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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCYAP1R1 Gene

protein-coding   GIFtS: 60
GCID: GC07P031058

adenylate cyclase activating polypeptide 1 (pituitary) receptor...
 Explore 18 diseases affiliated with
ADCYAP1R1 via
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 Human Malady Compendium 
Biological research products
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Aliases
for ADCYAP1R1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type I1 2     PACAPRI2
PACAPR1 2 5     PACAP Receptor 12
PAC11 2     Pituitary Adenylate Cyclase Activating Polypeptide 1 Receptor Type I Hiphop2
PAC1R1 2     Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor2
PACAP-R12 3     PACAP-R-13
PACAP Type I Receptor2 3     

External Ids:    HGNC: 2421   Entrez Gene: 1172   Ensembl: ENSG000000785497   OMIM: 1029815   UniProtKB: P415863   

Export aliases for ADCYAP1R1 gene to outside databases

Previous GC identifers: GC07P030734 GC07P030834 GC07P030865


Summaries
for ADCYAP1R1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADCYAP1R1:
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and
shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse
biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. (provided by
RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: PACR_HUMAN, P41586
Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which
activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone,
prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle
relaxation and secretion in the gastrointestinal tract

summary for ADCYAP1R1:
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors
referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1
receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb,
thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the
adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock,
emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human
PAC1 receptor gene has been localized to chromosome 7p14.

Gene Wiki entry for ADCYAP1R1


Genomic Views
for ADCYAP1R1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCYAP1R1 gene promoter:
         RP58   p53   Bach2   Nkx2-5   LCR-F1   FOXL1   C/EBPalpha   HEN1   FAC1   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ADCYAP1R1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCYAP1R1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCYAP1R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

ADCYAP1R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCYAP1R1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P031058:  view genomic region     (about GC identifiers)

Start:
 31,092,076 bp from pter      End:
 31,151,089 bp from pter
Size:
 59,014 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 31,141,320-31,195,489     

Proteins
for ADCYAP1R1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PACR_HUMAN, P41586 (See protein sequence)
Recommended Name: Pituitary adenylate cyclase-activating polypeptide type I receptor precursor  
Size: 468 amino acids; 53314 Da
Subunit: Interacts (via N-terminal extracellular domain) with ADCYAP1
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA04466.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for ADCYAP1R1:
2JOD (3D)        3N94 (3D)    
Secondary accessions: A8K1Y1 B7ZLA7 B8ZZK3 Q17S10
Alternative splicing: 5 isoforms:  P41586-1   P41586-2   P41586-3   P41586-4   P41586-5   (Ref.7 (AAI43680) sequence is in conflict in position: 350:S->Missing)

Explore the universe of human proteins at neXtProt for ADCYAP1R1: NX_P41586

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P41586

    • ADCYAP1R1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001109.2  NP_001186564.1  NP_001186565.1  NP_001186566.1  

    ENSEMBL proteins: 
     ENSP00000306620   ENSP00000387335   ENSP00000400893   ENSP00000379514   ENSP00000386395  
     ENSP00000416622  
    Reactome Protein details: P41586
    Human Recombinant Protein Products: 
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    Uscn Proteins for ADCYAP1R1

    Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane ----
    GO:0005737cytoplasm ----
    GO:0005768endosome IEA--
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--


    ADCYAP1R1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADCYAP1R1

    Protein Domains /
    Families
    for ADCYAP1R1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADCYAP1R1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017983 GPCR_2_secretin-like_CS
     IPR001879 GPCR_2_extracellular_dom
     IPR017981 GPCR_2-like
     IPR002285 GPCR_2_PACAP_1_rcpt
     IPR000832 GPCR_2_secretin-like

    Graphical View of Domain Structure for InterPro Entry P41586

    ProtoNet protein and cluster: P41586

    2 Blocks protein families:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB002285 Pituitary adenylate cyclase activating polypeptide type 1 receptor signature


    UniProtKB/Swiss-Prot: PACR_HUMAN, P41586
    Similarity: Belongs to the G-protein coupled receptor 2 family


