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Aliases for ADGB Gene

Aliases for ADGB Gene

  • Androglobin 2 3 3 5
  • Calpain-7-Like Protein 3 4
  • C6orf103 3 4
  • Chromosome 6 Open Reading Frame 103 2
  • CAPN16 3
  • CAPN7L 4

External Ids for ADGB Gene

Previous HGNC Symbols for ADGB Gene

  • C6orf103

Previous GeneCards Identifiers for ADGB Gene

  • GC06P146920

Summaries for ADGB Gene

GeneCards Summary for ADGB Gene

ADGB (Androglobin) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxygen binding.

Additional gene information for ADGB Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGB Gene

Genomics for ADGB Gene

Regulatory Elements for ADGB Gene

Enhancers for ADGB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H146770 1.1 Ensembl ENCODE 15.7 +171.9 171947 1.4 HDAC1 ZBTB40 CHAMP1 TCF12 ZNF766 ELK1 ETV6 RUNX3 CREM ZBTB11 ADGB LOC105378040 LOC105378041
GH06H146542 1.4 FANTOM5 ENCODE 10.9 -53.6 -53620 4.8 ARNT ARID4B DMAP1 BRCA1 YY1 ZNF766 ELK1 ZNF143 ATF7 ZNF202 SHPRH ADGB LOC101928661 RAB32 GC06M146554
GH06H146548 1.3 FANTOM5 ENCODE 10.9 -50.0 -49970 0.2 ATF1 ARNT TCF12 ZNF766 GATA2 ELK1 ATF7 NCOA1 SMARCB1 MEF2D LOC101928661 ADGB GC06M146554 RAB32
GH06H146857 1.6 Ensembl ENCODE dbSUPER 7.8 +258.9 258889 1.5 HDGF ARID4B FEZF1 DMAP1 ZNF2 ZNF766 CBX5 ZNF143 FOS ZHX2 ADGB STXBP5 LOC105378042 ENSG00000272397
GH06H146912 1.8 FANTOM5 ENCODE dbSUPER 6.8 +316.0 316026 5 HDGF PKNOX1 ARNT FEZF1 ZNF766 FOS SP3 REST SMARCB1 ZNF592 STXBP5-AS1 SHPRH ADGB STXBP5 RAB32 ENSG00000272397 LOC105378042
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGB on UCSC Golden Path with GeneCards custom track

Promoters for ADGB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000204638 36 800 MXI1 MAZ SP3 RFX1 SAP130 ARID4B BMI1 E2F1 SREBF1 ZFHX2

Genomic Locations for ADGB Gene

Genomic Locations for ADGB Gene
216,498 bases
Plus strand

Genomic View for ADGB Gene

Genes around ADGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGB Gene

Proteins for ADGB Gene

  • Protein details for ADGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q5T402
    • Q5T904
    • Q5T905

    Protein attributes for ADGB Gene

    1667 amino acids
    Molecular mass:
    189713 Da
    Quaternary structure:
    No Data Available
    • Sequence=AL832192; Type=Frameshift; Positions=81, 281, 581; Evidence={ECO:0000305}; Sequence=AL832192; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI16490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=DN831198; Type=Frameshift; Positions=944, 946, 960; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGB Gene


neXtProt entry for ADGB Gene

Post-translational modifications for ADGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGB Gene

Domains & Families for ADGB Gene

Gene Families for ADGB Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for ADGB Gene

Suggested Antigen Peptide Sequences for ADGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the peptidase C2 family.
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with ADGB: view

Function for ADGB Gene

Phenotypes From GWAS Catalog for ADGB Gene

Gene Ontology (GO) - Molecular Function for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
genes like me logo Genes that share ontologies with ADGB: view

Animal Model Products

miRNA for ADGB Gene

miRTarBase miRNAs that target ADGB

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGB Gene

Localization for ADGB Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGB gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (1)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ADGB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADGB Gene

Pathways & Interactions for ADGB Gene

No Data Available

Interacting Proteins for ADGB Gene

Gene Ontology (GO) - Biological Process for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA,IBA --
genes like me logo Genes that share ontologies with ADGB: view

No data available for Pathways by source and SIGNOR curated interactions for ADGB Gene

Drugs & Compounds for ADGB Gene

No Compound Related Data Available

Transcripts for ADGB Gene

Unigene Clusters for ADGB Gene

Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32
SP2: - -
SP5: -

Relevant External Links for ADGB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADGB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGB Gene

mRNA differential expression in normal tissues according to GTEx for ADGB Gene

This gene is overexpressed in Testis (x22.5) and Fallopian Tube (x6.7).

Protein differential expression in normal tissues from HIPED for ADGB Gene

This gene is overexpressed in Blymphocyte (26.7), Plasma (18.6), CD4 Tcells (14.8), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGB Gene

NURSA nuclear receptor signaling pathways regulating expression of ADGB Gene:


SOURCE GeneReport for Unigene cluster for ADGB Gene:

genes like me logo Genes that share expression patterns with ADGB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGB Gene

Orthologs for ADGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC472148 33
  • 98.63 (n)
  • 98 (a)
(Canis familiaris)
Mammalia ADGB 33 34
  • 85.76 (n)
(Bos Taurus)
Mammalia ADGB 33 34
  • 84.96 (n)
(Rattus norvegicus)
Mammalia Adgb 33
  • 78.2 (n)
(Mus musculus)
Mammalia Adgb 33 16 34
  • 78.16 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 74 (a)
-- 34
  • 69 (a)
-- 34
  • 61 (a)
-- 34
  • 58 (a)
-- 34
  • 47 (a)
-- 34
  • 47 (a)
(Monodelphis domestica)
Mammalia ADGB 34
  • 57 (a)
(Gallus gallus)
Aves C3H6ORF103 33
  • 61.62 (n)
  • 48 (a)
(Anolis carolinensis)
Reptilia ADGB 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adgb 33
  • 59.12 (n)
(Danio rerio)
Actinopterygii adgb 33 34
  • 54.99 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 55 (a)
Species where no ortholog for ADGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGB Gene

Gene Tree for ADGB (if available)
Gene Tree for ADGB (if available)

Paralogs for ADGB Gene

No data available for Paralogs for ADGB Gene

Variants for ADGB Gene

Sequence variations from dbSNP and Humsavar for ADGB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000004379 -- 146,640,299(+) GGGAC(A/C)TGATG intron-variant
rs1000009915 -- 146,682,260(+) TCTTA(C/T)GTATT intron-variant
rs1000026708 -- 146,776,329(+) CCTGT(A/G)AAGCT intron-variant
rs1000053788 -- 146,755,715(+) AGTCC(A/C)TTTGC intron-variant
rs1000054393 -- 146,776,065(+) TCTGG(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGB Gene

Variant ID Type Subtype PubMed ID
nsv981192 CNV duplication 23825009
nsv969453 CNV duplication 23825009
nsv830838 CNV gain 17160897
nsv349025 CNV deletion 16902084
nsv1118001 CNV deletion 24896259
nsv1032168 CNV loss 25217958
esv3611158 CNV gain 21293372
esv3611157 CNV loss 21293372
esv3422508 CNV insertion 20981092
esv2762619 CNV loss 21179565
esv2732839 CNV deletion 23290073
esv2732838 CNV deletion 23290073
esv2732837 CNV deletion 23290073
esv2732836 CNV deletion 23290073
esv2732835 CNV deletion 23290073
esv2732834 CNV deletion 23290073
esv2674520 CNV deletion 23128226
esv2665277 CNV deletion 23128226
esv2596411 CNV deletion 19546169
esv2518343 CNV deletion 19546169
esv2451551 CNV deletion 19546169
esv2159904 CNV deletion 18987734
esv2045633 CNV deletion 18987734
esv1011004 CNV deletion 20482838
dgv1022e201 CNV deletion 23290073

Variation tolerance for ADGB Gene

Gene Damage Index Score: 10.76; 91.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGB Gene

Disorders for ADGB Gene

Relevant External Links for ADGB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADGB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGB Gene

Publications for ADGB Gene

  1. Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes. (PMID: 22115833) Hoogewijs D … Hankeln T (Molecular biology and evolution 2012) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 60
  4. Androglobin knockdown inhibits growth of glioma cell lines. (PMID: 24966926) Huang B … Hu ZL (International journal of clinical and experimental pathology 2014) 3 60
  5. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PMID: 22019778) Zhang F … Zhang X (Nature genetics 2011) 3 60

Products for ADGB Gene

Sources for ADGB Gene

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