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ADCYAP1 Gene

protein-coding   GIFtS: 62
GCID: GC18P000895

Adenylate Cyclase Activating Polypeptide 1 (Pituitary)

  See ADCYAP1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase Activating Polypeptide 1 (Pituitary)1 2
prepro-PACAP1 2
PACAP2 3
Pituitary Adenylate Cyclase-Activating Polypeptide2

External Ids:    HGNC: 2411   Entrez Gene: 1162   Ensembl: ENSG000001414337   OMIM: 1029805   UniProtKB: P185093   

Export aliases for ADCYAP1 gene to outside databases

Previous GC identifers: GC18M001066 GC18P000892


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCYAP1 Gene:
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides
stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the
transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress
responses. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2013)

GeneCards Summary for ADCYAP1 Gene:
ADCYAP1 (adenylate cyclase activating polypeptide 1 (pituitary)) is a protein-coding gene. Diseases associated with ADCYAP1 include post-traumatic stress disorder, and carpal tunnel syndrome. GO annotations related to this gene include neuropeptide hormone activity and receptor binding. An important paralog of this gene is VIP.

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509
Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.
Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway

summary for ADCYAP1 Gene:
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors
referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1
receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb,
thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the
adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock,
emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human
PAC1 receptor gene has been localized to chromosome 7p14.

Gene Wiki entry for ADCYAP1 (Pituitary adenylate cyclase-activating peptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010859.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCYAP1 gene promoter:
         CREB   GR   AP-1   deltaCREB   ATF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCYAP1 promoter sequence
   Search Chromatin IP Primers for ADCYAP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCYAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11

ADCYAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCYAP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P000895:  view genomic region     (about GC identifiers)

Start:
904,944 bp from pter      End:
912,173 bp from pter
Size:
7,230 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: PACA_HUMAN, P18509 (See protein sequence)
Recommended Name: Pituitary adenylate cyclase-activating polypeptide precursor  
Size: 176 amino acids; 18835 Da
Subunit: Interacts with ADCYAP1R1 (via N-terminal extracellular domain)
3 PDB 3D structures from and Proteopedia for ADCYAP1:
1GEA (3D)        2D2P (3D)        2JOD (3D)    
Secondary accessions: B2R7N4 Q52LQ0

Explore the universe of human proteins at neXtProt for ADCYAP1: NX_P18509

Explore proteomics data for ADCYAP1 at MOPED


See ADCYAP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts): 
NP_001093203.1  NP_001108.2  

ENSEMBL proteins: 
 ENSP00000411658   ENSP00000462647  
Reactome Protein details: P18509

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

1 InterPro protein domain:
 IPR000532 Glucagon_GIP_secretin_VIP

Graphical View of Domain Structure for InterPro Entry P18509

ProtoNet protein and cluster: P18509

1 Blocks protein domain: IPB000532 Glucagon/GIP/secretin/VIP

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509
Similarity: Belongs to the glucagon family


Find genes that share domains with ADCYAP1           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: PACA_HUMAN, P18509
Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.
Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway

     Genatlas biochemistry entry for ADCYAP1:
pituitary adenylyl cyclase activating polypeptide (glucagon,VIP family),including 2 isoforms PACAP27 and
PACAP38,expressed in the retinohypothalamus tract (RHT),acting as a pivotal modulator of glutamatergic regulation
of the suprachiasmatic circadian clock

     Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005057receptor signaling protein activity IEA--
GO:0005102receptor binding IPI7680413
GO:0005179hormone activity ----
GO:0005184neuropeptide hormone activity IDA--
GO:0016521pituitary adenylate cyclase activating polypeptide activity IDA9603988
     
Find genes that share ontologies with ADCYAP1           About GenesLikeMe


Phenotypes:
     1 GenomeRNAi human phenotype for ADCYAP1:
 Increased cilium length after  

     12 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adcyap1):
 adipose tissue  behavior/neurological  cellular  growth/size/body  hematopoietic system 
 homeostasis/metabolism  immune system  liver/biliary system  mortality/aging  muscle 
 nervous system  reproductive system 

Find genes that share phenotypes with ADCYAP1           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for ADCYAP1: Adcyap1tm1Clw Adcyap1tm1Eid Adcyap1tm1Nms Adcyap1tm1Aba

