Aliases for ADD2 Gene
Aliases for ADD2 Gene
External Ids for ADD2 Gene
- HGNC: 244
- Entrez Gene: 119
- Ensembl: ENSG00000075340
- OMIM: 102681
- UniProtKB: P35612
Previous GeneCards Identifiers for ADD2 Gene
- GC02M070898
- GC02M071100
- GC02M070863
- GC02M070800
Summaries for ADD2 Gene
-
Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
GeneCards Summary for ADD2 Gene
ADD2 (Adducin 2) is a Protein Coding gene. Diseases associated with ADD2 include Capillariasis and Echolalia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Aquaporin-mediated transport. GO annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is ADD3.
UniProtKB/Swiss-Prot for ADD2 Gene
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADD2 Gene
Genomics for ADD2 Gene
Regulatory Elements for ADD2 Gene
Enhancers for ADD2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH02G070732 | 0.6 | ENCODE | 33.8 | +34.5 | 34499 | 2.6 | CTCF RFX1 POLR2A SMARCA4 TEAD4 RBBP5 REST | ADD2 FIGLA PIR38094 |
| GH02G070522 | 1.5 | Ensembl ENCODE dbSUPER | 9.9 | +243.4 | 243437 | 4.0 | FOXA2 PKNOX1 ARNT SIN3A FOS DEK ZNF263 SP3 REST PPARG | TGFA ADD2 ASPRV1 TGFA-IT1 |
| GH02G070727 | 0.7 | ENCODE | 19.2 | +39.6 | 39638 | 1.3 | ESRRA ZFP64 ZNF140 ZNF101 ZNF697 ZNF791 POLR2A ZNF433 EGR2 ZNF426 | MPHOSPH10 ADD2 ANKRD53 LOC105374796 PIR38094 |
| GH02G070540 | 1.4 | Ensembl ENCODE dbSUPER | 9.4 | +226.5 | 226528 | 2.2 | SIN3A ZNF2 GLIS2 FOS REST ZNF592 MBD2 HMBOX1 KDM1A SP7 | MPHOSPH10 ADD2 TGFA TGFA-IT1 |
| GH02G070619 | 1 | FANTOM5 ENCODE dbSUPER | 11.6 | +148.1 | 148122 | 0.9 | POLR2A PRDM1 | ADD2 TGFA FIGLA GC02M070656 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ADD2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ADD2 gene promoter:
Regulatory Element Products
Genomic Location for ADD2 Gene
- Chromosome:
- 2
- Start:
- 70,607,618 bp from pter
- End:
- 70,768,243 bp from pter
- Size:
- 160,626 bases
- Orientation:
- Minus strand
Genomic View for ADD2 Gene
Genes around ADD2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p13.3 by Ensembl
- 2p13.3 by Entrez Gene
- 2p13.3 by HGNC
ADD2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADD2 Gene
Proteins for ADD2 Gene
-
Protein details for ADD2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35612-ADDB_HUMAN
- Recommended name:
- Beta-adducin
- Protein Accession:
- P35612
- A8K4P2
- B4DM17
- D6W5G7
- D6W5G8
- Q13482
- Q16412
- Q59G82
- Q5U5P4
- Q6P0P2
- Q6PGQ4
- Q7Z688
- Q7Z689
- Q7Z690
- Q7Z691
Protein attributes for ADD2 Gene
- Size:
- 726 amino acids
- Molecular mass:
- 80854 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit. Found in a complex with ADD2, DMTN and SLC2A1. Interacts with SLC2A1.
- SequenceCaution:
-
- Sequence=BAD92464.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ADD2 Gene
Post-translational modifications for ADD2 Gene
- The N-terminus is blocked.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for ADD2 Gene
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ADD2
- Novus Biologicals Antibodies for ADD2
- Invitrogen Antibodies for ADD2
- antibodies-online Antibodies for ADD2: See all 51
- GeneTex ADD2 antibody for ADD2
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADD2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ADD2
- Origene Custom Protein Services for ADD2
- antibodies-online Proteins for ADD2: See all 8
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ADD2
Assay Products
- antibodies-online Kits for ADD2: See all 7
No data available for DME Specific Peptides for ADD2 Gene
Domains & Families for ADD2 Gene
Protein Domains for ADD2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADD2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35612UniProtKB/Swiss-Prot:
ADDB_HUMAN :- Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
- Belongs to the aldolase class II family. Adducin subfamily.
- Domain:
-
- Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
- Family:
-
- Belongs to the aldolase class II family. Adducin subfamily.
