Aliases for ADGRA1 Gene
Aliases for ADGRA1 Gene
External Ids for ADGRA1 Gene
- HGNC: 13838
- Entrez Gene: 84435
- Ensembl: ENSG00000197177
- OMIM: 612302
- UniProtKB: Q86SQ6
Previous HGNC Symbols for ADGRA1 Gene
- GPR123
Summaries for ADGRA1 Gene
-
This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]
GeneCards Summary for ADGRA1 Gene
ADGRA1 (Adhesion G Protein-Coupled Receptor A1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRA3.
UniProtKB/Swiss-Prot for ADGRA1 Gene
-
Orphan receptor.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRA1 Gene
Genomics for ADGRA1 Gene
Regulatory Elements for ADGRA1 Gene
Enhancers for ADGRA1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH10G132930 | 0.8 | Ensembl ENCODE | 11.2 | -139.7 | -139733 | 2.0 | ZFHX2 GLIS1 EED ATF2 WT1 RELA EGR2 | ADGRA1 CFAP46 PIR56661 |
| GH10G133150 | 0.7 | ENCODE | 11 | +80.7 | 80729 | 2.1 | BCOR RNF2 MNT RBBP5 GLI4 JUND CBX8 POLR2A HDAC2 ZNF580 | KNDC1 ADGRA1 ZNF511 TUBGCP2 NKX6-2 RPL5P28 |
| GH10G133109 | 0.5 | ENCODE | 11.9 | +39.3 | 39278 | 1.8 | GATA2 ZNF26 NR3C1 NR2F2 | SCART1 ADGRA1 PIR56333 GC10M133145 |
| GH10G133043 | 0.4 | ENCODE | 12.5 | -26.4 | -26380 | 1.2 | KLF1 REST | ADGRA1 CFAP46 LOC102723337 |
| GH10G133103 | 0.5 | ENCODE | 6.8 | +33.5 | 33476 | 1.1 | RING1 MXI1 ZNF341 EP300 | ADGRA1 GC10M133102 PIR56333 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ADGRA1 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for ADGRA1 Gene
- Chromosome:
- 10
- Start:
- 133,070,929 bp from pter
- End:
- 133,131,675 bp from pter
- Size:
- 60,747 bases
- Orientation:
- Plus strand
Genomic View for ADGRA1 Gene
Genes around ADGRA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q26.3 by Ensembl
- 10q26.3 by Entrez Gene
- 10q26.3 by HGNC
ADGRA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADGRA1 Gene
Proteins for ADGRA1 Gene
-
Protein details for ADGRA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86SQ6-AGRA1_HUMAN
- Recommended name:
- Adhesion G protein-coupled receptor A1
- Protein Accession:
- Q86SQ6
- A5HL16
- A6NG50
- Q5T234
- Q86SN7
- Q96JJ9
Protein attributes for ADGRA1 Gene
- Size:
- 560 amino acids
- Molecular mass:
- 60885 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAB47457.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for ADGRA1 Gene
Post-translational modifications for ADGRA1 Gene
Other Protein References for ADGRA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for ADGRA1
- Invitrogen Antibodies for ADGRA1
- Invitrogen Antibodies for ADGRA1
- antibodies-online Antibodies for ADGRA1: See all 13
- GeneTex ADGRA1 antibody for ADGRA1
- GeneTex Epha4 antibody for ADGRA1
Protein Products
-
OriGene Purified Proteins for ADGRA1
- Search Origene for MassSpec and Protein Over-expression Lysates for ADGRA1
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- Novus Biologicals proteins for ADGRA1
- Search GeneTex for Proteins for ADGRA1
Assay Products
No data available for DME Specific Peptides for ADGRA1 Gene
Domains & Families for ADGRA1 Gene
Gene Families for ADGRA1 Gene
Protein Domains for ADGRA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADGRA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q86SQ6UniProtKB/Swiss-Prot:
AGRA1_HUMAN :- Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
- Family:
-
- Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Function for ADGRA1 Gene
Molecular function for ADGRA1 Gene
- UniProtKB/Swiss-Prot Function:
- Orphan receptor.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | TAS,NAS | 12565841 |
Phenotypes for ADGRA1 Gene
- MGI mutant phenotypes for ADGRA1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADGRA1:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADGRA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADGRA1 gene
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CRISPR Products
-
OriGene CRISPR knockouts for ADGRA1
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miRNA for ADGRA1 Gene
- miRTarBase miRNAs that target ADGRA1
miRNA Products
- Search ViGene Biosciences for ADGRA1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ADGRA1
- Browse OriGene Inhibitory RNA Products For ADGRA1
-
ViGene Biosciences ready-to-package AAV shRNAs for ADGRA1 gene
Clone Products
-
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- Addgene plasmids for ADGRA1
- VectorBuilder custom plasmid, inducible vectors for ADGRA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADGRA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ADGRA1 (GPR123)
Cell Line Products
-
Horizon Cell Lines for ADGRA1
-
ViGene Biosciences adenoviral particle packaged cDNA for ADGRA1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADGRA1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADGRA1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRA1 Gene
Localization for ADGRA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADGRA1 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | TAS,NAS | 12565841 |
Pathways & Interactions for ADGRA1 Gene
