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Aliases for ADGRB2 Gene

Aliases for ADGRB2 Gene

  • Adhesion G Protein-Coupled Receptor B2 2 3 5
  • Brain-Specific Angiogenesis Inhibitor 2 2 3 4
  • BAI2 3 4

External Ids for ADGRB2 Gene

Previous HGNC Symbols for ADGRB2 Gene

  • BAI2

Summaries for ADGRB2 Gene

Entrez Gene Summary for ADGRB2 Gene

  • This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for ADGRB2 Gene

ADGRB2 (Adhesion G Protein-Coupled Receptor B2) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB3.

UniProtKB/Swiss-Prot for ADGRB2 Gene

  • Orphan receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT signaling pathway probably via a G-protein dependent pathway (PubMed:20367554). Might be involved in angiogenesis inhibition (By similarity).

Gene Wiki entry for ADGRB2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB2 Gene

Genomics for ADGRB2 Gene

Regulatory Elements for ADGRB2 Gene

Enhancers for ADGRB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G031711 2 FANTOM5 Ensembl ENCODE dbSUPER 32.6 +51.1 51087 4.8 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ADGRB2 ENSG00000224066 SNRNP40 DCDC2B TSSK3 IQCC PEF1 ENSG00000235790 KPNA6 EIF3I
GH01G031699 1.7 FANTOM5 ENCODE dbSUPER 20.7 +62.1 62114 6.7 FOXA2 MLX WRNIP1 ARID4B DMAP1 FOS DEK SP5 JUNB MXD4 ENSG00000235790 ADGRB2 PEF1 TINAGL1 LOC105378626 COL16A1 MTMR9LP GC01M031668
GH01G031780 1.6 Ensembl ENCODE dbSUPER 19.4 -17.4 -17380 2.9 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF2 CBX5 ZNF143 ZNF263 ADGRB2 COL16A1 GC01M031767 ENSG00000254545
GH01G031752 1.3 Ensembl ENCODE dbSUPER 22.1 +10.4 10432 3.4 ESRRA GTF2E2 CEBPG NFXL1 ZIC2 ZNF664 ZNF335 HIC1 CTBP1 GLIS2 ADGRB2 MIR4254 GC01P031741
GH01G032756 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.2 -995.3 -995276 6.8 HDGF PKNOX1 FOXA2 ARID4B SIN3A YY1 CBX5 FOS SP5 MXD4 FNDC5 S100PBP ENSG00000224409 ZBTB8B SYNC ADGRB2 KIAA1522 TMEM54
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRB2 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRB2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000251074 893 1201 HDGF HDAC1 RB1 ZSCAN4 ZNF2 ZNF121 ZNF366 REST ZEB2 ZNF398
ENSR00000251073 1993 201 RB1 ARNT SIN3A ZNF48 RAD21 GLIS2 ZNF366 ZNF143 RCOR1 ZNF391

Genomic Location for ADGRB2 Gene

Chromosome:
1
Start:
31,727,105 bp from pter
End:
31,764,893 bp from pter
Size:
37,789 bases
Orientation:
Minus strand

Genomic View for ADGRB2 Gene

Genes around ADGRB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB2 Gene

Proteins for ADGRB2 Gene

  • Protein details for ADGRB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60241-AGRB2_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor B2
    Protein Accession:
    O60241
    Secondary Accessions:
    • B9EGK9
    • Q5T6K0
    • Q8NGW8
    • Q96GZ9

    Protein attributes for ADGRB2 Gene

    Size:
    1585 amino acids
    Molecular mass:
    172656 Da
    Quaternary structure:
    • Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Interacts with GABPB2 (By similarity). Interacts (via carboxy-terminus) with TAX1BP3 (PubMed:21787750).
    SequenceCaution:
    • Sequence=BAA25362.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI16890.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRB2 Gene

Post-translational modifications for ADGRB2 Gene

  • Glycosylated.
  • Proteolytically cleaved at 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment.
  • Glycosylation at Asn106, Asn191, posLast=192192, Asn356, posLast=437437, Asn560, posLast=645645, and Asn867
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for ADGRB2
  • Santa Cruz Biotechnology (SCBT) Antibodies for ADGRB2

No data available for DME Specific Peptides for ADGRB2 Gene

Domains & Families for ADGRB2 Gene

Gene Families for ADGRB2 Gene

Graphical View of Domain Structure for InterPro Entry

O60241

UniProtKB/Swiss-Prot:

AGRB2_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRB2: view

Function for ADGRB2 Gene

Molecular function for ADGRB2 Gene

UniProtKB/Swiss-Prot EnzymeRegulation:
Displays increased activity following removal of N-terminal regions (mimicking the situation after proteolytic cleavage in the GPS domain and N-terminal fragment release).
UniProtKB/Swiss-Prot Function:
Orphan receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT signaling pathway probably via a G-protein dependent pathway (PubMed:20367554). Might be involved in angiogenesis inhibition (By similarity).

