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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCYAP1 Gene

protein-coding   GIFtS: 64
GCID: GC18P000895

Adenylate Cyclase Activating Polypeptide 1 (Pituitary)

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenylate Cyclase Activating Polypeptide 1 (Pituitary)1 2
prepro-PACAP1 2
PACAP2 3
Pituitary Adenylate Cyclase-Activating Polypeptide2

External Ids:    HGNC: 2411   Entrez Gene: 1162   Ensembl: ENSG000001414337   OMIM: 1029805   UniProtKB: P185093   

Export aliases for ADCYAP1 gene to outside databases

Previous GC identifers: GC18M001066 GC18P000892


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCYAP1 Gene:
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides
stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the
transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress
responses. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2013)

GeneCards Summary for ADCYAP1 Gene: 
ADCYAP1 (adenylate cyclase activating polypeptide 1 (pituitary)) is a protein-coding gene. Diseases associated with ADCYAP1 include post-traumatic stress disorder, and carpal tunnel syndrome, and among its related super-pathways are Signaling by GPCR and Glucagon-type ligand receptors. GO annotations related to this gene include neuropeptide hormone activity and receptor binding. An important paralog of this gene is VIP.

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509
Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells

summary for ADCYAP1 Gene:
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors
referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1
receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb,
thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the
adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock,
emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human
PAC1 receptor gene has been localized to chromosome 7p14.

Gene Wiki entry for ADCYAP1 (Pituitary adenylate cyclase-activating peptide) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000018.9  NT_010859.14  NC_018929.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCYAP1 gene promoter:
         CREB   GR   AP-1   deltaCREB   ATF-2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCYAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCYAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCYAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11

ADCYAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCYAP1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P000895:  view genomic region     (about GC identifiers)

Start:
904,944 bp from pter      End:
912,173 bp from pter
Size:
7,230 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509 (See protein sequence)
Recommended Name: Pituitary adenylate cyclase-activating polypeptide precursor  
Size: 176 amino acids; 18835 Da
Subunit: Interacts with ADCYAP1R1 (via N-terminal extracellular domain)
Subcellular location: Secreted
3 PDB 3D structures from and Proteopedia for ADCYAP1:
1GEA (3D)        2D2P (3D)        2JOD (3D)    
Secondary accessions: B2R7N4 Q52LQ0

Explore the universe of human proteins at neXtProt for ADCYAP1: NX_P18509

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18509

  • ADCYAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001093203.1  NP_001108.2  

    ENSEMBL proteins: 
     ENSP00000411658   ENSP00000462647  
    Reactome Protein details: P18509
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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IEA--
    GO:0043195terminal bouton IEA--

    ADCYAP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR000532 Glucagon_GIP_secretin_VIP

    Graphical View of Domain Structure for InterPro Entry P18509

    ProtoNet protein and cluster: P18509

    1 Blocks protein domain: IPB000532 Glucagon/GIP/secretin/VIP

    UniProtKB/Swiss-Prot: PACA_HUMAN, P18509
    Similarity: Belongs to the glucagon family


    ADCYAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PACA_HUMAN, P18509
    Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells

         Genatlas biochemistry entry for ADCYAP1:
    pituitary adenylyl cyclase activating polypeptide (glucagon,VIP family),including 2 isoforms PACAP27 and
    PACAP38,expressed in the retinohypothalamus tract (RHT),acting as a pivotal modulator of glutamatergic regulation
    of the suprachiasmatic circadian clock

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057receptor signaling protein activity IEA--
    GO:0005102receptor binding IPI7680413
    GO:0005179hormone activity ----
    GO:0005184neuropeptide hormone activity IDA--
    GO:0016521pituitary adenylate cyclase activating polypeptide activity IDA9603988
         
    ADCYAP1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADCYAP1:
     Increased cilium length after  

         13 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adcyap1):
     adipose tissue  behavior/neurological  cellular  embryogenesis  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  liver/biliary system  mortality/aging 
     muscle  nervous system  reproductive system 

    ADCYAP1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADCYAP1: Adcyap1tm1Clw Adcyap1tm1Eid Adcyap1tm1Aba Adcyap1tm1Nms

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADCYAP1 About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2Prostacyclin signalling through prostacyclin receptor
    Glucagon-type ligand receptors0.58
    G alpha (s) signalling events0.31
    Class B/2 (Secretin family receptors)0.36
    3NGF-independant TRKA activation
    NGF-independant TRKA activation0.83
    Activation of TRKA receptors0.83
    4Signaling by FGFR
    NGF signalling via TRKA from the plasma membrane0.71
    Signalling by NGF0.71
    5Class A/1 (Rhodopsin-like receptors)
    GPCR ligand binding0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ADCYAP1
        Adenylate cyclase-activating neuropeptides


    1 BioSystems Pathway for ADCYAP1
        SIDS Susceptibility Pathways

    5/11        Reactome Pathways for ADCYAP1 (see all 11)
        GPCR downstream signaling
    Glucagon-type ligand receptors
    Signaling by GPCR
    GPCR ligand binding
    NGF signalling via TRKA from the plasma membrane


    1         Kegg Pathway  (Kegg details for ADCYAP1):
        Insulin secretion


    ADCYAP1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADCYAP1

    5/10 Interacting proteins for ADCYAP1 (P185092, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DPP4P274872, 3MINT-8090860 I2D: score=1 
    FAPQ128842, 3MINT-8094219 I2D: score=1 
    CASP2P425753I2D: score=2 
    MMEP084733I2D: score=2 
    SCTRP478723I2D: score=2 
    About this table

    Gene Ontology (GO): 5/41 biological process terms (GO ID links to tree view) (see all 41):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001541ovarian follicle development IEA--
    GO:0001662behavioral fear response IEA--
    GO:0001821histamine secretion IEA--
    GO:0002865negative regulation of acute inflammatory response to antigenic stimulus IEA--
    GO:0002878negative regulation of acute inflammatory response to non-antigenic stimulus IEA--

    ADCYAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADCYAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADCYAP1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    PACAP 6-38Potent PAC1 receptor antagonist[143748-18-9]
    PACAP 1-38Potent stimulator of adenylyl cyclase[137061-48-4]

    1 DrugBank Compound for ADCYAP1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,6-Diamino-Hexanoic Acid Amide-- --target----

    10/112 Novoseek inferred chemical compound relationships for ADCYAP1 gene (see all 112)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pacap 38 96.5 248 12147212 (9), 8752106 (8), 9829998 (7), 15870074 (6) (see all 57)
    adenylate 96.4 1584 17940421 (7), 7479307 (6), 1655384 (4), 1324148 (3) (see all 99)
    pacaps 91.3 12 8404665 (1), 12716746 (1), 15056941 (1), 8698838 (1) (see all 9)
    helospectin 81.2 18 7761627 (5), 8897643 (2), 8564257 (2), 7914821 (1) (see all 6)
    forskolin 74.2 60 10595920 (2), 15882914 (2), 10646500 (2), 16455786 (2) (see all 40)
    cyclic amp 72.7 120 15800375 (5), 8857610 (4), 8752106 (4), 9681437 (4) (see all 37)
    helospectin i 72.5 8 8680719 (3), 7914821 (3)
    maxadilan 72.4 12 10657479 (6), 15518905 (3), 15034198 (1), 16888153 (1)
    apamin 48.2 7 8071835 (2), 8680719 (1), 8751083 (1), 11207070 (1)
    2',5'-dideoxyadenosine 48.2 2 10414962 (1)

    Search CenterWatch for drugs/clinical trials and news about ADCYAP1 / PACA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ADCYAP1 gene (2 alternative transcripts): 
    NM_001099733.1  NM_001117.4  

    Unigene Clusters for ADCYAP1:

