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Aliases for ADGRB3 Gene

Aliases for ADGRB3 Gene

  • Adhesion G Protein-Coupled Receptor B3 2 3
  • BAI3 3 4 6
  • Brain-Specific Angiogenesis Inhibitor 3 2 3
  • DJ91B17.1 (Brain-Specific Angiogenesis Inhibitor 3) 3
  • KIAA0550 4

External Ids for ADGRB3 Gene

Previous Symbols for ADGRB3 Gene

  • BAI3

Summaries for ADGRB3 Gene

Entrez Gene Summary for ADGRB3 Gene

  • This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRB3 Gene

ADGRB3 (Adhesion G Protein-Coupled Receptor B3) is a Protein Coding gene. An important paralog of this gene is UNC5D.

UniProtKB/Swiss-Prot for ADGRB3 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma

Gene Wiki entry for ADGRB3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB3 Gene

Genomics for ADGRB3 Gene

Genomic Location for ADGRB3 Gene

Start:
68,635,318 bp from pter
End:
69,389,511 bp from pter
Size:
754,194 bases
Orientation:
Plus strand

Genomic View for ADGRB3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRB3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB3 Gene

No data available for Regulatory Elements for ADGRB3 Gene

Proteins for ADGRB3 Gene

  • Protein details for ADGRB3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60242-BAI3_HUMAN
    Recommended name:
    Brain-specific angiogenesis inhibitor 3
    Protein Accession:
    O60242
    Secondary Accessions:
    • B7Z1K0
    • O60297
    • Q2NKN6
    • Q5VY37
    • Q9BX54

    Protein attributes for ADGRB3 Gene

    Size:
    1522 amino acids
    Molecular mass:
    171518 Da
    Quaternary structure:
    • Interacts with C1QL1, C1QL2, C1QL3 and C1QL4.
    SequenceCaution:
    • Sequence=BAA25476.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADGRB3 Gene

    Alternative splice isoforms for ADGRB3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRB3 Gene

Proteomics data for ADGRB3 Gene at MOPED

Post-translational modifications for ADGRB3 Gene

  • The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Does not undergo autocatalytic cleavage (in vitro).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRB3 Gene

No data available for DME Specific Peptides for ADGRB3 Gene

Domains for ADGRB3 Gene

Gene Families for ADGRB3 Gene

HGNC:
  • GPCRBO :GPCR / Class B : Orphans

UniProtKB/Swiss-Prot:

BAI3_HUMAN
Domain:
  • Contains 1 CUB domain.:
    • O60242
  • Contains 1 GPS domain.:
    • O60242
  • Contains 4 TSP type-1 domains.:
    • O60242
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • O60242
genes like me logo Genes that share domains with ADGRB3: view

Function for ADGRB3 Gene

Molecular function for ADGRB3 Gene

UniProtKB/Swiss-Prot Function: May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Might be involved in angiogenesis inhibition and suppression of glioblastoma

Gene Ontology (GO) - Molecular Function for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ADGRB3: view

Phenotypes for ADGRB3 Gene

genes like me logo Genes that share phenotypes with ADGRB3: view

miRNA for ADGRB3 Gene

miRTarBase miRNAs that target ADGRB3

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADGRB3 Gene

Localization for ADGRB3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB3 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRB3: view

Pathways for ADGRB3 Gene

SuperPathways for ADGRB3 Gene

No Data Available

Interacting Proteins for ADGRB3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000359630%0d%0a9606.ENSP00000386772%0d%0a9606.ENSP00000362987%0d%0a
Selected Interacting proteins: ENSP00000359630 O60242-BAI3_HUMAN for ADGRB3 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for ADGRB3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
GO:0016525 negative regulation of angiogenesis IEA --
genes like me logo Genes that share ontologies with ADGRB3: view

No data available for Pathways by source for ADGRB3 Gene

Transcripts for ADGRB3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB3 Gene

No ASD Table

Relevant External Links for ADGRB3 Gene

GeneLoc Exon Structure for
ADGRB3
ECgene alternative splicing isoforms for
ADGRB3

Expression for ADGRB3 Gene

mRNA expression in normal human tissues for ADGRB3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRB3 Gene

mRNA Expression by UniProt/SwissProt for ADGRB3 Gene

O60242-BAI3_HUMAN
Tissue specificity: Strongly expressed in brain. Also detected in heart. Reduced expression is observed in some glioblastoma cell lines
genes like me logo Genes that share expressions with ADGRB3: view

Orthologs for ADGRB3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI3 36
  • 99.69 (n)
  • 99.87 (a)
BAI3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAI3 36
  • 94.19 (n)
  • 97.99 (a)
BAI3 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAI3 36
  • 95.93 (n)
  • 98.55 (a)
BAI3 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bai3 36
  • 92.36 (n)
  • 98.42 (a)
Bai3 16
Bai3 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAI3 37
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 93 (a)
OneToMany
-- 37
  • 83 (a)
OneToMany
-- 37
  • 92 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Bai3 36
  • 91.79 (n)
  • 98.03 (a)
chicken
(Gallus gallus)
Aves BAI3 36
  • 88.07 (n)
  • 94.87 (a)
BAI3 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia BAI3 37
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia bai3 36
  • 82.5 (n)
  • 88.74 (a)
zebrafish
(Danio rerio)
Actinopterygii bai3 36
  • 73.55 (n)
  • 79.15 (a)
bai3 37
  • 80 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-5 37
  • 14 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F14H12.3 37
  • 33 (a)
ManyToMany
mig-21 37
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 12 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 28 (a)
ManyToMany
-- 37
  • 34 (a)
ManyToMany
CSA.10960 37
  • 13 (a)
ManyToMany
Species with no ortholog for ADGRB3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB3 Gene

ENSEMBL:
Gene Tree for ADGRB3 (if available)
TreeFam:
Gene Tree for ADGRB3 (if available)

Paralogs for ADGRB3 Gene

Paralogs for ADGRB3 Gene

genes like me logo Genes that share paralogs with ADGRB3: view

Variants for ADGRB3 Gene

Sequence variations from dbSNP and Humsavar for ADGRB3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs16669 -- 68,818,946(+) TGTGT(-/AA)AACAT intron-variant
rs67807 -- 69,138,075(+) gaaac(A/G)gtacc intron-variant
rs314190 -- 69,126,706(-) taggt(A/G)tgtct intron-variant
rs314191 -- 69,090,859(+) GAAAT(A/T)AGCTT intron-variant
rs314192 -- 69,092,501(+) CACAG(A/G)AAGTT intron-variant

Relevant External Links for ADGRB3 Gene

HapMap Linkage Disequilibrium report
ADGRB3

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRB3 Gene

Disorders for ADGRB3 Gene

No disorders were found for ADGRB3 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRB3 Gene

Publications for ADGRB3 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T. … Tokino T. (Cytogenet. Cell Genet. 1997) 2 3 4 23
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The genetics of symptom-based phenotypes: toward a molecular classification of schizophrenia. (PMID: 18628273) DeRosse P. … Malhotra A.K. (Schizophr Bull 2008) 3 23
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for ADGRB3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRB3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRB3
    • Block miRNA regulation of ADGRB3 using miScript Target Protectors
    • antibodies-online proteins for ADGRB3
    • antibodies-online antibodies for ADGRB3
    • antibodies-online kits for ADGRB3

    Sources for ADGRB3 Gene

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