Aliases for ADCYAP1R1 Gene
Aliases for ADCYAP1R1 Gene
- ADCYAP Receptor Type I 2 3 5
- Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type I 2 3
- PACAP Type I Receptor 3 4
- PACAP Receptor 1 2 3
- PACAP-R1 3 4
- Pituitary Adenylate Cyclase Activating Polypeptide 1 Receptor Type I Hiphop 3
- Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor 3
External Ids for ADCYAP1R1 Gene
- HGNC: 242
- Entrez Gene: 117
- Ensembl: ENSG00000078549
- OMIM: 102981
- UniProtKB: P41586
Previous GeneCards Identifiers for ADCYAP1R1 Gene
- GC07P030734
- GC07P030834
- GC07P030865
Summaries for ADCYAP1R1 Gene
-
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]
GeneCards Summary for ADCYAP1R1 Gene
ADCYAP1R1 (ADCYAP Receptor Type I) is a Protein Coding gene. Diseases associated with ADCYAP1R1 include Post-Traumatic Stress Disorder and Anxiety Disorder. Among its related pathways are Presynaptic function of Kainate receptors and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is VIPR1.
UniProtKB/Swiss-Prot for ADCYAP1R1 Gene
-
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
-
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCYAP1R1 Gene
Genomics for ADCYAP1R1 Gene
Regulatory Elements for ADCYAP1R1 Gene
Enhancers for ADCYAP1R1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH07G031026 | 0.8 | ENCODE dbSUPER | 19.9 | -24.1 | -24125 | 3.0 | MAZ SMARCA4 NRF1 FOXP2 ZIC2 EP300 | ADCYAP1R1 LOC105375221 |
| GH07G030988 | 1.3 | FANTOM5 ENCODE dbSUPER | 6.4 | -63.6 | -63649 | 1.1 | PKNOX1 ESRRA SIN3A KLF17 CEBPG BMI1 ZBTB7B CTBP1 POLR2A MAZ | ADCYAP1R1 LOC105375222 LOC105375221 |
| GH07G031122 | 0.7 | ENCODE | 11.1 | +70.4 | 70441 | 0.2 | CTCF TEAD4 MAX RAD21 FOSL1 SCRT2 ZNF143 SMC3 FOSL2 FOS | ADCYAP1R1 ENSG00000232887 PIR43889 |
| GH07G030892 | 1.7 | FANTOM5 Ensembl ENCODE dbSUPER | 3.6 | -156.9 | -156895 | 5.3 | SIN3A FEZF1 YY1 TCF12 ZNF121 GATA2 NCOA1 MBD2 SMARCA4 MYNN | ENSG00000250424 MINDY4 AQP1 ADCYAP1R1 OSBPL9P6 |
| GH07G030931 | 0.9 | ENCODE dbSUPER | 4.7 | -120.4 | -120394 | 2.7 | MIER1 TEAD4 NR3C1 REST NR2F2 EGR1 GLIS1 CREB1 KDM1A PRDM10 | ADCYAP1R1 GHRHR AQP1 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ADCYAP1R1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ADCYAP1R1 gene promoter:
Regulatory Element Products
Genomic Location for ADCYAP1R1 Gene
- Chromosome:
- 7
- Start:
- 31,052,341 bp from pter
- End:
- 31,111,479 bp from pter
- Size:
- 59,139 bases
- Orientation:
- Plus strand
Genomic View for ADCYAP1R1 Gene
Genes around ADCYAP1R1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7p14.3 by Ensembl
- 7p14.3 by Entrez Gene
- 7p14.3 by HGNC
ADCYAP1R1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADCYAP1R1 Gene
Proteins for ADCYAP1R1 Gene
-
Protein details for ADCYAP1R1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P41586-PACR_HUMAN
- Recommended name:
- Pituitary adenylate cyclase-activating polypeptide type I receptor
- Protein Accession:
- P41586
- A8K1Y1
- B7ZLA7
- B8ZZK3
- Q17S10
Protein attributes for ADCYAP1R1 Gene
- Size:
- 468 amino acids
- Molecular mass:
- 53314 Da
- Quaternary structure:
-
- Interacts (via N-terminal extracellular domain) with ADCYAP1.
