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ADGRB2 Gene(Protein Coding)

Adhesion G Protein-Coupled Receptor B2

GCID:
GC01M031727
GIFtS:
45
Genes Participants
UDN Logo

Aliases for ADGRB2 Gene

Aliases for ADGRB2 Gene

  • Adhesion G Protein-Coupled Receptor B2 2 3 5
  • Brain-Specific Angiogenesis Inhibitor 2 2 3 4
  • BAI2 3 4

External Ids for ADGRB2 Gene

Previous HGNC Symbols for ADGRB2 Gene

  • BAI2

Summaries for ADGRB2 Gene

Entrez Gene Summary for ADGRB2 Gene

  • This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for ADGRB2 Gene

ADGRB2 (Adhesion G Protein-Coupled Receptor B2) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is THBS4.

UniProtKB/Swiss-Prot for ADGRB2 Gene

  • Orphan receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT signaling pathway probably via a G-protein dependent pathway (PubMed:20367554). Might be involved in angiogenesis inhibition (By similarity).

Gene Wiki entry for ADGRB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB2 Gene

Genomics for ADGRB2 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ADGRB2 Gene

Enhancers for ADGRB2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRB2 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADGRB2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRB2 Gene

Chromosome:
1
Start:
31,727,105 bp from pter
End:
31,764,893 bp from pter
Size:
37,789 bases
Orientation:
Minus strand

Genomic View for ADGRB2 Gene

Genes around ADGRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRB2 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGRB2 Gene

Proteins for ADGRB2 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADGRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60241-AGRB2_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor B2
    Protein Accession:
    O60241
    Secondary Accessions:
    • B9EGK9
    • Q5T6K0
    • Q8NGW8
    • Q96GZ9

    Protein attributes for ADGRB2 Gene

    Size:
    1585 amino acids
    Molecular mass:
    172656 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2 (By similarity). Interacts (via carboxy-terminus) with TAX1BP3 (PubMed:21787750).
    SequenceCaution:
    • Sequence=BAA25362.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16890.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRB2 Gene

Proteomics data for ADGRB2 Gene at MOPED

Protein Expression for ADGRB2 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADGRB2 Gene

  • Glycosylated.
  • Proteolytically cleaved at 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment.
  • Glycosylation at Asn 106, Asn 191, Asn 192, Asn 356, Asn 437, Asn 560, Asn 645, and Asn 867
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRB2 Gene

Domains & Families for ADGRB2 Gene

Gene Families for ADGRB2 Gene

HGNC:

Protein Domains for ADGRB2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O60241

UniProtKB/Swiss-Prot:

AGRB2_HUMAN :
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Domain:
  • Contains 1 GPS domain.
  • Contains 4 TSP type-1 domains.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRB2: view

Function for ADGRB2 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ADGRB2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Displays increased activity following removal of N-terminal regions (mimicking the situation after proteolytic cleavage in the GPS domain and N-terminal fragment release).
UniProtKB/Swiss-Prot Function:
Orphan receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT signaling pathway probably via a G-protein dependent pathway (PubMed:20367554). Might be involved in angiogenesis inhibition (By similarity).

Gene Ontology (GO) - Molecular Function for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

Phenotypes for ADGRB2 Gene

MGI mutant phenotypes for ADGRB2:
inferred from 1 alleles
GenomeRNAi human phenotypes for ADGRB2:
genes like me logo Genes that share phenotypes with ADGRB2: view

Animal Models for ADGRB2 Gene

MGI Knock Outs for ADGRB2:

Animal Model Products

miRNA for ADGRB2 Gene

miRTarBase miRNAs that target ADGRB2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRB2 Gene

Localization for ADGRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB2 Gene

Cell membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRB2 Gene

Pathways & Interactions for ADGRB2 Gene

SuperPathways for ADGRB2 Gene

PathCards logoMore details on SuperPathways for ADGRB2
No Data Available

Gene Ontology (GO) - Biological Process for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0051965 positive regulation of synapse assembly IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRB2 Gene

Drugs & Compounds for ADGRB2 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ADGRB2 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ADGRB2 Gene

