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Aliases for ADD3 Gene

Aliases for ADD3 Gene

  • Adducin 3 (Gamma) 2 3
  • ADDL 3 4 6
  • Adducin-Like Protein 70 3 4
  • Gamma-Adducin 3

External Ids for ADD3 Gene

Previous HGNC Symbols for ADD3 Gene

  • ADDL

Previous GeneCards Identifiers for ADD3 Gene

  • GC10P110658
  • GC10P111094
  • GC10P111897
  • GC10P111430
  • GC10P111432
  • GC10P111755
  • GC10P105396

Summaries for ADD3 Gene

Entrez Gene Summary for ADD3 Gene

  • Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADD3 Gene

ADD3 (Adducin 3 (Gamma)) is a Protein Coding gene. Diseases associated with ADD3 include inherited congenital spastic tetraplegia and dyscalculia. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include actin binding and structural constituent of cytoskeleton. An important paralog of this gene is ADD2.

UniProtKB/Swiss-Prot for ADD3 Gene

  • Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin

Gene Wiki entry for ADD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADD3 Gene

Genomics for ADD3 Gene

Regulatory Elements for ADD3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADD3 Gene

Start:
109,996,368 bp from pter
End:
110,135,565 bp from pter
Size:
139,198 bases
Orientation:
Plus strand

Genomic View for ADD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADD3 Gene

Proteins for ADD3 Gene

  • Protein details for ADD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UEY8-ADDG_HUMAN
    Recommended name:
    Gamma-adducin
    Protein Accession:
    Q9UEY8
    Secondary Accessions:
    • D3DRA8
    • O43243
    • Q5VU09
    • Q92773
    • Q9UEY7

    Protein attributes for ADD3 Gene

    Size:
    706 amino acids
    Molecular mass:
    79155 Da
    Quaternary structure:
    • Heterodimer of an alpha and a gamma subunit

    Alternative splice isoforms for ADD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADD3 Gene

Proteomics data for ADD3 Gene at MOPED

Post-translational modifications for ADD3 Gene

Other Protein References for ADD3 Gene

Antibody Products

No data available for DME Specific Peptides for ADD3 Gene

Domains for ADD3 Gene

Protein Domains for ADD3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UEY8

UniProtKB/Swiss-Prot:

ADDG_HUMAN :
  • Q9UEY8
Domain:
  • Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region
Family:
  • Belongs to the aldolase class II family. Adducin subfamily.
genes like me logo Genes that share domains with ADD3: view

No data available for Gene Families for ADD3 Gene

Function for ADD3 Gene

Molecular function for ADD3 Gene

GENATLAS Biochemistry: adducin 3,actin accessory protein,calmodulin binding,ubiquitously expressed
UniProtKB/Swiss-Prot Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin

Gene Ontology (GO) - Molecular Function for ADD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005198 structural molecule activity --
GO:0005200 structural constituent of cytoskeleton TAS 8893809
GO:0005516 calmodulin binding IEA --
genes like me logo Genes that share ontologies with ADD3: view

Phenotypes for ADD3 Gene

genes like me logo Genes that share phenotypes with ADD3: view

Animal Models for ADD3 Gene

MGI Knock Outs for ADD3:

Animal Model Products

miRNA for ADD3 Gene

miRTarBase miRNAs that target ADD3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADD3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADD3 Gene

Localization for ADD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADD3 Gene

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADD3 Gene COMPARTMENTS Subcellular localization image for ADD3 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ADD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000794 condensed nuclear chromosome IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ADD3: view

Pathways for ADD3 Gene

genes like me logo Genes that share pathways with ADD3: view

Pathways by source for ADD3 Gene

Interacting Proteins for ADD3 Gene

Gene Ontology (GO) - Biological Process for ADD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with ADD3: view

Transcripts for ADD3 Gene

Unigene Clusters for ADD3 Gene

Adducin 3 (gamma):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADD3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADD3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b · 14c ·
SP1: - - - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: -
SP4: - - - - - - - - - -
SP5: - - - - - - - - -
SP6:
SP7: - - - - - - - - - - - - - -
SP8: - - - - - - - - - - - - -
SP9: - - - - - - - - - - - - -
SP10: - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - -
SP13: - -
SP14: - - -
SP15:
SP16: - - - - - -
SP17: - - - - - - - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - - - - - - - -
SP20: - - - - - - - - - - - - -
SP21: - - - - - - -
SP22: - - - - -
SP23: - - -
SP24: - - - -
SP25: -

