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Aliases for ADGRA1 Gene

Aliases for ADGRA1 Gene

  • Adhesion G Protein-Coupled Receptor A1 2 3 5
  • G-Protein Coupled Receptor 123 3 4
  • GPR123 3 4
  • Probable G-Protein Coupled Receptor 123 3
  • G Protein-Coupled Receptor 123 2
  • KIAA1828 4

External Ids for ADGRA1 Gene

Previous HGNC Symbols for ADGRA1 Gene

  • GPR123

Summaries for ADGRA1 Gene

Entrez Gene Summary for ADGRA1 Gene

  • This gene encodes a protein that belongs to the adhesion family of G-protein-coupled receptors. Members of this family function in several sensory systems and regulate blood pressure, immune responses, food intake and development. A similar protein in rodents is thought to play a role in in the regulation of neuronal signaling pathways. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Mar 2014]

GeneCards Summary for ADGRA1 Gene

ADGRA1 (Adhesion G Protein-Coupled Receptor A1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is ADGRA3.

UniProtKB/Swiss-Prot for ADGRA1 Gene

  • Orphan receptor.

Gene Wiki entry for ADGRA1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGRA1 Gene

Genomics for ADGRA1 Gene

Regulatory Elements for ADGRA1 Gene

Enhancers for ADGRA1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G132930 0.8 Ensembl ENCODE 11.2 -139.7 -139733 2.0 ZFHX2 GLIS1 EED ATF2 WT1 RELA EGR2 ADGRA1 CFAP46 PIR56661
GH10G133150 0.7 ENCODE 11 +80.7 80729 2.1 BCOR RNF2 MNT RBBP5 GLI4 JUND CBX8 POLR2A HDAC2 ZNF580 KNDC1 ADGRA1 ZNF511 TUBGCP2 NKX6-2 RPL5P28
GH10G133109 0.5 ENCODE 11.9 +39.3 39278 1.8 GATA2 ZNF26 NR3C1 NR2F2 SCART1 ADGRA1 PIR56333 GC10M133145
GH10G133043 0.4 ENCODE 12.5 -26.4 -26380 1.2 KLF1 REST ADGRA1 CFAP46 LOC102723337
GH10G133103 0.5 ENCODE 6.8 +33.5 33476 1.1 RING1 MXI1 ZNF341 EP300 ADGRA1 GC10M133102 PIR56333
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGRA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGRA1 Gene

Chromosome:
10
Start:
133,070,929 bp from pter
End:
133,131,675 bp from pter
Size:
60,747 bases
Orientation:
Plus strand

Genomic View for ADGRA1 Gene

Genes around ADGRA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGRA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGRA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGRA1 Gene

Proteins for ADGRA1 Gene

  • Protein details for ADGRA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SQ6-AGRA1_HUMAN
    Recommended name:
    Adhesion G protein-coupled receptor A1
    Protein Accession:
    Q86SQ6
    Secondary Accessions:
    • A5HL16
    • A6NG50
    • Q5T234
    • Q86SN7
    • Q96JJ9

    Protein attributes for ADGRA1 Gene

    Size:
    560 amino acids
    Molecular mass:
    60885 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB47457.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGRA1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGRA1 Gene

Post-translational modifications for ADGRA1 Gene

  • Glycosylation at Asn795
  • Modification sites at PhosphoSitePlus

Other Protein References for ADGRA1 Gene

No data available for DME Specific Peptides for ADGRA1 Gene

Domains & Families for ADGRA1 Gene

Gene Families for ADGRA1 Gene

Suggested Antigen Peptide Sequences for ADGRA1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86SQ6

UniProtKB/Swiss-Prot:

AGRA1_HUMAN :
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
Family:
  • Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.
genes like me logo Genes that share domains with ADGRA1: view

Function for ADGRA1 Gene

Molecular function for ADGRA1 Gene

UniProtKB/Swiss-Prot Function:
Orphan receptor.

Gene Ontology (GO) - Molecular Function for ADGRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004888 transmembrane signaling receptor activity IEA --
GO:0004930 G-protein coupled receptor activity TAS,NAS 12565841
genes like me logo Genes that share ontologies with ADGRA1: view

Phenotypes for ADGRA1 Gene

genes like me logo Genes that share phenotypes with ADGRA1: view

Animal Model Products

miRNA for ADGRA1 Gene

miRTarBase miRNAs that target ADGRA1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGRA1 Gene

Localization for ADGRA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADGRA1 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGRA1 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for ADGRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,NAS 12565841
genes like me logo Genes that share ontologies with ADGRA1: view

Pathways & Interactions for ADGRA1 Gene

SuperPathways for ADGRA1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADGRA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 17212699
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS,IEA --
genes like me logo Genes that share ontologies with ADGRA1: view

No data available for Pathways by source and SIGNOR curated interactions for ADGRA1 Gene

Drugs & Compounds for ADGRA1 Gene

No Compound Related Data Available

Transcripts for ADGRA1 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGRA1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4:

Relevant External Links for ADGRA1 Gene

GeneLoc Exon Structure for
ADGRA1
ECgene alternative splicing isoforms for
ADGRA1

Expression for ADGRA1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGRA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADGRA1 Gene

This gene is overexpressed in Frontal cortex (29.0), Lymph node (20.1), and Adipocyte (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGRA1 Gene



Protein tissue co-expression partners for ADGRA1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGRA1 Gene:

ADGRA1

Evidence on tissue expression from TISSUES for ADGRA1 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ADGRA1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGRA1 Gene

Orthologs for ADGRA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADGRA1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GPR123 34 35
  • 83.51 (n)
mouse
(Mus musculus)
Mammalia Gpr123 34 35
  • 81.02 (n)
Adgra1 16
rat
(Rattus norvegicus)
Mammalia Gpr123 34
  • 80.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia GPR123 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GPR123 35
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GPR123 35
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia GPR123 35
  • 46 (a)
OneToOne
chicken
(Gallus gallus)
Aves GPR123 35
  • 30 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
OneToMany
-- 35
  • 4 (a)
OneToMany
-- 35
  • 1 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia gpr123 34
  • 65.29 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC560847 34
  • 62.25 (n)
GPR123 (2 of 4) 35
  • 47 (a)
OneToMany
gpr123 35
  • 43 (a)
OneToMany
GPR123 (3 of 4) 35
  • 32 (a)
OneToMany
CABZ01086759.2 35
  • 6 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG15744 35
  • 6 (a)
OneToMany
Species where no ortholog for ADGRA1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGRA1 Gene

ENSEMBL:
Gene Tree for ADGRA1 (if available)
TreeFam:
Gene Tree for ADGRA1 (if available)

Paralogs for ADGRA1 Gene

Paralogs for ADGRA1 Gene

genes like me logo Genes that share paralogs with ADGRA1: view

Variants for ADGRA1 Gene

Sequence variations from dbSNP and Humsavar for ADGRA1 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000006828 -- 133,107,282(+) CCATC(C/T)GTACA intron-variant, downstream-variant-500B
rs1000016399 -- 133,076,695(+) TTTCA(C/T)AGACT intron-variant
rs1000020339 -- 133,129,964(+) AGATC(A/G)CAGGA utr-variant-3-prime
rs1000038962 -- 133,118,591(+) AAGGG(A/G)GAAGA intron-variant
rs1000087381 -- 133,103,909(+) CTGGG(G/T)CTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGRA1 Gene

Variant ID Type Subtype PubMed ID
dgv1464n54 CNV gain 21841781
dgv1465n54 CNV loss 21841781
dgv1466n54 CNV gain+loss 21841781
dgv1467n54 CNV loss 21841781
dgv1468n54 CNV gain 21841781
dgv1469n54 CNV loss 21841781
dgv179e199 CNV deletion 23128226
dgv528e59 CNV duplication 20981092
dgv998n100 CNV gain 25217958
esv1144764 CNV insertion 17803354
esv1201179 CNV insertion 17803354
esv1303257 CNV insertion 17803354
esv1960799 CNV deletion 18987734
esv2369077 CNV deletion 18987734
esv25517 CNV loss 19812545
esv2743816 CNV deletion 23290073
esv2743817 CNV deletion 23290073
esv2743818 CNV deletion 23290073
esv2743819 CNV deletion 23290073
esv2743821 CNV deletion 23290073
esv2743822 CNV deletion 23290073
esv2743823 CNV deletion 23290073
esv2743824 CNV deletion 23290073
esv2743825 CNV deletion 23290073
esv2743826 CNV deletion 23290073
esv2759793 CNV gain+loss 17122850
esv2760107 CNV gain 21179565
esv3625015 CNV gain 21293372
esv3625022 CNV gain 21293372
nsv1054934 CNV gain 25217958
nsv1124631 CNV duplication 24896259
nsv1145493 CNV deletion 24896259
nsv24013 CNV deletion 16902084
nsv24899 CNV deletion 16902084
nsv467498 CNV gain 19166990
nsv470979 CNV loss 18288195
nsv528260 CNV loss 19592680
nsv552526 CNV gain 21841781
nsv552539 CNV loss 21841781
nsv552540 CNV loss 21841781
nsv552543 CNV gain 21841781
nsv552555 CNV loss 21841781
nsv552556 CNV gain 21841781
nsv552567 CNV gain+loss 21841781
nsv552568 CNV gain 21841781
nsv832036 CNV loss 17160897
nsv8749 CNV loss 18304495
nsv952703 CNV deletion 24416366

Variation tolerance for ADGRA1 Gene

Residual Variation Intolerance Score: 28.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.90; 74.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGRA1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGRA1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGRA1 Gene

Disorders for ADGRA1 Gene

Relevant External Links for ADGRA1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGRA1

No disorders were found for ADGRA1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGRA1 Gene

Publications for ADGRA1 Gene

  1. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. (PMID: 25713288) Hamann J. … SchiAPth H.B. (Pharmacol. Rev. 2015) 2 3 4 64
  2. There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini. (PMID: 12565841) Fredriksson R. … Schioeth H.B. (Biochem. Biophys. Res. Commun. 2003) 2 3 4 64
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  4. The G protein-coupled receptor repertoires of human and mouse. (PMID: 12679517) Vassilatis D.K. … Gaitanaris G.A. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4 64

Products for ADGRA1 Gene

Sources for ADGRA1 Gene

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