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Aliases for ADGRB2 Gene

Aliases for ADGRB2 Gene

  • Adhesion G Protein-Coupled Receptor B2 2 3
  • BAI2 3 4 6
  • Brain-Specific Angiogenesis Inhibitor 2 2 3

External Ids for ADGRB2 Gene

Previous Symbols for ADGRB2 Gene

  • BAI2

Summaries for ADGRB2 Gene

Entrez Gene Summary for ADGRB2 Gene

  • This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for ADGRB2 Gene

ADGRB2 (Adhesion G Protein-Coupled Receptor B2) is a Protein Coding gene. An important paralog of this gene is UNC5D.

UniProtKB/Swiss-Prot for ADGRB2 Gene

  • Might be involved in angiogenesis inhibition

Gene Wiki entry for ADGRB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB2 Gene

Genomics for ADGRB2 Gene

Genomic Location for ADGRB2 Gene

Start:
31,727,111 bp from pter
End:
31,764,893 bp from pter
Size:
37,783 bases
Orientation:
Minus strand

Genomic View for ADGRB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB2 Gene

No data available for Regulatory Elements for ADGRB2 Gene

Proteins for ADGRB2 Gene

  • Protein details for ADGRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60241-BAI2_HUMAN
    Recommended name:
    Brain-specific angiogenesis inhibitor 2
    Protein Accession:
    O60241
    Secondary Accessions:
    • B9EGK9
    • Q5T6K0
    • Q8NGW8
    • Q96GZ9

    Protein attributes for ADGRB2 Gene

    Size:
    1585 amino acids
    Molecular mass:
    172656 Da
    Quaternary structure:
    • Interacts with GABPB2.
    SequenceCaution:
    • Sequence=BAA25362.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16890.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRB2 Gene

Proteomics data for ADGRB2 Gene at MOPED

Post-translational modifications for ADGRB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRB2 Gene

Domains for ADGRB2 Gene

Gene Families for ADGRB2 Gene

HGNC:
  • GPCRBO :GPCR / Class B : Orphans

UniProtKB/Swiss-Prot:

BAI2_HUMAN
Domain:
  • Contains 1 GPS domain.:
    • O60241
  • Contains 4 TSP type-1 domains.:
    • O60241
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.:
    • O60241
genes like me logo Genes that share domains with ADGRB2: view

Function for ADGRB2 Gene

Molecular function for ADGRB2 Gene

UniProtKB/Swiss-Prot Function: Might be involved in angiogenesis inhibition

Gene Ontology (GO) - Molecular Function for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ADGRB2: view

Phenotypes for ADGRB2 Gene

MGI mutant phenotypes for ADGRB2:
inferred from 1 alleles
GenomeRNAi human phenotypes for ADGRB2:
genes like me logo Genes that share phenotypes with ADGRB2: view

miRNA for ADGRB2 Gene

miRTarBase miRNAs that target ADGRB2

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADGRB2 Gene

Localization for ADGRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB2 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

Pathways for ADGRB2 Gene

SuperPathways for ADGRB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
GO:0007422 peripheral nervous system development IEA --
GO:0016525 negative regulation of angiogenesis IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

No data available for Pathways by source for ADGRB2 Gene

Transcripts for ADGRB2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB2 Gene

No ASD Table

Relevant External Links for ADGRB2 Gene

GeneLoc Exon Structure for
ADGRB2
ECgene alternative splicing isoforms for
ADGRB2

Expression for ADGRB2 Gene

mRNA expression in normal human tissues for ADGRB2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRB2 Gene

mRNA Expression by UniProt/SwissProt for ADGRB2 Gene

O60241-BAI2_HUMAN
Tissue specificity: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines
genes like me logo Genes that share expressions with ADGRB2: view

Orthologs for ADGRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI2 36
  • 99.55 (n)
  • 99.68 (a)
BAI2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAI2 36
  • 92.14 (n)
  • 96.59 (a)
BAI2 37
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAI2 36
  • 92.77 (n)
  • 97.4 (a)
BAI2 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bai2 36
  • 89.95 (n)
  • 95.27 (a)
Bai2 16
Bai2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 33 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia BAI2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bai2 36
  • 90.65 (n)
  • 96.33 (a)
chicken
(Gallus gallus)
Aves BAI2 36
  • 75.17 (n)
  • 75.2 (a)
BAI2 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 62 (a)
OneToMany
-- 37
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bai2 36
  • 67.09 (n)
  • 69.53 (a)
zebrafish
(Danio rerio)
Actinopterygii BAI2 37
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-5 37
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T21B6.3 37
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5741 37
  • 22 (a)
ManyToMany
Species with no ortholog for ADGRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB2 Gene

ENSEMBL:
Gene Tree for ADGRB2 (if available)
TreeFam:
Gene Tree for ADGRB2 (if available)

Paralogs for ADGRB2 Gene

Paralogs for ADGRB2 Gene

genes like me logo Genes that share paralogs with ADGRB2: view

Variants for ADGRB2 Gene

Sequence variations from dbSNP and Humsavar for ADGRB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs909001 -- 31,731,046(+) CCCTC(C/G/T)GGCCG synonymous-codon, reference
rs1043163 -- 31,727,366(-) TTTCA(A/C)ACTCC utr-variant-3-prime
rs1043171 -- 31,727,229(-) TGTTT(C/T)TCAGA utr-variant-3-prime
rs1043175 -- 31,727,225(-) TCTCA(A/G)AGGCC utr-variant-3-prime
rs1127100 -- 31,728,046(-) GGGGC(A/G)GCCGA reference, synonymous-codon, intron-variant

Relevant External Links for ADGRB2 Gene

HapMap Linkage Disequilibrium report
ADGRB2

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGRB2 Gene

Disorders for ADGRB2 Gene

No disorders were found for ADGRB2 Gene.

No data available for UniProtKB/Swiss-Prot for ADGRB2 Gene

Publications for ADGRB2 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T. … Tokino T. (Cytogenet. Cell Genet. 1997) 2 3 4 23
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. (PMID: 16412436) Jeong B.C. … Kim K.K. (FEBS Lett. 2006) 3 23
  5. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. (PMID: 10964907) Kreienkamp H.J. … Bockers T.M. (J. Biol. Chem. 2000) 3

Products for ADGRB2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRB2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRB2
    • Block miRNA regulation of ADGRB2 using miScript Target Protectors
    • antibodies-online proteins for ADGRB2
    • antibodies-online antibodies for ADGRB2
    • antibodies-online kits for ADGRB2

    Sources for ADGRB2 Gene

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