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Aliases for ADGRA2 Gene

Aliases for ADGRA2 Gene

  • Adhesion G Protein-Coupled Receptor A2 2 3 5
  • Tumor Endothelial Marker 5 2 3 4
  • G Protein-Coupled Receptor 124 2 3
  • G-Protein Coupled Receptor 124 3 4
  • GPR124 3 4
  • TEM5 3 4
  • KIAA1531 4

External Ids for ADGRA2 Gene

Previous HGNC Symbols for ADGRA2 Gene

  • GPR124

Summaries for ADGRA2 Gene

GeneCards Summary for ADGRA2 Gene

ADGRA2 (Adhesion G Protein-Coupled Receptor A2) is a Protein Coding gene. Among its related pathways are Integrins in angiogenesis. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRA1.

UniProtKB/Swiss-Prot for ADGRA2 Gene

  • Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).

Gene Wiki entry for ADGRA2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRA2 Gene

Genomics for ADGRA2 Gene

Regulatory Elements for ADGRA2 Gene

Enhancers for ADGRA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGRA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRA2 Gene

Chromosome:
8
Start:
37,784,191 bp from pter
End:
37,844,896 bp from pter
Size:
60,706 bases
Orientation:
Plus strand

Genomic View for ADGRA2 Gene

Genes around ADGRA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRA2 Gene

Proteins for ADGRA2 Gene

  • Protein details for ADGRA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PE1-AGRA2_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor A2
    Protein Accession:
    Q96PE1
    Secondary Accessions:
    • A6H8W3
    • D3DSW4
    • Q8N3R1
    • Q8TEM3
    • Q96KB2
    • Q9P1Z7
    • Q9UFY4

    Protein attributes for ADGRA2 Gene

    Size:
    1338 amino acids
    Molecular mass:
    142647 Da
    Quaternary structure:
    • Interacts (via PDZ-binding motif) with DLG1 (via PDZ domains) (PubMed:15021905). The cleaved extracellular subunit interacts with the integrin heterodimer ITGAV:ITGB3 (PubMed:16982628).
    SequenceCaution:
    • Sequence=AAI46775.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL11992.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO27354.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA96055.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRA2 Gene

Proteomics data for ADGRA2 Gene at MOPED

Post-translational modifications for ADGRA2 Gene

  • Glycosylated.
  • Proteolytically cleaved into two subunits, an extracellular subunit and a seven-transmembrane subunit (PubMed:22013897, PubMed:16982628). Cleaved by thrombin (F2) and MMP1 (PubMed:22013897). Also cleaved by MMP9, with lower efficiency (PubMed:22013897, PubMed:16982628). Presence of the protein disulfide-isomerase P4HB at the cell surface is additionally required for shedding of the extracellular subunit, suggesting that the subunits are linked by disulfide bonds (PubMed:22013897). Shedding is enhanced by the growth factor FGF2 and may promote cell survival during angiogenesis (PubMed:16982628).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGRA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGRA2 Gene

Domains & Families for ADGRA2 Gene

Suggested Antigen Peptide Sequences for ADGRA2 Gene

Graphical View of Domain Structure for InterPro Entry

Q96PE1

UniProtKB/Swiss-Prot:

AGRA2_HUMAN :
  • The leucine-rich repeats (LRRs) are important for potentiation of WNT7 signaling.
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
  • Contains 4 LRR (leucine-rich) repeats.
Domain:
  • The leucine-rich repeats (LRRs) are important for potentiation of WNT7 signaling.
  • The RGD motif is involved in integrin ITGAV:ITGB3 binding.
  • Contains 1 GPS domain.
  • Contains 1 Ig-like (immunoglobulin-like) domain.
  • Contains 1 LRRCT domain.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Similarity:
  • Contains 4 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with ADGRA2: view

Function for ADGRA2 Gene

Molecular function for ADGRA2 Gene

UniProtKB/Swiss-Prot Function:
Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628).

Gene Ontology (GO) - Molecular Function for ADGRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0005515 protein binding IEA,IPI 15021905
genes like me logo Genes that share ontologies with ADGRA2: view
genes like me logo Genes that share phenotypes with ADGRA2: view

Animal Models for ADGRA2 Gene

MGI Knock Outs for ADGRA2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADGRA2

miRNA for ADGRA2 Gene

miRTarBase miRNAs that target ADGRA2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADGRA2 Gene

Localization for ADGRA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRA2 Gene

Cell membrane; Multi-pass membrane protein. Cell projection, filopodium. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact. {ECO:0000269 PubMed:21421844}.

