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Aliases for ADGRB1 Gene

Aliases for ADGRB1 Gene

  • Adhesion G Protein-Coupled Receptor B1 2 3 5
  • Brain-Specific Angiogenesis Inhibitor 1 2 3
  • BAI1 3 4
  • GDAIF 3

External Ids for ADGRB1 Gene

Previous HGNC Symbols for ADGRB1 Gene

  • BAI1

Summaries for ADGRB1 Gene

Entrez Gene Summary for ADGRB1 Gene

  • Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRB1 Gene

ADGRB1 (Adhesion G Protein-Coupled Receptor B1) is a Protein Coding gene. Diseases associated with ADGRB1 include Glioblastoma. Among its related pathways are DNA damage response and p53 Pathway (RnD). GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRB3.

UniProtKB/Swiss-Prot for ADGRB1 Gene

  • Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.

Gene Wiki entry for ADGRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB1 Gene

Genomics for ADGRB1 Gene

Regulatory Elements for ADGRB1 Gene

Enhancers for ADGRB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F142382 1.2 Ensembl ENCODE 14.5 -66.3 -66346 2.2 MLX ZFP64 ARID4B SIN3A ZNF48 SLC30A9 ZNF143 SP5 NFYC MXD4 TSNARE1 ADGRB1 ZNF696 LOC100133669 GC08P142321
GH08F142234 1 Ensembl ENCODE 16.5 -214.0 -214033 2.0 CTCF TAF1 JUN MAX RAD21 ZIC2 RCOR1 FOSL2 FOS TCF7L2 ADGRB1 LOC100133669 GC08M142249 RN7SL260P LINC00051
GH08F142950 1.1 FANTOM5 ENCODE 11.7 +502.2 502192 3.0 TFAP4 CBX3 JUN TSC22D4 YBX1 RARA FOSL1 ZNF791 TRIM24 FOS ZNF623 ADGRB1 ENSG00000261710 LYNX1 LOC105375794 CDC42P3
GH08F142322 0.7 FANTOM5 13.4 -126.5 -126503 0.4 BCOR SMARCA5 ZBTB2 ARNT ZNF366 ZNF512 NBN PRDM1 ADGRB1 TSNARE1 GC08P142321
GH08F141567 0.8 ENCODE 11.6 -882.3 -882285 0.2 PKNOX1 ZNF792 ARID4B ZSCAN9 ZNF143 SOX5 KLF11 TFE3 HMG20B MIER1 MROH5 ADGRB1 GC08P141529 MIR1302-7
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRB1 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001906598 470 601

Genomic Location for ADGRB1 Gene

Chromosome:
8
Start:
142,449,430 bp from pter
End:
142,545,009 bp from pter
Size:
95,580 bases
Orientation:
Plus strand

Genomic View for ADGRB1 Gene

Genes around ADGRB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB1 Gene

Proteins for ADGRB1 Gene

  • Protein details for ADGRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14514-BAI1_HUMAN
    Recommended name:
    Brain-specific angiogenesis inhibitor 1
    Protein Accession:
    O14514

    Protein attributes for ADGRB1 Gene

    Size:
    1584 amino acids
    Molecular mass:
    173501 Da
    Quaternary structure:
    • Interacts with ELMO1 and DOCK1. When bound to ELMO1 and DOCK1, it may act as a module to promote the engulfment (By similarity). Interacts with MAGI1, MAGI3, BAIAP2 and PHYHIP.

neXtProt entry for ADGRB1 Gene

Post-translational modifications for ADGRB1 Gene

  • The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGRB1 Gene

Domains & Families for ADGRB1 Gene

Gene Families for ADGRB1 Gene

Suggested Antigen Peptide Sequences for ADGRB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O14514

UniProtKB/Swiss-Prot:

BAI1_HUMAN :
  • The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Domain:
  • The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF.
  • Contains 1 GPS domain.
  • Contains 5 TSP type-1 domains.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRB1: view

Function for ADGRB1 Gene

Molecular function for ADGRB1 Gene

UniProtKB/Swiss-Prot Function:
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Gene Ontology (GO) - Molecular Function for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,IDA 23782696
genes like me logo Genes that share ontologies with ADGRB1: view
genes like me logo Genes that share phenotypes with ADGRB1: view

Animal Models for ADGRB1 Gene

MGI Knock Outs for ADGRB1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRB1 Gene

Localization for ADGRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB1 Gene

Cell membrane; Multi-pass membrane protein. Note=Likely to be concentrated at cell-cell adhesion sites.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRB1 gene
Compartment Confidence
plasma membrane 5
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS 9647739
GO:0005887 integral component of plasma membrane TAS 9647739
GO:0005911 cell-cell junction TAS 9647739
GO:0014069 postsynaptic density IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRB1: view

Pathways & Interactions for ADGRB1 Gene

genes like me logo Genes that share pathways with ADGRB1: view

Pathways by source for ADGRB1 Gene

1 KEGG pathway for ADGRB1 Gene
1 R&D Systems pathway for ADGRB1 Gene
1 Qiagen pathway for ADGRB1 Gene

Gene Ontology (GO) - Biological Process for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction IEA,TAS 9647739
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007409 axonogenesis TAS 10343108
genes like me logo Genes that share ontologies with ADGRB1: view

No data available for SIGNOR curated interactions for ADGRB1 Gene

Drugs & Compounds for ADGRB1 Gene

(1) Drugs for ADGRB1 Gene - From: DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
PHOSPHATIDYLSERINE Pharma 0
genes like me logo Genes that share compounds with ADGRB1: view

