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Aliases for ADGRB3 Gene

Aliases for ADGRB3 Gene

  • Adhesion G Protein-Coupled Receptor B3 2 3 5
  • Brain-Specific Angiogenesis Inhibitor 3 2 3 4
  • BAI3 3 4
  • DJ91B17.1 (Brain-Specific Angiogenesis Inhibitor 3) 3
  • KIAA0550 4

External Ids for ADGRB3 Gene

Previous HGNC Symbols for ADGRB3 Gene

  • BAI3

Summaries for ADGRB3 Gene

Entrez Gene Summary for ADGRB3 Gene

  • This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRB3 Gene

ADGRB3 (Adhesion G Protein-Coupled Receptor B3) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB2.

UniProtKB/Swiss-Prot for ADGRB3 Gene

  • Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).

Gene Wiki entry for ADGRB3 Gene

Additional gene information for ADGRB3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB3 Gene

Genomics for ADGRB3 Gene

Regulatory Elements for ADGRB3 Gene

Enhancers for ADGRB3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H068633 1.2 ENCODE dbSUPER 17.5 -0.2 -214 2 ZFP64 ZNF766 GLIS2 ELK1 ZNF202 ZC3H11A REST ZNF518A GLIS1 CTCF ADGRB3 LOC101928307
GH06H068761 0.8 FANTOM5 25.1 +126.3 126341 0 CTCF SMARCE1 ATF1 SOX6 REST RAD21 TCF12 CC2D1A SKIL SMARCA4 ADGRB3 GC06P068741 GC06P069165
GH06H068639 1.2 Ensembl ENCODE dbSUPER 11.2 +4.9 4912 1 SMARCE1 LEF1 PKNOX1 IRF2 TBL1XR1 ZNF740 ETV1 CEBPB DPF2 ELF1 ADGRB3 LOC101928307 GC06M068665
GH06H068717 0.7 ENCODE 7.3 +83.2 83184 0 SMARCE1 PKNOX1 ATF1 CAVIN1 SOX6 ZNF175 DPF2 ZNF592 NFIC POLR2A ADGRB3 GC06P068741 GC06M068665
GH06H068653 0.7 dbSUPER 6.4 +19.5 19498 2 BRD4 HDGF ATF1 ZBTB2 ARNT NRF1 NFRKB CDC5L ZBTB40 ATF2 ADGRB3 GC06M068665
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRB3 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRB3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000198595 19 2199 ZFP64 ZNF766 GLIS2 ELK1 ZNF202 ZC3H11A REST ZNF518A GLIS1 CTCF

Genomic Location for ADGRB3 Gene

Chromosome:
6
Start:
68,635,282 bp from pter
End:
69,389,511 bp from pter
Size:
754,230 bases
Orientation:
Plus strand

Genomic View for ADGRB3 Gene

Genes around ADGRB3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRB3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB3 Gene

Proteins for ADGRB3 Gene

  • Protein details for ADGRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60242-AGRB3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor B3
    Protein Accession:
    O60242
    Secondary Accessions:
    • B7Z1K0
    • O60297
    • Q2NKN6
    • Q5VY37
    • Q9BX54

    Protein attributes for ADGRB3 Gene

    Size:
    1522 amino acids
    Molecular mass:
    171518 Da
    Quaternary structure:
    • Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts (via TSP N-terminal domains) with C1QL1, C1QL2, C1QL3 and C1QL4 (PubMed:21262840). Interacts with ELMO1, ELMO2 AND ELMO3 (PubMed:24567399).
    Miscellaneous:
    • Autoproteolysis appears to be cell specific, does not readily undergo proteolytic cleavage in HEK293T cells.
    SequenceCaution:
    • Sequence=BAA25476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADGRB3 Gene

    Alternative splice isoforms for ADGRB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRB3 Gene

Post-translational modifications for ADGRB3 Gene

  • The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Glycosylation at Asn51, posLast=5454, posLast=8282, Asn105, posLast=241241, posLast=337337, posLast=418418, Asn540, posLast=625625, posLast=779779, Asn812, Asn828, and posLast=937937
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ADGRB3 Gene

Domains & Families for ADGRB3 Gene

Gene Families for ADGRB3 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Plasma proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADGRB3 Gene

Graphical View of Domain Structure for InterPro Entry

O60242

UniProtKB/Swiss-Prot:

AGRB3_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRB3: view

Function for ADGRB3 Gene

Molecular function for ADGRB3 Gene

UniProtKB/Swiss-Prot Function:
Receptor that plays a role in the regulation of synaptogenesis and dendritic spine formation at least partly via interaction with ELMO1 and RAC1 activity (By similarity). Promotes myoblast fusion through ELMO/DOCK1 (PubMed:24567399).

