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Aliases for ADGB Gene

Aliases for ADGB Gene

  • Androglobin 2 3
  • Calpain-7-Like Protein 3 4
  • C6orf103 3 4
  • Chromosome 6 Open Reading Frame 103 2
  • CAPN7L 4

External Ids for ADGB Gene

Previous Symbols for ADGB Gene

  • C6orf103

Summaries for ADGB Gene

GeneCards Summary for ADGB Gene

ADGB (Androglobin) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and oxygen binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADGB Gene

Genomics for ADGB Gene

Genomic Location for ADGB Gene

Start:
146,598,965 bp from pter
End:
146,815,462 bp from pter
Size:
216,498 bases
Orientation:
Plus strand

Genomic View for ADGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADGB Gene

No data available for Regulatory Elements for ADGB Gene

Proteins for ADGB Gene

  • Protein details for ADGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7X0-ADGB_HUMAN
    Recommended name:
    Androglobin
    Protein Accession:
    Q8N7X0
    Secondary Accessions:
    • Q5T402
    • Q5T904
    • Q5T905

    Protein attributes for ADGB Gene

    Size:
    1667 amino acids
    Molecular mass:
    189713 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AL832192; Type=Frameshift; Positions=81, 281, 581; Evidence={ECO:0000305}; Sequence=AL832192; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=CAI16490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI20488.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=DN831198; Type=Frameshift; Positions=944, 946, 960; Evidence={ECO:0000305};

    Alternative splice isoforms for ADGB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADGB Gene

Proteomics data for ADGB Gene at MOPED

Post-translational modifications for ADGB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADGB Gene

Domains for ADGB Gene

Protein Domains for ADGB Gene

UniProtKB/Swiss-Prot:

ADGB_HUMAN
Domain:
  • Contains 1 calpain catalytic domain.:
    • Q8N7X0
  • Contains 1 IQ domain.:
    • Q8N7X0
Family:
  • Belongs to the peptidase C2 family.:
    • Q8N7X0
genes like me logo Genes that share domains with ADGB: view

No data available for Gene Families for ADGB Gene

Function for ADGB Gene

Gene Ontology (GO) - Molecular Function for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding --
GO:0019825 oxygen binding --
GO:0020037 heme binding IEA --
genes like me logo Genes that share ontologies with ADGB: view

miRNA for ADGB Gene

miRTarBase miRNAs that target ADGB

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADGB Gene

Localization for ADGB Gene

Gene Ontology (GO) - Cellular Components for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with ADGB: view

Pathways for ADGB Gene

SuperPathways for ADGB Gene

No Data Available

Interacting Proteins for ADGB Gene

Gene Ontology (GO) - Biological Process for ADGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IBA --
GO:0015671 oxygen transport IEA --
genes like me logo Genes that share ontologies with ADGB: view

No data available for Pathways by source for ADGB Gene

Transcripts for ADGB Gene

Unigene Clusters for ADGB Gene

Androglobin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADGB Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns: 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b · 29c ^ 30 ^ 31 ^ 32
SP1:
SP2: - -
SP3:
SP4:
SP5: -

Relevant External Links for ADGB Gene

GeneLoc Exon Structure for
ADGB
ECgene alternative splicing isoforms for
ADGB

Expression for ADGB Gene

mRNA expression in normal human tissues for ADGB Gene

mRNA differential expression in normal tissues according to GTEx for ADGB Gene

This gene is overexpressed in Testis (22.5) and Fallopian Tube (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADGB Gene

SOURCE GeneReport for Unigene cluster for ADGB Gene Hs.720870

genes like me logo Genes that share expressions with ADGB: view

Orthologs for ADGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADGB 37
  • 98 (a)
OneToOne
LOC472148 36
  • 98.63 (n)
  • 97.74 (a)
cow
(Bos Taurus)
Mammalia ADGB 36
  • 84.96 (n)
  • 81.44 (a)
ADGB 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADGB 36
  • 85.76 (n)
  • 81.98 (a)
ADGB 37
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adgb 36
  • 78.16 (n)
  • 76.28 (a)
Adgb 16
Adgb 37
  • 74 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADGB 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 61 (a)
OneToMany
-- 37
  • 58 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
-- 37
  • 69 (a)
OneToMany
-- 37
  • 47 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Adgb 36
  • 78.2 (n)
  • 76.14 (a)
chicken
(Gallus gallus)
Aves ADGB 37
  • 48 (a)
OneToOne
C3H6ORF103 36
  • 61.62 (n)
  • 51.65 (a)
lizard
(Anolis carolinensis)
Reptilia ADGB 37
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adgb 36
  • 59.12 (n)
  • 51.59 (a)
zebrafish
(Danio rerio)
Actinopterygii adgb 36
  • 54.99 (n)
  • 43.92 (a)
adgb 37
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
OneToOne
Species with no ortholog for ADGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADGB Gene

ENSEMBL:
Gene Tree for ADGB (if available)
TreeFam:
Gene Tree for ADGB (if available)

Paralogs for ADGB Gene

No data available for Paralogs for ADGB Gene

Variants for ADGB Gene

Sequence variations from dbSNP and Humsavar for ADGB Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs99335 -- 146,772,037(-) GCTTA(C/T)TGAGA intron-variant
rs99337 -- 146,771,430(+) ACCAT(A/G)TTCTC intron-variant
rs99338 -- 146,771,537(+) CTCTT(A/T)GCTCA intron-variant
rs108416 -- 146,787,900(-) ATTCA(C/G)TGTTC intron-variant
rs171826 -- 146,775,311(-) TTTCA(A/G)GCCTT intron-variant

Relevant External Links for ADGB Gene

HapMap Linkage Disequilibrium report
ADGB

No data available for Structural Variations from Database of Genomic Variants (DGV) for ADGB Gene

Disorders for ADGB Gene

No disorders were found for ADGB Gene.

No data available for UniProtKB/Swiss-Prot for ADGB Gene

Publications for ADGB Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Androglobin: a chimeric globin in metazoans that is preferentially expressed in Mammalian testes. (PMID: 22115833) Hoogewijs D. … Hankeln T. (Mol. Biol. Evol. 2012) 2 3
  4. Androglobin knockdown inhibits growth of glioma cell lines. (PMID: 24966926) Huang B. … Hu Z.L. (Int J Clin Exp Pathol 2014) 3
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4

Products for ADGB Gene

Sources for ADGB Gene

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