    Adenylate cyclase activating polypeptide 1 (pituitary)
    Hs.531719  [show with all ESTs], Hs.727476
    Unigene Representative Sequences: AK095723, AB537500
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450565 ENST00000579794(uc010dkg.3 uc010dkh.3) ENST00000269200
    ENST00000581602

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    Additional mRNA sequence: AB537500.1 

    7 DOTS entries:

    DT.110319  DT.405957  DT.95288570  DT.100759469  DT.100022840  DT.91988881  DT.100746685 

    24/61 AceView cDNA sequences (see all 61):

    CR603595 AV703144 CD244263 T11038 AI932543 BE220888 AI697629 BI793247 
    BX333515 CA772587 BM354004 AA772803 BX391878 CA771743 BI793075 AI813950 
    S83513 BF448881 BU071058 BM142346 NM_001117 AA991809 AA772782 BU783065 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCYAP1 expression in normal human tissues (normalized intensities)      ADCYAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADCYAP1 Expression
    About this image


    ADCYAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Midbrain dopaminergic-like neurons ( Generation of midbrain dopaminergic, forebrain...
             Olfactory Bulb   
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Midgut
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    Genevestigator expression for ADCYAP1

    SOURCE GeneReport for Unigene clusters: Hs.531719 Hs.727476
        SABiosciences Expression via Pathway-Focused PCR Array including ADCYAP1: 
              Obesity in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ADCYAP1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcyap11 , 5 adenylate cyclase activating polypeptide 11, 5 85.52(n)1
    82.86(a)1
      17 (60.67 cM)5
    115161  NM_009625.21  NP_033755.11 
     931994225 
    chicken
    (Gallus gallus)
    Aves ADCYAP11 adenylate cyclase activating polypeptide 1 (pituitary) 77.19(n)
    70.18(a)
      408251  NM_001001291.2  NP_001001291.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADCYAP16
    Uncharacterized protein
    67(a)
    1 ↔ 1
    4(39652763-39674253)
    African clawed frog
    (Xenopus laevis)
    Amphibia PACAP2 pituitary adenylate cyclase-activating peptide 76.59(n)    AF187877.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.107392 Danio rerio adenylate cyclase-activating peptide mRNA, more 81.19(n)    AF329730.1 


    ENSEMBL Gene Tree for ADCYAP1 (if available)
    TreeFam Gene Tree for ADCYAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCYAP1 gene
    VIP2  
    1 SIMAP similar gene for ADCYAP1 using alignment to 3 protein entries:     PACA_HUMAN (see all proteins):
    VIP

    ADCYAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/253 SNPs in ADCYAP1 are shown (see all 253)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs28465821,2
    C,H--902954(+) TATCTG/TGGAAA 1 -- us2k10--------
    rs28465831,2
    C,F,A,H--902965(+) AAGCAA/TGCAGA 1 -- us2k116Minor allele frequency- T:0.23NS EA WA NA CSA 772
    rs1928558631,2
    --902992(+) TAAATA/GTGAGA 1 -- us2k10--------
    rs1827292951,2
    --903109(+) ATTTTA/CTTTCT 1 -- us2k10--------
    rs113404261,2
    C,F--903131(+) TCTTCT/-TTTTT 1 -- us2k1 trp33Minor allele frequency- -:0.50NA CSA 6
    rs2008859081,2
    --903132(+) TTCTT-/CTTTTT 1 -- us2k10--------
    rs25159111,2
    H--903154(+) AAATAG/AACCTG 1 -- us2k14Minor allele frequency- A:0.00NS EA 400
    rs1873748991,2
    --903219(+) GGAAGC/GCTCTG 2 -- us2k10--------
    rs28569641,2
    H--903315(+) TGTTAG/AAAACC 2 -- us2k14Minor allele frequency- A:0.00NS EA 410
    rs1921573781,2
    --903325(+) CTTCAC/TCAGGT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCYAP1 (904944 - 912173 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADCYAP1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv517252CNV Loss19592680
    nsv518677CNV Loss19592680
    nsv528169CNV Loss19592680
    nsv909288CNV Loss21882294


    Human Gene Mutation Database (HGMD): ADCYAP1
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ADCYAP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 102980    OMIM disorders: --

    20/75 diseases for ADCYAP1 (see all 75):    About MalaCards
    post-traumatic stress disorder    carpal tunnel syndrome    adenohypophysitis    chronic fatigue syndrome
    sudden infant death syndrome    anoxia    paraganglioma    sleep disorder
    gastroduodenitis    menkes disease    neuroendocrine tumor    pituitary adenoma
    hirschsprung's disease    ependymoma    prolactinoma    brain ischemia
    bipolar disorder    pituitary tumors    oligodendroglioma    pheochromocytoma

    2 diseases from the University of Copenhagen DISEASES database for ADCYAP1:
    Sudden infant death syndrome     Vascular disease

    ADCYAP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/71 Novoseek inferred disease relationships for ADCYAP1 gene (see all 71)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gulf war syndrome 56.3 1 15922114 (1)
    pituitary adenoma 37.1 24 9846969 (5), 10595920 (3), 9285938 (3), 7527412 (2) (see all 6)
    pituitary adenoma nonfunctioning 33.9 1 8547947 (1)
    pheochromocytoma 33.9 8 2175177 (2), 7759058 (1), 12438166 (1), 10567198 (1) (see all 6)
    sudden infant death syndrome 33 5 19120039 (2), 18589006 (1), 15922114 (1)
    cholera 26.5 5 1337557 (1), 15109935 (1), 1309195 (1), 11476937 (1)
    chronic fatigue syndrome 25.9 1 15922114 (1)
    prolactinoma 24.8 3 7479307 (1), 9846969 (1)
    shock septic 24.2 10 12794054 (2), 18650785 (2), 11792830 (1), 18098289 (1) (see all 6)
    pituitary tumors 22.6 4 7479307 (1), 19236332 (1)

    Genetic Association Database (GAD): ADCYAP1
    Human Genome Epidemiology (HuGE) Navigator: ADCYAP1 (15 documents)

    Export disorders for ADCYAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCYAP1 gene, integrated from 9 sources (see all 621):
    (articles sorted by number of sources associating them with ADCYAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (PubMed id 1730060)1, 2, 3, 9 Hosoya M.... Fujino M. (1992)
    2. Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes. (PubMed id 11968092)1, 2, 4 Gu H.F. (2002)
    3. Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide. (PubMed id 1739432)1, 2, 9 Ohkubo S.... Fujino M. (1992)
    4. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. (PubMed id 19914336)1, 4, 9 Hashimoto R....Kunugi H. (2010)
    5. A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. (PubMed id 2302217)1, 2, 9 Kimura C.... Fujino M. (1990)
    6. Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia. (PubMed id 20414143)1, 4, 9 Koga M....Arinami T. (2010)
    7. Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution. (PubMed id 1483839)1, 2, 9 Inooka H.... Fujino M. (1992)
    8. Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP). (PubMed id 19120039)1, 4, 9 Cummings K.J....Wilson R.J. (2009)
    9. Association analysis of the pituitary adenylate cyclase-activating polypeptide (PACAP/ADCYAP1) gene in bipolar disorder. (PubMed id 18349695)1, 4, 9 Lohoff F.W....Berrettini W.H. (2008)
    10. The neuropeptide genes TAC1, TAC3, TAC4, VIP and PACAP(ADCYAP1), and susceptibility to multiple sclerosis. (PubMed id 17175032)1, 4, 9 Cunningham S....Vandenbroeck K. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 116 HGNC: 241 AceView: ADCYAP1 Ensembl:ENSG00000141433 euGenes: HUgn116
    ECgene: ADCYAP1 Kegg: 116 H-InvDB: ADCYAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCYAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADCYAP1 gene:
    Search GeneIP for patents involving ADCYAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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