Phenotypes From GWAS Catalog for ADGRB3 Gene

Gene Ontology (GO) - Molecular Function for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA --
GO:0005096 GTPase activator activity ISS --
GO:0005515 protein binding IPI 21262840
genes like me logo Genes that share ontologies with ADGRB3: view
genes like me logo Genes that share phenotypes with ADGRB3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRB3

CRISPR Products

miRNA for ADGRB3 Gene

miRTarBase miRNAs that target ADGRB3

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADGRB3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRB3 Gene

Localization for ADGRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRB3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IPI 21262840
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
GO:0043083 synaptic cleft IEA --
GO:0098794 postsynapse IEA --
genes like me logo Genes that share ontologies with ADGRB3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADGRB3 Gene

Pathways & Interactions for ADGRB3 Gene

SuperPathways for ADGRB3 Gene

No Data Available

Interacting Proteins for ADGRB3 Gene

Gene Ontology (GO) - Biological Process for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007520 myoblast fusion IDA 24567399
GO:0016322 neuron remodeling IEA --
genes like me logo Genes that share ontologies with ADGRB3: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRB3 Gene

Drugs & Compounds for ADGRB3 Gene

No Compound Related Data Available

Transcripts for ADGRB3 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADGRB3
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB3 Gene

No ASD Table

Relevant External Links for ADGRB3 Gene

GeneLoc Exon Structure for
ADGRB3
ECgene alternative splicing isoforms for
ADGRB3

Expression for ADGRB3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRB3 Gene

Protein differential expression in normal tissues from HIPED for ADGRB3 Gene

This gene is overexpressed in Frontal cortex (37.4), Fetal Brain (22.1), and Serum (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB3 Gene



Protein tissue co-expression partners for ADGRB3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRB3 Gene:

ADGRB3

mRNA Expression by UniProt/SwissProt for ADGRB3 Gene:

O60242-AGRB3_HUMAN
Tissue specificity: Strongly expressed in brain. Also detected in heart. Reduced expression in some glioblastoma cell lines.

Evidence on tissue expression from TISSUES for ADGRB3 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with ADGRB3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRB3 Gene

Orthologs for ADGRB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI3 33 34
  • 99.69 (n)
oppossum
(Monodelphis domestica)
Mammalia BAI3 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAI3 33 34
  • 95.93 (n)
cow
(Bos Taurus)
Mammalia BAI3 33 34
  • 94.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 93 (a)
OneToMany
-- 34
  • 92 (a)
OneToMany
-- 34
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Bai3 33 34
  • 92.36 (n)
Adgrb3 16
rat
(Rattus norvegicus)
Mammalia Bai3 33
  • 91.79 (n)
chicken
(Gallus gallus)
Aves BAI3 33 34
  • 88.07 (n)
lizard
(Anolis carolinensis)
Reptilia BAI3 34
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bai3 33
  • 82.5 (n)
zebrafish
(Danio rerio)
Actinopterygii bai3 33 34
  • 73.55 (n)
fruit fly
(Drosophila melanogaster)
Insecta unc-5 34
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F14H12.3 34
  • 33 (a)
ManyToMany
mig-21 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
CSA.10960 34
  • 13 (a)
ManyToMany
-- 34
  • 12 (a)
ManyToMany
Species where no ortholog for ADGRB3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB3 Gene

ENSEMBL:
Gene Tree for ADGRB3 (if available)
TreeFam:
Gene Tree for ADGRB3 (if available)

Paralogs for ADGRB3 Gene

Paralogs for ADGRB3 Gene

genes like me logo Genes that share paralogs with ADGRB3: view

Variants for ADGRB3 Gene

Sequence variations from dbSNP and Humsavar for ADGRB3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000000843 -- 69,068,519(+) GGAAA(C/T)GATGT intron-variant, utr-variant-3-prime
rs1000000873 -- 68,783,161(+) TTACA(G/T)ATGAT intron-variant
rs1000002902 -- 68,682,572(+) AAATA(A/C)AAAAT intron-variant
rs1000005636 -- 68,900,050(+) AAGAC(A/C)CTGTC intron-variant
rs1000012128 -- 69,145,132(+) TGGGC(C/T)CACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRB3 Gene