Transcripts for ADGRB1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB1 Gene

No ASD Table

Relevant External Links for ADGRB1 Gene

GeneLoc Exon Structure for
ADGRB1
ECgene alternative splicing isoforms for
ADGRB1

Expression for ADGRB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADGRB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRB1 Gene

This gene is overexpressed in Fetal Brain (68.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGRB1 Gene



Protein tissue co-expression partners for ADGRB1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRB1 Gene:

ADGRB1

mRNA Expression by UniProt/SwissProt for ADGRB1 Gene:

O14514-BAI1_HUMAN
Tissue specificity: Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes.
genes like me logo Genes that share expression patterns with ADGRB1: view

Primer Products

No data available for mRNA differential expression in normal tissues for ADGRB1 Gene

Orthologs for ADGRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAI1 34 35
  • 91.1 (n)
dog
(Canis familiaris)
Mammalia BAI1 34 35
  • 90.51 (n)
mouse
(Mus musculus)
Mammalia Bai1 35 34
  • 88.33 (n)
OneToOne
Adgrb1 16
rat
(Rattus norvegicus)
Mammalia Bai1 34
  • 87.93 (n)
oppossum
(Monodelphis domestica)
Mammalia BAI1 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAI1 35
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves BAI1 34 35
  • 73.71 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 80 (a)
OneToMany
-- 35
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bai1 34
  • 69.48 (n)
zebrafish
(Danio rerio)
Actinopterygii bai1a 35
  • 70 (a)
OneToMany
BAI1 (1 of 3) 35
  • 61 (a)
OneToMany
bai1b 35
  • 59 (a)
OneToMany
Dr.15237 34
fruit fly
(Drosophila melanogaster)
Insecta unc-5 35
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C36B7.5 35
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
ManyToMany
Species where no ortholog for ADGRB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB1 Gene

ENSEMBL:
Gene Tree for ADGRB1 (if available)
TreeFam:
Gene Tree for ADGRB1 (if available)

Paralogs for ADGRB1 Gene

Paralogs for ADGRB1 Gene

genes like me logo Genes that share paralogs with ADGRB1: view

Variants for ADGRB1 Gene

Sequence variations from dbSNP and Humsavar for ADGRB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10090888 -- 142,458,298(+) AGGGT(A/G)TGATT intron-variant
rs10092230 -- 142,528,916(+) GCTGC(A/C/G)CTGCG intron-variant
rs10092420 -- 142,460,778(+) TTCCA(C/T)GCCTG intron-variant
rs10095825 -- 142,533,239(+) AGGGC(A/G)GGGTG intron-variant
rs10097101 -- 142,537,753(+) ACAGG(C/T)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRB1 Gene

Variant ID Type Subtype PubMed ID
dgv3924n106 CNV deletion 24896259
dgv4265e59 CNV duplication 20981092
dgv7334n100 CNV gain 25217958
dgv7335n100 CNV gain 25217958
esv1969642 CNV deletion 18987734
esv2202647 CNV deletion 18987734
esv2661137 CNV deletion 23128226
esv2668515 CNV deletion 23128226
esv2737889 CNV deletion 23290073
esv2737890 CNV deletion 23290073
esv2737891 CNV deletion 23290073
esv2737892 CNV deletion 23290073
esv2737893 CNV deletion 23290073
esv2737894 CNV deletion 23290073
esv2737896 CNV deletion 23290073
esv2737897 CNV deletion 23290073
esv2737898 CNV deletion 23290073
esv2737899 CNV deletion 23290073
esv2737900 CNV deletion 23290073
esv2737901 CNV deletion 23290073
esv2737902 CNV deletion 23290073
esv2737903 CNV deletion 23290073
esv2737904 CNV deletion 23290073
esv2737905 CNV deletion 23290073
esv2737907 CNV deletion 23290073
esv2737908 CNV deletion 23290073
esv2737909 CNV deletion 23290073
esv2740780 CNV deletion 23290073
esv2759650 CNV gain 17122850
esv3364070 CNV duplication 20981092
esv8650 CNV loss 19470904
esv8930 CNV loss 19470904
nsv1031969 CNV gain 25217958
nsv1075177 CNV deletion 25765185
nsv1076120 CNV deletion 25765185
nsv1110823 CNV insertion 24896259
nsv1125021 CNV duplication 24896259
nsv1128980 CNV duplication 24896259
nsv1137413 CNV deletion 24896259
nsv1149077 CNV insertion 26484159
nsv470245 CNV loss 18288195
nsv612707 CNV loss 21841781
nsv824755 CNV loss 20364138
nsv824756 CNV gain 20364138
nsv950002 CNV deletion 24416366

Variation tolerance for ADGRB1 Gene

Residual Variation Intolerance Score: 3.73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRB1 Gene

Disorders for ADGRB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRB1 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
glioblastoma
  • glioblastoma multiforme
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADGRB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRB1
genes like me logo Genes that share disorders with ADGRB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRB1 Gene

Publications for ADGRB1 Gene

  1. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (PMID: 12507886) Kaur B. … Van Meir E.G. (Am. J. Pathol. 2003) 3 4 22 64
  2. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PMID: 10343108) Oda K. … Tokino T. (Cytogenet. Cell Genet. 1999) 3 4 22 64
  3. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (PMID: 9647739) Shiratsuchi T. … Tokino T. (Biochem. Biophys. Res. Commun. 1998) 3 4 22 64
  4. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T. … Tokino T. (Cytogenet. Cell Genet. 1997) 2 3 22 64
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 64

Products for ADGRB1 Gene

Sources for ADGRB1 Gene

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