- SequenceCaution:
-
- Sequence=BAA04466.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ADCYAP1R1 Gene
Post-translational modifications for ADCYAP1R1 Gene
Other Protein References for ADCYAP1R1 Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ADCYAP1R1
- Novus Biologicals Antibodies for ADCYAP1R1
- Invitrogen Antibodies for ADCYAP1R1
- antibodies-online Antibodies for ADCYAP1R1: See all 33
- GeneTex ADCYAP1R1 antibody for ADCYAP1R1
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADCYAP1R1
Protein Products
- EMD Millipore Purified and/or Recombinant ADCYAP1R1 Protein
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADCYAP1R1
- Origene Custom Protein Services for ADCYAP1R1
- Novus Biologicals proteins for ADCYAP1R1
- Sino Biological Cell Lysates for ADCYAP1R1
- Sino Biological Recombinant Proteins for ADCYAP1R1
- antibodies-online Proteins for ADCYAP1R1: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ADCYAP1R1
Assay Products
- antibodies-online Kits for ADCYAP1R1: See all 6
No data available for DME Specific Peptides for ADCYAP1R1 Gene
Domains & Families for ADCYAP1R1 Gene
Gene Families for ADCYAP1R1 Gene
Protein Domains for ADCYAP1R1 Gene
Suggested Antigen Peptide Sequences for ADCYAP1R1 Gene
- GenScript: Design optimal peptide antigens:
-
- ADCYAP1R1 protein (B7ZLA7_HUMAN)
- Pituitary adenylate cyclase-activating polypeptide type I receptor (PACR_HUMAN)
- Pituitary adenylate cyclase activating polypeptide 1 receptor type I HopII variant (Q6RKA2_HUMAN)
- Pituitary adenylate cyclase activating polypeptide 1 receptor type I Hip variant (Q6RKA3_HUMAN)
- Pituitary adenylate cyclase activating polypeptide 1 receptor type I Hop splice variant (Q6S991_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P41586- Family:
-
- Belongs to the G-protein coupled receptor 2 family.
Function for ADCYAP1R1 Gene
Molecular function for ADCYAP1R1 Gene
- GENATLAS Biochemistry:
- pituitary adenylyl cyclase activating polypeptide receptor,with five splice variants among which four also activating phospholipase C and a sixth variant (PACAPR-TM4) activating L-type Ca++ channels,expressed in islet beta cells and involved in the physiological control of insulin release
- UniProtKB/Swiss-Prot Function:
- This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004872 | receptor activity | TAS | 7902709 |
| GO:0004888 | transmembrane signaling receptor activity | IEA | -- |
| GO:0004930 | G-protein coupled receptor activity | IEA | -- |
| GO:0004999 | vasoactive intestinal polypeptide receptor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 17470806 |
Phenotypes for ADCYAP1R1 Gene
- MGI mutant phenotypes for ADCYAP1R1:
- inferred from 6 alleles
- GenomeRNAi human phenotypes for ADCYAP1R1:
Animal Models for ADCYAP1R1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADCYAP1R1
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADCYAP1R1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADCYAP1R1 gene
- Search ViGene Biosciences for ADCYAP1R1
CRISPR Products
-
OriGene CRISPR knockouts for ADCYAP1R1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCYAP1R1
- GenScript: Design CRISPR guide RNA sequences for ADCYAP1R1
miRNA for ADCYAP1R1 Gene
- miRTarBase miRNAs that target ADCYAP1R1
-
- hsa-mir-664a-3p (MIRT611486)
- hsa-mir-6074 (MIRT611487)
- hsa-mir-8485 (MIRT611488)
- hsa-mir-4789-3p (MIRT614418)
- hsa-mir-5096 (MIRT624798)
- hsa-mir-8063 (MIRT624799)
- hsa-mir-4801 (MIRT624800)
- hsa-mir-4731-3p (MIRT624801)
- hsa-mir-627-3p (MIRT628486)
- hsa-mir-3941 (MIRT636739)
- hsa-mir-603 (MIRT636740)
- hsa-mir-362-3p (MIRT636741)
- hsa-mir-329-3p (MIRT636742)
- hsa-mir-377-3p (MIRT639604)
- hsa-mir-190b (MIRT642159)
- hsa-mir-190a-5p (MIRT642160)
- hsa-mir-548o-3p (MIRT642161)
- hsa-mir-1323 (MIRT642162)
- hsa-mir-4480 (MIRT660879)
- hsa-mir-136-5p (MIRT660880)
- hsa-mir-365b-3p (MIRT660881)
- hsa-mir-365a-3p (MIRT660882)
- hsa-mir-8055 (MIRT660883)
- hsa-mir-4446-5p (MIRT660884)
- hsa-mir-5006-3p (MIRT660885)
- hsa-mir-4755-5p (MIRT660886)
- hsa-mir-211-5p (MIRT660887)
- hsa-mir-204-5p (MIRT660888)
- hsa-mir-623 (MIRT660889)
- hsa-mir-27b-5p (MIRT660890)
- hsa-mir-6832-3p (MIRT660891)
- hsa-mir-5088-3p (MIRT660892)
- hsa-mir-2114-5p (MIRT660893)
- hsa-mir-4311 (MIRT660894)
- hsa-mir-6758-3p (MIRT669616)
- hsa-mir-6827-3p (MIRT669617)
- hsa-mir-340-3p (MIRT669618)
miRNA Products
- Search ViGene Biosciences for ADCYAP1R1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ADCYAP1R1
- Browse OriGene Inhibitory RNA Products For ADCYAP1R1
-
ViGene Biosciences ready-to-package AAV shRNAs for ADCYAP1R1 gene
