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ADCYAP1R1 Gene

protein-coding   GIFtS: 63
GCID: GC07P031058

Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type
I1 2
     PAC1R2
PACAP Receptor 11 2     PACAPRI2
PACAP-R12 3     Pituitary Adenylate Cyclase Activating Polypeptide 1 Receptor Type I
Hiphop2
PACAP Type I Receptor2 3     Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor2
PACAPR2 5     PACAP-R-13
PAC12     

External Ids:    HGNC: 2421   Entrez Gene: 1172   Ensembl: ENSG000000785497   OMIM: 1029815   UniProtKB: P415863   

Export aliases for ADCYAP1R1 gene to outside databases

Previous GC identifers: GC07P030734 GC07P030834 GC07P030865


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCYAP1R1 Gene:
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein
and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates
diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate
cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified.
(provided by RefSeq, Dec 2010)

GeneCards Summary for ADCYAP1R1 Gene:
ADCYAP1R1 (adenylate cyclase activating polypeptide 1 (pituitary) receptor type I) is a protein-coding gene. Diseases associated with ADCYAP1R1 include post-traumatic stress disorder, and hydrocephalus. GO annotations related to this gene include receptor activity and ADP-ribosylation factor binding. An important paralog of this gene is GLP1R.

UniProtKB/Swiss-Prot: PACR_HUMAN, P41586
Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins
which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth
hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes
smooth muscle relaxation and secretion in the gastrointestinal tract

summary for ADCYAP1R1 Gene:
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors
referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1
receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb,
thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the
adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock,
emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human
PAC1 receptor gene has been localized to chromosome 7p14.

Gene Wiki entry for ADCYAP1R1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCYAP1R1 gene promoter:
         RP58   p53   Bach2   Nkx2-5   LCR-F1   FOXL1   C/EBPalpha   HEN1   FAC1   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ADCYAP1R1 promoter sequence
   Search Chromatin IP Primers for ADCYAP1R1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCYAP1R1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p14   Ensembl cytogenetic band:  7p14.3   HGNC cytogenetic band: 7p14.3

ADCYAP1R1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCYAP1R1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P031058:  view genomic region     (about GC identifiers)

Start:
31,092,076 bp from pter      End:
31,151,093 bp from pter
Size:
59,018 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 31,141,254-31,200,271     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PACR_HUMAN, P41586 (See protein sequence)
Recommended Name: Pituitary adenylate cyclase-activating polypeptide type I receptor precursor  
Size: 468 amino acids; 53314 Da
Subunit: Interacts (via N-terminal extracellular domain) with ADCYAP1
Sequence caution: Sequence=BAA04466.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for ADCYAP1R1:
2JOD (3D)        3N94 (3D)    
Secondary accessions: A8K1Y1 B7ZLA7 B8ZZK3 Q17S10
Alternative splicing: 5 isoforms:  P41586-1   P41586-2   P41586-3   P41586-4   P41586-5   (Ref.7 (AAI43680) sequence is in conflict in position: 350:S->Missing)

Explore the universe of human proteins at neXtProt for ADCYAP1R1: NX_P41586

Explore proteomics data for ADCYAP1R1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn48, Asn60, Asn117, Asn300, Asn375
  • Modification sites at PhosphoSitePlus

  • See ADCYAP1R1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001109.2  NP_001186564.1  NP_001186565.1  NP_001186566.1  

    ENSEMBL proteins: 
     ENSP00000306620   ENSP00000387335   ENSP00000400893   ENSP00000379514   ENSP00000386395  
     ENSP00000416622  
    Reactome Protein details: P41586

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    VIPPACR: GPCR / Class B : VIP and PACAP (ADCYAP1) receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: PAC1 receptor
    VIP and PACAP receptors

    5 InterPro protein domains:
     IPR001879 GPCR_2_extracellular_dom
     IPR000832 GPCR_2_secretin-like
     IPR017983 GPCR_2_secretin-like_CS
     IPR017981 GPCR_2-like
     IPR002285 GPCR_2_PACAP_1_rcpt

    Graphical View of Domain Structure for InterPro Entry P41586

    ProtoNet protein and cluster: P41586

    2 Blocks protein domains:
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB002285 Pituitary adenylate cyclase activating polypeptide type 1 receptor signature