Gene Ontology (GO) - Molecular Function for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with ADGRB2: view
genes like me logo Genes that share phenotypes with ADGRB2: view

Animal Models for ADGRB2 Gene

MGI Knock Outs for ADGRB2:

Animal Model Products

miRNA for ADGRB2 Gene

miRTarBase miRNAs that target ADGRB2

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRB2 Gene

Localization for ADGRB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRB2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3

Gene Ontology (GO) - Cellular Components for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

Pathways & Interactions for ADGRB2 Gene

SuperPathways for ADGRB2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
GO:0007422 peripheral nervous system development IEA --
GO:0016525 negative regulation of angiogenesis IEA --
genes like me logo Genes that share ontologies with ADGRB2: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRB2 Gene

Transcripts for ADGRB2 Gene

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^
SP1: -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: - - - - - - - - - - - -
SP9: -
SP10: -
SP11:
SP12:
SP13: - -
SP14:
SP15:
SP16:

ExUns: 21 ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28a · 28b ^ 29 ^ 30 ^ 31a · 31b · 31c ^ 32 ^ 33 ^ 34a · 34b ^ 35a · 35b
SP1: - - - - - -
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5:
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:

Relevant External Links for ADGRB2 Gene

GeneLoc Exon Structure for
ADGRB2
ECgene alternative splicing isoforms for
ADGRB2

Expression for ADGRB2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRB2 Gene

This gene is overexpressed in Cerebrospinal fluid (57.4) and Vitreous humor (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB2 Gene



Protein tissue co-expression partners for ADGRB2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRB2 Gene:

ADGRB2

mRNA Expression by UniProt/SwissProt for ADGRB2 Gene:

O60241-AGRB2_HUMAN
Tissue specificity: Strongly expressed in brain. Also detected in heart, thymus, skeletal muscle, and different cell lines.

Evidence on tissue expression from TISSUES for ADGRB2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with ADGRB2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRB2 Gene

Orthologs for ADGRB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI2 34 35
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia BAI2 34 35
  • 92.77 (n)
cow
(Bos Taurus)
Mammalia BAI2 34 35
  • 92.14 (n)
rat
(Rattus norvegicus)
Mammalia Bai2 34
  • 90.65 (n)
mouse
(Mus musculus)
Mammalia Bai2 34 35
  • 89.95 (n)
Adgrb2 16
platypus
(Ornithorhynchus anatinus)
Mammalia BAI2 35
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves BAI2 34 35
  • 75.17 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bai2 34
  • 67.09 (n)
zebrafish
(Danio rerio)
Actinopterygii BAI2 35
  • 61 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta unc-5 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T21B6.3 35
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5741 35
  • 22 (a)
ManyToMany
Species where no ortholog for ADGRB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB2 Gene

ENSEMBL:
Gene Tree for ADGRB2 (if available)
TreeFam:
Gene Tree for ADGRB2 (if available)

Paralogs for ADGRB2 Gene

Paralogs for ADGRB2 Gene

genes like me logo Genes that share paralogs with ADGRB2: view

Variants for ADGRB2 Gene

Sequence variations from dbSNP and Humsavar for ADGRB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000245649 -- 31,730,894(+) TGGGT(A/G)TCGGC nc-transcript-variant, reference, missense
rs1000296450 -- 31,730,637(+) CAGAC(A/G)CCACG intron-variant, downstream-variant-500B
rs1000296809 -- 31,743,057(+) ACCAC(C/G/T)GGCGC intron-variant
rs1000351829 -- 31,731,497(+) GGGAG(G/T)TACCA intron-variant
rs1000491103 -- 31,761,209(+) GTCCG(C/G)CCACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRB2 Gene

Variant ID Type Subtype PubMed ID
esv2758930 CNV loss 17122850
nsv1007390 CNV gain 25217958
nsv1007786 CNV gain 25217958
nsv1121760 CNV deletion 24896259
nsv461028 CNV loss 19166990
nsv545953 CNV loss 21841781
nsv950385 CNV deletion 24416366

Variation tolerance for ADGRB2 Gene

Residual Variation Intolerance Score: 5.68% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.77; 66.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRB2 Gene

Disorders for ADGRB2 Gene

Relevant External Links for ADGRB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRB2

No disorders were found for ADGRB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRB2 Gene

Publications for ADGRB2 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T. … Tokino T. (Cytogenet. Cell Genet. 1997) 2 3 4 22 64
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 64
  3. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. (PMID: 21787750) Zencir S. … Mohanty S. (Biochem. Biophys. Res. Commun. 2011) 3 4 64
  4. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. (PMID: 20367554) Okajima D. … Yokota H. (J. Recept. Signal Transduct. Res. 2010) 3 4 64
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64

Products for ADGRB2 Gene

Sources for ADGRB2 Gene

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