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ADD3 Gene

protein-coding   GIFtS: 61
GCID: GC10P111755

Adducin 3 (Gamma)


(Previous symbol: ADDL)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adducin 3 (Gamma)1 2
ADDL1 2 3 5
Adducin-Like Protein 702 3
gamma-adducin2

External Ids:    HGNC: 2451   Entrez Gene: 1202   Ensembl: ENSG000001487007   OMIM: 6015685   UniProtKB: Q9UEY83   

Export aliases for ADD3 gene to outside databases

Previous GC identifers: GC10P110658 GC10P111094 GC10P111897 GC10P111430 GC10P111432 GC10P105396


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADD3 Gene:
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The
three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the
assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While
adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and
hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of
adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been
associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of
alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct
domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region
is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site
for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma
transcripts encoding different isoforms have been described. The functions of the different isoforms are not
known. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADD3 Gene:
ADD3 (adducin 3 (gamma)) is a protein-coding gene. Diseases associated with ADD3 include cerebral palsy, spastic quadriplegic, 1, and dyscalculia. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ADD1.

UniProtKB/Swiss-Prot: ADDG_HUMAN, Q9UEY8
Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds
to calmodulin

Gene Wiki entry for ADD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NT_030059.14  NC_018921.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADD3 gene promoter:
         Oct-B1   oct-B2   POU2F1   oct-B3   POU2F1a   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADD3 promoter sequence
   Search Chromatin IP Primers for ADD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q25.2   Ensembl cytogenetic band:  10q25.1   HGNC cytogenetic band: 10q25.2

ADD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADD3 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P111755:  view genomic region     (about GC identifiers)

Start:
111,756,126 bp from pter      End:
111,895,323 bp from pter
Size:
139,198 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADDG_HUMAN, Q9UEY8 (See protein sequence)
Recommended Name: Gamma-adducin  
Size: 706 amino acids; 79155 Da
Subunit: Heterodimer of an alpha and a gamma subunit
Secondary accessions: D3DRA8 O43243 Q5VU09 Q92773 Q9UEY7
Alternative splicing: 2 isoforms:  Q9UEY8-1   Q9UEY8-2   

Explore the universe of human proteins at neXtProt for ADD3: NX_Q9UEY8

Explore proteomics data for ADD3 at MOPED

Post-translational modifications: 

  • Sumoylated1
  • Ubiquitination2 at Lys21, Lys401, Lys448
  • Modification sites at PhosphoSitePlus

  • See ADD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001112.2  NP_058432.1  NP_063968.1  

    ENSEMBL proteins: 
     ENSP00000353286   ENSP00000348381   ENSP00000277900  

    ADD3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ADD3
    OriGene Protein Over-expression Lysate for ADD3
    OriGene MassSpec for ADD3
    OriGene Custom Protein Services for ADD3
    GenScript Custom Purified and Recombinant Proteins Services for ADD3
    Novus Biologicals ADD3 Protein
    Novus Biologicals ADD3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADD3

    ADD3 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ADD3
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ADD3
    OriGene Custom Antibody Services for ADD3
    Novus Biologicals ADD3 Antibodies
    Abcam antibodies for ADD3
    Cloud-Clone Corp. Antibodies for ADD3
    Search ThermoFisher Antibodies for ADD3
    LSBio Antibodies in human, mouse, rat for ADD3

    ADD3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADD3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADD3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADD3
    Cloud-Clone Corp. CLIAs for ADD3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027772 ADD3
     IPR001303 Aldolase_II/adducin_N

    Graphical View of Domain Structure for InterPro Entry Q9UEY8

    ProtoNet protein and cluster: Q9UEY8

    1 Blocks protein domain: IPB001303 Class II aldolase/adducin

    UniProtKB/Swiss-Prot: ADDG_HUMAN, Q9UEY8
    Domain: Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting
    subdomain, and a protease-sensitive tail region
    Similarity: Belongs to the aldolase class II family. Adducin subfamily


    ADD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADDG_HUMAN, Q9UEY8
    Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds
    to calmodulin

         Genatlas biochemistry entry for ADD3:
    adducin 3,actin accessory protein,calmodulin binding,ubiquitously expressed

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005198structural molecule activity ----
    GO:0005200structural constituent of cytoskeleton TAS8893809
    GO:0005516calmodulin binding IEA--
         
    ADD3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADD3:
     Decreased focal adhesion (FA)  

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Add3):
     cardiovascular system  hematopoietic system  no phenotypic analysis  normal 

    ADD3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Add3tm1.2Llp for ADD3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADD3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADD3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADD3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADD3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADD3:
    hsa-mir-24-3p (MIRT030536), hsa-mir-374b-5p (MIRT016076), hsa-mir-124-3p (MIRT022859)

    Block miRNA regulation of human, mouse, rat ADD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADD3 (see all 41):
    hsa-miR-579 hsa-miR-429 hsa-miR-1197 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-200a hsa-miR-605 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidADD3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADD3
    Predesigned siRNA for gene silencing in human, mouse, rat ADD3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADD3

