Aliases for ADD1 Gene
External Ids for ADD1 Gene
Previous GeneCards Identifiers for ADD1 Gene
Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADD1 Gene
ADD1 (Adducin 1 (Alpha)) is a Protein Coding gene. Diseases associated with ADD1 include hypertension, essential and gastroschisis. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include protein homodimerization activity and actin binding. An important paralog of this gene is ADD2.
UniProtKB/Swiss-Prot for ADD1 Gene
Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin