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ADCYAP1 Gene

protein-coding GIFtS: 59

GC18P000895

adenylate cyclase activating polypeptide 1 (pituitary)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
MGC126852 ^²
OTTHUMP00000162201 ^²
PACAP ^¹, ², ³

Descriptions
adenylate cyclase activating polypeptide ^²
adenylate cyclase activating polypeptide 1 (pituitary) ^²

External Ids
HGNC: 241¹
Entrez Gene: 116²
UniProtKB: P18509³
Ensembl: ENSG00000141433⁷

Search outside databases for aliases for ADCYAP1 gene

Previous GC identifers: GC18M001066 GC18P000892

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADCYAP1:

This gene encodes adenylate cyclase activating polypeptide 1. Mediated by adenylate cyclase

activating polypeptide 1 receptors, this polypeptide stimulates adenylate cyclase and subsequently

increases the cAMP level in target cells. Adenylate cyclase activating polypeptide 1 is not only a

hypophysiotropic hormone, but also functions as a neurotransmitter and neuromodulator. In

addition, it plays a role in paracrine and autocrine regulation of certain types of cells. This

gene encodes three different mature peptides, including two isotypes, a shorter form and a longer

form. Two transcript variants encoding the same protein have been found for this gene. [provided

by RefSeq]

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509

Function: Stimulates adenylate cyclase in pituitary cells

Gene Wiki entry for ADCYAP1 (Pituitary_adenylate_cyclase_activating_peptide)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADCYAP1 gene

Entrez Gene cytogenetic band: 18p11 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11

ADCYAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P000895: (about GC identifiers)

Start:	894,944 bp from pter
End:	902,173 bp from pter
Size:	7,230 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_010859.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PACA_HUMAN, P18509 (See protein sequence)

Recommended Name: Pituitary adenylate cyclase-activating polypeptide precursor

Size: 176 amino acids; 18835 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1GEA (3D)

2D2P (3D)

2JOD (3D)

Secondary accessions: B2R7N4 Q52LQ0

REFSEQ proteins (2 alternative transcripts):

NP_001093203.1 NP_001108.2

ENSEMBL proteins:

ENSP00000383078 ENSP00000269200

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for ADCYAP1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PACAP)
	Human Recombinant Proteins from Abnova (ADCYAP1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005625	soluble fraction	TAS	10698193

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Antibodies for ADCYAP1:

	Invitrogen Antibodies for ADCYAP1
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (PACAP), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ADCYAP1

Assays for ADCYAP1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P18509

ProtoNet protein and cluster: P18509

1 Blocks protein family: IPB000532 Glucagon/GIP/secretin/VIP

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509

Similarity: Belongs to the glucagon family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADCYAP1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001099733

Applied Biosystems Silencer® siRNAs for ADCYAP1

Sigma-Aldrich siRNA for ADCYAP1

Sigma-Aldrich shRNA for ADCYAP1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ADCYAP1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099733
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099733
untagged cDNA clones in CMV expression vector (see all 2): NM_001099733

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001117

UniProtKB/Swiss-Prot: PACA_HUMAN, P18509

Function: Stimulates adenylate cyclase in pituitary cells

Genatlas biochemistry entry for ADCYAP1:

pituitary adenylyl cyclase activating polypeptide (glucagon,VIP family),including 2 isoforms

PACAP27 and PACAP38,expressed in the retinohypothalamus tract (RHT),acting as a pivotal modulator

of glutamatergic regulation of the suprachiasmatic circadian clock

10 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Adcyap1):

adipose tissue	behavior/neurological	embryogenesis	growth/size	homeostasis/metabolism
lethality-postnatal	liver/biliary system	muscle	nervous system	reproductive system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005184	neuropeptide hormone activity	TAS	2302217

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ADCYAP1 (Your Favorite Gene powered by Ingenuity)

Circadian Rhythm Signaling

GeneDecks ADCYAP1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADCYAP1

5/37 Interacting proteins for ADCYAP1 (ENSP00000269200³) via UniProtKB, MINT, and/or STRING (see all 37 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADCYAP1R1	ENSP00000306620³	STRING (score=.996)
VIPR2	ENSP00000262178³	STRING (score=.994)
VIPR1	ENSP00000327246³	STRING (score=.992)
DUSP2	ENSP00000288943³	STRING (score=.953)
NTRK1	ENSP00000351486³	STRING (score=.949)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	EXP	16939974
GO:0007190	activation of adenylate cyclase activity	TAS	1730060
GO:0007267	cell-cell signaling	TAS	2302217
GO:0007565	female pregnancy	TAS	10698193
GO:0045786	negative regulation of cell cycle	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for ADCYAP1

Browse Small Molecules at Sigma-Aldrich

Compounds for ADCYAP1 available from Tocris Bioscience

Compound	Action	CAS number
PACAP 1-38	Potent stimulator of adenylyl cyclase
PACAP 1-27	Potent stimulator of adenylyl cyclase	[137061-48-4]

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10/47 Novoseek chemical compound relationships for ADCYAP1 gene (see all 47 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pacap 38	96.31	239	12147212 (9), 8752106 (8), 9829998 (7), 15870074 (6) (see all 54)
helospectin	81.48	17	7761627 (5), 8897643 (2), 8564257 (2), 7914821 (1) (see all 6)
forskolin	74.36	57	10595920 (2), 15882914 (2), 10646500 (2), 16455786 (2) (see all 38)
helospectin i	72.88	8	8680719 (3), 7914821 (3)
cyclic amp	72.36	115	15800375 (5), 8857610 (4), 8752106 (4), 9681437 (4) (see all 35)
apamin	49.28	7	8071835 (2), 8680719 (1), 8751083 (1), 11207070 (1)
2',5'-dideoxyadenosine	49.03	2	10414962 (1)
dbc-amp	45.57	9	15308290 (3), 8857610 (1), 12692897 (1), 15605988 (1) (see all 5)
ghrp	44.64	6	1346381 (4), 8721987 (1)
catecholamine	43.82	36	15518890 (3), 10567198 (3), 8993404 (2), 10974664 (2) (see all 18)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADCYAP1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001099733

Sigma-Aldrich siRNA for ADCYAP1

Sigma-Aldrich shRNA for ADCYAP1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001099733 NM_001117

REFSEQ mRNAs for ADCYAP1 gene (2 alternative transcripts):

NM_001099733.1 NM_001117.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001099733 NM_001117

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001099733
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001099733
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001099733

Additional cDNA sequence:

AK095723.1 AK294233.1 AK313050.1 BC093837.1 BC101803.1 CR603595.1 S83513.1

7 DOTS entries:

DT.110319 DT.405957 DT.95288570 DT.91988881 DT.100759469 DT.100022840 DT.100746685

24/61 AceView cDNA sequences (see all 61 ):

BE220888 CR603595 BI793247 AV703144 AI697629 CD244263 T11038 AI932543

BM142346 AA379639 BU783065 BM142250 BF513900 BU789076 BU579487 BF448881

BM354129 BQ549183 AA081575 BM354004 CK820263 BU071058 CK820262 NM_001117

highest scoring ESTs for ADCYAP1:

AA081575 AA379639 AA772782 AA772803 AL580406 AW590448 AW960236 BE049305 BF432289 BF513900

Unigene Cluster for ADCYAP1:

Adenylate cyclase activating polypeptide 1 (pituitary)

Hs.531719 [show with all ESTs]

Unigene Representative Sequence: AK095723

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000400219 ENST00000269200

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADCYAP1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADCYAP1

¹ / ² / ³

6 probe-sets matching ADCYAP1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
48934_at²	U95-B	1	1.00	1.00	0.99	0.81	--	--	--	--	--
36754_at²^{, 3}	U95-A	1	1.00	1.00	0.85	1.22	X60435	0.20	1.00	0.72	1
230237_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
206281_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001117	0.60	1.00	0.82	1
230237_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206281_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADCYAP1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.531719
Expression variation in blood from EXPOLDB for ADCYAP1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ADCYAP1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADCYAP1¹	--	adenylate cyclase activating polypeptide 1 (pituitary)	89.39(n) 85.8(a)	607433 XM_844098.1 XP_849191.1
chimpanzee (Pan troglodytes)	ADCYAP1¹	--	adenylate cyclase activating polypeptide 1 (pituitary)	94.89(n) 90.34(a)	468489 XM_001147286.1 XP_001147286.1
cow (Bos taurus)	ADCYAP1¹	--	adenylate cyclase activating polypeptide 1 (pituitary)	82.95(n) 77.27(a)	615187 NM_001046555.1 NP_001040020.1
rat (Rattus norvegicus)	Adcyap1¹	--	adenylate cyclase activating polypeptide 1 (pituitary)	85.52(n) 82.29(a)	24166 NM_016989.1 NP_058685.1
mouse (Mus musculus)	Adcyap1^{1, 5}	17⁵	adenylate cyclase activating polypeptide 1^{1, 5}	85.52(n)¹ 82.86(a)¹	11516¹ NM_009625.2¹ NP_033755.1¹ AB010149⁵ AI323434⁵ (see all 10)

About this table Species with no ortholog for ADCYAP1

ENSEMBL Gene Tree for ADCYAP1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADCYAP1 gene

VIP²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/98 NCBI SNPs in ADCYAP1 are shown (see all 98 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 81)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1893154^1,2	A,C,F,H	895125(-)	`CGCGAC/TGCCAA`	2	--	ng5¹ int¹ tfbs³		6		NA EU EA WA	586
	rs2846583^1,2	A,C,F,H	892965(+)	`AAGCAA/TGCAGA`	1	--	ng5¹		4		EU EA WA	396
	rs1610037^1,2	A,C,F,H	900635(+)	`TCCCAA/GTGGTC`	2	--	ut3¹ ese³		9		MN EU EA WA	1020
	rs2846584^1,2	A,C,F,H	894054(+)	`AGCTCC/TGATTG`	2	--	ng5¹		4		EA EU	1778
	rs2856966^1,2	C,F,H	897710(+)	`CTTCGA/GTGGCT`	2	D/G	mis¹		4		EU EA WA	410
--	rs2231189^1,2	C,F,H	899669(+)	`ACAGCC/TCTGAC`	2	--	ut3¹ ese³		8		EU EA WA	838
	rs2856965^1,2	A,C	894097(+)	`TAATTA/GTATAG`	2	--	ng5¹		0	--	--	--	--
--	rs2688998^1,2	A,C	893424(+)	`TTCTCA/GCCCCA`	2	--	ng5¹		0	--	--	--	--
	rs2231181^1,2	A,C	894766(+)	`TCCGCC/GCTTCA`	2	--	ng5¹		0	--	--	--	--
	rs2688999^1,2	A,C	893429(+)	`ACCCCA/CAAATT`	2	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for ADCYAP1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 102980

10/70 Novoseek disease relationships for ADCYAP1 gene (see all 70 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gulf war syndrome	57.04	1	15922114 (1)
pituitary adenoma	38.53	24	9846969 (5), 10595920 (3), 9285938 (3), 7527412 (2) (see all 6)
pituitary adenoma nonfunctioning	35.72	1	8547947 (1)
pheochromocytoma	35.24	8	2175177 (2), 7759058 (1), 12438166 (1), 10567198 (1) (see all 6)
sudden infant death syndrome	34.10	5	19120039 (2), 18589006 (1), 15922114 (1)
cholera	27.72	5	1337557 (1), 15109935 (1), 1309195 (1), 11476937 (1)
prolactinoma	26.27	3	7479307 (1), 9846969 (1)
shock septic	26.05	10	12794054 (2), 18650785 (2), 11792830 (1), 18098289 (1) (see all 6)
pituitary tumors	23.80	4	7479307 (1), 19236332 (1)
chronic fatigue syndrome	21.95	1	15922114 (1)

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Genetic Association Database: ADCYAP1
Human Genome Epidemiology Navigator: ADCYAP1 (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/504 PubMed articles for ADCYAP1 gene (see all 504 ):

Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (PubMed id 1730060)^{1, 2, 3, 4} Hosoya M.... Fujino M. (1992)
Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes. (PubMed id 11968092)^{3, 4, 6} Gu H.F. (2002)
Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide. (PubMed id 1739432)^{1, 3, 4} Ohkubo S.... Fujino M. (1992)
A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. (PubMed id 2302217)^{1, 3, 4} Kimura C.... Fujino M. (1990)
Association analysis of the pituitary adenyl cyclase activating peptide gene (PACAP) on chromosome 18p11 with schizophrenia and bipolar disorders. (PubMed id 11515750)^{1, 3, 6} Ishiguro H....Arinami T. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy. (PubMed id 8504103)^{3, 4} Wray V.... Naruse S. (1993)
Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution. (PubMed id 1483839)^{3, 4} Inooka H.... Fujino M. (1992)
PACAP is expressed in secretory granules of insulin and glucagon cells in human and rodent pancreas. Evidence for generation of cAMP compartments uncoupled from hormone release in diabetic islets. (PubMed id 12686458)^{1, 3} Portela-Gomes G.M....Abdel-Halim S.M. (2003)
Pituitary adenylate cyclase-activating polypeptide (PACAP) and PACAP-receptor type 1 expression in rat and human placenta. (PubMed id 10698193)^{1, 3} Scaldaferri M.L....Moretti C. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 116	HGNC: 241	AceView: ADCYAP1	Ensembl:ENSG00000141433	euGenes: HUgn116
ECgene: ADCYAP1	H-InvDB: ADCYAP1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADCYAP1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ADCYAP1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADCYAP1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADCYAP1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for ADCYAP1
	Lentivirus-delivered shRNAs for ADCYAP1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Tocris compounds for ADCYAP1

	Drugs for ADCYAP1
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ADCYAP1 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ADCYAP1

Summaries
for ADCYAP1

Genomic Location
for ADCYAP1

Proteins
for ADCYAP1

Protein Domains/
Families
for ADCYAP1

Gene Function
for ADCYAP1

Pathways & Interactions
for ADCYAP1

Drugs & Compounds
for ADCYAP1

Transcripts
for ADCYAP1

Expression
for ADCYAP1

Orthologs
for ADCYAP1

Paralogs
for ADCYAP1

SNPs/Variants
for ADCYAP1

Disorders & Mutations
for ADCYAP1

Medical News
for ADCYAP1

Publications
for ADCYAP1

Search for ADCYAP1

Genome Databases showing ADCYAP1

Other Databases showing ADCYAP1

Specialized Databases showing ADCYAP1

Licensable Technologies
for ADCYAP1

Services
for ADCYAP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADCYAP1 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ADCYAP1

Summariesfor ADCYAP1

Genomic Locationfor ADCYAP1

Proteinsfor ADCYAP1

Protein Domains/Familiesfor ADCYAP1

Gene Functionfor ADCYAP1

Pathways & Interactionsfor ADCYAP1

Drugs & Compoundsfor ADCYAP1

Transcriptsfor ADCYAP1

Expression for ADCYAP1

Orthologsfor ADCYAP1

Paralogsfor ADCYAP1

SNPs/Variantsfor ADCYAP1

Disorders & Mutationsfor ADCYAP1

Medical Newsfor ADCYAP1

Publicationsfor ADCYAP1

Search for ADCYAP1

Genome Databases showing ADCYAP1

Other Databases showing ADCYAP1

Specialized Databases showing ADCYAP1

Licensable Technologiesfor ADCYAP1

Servicesfor ADCYAP1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADCYAP1

Summaries
for ADCYAP1

Genomic Location
for ADCYAP1

Proteins
for ADCYAP1

Protein Domains/
Families
for ADCYAP1

Gene Function
for ADCYAP1

Pathways & Interactions
for ADCYAP1

Drugs & Compounds
for ADCYAP1

Transcripts
for ADCYAP1

Expression
for ADCYAP1

Orthologs
for ADCYAP1

Paralogs
for ADCYAP1

SNPs/Variants
for ADCYAP1

Disorders & Mutations
for ADCYAP1

Medical News
for ADCYAP1

Publications
for ADCYAP1

Licensable Technologies
for ADCYAP1

Services
for ADCYAP1