Aliases for ADCY9 Gene
Aliases for ADCY9 Gene
External Ids for ADCY9 Gene
- HGNC: 240
- Entrez Gene: 115
- Ensembl: ENSG00000162104
- OMIM: 603302
- UniProtKB: O60503
Previous GeneCards Identifiers for ADCY9 Gene
- GC16M004044
- GC16M004015
- GC16M003952
- GC16M004003
Summaries for ADCY9 Gene
-
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADCY9 Gene
ADCY9 (Adenylate Cyclase 9) is a Protein Coding gene. Diseases associated with ADCY9 include Rubinstein-Taybi Syndrome and Malaria. Among its related pathways are Signaling in Gap Junctions and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY8.
UniProtKB/Swiss-Prot for ADCY9 Gene
-
Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).
-
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY9 Gene
Genomics for ADCY9 Gene
Regulatory Elements for ADCY9 Gene
Enhancers for ADCY9 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ADCY9 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ADCY9 gene promoter:
Regulatory Element Products
Genomic Location for ADCY9 Gene
- Chromosome:
- 16
- Start:
- 3,953,387 bp from pter
- End:
- 4,116,185 bp from pter
- Size:
- 162,799 bases
- Orientation:
- Minus strand
Genomic View for ADCY9 Gene
Genes around ADCY9 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p13.3 by Ensembl
- 16p13.3 by Entrez Gene
- 16p13.3 by HGNC
ADCY9 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADCY9 Gene
Proteins for ADCY9 Gene
-
Protein details for ADCY9 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60503-ADCY9_HUMAN
- Recommended name:
- Adenylate cyclase type 9
- Protein Accession:
- O60503
- A7E2V5
- A7E2X2
- D3DUD1
- O60273
- Q4ZHT9
- Q4ZIR5
- Q9BWT4
- Q9UGP2
Protein attributes for ADCY9 Gene
- Size:
- 1353 amino acids
- Molecular mass:
- 150701 Da
- Cofactor:
- Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC24201.1; Type=Frameshift; Positions=1252; Evidence={ECO:0000305}; Sequence=BAA25446.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for ADCY9 Gene
Selected DME Specific Peptides for ADCY9 Gene
- O60503:
-
- TYMAASGLN
- RRQKKLPQLFER
- ADIVGFT
- FLLLLLVWFLNR
- KMGYDFDYRGTVNVKGKGQMKTY
- ADQLKGLKT
- DHAYCCIEMGLGMI
- EKIKTIG
- ERCFPQTQRRFRYAL
- ISPDIRVQVDGSIGRSPTDEI
- DQSALLPLRFKNIREKTDAHFV
- GVIFASIVNFSEFYEENYEGGKECYR
- MRVGVHTGTVL
Post-translational modifications for ADCY9 Gene
Other Protein References for ADCY9 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ADCY9
- Novus Biologicals Antibodies for ADCY9
-
Cloud-Clone Corp. Antibodies for ADCY9
- Invitrogen Antibodies for ADCY9
- antibodies-online Antibodies for ADCY9: See all 53
- GeneTex ADCY9 antibody for ADCY9
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADCY9
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADCY9
- Origene Custom Protein Services for ADCY9
- Novus Biologicals proteins for ADCY9
-
Cloud-Clone Corp. Proteins for ADCY9
- antibodies-online Proteins for ADCY9: See all 2
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ADCY9
Domains & Families for ADCY9 Gene
Gene Families for ADCY9 Gene
- HGNC:
- IUPHAR :
Protein Domains for ADCY9 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ADCY9 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O60503UniProtKB/Swiss-Prot:
ADCY9_HUMAN :- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
- Domain:
-
- The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
- Family:
-
- Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Function for ADCY9 Gene
Molecular function for ADCY9 Gene
- GENATLAS Biochemistry:
- adenylyl cyclase type IX,ubiquitously,with highest levels in skeletal muscle,heart and brain
- UniProtKB/Swiss-Prot CatalyticActivity:
- ATP = 3,5-cyclic AMP + diphosphate.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation (PubMed:9628827). Activity is down-regulated by calcium/calcineurin (PubMed:10987815).
