Aliases for ADCYAP1 Gene
Aliases for ADCYAP1 Gene
External Ids for ADCYAP1 Gene
- HGNC: 241
- Entrez Gene: 116
- Ensembl: ENSG00000141433
- OMIM: 102980
- UniProtKB: P18509
Previous GeneCards Identifiers for ADCYAP1 Gene
- GC18M001066
- GC18P000892
Summaries for ADCYAP1 Gene
-
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
GeneCards Summary for ADCYAP1 Gene
ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1) is a Protein Coding gene. Diseases associated with ADCYAP1 include Persian Gulf Syndrome and Holoprosencephaly-3. Among its related pathways are Presynaptic function of Kainate receptors and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. GO annotations related to this gene include receptor binding and signal transducer activity, downstream of receptor. An important paralog of this gene is VIP.
UniProtKB/Swiss-Prot for ADCYAP1 Gene
-
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
-
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCYAP1 Gene
Genomics for ADCYAP1 Gene
Regulatory Elements for ADCYAP1 Gene
Enhancers for ADCYAP1 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH18G001002 | 0.9 | ENCODE | 8.8 | +98.6 | 98557 | 1.2 | HDAC1 PKNOX1 ATF1 TBL1XR1 ZNF766 GATA2 FOS ETV6 ZBTB11 JUNB | ADCYAP1 GC18M001017 ENSG00000272461 |
| GH18G000961 | 1 | Ensembl ENCODE | 7.7 | +57.5 | 57536 | 0.6 | HDAC1 CTCF ATF1 ESRRA HINFP ARNT RAD21 FOSL1 ZNF766 ZBTB48 | ADCYAP1 LOC105371953 LINC01904 |
| GH18G000984 | 0.5 | ENCODE | 8.9 | +81.3 | 81290 | 1.4 | POLR2A SMARCA4 KDM5B CHD7 | ADCYAP1 ENSG00000265179 ENSG00000272461 GC18M001017 |
| GH18G001014 | 0.6 | ENCODE | 6.1 | +110.4 | 110415 | 0.8 | HDAC2 POLR2A SMARCA4 PBX2 ZMYM3 KDM1A | ADCYAP1 GC18M001017 ENSG00000272461 |
| GH18G001015 | 0.5 | ENCODE | 6.6 | +111.4 | 111352 | 0.8 | CTCF HDAC2 TEAD4 KDM1A | ADCYAP1 GC18M001017 ENSG00000272461 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ADCYAP1 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ADCYAP1 gene promoter:
Regulatory Element Products
Genomic Location for ADCYAP1 Gene
- Chromosome:
- 18
- Start:
- 904,345 bp from pter
- End:
- 912,172 bp from pter
- Size:
- 7,828 bases
- Orientation:
- Plus strand
Genomic View for ADCYAP1 Gene
Genes around ADCYAP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18p11.32 by Ensembl
- 18p11.32 by Entrez Gene
- 18p11.32 by HGNC
ADCYAP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADCYAP1 Gene
Proteins for ADCYAP1 Gene
-
Protein details for ADCYAP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P18509-PACA_HUMAN
- Recommended name:
- Pituitary adenylate cyclase-activating polypeptide
- Protein Accession:
- P18509
- B2R7N4
- Q52LQ0
Protein attributes for ADCYAP1 Gene
- Size:
- 176 amino acids
- Molecular mass:
- 18835 Da
- Quaternary structure:
-
- Interacts with ADCYAP1R1 (via N-terminal extracellular domain).
Protein Expression for ADCYAP1 Gene
Post-translational modifications for ADCYAP1 Gene
Other Protein References for ADCYAP1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
Abcam antibodies for ADCYAP1
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Cloud-Clone Corp. Antibodies for ADCYAP1
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- antibodies-online Antibodies for ADCYAP1: See all 107
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-
Santa Cruz Biotechnology (SCBT) Antibodies for ADCYAP1
Protein Products
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-
Cloud-Clone Corp. Proteins for ADCYAP1
- antibodies-online Proteins for ADCYAP1: See all 15
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-
Abcam proteins for ADCYAP1
Assay Products
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Cloud-Clone Corp Assay Kits for ADCYAP1
- antibodies-online Kits for ADCYAP1: See all 64
No data available for DME Specific Peptides for ADCYAP1 Gene
Domains & Families for ADCYAP1 Gene
Gene Families for ADCYAP1 Gene
- HGNC:
Protein Domains for ADCYAP1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADCYAP1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P18509- Family:
-
- Belongs to the glucagon family.
