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Aliases for ADGB Gene

Aliases for ADGB Gene

  • Androglobin 2 3 5
  • Calpain-7-Like Protein 3 4
  • C6orf103 3 4
  • Chromosome 6 Open Reading Frame 103 2
  • CAPN16 3
  • CAPN7L 4

External Ids for ADGB Gene

Previous HGNC Symbols for ADGB Gene

  • C6orf103

Previous GeneCards Identifiers for ADGB Gene

  • GC06P146920

Summaries for ADGB Gene

GeneCards Summary for ADGB Gene

ADGB (Androglobin) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxygen binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGB Gene

Genomics for ADGB Gene

Regulatory Elements for ADGB Gene

Enhancers for ADGB Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADGB on UCSC Golden Path with GeneCards custom track

Promoters for ADGB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADGB on UCSC Golden Path with GeneCards custom track

Genomic Location for ADGB Gene

Chromosome:
6
Start:
146,598,965 bp from pter
End:
146,815,462 bp from pter
Size:
216,498 bases
Orientation:
Plus strand

Genomic View for ADGB Gene

Genes around ADGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGB Gene

Proteins for ADGB Gene

  • Protein details for ADGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7X0-ADGB_HUMAN
    Recommended name:
    Androglobin
    Protein Accession:
    Q8N7X0
    Secondary Accessions:
    • Q5T402
    • Q5T904
    • Q5T905

    Protein attributes for ADGB Gene

    Size:
    1667 amino acids
    Molecular mass:
    189713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AL832192; Type=Frameshift; Positions=81, 281, 581; Evidence={ECO:0000305}; Sequence=AL832192; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI16490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=DN831198; Type=Frameshift; Positions=944, 946, 960; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGB Gene

Proteomics data for ADGB Gene at MOPED

Post-translational modifications for ADGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGB Gene

Domains & Families for ADGB Gene

Gene Families for ADGB Gene

Protein Domains for ADGB Gene

Suggested Antigen Peptide Sequences for ADGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7X0

UniProtKB/Swiss-Prot:

ADGB_HUMAN :
  • Contains 1 calpain catalytic domain.
  • Belongs to the peptidase C2 family.
Domain:
  • Contains 1 calpain catalytic domain.
  • Contains 1 IQ domain.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with ADGB: view

Function for ADGB Gene

Gene Ontology (GO) - Molecular Function for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005515 protein binding IEA --
GO:0019825 oxygen binding IEA --
genes like me logo Genes that share ontologies with ADGB: view

Animal Model Products

miRNA for ADGB Gene

miRTarBase miRNAs that target ADGB

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGB Gene

Localization for ADGB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADGB Gene COMPARTMENTS Subcellular localization image for ADGB gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 3

Gene Ontology (GO) - Cellular Components for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ADGB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADGB Gene

Pathways & Interactions for ADGB Gene

SuperPathways for ADGB Gene

No Data Available

Interacting Proteins for ADGB Gene

Gene Ontology (GO) - Biological Process for ADGB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADGB Gene

Drugs & Compounds for ADGB Gene

No Compound Related Data Available

Transcripts for ADGB Gene

Unigene Clusters for ADGB Gene

Androglobin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADGB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32
SP1:
SP2: - -
SP3:
SP4:
SP5: -

Relevant External Links for ADGB Gene

GeneLoc Exon Structure for
ADGB
ECgene alternative splicing isoforms for
ADGB

Expression for ADGB Gene

mRNA expression in normal human tissues for ADGB Gene

mRNA differential expression in normal tissues according to GTEx for ADGB Gene

This gene is overexpressed in Testis (x22.5) and Fallopian Tube (x6.7).

Protein differential expression in normal tissues from HIPED for ADGB Gene

This gene is overexpressed in Blymphocyte (26.7), Plasma (18.6), CD4 Tcells (14.8), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADGB Gene



SOURCE GeneReport for Unigene cluster for ADGB Gene Hs.720870

genes like me logo Genes that share expression patterns with ADGB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADGB Gene

Orthologs for ADGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADGB 35
  • 84.96 (n)
  • 81.44 (a)
ADGB 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADGB 35
  • 85.76 (n)
  • 81.98 (a)
ADGB 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adgb 35
  • 78.16 (n)
  • 76.28 (a)
Adgb 16
Adgb 36
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC472148 35
  • 98.63 (n)
  • 97.74 (a)
ADGB 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adgb 35
  • 78.2 (n)
  • 76.14 (a)
oppossum
(Monodelphis domestica)
Mammalia ADGB 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 74 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
-- 36
  • 69 (a)
OneToMany
-- 36
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves C3H6ORF103 35
  • 61.62 (n)
  • 51.65 (a)
ADGB 36
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADGB 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adgb 35
  • 59.12 (n)
  • 51.59 (a)
zebrafish
(Danio rerio)
Actinopterygii adgb 35
  • 54.99 (n)
  • 43.92 (a)
adgb 36
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToOne
Species with no ortholog for ADGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGB Gene

ENSEMBL:
Gene Tree for ADGB (if available)
TreeFam:
Gene Tree for ADGB (if available)

Paralogs for ADGB Gene

No data available for Paralogs for ADGB Gene

Variants for ADGB Gene

Sequence variations from dbSNP and Humsavar for ADGB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9497606 - 146,672,309(+) CAAAA(C/T)AGCAG reference, missense, utr-variant-5-prime
rs1052445 - 146,815,122(+) TGGAA(A/G)CTCTG reference, missense
rs1052444 -- 146,815,076(+) CGGGA(A/T)GAGTA reference, missense
rs1052446 -- 146,815,128(+) CTCTG(G/T)CTGCT reference, missense
rs1052449 -- 146,815,308(+) GCCAA(A/C)TGAAA utr-variant-3-prime

Variation tolerance for ADGB Gene

Gene Damage Index Score: 10.76; 91.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for ADGB Gene

Disorders for ADGB Gene

Relevant External Links for ADGB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGB

No disorders were found for ADGB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGB Gene

Publications for ADGB Gene

  1. Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes. (PMID: 22115833) Hoogewijs D. … Hankeln T. (Mol. Biol. Evol. 2012) 2 3 67
  2. Androglobin knockdown inhibits growth of glioma cell lines. (PMID: 24966926) Huang B. … Hu Z.L. (Int J Clin Exp Pathol 2014) 3
  3. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PMID: 22019778) Zhang F. … Zhang X. (Nat. Genet. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3

Products for ADGB Gene

Sources for ADGB Gene

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