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Aliases & Descriptions for ADFP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ADRP 1, 2, 3 | | MGC10598 2 | | OTTHUMP00000021107 2 | | adipophilin 2 |
| | | Descriptions |
|---|
| adipose differentiation-related protein 2, 3 |
|
| | Search outside databases for aliases for ADFP genePrevious GC identifers: GC09M019445 GC09M019304 GC09M019098 |
Summaries for ADFP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for ADFP: Adipocyte differentiation-related protein is associated with the globule surface membrane material. This protein is a major constituent of the globule surface. Increase in mRNA levels is one of the earliest indications of adipocyte differentiation [provided by RefSeq] UniProtKB/Swiss-Prot: ADFP_HUMAN, Q99541Function: May be involved in development and maintenance of adipose tissue (By similarity)Gene Wiki entry for ADFP |
Genomic Location for ADFP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the ADFP gene 
Entrez Gene cytogenetic band: 9p22.1 Ensembl cytogenetic band: 9p22.1 HGNC cytogenetic band: 9p22.1ADFP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M019105:
(about GC identifiers)
Start:
|
19,105,759 bp from pter |
End:
|
19,117,573 bp from pter |
Size:
|
11,815 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000009.10 NT_008413.17
| Proteins for ADFP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ADFP_HUMAN, Q99541 (See
protein sequence)Recommended Name: Adipophilin Size: 437 amino acids; 48075 Da
Subcellular location: Membrane; Peripheral membrane protein
Secondary accessions: Q9BSC3Post-translational modifications:
Acylated; primarily with C14, C16 and C18 fatty acids1
REFSEQ proteins: NP_001113.2
ENSEMBL proteins: ENSP00000369832 ENSP00000369831 ENSP00000276914
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
5/6 Gene Ontology (GO) cellular component terms (links to tree view) (see all 6
): About this table
Antibodies for ADFP: Assays for ADFP: | Protein
Domains/ Families for ADFP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q99541
ProtoNet protein and cluster: Q99541 1 Blocks protein family: IPB004279 Perilipin
UniProtKB/Swiss-Prot: ADFP_HUMAN, Q99541Similarity: Belongs to the perilipin family | Gene Function for ADFP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001122
Applied Biosystems Silencer® siRNAs for ADFP
Sigma-Aldrich siRNA for ADFP  Sigma-Aldrich shRNA for ADFP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001122                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001122                                  untagged cDNA clone in CMV expression vector: NM_001122 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001122
UniProtKB/Swiss-Prot: ADFP_HUMAN, Q99541Function: May be involved in development and maintenance of adipose tissue (By similarity)6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Adfp):
1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IEA | -- | About this table | Pathways & Interactions for ADFP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for ADFP 
5/31 Interacting proteins for ADFP (ENSP000002769143) via UniProtKB, MINT, and/or STRING (see all 31
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015909 | long-chain fatty acid transport |
IEA | -- | | GO:0019915 | lipid storage |
IEA | -- | About this table
|
Drugs & Compounds for ADFP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for ADFP 10/11 Novoseek chemical compound relationships for ADFP gene (see all 11
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lipid |
72.37 |
207 |
9392423 (8), 14707038 (6), 17872589 (6), 12804567 (5) (see all 74) |
| triacylglycerol |
61.61 |
11 |
16230742 (4), 17872589 (2), 16115879 (1) |
| oleic acid |
58.84 |
10 |
16230742 (2), 16115879 (2), 12210744 (1), 16391323 (1) (see all 5) |
| acyl-coa |
54.90 |
1 |
12893739 (1) |
| fatty acid |
46.93 |
20 |
14671211 (2), 16260216 (2), 16391323 (2), 16115879 (2) (see all 12) |
| mannose 6-phosphate |
43.27 |
1 |
17872589 (1) |
| sterol |
39.03 |
4 |
10954705 (1), 17671740 (1), 18192234 (1) |
| cholesterol |
29.86 |
17 |
17446422 (3), 14707038 (3), 11333258 (2), 10954705 (1) (see all 9) |
| prostaglandin |
10.32 |
5 |
15689536 (2), 15657374 (2) |
| arachidonic acid |
3.76 |
2 |
15689536 (1) |
About this table
|
Transcripts for ADFP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001122