Function for ADCYAP1 Gene
Molecular function for ADCYAP1 Gene
- GENATLAS Biochemistry:
- pituitary adenylyl cyclase activating polypeptide (glucagon,VIP family),including 2 isoforms PACAP27 and PACAP38,expressed in the retinohypothalamus tract (RHT),acting as a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock
- UniProtKB/Swiss-Prot Function:
- Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005057 | signal transducer activity, downstream of receptor | IEA | -- |
| GO:0005102 | receptor binding | IPI | 7680413 |
| GO:0005179 | hormone activity | IEA | -- |
| GO:0005184 | neuropeptide hormone activity | IDA | 23800469 |
| GO:0005515 | protein binding | IPI | 25451228 |
Phenotypes for ADCYAP1 Gene
- MGI mutant phenotypes for ADCYAP1:
-
inferred from 5 alleles
- mortality/aging
- cellular phenotype
- behavior/neurological phenotype
- growth/size/body region phenotype
- immune system phenotype
- muscle phenotype
- nervous system phenotype
- homeostasis/metabolism phenotype
- reproductive system phenotype
- hematopoietic system phenotype
- liver/biliary system phenotype
- adipose tissue phenotype
- no phenotypic analysis
- GenomeRNAi human phenotypes for ADCYAP1:
Animal Models for ADCYAP1 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADCYAP1 gene
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CRISPR Products
-
OriGene CRISPR knockouts for ADCYAP1
-
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miRNA for ADCYAP1 Gene
- miRTarBase miRNAs that target ADCYAP1
-
- hsa-mir-1277-5p (MIRT508276)
- hsa-mir-190a-3p (MIRT508277)
- hsa-mir-6083 (MIRT508278)
- hsa-mir-6074 (MIRT508279)
- hsa-mir-5011-5p (MIRT508280)
- hsa-mir-1284 (MIRT549625)
- hsa-mir-335-3p (MIRT639081)
- hsa-mir-1305 (MIRT639082)
- hsa-mir-607 (MIRT639083)
- hsa-mir-452-3p (MIRT639084)
- hsa-mir-4778-3p (MIRT639085)
- hsa-mir-548o-3p (MIRT639086)
- hsa-mir-1323 (MIRT639087)
- hsa-mir-4803 (MIRT639088)
- hsa-mir-450b-5p (MIRT712586)
- hsa-mir-106a-3p (MIRT712587)
- hsa-mir-7641 (MIRT712588)
- hsa-mir-885-3p (MIRT712589)
- hsa-mir-4695-3p (MIRT712590)
- hsa-mir-6868-5p (MIRT712591)
- hsa-mir-1976 (MIRT712592)
- hsa-mir-3653-5p (MIRT712593)
- hsa-mir-8073 (MIRT712594)
- hsa-mir-221-5p (MIRT712595)
- hsa-mir-8066 (MIRT712596)
miRNA Products
- Search ViGene Biosciences for ADCYAP1
Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ADCYAP1
-
ViGene Biosciences adenoviral particle packaged cDNA for ADCYAP1 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADCYAP1 gene
- Search ViGene Biosciences for ADCYAP1
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCYAP1 Gene
Localization for ADCYAP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADCYAP1 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| plasma membrane | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| cytosol | 2 |
| cytoskeleton | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | TAS | -- |
| GO:0005615 | extracellular space | IEA | -- |
| GO:0005622 | intracellular | IEA | -- |
| GO:0043195 | terminal bouton | IEA | -- |
Pathways & Interactions for ADCYAP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Signaling by GPCR | ||
| 2 | Activation of TRKA receptors | ||
| 3 | Presynaptic function of Kainate receptors | ||
| 4 | RET signaling | ||
| 5 | Insulin secretion | ||
Pathways by source for ADCYAP1 Gene
1 BioSystems pathway for ADCYAP1 Gene
11 Reactome pathways for ADCYAP1 Gene
2 KEGG pathways for ADCYAP1 Gene
Interacting Proteins for ADCYAP1 Gene
Selected Interacting proteins:
ENSP00000411658
P18509-PACA_HUMAN
for ADCYAP1 Gene via
STRING
IID
MINT
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001541 | ovarian follicle development | IEA | -- |
| GO:0001662 | behavioral fear response | IEA | -- |
| GO:0001821 | histamine secretion | IEA | -- |
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0002865 | negative regulation of acute inflammatory response to antigenic stimulus | IEA | -- |
Drugs & Compounds for ADCYAP1 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) Tocris Compounds for ADCYAP1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| PACAP 6-38 | Potent PAC1 receptor antagonist | 143748-18-9 |
Transcripts for ADCYAP1 Gene
mRNA/cDNA for ADCYAP1 Gene
- (3) REFSEQ mRNAs :
- (61) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ADCYAP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCYAP1
- GenScript: Design CRISPR guide RNA sequences for ADCYAP1
miRNA Products
- Search ViGene Biosciences for ADCYAP1
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for ADCYAP1
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Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADCYAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCYAP1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for ADCYAP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Neural Tube (Nervous System)
-
Brain (Nervous System)
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Cerebellum
- Midbrain dopaminergic-like neurons(Kriks S et. al. 2011)
-
Neurons
- Adult Dopaminergic Neurons Ventral Tegmental Area
- Midbrain dopaminergic-like neurons(Kriks S et. al. 2011)
- Gut Tube (Gastrointestinal Tract)
- Eye (Sensory Organs)
-
Spinal Cord (Nervous System)
-
Pancreas (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for ADCYAP1 Gene
This gene is overexpressed in Brain - Hypothalamus (x10.9), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Frontal Cortex (BA9) (x4.3).
