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Aliases for ADGRB1 Gene

Aliases for ADGRB1 Gene

  • Adhesion G Protein-Coupled Receptor B1 2 3
  • BAI1 3 4 6
  • Brain-Specific Angiogenesis Inhibitor 1 2 3
  • GDAIF 3

External Ids for ADGRB1 Gene

Previous HGNC Symbols for ADGRB1 Gene

  • BAI1

Summaries for ADGRB1 Gene

Entrez Gene Summary for ADGRB1 Gene

  • Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas [provided by RefSeq, Jul 2008]

GeneCards Summary for ADGRB1 Gene

ADGRB1 (Adhesion G Protein-Coupled Receptor B1) is a Protein Coding gene. Among its related pathways are p53 Signaling and p53 signaling pathway. An important paralog of this gene is UNC5D.

UniProtKB/Swiss-Prot for ADGRB1 Gene

  • Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.

Gene Wiki entry for ADGRB1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRB1 Gene

Genomics for ADGRB1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADGRB1 Gene

Start:
142,449,430 bp from pter
End:
142,545,009 bp from pter
Size:
95,580 bases
Orientation:
Plus strand

Genomic View for ADGRB1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGRB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRB1 Gene

No data available for Regulatory Elements for ADGRB1 Gene

Proteins for ADGRB1 Gene

  • Protein details for ADGRB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14514-BAI1_HUMAN
    Recommended name:
    Brain-specific angiogenesis inhibitor 1
    Protein Accession:
    O14514
    Secondary Accessions:

    Protein attributes for ADGRB1 Gene

    Size:
    1584 amino acids
    Molecular mass:
    173501 Da
    Quaternary structure:
    • Interacts with ELMO1 and DOCK1. When bound to ELMO1 and DOCK1, it may act as a module to promote the engulfment (By similarity). Interacts with MAGI1, MAGI3, BAIAP2 and PHYHIP.

neXtProt entry for ADGRB1 Gene

Proteomics data for ADGRB1 Gene at MOPED

Post-translational modifications for ADGRB1 Gene

  • The endogenous protein is proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRB1 Gene

Domains for ADGRB1 Gene

Gene Families for ADGRB1 Gene

HGNC:
  • GPCRBO :GPCR / Class B : Orphans

Graphical View of Domain Structure for InterPro Entry

O14514

UniProtKB/Swiss-Prot:

BAI1_HUMAN :
  • O14514
Domain:
  • The TSP1 repeats inhibit in vivo angiogenesis in rat cornea induced by BFGF
  • Contains 1 GPS domain.
  • Contains 5 TSP type-1 domains.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with ADGRB1: view

No data available for Suggested Antigen Peptide Sequences for ADGRB1 Gene

Function for ADGRB1 Gene

Molecular function for ADGRB1 Gene

UniProtKB/Swiss-Prot Function: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Likely to be a potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53 signal in suppression of glioblastoma. May function in cell adhesion and signal transduction in the brain.
UniProtKB/Swiss-Prot Induction: By p53/TP53

Gene Ontology (GO) - Molecular Function for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ADGRB1: view

Phenotypes for ADGRB1 Gene

GenomeRNAi human phenotypes for ADGRB1:
genes like me logo Genes that share phenotypes with ADGRB1: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRB1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADGRB1 Gene

Localization for ADGRB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRB1 Gene

Cell membrane; Multi-pass membrane protein. Note=Likely to be concentrated at cell-cell adhesion sites.

Gene Ontology (GO) - Cellular Components for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS 10343108
GO:0005887 integral component of plasma membrane TAS 9647739
GO:0005911 cell-cell junction TAS 9647739
GO:0016020 membrane --
GO:0016021 integral component of membrane TAS 15203201
genes like me logo Genes that share ontologies with ADGRB1: view

No data available for Subcellular locations from COMPARTMENTS for ADGRB1 Gene

Pathways for ADGRB1 Gene

SuperPathways for ADGRB1 Gene

Superpath Contained pathways
1 p53 Signaling
2 p53 signaling pathway
genes like me logo Genes that share pathways with ADGRB1: view

Pathways by source for ADGRB1 Gene

1 Qiagen pathway for ADGRB1 Gene
1 KEGG pathway for ADGRB1 Gene

Gene Ontology (GO) - Biological Process for ADGRB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 9647739
GO:0007166 cell surface receptor signaling pathway --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007218 neuropeptide signaling pathway --
genes like me logo Genes that share ontologies with ADGRB1: view