    UniProtKB/Swiss-Prot: PACR_HUMAN, P41586
    Similarity: Belongs to the G-protein coupled receptor 2 family


    ADCYAP1R1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PACR_HUMAN, P41586
    Function: This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins
    which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth
    hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes
    smooth muscle relaxation and secretion in the gastrointestinal tract

         Genatlas biochemistry entry for ADCYAP1R1:
    pituitary adenylyl cyclase activating polypeptide receptor,with five splice variants among which four also
    activating phospholipase C and a sixth variant (PACAPR-TM4) activating L-type Ca++ channels,expressed in islet
    beta cells and involved in the physiological control of insulin release

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7902709
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity ----
    GO:0004999vasoactive intestinal polypeptide receptor activity IEA--
    GO:0005515protein binding IPI17470806
         
    ADCYAP1R1 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Adcyap1r1):
     behavior/neurological  growth/size/body  homeostasis/metabolism  immune system  mortality/aging 
     nervous system  no phenotypic analysis  normal  reproductive system 

    ADCYAP1R1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADCYAP1R1: Adcyap1r1tm1Aba Adcyap1r1tm1Bbt Adcyap1r1tm1.1Gsc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADCYAP1R1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCYAP1R1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCYAP1R1

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    Selected qRT-PCR Assays for microRNAs that regulate ADCYAP1R1 (see all 42):
    hsa-miR-3678-3p hsa-miR-139-5p hsa-miR-29a hsa-miR-765 hsa-miR-764 hsa-miR-4267 hsa-miR-570 hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCYAP1R1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PACR_HUMAN, P41586: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2
    endosome2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005768endosome IEA--
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7902709

    ADCYAP1R1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCYAP1R1 About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    4ADP signalling through P2Y purinoceptor 12
    Glucagon-type ligand receptors0.61
    Class B/2 (Secretin family receptors)0.36
    5Activation of TRKA receptors
    Activation of TRKA receptors
    NGF-independant TRKA activation0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ADCYAP1R1
        PACAP Signaling

    2 BioSystems Pathways for ADCYAP1R1
        SIDS Susceptibility Pathways
    GPCRs, Class B Secretin-like


    3 Reactome Pathways for ADCYAP1R1
        Glucagon-type ligand receptors
    G alpha (s) signalling events
    NGF-independant TRKA activation


    3 Kegg Pathways  (Kegg details for ADCYAP1R1):
        Neuroactive ligand-receptor interaction
    Circadian entrainment
    Insulin secretion


    ADCYAP1R1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADCYAP1R1: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Neurotrophins & Receptors in human mouse rat
              Obesity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADCYAP1R1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCYAP1R1 (P415862, 3 ENSP000003066204) via UniProtKB, MINT, STRING, and/or I2D (see all 71)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM2P621582, 3MINT-51636 I2D: score=3 
    CALM3P621582, 3MINT-51636 I2D: score=3 
    CALM1P621582, 3, ENSP000003494674MINT-51636 I2D: score=3 STRING: ENSP00000349467
    IGF1RP080693, ENSP000002680354I2D: score=1 STRING: ENSP00000268035
    ADCYAP1P185093I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS7902709
    GO:0007169transmembrane receptor protein tyrosine kinase signaling pathway TAS--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007190activation of adenylate cyclase activity TAS--
    GO:0007202activation of phospholipase C activity IEA--

    ADCYAP1R1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Compounds for ADCYAP1R1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PACAP 6-38Potent PAC1 receptor antagonist[143748-18-9]
    PACAP 1-38Potent stimulator of adenylyl cyclase[137061-48-4]

    Selected IUPHAR Ligands for ADCYAP1R1 (PAC1 receptor) (see all 15)    About this table
    LigandTypeActionAffinityPubmed IDs
    maxadilan
    AgonistAgonist10.316930633
    PACAP-38
    AgonistAgonist10.316930633
    [125I]PACAP-27
    AgonistAgonist9.111193823
    PACAP-27
    AgonistAgonist8.510583729
    N-stearyl-[Nle17] neurotensin-(6-11)/VIP-(7-28)
    AntagonistAntagonist7.211931347
    PG 99-465
    AgonistAgonist7.116930633
    M65
    AntagonistAntagonist6.816930633
    VIP
    AgonistAgonist6.310583729
    Ro 25-1553
    AgonistAgonist611931347
    [Ala11,22,28]VIP
    AgonistAgonist5.816930633

