Free for academic non-profit institutions. Other users need a Commercial license

ADGB Gene(Protein Coding)

Androglobin

GCID:
GC06P146598
GIFtS:
39
Genes Participants
UDN Logo

Aliases for ADGB Gene

Aliases for ADGB Gene

  • Androglobin 2 3 3 5
  • Calpain-7-Like Protein 3 4
  • C6orf103 3 4
  • Chromosome 6 Open Reading Frame 103 2
  • CAPN16 3
  • CAPN7L 4

External Ids for ADGB Gene

Previous HGNC Symbols for ADGB Gene

  • C6orf103

Previous GeneCards Identifiers for ADGB Gene

  • GC06P146920

Summaries for ADGB Gene

GeneCards Summary for ADGB Gene

ADGB (Androglobin) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxygen binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGB Gene

Genomics for ADGB Gene

Products:

  1. Regulatory Element

Regulatory Elements for ADGB Gene

Enhancers for ADGB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G146770 1.1 Ensembl ENCODE 15.7 +171.9 171947 1.4 HDAC1 CBX3 CREB3L1 ZBTB40 CHAMP1 TCF12 ZNF766 ELK1 GATA2 ETV6 ADGB LOC105378040 LOC105378041
GH06G146542 1.5 FANTOM5 ENCODE 10.9 -53.6 -53620 4.8 HNRNPUL1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 KATNBL1P6 LOC101928661 ADGB RAB32 GC06M146554
GH06G146548 1.3 FANTOM5 ENCODE 10.9 -50.0 -49970 0.2 ATF1 ARNT TCF12 ZNF766 ELK1 GATA2 NCOA1 MEF2D MBD2 SMARCA4 LOC101928661 ADGB RAB32 GC06M146554
GH06G146857 1.6 Ensembl ENCODE dbSUPER 7.8 +258.9 258889 1.5 HDGF CREB3L1 AGO1 ARID4B FEZF1 DMAP1 ZNF2 ZNF766 CBX5 ZNF143 ADGB STXBP5 LOC105378042 ENSG00000272397
GH06G146912 1.8 FANTOM5 ENCODE dbSUPER 6.7 +316.0 316026 5.0 HDGF PKNOX1 CREB3L1 ARNT SIN3A FEZF1 ZNF766 FOS SP3 REST STXBP5-AS1 ADGB STXBP5 RAB32 ENSG00000272397 LOC105378042
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADGB on UCSC Golden Path with GeneCards custom track

Promoters for ADGB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000204638 36 800 HDAC1 MXI1 SAP130 SAP30 ARID4B BMI1 HBP1 E2F1 ZFHX2 EGR1

Genomic Location for ADGB Gene

Chromosome:
6
Start:
146,598,965 bp from pter
End:
146,815,462 bp from pter
Size:
216,498 bases
Orientation:
Plus strand

Genomic View for ADGB Gene

Genes around ADGB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADGB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADGB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ADGB Gene

Proteins for ADGB Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for ADGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7X0-ADGB_HUMAN
    Recommended name:
    Androglobin
    Protein Accession:
    Q8N7X0
    Secondary Accessions:
    • Q5T402
    • Q5T904
    • Q5T905

    Protein attributes for ADGB Gene

    Size:
    1667 amino acids
    Molecular mass:
    189713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AL832192; Type=Frameshift; Positions=81, 281, 581; Evidence={ECO:0000305}; Sequence=AL832192; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI16490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=DN831198; Type=Frameshift; Positions=944, 946, 960; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGB Gene

Protein Expression for ADGB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ADGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADGB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADGB Gene

Domains & Families for ADGB Gene

Gene Families for ADGB Gene

HGNC:

Protein Domains for ADGB Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ADGB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N7X0

UniProtKB/Swiss-Prot:

ADGB_HUMAN :
  • Belongs to the peptidase C2 family.
Family:
  • Belongs to the peptidase C2 family.
genes like me logo Genes that share domains with ADGB: view

Function for ADGB Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Gene Ontology (GO) - Molecular Function for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0019825 oxygen binding IEA --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with ADGB: view

Animal Model Products

miRNA for ADGB Gene

miRTarBase miRNAs that target ADGB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADGB Gene

Localization for ADGB Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADGB gene
Compartment Confidence
nucleus 4
mitochondrion 3
cytosol 3

Gene Ontology (GO) - Cellular Components for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ADGB: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADGB Gene

Pathways & Interactions for ADGB Gene

SuperPathways for ADGB Gene

PathCards logo More details on SuperPathways for ADGB
No Data Available

Interacting Proteins for ADGB Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381036%0d%0a9606.ENSP00000246533%0d%0a9606.ENSP00000265729%0d%0a9606.ENSP00000362807%0d%0a9606.ENSP00000400882%0d%0a9606.ENSP00000264933%0d%0a
Selected Interacting proteins: ENSP00000381036 for ADGB Gene via STRING

Gene Ontology (GO) - Biological Process for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA,IEA --
genes like me logo Genes that share ontologies with ADGB: view

No data available for Pathways by source and SIGNOR curated interactions for ADGB Gene

Drugs & Compounds for ADGB Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for ADGB Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for ADGB Gene

(13) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(59) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADGB Gene

Androglobin:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADGB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32
SP1:
SP2: - -
SP3:
SP4:
SP5: -

Relevant External Links for ADGB Gene

GeneLoc Exon Structure for
ADGB
ECgene alternative splicing isoforms for
ADGB

Expression for ADGB Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADGB Gene

mRNA expression in normal human tissues for ADGB Gene
mRNA expression by BioGPS for ADGB GenemRNA expression by GTEx for ADGB Gene

mRNA differential expression in normal tissues according to GTEx for ADGB Gene

This gene is overexpressed in Testis (x22.5) and Fallopian Tube (x6.7).

