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ADGRA3 Gene(Protein Coding)

Adhesion G Protein-Coupled Receptor A3

GCID:
GC04M022345
GIFtS:
45
Genes Participants
UDN Logo

Aliases for ADGRA3 Gene

Aliases for ADGRA3 Gene

  • Adhesion G Protein-Coupled Receptor A3 2 3 5
  • G Protein-Coupled Receptor 125 2 3
  • G-Protein Coupled Receptor 125 3 4
  • GPR125 3 4
  • Probable G-Protein Coupled Receptor 125 3
  • PGR21 3
  • TEM5L 3

External Ids for ADGRA3 Gene

Previous HGNC Symbols for ADGRA3 Gene

  • GPR125

Summaries for ADGRA3 Gene

Entrez Gene Summary for ADGRA3 Gene

  • This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]

GeneCards Summary for ADGRA3 Gene

ADGRA3 (Adhesion G Protein-Coupled Receptor A3) is a Protein Coding gene. Diseases associated with ADGRA3 include Schizophrenia. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRA1.

UniProtKB/Swiss-Prot for ADGRA3 Gene

  • Orphan receptor that may have a role in planar cell polarity pathway.

Gene Wiki entry for ADGRA3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRA3 Gene

Genomics for ADGRA3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ADGRA3 Gene

Enhancers for ADGRA3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRA3 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADGRA3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRA3 Gene

Chromosome:
4
Start:
22,345,071 bp from pter
End:
22,516,058 bp from pter
Size:
170,988 bases
Orientation:
Minus strand

Genomic View for ADGRA3 Gene

Genes around ADGRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRA3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGRA3 Gene

Proteins for ADGRA3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADGRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWK6-AGRA3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor A3
    Protein Accession:
    Q8IWK6
    Secondary Accessions:
    • Q6UXK9
    • Q86SQ5
    • Q8TC55

    Protein attributes for ADGRA3 Gene

    Size:
    1321 amino acids
    Molecular mass:
    146151 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with DLG1.
    Miscellaneous:
    • Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.
    SequenceCaution:
    • Sequence=AAH35645.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRA3 Gene

Proteomics data for ADGRA3 Gene at MOPED

Protein Expression for ADGRA3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADGRA3 Gene

  • Glycosylation at Asn 81, Asn 98, Asn 159, Asn 206, Asn 301, Asn 332, Asn 433, Asn 453, Asn 592, Asn 652, Asn 687, Asn 728, and Asn 821
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRA3 Gene

Domains & Families for ADGRA3 Gene

Gene Families for ADGRA3 Gene

HGNC:

Protein Domains for ADGRA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWK6

UniProtKB/Swiss-Prot:

AGRA3_HUMAN :
  • Contains 1 GPS domain.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Contains 5 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 GPS domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Similarity:
  • Contains 5 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ADGRA3: view

Function for ADGRA3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ADGRA3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that may have a role in planar cell polarity pathway.

Gene Ontology (GO) - Molecular Function for ADGRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 15021905
genes like me logo Genes that share ontologies with ADGRA3: view

Phenotypes for ADGRA3 Gene

MGI mutant phenotypes for ADGRA3:
inferred from 1 alleles
GenomeRNAi human phenotypes for ADGRA3:
genes like me logo Genes that share phenotypes with ADGRA3: view

Animal Models for ADGRA3 Gene

MGI Knock Outs for ADGRA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRA3

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRA3 Gene

Localization for ADGRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRA3 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for ADGRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRA3: view

No data available for Subcellular locations from COMPARTMENTS for ADGRA3 Gene

Pathways & Interactions for ADGRA3 Gene

SuperPathways for ADGRA3 Gene

PathCards logoMore details on SuperPathways for ADGRA3
No Data Available

Gene Ontology (GO) - Biological Process for ADGRA3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADGRA3 Gene

Drugs & Compounds for ADGRA3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ADGRA3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ADGRA3 Gene

(4) REFSEQ mRNAs :
(241) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRA3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP8:
SP9:

ExUns: 21 ^ 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ADGRA3 Gene

GeneLoc Exon Structure for
ADGRA3
ECgene alternative splicing isoforms for
ADGRA3

Expression for ADGRA3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for ADGRA3 Gene

mRNA expression in normal human tissues for ADGRA3 Gene
mRNA expression by GTEx for ADGRA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRA3 Gene

This gene is overexpressed in Bone (34.6), Colon muscle (22.5), and Pancreatic juice (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRA3 Gene



genes like me logo Genes that share expression patterns with ADGRA3: view

Protein tissue co-expression partners for ADGRA3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADGRA3 Gene

Orthologs for ADGRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRA3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia GPR125 35
  • 90.28 (n)
  • 96.11 (a)
GPR125 36
  • 96 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia GPR125 35
  • 83.48 (n)
  • 88.81 (a)
GPR125 36
  • 89 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gpr125 35
  • 85.72 (n)
  • 93.67 (a)
Adgra3 16
Gpr125 36
  • 93 (a)
 OneToOne
chimpanzee
(Pan troglodytes)
 Mammalia GPR125 35
  • 99.27 (n)
  • 99.02 (a)
GPR125 36
  • 98 (a)
 OneToOne
rat
(Rattus norvegicus)
 Mammalia Gpr125 35
  • 85.2 (n)
  • 91.92 (a)
oppossum
(Monodelphis domestica)
 Mammalia GPR125 36
  • 86 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 89 (a)
 OneToMany
-- 36
  • 91 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves GPR125 35
  • 79.78 (n)
  • 87.28 (a)
GPR125 36
  • 84 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia GPR125 36
  • 78 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gpr125 35
  • 73.51 (n)
  • 80.41 (a)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.24458 35
zebrafish
(Danio rerio)
 Actinopterygii Dr.14009 35
LOC100003592 35
  • 63.05 (n)
  • 67.18 (a)
GPR125 36
  • 59 (a)
 OneToOne
fruit fly
(Drosophila melanogaster)
 Insecta CG15744 36
  • 14 (a)
 OneToMany
Species with no ortholog for ADGRA3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRA3 Gene

ENSEMBL:
Gene Tree for ADGRA3 (if available)
TreeFam:
Gene Tree for ADGRA3 (if available)

Paralogs for ADGRA3 Gene

Paralogs for ADGRA3 Gene

Pseudogenes.org Pseudogenes for ADGRA3 Gene

genes like me logo Genes that share paralogs with ADGRA3: view

Variants for ADGRA3 Gene

Sequence variations from dbSNP and Humsavar for ADGRA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs9002 - 22,388,544(-) TCTTC(A/G)TGGTC reference, missense
rs3814416 - 22,388,174(-) AAATG(G/T)GCACT reference, missense
rs8948 -- 22,387,688(-) TTCCT(A/G)GGCAG utr-variant-3-prime
rs12700 -- 22,388,551(-) AGTGC(A/G)TTCTT reference, synonymous-codon
rs716411 -- 22,425,575(-) CTGAT(C/G)CTACC intron-variant

Variation tolerance for ADGRA3 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.36% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRA3 Gene

Disorders for ADGRA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADGRA3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADGRA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRA3
genes like me logo Genes that share disorders with ADGRA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRA3 Gene

Publications for ADGRA3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 67
  2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 2 3
  3. Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors. (PMID: 24902969) Sachs C. … Seandel M. (Andrology 2014) 3
  4. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/I^-catenin signaling. (PMID: 21875946) Berndt J.D. … Moon R.T. (J. Cell Biol. 2011) 3
  5. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3

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