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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADCYAP1 Gene

protein-coding GIFtS: 63
GCID: GC18P000895

adenylate cyclase activating polypeptide 1 (pituitary)

Explore 81 diseases affiliated with
ADCYAP1 via

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenylate Cyclase Activating Polypeptide 1 (Pituitary)¹ ²
PACAP¹ ² ³
Pituitary Adenylate Cyclase-Activating Polypeptide²

External Ids:	HGNC: 241¹	Entrez Gene: 116²	Ensembl: ENSG00000141433⁷	OMIM: 102980⁵	UniProtKB: P18509³

Export aliases for ADCYAP1 gene to outside databases

Previous GC identifers: GC18M001066 GC18P000892

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCYAP1:

This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides

stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the

transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress

responses. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Feb 2013)

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509

Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells

summary for ADCYAP1:

Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors

referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1

receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb,

thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the

adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock,

emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human

PAC1 receptor gene has been localized to chromosome 7p14.

Gene Wiki entry for ADCYAP1 (Pituitary adenylate cyclase-activating peptide)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010859.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADCYAP1 gene promoter:
CREB GR AP-1 deltaCREB ATF-2 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADCYAP1 promoter sequence

Search SABiosciences Chromatin IP Primers for ADCYAP1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCYAP1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11

ADCYAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCYAP1 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P000895: view genomic region (about GC identifiers)

Start:	904,944 bp from pter	End:	912,173 bp from pter
Size:	7,230 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509 (See protein sequence)

Recommended Name: Pituitary adenylate cyclase-activating polypeptide precursor

Size: 176 amino acids; 18835 Da

Subunit: Interacts with ADCYAP1R1 (via N-terminal extracellular domain)

Subcellular location: Secreted

3 PDB 3D structures from and Proteopedia for ADCYAP1:

1GEA (3D)

2D2P (3D)

2JOD (3D)

Secondary accessions: B2R7N4 Q52LQ0

Explore the universe of human proteins at neXtProt for ADCYAP1: NX_P18509

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18509

ADCYAP1 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins (2 alternative transcripts):

NP_001093203.1 NP_001108.2

ENSEMBL proteins:

ENSP00000411658 ENSP00000462647

Reactome Protein details: P18509
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	Uscn Proteins for ADCYAP1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005625	soluble fraction	--	--
GO:0043195	terminal bouton	IEA	--

ADCYAP1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADCYAP1 for domains About GeneDecksing

1 InterPro domain/family:

IPR000532 Glucagon_GIP_secretin_VIP

Graphical View of Domain Structure for InterPro Entry P18509

ProtoNet protein and cluster: P18509

1 Blocks protein family: IPB000532 Glucagon/GIP/secretin/VIP

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509

Similarity: Belongs to the glucagon family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509

Function: Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells

Genatlas biochemistry entry for ADCYAP1:

pituitary adenylyl cyclase activating polypeptide (glucagon,VIP family),including 2 isoforms PACAP27 and

PACAP38,expressed in the retinohypothalamus tract (RHT),acting as a pivotal modulator of glutamatergic regulation of

the suprachiasmatic circadian clock

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In Situ Assay
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Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005057	receptor signaling protein activity	IEA	--
GO:0005102	receptor binding	IPI	7680413
GO:0005184	neuropeptide hormone activity	TAS	2302217
GO:0016521	pituitary adenylate cyclase activating polypeptide activity	IDA	9603988
GO:0031858	pituitary adenylate cyclase-activating polypeptide receptor binding	IEA	--

ADCYAP1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ADCYAP1:

Increased cilium length after

Animal Models:
Mouse knock-outs for ADCYAP1: Adcyap1^tm1Clw Adcyap1^tm1Eid Adcyap1^tm1Aba Adcyap1^tm1Nms
10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Adcyap1):

adipose tissue	behavior/neurological	embryogenesis	growth/size	homeostasis/metabolism
liver/biliary system	mortality/aging	muscle	nervous system	reproductive system

ADCYAP1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G beta:gamma signalling through PLC beta

	Glucagon-type ligand receptors	0.52			G alpha (s) signalling events	0.14
	Class B/2 (Secretin family receptors)	0.20

NGF-independant TRKA activation

NGF-independant TRKA activation

1.00

Activation of TRKA receptors

0.83

Signaling by FGFR

NGF signalling via TRKA from the plasma membrane

0.70

Signalling by NGF

0.52

Adenylate cyclase-activating neuropeptides

Adenylate cyclase-activating neuropeptides

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ADCYAP1

Adenylate cyclase-activating neuropeptides

1 BioSystems Pathway for ADCYAP1

SIDS Susceptibility Pathways

5/11 Reactome Pathways for ADCYAP1 (see all 11)

	GPCR downstream signaling
	Glucagon-type ligand receptors
	Signaling by GPCR
	GPCR ligand binding
	NGF signalling via TRKA from the plasma membrane

ADCYAP1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADCYAP1

5/10 Interacting proteins for ADCYAP1 (P18509^{2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DPP4	P27487²^,³	MINT-8090860 I2D: score=1
FAP	Q12884²^,³	MINT-8094219 I2D: score=1
CASP2	P42575³	I2D: score=2
MME	P08473³	I2D: score=2
SCTR	P47872³	I2D: score=2

About this table

Gene Ontology (GO): 5/33 biological process terms (GO ID links to tree view) (see all 33): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001541	ovarian follicle development	IEA	--
GO:0001662	behavioral fear response	IEA	--
GO:0001821	histamine secretion	IEA	--
GO:0002865	negative regulation of acute inflammatory response to antigenic stimulus	IEA	--
GO:0002878	negative regulation of acute inflammatory response to non-antigenic stimulus	IEA	--

ADCYAP1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADCYAP1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADCYAP1 available from Tocris Bioscience About this table

Compound	Action	CAS #
PACAP 1-38	Potent stimulator of adenylyl cyclase	--
PACAP 1-27	Potent stimulator of adenylyl cyclase	[137061-48-4]

1 DrugBank Compound for ADCYAP1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
2,6-Diamino-Hexanoic Acid Amide	--	--	target	--	--

10/112 Novoseek chemical compound relationships for ADCYAP1 gene (see all 112) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pacap 38	96.5	248	12147212 (9), 8752106 (8), 9829998 (7), 15870074 (6) (see all 57)
adenylate	96.4	1584	17940421 (7), 7479307 (6), 1655384 (4), 1324148 (3) (see all 99)
pacaps	91.3	12	8404665 (1), 12716746 (1), 15056941 (1), 8698838 (1) (see all 9)
helospectin	81.2	18	7761627 (5), 8897643 (2), 8564257 (2), 7914821 (1) (see all 6)
forskolin	74.2	60	10595920 (2), 15882914 (2), 10646500 (2), 16455786 (2) (see all 40)
cyclic amp	72.7	120	15800375 (5), 8857610 (4), 8752106 (4), 9681437 (4) (see all 37)
helospectin i	72.5	8	8680719 (3), 7914821 (3)
maxadilan	72.4	12	10657479 (6), 15518905 (3), 15034198 (1), 16888153 (1)
apamin	48.2	7	8071835 (2), 8680719 (1), 8751083 (1), 11207070 (1)
2',5'-dideoxyadenosine	48.2	2	10414962 (1)

Search CenterWatch for drugs/clinical trials and news about ADCYAP1 / PACA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADCYAP1 gene (2 alternative transcripts):

NM_001099733.1 NM_001117.4

Unigene Cluster for ADCYAP1:

Adenylate cyclase activating polypeptide 1 (pituitary)

Hs.531719 [show with all ESTs]

Unigene Representative Sequence: AK095723

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000450565 ENST00000579794(uc010dkg.3 uc010dkh.3) ENST00000269200

ENST00000581602

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Additional cDNA sequence:

AK095723.1 AK294233.1 AK313050.1 BC093837.1 BC101803.1 S83513.1

7 DOTS entries:

DT.110319 DT.405957 DT.95288570 DT.100759469 DT.100022840 DT.91988881 DT.100746685

24/61 AceView cDNA sequences (see all 61):

AI932543 CR603595 T11038 BE220888 BI793247 CD244263 AV703144 AI697629

AA772782 CK820262 AA991809 BF513900 BU783065 BM142250 BX391878 BU071058

BU579487 BM142346 BX333515 BU789076 AA379639 S83513 CA772587 CK820263

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADCYAP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ADCYAP1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Brain

Eye

Gut Tube

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Midbrain dopaminergic-like neurons (Generation of midbra...)

Genevestigator expression for ADCYAP1

SOURCE GeneReport for Unigene cluster: Hs.531719

SABiosciences Expression via Pathway-Focused PCR Array including ADCYAP1:

Obesity in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for ADCYAP1 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADCYAP1¹	adenylate cyclase activating polypeptide 1 (pituitary)	77.19(n) 70.18(a)		408251 NM_001001291.2 NP_001001291.2
lizard (Anolis carolinensis)	Reptilia	ADCYAP1⁶	--	69(a)	1 ↔ 1	4(39653333-39674253)
African clawed frog (Xenopus laevis)	Amphibia	PACAP²	pituitary adenylate cyclase-activating peptide	76.59(n)		AF187877.1
zebrafish (Danio rerio)	Actinopterygii	Dr.10739²	Danio rerio adenylate cyclase-activating peptide mRNA, more	81.19(n)		AF329730.1

ENSEMBL Gene Tree for ADCYAP1 (if available)
TreeFam Gene Tree for ADCYAP1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADCYAP1 gene