Transcripts for ADGRB1 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRB1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADGRB1
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRB1 Gene

No ASD Table

Relevant External Links for ADGRB1 Gene

GeneLoc Exon Structure for
ADGRB1
ECgene alternative splicing isoforms for
ADGRB1

Expression for ADGRB1 Gene

mRNA expression in normal human tissues for ADGRB1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGRB1 Gene

mRNA Expression by UniProt/SwissProt for ADGRB1 Gene

O14514-BAI1_HUMAN
Tissue specificity: Specifically expressed in brain. Reduced or no expression is observed in some glioblastoma cell lines and cancer tissues. No expression in astrocytes.
genes like me logo Genes that share expressions with ADGRB1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ADGRB1 Gene

Orthologs for ADGRB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia BAI1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia BAI1 35
  • 91.1 (n)
  • 94.23 (a)
BAI1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia BAI1 35
  • 90.51 (n)
  • 93.56 (a)
BAI1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Bai1 35
  • 88.33 (n)
  • 94.18 (a)
Bai1 16
Bai1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia BAI1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia BAI1 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Bai1 35
  • 87.93 (n)
  • 94.29 (a)
chicken
(Gallus gallus)
Aves BAI1 35
  • 73.71 (n)
  • 78.66 (a)
BAI1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 72 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia bai1 35
  • 69.48 (n)
  • 74.3 (a)
zebrafish
(Danio rerio)
Actinopterygii BAI1 (1 of 3) 36
  • 61 (a)
OneToMany
bai1a 36
  • 70 (a)
OneToMany
bai1b 36
  • 59 (a)
OneToMany
Dr.15237 35
fruit fly
(Drosophila melanogaster)
Insecta unc-5 36
  • 15 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C36B7.5 36
  • 16 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
ManyToMany
Species with no ortholog for ADGRB1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADGRB1 Gene

ENSEMBL:
Gene Tree for ADGRB1 (if available)
TreeFam:
Gene Tree for ADGRB1 (if available)

Paralogs for ADGRB1 Gene

Paralogs for ADGRB1 Gene

genes like me logo Genes that share paralogs with ADGRB1: view

Variants for ADGRB1 Gene

Sequence variations from dbSNP and Humsavar for ADGRB1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs4074758 -- 142,485,368(-) GGGAA(A/C)GTTTG intron-variant
rs4074759 -- 142,485,143(-) CCAGG(C/T)CCCTC intron-variant
rs4077116 -- 142,492,850(+) TGGGT(A/C)TCTCA intron-variant
rs4394435 -- 142,534,163(-) GGGAC(C/T)GCACC intron-variant
rs4394436 -- 142,534,141(-) TTCCC(C/T)GCCTA intron-variant

Relevant External Links for ADGRB1 Gene

HapMap Linkage Disequilibrium report
ADGRB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADGRB1 Gene

Disorders for ADGRB1 Gene

(6) Novoseek inferred disease relationships for ADGRB1 Gene

Disease -log(P) Hits PubMed IDs
glioblastoma 63.2 8
tumors 19.9 3
gastric cancer 19.8 2
colorectal cancer 11.8 5
metastasis 3.44 3
genes like me logo Genes that share disorders with ADGRB1: view

No data available for UniProtKB/Swiss-Prot for ADGRB1 Gene

Publications for ADGRB1 Gene

  1. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). (PMID: 9533023) Shiratsuchi T. … Tokino T. (Cytogenet. Cell Genet. 1997) 2 3 23
  2. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. (PMID: 9647739) Shiratsuchi T. … Tokino T. (Biochem. Biophys. Res. Commun. 1998) 3 4 23
  3. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. (PMID: 10343108) Oda K. … Tokino T. (Cytogenet. Cell Genet. 1999) 3 4 23
  4. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. (PMID: 12507886) Kaur B. … Van Meir E.G. (Am. J. Pathol. 2003) 3 4 23
  5. Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. (PMID: 14980512) Koh J.T. … Kim K.K. (Exp. Cell Res. 2004) 3 23

Products for ADGRB1 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ADGRB1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ADGRB1
    • Block miRNA regulation of ADGRB1 using miScript Target Protectors

    Sources for ADGRB1 Gene

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