Protein differential expression in normal tissues from HIPED for ADGB Gene

This gene is overexpressed in Blymphocyte (26.7), Plasma (18.6), CD4 Tcells (14.8), and Breast (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADGB Gene



NURSA nuclear receptor signaling pathways regulating expression of ADGB Gene:

ADGB

SOURCE GeneReport for Unigene cluster for ADGB Gene:

Hs.720870
genes like me logo Genes that share expression patterns with ADGB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADGB Gene

Orthologs for ADGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia LOC472148 34
  • 98.63 (n)
ADGB 35
  • 98 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia ADGB 34 35
  • 85.76 (n)
cow
(Bos Taurus)
 Mammalia ADGB 34 35
  • 84.96 (n)
rat
(Rattus norvegicus)
 Mammalia Adgb 34
  • 78.2 (n)
mouse
(Mus musculus)
 Mammalia Adgb 34 16 35
  • 78.16 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 74 (a)
 OneToMany
-- 35
  • 69 (a)
 OneToMany
-- 35
  • 61 (a)
 OneToMany
-- 35
  • 58 (a)
 OneToMany
-- 35
  • 47 (a)
 OneToMany
-- 35
  • 47 (a)
 OneToMany
oppossum
(Monodelphis domestica)
 Mammalia ADGB 35
  • 57 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves C3H6ORF103 34
  • 61.62 (n)
ADGB 35
  • 48 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia ADGB 35
  • 52 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia adgb 34
  • 59.12 (n)
zebrafish
(Danio rerio)
 Actinopterygii adgb 34 35
  • 54.99 (n)
sea squirt
(Ciona savignyi)
 Ascidiacea -- 35
  • 55 (a)
 OneToOne
Species where no ortholog for ADGB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGB Gene

ENSEMBL:
Gene Tree for ADGB (if available)
TreeFam:
Gene Tree for ADGB (if available)

Paralogs for ADGB Gene

No data available for Paralogs for ADGB Gene

Variants for ADGB Gene

Sequence variations from dbSNP and Humsavar for ADGB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000004379 -- 146,640,299(+) GGGAC(A/C)TGATG intron-variant
rs1000009915 -- 146,682,260(+) TCTTA(C/T)GTATT intron-variant
rs1000026708 -- 146,776,329(+) CCTGT(A/G)AAGCT intron-variant
rs1000053788 -- 146,755,715(+) AGTCC(A/C)TTTGC intron-variant
rs1000054393 -- 146,776,065(+) TCTGG(A/G)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADGB Gene

Variant ID Type Subtype PubMed ID
dgv1022e201 CNV deletion 23290073
esv1011004 CNV deletion 20482838
esv2045633 CNV deletion 18987734
esv2159904 CNV deletion 18987734
esv2451551 CNV deletion 19546169
esv2518343 CNV deletion 19546169
esv2596411 CNV deletion 19546169
esv2665277 CNV deletion 23128226
esv2674520 CNV deletion 23128226
esv2732834 CNV deletion 23290073
esv2732835 CNV deletion 23290073
esv2732836 CNV deletion 23290073
esv2732837 CNV deletion 23290073
esv2732838 CNV deletion 23290073
esv2732839 CNV deletion 23290073
esv2762619 CNV loss 21179565
esv3422508 CNV insertion 20981092
esv3611157 CNV loss 21293372
esv3611158 CNV gain 21293372
nsv1032168 CNV loss 25217958
nsv1118001 CNV deletion 24896259
nsv349025 CNV deletion 16902084
nsv830838 CNV gain 17160897
nsv969453 CNV duplication 23825009
nsv981192 CNV duplication 23825009

Variation tolerance for ADGB Gene

Gene Damage Index Score: 10.76; 91.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADGB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADGB Gene

Disorders for ADGB Gene

Relevant External Links for ADGB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADGB

No disorders were found for ADGB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADGB Gene

Publications for ADGB Gene

  1. Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes. (PMID: 22115833) Hoogewijs D. … Hankeln T. (Mol. Biol. Evol. 2012) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  4. Androglobin knockdown inhibits growth of glioma cell lines. (PMID: 24966926) Huang B. … Hu Z.L. (Int J Clin Exp Pathol 2014) 3 64
  5. Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy. (PMID: 22019778) Zhang F. … Zhang X. (Nat. Genet. 2011) 3 64

Products for ADGB Gene

Sources for ADGB Gene

Content
Loading form....