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Aliases for ADGRA2 Gene

Aliases for ADGRA2 Gene

  • Adhesion G Protein-Coupled Receptor A2 2 3 5
  • Tumor Endothelial Marker 5 2 3 4
  • G-Protein Coupled Receptor 124 3 4
  • GPR124 3 4
  • TEM5 3 4
  • G Protein-Coupled Receptor 124 2
  • KIAA1531 4

External Ids for ADGRA2 Gene

Previous HGNC Symbols for ADGRA2 Gene

  • GPR124

Summaries for ADGRA2 Gene

GeneCards Summary for ADGRA2 Gene

ADGRA2 (Adhesion G Protein-Coupled Receptor A2) is a Protein Coding gene. Among its related pathways are Integrins in angiogenesis. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRA3.

UniProtKB/Swiss-Prot for ADGRA2 Gene

  • Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).

Gene Wiki entry for ADGRA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRA2 Gene

Genomics for ADGRA2 Gene

Regulatory Elements for ADGRA2 Gene

Enhancers for ADGRA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F037813 1 Ensembl ENCODE 22.5 +30.4 30371 3.1 ATF1 PKNOX1 ARNT CREB3L1 FEZF1 ZNF121 ZNF766 GATA2 JUNB NCOA1 ADGRA2 ENSG00000255201 RAB11FIP1 GOT1L1 RPS20P22 GC08P037815 GC08M037706
GH08F037840 1.1 Ensembl ENCODE 12.1 +58.7 58694 4.0 ARID4B GLI4 FEZF1 DMAP1 ZNF2 ZNF48 ZNF121 GLIS2 ZNF302 KLF7 ENSG00000255201 RPS20P22 ENSG00000254306 ADGRA2 LOC102723716 RAB11FIP1 GOT1L1 RNU6-323P BRF2 GC08P037836
GH08F037761 0.8 ENCODE 11.4 -21.3 -21269 2.1 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000255201 BRF2 LOC100507403 ADGRA2 LOC102723701 ERLIN2 ENSG00000254290 RAB11FIP1 PROSC
GH08F037862 0.6 ENCODE 11.2 +79.5 79453 3.0 HDAC1 ATF1 KLF17 ZNF366 GATA2 CREM ZBTB11 CEBPB HDAC8 TFDP1 RAB11FIP1 ADGRA2 EIF4EBP1 GOT1L1 RNU6-323P ENSG00000280064
GH08F037866 0.6 ENCODE 11.2 +82.4 82367 0.2 RAB11FIP1 ADGRA2 EIF4EBP1 GOT1L1 ENSG00000280064
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADGRA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRA2 Gene

Chromosome:
8
Start:
37,784,191 bp from pter
End:
37,844,896 bp from pter
Size:
60,706 bases
Orientation:
Plus strand

Genomic View for ADGRA2 Gene

Genes around ADGRA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRA2 Gene

Proteins for ADGRA2 Gene

  • Protein details for ADGRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PE1-AGRA2_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor A2
    Protein Accession:
    Q96PE1
    Secondary Accessions:
    • A6H8W3
    • D3DSW4
    • Q8N3R1
    • Q8TEM3
    • Q96KB2
    • Q9P1Z7
    • Q9UFY4

    Protein attributes for ADGRA2 Gene

    Size:
    1338 amino acids
    Molecular mass:
    142647 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with DLG1 (via PDZ domains) (PubMed:15021905). The cleaved extracellular subunit interacts with the integrin heterodimer ITGAV:ITGB3 (PubMed:16982628).
    SequenceCaution:
    • Sequence=AAI46775.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL11992.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO27354.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA96055.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRA2 Gene

Post-translational modifications for ADGRA2 Gene

  • Glycosylated.
  • Proteolytically cleaved into two subunits, an extracellular subunit and a seven-transmembrane subunit (PubMed:22013897, PubMed:16982628). Cleaved by thrombin (F2) and MMP1 (PubMed:22013897). Also cleaved by MMP9, with lower efficiency (PubMed:22013897, PubMed:16982628). Presence of the protein disulfide-isomerase P4HB at the cell surface is additionally required for shedding of the extracellular subunit, suggesting that the subunits are linked by disulfide bonds (PubMed:22013897). Shedding is enhanced by the growth factor FGF2 and may promote cell survival during angiogenesis (PubMed:16982628).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRA2 Gene

No data available for DME Specific Peptides for ADGRA2 Gene

Domains & Families for ADGRA2 Gene

Suggested Antigen Peptide Sequences for ADGRA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PE1

UniProtKB/Swiss-Prot:

AGRA2_HUMAN :
  • The leucine-rich repeats (LRRs) are important for potentiation of WNT7 signaling.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • The leucine-rich repeats (LRRs) are important for potentiation of WNT7 signaling.
  • The RGD motif is involved in integrin ITGAV:ITGB3 binding.
  • Contains 1 GPS domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ADGRA2: view

Function for ADGRA2 Gene

Molecular function for ADGRA2 Gene

UniProtKB/Swiss-Prot Function:
Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).

