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Aliases for ADCYAP1R1 Gene

Aliases for ADCYAP1R1 Gene

  • Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type I 2 3
  • PACAP Type I Receptor 3 4
  • PACAP Receptor 1 2 3
  • PACAP-R1 3 4
  • PACAPR 3 6
  • Pituitary Adenylate Cyclase Activating Polypeptide 1 Receptor Type I Hiphop 3
  • Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor 3
  • PACAP-R-1 4
  • PACAPRI 3
  • PAC1R 3
  • PAC1 3

External Ids for ADCYAP1R1 Gene

Previous GeneCards Identifiers for ADCYAP1R1 Gene

  • GC07P030734
  • GC07P030834
  • GC07P030865

Summaries for ADCYAP1R1 Gene

Entrez Gene Summary for ADCYAP1R1 Gene

  • This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

GeneCards Summary for ADCYAP1R1 Gene

ADCYAP1R1 (Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type I) is a Protein Coding gene. Diseases associated with ADCYAP1R1 include post-traumatic stress disorder. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include receptor activity and ADP-ribosylation factor binding. An important paralog of this gene is VIPR2.

UniProtKB/Swiss-Prot for ADCYAP1R1 Gene

  • This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract

Tocris Summary for ADCYAP1R1 Gene

  • Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock, emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human PAC1 receptor gene has been localized to chromosome 7p14.

Gene Wiki entry for ADCYAP1R1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCYAP1R1 Gene

Genomics for ADCYAP1R1 Gene

Regulatory Elements for ADCYAP1R1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCYAP1R1 Gene

Start:
31,052,461 bp from pter
End:
31,111,479 bp from pter
Size:
59,019 bases
Orientation:
Plus strand

Genomic View for ADCYAP1R1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCYAP1R1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCYAP1R1 Gene

Proteins for ADCYAP1R1 Gene

  • Protein details for ADCYAP1R1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41586-PACR_HUMAN
    Recommended name:
    Pituitary adenylate cyclase-activating polypeptide type I receptor
    Protein Accession:
    P41586
    Secondary Accessions:
    • A8K1Y1
    • B7ZLA7
    • B8ZZK3
    • Q17S10

    Protein attributes for ADCYAP1R1 Gene

    Size:
    468 amino acids
    Molecular mass:
    53314 Da
    Quaternary structure:
    • Interacts (via N-terminal extracellular domain) with ADCYAP1.
    SequenceCaution:
    • Sequence=BAA04466.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADCYAP1R1 Gene

    Alternative splice isoforms for ADCYAP1R1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCYAP1R1 Gene

Proteomics data for ADCYAP1R1 Gene at MOPED

Post-translational modifications for ADCYAP1R1 Gene

  • Glycosylation at Asn48, Asn60, Asn117, Asn300, and Asn375
  • Modification sites at PhosphoSitePlus

Other Protein References for ADCYAP1R1 Gene

Antibody Products

No data available for DME Specific Peptides for ADCYAP1R1 Gene

Domains for ADCYAP1R1 Gene

Gene Families for ADCYAP1R1 Gene

HGNC:
  • VIPPACR :GPCR / Class B : VIP and PACAP (ADCYAP1) receptors
IUPHAR :

Graphical View of Domain Structure for InterPro Entry

P41586

UniProtKB/Swiss-Prot:

PACR_HUMAN :
  • P41586
Family:
  • Belongs to the G-protein coupled receptor 2 family.
genes like me logo Genes that share domains with ADCYAP1R1: view

Function for ADCYAP1R1 Gene

Molecular function for ADCYAP1R1 Gene

GENATLAS Biochemistry: pituitary adenylyl cyclase activating polypeptide receptor,with five splice variants among which four also activating phospholipase C and a sixth variant (PACAPR-TM4) activating L-type Ca++ channels,expressed in islet beta cells and involved in the physiological control of insulin release
UniProtKB/Swiss-Prot Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract

Gene Ontology (GO) - Molecular Function for ADCYAP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 7902709
GO:0004888 transmembrane signaling receptor activity --
GO:0004930 G-protein coupled receptor activity --
GO:0004999 vasoactive intestinal polypeptide receptor activity IEA --
GO:0005515 protein binding IPI 17470806
genes like me logo Genes that share ontologies with ADCYAP1R1: view
genes like me logo Genes that share phenotypes with ADCYAP1R1: view

Animal Models for ADCYAP1R1 Gene

MGI Knock Outs for ADCYAP1R1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCYAP1R1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADCYAP1R1 Gene

Localization for ADCYAP1R1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCYAP1R1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCYAP1R1 Gene COMPARTMENTS Subcellular localization image for ADCYAP1R1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
endosome 2

Gene Ontology (GO) - Cellular Components for ADCYAP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005768 endosome IEA --
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7902709
genes like me logo Genes that share ontologies with ADCYAP1R1: view

Pathways for ADCYAP1R1 Gene

genes like me logo Genes that share pathways with ADCYAP1R1: view

Pathways by source for ADCYAP1R1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for ADCYAP1R1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 7902709
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007190 activation of adenylate cyclase activity TAS --
GO:0007202 activation of phospholipase C activity IEA --
genes like me logo Genes that share ontologies with ADCYAP1R1: view

Compounds for ADCYAP1R1 Gene

(1) Tocris Compounds for ADCYAP1R1 Gene

Compound Action Cas Number
PACAP 6-38 Potent PAC1 receptor antagonist [143748-18-9]