ExUns: 14d · 14e · 14f ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c · 16d ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25a · 25b
SP1: - -
SP2: - -
SP3: - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12: - - -
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19: - - - - - - -
SP20: - - -
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for ADD3 Gene

GeneLoc Exon Structure for
ADD3
ECgene alternative splicing isoforms for
ADD3

Expression for ADD3 Gene

mRNA expression in normal human tissues for ADD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADD3 Gene

SOURCE GeneReport for Unigene cluster for ADD3 Gene Hs.501012

mRNA Expression by UniProt/SwissProt for ADD3 Gene

Q9UEY8-ADDG_HUMAN
Tissue specificity: Isoform 1 is ubiquitously expressed.
genes like me logo Genes that share expressions with ADD3: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADD3 Gene

Orthologs for ADD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADD3 35
  • 99.76 (n)
  • 99.72 (a)
ADD3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADD3 35
  • 92.43 (n)
  • 95.99 (a)
ADD3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADD3 35
  • 93.01 (n)
  • 96.74 (a)
ADD3 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Add3 35
  • 86.92 (n)
  • 92.21 (a)
Add3 16
Add3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADD3 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADD3 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Add3 35
  • 87.14 (n)
  • 93.05 (a)
chicken
(Gallus gallus)
Aves ADD3 35
  • 79.31 (n)
  • 85.94 (a)
ADD3 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADD3 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia add3 35
  • 67.4 (n)
  • 72.62 (a)
Str.5919 35
zebrafish
(Danio rerio)
Actinopterygii add3a 35
  • 67.16 (n)
  • 71.13 (a)
add3a 36
  • 71 (a)
OneToMany
add3b 36
  • 51 (a)
OneToMany
wufc16e06 35
fruit fly
(Drosophila melanogaster)
Insecta hts 36
  • 14 (a)
OneToMany
hts 37
  • 36 (a)
worm
(Caenorhabditis elegans)
Secernentea add-1 36
  • 29 (a)
ManyToMany
add-2 36
  • 26 (a)
ManyToMany
add-2 37
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8742 36
  • 36 (a)
ManyToMany
Species with no ortholog for ADD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADD3 Gene

ENSEMBL:
Gene Tree for ADD3 (if available)
TreeFam:
Gene Tree for ADD3 (if available)

Paralogs for ADD3 Gene

Paralogs for ADD3 Gene

Selected SIMAP similar genes for ADD3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADD3: view

Variants for ADD3 Gene

Sequence variations from dbSNP and Humsavar for ADD3 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs5786 -- 110,133,667(+) ACATC(C/T)AAATA utr-variant-3-prime
rs8138 -- 110,134,192(+) TGAAG(C/T)AACTT utr-variant-3-prime
rs14481 -- 110,135,525(-) TAATT(A/G)GCATT utr-variant-3-prime
rs15947 -- 110,130,428(-) CCTTC(C/T)GTGAG reference, synonymous-codon
rs867975 -- 110,074,821(+) CAAGC(C/T)CATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADD3 Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv7547 CNV Loss 18451855
esv2676886 CNV Deletion 23128226
esv2501162 CNV Deletion 19546169

Relevant External Links for ADD3 Gene

HapMap Linkage Disequilibrium report
ADD3
Human Gene Mutation Database (HGMD)
ADD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADD3 Gene

Disorders for ADD3 Gene

(1) University of Copenhagen DISEASES for ADD3 Gene

Relevant External Links for ADD3

Genetic Association Database (GAD)
ADD3
Human Genome Epidemiology (HuGE) Navigator
ADD3
genes like me logo Genes that share disorders with ADD3: view

No data available for UniProtKB/Swiss-Prot for ADD3 Gene

Publications for ADD3 Gene

  1. Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin. (PMID: 8893809) Katagiri T. … Hirai Y. (Cytogenet. Cell Genet. 1996) 2 3 4 23
  2. Genomic organization of the human gamma adducin gene. (PMID: 10581174) Citterio L. … Bianchi G. (Biochem. Biophys. Res. Commun. 1999) 3 4 23
  3. Role of the adducin family genes in human essential hypertension. (PMID: 15716695) Lanzani C. … Manunta P. (J. Hypertens. 2005) 3 23 48
  4. Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans. (PMID: 15834281) Cwynar M. … Bianchi G. (J. Hypertens. 2005) 3 23 48
  5. Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population. (PMID: 18475162) Kuznetsova T. … Staessen J.A. (J. Hypertens. 2008) 3 23 48

Products for ADD3 Gene

Sources for ADD3 Gene

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