Variant ID Type Subtype PubMed ID
dgv10755n54 CNV loss 21841781
dgv10756n54 CNV loss 21841781
dgv10757n54 CNV loss 21841781
dgv1797e212 CNV loss 25503493
dgv1798e212 CNV loss 25503493
dgv1799e212 CNV loss 25503493
dgv224n6 CNV deletion 16902084
dgv383n21 CNV loss 19592680
dgv384n21 CNV loss 19592680
esv1175489 CNV insertion 17803354
esv1455001 CNV insertion 17803354
esv2220750 CNV deletion 18987734
esv23558 CNV loss 19812545
esv2421691 CNV deletion 20811451
esv2572597 CNV insertion 19546169
esv26338 CNV loss 19812545
esv2655218 CNV deletion 19546169
esv2660306 CNV deletion 23128226
esv2667851 CNV deletion 23128226
esv2671118 CNV deletion 23128226
esv2674847 CNV deletion 23128226
esv2678369 CNV deletion 23128226
esv2732249 CNV deletion 23290073
esv2732252 CNV deletion 23290073
esv2759440 CNV gain 17122850
esv28766 CNV loss 19812545
esv3304980 CNV mobile element insertion 20981092
esv3305345 CNV mobile element insertion 20981092
esv3306287 CNV mobile element insertion 20981092
esv3309025 CNV mobile element insertion 20981092
esv3310461 CNV novel sequence insertion 20981092
esv3310530 CNV novel sequence insertion 20981092
esv3335919 CNV duplication 20981092
esv3352522 CNV insertion 20981092
esv3365467 CNV insertion 20981092
esv3367046 CNV duplication 20981092
esv3368681 CNV duplication 20981092
esv3383290 CNV insertion 20981092
esv3413963 CNV insertion 20981092
esv3415888 CNV insertion 20981092
esv3437843 CNV insertion 20981092
esv3449074 CNV insertion 20981092
esv3539926 CNV deletion 23714750
esv3539928 CNV deletion 23714750
esv3609387 CNV loss 21293372
esv3609388 CNV loss 21293372
esv3609389 CNV loss 21293372
esv3609390 CNV loss 21293372
esv3609392 CNV loss 21293372
esv3609397 CNV loss 21293372
esv3609398 CNV loss 21293372
esv3609399 CNV gain 21293372
esv3609401 CNV loss 21293372
esv3609403 CNV loss 21293372
esv3849 CNV loss 18987735
esv3890876 CNV loss 25118596
esv996288 CNV insertion 20482838
nsv1015906 CNV gain 25217958
nsv1017659 CNV gain 25217958
nsv1020792 CNV loss 25217958
nsv1025548 CNV loss 25217958
nsv1029637 CNV gain 25217958
nsv1114838 CNV deletion 24896259
nsv1117643 CNV deletion 24896259
nsv1124088 CNV deletion 24896259
nsv1128257 CNV deletion 24896259
nsv1143153 CNV tandem duplication 24896259
nsv463148 CNV loss 19166990
nsv470831 CNV loss 18288195
nsv499697 CNV loss 21111241
nsv514367 CNV loss 21397061
nsv514368 CNV loss 21397061
nsv517304 CNV loss 19592680
nsv526130 CNV gain 19592680
nsv528106 CNV gain 19592680
nsv5337 CNV deletion 18451855
nsv5338 CNV deletion 18451855
nsv5339 CNV insertion 18451855
nsv603620 CNV loss 21841781
nsv603621 CNV loss 21841781
nsv603634 CNV loss 21841781
nsv603635 CNV loss 21841781
nsv823724 CNV gain 20364138
nsv823725 CNV gain 20364138
nsv830680 CNV gain 17160897
nsv956966 CNV deletion 24416366
nsv970365 CNV deletion 23825009

Variation tolerance for ADGRB3 Gene

Residual Variation Intolerance Score: 1.57% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRB3 Gene

Human Gene Mutation Database (HGMD)
ADGRB3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRB3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRB3 Gene

Disorders for ADGRB3 Gene

Relevant External Links for ADGRB3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRB3

No disorders were found for ADGRB3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRB3 Gene

Publications for ADGRB3 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T … Tokino T (Cytogenetics and cell genetics 1997) 2 3 4 22 60
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 60
  3. G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates. (PMID: 24567399) Hamoud N … Côté JF (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 60
  4. The cell-adhesion G protein-coupled receptor BAI3 is a high-affinity receptor for C1q-like proteins. (PMID: 21262840) Bolliger MF … Südhof TC (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 60
  5. The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. (PMID: 18628273) DeRosse P … Malhotra AK (Schizophrenia bulletin 2008) 3 22 60

Products for ADGRB3 Gene

Sources for ADGRB3 Gene

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