- UniProtKB/Swiss-Prot Function:
- Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors (PubMed:9628827, PubMed:12972952, PubMed:15879435, PubMed:10987815). Contributes to signaling cascades activated by CRH (corticotropin-releasing factor), corticosteroids and beta-adrenergic receptors (PubMed:9628827).
Enzyme Numbers (IUBMB) for ADCY9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004016 | adenylate cyclase activity | IDA,TAS | 9628827 |
| GO:0004383 | guanylate cyclase activity | IBA | -- |
| GO:0005524 | ATP binding | IEA | -- |
| GO:0016829 | lyase activity | IEA | -- |
| GO:0016849 | phosphorus-oxygen lyase activity | IEA | -- |
Phenotypes for ADCY9 Gene
- MGI mutant phenotypes for ADCY9:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for ADCY9:
Animal Models for ADCY9 Gene
- MGI Knock Outs for ADCY9:
-
- Adcy9 tm1b(EUCOMM)Wtsi
Animal Model Products
-
Taconic Biosciences Mouse Models for ADCY9
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADCY9
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADCY9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADCY9 gene
- Search ViGene Biosciences for ADCY9
CRISPR Products
-
OriGene CRISPR knockouts for ADCY9
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY9
- GenScript: Design CRISPR guide RNA sequences for ADCY9
miRNA for ADCY9 Gene
- miRTarBase miRNAs that target ADCY9
-
- hsa-mir-193b-3p (MIRT016333)
- hsa-mir-124-3p (MIRT022222)
- hsa-mir-7-5p (MIRT025695)
- hsa-mir-98-5p (MIRT027498)
- hsa-let-7d-5p (MIRT032153)
- hsa-mir-877-3p (MIRT037005)
- hsa-mir-744-5p (MIRT037595)
- hsa-mir-33b-5p (MIRT039580)
- hsa-mir-331-3p (MIRT043559)
- hsa-mir-10a-5p (MIRT047729)
- hsa-mir-99a-5p (MIRT048684)
- hsa-mir-181b-5p (MIRT054648)
- hsa-mir-143-5p (MIRT494822)
- hsa-mir-3944-5p (MIRT494823)
- hsa-mir-6870-5p (MIRT494824)
- hsa-mir-7111-5p (MIRT494825)
- hsa-mir-5698 (MIRT494826)
- hsa-mir-4723-5p (MIRT494827)
- hsa-mir-939-5p (MIRT494828)
- hsa-mir-1343-5p (MIRT494829)
- hsa-mir-6827-5p (MIRT494830)
- hsa-mir-3656 (MIRT494831)
- hsa-mir-6722-3p (MIRT494832)
- hsa-mir-1909-3p (MIRT494833)
- hsa-mir-6836-5p (MIRT494834)
- hsa-mir-6132 (MIRT494835)
- hsa-mir-6798-5p (MIRT494836)
- hsa-mir-1225-3p (MIRT494837)
- hsa-mir-6794-5p (MIRT494838)
- hsa-mir-4716-3p (MIRT494839)
- hsa-mir-3943 (MIRT494840)
- hsa-mir-1277-5p (MIRT512308)
- hsa-mir-190a-3p (MIRT512309)
- hsa-mir-3201 (MIRT512310)
- hsa-mir-4791 (MIRT512311)
- hsa-mir-8076 (MIRT512312)
- hsa-mir-1246 (MIRT512313)
- hsa-mir-5011-5p (MIRT512314)
- hsa-mir-410-3p (MIRT512315)
- hsa-mir-6516-5p (MIRT705887)
- hsa-mir-29b-2-5p (MIRT705888)
- hsa-mir-5047 (MIRT705889)
- hsa-mir-1301-3p (MIRT705890)
- hsa-mir-7156-3p (MIRT705891)
- hsa-mir-4436b-5p (MIRT705892)
- hsa-mir-185-3p (MIRT705893)
- hsa-mir-4656 (MIRT705894)
- hsa-mir-4448 (MIRT705895)
- hsa-mir-4660 (MIRT705896)
- hsa-mir-3177-3p (MIRT705897)
- hsa-mir-4508 (MIRT705898)
- hsa-mir-3189-3p (MIRT705899)
- hsa-mir-212-5p (MIRT705900)
- hsa-mir-6736-3p (MIRT705901)
miRNA Products
- Search ViGene Biosciences for ADCY9
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for ADCY9
- Browse OriGene Inhibitory RNA Products For ADCY9
-
ViGene Biosciences ready-to-package AAV shRNAs for ADCY9 gene
Clone Products
-
OriGene ORF clones in human for ADCY9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADCY9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ADCY9
-
ViGene Biosciences adenoviral particle packaged cDNA for ADCY9 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADCY9 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADCY9 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCY9 Gene
Localization for ADCY9 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADCY9 Gene