Clone Products
- Sino Biological Human cDNA Clone for ADCYAP1R1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ADCYAP1R1
- VectorBuilder custom plasmid, inducible vectors for ADCYAP1R1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCYAP1R1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ADCYAP1R1 (PAC1R)
Cell Line Products
-
Horizon Cell Lines for ADCYAP1R1
-
ViGene Biosciences adenoviral particle packaged cDNA for ADCYAP1R1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADCYAP1R1 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADCYAP1R1 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCYAP1R1 Gene
Localization for ADCYAP1R1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADCYAP1R1 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005791 | rough endoplasmic reticulum | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS | 7902709 |
Pathways & Interactions for ADCYAP1R1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Peptide ligand-binding receptors | ||
| 3 | Activation of TRKA receptors | ||
| 4 | Presynaptic function of Kainate receptors | ||
| 5 | RET signaling | ||
Pathways by source for ADCYAP1R1 Gene
2 BioSystems pathways for ADCYAP1R1 Gene
11 Reactome pathways for ADCYAP1R1 Gene
5 KEGG pathways for ADCYAP1R1 Gene
1 Qiagen pathway for ADCYAP1R1 Gene
Interacting Proteins for ADCYAP1R1 Gene
Selected Interacting proteins:
ENSP00000379514
P41586-PACR_HUMAN
for ADCYAP1R1 Gene via
STRING
MINT
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007165 | signal transduction | IEA | -- |
| GO:0007166 | cell surface receptor signaling pathway | TAS,IEA | -- |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | -- |
| GO:0007202 | activation of phospholipase C activity | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
Drugs & Compounds for ADCYAP1R1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| PACAP 6-38 | Pharma | Potent PAC1 receptor antagonist | 0 | |||
| [<sup>125</sup>I]PACAP-27 | Pharma | Agonist | 0 | |||
| [Ala<sup>11,22,28</sup>]VIP | Pharma | Agonist | 0 | |||
| [Arg<sup>16</sup>]chicken secretin | Pharma | Full agonist, Agonist | 0 | |||
| Bay 55-9837 | Pharma | Agonist | Potent and selective VPAC2 agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| [<sup>125</sup>I]VIP |
|
Full agonist, Agonist |
|
|
||
| [Lys<sup>15</sup>,Arg<sup>16</sup>,Leu<sup>27</sup>]VIP-(1?ao7)/GRF-(8?ao27)-NH<sub>2</sub> |
|
Full agonist, Agonist |
|
|
(1) Tocris Compounds for ADCYAP1R1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| PACAP 6-38 | Potent PAC1 receptor antagonist | 143748-18-9 |
(3) ApexBio Compounds for ADCYAP1R1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| PACAP 1-27 | 127317-03-7 | |
| PACAP 1-38 | 137061-48-4 | |
| PACAP 6-38 | 143748-18-9 |
Drug Products
- ApexBio compounds for ADCYAP1R1
Transcripts for ADCYAP1R1 Gene
mRNA/cDNA for ADCYAP1R1 Gene
- (9) REFSEQ mRNAs :
- (13) Additional mRNA sequences :
- (97) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ADCYAP1R1 Gene
- Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ADCYAP1R1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCYAP1R1
- GenScript: Design CRISPR guide RNA sequences for ADCYAP1R1
miRNA Products
- Search ViGene Biosciences for ADCYAP1R1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ADCYAP1R1
- Browse OriGene Inhibitory RNA Products For ADCYAP1R1
-
ViGene Biosciences ready-to-package AAV shRNAs for ADCYAP1R1 gene
Clone Products
- Sino Biological Human cDNA Clone for ADCYAP1R1
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ADCYAP1R1
- VectorBuilder custom plasmid, inducible vectors for ADCYAP1R1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCYAP1R1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- R&D Systems cDNA Clones for ADCYAP1R1 (PAC1R)
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ | 17a | · | 17b | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
Expression for ADCYAP1R1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Medulla Oblongata
- Cerebral Cortex
- Neural Tube (Nervous System)
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Adult Endothelial Cells Blood Brain Barrier
- Gut Tube (Gastrointestinal Tract)
- Inner Cell Mass (Early Embryonic Tissues)
- Oligodendrocytes (Nervous System)
- Spinal Cord (Nervous System)
mRNA differential expression in normal tissues according to GTEx for ADCYAP1R1 Gene
This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x4.9), Brain - Amygdala (x4.9), Brain - Caudate (basal ganglia) (x4.9), and Brain - Hypothalamus (x4.1).