VIP²

1 SIMAP similar gene for ADCYAP1 using alignment to 3 protein entries: PACA_HUMAN (see all proteins):

VIP

ADCYAP1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2846582^1,2	C,H	--	902954(+)	`TATCTG/TGGAAA`	1	--	us2k¹		0	--	--	--	--
rs2846583^1,2	C,F,A,H,	--	902965(+)	`AAGCAA/TGCAGA`	1	--	us2k¹		16		NS EA WA NA CSA	772
rs192855863^1,2		--	902992(+)	`TAAATA/GTGAGA`	1	--	us2k¹		0	--	--	--	--
rs182729295^1,2		--	903109(+)	`ATTTTA/CTTTCT`	1	--	us2k¹		0	--	--	--	--
rs11340426^1,2	C,F	--	903131(+)	`TCTTCT/-TTTTT`	1	--	us2k¹ trp³		3		NA CSA	6
rs200885908^1,2		--	903132(+)	`TTCTT-/CTTTTT`	1	--	us2k¹		0	--	--	--	--
rs2515911^1,2	H	--	903154(+)	`AAATAG/AACCTG`	1	--	us2k¹		4		NS EA	400
rs187374899^1,2		--	903219(+)	`GGAAGC/GCTCTG`	1	--	us2k¹		0	--	--	--	--
rs2856964^1,2	H	--	903315(+)	`TGTTAG/AAAACC`	2	--	us2k¹		4		NS EA	410
rs192157378^1,2		--	903325(+)	`CTTCAC/TCAGGT`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADCYAP1 (904944 - 912173 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ADCYAP1
3 CNVs: 50068 50065 50066
1 Indel: 50067
Human Gene Mutation Database (HGMD): ADCYAP1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADCYAP1 for disorders           About GeneDecksing

OMIM gene information: 102980    OMIM disorders: --

20/81 diseases for ADCYAP1 (see all 81):    About MalaCards

post-traumatic stress disorder sudden infant death syndrome carpal tunnel syndrome chronic fatigue syndrome

traumatic brain injury pituitary adenoma major depressive disorder bipolar affective disorder

brain injury hirschsprung's disease anorexia nervosa gliosis

retinal degeneration neuroendocrine tumor prolactinoma cystic fibrosis

paraganglioma bipolar disorder pituitary tumor ependymoma

2 diseases from the University of Copenhagen DISEASES database for ADCYAP1:

Sudden infant death syndrome Vascular disease

10/71 Novoseek disease relationships for ADCYAP1 gene (see all 71) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gulf war syndrome	56.3	1	15922114 (1)
pituitary adenoma	37.1	24	9846969 (5), 10595920 (3), 9285938 (3), 7527412 (2) (see all 6)
pituitary adenoma nonfunctioning	33.9	1	8547947 (1)
pheochromocytoma	33.9	8	2175177 (2), 7759058 (1), 12438166 (1), 10567198 (1) (see all 6)
sudden infant death syndrome	33	5	19120039 (2), 18589006 (1), 15922114 (1)
cholera	26.5	5	1337557 (1), 15109935 (1), 1309195 (1), 11476937 (1)
chronic fatigue syndrome	25.9	1	15922114 (1)
prolactinoma	24.8	3	7479307 (1), 9846969 (1)
shock septic	24.2	10	12794054 (2), 18650785 (2), 11792830 (1), 18098289 (1) (see all 6)
pituitary tumors	22.6	4	7479307 (1), 19236332 (1)

Genetic Association Database (GAD): ADCYAP1
Human Genome Epidemiology (HuGE) Navigator: ADCYAP1 (15 documents)

Export disorders for ADCYAP1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ADCYAP1 gene, integrated from 9 sources (see all 608):
(articles sorted by number of sources associating them with ADCYAP1)

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world of online information

Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (PubMed id 1730060)^{1, 2, 3, 9} Hosoya M.... Fujino M. (1992)
Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes. (PubMed id 11968092)^{1, 2, 4} Gu H.F. (2002)
Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide. (PubMed id 1739432)^{1, 2, 9} Ohkubo S.... Fujino M. (1992)
A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. (PubMed id 2302217)^{1, 2, 9} Kimura C.... Fujino M. (1990)
Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution. (PubMed id 1483839)^{1, 2, 9} Inooka H.... Fujino M. (1992)
Association analysis of the pituitary adenyl cyclase activating peptide gene (PACAP) on chromosome 18p11 with schizophrenia and bipolar disorders. (PubMed id 11515750)^{1, 4, 9} Ishiguro H....Arinami T. (2001)
Solution structure and mutational analysis of pituitary adenylate cyclase-activating polypeptide binding to the extracellular domain of PAC1-RS. (PubMed id 17470806)^{1, 2} Sun C....Olejniczak E.T. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Conformation of a peptide ligand bound to its G-protein coupled receptor. (PubMed id 11175907)^{1, 2} Inooka H.... Shirakawa M. (2001)
Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy. (PubMed id 8504103)^{1, 2} Wray V.... Naruse S. (1993)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 116	HGNC: 241	AceView: ADCYAP1	Ensembl:ENSG00000141433	euGenes: HUgn116
ECgene: ADCYAP1	H-InvDB: ADCYAP1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADCYAP1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADCYAP1 gene
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Patent Information for ADCYAP1 gene:
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ADCYAP1 Gene

adenylate cyclase activating polypeptide 1 (pituitary)

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ADCYAP1 Gene

adenylate cyclase activating polypeptide 1 (pituitary)

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