    Clone
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    OriGene clones in human, mouse for ADD3 (see all 20)
    OriGene ORF clones in mouse, rat for ADD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ADD3 (NM_016824)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADD3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ADD3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADD3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADDG_HUMAN, Q9UEY8: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    plasma membrane5
    cytosol3
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000794condensed nuclear chromosome IEA--
    GO:0005737cytoplasm ----
    GO:0005856cytoskeleton IEA--
    GO:0005886plasma membrane IEA--
    GO:0005911cell-cell junction IEA--

    ADD3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADD3 About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of cAMP-Dependent PKA
    Activation of cAMP-Dependent PKA0.77
    Activation of PKA through GPCR0.71
    cAMP Pathway0.77
    PKA Signaling0.56

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADD3
        Activation of PKA through GPCR
    PKA Signaling
    cAMP Pathway
    Activation of cAMP-Dependent PKA


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADD3
    Interactions:

        GeneGlobe Interaction Network for ADD3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for ADD3 (Q9UEY83 ENSP000003483814) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCAP172523, ENSP000002843844I2D: score=2 STRING: ENSP00000284384
    HIRAP541983I2D: score=1 
    YWHABP319463I2D: score=1 
    LIN7AENSP000002612034STRING: ENSP00000261203
    LIN7BENSP000002214594STRING: ENSP00000221459
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADD3 (ADDG)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADD3 gene (3 alternative transcripts): 
    NM_001121.2  NM_016824.3  NM_019903.3  

    Unigene Cluster for ADD3:

    Adducin 3 (gamma)
    Hs.501012  [show with all ESTs]
    Unigene Representative Sequence: NM_016824
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000468251 ENST00000360162 ENST00000356080 ENST00000277900(uc001kyt.4 uc001kys.4 uc001kyu.3 uc001kyv.3 uc001kyw.3 uc001kyx.3)
    ENST00000487085 ENST00000484622 ENST00000459738 ENST00000495661 ENST00000497125
    ENST00000475954 ENST00000496517 ENST00000473669 ENST00000468345 ENST00000486014
    ENST00000488104 ENST00000488837 ENST00000472568 ENST00000492162

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADD3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADD3 (see all 41):
    hsa-miR-579 hsa-miR-429 hsa-miR-1197 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-200a hsa-miR-605 hsa-miR-374c
    SwitchGear 3'UTR luciferase reporter plasmidADD3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADD3
    Predesigned siRNA for gene silencing in human, mouse, rat ADD3
    Clone
    Products:
         
    OriGene clones in human, mouse for ADD3 (see all 20)
    OriGene ORF clones in mouse, rat for ADD3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ADD3 (NM_016824)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADD3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADD3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADD3
    OriGene qSTAR qPCR primer pairs in human, mouse for ADD3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADD3
      QuantiTect SYBR Green Assays in human, mouse, rat ADD3
      QuantiFast Probe-based Assays in human, mouse, rat ADD3

    Additional mRNA sequence: 

    AB209810.1 AK223270.1 AK291488.1 BC021694.1 BC043143.1 BC057285.1 BC062559.1 BX647403.1 
    BX647442.1 BX648016.1 D67031.1 EF553523.1 U37122.1 

    Selected DOTS entries (see all 44):

    DT.100672560  DT.118663  DT.95351696  DT.80101994  DT.100678183  DT.95141368  DT.121244201  DT.95351635 
    DT.95142477  DT.121244053  DT.86855570  DT.75121299  DT.97803197  DT.97768609  DT.95351634  DT.101985158 
    DT.121244068  DT.95351701  DT.121244301  DT.95175555  DT.95351685  DT.92446183  DT.95351636  DT.121244085 

    Selected AceView cDNA sequences (see all 565):

    BM875698 BI769647 AA436059 BQ006529 BG576985 CB156165 AI702285 AV696958 
    CA945148 CB267486 AI348233 AA442161 AA359304 CB156137 H89163 BU735612 
    CD678626 BU787760 BU740039 AI200096 CB305928 BQ019413 BQ575118 AI754317 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADD3 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ·
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -                 -                                       
    SP2:                                                  -     -     -     -     -     -     -     -     -                 -                                       
    SP3:                                                                                                                    -                                       
    SP4:                                                  -     -     -     -     -     -     -     -     -                 -                                       
    SP5:                                                  -     -     -     -     -     -     -     -     -                                                         

    ExUns: 14d · 14e · 14f ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b
    SP1:                                                                                      -                                         -               
    SP2:                                                                                      -                                         -               
    SP3:                                                                                      -                                         -               
    SP4:                                                                                      -                                   -     -               
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for ADD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAAAAATTA
    ADD3 Expression
    About this image


    ADD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    ADD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.501012

    UniProtKB/Swiss-Prot: ADDG_HUMAN, Q9UEY8
    Tissue specificity: Isoform 1 is ubiquitously expressed

