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Aliases for ADCYAP1 Gene

Aliases for ADCYAP1 Gene

  • Adenylate Cyclase Activating Polypeptide 1 (Pituitary) 2 3
  • Prepro-PACAP 2 3
  • PACAP 3 4
  • Pituitary Adenylate Cyclase-Activating Polypeptide 3

External Ids for ADCYAP1 Gene

Previous GeneCards Identifiers for ADCYAP1 Gene

  • GC18M001066
  • GC18P000892

Summaries for ADCYAP1 Gene

Entrez Gene Summary for ADCYAP1 Gene

  • This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

GeneCards Summary for ADCYAP1 Gene

ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1 (Pituitary)) is a Protein Coding gene. Diseases associated with ADCYAP1 include post-traumatic stress disorder and chronic fatigue syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include receptor binding and neuropeptide hormone activity. An important paralog of this gene is VIP.

UniProtKB/Swiss-Prot for ADCYAP1 Gene

  • Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

Tocris Summary for ADCYAP1 Gene

  • Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock, emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human PAC1 receptor gene has been localized to chromosome 7p14.

Gene Wiki entry for ADCYAP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCYAP1 Gene

Genomics for ADCYAP1 Gene

Regulatory Elements for ADCYAP1 Gene

Genomic Location for ADCYAP1 Gene

Start:
904,365 bp from pter
End:
912,172 bp from pter
Size:
7,808 bases
Orientation:
Plus strand

Genomic View for ADCYAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCYAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCYAP1 Gene

Proteins for ADCYAP1 Gene

  • Protein details for ADCYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18509-PACA_HUMAN
    Recommended name:
    Pituitary adenylate cyclase-activating polypeptide
    Protein Accession:
    P18509
    Secondary Accessions:
    • B2R7N4
    • Q52LQ0

    Protein attributes for ADCYAP1 Gene

    Size:
    176 amino acids
    Molecular mass:
    18835 Da
    Quaternary structure:
    • Interacts with ADCYAP1R1 (via N-terminal extracellular domain).

    Three dimensional structures from OCA and Proteopedia for ADCYAP1 Gene

neXtProt entry for ADCYAP1 Gene

Proteomics data for ADCYAP1 Gene at MOPED

Post-translational modifications for ADCYAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCYAP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ADCYAP1 Gene

Domains for ADCYAP1 Gene

Gene Families for ADCYAP1 Gene

HGNC:

Protein Domains for ADCYAP1 Gene

Graphical View of Domain Structure for InterPro Entry

P18509

UniProtKB/Swiss-Prot:

PACA_HUMAN :
  • P18509
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with ADCYAP1: view

Function for ADCYAP1 Gene

Molecular function for ADCYAP1 Gene

GENATLAS Biochemistry: pituitary adenylyl cyclase activating polypeptide (glucagon,VIP family),including 2 isoforms PACAP27 and PACAP38,expressed in the retinohypothalamus tract (RHT),acting as a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock
UniProtKB/Swiss-Prot Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

Gene Ontology (GO) - Molecular Function for ADCYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005102 receptor binding IPI 7680413
GO:0005179 hormone activity --
GO:0005184 neuropeptide hormone activity IDA 23800469
GO:0005515 protein binding IPI 25451228
genes like me logo Genes that share ontologies with ADCYAP1: view
genes like me logo Genes that share phenotypes with ADCYAP1: view

Animal Models for ADCYAP1 Gene

MGI Knock Outs for ADCYAP1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ADCYAP1 Gene

Localization for ADCYAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCYAP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCYAP1 Gene COMPARTMENTS Subcellular localization image for ADCYAP1 gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADCYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with ADCYAP1: view

Pathways for ADCYAP1 Gene

genes like me logo Genes that share pathways with ADCYAP1: view

Pathways by source for ADCYAP1 Gene

1 Qiagen pathway for ADCYAP1 Gene
1 BioSystems pathway for ADCYAP1 Gene

Gene Ontology (GO) - Biological Process for ADCYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001662 behavioral fear response IEA --
GO:0001821 histamine secretion IEA --
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus IEA --
GO:0002878 negative regulation of acute inflammatory response to non-antigenic stimulus IEA --
genes like me logo Genes that share ontologies with ADCYAP1: view

Compounds for ADCYAP1 Gene

(1) Tocris Compounds for ADCYAP1 Gene

Compound Action Cas Number
PACAP 6-38 Potent PAC1 receptor antagonist [143748-18-9]

(1) Drugbank Compounds for ADCYAP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2,6-Diamino-Hexanoic Acid Amide
target

(112) Novoseek inferred chemical compound relationships for ADCYAP1 Gene

Compound -log(P) Hits PubMed IDs
pacap 38 96.5 146
adenylate 96.4 216
pacaps 91.3 9
helospectin 81.2 12
forskolin 74.2 47
genes like me logo Genes that share compounds with ADCYAP1: view

Transcripts for ADCYAP1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADCYAP1 Gene