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADCYAP1
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Selected qRT-PCR Assays for microRNAs that regulate ADCYAP1 (see all 52):
hsa-miR-579 hsa-miR-520f hsa-miR-485-3p hsa-miR-219-5p hsa-miR-508-3p hsa-miR-374a* hsa-miR-124 hsa-miR-3150b-3p
SwitchGear 3'UTR luciferase reporter plasmidADCYAP1 3' UTR sequence
Inhib. RNA
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Predesigned siRNA for gene silencing in human, mouse, rat ADCYAP1

Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCYAP1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
PACA_HUMAN, P18509: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2
plasma membrane2
cytoskeleton1
cytosol1
endoplasmic reticulum1
mitochondrion1
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0043195terminal bouton IEA--

Find genes that share ontologies with ADCYAP1           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ADCYAP1 About   (see all 9)  
See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
2Signaling by FGFR
NGF signalling via TRKA from the plasma membrane0.71
Signalling by NGF0.71
3ADP signalling through P2Y purinoceptor 12
Glucagon-type ligand receptors0.61
Class B/2 (Secretin family receptors)0.36
4Activation of TRKA receptors
Activation of TRKA receptors
NGF-independant TRKA activation0.00
5Peptide ligand-binding receptors
GPCR ligand binding0.71


Find genes that share SuperPaths with ADCYAP1           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ADCYAP1
    PACAP Signaling

1 BioSystems Pathway for ADCYAP1
    SIDS Susceptibility Pathways

3 Reactome Pathways for ADCYAP1
    Glucagon-type ligand receptors
G alpha (s) signalling events
NGF-independant TRKA activation


1 Kegg Pathway  (Kegg details for ADCYAP1):
    Insulin secretion

    Pathway & Disease-focused RT2 Profiler PCR Array including ADCYAP1: 
          Obesity in human mouse rat

Interactions:

    GeneGlobe Interaction Network for ADCYAP1

Selected Interacting proteins for ADCYAP1 (P185092, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
DPP4P274872, 3MINT-8090860 I2D: score=1 
FAPQ128842, 3MINT-8094219 I2D: score=1 
CASP2P425753I2D: score=2 
MMEP084733I2D: score=2 
SCTRP478723I2D: score=2 
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Gene Ontology (GO): Selected biological process terms (see all 42):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001541ovarian follicle development IEA--
GO:0001662behavioral fear response IEA--
GO:0001821histamine secretion IEA--
GO:0002865negative regulation of acute inflammatory response to antigenic stimulus IEA--
GO:0002878negative regulation of acute inflammatory response to non-antigenic stimulus IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for ADCYAP1 available from Tocris Bioscience    About this table
CompoundAction CAS #
PACAP 6-38Potent PAC1 receptor antagonist[143748-18-9]
PACAP 1-38Potent stimulator of adenylyl cyclase[137061-48-4]

1 DrugBank Compound for ADCYAP1    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
2,6-Diamino-Hexanoic Acid Amide-- --target----

Selected Novoseek inferred chemical compound relationships for ADCYAP1 gene (see all 112)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pacap 38 96.5 248 12147212 (9), 8752106 (8), 9829998 (7), 15870074 (6) (see all 57)
adenylate 96.4 1584 17940421 (7), 7479307 (6), 1655384 (4), 1324148 (3) (see all 99)
pacaps 91.3 12 8404665 (1), 12716746 (1), 15056941 (1), 8698838 (1) (see all 9)
helospectin 81.2 18 7761627 (5), 8897643 (2), 8564257 (2), 7914821 (1) (see all 6)
forskolin 74.2 60 10595920 (2), 15882914 (2), 10646500 (2), 16455786 (2) (see all 40)
cyclic amp 72.7 120 15800375 (5), 8857610 (4), 8752106 (4), 9681437 (4) (see all 37)
helospectin i 72.5 8 8680719 (3), 7914821 (3)
maxadilan 72.4 12 10657479 (6), 15518905 (3), 15034198 (1), 16888153 (1)
apamin 48.2 7 8071835 (2), 8680719 (1), 8751083 (1), 11207070 (1)
2',5'-dideoxyadenosine 48.2 2 10414962 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ADCYAP1 gene (2 alternative transcripts): 
NM_001099733.1  NM_001117.4  

Unigene Cluster for ADCYAP1:

Adenylate cyclase activating polypeptide 1 (pituitary)
Hs.531719  [show with all ESTs]
Unigene Representative Sequence: AK095723
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000450565 ENST00000579794(uc010dkg.3 uc010dkh.3) ENST00000269200
ENST00000581602
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hsa-miR-579 hsa-miR-520f hsa-miR-485-3p hsa-miR-219-5p hsa-miR-508-3p hsa-miR-374a* hsa-miR-124 hsa-miR-3150b-3p
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Additional mRNA sequence: 

AK095723.1 AK294233.1 AK313050.1 BC093837.1 BC101803.1 S83513.1 

7 DOTS entries:

DT.110319  DT.405957  DT.95288570  DT.100759469  DT.100022840  DT.91988881  DT.100746685 

Selected AceView cDNA sequences (see all 61):

CR603595 AI697629 AI932543 BE220888 AV703144 CD244263 T11038 BI793247 
BU783065 CK820262 BU579487 BX391878 BM142346 BX333515 BQ549183 BM354129 
CA771743 BM142521 AA772782 AA379639 NM_001117 BU074212 AA991809 AA081575 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ADCYAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
ADCYAP1 Expression
About this image


ADCYAP1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Neural Tube (Nervous System)    fully expand to see all 4 entries
         Metencephalon
 
 Brain (Nervous System)    fully expand to see all 3 entries
         Adult Dopaminergic Neurons Ventral Tegmental Area
         Cerebellum
         Midbrain dopaminergic-like neurons
 
 Neurons
         Adult Dopaminergic Neurons Ventral Tegmental Area
         Midbrain dopaminergic-like neurons
 
 Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
         Foregut
 
 Eye (Sensory Organs)
         Retina
ADCYAP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ADCYAP1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.531719
    Pathway & Disease-focused RT2 Profiler PCR Array including ADCYAP1: 
          Obesity in human mouse rat

Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCYAP1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for ADCYAP1 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Adcyap11 , 5 adenylate cyclase activating polypeptide 11, 5 85.52(n)1
82.86(a)1
  17 (60.67 cM)5
115161  NM_009625.21  NP_033755.11 
 931994225 
chicken
(Gallus gallus)
Aves ADCYAP11 adenylate cyclase activating polypeptide 1 (pituitary) less 76.61(n)
69.59(a)
  408251  NM_001001291.2  NP_001001291.2 
lizard
(Anolis carolinensis)
Reptilia ADCYAP16
adenylate cyclase activating polypeptide 1 (pituit...
67(a)
1 ↔ 1
4(39652763-39674253)
African clawed frog
(Xenopus laevis)
Amphibia PACAP2 pituitary adenylate cyclase-activating peptide 76.59(n)    AF187877.1 
zebrafish
(Danio rerio)
Actinopterygii Dr.107392 Danio rerio adenylate cyclase-activating peptide mRNA, complete cds less 81.19(n)    AF329730.1 


ENSEMBL Gene Tree for ADCYAP1 (if available)
TreeFam Gene Tree for ADCYAP1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ADCYAP1 gene
VIP2  
1 SIMAP similar gene for ADCYAP1 using alignment to 3 protein entries:     PACA_HUMAN (see all proteins):
VIP

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ADCYAP1 (see all 253)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 18 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs28465821,2
C,H--902954(+) TATCTG/TGGAAA 1 -- us2k10--------
rs28465831,2
C,F,A,H--902965(+) AAGCAA/TGCAGA 1 -- us2k116Minor allele frequency- T:0.23NS EA WA NA CSA 772
rs1928558631,2
--902992(+) TAAATA/GTGAGA 1 -- us2k10--------
rs1827292951,2
--903109(+) ATTTTA/CTTTCT 1 -- us2k10--------
rs113404261,2
C,F--903131(+) TCTTCT/-TTTTT 1 -- us2k1 trp33Minor allele frequency- -:0.50NA CSA 6
rs2008859081,2
--903132(+) TTCTT-/CTTTTT 1 -- us2k10--------
rs25159111,2
H--903154(+) AAATAG/AACCTG 1 -- us2k14Minor allele frequency- A:0.00NS EA 400
rs1873748991,2
--903219(+) GGAAGC/GCTCTG 2 -- us2k10--------
rs28569641,2
H--903315(+) TGTTAG/AAAACC 2 -- us2k14Minor allele frequency- A:0.00NS EA 410
rs1921573781,2
--903325(+) CTTCAC/TCAGGT 2 -- us2k10--------

