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Aliases for ADGRD1 Gene

Aliases for ADGRD1 Gene

  • Adhesion G Protein-Coupled Receptor D1 2 3 5
  • G-Protein Coupled Receptor PGR25 3 4
  • G Protein-Coupled Receptor 133 2 3
  • G-Protein Coupled Receptor 133 3 4
  • GPR133 3 4
  • PGR25 3 4
  • Probable G-Protein Coupled Receptor 133 3

External Ids for ADGRD1 Gene

Previous HGNC Symbols for ADGRD1 Gene

  • GPR133

Summaries for ADGRD1 Gene

Entrez Gene Summary for ADGRD1 Gene

  • The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

GeneCards Summary for ADGRD1 Gene

ADGRD1 (Adhesion G Protein-Coupled Receptor D1) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRG5.

UniProtKB/Swiss-Prot for ADGRD1 Gene

  • Orphan receptor. Signals via G(s)-alpha family of G-proteins.

Gene Wiki entry for ADGRD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRD1 Gene

Genomics for ADGRD1 Gene

Regulatory Elements for ADGRD1 Gene

Enhancers for ADGRD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRD1 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADGRD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRD1 Gene

130,953,907 bp from pter
131,141,469 bp from pter
187,563 bases
Plus strand

Genomic View for ADGRD1 Gene

Genes around ADGRD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRD1 Gene

Proteins for ADGRD1 Gene

  • Protein details for ADGRD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adhesion G-protein coupled receptor D1
    Protein Accession:
    Secondary Accessions:
    • B2CKK9
    • B7ZLF7
    • Q2M1L3
    • Q6ZMQ1
    • Q7Z7M2
    • Q86SM4

    Protein attributes for ADGRD1 Gene

    874 amino acids
    Molecular mass:
    96530 Da
    Quaternary structure:
    No Data Available
    • The N-terminal domain and autocatalytic activity of ADGRD1 at the GPCR proteolysis site (GPS) are not required for G-protein coupling activity.

    Alternative splice isoforms for ADGRD1 Gene


neXtProt entry for ADGRD1 Gene

Proteomics data for ADGRD1 Gene at MOPED

Post-translational modifications for ADGRD1 Gene

  • Glycosylation at Asn 90, Asn 185, Asn 282, Asn 302, Asn 319, Asn 394, Asn 476, Asn 501, and Asn 533
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRD1 Gene

No data available for DME Specific Peptides for ADGRD1 Gene

Domains & Families for ADGRD1 Gene

Gene Families for ADGRD1 Gene

Suggested Antigen Peptide Sequences for ADGRD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRD1: view

Function for ADGRD1 Gene

Molecular function for ADGRD1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor. Signals via G(s)-alpha family of G-proteins.
genes like me logo Genes that share phenotypes with ADGRD1: view

Animal Models for ADGRD1 Gene

MGI Knock Outs for ADGRD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRD1 Gene

Localization for ADGRD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRD1 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRD1: view

No data available for Subcellular locations from COMPARTMENTS for ADGRD1 Gene

Pathways & Interactions for ADGRD1 Gene

SuperPathways for ADGRD1 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with ADGRD1: view

Pathways by source for ADGRD1 Gene

1 BioSystems pathway for ADGRD1 Gene

Interacting Proteins for ADGRD1 Gene

Gene Ontology (GO) - Biological Process for ADGRD1 Gene


No data available for SIGNOR curated interactions for ADGRD1 Gene

Drugs & Compounds for ADGRD1 Gene

No Compound Related Data Available

Transcripts for ADGRD1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRD1 Gene

No ASD Table

Relevant External Links for ADGRD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGRD1 Gene

mRNA expression in normal human tissues for ADGRD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRD1 Gene

This gene is overexpressed in Liver (38.6), Heart (12.9), and Kidney (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRD1 Gene

genes like me logo Genes that share expression patterns with ADGRD1: view

Protein tissue co-expression partners for ADGRD1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRD1 Gene

Orthologs for ADGRD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia GPR133 35
  • 84.02 (n)
  • 82.07 (a)
GPR133 36
  • 79 (a)
(Canis familiaris)
Mammalia GPR133 35
  • 81.67 (n)
  • 78.59 (a)
GPR133 36
  • 78 (a)
(Mus musculus)
Mammalia Gpr133 35
  • 78.95 (n)
  • 80.83 (a)
Adgrd1 16
Gpr133 36
  • 78 (a)
(Pan troglodytes)
Mammalia GPR133 35
  • 99.13 (n)
  • 98.96 (a)
(Rattus norvegicus)
Mammalia Gpr133 35
  • 79.27 (n)
  • 79.77 (a)
(Monodelphis domestica)
Mammalia GPR133 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia GPR133 36
  • 77 (a)
(Gallus gallus)
Aves GPR133 35
  • 68.38 (n)
  • 69.3 (a)
GPR133 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 6 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr133 35
  • 63.43 (n)
  • 61.66 (a)
(Danio rerio)
Actinopterygii gpr133 35
  • 62 (n)
  • 58.36 (a)
BX649292.1 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cirl 36
  • 9 (a)
(Caenorhabditis elegans)
Secernentea lat-2 36
  • 15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 15 (a)
Species with no ortholog for ADGRD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRD1 Gene

Gene Tree for ADGRD1 (if available)
Gene Tree for ADGRD1 (if available)

Paralogs for ADGRD1 Gene Pseudogenes for ADGRD1 Gene

genes like me logo Genes that share paralogs with ADGRD1: view

Variants for ADGRD1 Gene

Sequence variations from dbSNP and Humsavar for ADGRD1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs11833801 - 131,076,849(+) TCTTC(A/C/G)TGTAC reference, missense
rs11061318 - 131,084,560(+) CTGGT(C/T)GAACC reference, missense
rs1965572 -- 131,069,514(-) CCCTG(C/T)GCCTG intron-variant
rs1969482 -- 130,958,290(+) tgccc(C/G)ctggg intron-variant
rs1976930 -- 131,091,900(-) AAGGC(A/G)CAGTG intron-variant

Variation tolerance for ADGRD1 Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRD1 Gene

Disorders for ADGRD1 Gene

Relevant External Links for ADGRD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADGRD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRD1 Gene

Publications for ADGRD1 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 67
  2. Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. (PMID: 24529757) Xie T. … Xu R. (Neurobiol. Aging 2014) 3
  3. Nucleolar protein trafficking in response to HIV-1 Tat: rewiring the nucleolus. (PMID: 23166591) Jarboui M.A. … Gautier V.W. (PLoS ONE 2012) 3
  4. Cell adhesion receptor GPR133 couples to Gs protein. (PMID: 22025619) Bohnekamp J. … SchAPneberg T. (J. Biol. Chem. 2011) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for ADGRD1 Gene

Sources for ADGRD1 Gene