- Cell membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| cytosol | 4 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | -- |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0005887 | integral component of plasma membrane | TAS,IDA | 10987815 |
| GO:0008074 | guanylate cyclase complex, soluble | IBA | -- |
| GO:0016020 | membrane | IEA | -- |
Pathways & Interactions for ADCY9 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling |
.93
|
.01
|
| 2 | RET signaling |
.92
|
|
| 3 | Vascular smooth muscle contraction | ||
| 4 | Development Endothelin-1/EDNRA signaling | ||
| 5 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
Pathways by source for ADCY9 Gene
6 BioSystems pathways for ADCY9 Gene
44 Reactome pathways for ADCY9 Gene
2 PharmGKB pathways for ADCY9 Gene
43 KEGG pathways for ADCY9 Gene
12 GeneGo (Thomson Reuters) pathways for ADCY9 Gene
23 Qiagen pathways for ADCY9 Gene
Interacting Proteins for ADCY9 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003091 | renal water homeostasis | TAS | -- |
| GO:0006171 | cAMP biosynthetic process | IEA,IDA | 9628827 |
| GO:0006182 | cGMP biosynthetic process | IBA | -- |
| GO:0007165 | signal transduction | TAS | 9628827 |
| GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway | TAS | -- |
Drugs & Compounds for ADCY9 Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| pyrophosphate |
|
14000-31-8 |
|
(5) Tocris Compounds for ADCY9 Gene
| Compound | Action | Cas Number |
|---|---|---|
| KH 7 | Selective soluble adenylyl cyclase inhibitor | 330676-02-3 |
| NKH 477 | Water-soluble adenylyl cyclase activator | 138605-00-2 |
| PACAP 1-27 | Potent stimulator of adenylyl cyclase | 127317-03-7 |
| PACAP 1-38 | Potent stimulator of adenylyl cyclase | 137061-48-4 |
| SQ 22536 | Adenylyl cyclase inhibitor | 17318-31-9 |
Transcripts for ADCY9 Gene
mRNA/cDNA for ADCY9 Gene
- (3) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (103) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for ADCY9
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADCY9
- GenScript: Design CRISPR guide RNA sequences for ADCY9
miRNA Products
- Search ViGene Biosciences for ADCY9
Inhibitory RNA Products
- Origene shRNA, RNAi, and siRNA products in human, mouse, rat for ADCY9
- Browse OriGene Inhibitory RNA Products For ADCY9
-
ViGene Biosciences ready-to-package AAV shRNAs for ADCY9 gene
Clone Products
-
OriGene ORF clones in human for ADCY9
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for ADCY9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY9
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - |
Expression for ADCY9 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Bone (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Cartilage (Muscoskeletal System)
- Chondrocytes Zeugopod Epiphyseal End
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Skeletal Muscle (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for ADCY9 Gene
This gene is overexpressed in Muscle - Skeletal (x5.8).
This gene is overexpressed in Frontal cortex (23.6), Testis (15.6), Fetal Brain (11.1), Placenta (7.4), and Pancreas (6.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADCY9 Gene
NURSA nuclear receptor signaling pathways regulating expression of ADCY9 Gene:
ADCY9SOURCE GeneReport for Unigene cluster for ADCY9 Gene:
Hs.391860mRNA Expression by UniProt/SwissProt for ADCY9 Gene:
O60503-ADCY9_HUMAN
Tissue specificity:
Detected in skeletal muscle, pancreas, lung, heart, kidney, liver, brain and placenta (PubMed:9628827, PubMed:10987815). Expressed in multiple cells of the lung, with expression highest in airway smooth muscle (PubMed:12972952).
