Aliases for ADD1 Gene
Aliases for ADD1 Gene
External Ids for ADD1 Gene
- HGNC: 243
- Entrez Gene: 118
- Ensembl: ENSG00000087274
- OMIM: 102680
- UniProtKB: P35611
Previous GeneCards Identifiers for ADD1 Gene
- GC04P002834
- GC04P002876
- GC04P002882
- GC04P002849
- GC04P002846
- GC04P002847
- GC04P002848
- GC04P002850
- GC04P002852
Summaries for ADD1 Gene
-
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADD1 Gene
ADD1 (Adducin 1) is a Protein Coding gene. Diseases associated with ADD1 include Hypertension, Essential and Gastroschisis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Diuretics Pathway, Pharmacodynamics. GO annotations related to this gene include poly(A) RNA binding and protein heterodimerization activity. An important paralog of this gene is ADD3.
UniProtKB/Swiss-Prot for ADD1 Gene
-
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADD1 Gene
Genomics for ADD1 Gene
Regulatory Elements for ADD1 Gene
Enhancers for ADD1 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ADD1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ADD1 gene promoter:
Regulatory Element Products
Genomic Location for ADD1 Gene
- Chromosome:
- 4
- Start:
- 2,843,727 bp from pter
- End:
- 2,930,076 bp from pter
- Size:
- 86,350 bases
- Orientation:
- Plus strand
Genomic View for ADD1 Gene
Genes around ADD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 4p16.3 by Ensembl
- 4p16.3 by Entrez Gene
- 4p16.3 by HGNC
ADD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADD1 Gene
Proteins for ADD1 Gene
-
Protein details for ADD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P35611-ADDA_HUMAN
- Recommended name:
- Alpha-adducin
- Protein Accession:
- P35611
- A2A3N8
- A2A3P0
- B4DI79
- D3DVR3
- D3DVR4
- D3DVR5
- Q13734
- Q14729
- Q16156
- Q86XM2
- Q9UJB6
Protein attributes for ADD1 Gene
- Size:
- 737 amino acids
- Molecular mass:
- 80955 Da
- Quaternary structure:
-
- Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit.
- SequenceCaution:
-
- Sequence=CAA98970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for ADD1 Gene
Post-translational modifications for ADD1 Gene
Other Protein References for ADD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ADD1
- Cell Signaling Technology (CST) Antibodies for ADD1 (ADD1)
- Novus Biologicals Antibodies for ADD1
-
Abcam antibodies for ADD1
-
Cloud-Clone Corp. Antibodies for ADD1
- Invitrogen Antibodies for ADD1
- antibodies-online Antibodies for ADD1: See all 171
- GeneTex ADD1 antibody for ADD1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADD1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for ADD1
- Origene Custom Protein Services for ADD1
-
Cloud-Clone Corp. Proteins for ADD1
- antibodies-online Proteins for ADD1: See all 5
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ADD1
-
Abcam proteins for ADD1
Assay Products
- antibodies-online Kits for ADD1: See all 2
No data available for DME Specific Peptides for ADD1 Gene
Domains & Families for ADD1 Gene
Protein Domains for ADD1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADD1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P35611UniProtKB/Swiss-Prot:
ADDA_HUMAN :- Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
- Belongs to the aldolase class II family. Adducin subfamily.
- Domain:
-
- Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region.
- Family:
-
- Belongs to the aldolase class II family. Adducin subfamily.
No data available for Gene Families for ADD1 Gene
Function for ADD1 Gene
Molecular function for ADD1 Gene
- GENATLAS Biochemistry:
- adducin alpha,actin accessory protein,calmodulin binding protein,80kDa,component of the erythrocyte membrane skeleton,with an alternatively spliced isoform (70kDa)
- UniProtKB/Swiss-Prot Function:
- Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA | 22658674 |
| GO:0003779 | actin binding | TAS | 1840603 |
| GO:0005198 | structural molecule activity | IEA | -- |
| GO:0005516 | calmodulin binding | IEA | -- |
| GO:0008134 | transcription factor binding | IPI | 16289097 |
Phenotypes for ADD1 Gene
- MGI mutant phenotypes for ADD1:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for ADD1:
-
- Increased viability
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Increased transferrin (TF) endocytosis
- Increased shRNA abundance (Z-score > 2)
- Increased G1 DNA content
- Decreased shRNA abundance (Z-score < -2)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Increased shRNA abundance
Animal Models for ADD1 Gene
- MGI Knock Outs for ADD1:
-
- Add1 tm1Llp
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADD1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADD1 gene
- Search ViGene Biosciences for ADD1
CRISPR Products
-
OriGene CRISPR knockouts for ADD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADD1
- GenScript: Design CRISPR guide RNA sequences for ADD1
miRNA for ADD1 Gene
- miRTarBase miRNAs that target ADD1
-
- hsa-mir-24-3p (MIRT030434)
- hsa-mir-221-3p (MIRT046898)
- hsa-mir-27a-3p (MIRT093744)
- hsa-mir-27b-3p (MIRT093745)
- hsa-mir-513a-5p (MIRT093746)
- hsa-mir-17-5p (MIRT164719)
- hsa-mir-20a-5p (MIRT164720)
- hsa-mir-93-5p (MIRT164721)
- hsa-mir-106b-5p (MIRT164727)
- hsa-mir-20b-5p (MIRT164735)
- hsa-mir-519d-3p (MIRT164744)
- hsa-mir-3681-3p (MIRT503185)
- hsa-mir-216a-3p (MIRT503186)
- hsa-mir-128-3p (MIRT503187)
- hsa-mir-4684-5p (MIRT644217)
- hsa-mir-6868-3p (MIRT644218)
- hsa-mir-6749-3p (MIRT644219)
- hsa-mir-6792-3p (MIRT644220)
- hsa-mir-4691-5p (MIRT644221)
- hsa-mir-3143 (MIRT644222)
- hsa-mir-27a-5p (MIRT644223)
- hsa-mir-942-5p (MIRT644224)
- hsa-mir-520f-5p (MIRT644225)
- hsa-mir-1248 (MIRT644226)
- hsa-mir-1237-3p (MIRT644227)
- hsa-mir-660-3p (MIRT644228)
- hsa-mir-543 (MIRT644229)
miRNA Products
- Search ViGene Biosciences for ADD1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ADD1
- Browse OriGene Inhibitory RNA Products For ADD1
-
ViGene Biosciences ready-to-package AAV shRNAs for ADD1 gene
Clone Products
-
OriGene ORF clones in human for ADD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADD1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ADD1
-
ViGene Biosciences adenoviral particle packaged cDNA for ADD1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADD1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADD1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADD1 Gene
Localization for ADD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADD1 Gene
- Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytoskeleton | 5 |
| nucleus | 5 |
| cytosol | 5 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IDA | 16289097 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IDA,IEA | 25978380 |
| GO:0005829 | cytosol | TAS | -- |
| GO:0005856 | cytoskeleton | IEA | -- |
Pathways & Interactions for ADD1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | Apoptotic cleavage of cellular proteins | ||
| 3 | Unfolded Protein Response (UPR) | ||
| 4 | CDK-mediated phosphorylation and removal of Cdc6 |
.31
|
|
| 5 | Diuretics Pathway, Pharmacodynamics | ||
Pathways by source for ADD1 Gene
2 Cell Signaling Technology pathways for ADD1 Gene
11 Reactome pathways for ADD1 Gene
1 PharmGKB pathway for ADD1 Gene
2 GeneGo (Thomson Reuters) pathways for ADD1 Gene
4 Qiagen pathways for ADD1 Gene
Interacting Proteins for ADD1 Gene
Selected Interacting proteins:
ENSP00000264758
P35611-ADDA_HUMAN
for ADD1 Gene via
STRING
MINT
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000902 | cell morphogenesis | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0006884 | cell volume homeostasis | IEA | -- |
| GO:0020027 | hemoglobin metabolic process | IEA | -- |
| GO:0030036 | actin cytoskeleton organization | IC | 3693401 |
Drugs & Compounds for ADD1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Hydrochlorothiazide | Approved, Vet_approved | Pharma | Inhibition, Inhibitor | 413 | ||
| Bumetanide | Approved | Pharma | Agonist | NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor | 17 | |
| Furosemide | Approved, Vet_approved | Pharma | Agonist | GABAA receptors antagonist, Na+/2Cl-/K+ (NKCC) symporter inhibitor. Also antagonizes GABAA | 193 | |
| Spironolactone | Approved | Pharma | Antagonist | 232 | ||
| Torasemide | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for ADD1 Gene
mRNA/cDNA for ADD1 Gene
- (18) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (492) Selected AceView cDNA sequences:
- (28) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ADD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADD1
- GenScript: Design CRISPR guide RNA sequences for ADD1
miRNA Products
- Search ViGene Biosciences for ADD1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ADD1
- Browse OriGene Inhibitory RNA Products For ADD1
-
ViGene Biosciences ready-to-package AAV shRNAs for ADD1 gene
Clone Products
-
OriGene ORF clones in human for ADD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for ADD1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | · | 12d | ^ | 13a | · | 13b | · | 13c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: |
| ExUns: | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||
| SP2: | - | - | - | ||||||||||||
| SP3: | - | - | |||||||||||||
| SP4: | |||||||||||||||
| SP5: | |||||||||||||||
| SP6: | |||||||||||||||
| SP7: | |||||||||||||||
| SP8: | - | ||||||||||||||
| SP9: | |||||||||||||||
| SP10: | |||||||||||||||
| SP11: | |||||||||||||||
| SP12: |
Expression for ADD1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Ovary (Reproductive System)
- Ovarian Mesenchymal Stroma Cells Ovary Interstitium
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Adipose (Muscoskeletal System)
This gene is overexpressed in Brain (11.4) and Frontal cortex (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADD1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADD1 Gene:
ADD1SOURCE GeneReport for Unigene cluster for ADD1 Gene:
Hs.183706mRNA Expression by UniProt/SwissProt for ADD1 Gene:
P35611-ADDA_HUMAN
Tissue specificity:
Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit.
Evidence on tissue expression from TISSUES for ADD1 Gene
- Nervous system(4.9)
- Blood(4.5)
- Liver(4.4)
- Eye(4)
- Kidney(3.2)
- Lung(2.9)
- Muscle(2.6)
- Heart(2.2)
- Intestine(2.1)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for ADD1
-
OriGene qPCR primer pairs and template standards for ADD1
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADD1 Gene
Orthologs for ADD1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADD1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ADD1 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Add1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Add1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ADD1 34 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADD1 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ADD1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADD1 35 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | ADD1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | add1 34 |
|
||
| Str.1405 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | add1 34 34 35 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | hts 34 35 36 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004852 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | add-1 34 35 |
|
||
| add-2 36 35 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
ManyToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.12741 34 |
|
- Species where no ortholog for ADD1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADD1 Gene
(3) SIMAP similar genes for ADD1 Gene using alignment to 12 proteins:
Pseudogenes.org Pseudogenes for ADD1 Gene
Variants for ADD1 Gene
| SNP ID | Clin | Chr 04 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs4961 | drug-response | 2,904,980(+) | AGGAA(G/T)GGCAG | reference, missense | |
| rs1000002666 | -- | 2,899,930(+) | AGAAG(G/T)CGGGC | intron-variant | |
| rs1000009237 | -- | 2,860,569(+) | GAAAT(A/G)TATTT | intron-variant | |
| rs1000035324 | -- | 2,900,219(+) | CGTAC(A/G)GTGCA | intron-variant | |
| rs1000035585 | -- | 2,857,270(+) | AGCTG(C/T)TACTC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv313n21 | CNV | gain | 19592680 |
| esv1007958 | CNV | deletion | 20482838 |
| esv2726835 | CNV | deletion | 23290073 |
| esv2726864 | CNV | deletion | 23290073 |
| esv3335256 | CNV | insertion | 20981092 |
| esv3383963 | CNV | duplication | 20981092 |
| esv3419163 | CNV | duplication | 20981092 |
| esv3599411 | CNV | loss | 21293372 |
| nsv461162 | CNV | loss | 19166990 |
| nsv461163 | CNV | gain | 19166990 |
| nsv526059 | CNV | loss | 19592680 |
| nsv593435 | CNV | loss | 21841781 |
| nsv593436 | CNV | loss | 21841781 |
| nsv593437 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
38.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.11;
96.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ADD1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADD1 Gene
Disorders for ADD1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hypertension, essential |
|
|
| gastroschisis |
|
|
| pediatric hypertension |
|
|
| meningococcal infection |
|
|
| hereditary elliptocytosis |
|
|
Search ADD1 in MalaCards
View complete list of genes associated with diseases
Genatlas disease for ADD1 Gene
salt sensitivity in patients with essential hypertension,associated with ADD1 polymorphism (G460W)
Relevant External Links for ADD1
No data available for UniProtKB/Swiss-Prot for ADD1 Gene
Publications for ADD1 Gene
- alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy. (PMID: 19838659) Ferrandi M. … Bianchi G. (J. Mol. Med. 2010) 3 22 46 64
- The influence of six cardiovascular polymorphisms on a first event of ischemic heart disease is modified by sex and age. (PMID: 19779330) Plat A.W. … Kroon A.A. (Coron. Artery Dis. 2009) 3 22 46 64
- Arterial properties in relation to genetic variations in the adducin subunits in a white population. (PMID: 18787518) SeidlerovA! J. … Bianchi G. (Am. J. Hypertens. 2009) 3 22 46 64
- Arterial properties in relation to genetic variation in alpha-adducin and the renin-angiotensin system in a White population. (PMID: 18800139) SeidlerovA! J. … Filipovsk Ygrave J. (J Hum Hypertens 2009) 3 22 46 64
- Renin-angiotensin system and alpha-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study. (PMID: 19057513) SuonsyrjAo T. … Hiltunen T.P. (Am. J. Hypertens. 2009) 3 22 46 64
Products for ADD1 Gene
- Browse R&D Systems for Antibodies
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- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for ADD1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for ADD1
- Origene Custom Protein Services for ADD1
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ADD1
- Browse OriGene Inhibitory RNA Products For ADD1
- OriGene qPCR primer pairs and template standards for ADD1
- OriGene qPCR primer pairs for ADD1
- OriGene CRISPR knockouts for ADD1
- OriGene ORF clones in human for ADD1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADD1
- GenScript: Next-day shipping cDNA ORF clone for ADD1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ADD1
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- GenScript: Design CRISPR guide RNA sequences for ADD1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ADD1
- Cell Signaling Technology (CST) Antibodies for ADD1 (ADD1)
- Search for Antibodies & Assays
- Sino Biological Human cDNA Clone for ADD1
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
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- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ADD1
- Novus Biologicals proteins and lysates for ADD1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Abcam antibodies for ADD1
- Abcam proteins for ADD1
- Search for Assays for ADD1 at Abcam
- Find your target
- Search knockout validated antibodies
- Browse monoclonal antibodies
- Cloud-Clone Corp. Antibodies for ADD1
- Cloud-Clone Corp. Proteins for ADD1
- Browse Assay Kits at Cloud-Clone Corp.
- antibodies-online Antibodies for ADD1: See all 171
- antibodies-online Kits for ADD1: See all 2
- antibodies-online Proteins for ADD1: See all 5
- Search antibodies-online for peptides
- GeneTex ADD1 antibody for ADD1
- Search GeneTex for Proteins for ADD1
- ViGene Biosciences adenoviral particle packaged cDNA for ADD1 gene
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- Search ViGene Biosciences for ADD1
- Santa Cruz Biotechnology (SCBT) Antibodies for ADD1
- Search Santa Cruz Biotechnology (SCBT) for ADD1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADD1
- Horizon Cell Lines for ADD1
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADD1
- VectorBuilder custom plasmid, inducible vectors for ADD1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADD1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ADD1 Gene
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- (50) eBioscience
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- (52) Cell Signaling Technology
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- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
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