
nsv1134280 CNV deletion 24896259
nsv1124831 CNV deletion 24896259
nsv1110692 CNV insertion 24896259
nsv1049950 CNV gain 25217958
nsv1040328 CNV gain 25217958
nsv1038008 CNV gain 25217958
esv991215 CNV deletion 20482838
esv990308 CNV deletion 20482838
esv3892282 CNV gain 25118596

Variation tolerance for ADGRD1 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRD1 Gene

Disorders for ADGRD1 Gene

Relevant External Links for ADGRD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADGRD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRD1 Gene

Publications for ADGRD1 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 64
  2. Cell adhesion receptor GPR133 couples to Gs protein. (PMID: 22025619) Bohnekamp J. … SchAPneberg T. (J. Biol. Chem. 2011) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PMID: 15203201) Bjarnadottir T.K. … Schioeth H.B. (Genomics 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ADGRD1 Gene

Sources for ADGRD1 Gene

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