Gene Ontology (GO) - Cellular Components for ADGRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ADGRA2: view

No data available for Subcellular locations from COMPARTMENTS for ADGRA2 Gene

Pathways & Interactions for ADGRA2 Gene

SuperPathways for ADGRA2 Gene

Superpath Contained pathways
1 Integrins in angiogenesis
genes like me logo Genes that share pathways with ADGRA2: view

Pathways by source for ADGRA2 Gene

1 BioSystems pathway for ADGRA2 Gene

Gene Ontology (GO) - Biological Process for ADGRA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007417 central nervous system development IEA,ISS --
GO:0045765 regulation of angiogenesis IEA,ISS --
GO:0090210 regulation of establishment of blood-brain barrier IEA --
GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway IEA --
genes like me logo Genes that share ontologies with ADGRA2: view

No data available for SIGNOR curated interactions for ADGRA2 Gene

Drugs & Compounds for ADGRA2 Gene

No Compound Related Data Available

Transcripts for ADGRA2 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRA2 Gene

No ASD Table

Relevant External Links for ADGRA2 Gene

GeneLoc Exon Structure for
ADGRA2
ECgene alternative splicing isoforms for
ADGRA2

Expression for ADGRA2 Gene

mRNA expression in normal human tissues for ADGRA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRA2 Gene

This gene is overexpressed in Placenta (13.2), Fetal gut (8.6), Heart (8.0), Fetal testis (6.9), and Prostate (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRA2 Gene



mRNA Expression by UniProt/SwissProt for ADGRA2 Gene

Q96PE1-AGRA2_HUMAN
Tissue specificity: Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628). Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905).
genes like me logo Genes that share expression patterns with ADGRA2: view

Protein tissue co-expression partners for ADGRA2 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ADGRA2 Gene

Orthologs for ADGRA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRA2 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia GPR124 35
  • 88.97 (n)
  • 90.78 (a)
GPR124 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gpr124 35
  • 84.4 (n)
  • 88.07 (a)
Adgra2 16
Gpr124 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR124 35
  • 99.45 (n)
  • 99.48 (a)
GPR124 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100363275 35
  • 84.16 (n)
  • 87.71 (a)
cow
(Bos Taurus)
Mammalia GPR124 36
  • 50 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR124 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GPR124 36
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR124 35
  • 72.58 (n)
  • 68.33 (a)
GPR124 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GPR124 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr124 35
  • 61.76 (n)
  • 60.21 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC69043 35
zebrafish
(Danio rerio)
Actinopterygii gpr124 35
  • 60.01 (n)
  • 57.72 (a)
gpr124 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG15744 36
  • 15 (a)
OneToMany
Species with no ortholog for ADGRA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRA2 Gene

ENSEMBL:
Gene Tree for ADGRA2 (if available)
TreeFam:
Gene Tree for ADGRA2 (if available)

Paralogs for ADGRA2 Gene

Paralogs for ADGRA2 Gene

genes like me logo Genes that share paralogs with ADGRA2: view

Variants for ADGRA2 Gene

Sequence variations from dbSNP and Humsavar for ADGRA2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_072079 -
VAR_072561 -
rs2070494 -- 37,831,215(-) CAATA(A/G)TATCT intron-variant
rs2070495 -- 37,831,178(-) AATCT(A/G)GTGCC intron-variant
rs2212045 -- 37,828,660(-) aaaat(A/C)caaaa intron-variant

Variation tolerance for ADGRA2 Gene

Residual Variation Intolerance Score: 21.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.53; 72.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGRA2 Gene

Disorders for ADGRA2 Gene

Relevant External Links for ADGRA2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRA2

No disorders were found for ADGRA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRA2 Gene

Publications for ADGRA2 Gene

  1. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 67
  2. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3
  3. Cell surface tumor endothelial markers are conserved in mice and humans. (PMID: 11559528) Carson-Walter E.B. … St Croix B. (Cancer Res. 2001) 2 3
  4. miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124. (PMID: 24582749) Gao Y. … Fu X. (Biochem. Biophys. Res. Commun. 2014) 3
  5. Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. (PMID: 24144296) Cheng C.Y. … Baird P.N. (Am. J. Hum. Genet. 2013) 3

Products for ADGRA2 Gene

Sources for ADGRA2 Gene

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