Aliases for ADCYAP1R1 Gene
- ADCYAP Receptor Type I 2 3 5
- Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type I 2 3
- PACAP Type I Receptor 3 4
- PACAP Receptor 1 2 3
- PACAP-R1 3 4
- Pituitary Adenylate Cyclase Activating Polypeptide 1 Receptor Type I Hiphop 3
- Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor 3
External Ids for ADCYAP1R1 Gene
Previous GeneCards Identifiers for ADCYAP1R1 Gene
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
GeneCards Summary for ADCYAP1R1 Gene
ADCYAP1R1 (ADCYAP Receptor Type I) is a Protein Coding gene. Diseases associated with ADCYAP1R1 include Post-Traumatic Stress Disorder and Anxiety Disorder. Among its related pathways are Presynaptic function of Kainate receptors and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is VIPR1.
UniProtKB/Swiss-Prot for ADCYAP1R1 Gene
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.