Sigma-Aldrich siRNA for ADFP  Sigma-Aldrich shRNA for ADFP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001122 REFSEQ mRNAs for ADFP gene: NM_001122.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001122               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001122                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001122                                  untagged cDNA clone in CMV expression vector: NM_001122  Additional cDNA sequence: AF443203.1 AK022061.1 AK094196.1 AK296125.1 AK297920.1 AK312983.1 BC005127.2 CR536541.1 CR592339.1 CR597463.1 CR600009.1 CR600234.1 CR604128.1 CR605429.1 CR615308.1 CR618768.1 CR620358.1 CR624951.1 X97324.1 24/33 DOTS entries (see all 33
): DT.91762044 DT.117107 DT.121149566 DT.100667972 DT.121149913 DT.91673230 DT.91762036 DT.95257923 DT.100771091 DT.121149936 DT.100765283 DT.91653525 DT.99927880 DT.100054457 DT.121149922 DT.100667971 DT.121149708 DT.121149740 DT.95257919 DT.97806939 DT.100059474 DT.100642377 DT.95156312 DT.100667967 24/453 AceView cDNA sequences (see all 453
):BG576392 AI961089 BQ648372 BQ012064 BQ029253 BM905751 CR600234 AU133301 BM698704 BQ018760 BE733305 BM670795 BX108578 BI494696 BQ646820 BQ012135 BQ646549 BM999263 AA775306 BQ653092 BQ649228 BQ649403 AU121155 CR597463
highest scoring ESTs for ADFP:AA298077 AA298959 AL523948 AL531205 AL531450 AL531886 AL532099 AL553023 AL557906 AL603047 Unigene Cluster for ADFP: Adipose differentiation-related protein Hs.3416 [show with all ESTs]Unigene Representative Sequence: NM_001122
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ADFP (see all 13
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | |
| SP1: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for ADFP
3 Ensembl transcripts including schematic representations: ENST00000380465
ENST00000380464
ENST00000276914
|
Expression for ADFP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ADFP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ADFP
1 / 2 / 3 3 probe-sets matching ADFP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ATGCTTGCTT
SOURCE GeneReport for Unigene cluster: Hs.3416
Expression variation in blood from EXPOLDB for ADFP UniProtKB/Swiss-Prot: ADFP_HUMAN, Q99541Tissue specificity: Milk lipid globules |
Orthologs for ADFP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ADFP gene from 5/10 species (see all 10
)
About this table Species with no ortholog for ADFP
ENSEMBL Gene Tree for ADFP | Paralogs for ADFP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for ADFP gene
- LSDP52 PLIN2 M6PRBP12
Pseudogenes
- 1 related pseudogene
|
SNPs/Variants for ADFP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ADFP (up to first 250kb)
|
Disorders & Mutations for ADFP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 103195
8 Novoseek disease relationships for ADFP gene
About this table
|
Medical News for ADFP(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for ADFP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/131 PubMed articles for ADFP gene (see all 131
):- Adipocyte differentiation-related protein is secreted into milk as a constituent of milk lipid globule membrane. (PubMed id 9003395)1, 2, 3, 4 Heid H.W.... Keenan T.W. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- PPARalpha activators and fasting induce the expression of adipose differentiation-related protein in liver. (PubMed id 16489205)1, 3 Dalen K.T....Nebb H.I. (2006)
- ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells. (PubMed id 16230742)1, 3 Masuda Y....Takano T. (2006)
- Adipophilin expression is increased in symptomatic carotid atherosclerosis: correlation with red blood cells and cholesterol crystals. (PubMed id 17446422)1, 3 Nuotio K....Lindsberg P.J. (2007)
- Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line. (PubMed id 16391323)1, 3 Tobin K.A....Duttaroy A.K. (2006)
- Adipophilin increases triglyceride storage in human macrophages by stimulation of biosynthesis and inhibition of beta-oxidation. (PubMed id 16884492)1, 3 Larigauderie G....Rouis M. (2006)
- Adipophilin enhances lipid accumulation and prevents lipid efflux from THP-1 macrophages: potential role in atherogenesis. (PubMed id 14707038)1, 3 Larigauderie G....Rouis M. (2004)
- The lipid droplet-associated protein adipophilin is expressed in human trophoblasts and is regulated by peroxisomal proliferator-activated receptor-gamma/retinoid X receptor. (PubMed id 14671211)1, 3 Bildirici I....Sadovsky Y. (2003)
- Adipophilin is a specific marker of lipid accumulation in diverse cell types and diseases. (PubMed id 9799447)1, 3 Heid H.W....Keenan T.W. (1998)
|
Search for ADFP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ADFP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ADFP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADFP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for ADFP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for ADFP:

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Incremental update: 13 Oct 2009
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