(15) REFSEQ mRNAs :
(86) Selected AceView cDNA sequences:
(15) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - - - - - -
SP9: -
SP10: -
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:

ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ADGRB2 Gene

GeneLoc Exon Structure for
ADGRB2
ECgene alternative splicing isoforms for
ADGRB2

Expression for ADGRB2 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ADGRB2 Gene

mRNA expression in normal human tissues for ADGRB2 Gene
mRNA expression by GTEx for ADGRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRB2 Gene

This gene is overexpressed in Cerebrospinal fluid (57.4) and Vitreous humor (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB2 Gene



mRNA Expression by UniProt/SwissProt for ADGRB2 Gene

O60241-AGRB2_HUMAN
Tissue specificity: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.
genes like me logo Genes that share expression patterns with ADGRB2: view

Protein tissue co-expression partners for ADGRB2 Gene

- Elite partner

No data available for mRNA differential expression in normal tissues for ADGRB2 Gene

Orthologs for ADGRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia BAI2 35
  • 92.14 (n)
  • 96.59 (a)
BAI2 36
  • 94 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia BAI2 35
  • 92.77 (n)
  • 97.4 (a)
BAI2 36
  • 97 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Bai2 35
  • 89.95 (n)
  • 95.27 (a)
Adgrb2 16
Bai2 36
  • 96 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia BAI2 35
  • 99.55 (n)
  • 99.68 (a)
BAI2 36
  • 100 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Bai2 35
  • 90.65 (n)
  • 96.33 (a)
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 33 (a)
 ManyToMany
-- 36
  • 46 (a)
 ManyToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia BAI2 36
  • 72 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves BAI2 35
  • 75.17 (n)
  • 75.2 (a)
BAI2 36
  • 73 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 62 (a)
 OneToMany
-- 36
  • 69 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia bai2 35
  • 67.09 (n)
  • 69.53 (a)
zebrafish
(Danio rerio)
 Actinopterygii BAI2 36
  • 61 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta unc-5 36
  • 15 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea T21B6.3 36
  • 16 (a)
 ManyToMany
sea squirt
(Ciona savignyi)
 Ascidiacea CSA.5741 36
  • 22 (a)
 ManyToMany
Species with no ortholog for ADGRB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB2 Gene

ENSEMBL:
Gene Tree for ADGRB2 (if available)
TreeFam:
Gene Tree for ADGRB2 (if available)

Paralogs for ADGRB2 Gene

Paralogs for ADGRB2 Gene

genes like me logo Genes that share paralogs with ADGRB2: view

Variants for ADGRB2 Gene

Sequence variations from dbSNP and Humsavar for ADGRB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs909001 -- 31,731,046(+) CCCTC(A/C/G/T)GGCCG reference, synonymous-codon
rs1127100 -- 31,728,046(-) GGGGC(A/G)GCCGA intron-variant, reference, synonymous-codon
rs1043163 -- 31,727,366(+) TTTCA(A/C/G/T)ACTCC utr-variant-3-prime
rs1043171 -- 31,727,229(-) TGTTT(C/T)TCAGA utr-variant-3-prime
rs1043175 -- 31,727,225(+) TCTCA(A/C/G/T)AGGCC utr-variant-3-prime

Variation tolerance for ADGRB2 Gene

Residual Variation Intolerance Score: 5.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.68% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRB2 Gene

Disorders for ADGRB2 Gene

Relevant External Links for ADGRB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRB2

No disorders were found for ADGRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRB2 Gene

Publications for ADGRB2 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T. … Tokino T. (Cytogenet. Cell Genet. 1997) 2 3 4 23 67
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  3. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. (PMID: 16412436) Jeong B.C. … Kim K.K. (FEBS Lett. 2006) 3 23
  4. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. (PMID: 21787750) Zencir S. … Mohanty S. (Biochem. Biophys. Res. Commun. 2011) 3
  5. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. (PMID: 20367554) Okajima D. … Yokota H. (J. Recept. Signal Transduct. Res. 2010) 3

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