HapMap Linkage Disequilibrium report for ADCYAP1 (904944 - 912173 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for ADCYAP1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv517252CNV Loss19592680
nsv518677CNV Loss19592680
nsv528169CNV Loss19592680
nsv909288CNV Loss21882294

Human Gene Mutation Database (HGMD): ADCYAP1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ADCYAP1
DNA2.0 Custom Variant and Variant Library Synthesis for ADCYAP1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 102980    OMIM disorders: --

7 diseases for ADCYAP1:    
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post-traumatic stress disorder    carpal tunnel syndrome    chronic fatigue syndrome    pulmonary disease, chronic obstructive
sudden infant death syndrome    hirschsprung's disease    schizophrenia

2 diseases from the University of Copenhagen DISEASES database for ADCYAP1:
Sudden infant death syndrome     Vascular disease

Find genes that share disorders with ADCYAP1           About GenesLikeMe

Selected Novoseek inferred disease relationships for ADCYAP1 gene (see all 71)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
gulf war syndrome 56.3 1 15922114 (1)
pituitary adenoma 37.1 24 9846969 (5), 10595920 (3), 9285938 (3), 7527412 (2) (see all 6)
pituitary adenoma nonfunctioning 33.9 1 8547947 (1)
pheochromocytoma 33.9 8 2175177 (2), 7759058 (1), 12438166 (1), 10567198 (1) (see all 6)
sudden infant death syndrome 33 5 19120039 (2), 18589006 (1), 15922114 (1)
cholera 26.5 5 1337557 (1), 15109935 (1), 1309195 (1), 11476937 (1)
chronic fatigue syndrome 25.9 1 15922114 (1)
prolactinoma 24.8 3 7479307 (1), 9846969 (1)
shock septic 24.2 10 12794054 (2), 18650785 (2), 11792830 (1), 18098289 (1) (see all 6)
pituitary tumors 22.6 4 7479307 (1), 19236332 (1)

Genetic Association Database (GAD): ADCYAP1
Human Genome Epidemiology (HuGE) Navigator: ADCYAP1 (15 documents)

Export disorders for ADCYAP1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ADCYAP1 gene, integrated from 10 sources (see all 623):
(articles sorted by number of sources associating them with ADCYAP1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (PubMed id 1730060)1, 2, 3, 9 Hosoya M.... Fujino M. (Biochim. Biophys. Acta 1992)
  2. Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes. (PubMed id 11968092)1, 2, 4 Gu H.F. (Hum. Mutat. 2002)
  3. Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide. (PubMed id 1739432)1, 2, 9 Ohkubo S.... Fujino M. (DNA Cell Biol. 1992)
  4. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. (PubMed id 19914336)1, 4, 9 Hashimoto R....Kunugi H. (Neurosci. Lett. 2010)
  5. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. (PubMed id 2302217)1, 2, 9 Kimura C.... Fujino M. (Biochem. Biophys. Res. Commun. 1990)
  6. Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia. (PubMed id 20414143)1, 4, 9 Koga M....Arinami T. (Psychiatr. Genet. 2010)
  7. Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution. (PubMed id 1483839)1, 2, 9 Inooka H.... Fujino M. (Int. J. Pept. Protein Res. 1992)
  8. Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP). (PubMed id 19120039)1, 4, 9 Cummings K.J....Wilson R.J. (Acta Paediatr. 2009)
  9. Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder. (PubMed id 18349695)1, 4, 9 Lohoff F.W....Berrettini W.H. (Psychiatr. Genet. 2008)
  10. The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PubMed id 17175032)1, 4, 9 Cunningham S....Vandenbroeck K. (J. Neuroimmunol. 2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 116 HGNC: 241 AceView: ADCYAP1 Ensembl:ENSG00000141433 euGenes: HUgn116
ECgene: ADCYAP1 Kegg: 116 H-InvDB: ADCYAP1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ADCYAP1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ADCYAP1 gene:
Search GeneIP for patents involving ADCYAP1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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