No data available for Gene Families for ADD2 Gene
Function for ADD2 Gene
Molecular function for ADD2 Gene
- GENATLAS Biochemistry:
- adducin beta,actin accessory protein,calmodulin binding protein,97kDa,component of the erythrocyte membrane skeleton,also expressed in brain,kidney,liver,intestine,leukocytes,platelets
- UniProtKB/Swiss-Prot Function:
- Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to the erythrocyte membrane receptor SLC2A1/GLUT1 and may therefore provide a link between the spectrin cytoskeleton to the plasma membrane. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003779 | actin binding | IMP | 25425738 |
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005516 | calmodulin binding | IEA | -- |
| GO:0019901 | protein kinase binding | IPI | 25425738 |
| GO:0030507 | spectrin binding | IDA | 7642559 |
Phenotypes for ADD2 Gene
- MGI mutant phenotypes for ADD2:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ADD2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADD2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADD2 gene
- Search ViGene Biosciences for ADD2
CRISPR Products
-
OriGene CRISPR knockouts for ADD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADD2
- GenScript: Design CRISPR guide RNA sequences for ADD2
miRNA for ADD2 Gene
- miRTarBase miRNAs that target ADD2
-
- hsa-mir-1301-3p (MIRT035978)
- hsa-mir-107 (MIRT048288)
- hsa-mir-6825-5p (MIRT490824)
- hsa-mir-7106-5p (MIRT490826)
- hsa-mir-6797-5p (MIRT490827)
- hsa-mir-1249-5p (MIRT490828)
- hsa-mir-650 (MIRT490829)
- hsa-mir-765 (MIRT490830)
- hsa-mir-3612 (MIRT490831)
- hsa-mir-4644 (MIRT490832)
- hsa-mir-4306 (MIRT490833)
- hsa-mir-185-5p (MIRT490834)
- hsa-mir-4722-5p (MIRT490835)
- hsa-mir-6130 (MIRT490836)
- hsa-mir-6133 (MIRT490837)
- hsa-mir-6129 (MIRT490838)
- hsa-mir-6127 (MIRT490839)
- hsa-mir-4510 (MIRT490840)
- hsa-mir-4419a (MIRT490841)
- hsa-mir-1827 (MIRT490842)
- hsa-mir-3150b-3p (MIRT490843)
- hsa-mir-4784 (MIRT490844)
- hsa-mir-4459 (MIRT490845)
- hsa-mir-940 (MIRT490846)
- hsa-mir-6893-5p (MIRT490847)
- hsa-mir-4779 (MIRT490848)
- hsa-mir-6808-5p (MIRT490849)
- hsa-mir-4695-5p (MIRT490850)
- hsa-mir-6856-5p (MIRT490851)
- hsa-mir-6758-5p (MIRT490852)
- hsa-mir-4762-3p (MIRT539406)
- hsa-mir-384 (MIRT539407)
- hsa-mir-3685 (MIRT539408)
- hsa-mir-3192-3p (MIRT539409)
- hsa-mir-1290 (MIRT539410)
- hsa-mir-3151-3p (MIRT539411)
- hsa-mir-5009-3p (MIRT539412)
- hsa-mir-190a-3p (MIRT708213)
- hsa-mir-374b-5p (MIRT708214)
- hsa-mir-374a-5p (MIRT708215)
- hsa-mir-223-5p (MIRT708216)
- hsa-mir-511-3p (MIRT708217)
- hsa-mir-5011-5p (MIRT708218)
- hsa-mir-5692c (MIRT708219)
- hsa-mir-5692b (MIRT708220)
- hsa-mir-369-3p (MIRT708221)
- hsa-mir-3163 (MIRT708222)
- hsa-mir-5583-3p (MIRT708223)
- hsa-mir-4517 (MIRT708224)
- hsa-mir-1277-5p (MIRT708225)
- hsa-mir-410-3p (MIRT708226)
miRNA Products
- Search ViGene Biosciences for ADD2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ADD2
- Browse OriGene Inhibitory RNA Products For ADD2
-
ViGene Biosciences ready-to-package AAV shRNAs for ADD2 gene
Clone Products
-
OriGene ORF clones in human for ADD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADD2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ADD2
-
ViGene Biosciences adenoviral particle packaged cDNA for ADD2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADD2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADD2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADD2 Gene
Localization for ADD2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADD2 Gene
- Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| cytosol | 5 |
| nucleus | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0008290 | F-actin capping protein complex | IDA | 8626479 |
Pathways & Interactions for ADD2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | Miscellaneous transport and binding events | ||
| 3 | Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | ||
| 4 | Aquaporin-mediated transport | ||
Pathways by source for ADD2 Gene
2 Reactome pathways for ADD2 Gene
1 GeneGo (Thomson Reuters) pathway for ADD2 Gene
4 Qiagen pathways for ADD2 Gene
Interacting Proteins for ADD2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006461 | protein complex assembly | IDA | 18347014 |
| GO:0030036 | actin cytoskeleton organization | IC | 3693401 |
| GO:0030097 | hemopoiesis | IEA | -- |
| GO:0032092 | positive regulation of protein binding | IDA | 3693401 |
| GO:0050900 | leukocyte migration | IMP | 25425738 |
Transcripts for ADD2 Gene
mRNA/cDNA for ADD2 Gene
- (11) REFSEQ mRNAs :
- (19) Additional mRNA sequences :
- (173) Selected AceView cDNA sequences:
- (14) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ADD2
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADD2
- GenScript: Design CRISPR guide RNA sequences for ADD2
miRNA Products
- Search ViGene Biosciences for ADD2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ADD2
- Browse OriGene Inhibitory RNA Products For ADD2
-
ViGene Biosciences ready-to-package AAV shRNAs for ADD2 gene
Clone Products
-
OriGene ORF clones in human for ADD2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADD2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADD2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | · | 9e | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | - | - | - | - |
| ExUns: | 18 | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23a | · | 23b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | |||||||||||||
| SP3: | - | - | |||||||||||||
| SP4: | |||||||||||||||
| SP5: | |||||||||||||||
| SP6: | |||||||||||||||
| SP7: | |||||||||||||||
| SP8: | |||||||||||||||
| SP9: | |||||||||||||||
| SP10: | |||||||||||||||
| SP11: |
Expression for ADD2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Cerebellum
- Medulla Oblongata
- Cerebral Cortex
-
Blood (Hematopoietic System)
- Proerythroblasts Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Inner Cell Mass (Early Embryonic Tissues)
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
-
Heart (Cardiovascular System)
- Endocardial Tube Cells Endocardium
- Thyroid (Endocrine System)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Liver (Hepatobiliary System)
- Ovary (Reproductive System)
-
Eye (Sensory Organs)
mRNA differential expression in normal tissues according to GTEx for ADD2 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x8.0), Brain - Cerebellum (x5.9), Brain - Frontal Cortex (BA9) (x5.2), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Cortex (x4.5).
