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Aliases for ADGRB2 Gene

Aliases for ADGRB2 Gene

  • Adhesion G Protein-Coupled Receptor B2 2 3 5
  • Brain-Specific Angiogenesis Inhibitor 2 2 3 4
  • BAI2 3 4

External Ids for ADGRB2 Gene

Previous HGNC Symbols for ADGRB2 Gene

  • BAI2

Summaries for ADGRB2 Gene

Entrez Gene Summary for ADGRB2 Gene

  • This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for ADGRB2 Gene

ADGRB2 (Adhesion G Protein-Coupled Receptor B2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB3.

UniProtKB/Swiss-Prot for ADGRB2 Gene

  • Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).

Gene Wiki entry for ADGRB2 Gene

Additional gene information for ADGRB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB2 Gene

Genomics for ADGRB2 Gene

GeneHancer (GH) Regulatory Elements for ADGRB2 Gene

Promoters and enhancers for ADGRB2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I031763 Promoter/Enhancer 1.8 EPDnew Ensembl dbSUPER 550.8 +0.9 892 1.2 HDGF RB1 ZNF2 ZNF335 GLIS2 ZNF366 EGR2 ZNF398 REST ZEB2 ADGRB2 CCDC28B MIR4254
GH01I031711 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 32.6 +51.1 51086 4.8 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF121 ZNF143 ADGRB2 PEF1 ENSG00000235790 LOC105378626 TINAGL1 SERINC2 COL16A1 SPOCD1 GC01P031741
GH01I031699 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 20.7 +62.1 62113 6.7 SMAD1 FOXA2 MLX ARID4B DMAP1 E2F8 ZNF143 FOS DEK SP5 COL16A1 ENSG00000235790 ADGRB2 SNRNP40 PEF1 TINAGL1 LOC105378626 TSSK3 MTMR9LP GC01M031668
GH01I031780 Enhancer 1.3 Ensembl ENCODE dbSUPER 19.4 -17.4 -17379 2.9 HDGF PKNOX1 ATF1 ARNT TCF12 GATA2 ATF7 ZNF263 NCOA1 REST ADGRB2 COL16A1 ENSG00000254545 GC01M031767
GH01I031572 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.3 +189.3 189273 6.1 PKNOX1 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF143 FOS SP5 ZHX2 TINAGL1 ZBTB8B SNRNP40 TSSK3 TXLNA TMEM39B ADGRB2 KHDRBS1 FAM229A IQCC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ADGRB2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ADGRB2 Gene

Genomic Locations for ADGRB2 Gene
chr1:31,727,105-31,764,893
(GRCh38/hg38)
Size:
37,789 bases
Orientation:
Minus strand
chr1:32,192,718-32,230,494
(GRCh37/hg19)

Genomic View for ADGRB2 Gene

Genes around ADGRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB2 Gene

Proteins for ADGRB2 Gene

  • Protein details for ADGRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60241-AGRB2_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor B2
    Protein Accession:
    O60241
    Secondary Accessions:
    • B9EGK9
    • Q5T6K0
    • Q8NGW8
    • Q96GZ9

    Protein attributes for ADGRB2 Gene

    Size:
    1585 amino acids
    Molecular mass:
    172656 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2 (By similarity). Interacts (via carboxy-terminus) with TAX1BP3 (PubMed:21787750). Interacts with GNAZ (PubMed:28891236). Interacts with SH3GL2 (PubMed:28891236).
    SequenceCaution:
    • Sequence=BAA25362.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16890.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRB2 Gene

Post-translational modifications for ADGRB2 Gene

  • Autoproteolytic processes at the GPS domain; this cleavage modulates receptor activity. Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment.
  • Glycosylated.
  • Glycosylation at Asn106, Asn191, posLast=192192, posLast=356356, posLast=437437, Asn560, posLast=645645, and Asn867

No data available for DME Specific Peptides for ADGRB2 Gene

Domains & Families for ADGRB2 Gene

Gene Families for ADGRB2 Gene

HGNC:
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

O60241

UniProtKB/Swiss-Prot:

AGRB2_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRB2: view

Function for ADGRB2 Gene

Molecular function for ADGRB2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Receptor activity is regulated by proteolytic processing. The long N-terminal has a an inhibitory effect on the constitutive signaling activity. Removal of the N-terminal region induces an increase of the receptor activity.
UniProtKB/Swiss-Prot Function:
Orphan G-protein coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G-protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity).

Phenotypes From GWAS Catalog for ADGRB2 Gene

Gene Ontology (GO) - Molecular Function for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IMP,TAS 28891236
GO:0005515 protein binding IPI 28891236
genes like me logo Genes that share ontologies with ADGRB2: view
genes like me logo Genes that share phenotypes with ADGRB2: view

Animal Models for ADGRB2 Gene

MGI Knock Outs for ADGRB2:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRB2 Gene

Localization for ADGRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRB2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005813 centrosome IDA --
GO:0005886 plasma membrane IEA,IDA 28891236
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

Pathways & Interactions for ADGRB2 Gene

SuperPathways for ADGRB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IDA 28891236
GO:0007422 peripheral nervous system development IEA --
GO:0016525 negative regulation of angiogenesis IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRB2 Gene

Drugs & Compounds for ADGRB2 Gene

No Compound Related Data Available

Transcripts for ADGRB2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - - - - - -
SP9: -
SP10: -
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:

ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ADGRB2 Gene

GeneLoc Exon Structure for
ADGRB2
ECgene alternative splicing isoforms for
ADGRB2

Expression for ADGRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRB2 Gene

This gene is overexpressed in Cerebrospinal fluid (57.4) and Vitreous humor (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB2 Gene



Protein tissue co-expression partners for ADGRB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRB2 Gene:

ADGRB2

mRNA Expression by UniProt/SwissProt for ADGRB2 Gene:

O60241-AGRB2_HUMAN
Tissue specificity: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Evidence on tissue expression from TISSUES for ADGRB2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with ADGRB2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRB2 Gene

Orthologs for ADGRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI2 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia BAI2 33 34
  • 92.77 (n)
cow
(Bos Taurus)
Mammalia BAI2 33 34
  • 92.14 (n)
rat
(Rattus norvegicus)
Mammalia Bai2 33
  • 90.65 (n)
mouse
(Mus musculus)
Mammalia Bai2 33 34
  • 89.95 (n)
Adgrb2 16
platypus
(Ornithorhynchus anatinus)
Mammalia BAI2 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 46 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BAI2 33 34
  • 75.17 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 69 (a)
OneToMany
-- 34
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bai2 33
  • 67.09 (n)
zebrafish
(Danio rerio)
Actinopterygii BAI2 34
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-5 34
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T21B6.3 34
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5741 34
  • 22 (a)
ManyToMany
Species where no ortholog for ADGRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB2 Gene

ENSEMBL:
Gene Tree for ADGRB2 (if available)
TreeFam:
Gene Tree for ADGRB2 (if available)

Paralogs for ADGRB2 Gene

Paralogs for ADGRB2 Gene

genes like me logo Genes that share paralogs with ADGRB2: view

Variants for ADGRB2 Gene

Sequence variations from dbSNP and Humsavar for ADGRB2 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs778361520 likely-pathogenic, Progressive spastic paraparesis 31,728,621(-) G/A coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000245649 -- 31,730,894(-) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000296450 -- 31,730,637(-) A/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000296809 -- 31,743,057(-) C/G/T intron_variant
rs1000351829 -- 31,731,497(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRB2 Gene

Variant ID Type Subtype PubMed ID
esv2758930 CNV loss 17122850
nsv1007390 CNV gain 25217958
nsv1007786 CNV gain 25217958
nsv1121760 CNV deletion 24896259
nsv461028 CNV loss 19166990
nsv545953 CNV loss 21841781
nsv950385 CNV deletion 24416366

Variation tolerance for ADGRB2 Gene

Residual Variation Intolerance Score: 5.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ADGRB2 Gene

Human Gene Mutation Database (HGMD)
ADGRB2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRB2 Gene

Disorders for ADGRB2 Gene

Additional Disease Information for ADGRB2

No disorders were found for ADGRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRB2 Gene

Publications for ADGRB2 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T … Tokino T (Cytogenetics and cell genetics 1997) 2 3 4 22 58
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J … Schiöth HB (Pharmacological reviews 2015) 2 3 4 58
  3. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. (PMID: 28891236) Purcell RH … Hall RA (Human mutation 2017) 3 4 58
  4. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. (PMID: 21787750) Zencir S … Mohanty S (Biochemical and biophysical research communications 2011) 3 4 58
  5. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. (PMID: 20367554) Okajima D … Yokota H (Journal of receptor and signal transduction research 2010) 3 4 58

Products for ADGRB2 Gene

Sources for ADGRB2 Gene

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