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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCY9 Gene

protein-coding   GIFtS: 66
GCID: GC16M004003

Adenylate Cyclase 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenylate Cyclase 91 2     AC92
Adenylate Cyclase Type IX2 3     Adenylate Cyclase Type 92
Adenylyl Cyclase 92 3     Type IX ATP Pyrophosphate-Lyase2
ATP Pyrophosphate-Lyase 92 3     KIAA05203
EC 4.6.1.13 8     

External Ids:    HGNC: 2401   Entrez Gene: 1152   Ensembl: ENSG000001621047   OMIM: 6033025   UniProtKB: O605033   

Export aliases for ADCY9 gene to outside databases

Previous GC identifers: GC16M004044 GC16M004015 GC16M003952


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCY9 Gene:
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated
by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely
distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to
forskolin, calcium, and somatostatin. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADCY9 Gene: 
ADCY9 (adenylate cyclase 9) is a protein-coding gene. Diseases associated with ADCY9 include precocious puberty, and rubinstein-taybi syndrome, and among its related super-pathways are PKA activation in glucagon signalling and DAG and IP3 signaling. GO annotations related to this gene include adenylate cyclase activity and metal ion binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503
Function: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP
determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)

summary for ADCY9 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010393.16  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCY9 gene promoter:
         Nkx6-1   GCNF-1   GCNF   c-Myb   CUTL1   GCNF-2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADCY9 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCY9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ADCY9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY9 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004003:  view genomic region     (about GC identifiers)

Start:
4,003,388 bp from pter      End:
4,166,186 bp from pter
Size:
162,799 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503 (See protein sequence)
Recommended Name: Adenylate cyclase type 9  
Size: 1353 amino acids; 150701 Da
Cofactor: Binds 2 magnesium ions per subunit
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=AAC24201.1; Type=Frameshift; Positions=1252; Sequence=BAA25446.3; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E2V5 D3DUD1 O60273 Q4ZHT9 Q4ZIR5 Q9BWT4 Q9UGP2

Explore the universe of human proteins at neXtProt for ADCY9: NX_O60503

Explore proteomics data for ADCY9 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O60503

  • 4/13 DME Specific Peptides for ADCY9 (O60503) (see all 13)
     ADIVGFT  EKIKTIG  ADQLKGLKT  TYMAASGLN 

    ADCY9 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADCY9 Protein Expression
    REFSEQ proteins: NP_001107.2  
    ENSEMBL proteins: 
     ENSP00000460066   ENSP00000294016   ENSP00000460160   ENSP00000461825  
    Reactome Protein details: O60503
    Human Recombinant Protein Products for ADCY9: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Custom MassSpec 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY9 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS9628827

    ADCY9 for ontologies           About GeneDecksing



    ADCY9 Antibody Products: 
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    Abcam antibodies for ADCY9
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    LSBio Antibodies in human, mouse, rat for ADCY9 

    Assay Products for ADCY9: 
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    Cloud-Clone Corp. ELISAs for ADCY9 
    Cloud-Clone Corp. CLIAs for ADCY9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC9 
    Adenylyl cyclases

    2 InterPro protein domains:
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry O60503

    ProtoNet protein and cluster: O60503

    UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY9_HUMAN, O60503
    Function: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP
    determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic
    receptor activation

         Genatlas biochemistry entry for ADCY9:
    adenylyl cyclase type IX,ubiquitously,with highest levels in skeletal muscle,heart and brain

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004016adenylate cyclase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016849phosphorus-oxygen lyase activity ----
    GO:0046872metal ion binding IEA--
         
    ADCY9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADCY9:
     Synthetic lethal with cisplati 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adcy9):
     immune system 

    ADCY9 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADCY9 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADCY9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY9 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY9 

    miRNA
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    8/66 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY9 (see all 66):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-640 hsa-miR-3074-3p hsa-miR-10b* hsa-miR-200b hsa-miR-376c hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY9

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of ADCY9

    Clone
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    GenScript: all cDNA clones in your preferred vector: ADCY9 (NM_001116)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY9
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY9


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADCY9 About   (see all 56)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PKA activation in glucagon signalling
    PKA activation in glucagon signalling0.94
    Neurophysiological process PGE2-induced pain processing0.44
    PKA-mediated phosphorylation of CREB0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.38
    PKA activation0.94
    Development Role of Activin A in cell differentiation and proliferation0.33
    Regulation of CFTR gating (normal and CF)0.80
    Development Beta-adrenergic receptors signaling via cAMP0.32
    2Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.91
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.65
    PLC-gamma1 signalling0.94
    G-protein mediated events0.64
    Ca-dependent events0.93
    Phospholipase C-mediated cascade0.57
    3Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    4Adenylate cyclase activating pathway
    Adenylate cyclase activating pathway0.71
    Inhibition of adenylate cyclase pathway0.71
    Adenylate cyclase inhibitory pathway0.71
    LPA4-mediated signaling events0.67
    5Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    Estrogen signaling pathway0.34
    GnRH signaling pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for ADCY9 (see all 9)
        Adenylate cyclase-activating neuropeptides
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling

    5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY9 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    5/12 GeneGo (Thomson Reuters) Pathways for ADCY9 (see all 12)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    5/6 BioSystems Pathways for ADCY9 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events
    LPA4-mediated signaling events

    5/50        Reactome Pathways for ADCY9 (see all 50)
        PKA activation
    Signaling by EGFR in Cancer
    G alpha (z) signalling events
    Downstream signal transduction
    Signal Transduction

    2 PharmGKB Pathways for ADCY9
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    5/28         Kegg Pathways  (Kegg details for ADCY9) (see all 28):
        Purine metabolism
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Vascular smooth muscle contraction


    ADCY9 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/297 Interacting proteins for ADCY9 (ENSP000002940164) via UniProtKB, MINT, STRING, and/or I2D (see all 297)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process ----
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    ADCY9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADCY9 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADCY9:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADCY9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    10/11 HMDB Compounds for ADCY9 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    5 Novoseek inferred chemical compound relationships for ADCY9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 58.3 4 9463474 (2), 11226046 (1)
    cyclic amp 50.9 2 11226046 (1), 17551263 (1)
    adenylate 48 5 11840511 (3), 15794946 (1), 20175803 (1)
    cyclosporin a 30.9 2 9822726 (1)
    calcium 20 5 9822726 (1), 15794946 (1)

    Search CenterWatch for drugs/clinical trials and news about ADCY9

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADCY9 gene: 
    NM_001116.3  

    Unigene Cluster for ADCY9:

    Adenylate cyclase 9
    Hs.391860  [show with all ESTs]
    Unigene Representative Sequence: NM_001116
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576936 ENST00000294016(uc002cvx.3) ENST00000574721 ENST00000575550
    ENST00000571467 ENST00000571889 ENST00000572288
    miRNA
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    GenScript: all cDNA clones in your preferred vector: ADCY9 (NM_001116)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY9
    Sirion Biotech Customized lentivirus for stable overexpression of ADCY9 
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY9
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCY9
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY9
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY9

    Additional mRNA sequence: 

    AB011092.3 AF036927.1 AJ133123.1 BC068612.1 BC136657.1 BC136658.1 BC151207.1 BC151229.1 
    DQ005545.1 DQ008441.1 

    5 DOTS entries:

    DT.455680  DT.97805016  DT.75141941  DT.95266612  DT.86849976 

    24/103 AceView cDNA sequences (see all 103):

    BF475884 NM_001116 BP350940 BF109524 AW470671 T08314 AI583402 BQ424543 
    AU141090 BM797762 AI572195 Z40718 BE504143 CA772679 BM981110 CB995114 
    AI659745 AW451539 CB959938 BC068612 AI052156 AW419172 AI656244 CD369407 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY9 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -     -                 -                                                               
    SP2:                                                        -     -     -     -                                             
    SP3:                                -     -                 -                                                               
    SP4:                                      -                 -     -                                                         
    SP5:                                -     -                                                                                 


    ECgene alternative splicing isoforms for ADCY9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCY9 expression in normal human tissues (normalized intensities)      ADCY9 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADCY9 Expression
    About this image


    ADCY9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/14 selected tissues (see all 14) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Limb Muscle Progenitor Cells Forelimb Myotome
             limb/hindlimb   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Spinal Cord (Nervous System)
             spinal/ganglion/dorsal root ganglion   
     
     Gut Tube (Gastrointestinal Tract)
             Foregut

    See ADCY9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCY9

    SOURCE GeneReport for Unigene cluster: Hs.391860

    UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503
    Tissue specificity: Expressed in multiple cells of the lung, with expression highest in airway smooth muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADCY9 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy91 , 5 adenylate cyclase 91, 5 86.77(n)1
    92.17(a)1
      16 (2.42 cM)5
    115151  NM_009624.21  NP_033754.21 
     42875295 
    chicken
    (Gallus gallus)
    Aves ADCY91 adenylate cyclase 9 77.64(n)
    82.03(a)
      395339  NM_204630.1  NP_989961.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY96
    Uncharacterized protein
    70(a)
    1 ↔ 1
    GL343856.1(90771-105256)
    African clawed frog
    (Xenopus laevis)
    Amphibia adcy92 adenylate cyclase 9 75.3(n)    Z46958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003337021 adenylate cyclase type 9-like 64.99(n)
    65.7(a)
      100333702  XM_003201097.1  XP_003201145.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ac13E1 , 3 adenylate cyclase3
    Adenylyl cyclase 35C1
    41(a)3
    53.19(n)1
    43.89(a)1
      324851  NM_001014745.11  NP_001014745.11 
    worm
    (Caenorhabditis elegans)
    Secernentea acy-11 , 3 adenylate cyclase3
    Protein ACY-11
    44(a)3
    49.52(n)1
    44.02(a)1
      III(4794001-4802353)3
    1756221  NM_065569.21  NP_497970.11 


    ENSEMBL Gene Tree for ADCY9 (if available)
    TreeFam Gene Tree for ADCY9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCY9 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  GUCY2F2  ADCY82  GUCY1A22  
    ADCY72  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    3 SIMAP similar genes for ADCY9 using alignment to 6 protein entries:     ADCY9_HUMAN (see all proteins):
    ADCY7    ADCY4    ADCY3

    ADCY9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4255 SNPs in ADCY9 are shown (see all 4255)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890937381,2
    --4012263(+) TACCTA/GCAATC 1 -- ds50010--------
    rs620369421,2
    C,F--4012480(+) TAACAT/CAAACA 1 -- ds50012Minor allele frequency- C:0.20NA EA 240
    rs1400247011,2
    C--4012508(+) TTGCC-/CTGTTTC 1 -- ds50010--------
    rs118611931,2
    C,F,H--4012524(+) GTCATG/CACGTG 1 -- ds50012Minor allele frequency- C:0.03NA WA 124
    rs1811677371,2
    --4012527(+) ATGACA/GTGAAA 1 -- ds50010--------
    rs1849571681,2
    --4012565(+) CAGATC/TGCAGA 1 -- ds50010--------
    rs1393804541,2
    --4012587(+) GTCCAA/GGGAAG 1 -- ds50010--------
    rs1500084701,2
    C--4012794(+) AGATTA/CTAGGC 1 -- ut310--------
    rs563977311,2
    C--4012825(+) ACCAAT/CTAAAA 1 -- ut312Minor allele frequency- C:0.12WA 120
    rs1465778861,2
    --4013013(+) GAGCCC/TGTGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADCY9 (4003388 - 4166186 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for ADCY9 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2750423CNV Deletion23290073
    esv2672506CNV Deletion23128226
    esv2658820CNV Deletion23128226
    esv2750422CNV Deletion23290073
    nsv509593CNV Insertion20534489
    nsv1718CNV Insertion18451855
    nsv526024CNV Loss19592680
    nsv510410CNV Loss20534489
    dgv2584n71CNV Loss21882294
    nsv517942CNV Loss19592680


    Human Gene Mutation Database (HGMD): ADCY9
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603302    OMIM disorders: --

    16 diseases for ADCY9:    About MalaCards
    precocious puberty    rubinstein-taybi syndrome    thyroid adenoma    adenoma
    chondrodysplasia    thyroiditis    mood disorder    cholera
    malaria    bipolar disorder    dilated cardiomyopathy    asthma
    neuronitis    colorectal cancer    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ADCY9:
    Cholera

    ADCY9 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ADCY9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 29.2 1 15879435 (1)

    Genetic Association Database (GAD): ADCY9
    Human Genome Epidemiology (HuGE) Navigator: ADCY9 (7 documents)

    Export disorders for ADCY9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCY9 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with ADCY9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). (PubMed id 9628827)1, 2, 3, 9 Hacker B.M.... Storm D.R. (1998)
    2. Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. (PubMed id 11840511)1, 4, 9 Toyota T....Yoshikawa T. (2002)
    3. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. (PubMed id 15879435)1, 2, 9 Tantisira K.G.... Liggett S.B. (2005)
    4. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. (PubMed id 12972952)1, 2, 9 Small K.M....Liggett S.B. (2003)
    5. Pharmacogenetic study of the effects of NK2R G231E G& gt;A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled cortico steroid treatment. (PubMed id 20175803)1, 4, 9 Ye Y.M....Park H.S. (2009)
    6. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (2010)
    7. Common genetic variation and susceptibility to partia l epilepsies: a genome-wide association study. (PubMed id 20522523)1, 4 KasperaviciAte D....Sisodiya S.M. (2010)
    8. Candidate malaria susceptibility/protective SNPs in h ospital and population-based studies: the effect of sub-structuring. (PubMed id 20459687)1, 4 Eid N.A....Ibrahim M.E. (2010)
    9. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    10. Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder. (PubMed id 12082561)1, 4 Toyota T....Yoshikawa T. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115 HGNC: 240 AceView: ADCY9 Ensembl:ENSG00000162104 euGenes: HUgn115
    ECgene: ADCY9 Kegg: 115 H-InvDB: ADCY9

    (According to HUGE)
    About This Section
    HUGE: KIAA0520

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCY9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADCY9 gene:
    Search GeneIP for patents involving ADCY9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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