No ASD Table

Relevant External Links for ADCYAP1 Gene

GeneLoc Exon Structure for
ADCYAP1
ECgene alternative splicing isoforms for
ADCYAP1

Expression for ADCYAP1 Gene

mRNA expression in normal human tissues for ADCYAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCYAP1 Gene

This gene is overexpressed in Brain - Hypothalamus (10.9), Brain - Anterior cingulate cortex (BA24) (4.8), and Brain - Frontal Cortex (BA9) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCYAP1 Gene

SOURCE GeneReport for Unigene cluster for ADCYAP1 Gene Hs.531719

genes like me logo Genes that share expressions with ADCYAP1: view

No data available for mRNA Expression by UniProt/SwissProt for ADCYAP1 Gene

Orthologs for ADCYAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADCYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCYAP1 35
  • 94.89 (n)
  • 90.34 (a)
PACAP 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCYAP1 35
  • 82.95 (n)
  • 77.27 (a)
ADCYAP1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCYAP1 35
  • 89.39 (n)
  • 85.8 (a)
mouse
(Mus musculus)
Mammalia Adcyap1 35
  • 85.52 (n)
  • 82.86 (a)
Adcyap1 16
Adcyap1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCYAP1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCYAP1 36
  • 36 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcyap1 35
  • 85.52 (n)
  • 82.29 (a)
chicken
(Gallus gallus)
Aves ADCYAP1 35
  • 76.61 (n)
  • 69.59 (a)
ADCYAP1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCYAP1 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia PACAP 35
tropical clawed frog
(Silurana tropicalis)
Amphibia adcyap1 35
  • 69.34 (n)
  • 66.42 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8047 35
zebrafish
(Danio rerio)
Actinopterygii adcyap1a 36
  • 41 (a)
OneToMany
adcyap1b 36
  • 55 (a)
OneToMany
Dr.10739 35
Species with no ortholog for ADCYAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADCYAP1 Gene

ENSEMBL:
Gene Tree for ADCYAP1 (if available)
TreeFam:
Gene Tree for ADCYAP1 (if available)

Paralogs for ADCYAP1 Gene

Paralogs for ADCYAP1 Gene

Selected SIMAP similar genes for ADCYAP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADCYAP1: view

Variants for ADCYAP1 Gene

Sequence variations from dbSNP and Humsavar for ADCYAP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs928978 -- 908,534(+) CTTTA(A/C)ATTTG intron-variant
rs928979 -- 908,765(+) CAAAT(G/T)TGGAC intron-variant
rs928980 -- 908,776(+) ACTTA(C/T)GGACC intron-variant
rs940196 -- 908,827(+) GCTTG(C/T)GTGAA intron-variant
rs1006567 -- 910,567(-) GGGTC(C/G)TCCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADCYAP1 Gene

Variant ID Type Subtype PubMed ID
nsv909288 CNV Loss 21882294
nsv528169 CNV Loss 19592680
nsv518677 CNV Loss 19592680
nsv517252 CNV Loss 19592680

Relevant External Links for ADCYAP1 Gene

HapMap Linkage Disequilibrium report
ADCYAP1
Human Gene Mutation Database (HGMD)
ADCYAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCYAP1 Gene

Disorders for ADCYAP1 Gene

(2) University of Copenhagen DISEASES for ADCYAP1 Gene

(71) Novoseek inferred disease relationships for ADCYAP1 Gene

Disease -log(P) Hits PubMed IDs
gulf war syndrome 56.3 1
pituitary adenoma 37.1 15
pituitary adenoma nonfunctioning 33.9 1
pheochromocytoma 33.9 7
sudden infant death syndrome 33 4

Relevant External Links for ADCYAP1

Genetic Association Database (GAD)
ADCYAP1
Human Genome Epidemiology (HuGE) Navigator
ADCYAP1
genes like me logo Genes that share disorders with ADCYAP1: view

No data available for UniProtKB/Swiss-Prot for ADCYAP1 Gene

Publications for ADCYAP1 Gene

  1. Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (PMID: 1730060) Hosoya M. … Fujino M. (Biochim. Biophys. Acta 1992) 2 3 4 23
  2. Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide. (PMID: 1739432) Ohkubo S. … Fujino M. (DNA Cell Biol. 1992) 3 4 23
  3. Association analysis of the pituitary adenyl cyclase activating peptide gene (PACAP) on chromosome 18p11 with schizophrenia and bipolar disorders. (PMID: 11515750) Ishiguro H. … Arinami T. (J Neural Transm 2001) 3 23 48
  4. Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution. (PMID: 1483839) Inooka H. … Fujino M. (Int. J. Pept. Protein Res. 1992) 3 4 23
  5. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. (PMID: 2302217) Kimura C. … Fujino M. (Biochem. Biophys. Res. Commun. 1990) 3 4 23

Products for ADCYAP1 Gene

Sources for ADCYAP1 Gene

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