Aliases for ADD1 Gene
External Ids for ADD1 Gene
Previous GeneCards Identifiers for ADD1 Gene
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADD1 Gene
ADD1 (Adducin 1 (Alpha)) is a Protein Coding gene. Diseases associated with ADD1 include hypertension, essential and gastroschisis. Among its related pathways are Activation of cAMP-Dependent PKA and Transport to the Golgi and subsequent modification. GO annotations related to this gene include poly(A) RNA binding and protein heterodimerization activity. An important paralog of this gene is ADD2.
UniProtKB/Swiss-Prot for ADD1 Gene
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin