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Aliases for ADD1 Gene

Aliases for ADD1 Gene

  • Adducin 1 (Alpha) 2 3
  • ADDA 3 4
  • Erythrocyte Adducin Alpha Subunit 3
  • Erythrocyte Adducin Subunit Alpha 4
  • Alpha-Adducin 3

External Ids for ADD1 Gene

Previous GeneCards Identifiers for ADD1 Gene

  • GC04P002834
  • GC04P002876
  • GC04P002882
  • GC04P002849

Summaries for ADD1 Gene

Entrez Gene Summary for ADD1 Gene

  • Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADD1 Gene

ADD1 (Adducin 1 (Alpha)) is a Protein Coding gene. Diseases associated with ADD1 include hypertension, essential and gastroschisis. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is ADD2.

UniProtKB/Swiss-Prot for ADD1 Gene

  • Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin

Gene Wiki entry for ADD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADD1 Gene

Genomics for ADD1 Gene

Regulatory Elements for ADD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADD1 Gene

Start:
2,843,727 bp from pter
End:
2,930,076 bp from pter
Size:
86,350 bases
Orientation:
Plus strand

Genomic View for ADD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADD1 Gene

Proteins for ADD1 Gene

  • Protein details for ADD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35611-ADDA_HUMAN
    Recommended name:
    Alpha-adducin
    Protein Accession:
    P35611
    Secondary Accessions:
    • A2A3N8
    • A2A3P0
    • B4DI79
    • D3DVR3
    • D3DVR4
    • D3DVR5
    • Q13734
    • Q14729
    • Q16156
    • Q86XM2
    • Q9UJB6

    Protein attributes for ADD1 Gene

    Size:
    737 amino acids
    Molecular mass:
    80955 Da
    Quaternary structure:
    • Heterodimer of an alpha and a beta subunit or an alpha and a gamma subunit
    SequenceCaution:
    • Sequence=CAA98970.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ADD1 Gene

neXtProt entry for ADD1 Gene

Proteomics data for ADD1 Gene at MOPED

Post-translational modifications for ADD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ADD1 Gene

Domains for ADD1 Gene

Protein Domains for ADD1 Gene

Suggested Antigen Peptide Sequences for ADD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P35611

UniProtKB/Swiss-Prot:

ADDA_HUMAN :
  • P35611
Domain:
  • Each subunit is comprised of three regions: a NH2-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region
Family:
  • Belongs to the aldolase class II family. Adducin subfamily.
genes like me logo Genes that share domains with ADD1: view

No data available for Gene Families for ADD1 Gene

Function for ADD1 Gene

Molecular function for ADD1 Gene

GENATLAS Biochemistry: adducin alpha,actin accessory protein,calmodulin binding protein,80kDa,component of the erythrocyte membrane skeleton,with an alternatively spliced isoform (70kDa)
UniProtKB/Swiss-Prot Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin

Gene Ontology (GO) - Molecular Function for ADD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding TAS 1840603
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005516 calmodulin binding IEA --
GO:0008134 transcription factor binding IPI 16289097
genes like me logo Genes that share ontologies with ADD1: view
genes like me logo Genes that share phenotypes with ADD1: view

Animal Models for ADD1 Gene

MGI Knock Outs for ADD1:

Animal Model Products

miRNA for ADD1 Gene

miRTarBase miRNAs that target ADD1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADD1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ADD1 Gene

Localization for ADD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADD1 Gene

Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADD1 Gene COMPARTMENTS Subcellular localization image for ADD1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
nucleus 4
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16289097
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with ADD1: view

Pathways for ADD1 Gene

genes like me logo Genes that share pathways with ADD1: view

Gene Ontology (GO) - Biological Process for ADD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000902 cell morphogenesis IEA --
GO:0001701 in utero embryonic development IEA --
GO:0006884 cell volume homeostasis IEA --
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
genes like me logo Genes that share ontologies with ADD1: view

Compounds for ADD1 Gene

(17) Novoseek inferred chemical compound relationships for ADD1 Gene

Compound -log(P) Hits PubMed IDs
nppa 74.3 2
sodium 66.3 31
thiazide 64.9 3
hydrochlorothiazide 60.5 7
it 15 60 1

(6) PharmGKB related drug/compound annotations for ADD1 Gene

Drug/compound Annotation
bumetanide CA
diuretics CA
furosemide CA
hydrochlorothiazide CA
spironolactone CA
torasemide CA
genes like me logo Genes that share compounds with ADD1: view

Transcripts for ADD1 Gene

Unigene Clusters for ADD1 Gene

Adducin 1 (alpha):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADD1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADD1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13a · 13b · 13c ^
SP1: - - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: - - - - -
SP7: - - - - - -
SP8:
SP9:
SP10: - - - - - -
SP11: - - -
SP12:

ExUns: 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ADD1 Gene

GeneLoc Exon Structure for
ADD1
ECgene alternative splicing isoforms for
ADD1

Expression for ADD1 Gene

mRNA expression in normal human tissues for ADD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADD1 Gene

SOURCE GeneReport for Unigene cluster for ADD1 Gene Hs.183706

mRNA Expression by UniProt/SwissProt for ADD1 Gene

P35611-ADDA_HUMAN
Tissue specificity: Expressed in all tissues. Found in much higher levels in reticulocytes than the beta subunit
genes like me logo Genes that share expressions with ADD1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADD1 Gene