Evidence on tissue expression from TISSUES for ADCY9 Gene
- Liver(4.3)
- Nervous system(4.3)
- Heart(4.2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for ADCY9
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY9 Gene
Orthologs for ADCY9 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADCY9 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adcy9 34 |
|
||
| cow (Bos Taurus) |
Mammalia | ADCY9 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ADCY9 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Adcy9 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ADCY9 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADCY9 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADCY9 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADCY9 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adcy9 34 |
|
||
| Str.3341 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | adcy9 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100333702 34 |
|
||
| adcy9 35 |
|
OneToMany | |||
| ADCY9 (2 of 2) 35 |
|
OneToMany | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000090 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Ac13E 36 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | acy-1 36 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.6556 34 |
|
- Species where no ortholog for ADCY9 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADCY9 Gene
(2) SIMAP similar genes for ADCY9 Gene using alignment to 6 proteins:
Variants for ADCY9 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000020630 | -- | 3,964,916(+) | CGGAT(A/G)TTTAT | intron-variant, utr-variant-3-prime | |
| rs1000022344 | -- | 4,110,482(+) | CCTCC(C/T)GGGTT | intron-variant | |
| rs1000037244 | -- | 4,012,293(+) | AGGTA(A/T)GGCAG | intron-variant | |
| rs1000041583 | -- | 4,010,177(+) | CCCTG(G/T)GAGCA | intron-variant | |
| rs1000054856 | -- | 4,110,171(+) | CAGAC(A/G)CGCCC | intron-variant |
Residual Variation Intolerance Score:
2.01% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.06;
68.80% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ADCY9 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY9 Gene
Disorders for ADCY9 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rubinstein-taybi syndrome |
|
|
| malaria |
|
|
Search ADCY9 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for ADCY9
No data available for UniProtKB/Swiss-Prot and Genatlas for ADCY9 Gene
Publications for ADCY9 Gene
- Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). (PMID: 9628827) Hacker B.M. … Storm D.R. (Genomics 1998) 2 3 4 22 64
- Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment. (PMID: 20175803) Ye Y.M. … Park H.S. (J Clin Pharm Ther 2009) 3 22 46 64
- Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. (PMID: 15879435) Tantisira K.G. … Liggett S.B. (Hum. Mol. Genet. 2005) 3 4 22 64
- An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. (PMID: 12972952) Small K.M. … Liggett S.B. (Pharmacogenetics 2003) 3 4 22 64
- Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. (PMID: 11840511) Toyota T. … Yoshikawa T. (Am. J. Med. Genet. 2002) 3 22 46 64
Products for ADCY9 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
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- Custom Antibody ServicesOriGene Antibodies for ADCY9
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ADCY9
- Origene Custom Protein Services for ADCY9
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ADCY9
- Browse OriGene Inhibitory RNA Products For ADCY9
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- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For ADCY9
- GenScript: Next-day shipping cDNA ORF clone for ADCY9 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for ADCY9
- GenScript Custom Assay Services for ADCY9
- GenScript Custom overexpressing Cell Line Services for ADCY9
- GenScript: Design CRISPR guide RNA sequences for ADCY9
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for ADCY9
- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for ADCY9
- Novus Biologicals proteins for ADCY9
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for ADCY9
- Cloud-Clone Corp. Proteins for ADCY9
- Cloud-Clone Corp Assay Kits for ADCY9
- Taconic Biosciences Mouse Models for ADCY9
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for ADCY9: See all 53
- antibodies-online Kits for ADCY9: See all 15
- antibodies-online Proteins for ADCY9: See all 2
- Search antibodies-online for peptides
- GeneTex ADCY9 antibody for ADCY9
- Search GeneTex for Proteins for ADCY9
- ViGene Biosciences adenoviral particle packaged cDNA for ADCY9 gene
- ViGene Biosciences lentiviral particle packaged cDNA for ADCY9 gene
- ViGene Biosciences ready-to-package AAV shRNAs for ADCY9 gene
- Search ViGene Biosciences for ADCY9
- Santa Cruz Biotechnology (SCBT) Antibodies for ADCY9
- Search Santa Cruz Biotechnology (SCBT) for ADCY9 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for ADCY9
- Horizon Cell Lines for ADCY9
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADCY9
- VectorBuilder custom plasmid, inducible vectors for ADCY9
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADCY9
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ADCY9 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
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- (21) IntAct
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- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
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- (128) Genetics Home Reference
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- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
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- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer