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Aliases for ADGRD1 Gene

Aliases for ADGRD1 Gene

  • Adhesion G Protein-Coupled Receptor D1 2 3
  • GPR133 3 4 6
  • PGR25 3 4 6
  • G-Protein Coupled Receptor PGR25 3 4
  • G Protein-Coupled Receptor 133 2 3
  • Probable G-Protein Coupled Receptor 133 3

External Ids for ADGRD1 Gene

Previous Symbols for ADGRD1 Gene

  • GPR133

Summaries for ADGRD1 Gene

Entrez Gene Summary for ADGRD1 Gene

  • The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

GeneCards Summary for ADGRD1 Gene

ADGRD1 (Adhesion G Protein-Coupled Receptor D1) is a Protein Coding gene. Among its related pathways are GPCRs, Other. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRD1 Gene

  • Orphan receptor

Gene Wiki entry for ADGRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRD1 Gene

Genomics for ADGRD1 Gene

Genomic Location for ADGRD1 Gene

Start:
130,953,907 bp from pter
End:
131,141,469 bp from pter
Size:
187,563 bases
Orientation:
Plus strand

Genomic View for ADGRD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRD1 Gene

No data available for Regulatory Elements for ADGRD1 Gene

Proteins for ADGRD1 Gene

  • Protein details for ADGRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6QNK2-GP133_HUMAN
    Recommended name:
    Probable G-protein coupled receptor 133
    Protein Accession:
    Q6QNK2
    Secondary Accessions:
    • B2CKK9
    • B7ZLF7
    • Q2M1L3
    • Q6ZMQ1
    • Q7Z7M2
    • Q86SM4

    Protein attributes for ADGRD1 Gene

    Size:
    874 amino acids
    Molecular mass:
    96530 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADGRD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRD1 Gene

Proteomics data for ADGRD1 Gene at MOPED

Post-translational modifications for ADGRD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRD1 Gene

No data available for DME Specific Peptides for ADGRD1 Gene

Domains for ADGRD1 Gene

Gene Families for ADGRD1 Gene

HGNC:
  • GPCRBO :GPCR / Class B : Orphans

UniProtKB/Swiss-Prot:

GP133_HUMAN
Domain:
  • Contains 1 GPS domain.:
    • Q6QNK2
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • Q6QNK2
genes like me logo Genes that share domains with ADGRD1: view

Function for ADGRD1 Gene

Molecular function for ADGRD1 Gene

UniProtKB/Swiss-Prot Function: Orphan receptor

Gene Ontology (GO) - Molecular Function for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
genes like me logo Genes that share ontologies with ADGRD1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADGRD1 Gene

Localization for ADGRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRD1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRD1: view

Pathways for ADGRD1 Gene

SuperPathways for ADGRD1 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with ADGRD1: view

Pathways by source for ADGRD1 Gene

1 BioSystems pathway for ADGRD1 Gene

Interacting Proteins for ADGRD1 Gene

Gene Ontology (GO) - Biological Process for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRD1: view

Transcripts for ADGRD1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRD1 Gene

No ASD Table

Relevant External Links for ADGRD1 Gene

GeneLoc Exon Structure for
ADGRD1
ECgene alternative splicing isoforms for
ADGRD1

Expression for ADGRD1 Gene

mRNA expression in normal human tissues for ADGRD1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ADGRD1 Gene

genes like me logo Genes that share expressions with ADGRD1: view

Orthologs for ADGRD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR133 36
  • 99.13 (n)
  • 98.96 (a)
cow
(Bos Taurus)
Mammalia GPR133 36
  • 84.02 (n)
  • 82.07 (a)
GPR133 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR133 36
  • 81.67 (n)
  • 78.59 (a)
GPR133 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr133 36
  • 78.95 (n)
  • 80.83 (a)
Gpr133 16
Gpr133 37
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR133 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR133 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gpr133 36
  • 79.27 (n)
  • 79.77 (a)
chicken
(Gallus gallus)
Aves GPR133 36
  • 68.38 (n)
  • 69.3 (a)
GPR133 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 6 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr133 36
  • 63.43 (n)
  • 61.66 (a)
zebrafish
(Danio rerio)
Actinopterygii BX649292.1 37
  • 36 (a)
ManyToMany
gpr133 36
  • 62 (n)
  • 58.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 37
  • 9 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lat-2 37
  • 15 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 15 (a)
ManyToMany
Species with no ortholog for ADGRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRD1 Gene

ENSEMBL:
Gene Tree for ADGRD1 (if available)
TreeFam:
Gene Tree for ADGRD1 (if available)

Paralogs for ADGRD1 Gene

Pseudogenes.org Pseudogenes for ADGRD1 Gene

genes like me logo Genes that share paralogs with ADGRD1: view

Variants for ADGRD1 Gene

Sequence variations from dbSNP and Humsavar for ADGRD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2926 -- 130,986,525(-) ACTAA(C/T)GAGTG intron-variant
rs819117 -- 130,956,997(+) cacat(A/G)catac intron-variant
rs819118 -- 130,958,036(+) AACAA(A/C)ACATC intron-variant
rs819119 -- 130,958,261(+) ATGGC(A/G)TGATC intron-variant
rs819116 -- 130,956,884(+) atgca(C/T)acaca intron-variant

Relevant External Links for ADGRD1 Gene

HapMap Linkage Disequilibrium report
ADGRD1

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRD1 Gene

Disorders for ADGRD1 Gene

No disorders were found for ADGRD1 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRD1 Gene

Publications for ADGRD1 Gene

  1. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The human and mouse repertoire of the adhesion family of G-protein- coupled receptors. (PMID: 15203201) Bjarnadottir T.K. … Schioeth H.B. (Genomics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3

Products for ADGRD1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRD1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRD1
    • Block miRNA regulation of ADGRD1 using miScript Target Protectors

    Sources for ADGRD1 Gene

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