    Function
    for ADCYAP1R1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PACR_HUMAN, P41586
    Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which
    activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone,
    prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle
    relaxation and secretion in the gastrointestinal tract

         Genatlas biochemistry entry for ADCYAP1R1:
    pituitary adenylyl cyclase activating polypeptide receptor,with five splice variants among which four also activating
    phospholipase C and a sixth variant (PACAPR-TM4) activating L-type Ca++ channels,expressed in islet beta cells and
    involved in the physiological control of insulin release

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    hsa-miR-3678-3p hsa-miR-139-5p hsa-miR-29a hsa-miR-765 hsa-miR-764 hsa-miR-4267 hsa-miR-570 hsa-miR-149
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    Gene Editing
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001634pituitary adenylate cyclase-activating polypeptide receptor activity ----
    GO:0004872receptor activity TAS7902709
    GO:0004999vasoactive intestinal polypeptide receptor activity IEA--
    GO:0005515protein binding IPI17470806
    GO:0008179adenylate cyclase binding IEA--


    ADCYAP1R1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ADCYAP1R1: Adcyap1r1tm1Aba Adcyap1r1tm1Bbt Adcyap1r1tm1.1Gsc
         9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Adcyap1r1):
     behavior/neurological  growth/size  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  no phenotypic analysis  normal  reproductive system 

    ADCYAP1R1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADCYAP1R1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    2G beta:gamma signalling through PLC beta
    		Glucagon-type ligand receptors0.52
    		G alpha (s) signalling events0.14
    		Class B/2 (Secretin family receptors)0.20
    3NGF-independant TRKA activation
    		NGF-independant TRKA activation1.00
    		Activation of TRKA receptors0.83
    4Class A/1 (Rhodopsin-like receptors)
    		GPCR ligand binding0.75
    		Neuroactive ligand-receptor interaction0.38
    5Signaling by FGFR
    		NGF signalling via TRKA from the plasma membrane0.70
    		Signalling by NGF0.52

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for ADCYAP1R1
        PACAP Signaling

    2 BioSystems Pathways for ADCYAP1R1 
        SIDS Susceptibility Pathways
    GPCRs, Class B Secretin-like

    5/11        Reactome Pathways for ADCYAP1R1 (see all 11)
        GPCR downstream signaling
    Glucagon-type ligand receptors
    Signaling by GPCR
    GPCR ligand binding
    NGF signalling via TRKA from the plasma membrane


    1         Kegg Pathway  (Kegg details for ADCYAP1R1):
        Neuroactive ligand-receptor interaction


    ADCYAP1R1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADCYAP1R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/69 Interacting proteins for ADCYAP1R1 (P415862, 3 ENSP000003066204) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51636 I2D: score=3 
    CALM3P621582, 3MINT-51636 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51636 I2D: score=3 STRING: ENSP00000349467
    ADCYAP1P185093I2D: score=1 
    IGF1RP080693I2D: score=1 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7902709
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS--
    GO:0007190activation of adenylate cyclase activity TAS--
    GO:0007202activation of phospholipase C activity IEA--
    GO:0007275multicellular organismal development ----


    ADCYAP1R1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADCYAP1R1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADCYAP1R1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Compounds for ADCYAP1R1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PACAP 6-38Potent PAC1 receptor antagonist[143748-18-9]
    PACAP 1-38Potent stimulator of adenylyl cyclase--
    PACAP 1-27Potent stimulator of adenylyl cyclase[137061-48-4]
    4 Novoseek chemical compound relationships for ADCYAP1R1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pacap 38 82.7 2 7623776 (2)
    adenylate 80.4 13 7851900 (2), 10571263 (2), 7623776 (2), 10698193 (1) (see all 9)
    ribonucleic acid 37.4 1 10650947 (1)
    calcium 0 2 11941395 (2)

    Search CenterWatch for drugs/clinical trials and news about ADCYAP1R1 / PACR 

    Transcripts
    for ADCYAP1R1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADCYAP1R1 gene (4 alternative transcripts): 
    NM_001118.4  NM_001199635.1  NM_001199636.1  NM_001199637.1  

    Unigene Cluster for ADCYAP1R1:

    Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
    Hs.377783  [show with all ESTs]
    Unigene Representative Sequence: NM_001199635
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304166(uc003tcg.3 uc003tce.2 uc003tca.2 uc003tcb.2 uc003tcc.2)
    ENST00000409363 ENST00000431811 ENST00000396211 ENST00000409489(uc003tcf.1)
    ENST00000436116

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    hsa-miR-3678-3p hsa-miR-139-5p hsa-miR-29a hsa-miR-765 hsa-miR-764 hsa-miR-4267 hsa-miR-570 hsa-miR-149
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    Additional cDNA sequence: 

    AK096545.1 AK124304.1 AK226138.1 AK290046.1 AY366498.1 AY462278.1 AY462279.1 AY495951.1 
    AY495952.1 BC117116.1 BC136267.1 BC143679.1 BX538156.1 

    3 DOTS entries:

    DT.412226  DT.40237818  DT.101983437 

    24/97 AceView cDNA sequences (see all 97):

    CA432770 AW006247 BU501683 BG056056 AA319048 AY366498 AI655924 BQ071801 
    BM725146 AW451961 AY462279 AY495952 BQ935207 T33146 AY462278 AI363172 
    F10388 AA076766 AI361939 BF904755 AI815550 BX488413 AI418971 AY495951 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ADCYAP1R1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18
    SP1:                                                                                                        -     -                                             
    SP2:                                                                                                              -                                             
    SP3:                                                                                                                                                            
    SP4:        -                             -                                                                                                                     
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for ADCYAP1R1

    Expression
    for ADCYAP1R1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCYAP1R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTCCTGCCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADCYAP1R1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierAdult Endothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    BrainBlood Brain BarrierPostnatal Endothelial CellsBlood Brain Barrier, Endothelium
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Skeletal MuscleHyoid Arch MusclesMononuclear MyocytesSkeletal Muscle
    Skeletal MuscleMandibular Arch MusclesMononuclear MyocytesSkeletal Muscle
    BrainMedulla OblongataBrain
    Gut TubeMidgutGut Tube
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeMesencephalic Ventricular ZoneNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ADCYAP1R1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCYAP1R1

    SOURCE GeneReport for Unigene cluster: Hs.377783

    UniProtKB/Swiss-Prot: PACR_HUMAN, P41586
    Tissue specificity: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and
    placenta

        SABiosciences Expression via Pathway-Focused PCR Arrays including ADCYAP1R1: 
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    Orthologs
    for ADCYAP1R1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADCYAP1R1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADCYAP1R11 adenylate cyclase activating polypeptide 1 (pituitary) more 76.44(n)
    85.12(a)    		   420386  NM_001098606.1  NP_001092076.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADCYAP1R16
    SCTR6
    		 --
    		 78(a)
    49(a)
    		 1 ↔ 1
    possible ortholog
    		 6(2211733-2253813)
    GL343497.1(97461-109595)
    African clawed frog
    (Xenopus laevis)    		 Amphibia adcyap1r1-A2 adenylate cyclase activating polypeptide 1 (pituitary) more 80.72(n)    AF187878.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii adcyap1r1a1 adenylate cyclase activating polypeptide 1 receptor more 73.14(n)
    77.51(a)    		   541315  NM_001142926.1  NP_001136398.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    --
    (see all 4)    		 --
    		 4(a)
    24(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 Group9.2(517685-519657)
    GroupUn.2891(6917-15037)


    ENSEMBL Gene Tree for ADCYAP1R1 (if available)
    TreeFam Gene Tree for ADCYAP1R1 (if available) 

    Paralogs
    for ADCYAP1R1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCYAP1R1 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  CRHR22  PTH1R2  VIPR12  CRHR12  
    PTH2R2  CALCRL2  SCTR2  GLP2R2  VIPR22  GIPR2  
    10 SIMAP similar genes for ADCYAP1R1 using alignment to 8 protein entries:     PACR_HUMAN (see all proteins):
    VIPR2    VIPR1    GHRHR    SCTR    PTH1R    CRHR2
    CALCR    CALCRL    GIPR    PTHR2