(15) IUPHAR Ligand for ADCYAP1R1 Gene

Ligand Type Action Affinity Pubmed IDs
maxadilan Agonist Agonist 10.3
PACAP-38 Agonist Agonist 10.3
[125I]PACAP-27 Agonist Agonist 9.1
PACAP-27 Agonist Agonist 8.5
N-stearyl-[Nle17] neurotensin-(6-11)/VIP-(7-28) Antagonist Antagonist 7.2
PG 99-465 Agonist Agonist 7.1
M65 Antagonist Antagonist 6.8
VIP Agonist Agonist 6.3
Ro 25-1553 Agonist Agonist 6
[Ala11,22,28]VIP Agonist Agonist 5.8
BAY 55-9837 Agonist Agonist 5
PG 97-269 Antagonist Antagonist
[Arg16]chicken secretin Agonist Full agonist
[125I]VIP Agonist Full agonist
[Lys15,Arg16,Leu27]VIP-(1?ao7)/GRF-(8?ao27)-NH2 Agonist Full agonist

(4) Novoseek inferred chemical compound relationships for ADCYAP1R1 Gene

Compound -log(P) Hits PubMed IDs
pacap 38 82.7 2
adenylate 80.4 12
ribonucleic acid 37.4 1
calcium 0 2
genes like me logo Genes that share compounds with ADCYAP1R1: view

Transcripts for ADCYAP1R1 Gene

Unigene Clusters for ADCYAP1R1 Gene

Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCYAP1R1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCYAP1R1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18
SP1: - -
SP2: -
SP3:
SP4: - -
SP5:
SP6: -
SP7: -
SP8:
SP9:

Relevant External Links for ADCYAP1R1 Gene

GeneLoc Exon Structure for
ADCYAP1R1
ECgene alternative splicing isoforms for
ADCYAP1R1

Expression for ADCYAP1R1 Gene

mRNA expression in normal human tissues for ADCYAP1R1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCYAP1R1 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (4.9), Brain - Amygdala (4.9), Brain - Caudate (basal ganglia) (4.9), and Brain - Hypothalamus (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCYAP1R1 Gene

SOURCE GeneReport for Unigene cluster for ADCYAP1R1 Gene Hs.377783

mRNA Expression by UniProt/SwissProt for ADCYAP1R1 Gene

P41586-PACR_HUMAN
Tissue specificity: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta
genes like me logo Genes that share expressions with ADCYAP1R1: view

In Situ Assay Products

Orthologs for ADCYAP1R1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADCYAP1R1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCYAP1R1 35
  • 99.66 (n)
  • 100 (a)
ADCYAP1R1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCYAP1R1 35
  • 91.47 (n)
  • 95.77 (a)
ADCYAP1R1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCYAP1R1 35
  • 90.39 (n)
  • 93.95 (a)
ADCYAP1R1 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcyap1r1 35
  • 88.91 (n)
  • 93.15 (a)
Adcyap1r1 16
Adcyap1r1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCYAP1R1 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCYAP1R1 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcyap1r1 35
  • 89.19 (n)
  • 94.32 (a)
chicken
(Gallus gallus)
Aves ADCYAP1R1 35
  • 76.81 (n)
  • 85.68 (a)
ADCYAP1R1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCYAP1R1 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia adcyap1r1-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia adcyap1r1 35
  • 72.19 (n)
  • 78.68 (a)
zebrafish
(Danio rerio)
Actinopterygii ADCYAP1R1 (2 of 2) 36
  • 76 (a)
OneToMany
adcyap1r1a 35
  • 74.16 (n)
  • 79.33 (a)
adcyap1r1a 36
  • 85 (a)
OneToMany
Species with no ortholog for ADCYAP1R1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADCYAP1R1 Gene

ENSEMBL:
Gene Tree for ADCYAP1R1 (if available)
TreeFam:
Gene Tree for ADCYAP1R1 (if available)

Paralogs for ADCYAP1R1 Gene

Paralogs for ADCYAP1R1 Gene

Selected SIMAP similar genes for ADCYAP1R1 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ADCYAP1R1: view

Variants for ADCYAP1R1 Gene

Sequence variations from dbSNP and Humsavar for ADCYAP1R1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs741051 -- 31,054,176(+) CCAAC(C/T)GATCC intron-variant
rs741052 -- 31,055,925(-) GAATC(A/G)ATCAC intron-variant
rs741053 -- 31,056,155(-) TCCTT(G/T)GAGCT intron-variant
rs741055 -- 31,069,495(+) ATATA(C/T)TTGTA intron-variant
rs741056 -- 31,069,843(+) GCTTG(C/G)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCYAP1R1 Gene

Variant ID Type Subtype PubMed ID
nsv436557 CNV Deletion 17901297
nsv527038 CNV Gain 19592680
nsv464418 CNV Loss 19166990
nsv5685 CNV Insertion 18451855
nsv519081 CNV Loss 19592680

Relevant External Links for ADCYAP1R1 Gene

HapMap Linkage Disequilibrium report
ADCYAP1R1
Human Gene Mutation Database (HGMD)
ADCYAP1R1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCYAP1R1 Gene

Disorders for ADCYAP1R1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADCYAP1R1 Gene including...

Search for ADCYAP1R1 Gene in MalaCards »

Relevant External Links for ADCYAP1R1

Genetic Association Database (GAD)
ADCYAP1R1
Human Genome Epidemiology (HuGE) Navigator
ADCYAP1R1
genes like me logo Genes that share disorders with ADCYAP1R1: view

No data available for UniProtKB/Swiss-Prot for ADCYAP1R1 Gene

Publications for ADCYAP1R1 Gene

  1. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. (PMID: 7902709) Ogi K. … Fujino M. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 23
  2. Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7. (PMID: 7851900) Stoffel M. … Bell G.I. (Genomics 1994) 3 4 23
  3. Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. (PMID: 17470806) Sun C. … Olejniczak E.T. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4
  4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 48
  5. Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta. (PMID: 10698193) Scaldaferri M.L. … Moretti C. (Endocrinology 2000) 3 23

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