Aliases for ADCYAP1 Gene
External Ids for ADCYAP1 Gene
Previous GeneCards Identifiers for ADCYAP1 Gene
This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
GeneCards Summary for ADCYAP1 Gene
ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1 (Pituitary)) is a Protein Coding gene. Diseases associated with ADCYAP1 include post-traumatic stress disorder and chronic fatigue syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include receptor binding and neuropeptide hormone activity. An important paralog of this gene is VIP.
UniProtKB/Swiss-Prot for ADCYAP1 Gene
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.
Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the central nervous system, particularly in the olfactory bulb, thalamus, hypothalamus, dentate gyrus and granule cells of the cerebellum. They are also found in the adrenal medulla and pancreas. PAC1 receptors are involved in daytime regulation of the biological clock, emotional control of behavior, anxiolysis and control of adrenal medulla catecholamine release. The human PAC1 receptor gene has been localized to chromosome 7p14.