This gene is overexpressed in Brain (27.3), Frontal cortex (26.1), and Fetal Brain (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADD2 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADD2 Gene:
ADD2SOURCE GeneReport for Unigene cluster for ADD2 Gene:
Hs.188528mRNA Expression by UniProt/SwissProt for ADD2 Gene:
P35612-ADDB_HUMAN
Tissue specificity:
Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line.
Evidence on tissue expression from TISSUES for ADD2 Gene
- Nervous system(5)
- Blood(4.5)
- Eye(4.4)
- Bone marrow(4.3)
- Heart(4.3)
- Liver(4.2)
Primer Products
-
OriGene qPCR primer pairs and template standards for ADD2
-
OriGene qPCR primer pairs for ADD2
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADD2 Gene
Orthologs for ADD2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADD2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ADD2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADD2 35 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ADD2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Add2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Add2 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| chicken (Gallus gallus) |
Aves | ADD2 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADD2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | add2 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | add2 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | hts 36 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | add-1 35 |
|
ManyToMany | |
| add-2 35 |
|
ManyToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for ADD2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADD2 Gene
(2) SIMAP similar genes for ADD2 Gene using alignment to 6 proteins:
Variants for ADD2 Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000023958 | -- | 70,671,589(+) | AGAAT(C/T)GGAGG | intron-variant, upstream-variant-2KB | |
| rs1000055079 | -- | 70,671,379(+) | TAGAG(A/G)AGCCT | intron-variant, upstream-variant-2KB | |
| rs1000067782 | -- | 70,755,504(+) | CACTA(C/G)AGTGT | intron-variant | |
| rs1000117222 | -- | 70,715,453(+) | ACAGT(A/G)TGAGC | intron-variant | |
| rs1000142601 | -- | 70,709,102(+) | AGGCA(A/G)TGGGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2659183 | CNV | deletion | 23128226 |
| esv2762674 | CNV | gain | 21179565 |
| esv3429524 | CNV | insertion | 20981092 |
| esv3583858 | CNV | loss | 25503493 |
| esv3591211 | CNV | loss | 21293372 |
| esv3892614 | CNV | gain | 25118596 |
| nsv1146915 | OTHER | inversion | 26484159 |
| nsv2770 | CNV | insertion | 18451855 |
| nsv582192 | CNV | loss | 21841781 |
Residual Variation Intolerance Score:
15.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.42;
63.83% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ADD2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- ADD2
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADD2 Gene
Disorders for ADD2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| capillariasis |
|
|
| echolalia |
|
|
| hereditary spherocytosis |
|
|
| exhibitionism |
|
|
| hypertension, essential |
|
Search ADD2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ADD2
No data available for UniProtKB/Swiss-Prot and Genatlas for ADD2 Gene
Publications for ADD2 Gene
- Primary structure and domain organization of human alpha and beta adducin. (PMID: 1840603) Joshi R.L. … Bennett V.D. (J. Cell Biol. 1991) 2 3 4 22 64
- alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy. (PMID: 19838659) Ferrandi M. … Bianchi G. (J. Mol. Med. 2010) 3 22 46 64
- Arterial properties in relation to genetic variations in the adducin subunits in a white population. (PMID: 18787518) SeidlerovA! J. … Bianchi G. (Am. J. Hypertens. 2009) 3 22 46 64
- Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in MAcniA"re's syndrome. (PMID: 18667944) Teggi R. … Bussi M. (Otol. Neurotol. 2008) 3 22 46 64
- Investigation of Adducin 2 (beta) DNA polymorphisms in genetic predisposition to diabetic nephropathy in Type 1 diabetes. (PMID: 18959617) Currie D. … McKnight A.J. (Diabet. Med. 2008) 3 22 46 64
Products for ADD2 Gene
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- antibodies-online Antibodies for ADD2: See all 51
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- Mammalian expression: PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
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