This gene is overexpressed in Frontal cortex (27.6), Serum (26.5), and Spinal cord (14.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCYAP1R1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADCYAP1R1 Gene:
ADCYAP1R1SOURCE GeneReport for Unigene cluster for ADCYAP1R1 Gene:
Hs.377783mRNA Expression by UniProt/SwissProt for ADCYAP1R1 Gene:
P41586-PACR_HUMAN
Tissue specificity:
Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta.
Evidence on tissue expression from TISSUES for ADCYAP1R1 Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs for ADCYAP1R1
-
OriGene qPCR primer pairs and template standards for ADCYAP1R1
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCYAP1R1 Gene
Orthologs for ADCYAP1R1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADCYAP1R1 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ADCYAP1R1 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ADCYAP1R1 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adcyap1r1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Adcyap1r1 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADCYAP1R1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADCYAP1R1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADCYAP1R1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADCYAP1R1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adcyap1r1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | adcyap1r1-A 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ADCYAP1R1 (2 of 2) 35 |
|
OneToMany | |
| adcyap1r1a 34 35 |
|
- Species where no ortholog for ADCYAP1R1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ADCYAP1R1 Gene
Paralogs for ADCYAP1R1 Gene
(8) SIMAP similar genes for ADCYAP1R1 Gene using alignment to 8 proteins:
Variants for ADCYAP1R1 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000026227 | -- | 31,112,330(+) | GGAAA(C/T)TGGAC | utr-variant-3-prime | |
| rs1000026979 | -- | 31,072,725(+) | GCCCA(A/C)GTCAT | intron-variant | |
| rs1000058285 | -- | 31,066,656(+) | CGTAC(C/T)CCAGC | intron-variant | |
| rs1000220339 | -- | 31,088,724(+) | TATTT(G/T)TCCAT | intron-variant | |
| rs1000276665 | -- | 31,095,366(+) | GATAG(C/T)ATTAA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv11257n54 | CNV | loss | 21841781 |
| dgv6316n100 | CNV | gain | 25217958 |
| esv2761316 | CNV | gain | 21179565 |
| nsv1023274 | CNV | gain | 25217958 |
| nsv1068321 | OTHER | inversion | 25765185 |
| nsv1128308 | CNV | deletion | 24896259 |
| nsv1148830 | OTHER | inversion | 26484159 |
| nsv436557 | CNV | deletion | 17901297 |
| nsv464418 | CNV | loss | 19166990 |
| nsv519081 | CNV | loss | 19592680 |
| nsv527038 | CNV | gain | 19592680 |
| nsv5685 | CNV | insertion | 18451855 |
Residual Variation Intolerance Score:
20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.78;
33.58% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ADCYAP1R1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCYAP1R1 Gene
Disorders for ADCYAP1R1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| post-traumatic stress disorder |
|
|
| anxiety disorder |
|
|
Search ADCYAP1R1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ADCYAP1R1
No data available for UniProtKB/Swiss-Prot and Genatlas for ADCYAP1R1 Gene
Publications for ADCYAP1R1 Gene
- Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. (PMID: 7902709) Ogi K. … Fujino M. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 22 64
- Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7. (PMID: 7851900) Stoffel M. … Bell G.I. (Genomics 1994) 3 4 22 64
- Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. (PMID: 21621269) Aragam N. … Pan Y. (J Affect Disord 2011) 3 46 64
- Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PMID: 19086053) GratacA^s M. … Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 46 64
- Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. (PMID: 17470806) Sun C. … Olejniczak E.T. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3 4 64
Products for ADCYAP1R1 Gene
- Browse Small Molecules at EMD Millipore
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ADCYAP1R1
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- antibodies-online Antibodies for ADCYAP1R1: See all 33
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- antibodies-online Proteins for ADCYAP1R1: See all 3
- Search antibodies-online for peptides
- GeneTex ADCYAP1R1 antibody for ADCYAP1R1
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- ViGene Biosciences adenoviral particle packaged cDNA for ADCYAP1R1 gene
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- Santa Cruz Biotechnology (SCBT) CRISPR for ADCYAP1R1
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- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ADCYAP1R1 Gene
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