This gene is overexpressed in Heart (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCYAP1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADCYAP1 Gene:
ADCYAP1SOURCE GeneReport for Unigene cluster for ADCYAP1 Gene:
Hs.531719Evidence on tissue expression from TISSUES for ADCYAP1 Gene
- Nervous system(4.7)
- Pancreas(3.2)
- Adrenal gland(2.3)
- Intestine(2.1)
Primer Products
-
OriGene qPCR primer pairs for ADCYAP1
-
OriGene qPCR primer pairs and template standards for ADCYAP1
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCYAP1 Gene
Orthologs for ADCYAP1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADCYAP1 34 |
|
||
| PACAP 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | ADCYAP1 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Adcyap1 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adcyap1 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ADCYAP1 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADCYAP1 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADCYAP1 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADCYAP1 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADCYAP1 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adcyap1 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | PACAP 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | adcyap1b 35 |
|
OneToMany | |
| adcyap1a 35 |
|
OneToMany | |||
| Dr.10739 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.8047 34 |
|
- Species where no ortholog for ADCYAP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for ADCYAP1 Gene
(1) SIMAP similar genes for ADCYAP1 Gene using alignment to 3 proteins:
Variants for ADCYAP1 Gene
| SNP ID | Clin | Chr 18 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000146897 | -- | 910,513(+) | AACAA(A/G)GTGAA | utr-variant-3-prime | |
| rs1000270789 | -- | 903,347(+) | GGAAC(C/T)CTCAT | upstream-variant-2KB | |
| rs1000401843 | -- | 912,235(+) | AAAGT(A/T)TTATA | downstream-variant-500B | |
| rs1000621347 | -- | 903,631(+) | TGGAC(G/T)CTACA | upstream-variant-2KB | |
| rs1000752992 | -- | 912,429(+) | ACATT(A/G)TAAGA | downstream-variant-500B |
Residual Variation Intolerance Score:
51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.94;
74.52% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ADCYAP1 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCYAP1 Gene
Disorders for ADCYAP1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| persian gulf syndrome |
|
|
| holoprosencephaly-3 |
|
|
| sudden infant death syndrome |
|
|
| post-traumatic stress disorder |
|
|
| pheochromocytoma |
|
Search ADCYAP1 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ADCYAP1
No data available for UniProtKB/Swiss-Prot and Genatlas for ADCYAP1 Gene
Publications for ADCYAP1 Gene
- Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (PMID: 1730060) Hosoya M. … Fujino M. (Biochim. Biophys. Acta 1992) 2 3 4 22 64
- Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. (PMID: 19914336) Hashimoto R. … Kunugi H. (Neurosci. Lett. 2010) 3 22 46 64
- Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP). (PMID: 19120039) Cummings K.J. … Wilson R.J. (Acta Paediatr. 2009) 3 22 46 64
- Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder. (PMID: 18349695) Lohoff F.W. … Berrettini W.H. (Psychiatr. Genet. 2008) 3 22 46 64
- Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes. (PMID: 11968092) Gu H.F. (Hum. Mutat. 2002) 3 4 46 64
Products for ADCYAP1 Gene
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- Search antibodies-online for peptides
- GeneTex ADCYAP1 antibody for ADCYAP1
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- ViGene Biosciences adenoviral particle packaged cDNA for ADCYAP1 gene
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- Horizon Cell Lines for ADCYAP1
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- VectorBuilder custom plasmid, inducible vectors for ADCYAP1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCYAP1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ADCYAP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
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