    ADCYAP1R1 for paralogs           About GeneDecksing



    Genomic Variants
    for ADCYAP1R1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1045 NCBI SNPs in ADCYAP1R1 are shown (see all 1045)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1926822291,2
    		--31090357(+) GAAAGA/CGGCTC 4 -- us2k10--------
    rs1839674591,2
    		--31090650(+) CTCCAC/TGCGTC 4 -- us2k10--------
    rs1422217591,2
    		--31090920(+) GGCAGG/TGACCA 4 -- us2k10--------
    rs1422753011,2
    		C,--31090945(+) GGCAG-/GCAGGA
                GCAGG     		4 -- us2k10--------
    rs602941621,2
    		C,F,--31090968(+) ATGGGG/AGCTGG 4 -- us2k14Minor allele frequency- A:0.18WA EA 242
    rs1512206341,2
    		--31091154(+) TTATTC/GAGCAT 4 -- us2k10--------
    rs1156852041,2
    		F,--31091160(+) AGCATC/TGGCGA 4 -- us2k11Minor allele frequency- T:0.03WA 118
    rs354130741,2
    		C,F,H,--31091235(+) AAGAGA/CCCTGG 4 -- us2k119Minor allele frequency- C:0.23NS EA NA WA CSA 2341
    rs715574791,2
    		C,--31091413(+) GGGGCG/-GGGGG 4 -- us2k11Minor allele frequency- -:0.50NA 2
    rs1403375401,2
    		--31091594(+) GACCTA/CGGGAG 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCYAP1R1 (31092076 - 31151089 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADCYAP1R1: --

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    Disorders / Diseases
    for ADCYAP1R1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADCYAP1R1 for disorders           About GeneDecksing

    OMIM gene information: 102981    OMIM disorders: --

    18 diseases for ADCYAP1R1:    About MalaCards
    post-traumatic stress disorder    major depressive disorder    pituitary adenoma    neuroendocrine tumor
    hydrocephalus    copd    pheochromocytoma    adenoma
    hepatocellular carcinoma    psoriasis    lung cancer    prostate cancer
    sarcoma    cerebritis    neuroblastoma    prostatitis
    carcinoma    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: ADCYAP1R1 (2 documents)

    Export disorders for ADCYAP1R1 gene to outside databases

    Publications
    for ADCYAP1R1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCYAP1R1 gene, integrated from 9 sources (see all 80):
    (articles sorted by number of sources associating them with ADCYAP1R1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. (PubMed id 7902709)1, 2, 3, 9 Ogi K.... Fujino M. (1993)
    2. Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7. (PubMed id 7851900)1, 2, 9 Stoffel M.... Bell G.I. (1994)
    3. Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. (PubMed id 17470806)1, 2 Sun C....Olejniczak E.T. (2007)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. (PubMed id 10583729)1, 2 Dautzenberg F.M....Hauger R.L. (1999)
    6. Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta. (PubMed id 10698193)1, 9 Scaldaferri M.L....Moretti C. (2000)
    7. Regulatory mechanism of PAC1 gene expression via Sp1 b y nerve growth factor in PC12 cells. (PubMed id 22609358)1 Miura A....Miyata A. (2012)
    8. No association between ADCYAP1R1 and post-traumatic st ress disorder in two independent samples. (PubMed id 21912390)1 Chang S.C....Koenen K.C. (2012)
    9. Post-traumatic stress disorder is associated with PAC AP and the PAC1 receptor. (PubMed id 21350482)1 Ressler K.J....May V. (2011)
    10. Identification by photoaffinity labeling of the extra cellular N-terminal domain of PAC1 receptor as the major binding site for PACAP . (PubMed id 21185349)1 Dejda A....Fournier A. (2011)

    External Searches for ADCYAP1R1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ADCYAP1R1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117 HGNC: 242 AceView: ADCYAP1R1 Ensembl:ENSG00000078549 euGenes: HUgn117
    ECgene: ADCYAP1R1 Kegg: 117 H-InvDB: ADCYAP1R1

    Other Databases showing ADCYAP1R1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADCYAP1R1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCYAP1R1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADCYAP1R1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADCYAP1R1 gene:
    Search GeneIP for patents involving ADCYAP1R1

    GeneCards and IP:
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