ADGB Gene
protein-coding GIFtS: 37
GCID: GC06P146920
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|
androglobin(Previous name: chromosome 6 open reading frame 103 )
(Previous symbol: C6orf103)
| |
Aliases
for ADGB gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Androglobin1 | | Chromosome 6 Open Reading Frame 1031 | | C6orf1031 2 3 | | DJ408K24.11 | | Calpain-7-Like Protein2 3 | | CAPN7L3 | | FLJ231211 | | |
Export aliases for ADGB gene to outside databases |
Summaries
for ADGB gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ADGB gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ADGB
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADGB
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADGB |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q24.3 Ensembl cytogenetic band: 6q24.3 HGNC cytogenetic band: 6q24.2ADGB Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P146920: view genomic region
(about GC identifiers)
Start:
|
146,920,101 bp from pter |
End:
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147,136,598 bp from pter |
Size:
|
216,498 bases |
Orientation:
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plus strand |
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Proteins
for ADGB gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADGB_HUMAN, Q8N7X0 (See
protein sequence)Recommended Name: Androglobin Size: 1667 amino acids; 189713 Da
Caution: Lacks the conserved active site residues. Probably catalytically inactive
Sequence caution: Sequence=AL832192; Type=Frameshift; Positions=81, 281, 581; Sequence=AL832192; Type=Miscellaneousdiscrepancy; Note=Intron retention; Sequence=CAI16490.1; Type=Erroneous gene model prediction; Sequence=CAI20488.1;Type=Erroneous gene model prediction; Sequence=DN831198; Type=Frameshift; Positions=944, 946, 960;
Secondary accessions: Q5T402 Q5T904 Q5T905Alternative splicing: 2 isoforms: Q8N7X0-1 Q8N7X0-2 (Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for ADGB: NX_Q8N7X0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N7X0
ADGB Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_078970.3
ENSEMBL proteins: ENSP00000381036 ENSP00000429365 ENSP00000428035 ENSP00000430244 ENSP00000430834 ENSP00000429315 ENSP00000356460 ENSP00000323839 ENSP00000427779 ENSP00000356459 ENSP00000356463 ENSP00000356458
Human Recombinant Protein Products for ADGB:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ADGB for ontologies About GeneDecksing
ADGB Antibody Products:
Assay Products for ADGB: |
Protein
Domains /
Families
for ADGB gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADGB for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N7X0ProtoNet protein and cluster: Q8N7X0 UniProtKB/Swiss-Prot: ADGB_HUMAN, Q8N7X0Similarity: Belongs to the peptidase C2 familySimilarity: Contains 1 calpain catalytic domainSimilarity: Contains 1 IQ domain |
Function
for ADGB gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004198 | calcium-dependent cysteine-type endopeptidase activity |
IEA | -- | | GO:0005506 | iron ion binding |
IEA | -- | | GO:0019825 | oxygen binding |
IEA | -- | | GO:0020037 | heme binding |
IEA | -- |
ADGB for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADGB
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADGB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for ADGB | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADGB | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADGB |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADGB |
|
Pathways & Interactions
for ADGB gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADGB
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ADGB (ENSP000003810364) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
ADGB for ontologies About GeneDecksing
|
Drugs & Compounds
for ADGB gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADGB
Search CenterWatch for drugs/clinical trials and news about ADGB
|
Transcripts
for ADGB gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADGB gene: NM_024694.3 Unigene Cluster for ADGB: Androglobin Hs.720870 [show with all ESTs]Unigene Representative Sequence: AL83219214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397944(uc010khx.3 uc003qlq.3 uc003qlr.3) ENST00000522396
ENST00000522242 ENST00000326929 ENST00000493950(uc003qlp.3) ENST00000473647
ENST00000480328 ENST00000367490 ENST00000326916 ENST00000523560 ENST00000470716
ENST00000367489 ENST00000367493 ENST00000367488
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADGB
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADGB
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for ADGB | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADGB | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADGB |
Additional cDNA sequence: AK026774.1 AK097570.1 AL832192.1 7 DOTS entries: DT.203262 DT.99930890 DT.100741529 DT.40218594 DT.121340525 DT.97827093 DT.92428034 24/59 AceView cDNA sequences (see all 59): BC067801 AL832192 BX094442 CN479076 AA397725 AW104668 AK097570 AA421124 AA442621 BG701048 BV174966 BF056902 BI826804 BG190974 BG183751 AI208131 AA400861 BV204644 BG722400 BU854014 AK026774 AW182431 BE045997 BG186413
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for ADGB About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24a | · | 24b | ^ |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | · | 29c | ^ | 30 | ^ | 31 | ^ | 32 |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ADGB
|
Expression
for ADGB gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADGB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGCTGGAGA
About this image
See ADGB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADGB
SOURCE GeneReport for Unigene cluster: Hs.720870
SABiosciences Custom PCR Arrays for ADGB
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADGB
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ADGB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADGB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADGB | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADGB |
Orthologs
for ADGB gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADGB gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for ADGB (if available)
TreeFam Gene Tree for ADGB (if available) |
Paralogs
for ADGB gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ADGB gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADGB (146920101 - 147136598 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADGB: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADGB |
|
Disorders
/ Diseases
for ADGB gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADGB for disorders About GeneDecksing
OMIM gene information: 614630
OMIM disorders: --
1  disease for ADGB: About MalaCardsleprosy
Export disorders for ADGB gene to outside databases
|
Publications
for ADGB gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADGB gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADGB) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Androglobin: a chimeric globin in metazoans that is p referentially expressed in Mammalian testes. (PubMed id 22115833)1, 3 Hoogewijs D....Hankeln T. (2012)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Identification of two new loci at IL23R and RAB32 tha t influence susceptibility to leprosy. (PubMed id 22019778)1 Zhang F....Zhang X. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
|
External Searches for ADGB gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADGB gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADGB gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADGB gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADGB | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADGB gene:
Search GeneIP for patents involving ADGB
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADGB gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADGB | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADGB | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADGB | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADGB | | OriGene 3'-UTR Clone for ADGB | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADGB | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADGB | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADGB | | OriGene Custom Protein Services for ADGB | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADGB | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADGB | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADGB | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADGB | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADGB | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADGB |
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 |  |  |  | |
| | | | Search Tocris compounds for ADGB |
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 | | | ADGB Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADGB |
|  |  |  |  | | | | Search ThermoFisher Antibodies for ADGB |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADGB |
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