Gene Ontology (GO) - Molecular Function for ADGRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity IEA,TAS --
GO:0005515 protein binding IPI 15021905
genes like me logo Genes that share ontologies with ADGRA2: view
genes like me logo Genes that share phenotypes with ADGRA2: view

Animal Models for ADGRA2 Gene

MGI Knock Outs for ADGRA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRA2

miRNA for ADGRA2 Gene

miRTarBase miRNAs that target ADGRA2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRA2 Gene

Localization for ADGRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRA2 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, filopodium. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact. {ECO:0000269 PubMed:21421844}.

Gene Ontology (GO) - Cellular Components for ADGRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0009986 cell surface IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,TAS --
GO:0030175 filopodium IEA --
genes like me logo Genes that share ontologies with ADGRA2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRA2 Gene

Pathways & Interactions for ADGRA2 Gene

SuperPathways for ADGRA2 Gene

SuperPathway Contained pathways
1 Integrins in angiogenesis
genes like me logo Genes that share pathways with ADGRA2: view

Pathways by source for ADGRA2 Gene

1 BioSystems pathway for ADGRA2 Gene

Gene Ontology (GO) - Biological Process for ADGRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002040 sprouting angiogenesis IEA,ISS --
GO:0007165 signal transduction IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS --
GO:0007417 central nervous system development IEA,ISS --
genes like me logo Genes that share ontologies with ADGRA2: view

No data available for SIGNOR curated interactions for ADGRA2 Gene

Transcripts for ADGRA2 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRA2 Gene

No ASD Table

Relevant External Links for ADGRA2 Gene

GeneLoc Exon Structure for
ADGRA2
ECgene alternative splicing isoforms for
ADGRA2

Expression for ADGRA2 Gene

mRNA expression in normal human tissues for ADGRA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRA2 Gene

This gene is overexpressed in Placenta (13.2), Fetal gut (8.6), Heart (8.0), Fetal testis (6.9), and Prostate (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRA2 Gene



Protein tissue co-expression partners for ADGRA2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADGRA2 Gene:

ADGRA2

mRNA Expression by UniProt/SwissProt for ADGRA2 Gene:

Q96PE1-AGRA2_HUMAN
Tissue specificity: Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).
genes like me logo Genes that share expression patterns with ADGRA2: view

Primer Products

No data available for mRNA differential expression in normal tissues for ADGRA2 Gene

Orthologs for ADGRA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GPR124 34 35
  • 99.45 (n)
dog
(Canis familiaris)
Mammalia GPR124 34 35
  • 88.97 (n)
mouse
(Mus musculus)
Mammalia Gpr124 34 35
  • 84.4 (n)
Adgra2 16
rat
(Rattus norvegicus)
Mammalia LOC100363275 34
  • 84.16 (n)
oppossum
(Monodelphis domestica)
Mammalia GPR124 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR124 35
  • 66 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GPR124 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR124 34 35
  • 72.58 (n)
lizard
(Anolis carolinensis)
Reptilia GPR124 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr124 34
  • 61.76 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69043 34
zebrafish
(Danio rerio)
Actinopterygii gpr124 34 35
  • 60.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG15744 35
  • 15 (a)
OneToMany
Species where no ortholog for ADGRA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRA2 Gene

ENSEMBL:
Gene Tree for ADGRA2 (if available)
TreeFam:
Gene Tree for ADGRA2 (if available)

Paralogs for ADGRA2 Gene

Paralogs for ADGRA2 Gene

genes like me logo Genes that share paralogs with ADGRA2: view

Variants for ADGRA2 Gene

Sequence variations from dbSNP and Humsavar for ADGRA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10088182 -- 37,808,414(+) GAGGG(C/T)CGAGG intron-variant
rs10089977 -- 37,811,836(+) ggtag(C/T)ttaca intron-variant
rs10095151 -- 37,838,717(+) TTCAG(C/G)CTGAG intron-variant
rs10101560 -- 37,835,784(+) CTGAA(C/T)TCCCC intron-variant
rs10101768 -- 37,836,097(+) CACAC(A/C)CCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRA2 Gene

Variant ID Type Subtype PubMed ID
nsv397948 CNV deletion 16902084
nsv509261 CNV insertion 20534489
nsv528524 CNV loss 19592680
nsv528598 CNV loss 19592680
nsv951126 CNV deletion 24416366

Variation tolerance for ADGRA2 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRA2 Gene

Disorders for ADGRA2 Gene

Relevant External Links for ADGRA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRA2

No disorders were found for ADGRA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRA2 Gene

Publications for ADGRA2 Gene

  1. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 64
  2. Cell surface tumor endothelial markers are conserved in mice and humans. (PMID: 11559528) Carson-Walter E.B. … St Croix B. (Cancer Res. 2001) 2 3 4 64
  3. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 64
  4. Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase. (PMID: 22013897) Vallon M. … Essler M. (Biochem. J. 2012) 3 4 64
  5. Proteolytically processed soluble tumor endothelial marker (TEM) 5 mediates endothelial cell survival during angiogenesis by linking integrin alpha(v)beta3 to glycosaminoglycans. (PMID: 16982628) Vallon M. … Essler M. (J. Biol. Chem. 2006) 3 4 64

Products for ADGRA2 Gene

Sources for ADGRA2 Gene

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