No Data Available
Interacting Proteins for ADGRA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | NAS | 17212699 |
| GO:0007166 | cell surface receptor signaling pathway | IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS,IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for ADGRA1 Gene
Transcripts for ADGRA1 Gene
mRNA/cDNA for ADGRA1 Gene
- (6) REFSEQ mRNAs :
- (30) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ADGRA1
- GenScript: Design CRISPR guide RNA sequences for ADGRA1
miRNA Products
- Search ViGene Biosciences for ADGRA1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ADGRA1
- Browse OriGene Inhibitory RNA Products For ADGRA1
-
ViGene Biosciences ready-to-package AAV shRNAs for ADGRA1 gene
Clone Products
-
OriGene ORF clones in human for ADGRA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- Addgene plasmids for ADGRA1
- VectorBuilder custom plasmid, inducible vectors for ADGRA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADGRA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ADGRA1 (GPR123)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP4: |
Expression for ADGRA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Frontal cortex (29.0), Lymph node (20.1), and Adipocyte (19.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADGRA1 Gene:
ADGRA1Evidence on tissue expression from TISSUES for ADGRA1 Gene
- Nervous system(4.2)
Primer Products
-
OriGene qPCR primer pairs for ADGRA1
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRA1 Gene
Orthologs for ADGRA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | GPR123 35 34 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gpr123 35 34 |
|
OneToOne | |
| Adgra1 16 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | Gpr123 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | GPR123 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | GPR123 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | GPR123 35 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | GPR123 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | GPR123 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | gpr123 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC560847 34 |
|
||
| GPR123 (2 of 4) 35 |
|
OneToMany | |||
| gpr123 35 |
|
OneToMany | |||
| GPR123 (3 of 4) 35 |
|
OneToMany | |||
| CABZ01086759.2 35 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | CG15744 35 |
|
OneToMany |
- Species where no ortholog for ADGRA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ADGRA1 Gene
Variants for ADGRA1 Gene
| SNP ID | Clin | Chr 10 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000006828 | -- | 133,107,282(+) | CCATC(C/T)GTACA | intron-variant, downstream-variant-500B | |
| rs1000016399 | -- | 133,076,695(+) | TTTCA(C/T)AGACT | intron-variant | |
| rs1000020339 | -- | 133,129,964(+) | AGATC(A/G)CAGGA | utr-variant-3-prime | |
| rs1000038962 | -- | 133,118,591(+) | AAGGG(A/G)GAAGA | intron-variant | |
| rs1000087381 | -- | 133,103,909(+) | CTGGG(G/T)CTCCC | intron-variant |
Residual Variation Intolerance Score:
28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.90;
74.31% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ADGRA1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADGRA1
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRA1 Gene
Disorders for ADGRA1 Gene
Relevant External Links for ADGRA1
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- ADGRA1
No disorders were found for ADGRA1 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRA1 Gene
Publications for ADGRA1 Gene
- International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 64
- There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 64
- The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
- The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
- Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64
Products for ADGRA1 Gene
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- Novus Biologicals Antibodies for ADGRA1
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- Invitrogen Antibodies for ADGRA1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ADGRA1
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- Search GeneTex for Proteins for ADGRA1
- ViGene Biosciences adenoviral particle packaged cDNA for ADGRA1 gene
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- Horizon Cell Lines for ADGRA1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADGRA1
- VectorBuilder custom plasmid, inducible vectors for ADGRA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADGRA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ADGRA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
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- (141) ENCODE
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- (143) Horizon
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- (148) SNPedia
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- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer