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Aliases for ADCYAP1 Gene

Aliases for ADCYAP1 Gene

  • Adenylate Cyclase Activating Polypeptide 1 (Pituitary) 2 3
  • Prepro-PACAP 2 3
  • PACAP 3 4

External Ids for ADCYAP1 Gene

Previous GeneCards Identifiers for ADCYAP1 Gene

  • GC18M001066
  • GC18P000892

Summaries for ADCYAP1 Gene

Entrez Gene Summary for ADCYAP1 Gene

  • This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

GeneCards Summary for ADCYAP1 Gene

ADCYAP1 (Adenylate Cyclase Activating Polypeptide 1 (Pituitary)) is a Protein Coding gene. Diseases associated with ADCYAP1 include persian gulf syndrome and holoprosencephaly-3. Among its related pathways are Signaling by GPCR and Interleukin receptor SHC signaling. GO annotations related to this gene include receptor binding and receptor signaling protein activity. An important paralog of this gene is VIP.

UniProtKB/Swiss-Prot for ADCYAP1 Gene

  • Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

Tocris Summary for ADCYAP1 Gene

  • Pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are Gs-protein-coupled receptors referred to as PAC1. The endogenous ligand, PACAP, also activates the VIP receptors, VPAC1 and VPAC2. PAC1 receptors are predominantly expressed in the CNS.

Gene Wiki entry for ADCYAP1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCYAP1 Gene

Genomics for ADCYAP1 Gene

Regulatory Elements for ADCYAP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCYAP1 Gene

Chromosome:
18
Start:
904,345 bp from pter
End:
912,172 bp from pter
Size:
7,828 bases
Orientation:
Plus strand

Genomic View for ADCYAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCYAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCYAP1 Gene

Proteins for ADCYAP1 Gene

  • Protein details for ADCYAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18509-PACA_HUMAN
    Recommended name:
    Pituitary adenylate cyclase-activating polypeptide
    Protein Accession:
    P18509
    Secondary Accessions:
    • B2R7N4
    • Q52LQ0

    Protein attributes for ADCYAP1 Gene

    Size:
    176 amino acids
    Molecular mass:
    18835 Da
    Quaternary structure:
    • Interacts with ADCYAP1R1 (via N-terminal extracellular domain).

    Three dimensional structures from OCA and Proteopedia for ADCYAP1 Gene

neXtProt entry for ADCYAP1 Gene

Proteomics data for ADCYAP1 Gene at MOPED

Post-translational modifications for ADCYAP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCYAP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for ADCYAP1 (PACAP/ADCYAP1)

No data available for DME Specific Peptides for ADCYAP1 Gene

Domains & Families for ADCYAP1 Gene

Gene Families for ADCYAP1 Gene

Protein Domains for ADCYAP1 Gene

Graphical View of Domain Structure for InterPro Entry

P18509

UniProtKB/Swiss-Prot:

PACA_HUMAN :
  • Belongs to the glucagon family.
Family:
  • Belongs to the glucagon family.
genes like me logo Genes that share domains with ADCYAP1: view

Function for ADCYAP1 Gene

Molecular function for ADCYAP1 Gene

GENATLAS Biochemistry:
pituitary adenylyl cyclase activating polypeptide (glucagon,VIP family),including 2 isoforms PACAP27 and PACAP38,expressed in the retinohypothalamus tract (RHT),acting as a pivotal modulator of glutamatergic regulation of the suprachiasmatic circadian clock
UniProtKB/Swiss-Prot Function:
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

Gene Ontology (GO) - Molecular Function for ADCYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005057 receptor signaling protein activity IEA --
GO:0005102 receptor binding IPI 7680413
GO:0005179 hormone activity --
GO:0005184 neuropeptide hormone activity IDA 23800469
GO:0005515 protein binding IPI 25451228
genes like me logo Genes that share ontologies with ADCYAP1: view
genes like me logo Genes that share phenotypes with ADCYAP1: view

Animal Models for ADCYAP1 Gene

MGI Knock Outs for ADCYAP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCYAP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ADCYAP1 Gene

Localization for ADCYAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCYAP1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCYAP1 Gene COMPARTMENTS Subcellular localization image for ADCYAP1 gene
Compartment Confidence
extracellular 5
cytosol 2
nucleus 2
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADCYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular IMP 23800469
genes like me logo Genes that share ontologies with ADCYAP1: view

Pathways & Interactions for ADCYAP1 Gene

genes like me logo Genes that share pathways with ADCYAP1: view

Pathways by source for ADCYAP1 Gene

1 Qiagen pathway for ADCYAP1 Gene
1 BioSystems pathway for ADCYAP1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for ADCYAP1 Gene

Activates:

Gene Ontology (GO) - Biological Process for ADCYAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS --
GO:0007190 activation of adenylate cyclase activity TAS --
GO:0007218 neuropeptide signaling pathway IDA 23800469
GO:0007267 cell-cell signaling TAS 2302217
GO:0007565 female pregnancy TAS 10698193
genes like me logo Genes that share ontologies with ADCYAP1: view

Drugs & Compounds for ADCYAP1 Gene

(66) Drugs for ADCYAP1 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Apomorphine Approved, Investigational Pharma Activation, Activator 32
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Bumetanide Approved Pharma Inhibition, Inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) cotransporter inhibitor 13
Carbachol Approved Pharma Full agonist, Agonist 3
Clonidine Approved Pharma Partial agonist, Agonist 177

(48) Additional Compounds for ADCYAP1 Gene - From: NovoSeek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PACAP 6-38
143748-18-9
2,5-Dideoxyadenosine
8-bromo-cyclic amp
Actinomycin D
adenylate
genes like me logo Genes that share compounds with ADCYAP1: view

Transcripts for ADCYAP1 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCYAP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCYAP1 Gene

No ASD Table

Relevant External Links for ADCYAP1 Gene

GeneLoc Exon Structure for
ADCYAP1
ECgene alternative splicing isoforms for
ADCYAP1

Expression for ADCYAP1 Gene

mRNA expression in normal human tissues for ADCYAP1 Gene

mRNA differential expression in normal tissues according to GTEx for ADCYAP1 Gene

This gene is overexpressed in Brain - Hypothalamus (x10.9), Brain - Anterior cingulate cortex (BA24) (x4.8), and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for ADCYAP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCYAP1 Gene



SOURCE GeneReport for Unigene cluster for ADCYAP1 Gene Hs.531719

genes like me logo Genes that share expression patterns with ADCYAP1: view

Protein tissue co-expression partners for ADCYAP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADCYAP1 Gene

Orthologs for ADCYAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADCYAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADCYAP1 35
  • 82.95 (n)
  • 77.27 (a)
ADCYAP1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCYAP1 35
  • 89.39 (n)
  • 85.8 (a)
mouse
(Mus musculus)
Mammalia Adcyap1 35
  • 85.52 (n)
  • 82.86 (a)
Adcyap1 16
Adcyap1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADCYAP1 35
  • 94.89 (n)
  • 90.34 (a)
PACAP 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcyap1 35
  • 85.52 (n)
  • 82.29 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCYAP1 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCYAP1 36
  • 36 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCYAP1 35
  • 76.61 (n)
  • 69.59 (a)
ADCYAP1 36
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCYAP1 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcyap1 35
  • 69.34 (n)
  • 66.42 (a)
African clawed frog
(Xenopus laevis)
Amphibia PACAP 35
zebrafish
(Danio rerio)
Actinopterygii Dr.10739 35
adcyap1a 36
  • 41 (a)
OneToMany
adcyap1b 36
  • 55 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8047 35
Species with no ortholog for ADCYAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADCYAP1 Gene

ENSEMBL:
Gene Tree for ADCYAP1 (if available)
TreeFam:
Gene Tree for ADCYAP1 (if available)

Paralogs for ADCYAP1 Gene

Paralogs for ADCYAP1 Gene

(1) SIMAP similar genes for ADCYAP1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ADCYAP1: view

Variants for ADCYAP1 Gene

Sequence variations from dbSNP and Humsavar for ADCYAP1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs545996382 -- 905,088(+) AAAGC(G/T)ACCGG intron-variant, upstream-variant-2KB
rs546028753 -- 911,250(+) TGTTT(C/G)CTGTC utr-variant-3-prime
rs546057237 -- 904,008(+) ATTTA(A/T)TAATA upstream-variant-2KB
rs546593531 -- 906,291(+) GTTCC(C/G)GGAGG intron-variant
rs546726892 -- 906,567(+) CCGGG(C/T)CAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCYAP1 Gene

Variant ID Type Subtype PubMed ID
nsv909288 CNV Loss 21882294
nsv528169 CNV Loss 19592680
nsv518677 CNV Loss 19592680
nsv517252 CNV Loss 19592680

Variation tolerance for ADCYAP1 Gene

Residual Variation Intolerance Score: 51.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.94; 74.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCYAP1 Gene

HapMap Linkage Disequilibrium report
ADCYAP1
Human Gene Mutation Database (HGMD)
ADCYAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCYAP1 Gene

Disorders for ADCYAP1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ADCYAP1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
persian gulf syndrome
  • gulf war syndrome
holoprosencephaly-3
  • hpe3
urethral intrinsic sphincter deficiency
  • intrinsic sphincter deficiency
post-traumatic stress disorder
  • traumatic neurosis
sudden infant death syndrome
  • cot death
- elite association

Relevant External Links for ADCYAP1

Genetic Association Database (GAD)
ADCYAP1
Human Genome Epidemiology (HuGE) Navigator
ADCYAP1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCYAP1
genes like me logo Genes that share disorders with ADCYAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADCYAP1 Gene

Publications for ADCYAP1 Gene

  1. Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. (PMID: 1730060) Hosoya M. … Fujino M. (Biochim. Biophys. Acta 1992) 2 23 67
  2. Possible association between the pituitary adenylate cyclase-activating polypeptide (PACAP) gene and major depressive disorder. (PMID: 19914336) Hashimoto R. … Kunugi H. (Neurosci. Lett. 2010) 23 67
  3. Luteinizing hormone-stimulated pituitary adenylate cyclase-activating polypeptide system and its role in progesterone production in human luteinized granulosa cells. (PMID: 19926922) Park H.J. … Chun S.Y. (Endocr. J. 2010) 23 67
  4. PACAP/PAC1R signaling modulates acetylcholine release at neuronal nicotinic synapses. (PMID: 19958833) Pugh P.C. … Margiotta J.F. (Mol. Cell. Neurosci. 2010) 23 67
  5. Pituitary adenylate cyclase-activating polypeptide ameliorates cisplatin-induced acute kidney injury. (PMID: 20034524) Li M. … Batuman V. (Peptides 2010) 23 67

Products for ADCYAP1 Gene

Sources for ADCYAP1 Gene

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