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Aliases for ADCYAP1 Gene

Aliases for ADCYAP1 Gene

  • Adenylate Cyclase Activating Polypeptide 1 2 3
  • Adenylate Cyclase Activating Polypeptide 1 (Pituitary) 2 3 5
  • Pituitary Adenylate Cyclase Activating Polypeptide 2 3
  • Prepro-PACAP 2 3
  • PACAP 3 4

External Ids for ADCYAP1 Gene

Previous GeneCards Identifiers for ADCYAP1 Gene

  • GC18M001066
  • GC18P000892

Summaries for ADCYAP1 Gene

Entrez Gene Summary for ADCYAP1 Gene

  • This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

GeneCards Summary for ADCYAP1 Gene

ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1) is a Protein Coding gene. Diseases associated with ADCYAP1 include Persian Gulf Syndrome and Sudden Infant Death Syndrome. Among its related pathways are Presynaptic function of Kainate receptors and Signaling by GPCR. GO annotations related to this gene include receptor binding and receptor signaling protein activity. An important paralog of this gene is VIP.

UniProtKB/Swiss-Prot for ADCYAP1 Gene

  • Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

Tocris Summary for ADCYAP1 Gene

  • Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.

Gene Wiki entry for ADCYAP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCYAP1 Gene

Genomics for ADCYAP1 Gene

Regulatory Elements for ADCYAP1 Gene

Enhancers for ADCYAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADCYAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADCYAP1 Gene

904,345 bp from pter
912,172 bp from pter
7,828 bases
Plus strand

Genomic View for ADCYAP1 Gene

Genes around ADCYAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCYAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCYAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCYAP1 Gene

Proteins for ADCYAP1 Gene

  • Protein details for ADCYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pituitary adenylate cyclase-activating polypeptide
    Protein Accession:
    Secondary Accessions:
    • B2R7N4
    • Q52LQ0

    Protein attributes for ADCYAP1 Gene

    176 amino acids
    Molecular mass:
    18835 Da
    Quaternary structure:
    • Interacts with ADCYAP1R1 (via N-terminal extracellular domain).

    Three dimensional structures from OCA and Proteopedia for ADCYAP1 Gene

neXtProt entry for ADCYAP1 Gene

Proteomics data for ADCYAP1 Gene at MOPED

Post-translational modifications for ADCYAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCYAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ADCYAP1 (PACAP/ADCYAP1)
  • Abcam antibodies for PACAP

No data available for DME Specific Peptides for ADCYAP1 Gene

Domains & Families for ADCYAP1 Gene

Gene Families for ADCYAP1 Gene

Protein Domains for ADCYAP1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glucagon family.
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with ADCYAP1: view

Function for ADCYAP1 Gene

Molecular function for ADCYAP1 Gene

GENATLAS Biochemistry:
pituitary adenylyl cyclase activating polypeptide (glucagon,VIP family),including 2 isoforms PACAP27 and PACAP38,expressed in the retinohypothalamus tract (RHT),acting as a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock
UniProtKB/Swiss-Prot Function:
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.
genes like me logo Genes that share phenotypes with ADCYAP1: view

Animal Models for ADCYAP1 Gene

MGI Knock Outs for ADCYAP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCYAP1 Gene

Localization for ADCYAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCYAP1 Gene


Subcellular locations from

Jensen Localization Image for ADCYAP1 Gene COMPARTMENTS Subcellular localization image for ADCYAP1 gene
Compartment Confidence
extracellular 5
cytosol 3
mitochondrion 2
nucleus 2
plasma membrane 2
cytoskeleton 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ADCYAP1 Gene

Pathways & Interactions for ADCYAP1 Gene

genes like me logo Genes that share pathways with ADCYAP1: view

Pathways by source for ADCYAP1 Gene

SIGNOR curated interactions for ADCYAP1 Gene


Gene Ontology (GO) - Biological Process for ADCYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development IEA --
GO:0001662 behavioral fear response IEA --
GO:0001821 histamine secretion IEA --
GO:0002865 negative regulation of acute inflammatory response to antigenic stimulus IEA --
GO:0007190 activation of adenylate cyclase activity TAS 1730060
genes like me logo Genes that share ontologies with ADCYAP1: view

Drugs & Compounds for ADCYAP1 Gene

(66) Drugs for ADCYAP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2,6-Diamino-Hexanoic Acid Amide Experimental Pharma Target 0

(50) Additional Compounds for ADCYAP1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PACAP 1-27
PACAP 1-38
PACAP 6-38

(3) Tocris Compounds for ADCYAP1 Gene

Compound Action Cas Number
PACAP 1-27 Potent stimulator of adenylyl cyclase 127317-03-7
PACAP 1-38 Potent stimulator of adenylyl cyclase 137061-48-4
PACAP 6-38 Potent PAC1 receptor antagonist 143748-18-9
genes like me logo Genes that share compounds with ADCYAP1: view

Transcripts for ADCYAP1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADCYAP1 Gene

No ASD Table

Relevant External Links for ADCYAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCYAP1 Gene

mRNA expression in normal human tissues for ADCYAP1 Gene

mRNA differential expression in normal tissues according to GTEx for ADCYAP1 Gene

This gene is overexpressed in Brain - Hypothalamus (x10.9), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for ADCYAP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCYAP1 Gene

SOURCE GeneReport for Unigene cluster for ADCYAP1 Gene Hs.531719

genes like me logo Genes that share expression patterns with ADCYAP1: view

Protein tissue co-expression partners for ADCYAP1 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ADCYAP1 Gene

Orthologs for ADCYAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADCYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCYAP1 35
  • 82.95 (n)
  • 77.27 (a)
  • 81 (a)
(Canis familiaris)
Mammalia ADCYAP1 35
  • 89.39 (n)
  • 85.8 (a)
(Mus musculus)
Mammalia Adcyap1 35
  • 85.52 (n)
  • 82.86 (a)
Adcyap1 16
Adcyap1 36
  • 83 (a)
(Pan troglodytes)
Mammalia ADCYAP1 35
  • 94.89 (n)
  • 90.34 (a)
  • 90 (a)
(Rattus norvegicus)
Mammalia Adcyap1 35
  • 85.52 (n)
  • 82.29 (a)
(Monodelphis domestica)
Mammalia ADCYAP1 36
  • 66 (a)
(Ornithorhynchus anatinus)
Mammalia ADCYAP1 36
  • 36 (a)
(Gallus gallus)
Aves ADCYAP1 35
  • 76.61 (n)
  • 69.59 (a)
  • 52 (a)
(Anolis carolinensis)
Reptilia ADCYAP1 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adcyap1 35
  • 69.34 (n)
  • 66.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia PACAP 35
(Danio rerio)
Actinopterygii Dr.10739 35
adcyap1a 36
  • 41 (a)
adcyap1b 36
  • 55 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8047 35
Species with no ortholog for ADCYAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADCYAP1 Gene

Gene Tree for ADCYAP1 (if available)
Gene Tree for ADCYAP1 (if available)

Paralogs for ADCYAP1 Gene

Paralogs for ADCYAP1 Gene

(1) SIMAP similar genes for ADCYAP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADCYAP1: view

Variants for ADCYAP1 Gene

Sequence variations from dbSNP and Humsavar for ADCYAP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs2856966 - 907,709(+) CTTCG(A/G)TGGCT reference, missense
rs1610037 -- 910,634(+) TCCCA(A/G)TGGTC utr-variant-3-prime
rs8086678 -- 905,886(+) TTGAG(C/T)GTGAA intron-variant
rs1893153 -- 905,202(-) AAAAA(A/T)ATATA intron-variant, utr-variant-5-prime
rs1893154 -- 905,124(-) CGCGA(C/T)GCCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADCYAP1 Gene

Variant ID Type Subtype PubMed ID
nsv909288 CNV Loss 21882294
nsv528169 CNV Loss 19592680
nsv518677 CNV Loss 19592680
nsv517252 CNV Loss 19592680

Variation tolerance for ADCYAP1 Gene

Residual Variation Intolerance Score: 51.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCYAP1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCYAP1 Gene

Disorders for ADCYAP1 Gene

MalaCards: The human disease database

(8) MalaCards diseases for ADCYAP1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
persian gulf syndrome
  • gulf war syndrome
sudden infant death syndrome
  • cot death
post-traumatic stress disorder
  • traumatic neurosis
urethral intrinsic sphincter deficiency
  • intrinsic sphincter deficiency [isd]
menkes disease
  • copper transport disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ADCYAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADCYAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADCYAP1 Gene

Publications for ADCYAP1 Gene

  1. Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (PMID: 1730060) Hosoya M. … Fujino M. (Biochim. Biophys. Acta 1992) 2 3 4 23 67
  2. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. (PMID: 19914336) Hashimoto R. … Kunugi H. (Neurosci. Lett. 2010) 3 23
  3. Luteinizing hormone-stimulated pituitary adenylate cyclase-activating polypeptide system and its role in progesterone production in human luteinized granulosa cells. (PMID: 19926922) Park H.J. … Chun S.Y. (Endocr. J. 2010) 3 23
  4. Pituitary adenylate cyclase-activating polypeptide ameliorates cisplatin-induced acute kidney injury. (PMID: 20034524) Li M. … Batuman V. (Peptides 2010) 3 23
  5. Sudden infant death syndrome (SIDS) in African Americans: polymorphisms in the gene encoding the stress peptide pituitary adenylate cyclase-activating polypeptide (PACAP). (PMID: 19120039) Cummings K.J. … Wilson R.J. (Acta Paediatr. 2009) 3 23

Products for ADCYAP1 Gene

Sources for ADCYAP1 Gene