        Custom PCR Arrays for ADD3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADD3
    QuantiTect SYBR Green Assays in human, mouse, rat ADD3
    QuantiFast Probe-based Assays in human, mouse, rat ADD3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADD3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Add31 , 5 adducin 3 (gamma)1, 5 86.92(n)1
    92.21(a)1
      19 (47.18 cM)5
    273601  NM_013758.41  NP_038786.21 
     531404455 
    chicken
    (Gallus gallus)
    Aves ADD31 adducin 3 (gamma) 79.31(n)
    85.94(a)
      373892  NM_204103.1  NP_989434.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADD36
    adducin 3 (gamma)
    83(a)
    1 ↔ 1
    3(44823727-44977299)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.59192 Transcribed sequence with moderate similarity to protein more 74.72(n)    BX727175.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc16e062 wufc16e06 73.3(n)   324001  BC045384.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta hts3 ring canal formation, actin assembly
    actin binding
    36(a)   56D3   --
    worm
    (Caenorhabditis elegans)
    Secernentea add-23 adducin 45(a)   V(12012251-12016002)   --


    ENSEMBL Gene Tree for ADD3 (if available)
    TreeFam Gene Tree for ADD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADD3 gene
    ADD12  ADD22  
    2 SIMAP similar genes for ADD3 using alignment to 2 protein entries:     ADDG_HUMAN (see all proteins):
    ADD2    ADD1

    ADD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADD3 (see all 2570)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs741549391,2
    C,F--105394714(+) TTGGGG/AGCAAT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1922143111,2
    --111770150(+) GAAATC/TACATA 3 -- int10--------
    rs1177906141,2
    F--111770233(+) ACCGAG/ATTGTT 3 -- int11Minor allele frequency- A:0.02EA 120
    rs1827830651,2
    C--111770260(+) GAATGA/GGGTTT 3 -- int10--------
    rs1870699281,2
    --111770382(+) AGCCAA/GTATTT 3 -- int10--------
    rs1915110191,2
    --111770463(+) CAGTGG/TCTAAA 3 -- int10--------
    rs1848779481,2
    --111770626(+) ATTCCC/GACGAC 3 -- int10--------
    rs1893389811,2
    --111770669(+) CTCTGA/GTATTA 3 -- int10--------
    rs795469331,2
    F--111770671(+) CTGGTA/GTTAAT 3 -- int11Minor allele frequency- G:0.01WA 118
    rs1926674591,2
    --111770719(+) AATCCA/GCATTA 3 -- int10--------

    HapMap Linkage Disequilibrium report for ADD3 (111756126 - 111895323 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676886CNV Deletion23128226
    esv2501162CNV Deletion19546169
    nsv7547CNV Loss18451855
    nsv7211OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADD3
    DNA2.0 Custom Variant and Variant Library Synthesis for ADD3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601568    OMIM disorders: --

    Selected diseases for ADD3 (see all 23):    
    About MalaCards
    cerebral palsy, spastic quadriplegic, 1    dyscalculia    endolymphatic hydrops    twin twin transfusion syndrome
    twin-to-twin transfusion syndrome    hereditary elliptocytosis    diffuse astrocytoma    hypertension
    biliary atresia    was-related disorders    astrocytoma    essential hypertension
    lymphoblastic leukemia    tonsillitis    alzheimer's disease    leukemia
    lung cancer    hepatitis    thyroiditis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for ADD3:
    Dyscalculia

    ADD3 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): ADD3
    Human Genome Epidemiology (HuGE) Navigator: ADD3 (11 documents)

    Export disorders for ADD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADD3 gene, integrated from 10 sources (see all 57):
    (articles sorted by number of sources associating them with ADD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin. (PubMed id 8893809)1, 2, 3, 9 Katagiri T.... Hirai Y. (Cytogenet. Cell Genet. 1996)
    2. Role of the adducin family genes in human essential hypertension. (PubMed id 15716695)1, 4, 9 Lanzani C....Manunta P. (J. Hypertens. 2005)
    3. Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans. (PubMed id 15834281)1, 4, 9 Cwynar M....Bianchi G. (J. Hypertens. 2005)
    4. Genomic organization of the human gamma adducin gene. (PubMed id 10581174)1, 2, 9 Citterio L.... Bianchi G. (Biochem. Biophys. Res. Commun. 1999)
    5. Arterial properties in relation to genetic variations in the adducin subunits in a white population. (PubMed id 18787518)1, 4, 9 SeidlerovA! J....Bianchi G. (Am. J. Hypertens. 2009)
    6. Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population. (PubMed id 18475162)1, 4, 9 Kuznetsova T....Staessen J.A. (J. Hypertens. 2008)
    7. Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in MAcniA"re's syndrome. (PubMed id 18667944)1, 4, 9 Teggi R....Bussi M. (amp 2008)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 120 HGNC: 245 AceView: ADD3 Ensembl:ENSG00000148700 euGenes: HUgn120
    ECgene: ADD3 H-InvDB: ADD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADD3 gene:
    Search GeneIP for patents involving ADD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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