Orthologs for ADD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADD1 35
  • 99.65 (n)
  • 99.61 (a)
ADD1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADD1 35
  • 88.07 (n)
  • 92.6 (a)
ADD1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADD1 35
  • 89.51 (n)
  • 93.6 (a)
ADD1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Add1 35
  • 88.57 (n)
  • 92.93 (a)
Add1 16
Add1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADD1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADD1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Add1 35
  • 88.44 (n)
  • 92.38 (a)
chicken
(Gallus gallus)
Aves ADD1 35
  • 81.77 (n)
  • 88.07 (a)
ADD1 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADD1 36
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia add1 35
  • 79.33 (n)
  • 87.56 (a)
Str.1405 35
zebrafish
(Danio rerio)
Actinopterygii add1 35
add1 35
  • 72.94 (n)
  • 80.63 (a)
add1 36
  • 71 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004852 35
  • 48.23 (n)
  • 41.59 (a)
fruit fly
(Drosophila melanogaster)
Insecta hts 35
  • 49.32 (n)
  • 42.79 (a)
hts 36
  • 15 (a)
OneToMany
hts 37
  • 38 (a)
worm
(Caenorhabditis elegans)
Secernentea add-1 35
  • 50.12 (n)
  • 42.7 (a)
add-1 36
  • 33 (a)
ManyToMany
add-2 36
  • 28 (a)
ManyToMany
add-2 37
  • 50 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12741 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
Species with no ortholog for ADD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADD1 Gene

ENSEMBL:
Gene Tree for ADD1 (if available)
TreeFam:
Gene Tree for ADD1 (if available)

Paralogs for ADD1 Gene

Paralogs for ADD1 Gene

Pseudogenes.org Pseudogenes for ADD1 Gene

genes like me logo Genes that share paralogs with ADD1: view

Variants for ADD1 Gene

Sequence variations from dbSNP and Humsavar for ADD1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4741 -- 2,929,470(+) ACATC(A/G)CCGTC utr-variant-3-prime
rs4960 -- 2,843,951(+) GAGCC(A/G)GAGCC utr-variant-5-prime, upstream-variant-2KB
rs4961 other, - 2,904,980(+) AGGAA(G/T)GGCAG reference, missense
rs4962 - 2,908,528(+) GCAGA(A/T)TTTAC reference, missense
rs4963 - 2,915,035(+) GGGCT(C/G/T)TGAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADD1 Gene

Variant ID Type Subtype PubMed ID
esv2726835 CNV Deletion 23290073
nsv878444 CNV Loss 21882294
dgv5426n71 CNV Loss 21882294
dgv5427n71 CNV Loss 21882294
nsv878451 CNV Loss 21882294
nsv461162 CNV Loss 19166990
dgv313n21 CNV Gain 19592680
nsv526059 CNV Loss 19592680
esv2726864 CNV Deletion 23290073
esv1007958 CNV Deletion 20482838
nsv461163 CNV Gain 19166990

Relevant External Links for ADD1 Gene

HapMap Linkage Disequilibrium report
ADD1
Human Gene Mutation Database (HGMD)
ADD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADD1 Gene

Disorders for ADD1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for ADD1 Gene including...

Search for ADD1 Gene in MalaCards »

(1) OMIM Diseases for ADD1 Gene (102680)

(1) University of Copenhagen DISEASES for ADD1 Gene

(16) Novoseek inferred disease relationships for ADD1 Gene

Disease -log(P) Hits PubMed IDs
essential hypertension 80.2 33
hyperlipidemia familial combined 45.4 1
genetic susceptibility 41.2 2
nephropathy iga 35.7 3
huntington disease 32.3 2

Genatlas disease for ADD1 Gene

salt sensitivity in patients with essential hypertension,associated with ADD1 polymorphism (G460W)

Relevant External Links for ADD1

Genetic Association Database (GAD)
ADD1
Human Genome Epidemiology (HuGE) Navigator
ADD1
genes like me logo Genes that share disorders with ADD1: view

No data available for UniProtKB/Swiss-Prot for ADD1 Gene

Publications for ADD1 Gene

  1. Adducin regulation. Definition of the calmodulin-binding domain and sites of phosphorylation by protein kinases A and C. (PMID: 8810272) Matsuoka Y. … Bennett V. (J. Biol. Chem. 1996) 3 4 23
  2. [Is Gly460Trp variant of alpha-adducin associated with essential hypertension in the Hans of Chinese population]. (PMID: 11110979) Hou R. … Liu Y. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2000) 3 23 48
  3. alpha-adducin and angiotensin I-converting enzyme polymorphisms in essential hypertension. (PMID: 11116113) Clark C.J. … Connell J.M. (Hypertension 2000) 3 23 48
  4. G-protein beta3 subunit and alpha-adducin polymorphisms and risk of subclinical and clinical stroke. (PMID: 11283377) Morrison A.C. … Boerwinkle E. (Stroke 2001) 3 23 48
  5. Effects of three candidate genes on prevalence and incidence of hypertension in a Caucasian population. (PMID: 11518842) Staessen J.A. … Bianchi G. (J. Hypertens. 2001) 3 23 48

Products for ADD1 Gene

Sources for ADD1 Gene

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