Aliases for ADGRB2 Gene
External Ids for ADGRB2 Gene
Previous HGNC Symbols for ADGRB2 Gene
This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
GeneCards Summary for ADGRB2 Gene
ADGRB2 (Adhesion G Protein-Coupled Receptor B2) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is THBS4.
UniProtKB/Swiss-Prot for ADGRB2 Gene
Orphan receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT signaling pathway probably via a G-protein dependent pathway (PubMed:20367554). Might be involved in angiogenesis inhibition (By similarity).