    4 Novoseek inferred chemical compound relationships for ADCYAP1R1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pacap 38 82.7 2 7623776 (2)
    adenylate 80.4 13 7851900 (2), 10571263 (2), 7623776 (2), 10698193 (1) (see all 9)
    ribonucleic acid 37.4 1 10650947 (1)
    calcium 0 2 11941395 (2)



    ADCYAP1R1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADCYAP1R1 gene (4 alternative transcripts): 
    NM_001118.4  NM_001199635.1  NM_001199636.1  NM_001199637.1  

    Unigene Cluster for ADCYAP1R1:

    Adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
    Hs.377783  [show with all ESTs]
    Unigene Representative Sequence: NM_001199635
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304166(uc003tcg.3 uc003tce.2 uc003tca.2 uc003tcb.2 uc003tcc.2)
    ENST00000409363 ENST00000431811 ENST00000396211 ENST00000409489(uc003tcf.1)
    ENST00000436116
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      QuantiTect SYBR Green Assays in human, mouse, rat ADCYAP1R1
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    Additional mRNA sequence: 

    AK096545.1 AK124304.1 AK226138.1 AK290046.1 AY366498.1 AY462278.1 AY462279.1 AY495951.1 
    AY495952.1 BC117116.1 BC136267.1 BC143679.1 BX538156.1 

    3 DOTS entries:

    DT.412226  DT.40237818  DT.101983437 

    Selected AceView cDNA sequences (see all 97):

    AY366498 BU501604 BM725146 AI094596 CA432770 AA878453 AA076766 AI419703 
    BX488413 NM_001118 AW512246 T33146 AI815550 F10388 AI418971 BF904755 
    AI655924 AY495951 AY462278 AA319048 AW451961 BQ071801 N52753 AW006247 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADCYAP1R1 (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b ^ 18
    SP1:                                                                                                        -     -                                             
    SP2:                                                                                                              -                                             
    SP3:                                                                                                                                                            
    SP4:        -                             -                                                                                                                     
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for ADCYAP1R1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADCYAP1R1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCCTGCCT
    ADCYAP1R1 Expression
    About this image


    ADCYAP1R1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
             Oligodendrocyte progenitor cells
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Metencephalon
     
     Endothelium (Cardiovascular System)    fully expand to see all 3 entries
             Adult Endothelial Cells Blood Brain Barrier
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
    ADCYAP1R1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCYAP1R1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.377783

    UniProtKB/Swiss-Prot: PACR_HUMAN, P41586
    Tissue specificity: Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and
    placenta

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ADCYAP1R1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcyap1r11 , 5 adenylate cyclase activating polypeptide 1 receptor more1, 5 88.91(n)1
    93.15(a)1
      6 (27.38 cM)5
    115171  NM_007407.41  NP_031433.31 
     554519785 
    chicken
    (Gallus gallus)
    Aves ADCYAP1R11 adenylate cyclase activating polypeptide 1 (pituitary) more 76.81(n)
    85.68(a)
      420386  NM_001098606.1  NP_001092076.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADCYAP1R16
    adenylate cyclase activating polypeptide 1 (pituit...
    77(a)
    1 ↔ 1
    6(2171773-2253813)
    African clawed frog
    (Xenopus laevis)
    Amphibia adcyap1r1-A2 adenylate cyclase activating polypeptide 1 (pituitary) more 80.72(n)    AF187878.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adcyap1r1a1 adenylate cyclase activating polypeptide 1 receptor more 74.16(n)
    79.33(a)
      541315  NM_001013444.2  NP_001013462.1 


    ENSEMBL Gene Tree for ADCYAP1R1 (if available)
    TreeFam Gene Tree for ADCYAP1R1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADCYAP1R1 gene
    GLP1R2  GHRHR2  GCGR2  CALCR2  PTH1R2  CRHR22  VIPR12  CRHR12  
    PTH2R2  CALCRL2  SCTR2  GLP2R2  VIPR22  GIPR2  
    8 SIMAP similar genes for ADCYAP1R1 using alignment to 8 protein entries:     PACR_HUMAN (see all proteins):
    VIPR2    VIPR1    GHRHR    SCTR    CALCR    PTH1R
    CRHR2    CALCRL

    ADCYAP1R1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADCYAP1R1 (see all 1301)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347310401,2
    C--30976863(+) GGAAAGTGT/-  
            
    GTGTG
    4 -- int11Minor allele frequency- -:0.50NA 2
    rs114084371,2
    C--30987617(+) GGGCCC/-AGAAG 4 -- int13Minor allele frequency- -:0.00NA CSA 6
    rs1926822291,2
    --31068081(+) GAAAGA/CGGCTC 4 -- us2k10--------
    rs624500691,2
    C,F--31068147(+) GAGGTC/TCTGTC 4 -- us2k13Minor allele frequency- T:0.16NA 124
    rs1839674591,2
    --31068374(+) CTCCAC/TGCGTC 4 -- us2k10--------
    rs1422217591,2
    --31068644(+) GGCAGG/TGACCA 4 -- us2k10--------
    rs1422753011,2
    C--31068669(+) GGCAG-/GCAGGA
            
    GCAGG
    4 -- cds10--------
    rs602941621,2
    C,F--31068692(+) ATGGGG/AGCTGG 4 -- us2k14Minor allele frequency- A:0.18WA EA 242
    rs1512206341,2
    --31068878(+) TTATTC/GAGCAT 4 -- us2k10--------
    rs1156852041,2
    C,F--31068884(+) AGCATC/TGGCGA 4 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for ADCYAP1R1 (31092076 - 31151093 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ADCYAP1R1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv436557CNV Deletion17901297
    nsv5685CNV Insertion18451855
    nsv519081CNV Loss19592680
    nsv464418CNV Loss19166990
    nsv527038CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADCYAP1R1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADCYAP1R1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 102981    OMIM disorders: --

    19 diseases for ADCYAP1R1:    
    About MalaCards
    post-traumatic stress disorder    hydrocephalus    major depressive disorder    neuroendocrine tumor
    pituitary adenoma    pheochromocytoma    psoriasis    adenoma
    neuroblastoma    obesity    asthma    cerebritis
    sarcoma    hepatocellular carcinoma    lung cancer    prostate cancer
    prostatitis    neuronitis    endotheliitis


    ADCYAP1R1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADCYAP1R1
    Human Genome Epidemiology (HuGE) Navigator: ADCYAP1R1 (2 documents)

    Export disorders for ADCYAP1R1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADCYAP1R1 gene, integrated from 10 sources (see all 92):
    (articles sorted by number of sources associating them with ADCYAP1R1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor. (PubMed id 7902709)1, 2, 3, 9 Ogi K.... Fujino M. (Biochem. Biophys. Res. Commun. 1993)
    2. Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical and genetic map of chromosome 7. (PubMed id 7851900)1, 2, 9 Stoffel M.... Bell G.I. (Genomics 1994)
    3. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. (PubMed id 21621269)1, 4 Aragam N....Pan Y. (J Affect Disord 2011)
    4. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    5. Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. (PubMed id 17470806)1, 2 Sun C.... Olejniczak E.T. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. N-terminal splice variants of the type I PACAP receptor: isolation, characterization and ligand binding/selectivity determinants. (PubMed id 10583729)1, 2 Dautzenberg F.M.... Hauger R.L. (J. Neuroendocrinol. 1999)
    8. Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta. (PubMed id 10698193)1, 9 Scaldaferri M.L....Moretti C. (Endocrinology 2000)
    9. Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment. (PubMed id 23280952)1 Uddin M....Koenen K.C. (Depress Anxiety 2013)
    10. PACAP and the PAC1 receptor in post-traumatic stress disorder. (PubMed id 23147486)1 Dias B.G. and Ressler K.J. (Neuropsychopharmacology 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 117 HGNC: 242 AceView: ADCYAP1R1 Ensembl:ENSG00000078549 euGenes: HUgn117
    ECgene: ADCYAP1R1 Kegg: 117 H-InvDB: ADCYAP1R1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADCYAP1R1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADCYAP1R1 gene:
    Search GeneIP for patents involving ADCYAP1R1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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