Free for academic non-profit institutions. Other users need a Commercial license

ADGRA3 Gene(Protein Coding)

Adhesion G Protein-Coupled Receptor A3

GCID:
GC04M022345
GIFtS:
45
Genes Participants
UDN Logo

Aliases for ADGRA3 Gene

Aliases for ADGRA3 Gene

  • Adhesion G Protein-Coupled Receptor A3 2 3 5
  • G-Protein Coupled Receptor 125 3 4
  • GPR125 3 4
  • Probable G-Protein Coupled Receptor 125 3
  • G Protein-Coupled Receptor 125 2
  • PGR21 3
  • TEM5L 3

External Ids for ADGRA3 Gene

Previous HGNC Symbols for ADGRA3 Gene

  • GPR125

Summaries for ADGRA3 Gene

Entrez Gene Summary for ADGRA3 Gene

  • This gene encodes a member of the G protein-coupled receptor superfamily. This membrane protein may play a role in tumor angiogenesis through its interaction with the human homolog of the Drosophila disc large tumor suppressor gene. This gene is mapped to a candidate region of chromosome 4 which may be associated with bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2012]

GeneCards Summary for ADGRA3 Gene

ADGRA3 (Adhesion G Protein-Coupled Receptor A3) is a Protein Coding gene. Diseases associated with ADGRA3 include Schizophrenia and Retinitis Pigmentosa. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRA2.

UniProtKB/Swiss-Prot for ADGRA3 Gene

  • Orphan receptor that may have a role in planar cell polarity pathway.

Gene Wiki entry for ADGRA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRA3 Gene

Genomics for ADGRA3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for ADGRA3 Gene

Enhancers for ADGRA3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G022482 1.4 Ensembl ENCODE dbSUPER 20.1 +31.7 31690 4.3 PKNOX1 WRNIP1 BMI1 ZNF121 RELB IKZF2 CEBPB ZEB2 TBX21 PPARG ADGRA3 PIR53421 GC04P022366
GH04G022471 1.4 Ensembl ENCODE dbSUPER 18.4 +42.3 42328 5.3 ATF1 FOXA2 MLX EGR1 FOS CEBPB TBX21 KAT8 NFIL3 MIER3 ADGRA3 PIR53421 GC04P022366
GH04G022487 0.7 ENCODE 19.8 +28.1 28122 1.3 SOX5 SOX13 PKNOX1 TFAP4 ZNF384 PPARG ZIC2 ZBTB40 NCOR1 PBX2 ADGRA3 PIR53421 GC04P022366
GH04G022489 0.7 ENCODE 19.4 +25.2 25245 1.9 ZNF680 ZNF133 ZNF644 ZNF48 ZBTB40 ZNF121 PRDM6 ZGPAT SCRT2 BCL6 ADGRA3 PIR53421 GC04P022366
GH04G022499 1.3 Ensembl ENCODE dbSUPER 9.3 +14.5 14540 4.9 HDGF TBP PKNOX1 FEZF1 BMI1 YBX1 ZBTB40 GATA2 FOS RELB ADGRA3 PIR53421 GC04P022366
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRA3 on UCSC Golden Path with GeneCards custom track

Promoters for ADGRA3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000166667 558 2600 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 ZNF121 GLIS2

Genomic Location for ADGRA3 Gene

Chromosome:
4
Start:
22,345,071 bp from pter
End:
22,516,058 bp from pter
Size:
170,988 bases
Orientation:
Minus strand

Genomic View for ADGRA3 Gene

Genes around ADGRA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRA3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGRA3 Gene

Proteins for ADGRA3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADGRA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWK6-AGRA3_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor A3
    Protein Accession:
    Q8IWK6
    Secondary Accessions:
    • Q6UXK9
    • Q86SQ5
    • Q8TC55

    Protein attributes for ADGRA3 Gene

    Size:
    1321 amino acids
    Molecular mass:
    146151 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with DLG1.
    Miscellaneous:
    • Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.
    SequenceCaution:
    • Sequence=AAH35645.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRA3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRA3 Gene

Protein Expression for ADGRA3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADGRA3 Gene

  • Glycosylation at posLast=8181, Asn98, Asn159, Asn206, Asn301, posLast=332332, posLast=433433, Asn453, Asn592, Asn652, Asn687, Asn728, and Asn821
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRA3 Gene

Domains & Families for ADGRA3 Gene

Gene Families for ADGRA3 Gene

HGNC:

Protein Domains for ADGRA3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGRA3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWK6

UniProtKB/Swiss-Prot:

AGRA3_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRA3: view

Function for ADGRA3 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for ADGRA3 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor that may have a role in planar cell polarity pathway.

Gene Ontology (GO) - Molecular Function for ADGRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,IEA --
genes like me logo Genes that share ontologies with ADGRA3: view

Phenotypes for ADGRA3 Gene

MGI mutant phenotypes for ADGRA3:
inferred from 1 alleles
GenomeRNAi human phenotypes for ADGRA3:
genes like me logo Genes that share phenotypes with ADGRA3: view

Animal Models for ADGRA3 Gene

MGI Knock Outs for ADGRA3:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRA3

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADGRA3 Gene

Localization for ADGRA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRA3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRA3 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for ADGRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009897 external side of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with ADGRA3: view

Pathways & Interactions for ADGRA3 Gene

SuperPathways for ADGRA3 Gene

PathCards logo More details on SuperPathways for ADGRA3
No Data Available

Gene Ontology (GO) - Biological Process for ADGRA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
genes like me logo Genes that share ontologies with ADGRA3: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRA3 Gene

Drugs & Compounds for ADGRA3 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ADGRA3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ADGRA3 Gene

(4) REFSEQ mRNAs :
(241) Selected AceView cDNA sequences:
(13) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRA3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: - -
SP8:
SP9:

ExUns: 21 ^ 22a · 22b · 22c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for ADGRA3 Gene

GeneLoc Exon Structure for
ADGRA3
ECgene alternative splicing isoforms for
ADGRA3

Expression for ADGRA3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRA3 Gene

mRNA expression in normal human tissues for ADGRA3 Gene
mRNA expression by GTEx for ADGRA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRA3 Gene

This gene is overexpressed in Bone (34.6), Colon muscle (22.5), and Pancreatic juice (11.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRA3 Gene



Protein tissue co-expression partners for ADGRA3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRA3 Gene:

ADGRA3

Evidence on tissue expression from TISSUES for ADGRA3 Gene

  • Liver(4.4)
  • Eye(4.1)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with ADGRA3: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRA3 Gene

Orthologs for ADGRA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia GPR125 34 35
  • 99.27 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 91 (a)
 OneToMany
-- 35
  • 89 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia GPR125 34 35
  • 90.28 (n)
oppossum
(Monodelphis domestica)
 Mammalia GPR125 35
  • 86 (a)
 OneToOne
mouse
(Mus musculus)
 Mammalia Gpr125 34 35
  • 85.72 (n)
Adgra3 16
rat
(Rattus norvegicus)
 Mammalia Gpr125 34
  • 85.2 (n)
dog
(Canis familiaris)
 Mammalia GPR125 34 35
  • 83.48 (n)
chicken
(Gallus gallus)
 Aves GPR125 34 35
  • 79.78 (n)
lizard
(Anolis carolinensis)
 Reptilia GPR125 35
  • 78 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia gpr125 34
  • 73.51 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.24458 34
zebrafish
(Danio rerio)
 Actinopterygii LOC100003592 34
  • 63.05 (n)
GPR125 35
  • 59 (a)
 OneToOne
Dr.14009 34
fruit fly
(Drosophila melanogaster)
 Insecta CG15744 35
  • 14 (a)
 OneToMany
Species where no ortholog for ADGRA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRA3 Gene

ENSEMBL:
Gene Tree for ADGRA3 (if available)
TreeFam:
Gene Tree for ADGRA3 (if available)

Paralogs for ADGRA3 Gene

Paralogs for ADGRA3 Gene

Pseudogenes.org Pseudogenes for ADGRA3 Gene

genes like me logo Genes that share paralogs with ADGRA3: view

Variants for ADGRA3 Gene

Sequence variations from dbSNP and Humsavar for ADGRA3 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000012974 -- 22,499,825(+) TCCTT(C/T)AACAG intron-variant
rs1000034757 -- 22,436,221(+) CAAAG(A/G)CACAA intron-variant
rs1000053852 -- 22,477,762(+) AACCT(A/T)AAAAA intron-variant, upstream-variant-2KB
rs1000057320 -- 22,419,455(+) TAGTG(C/T)AATGT intron-variant
rs1000071093 -- 22,413,754(+) TTCTC(C/T)TTTTT nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADGRA3 Gene

Variant ID Type Subtype PubMed ID
esv1778171 CNV deletion 17803354
esv2656779 CNV deletion 23128226
esv2656963 CNV deletion 23128226
esv2667379 CNV deletion 23128226
esv2727288 CNV deletion 23290073
esv2727289 CNV deletion 23290073
esv2727290 CNV deletion 23290073
esv2741412 CNV deletion 23290073
esv3048040 CNV deletion 24192839
esv3310028 CNV mobile element insertion 20981092
esv3398780 CNV insertion 20981092
esv3563539 CNV deletion 23714750
esv3599899 CNV loss 21293372
esv3599900 CNV loss 21293372
esv3599902 CNV loss 21293372
esv3599904 CNV loss 21293372
esv5125 CNV loss 18987735
nsv1074699 CNV deletion 25765185
nsv1136824 CNV deletion 24896259
nsv1145971 CNV deletion 26484159
nsv289612 CNV deletion 16902084
nsv509881 OTHER sequence alteration 20534489
nsv510889 OTHER complex 20534489
nsv821634 CNV loss 15273396
nsv958228 CNV deletion 24416366

Variation tolerance for ADGRA3 Gene

Residual Variation Intolerance Score: 89.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.91; 74.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRA3 Gene

Human Gene Mutation Database (HGMD)
ADGRA3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRA3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRA3 Gene

Disorders for ADGRA3 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ADGRA3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
retinitis pigmentosa
  • retinitis pigmentosa 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADGRA3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRA3
genes like me logo Genes that share disorders with ADGRA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADGRA3 Gene

Publications for ADGRA3 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 64
  2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein. (PMID: 15021905) Yamamoto Y. … Takai Y. (Oncogene 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for ADGRA3 Gene

Sources for ADGRA3 Gene

Content
Loading form....