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ADCY9 Gene

protein-coding   GIFtS: 68
GCID: GC16M004003

Adenylate Cyclase 9

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase 91 2     AC92
Adenylate Cyclase Type IX2 3     Adenylate Cyclase Type 92
Adenylyl Cyclase 92 3     Type IX ATP Pyrophosphate-Lyase2
ATP Pyrophosphate-Lyase 92 3     KIAA05203
EC 4.6.1.13 8     

External Ids:    HGNC: 2401   Entrez Gene: 1152   Ensembl: ENSG000001621047   OMIM: 6033025   UniProtKB: O605033   

Export aliases for ADCY9 gene to outside databases

Previous GC identifers: GC16M004044 GC16M004015 GC16M003952


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCY9 Gene:
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated
by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely
distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to
forskolin, calcium, and somatostatin. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADCY9 Gene:
ADCY9 (adenylate cyclase 9) is a protein-coding gene. Diseases associated with ADCY9 include precocious puberty, and thyroid adenoma. GO annotations related to this gene include adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503
Function: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP
determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)

summary for ADCY9 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010393.17  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCY9 gene promoter:
         Nkx6-1   GCNF-1   GCNF   c-Myb   CUTL1   GCNF-2   HNF-4alpha1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADCY9 promoter sequence
   Search Chromatin IP Primers for ADCY9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCY9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ADCY9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY9 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M004003:  view genomic region     (about GC identifiers)

Start:
4,003,388 bp from pter      End:
4,166,186 bp from pter
Size:
162,799 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503 (See protein sequence)
Recommended Name: Adenylate cyclase type 9  
Size: 1353 amino acids; 150701 Da
Cofactor: Binds 2 magnesium ions per subunit
Sequence caution: Sequence=AAC24201.1; Type=Frameshift; Positions=1252; Sequence=BAA25446.3; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: A7E2V5 D3DUD1 O60273 Q4ZHT9 Q4ZIR5 Q9BWT4 Q9UGP2

Explore the universe of human proteins at neXtProt for ADCY9: NX_O60503

Explore proteomics data for ADCY9 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys622, Lys1218
  • Glycosylation2 at Asn206, Asn955, Asn964
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADCY9 (O60503) (see all 13)
     ADIVGFT  EKIKTIG  ADQLKGLKT  TYMAASGLN 


    See ADCY9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001107.2  
    ENSEMBL proteins: 
     ENSP00000460066   ENSP00000294016   ENSP00000460160   ENSP00000461825  
    Reactome Protein details: O60503

    ADCY9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ADCY9

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    Abcam antibodies for ADCY9
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    LSBio Antibodies in human, mouse, rat for ADCY9

    ADCY9 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for ADCY9
    Cloud-Clone Corp. CLIAs for ADCY9


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC9
    Adenylyl cyclases

    2 InterPro protein domains:
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry O60503

    ProtoNet protein and cluster: O60503

    UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY9 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY9_HUMAN, O60503
    Function: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP
    determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic
    receptor activation

         Genatlas biochemistry entry for ADCY9:
    adenylyl cyclase type IX,ubiquitously,with highest levels in skeletal muscle,heart and brain

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004016adenylate cyclase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016849phosphorus-oxygen lyase activity ----
    GO:0046872metal ion binding IEA--
         
    ADCY9 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADCY9:
     Synthetic lethal with cisplati 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adcy9):
     hematopoietic system  immune system 

    ADCY9 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADCY9
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADCY9

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY9
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY9

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADCY9:
    hsa-mir-33b-5p (MIRT039580), hsa-mir-877-3p (MIRT037005), hsa-mir-193b-3p (MIRT016333), hsa-mir-124-3p (MIRT022222), hsa-mir-331-3p (MIRT043559), hsa-let-7d-5p (MIRT032153), hsa-mir-98-5p (MIRT027498), hsa-mir-744-5p (MIRT037595), hsa-mir-7-5p (MIRT025695), hsa-mir-99a-5p (MIRT048684), hsa-mir-10a-5p (MIRT047729)

    Block miRNA regulation of human, mouse, rat ADCY9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADCY9 (see all 66):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-640 hsa-miR-3074-3p hsa-miR-10b* hsa-miR-200b hsa-miR-376c hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADCY9

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ADCY9 (see all 6)
    OriGene ORF clones in mouse, rat for ADCY9
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY9 (NM_001116)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY9

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ADCY9 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY9


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADCY9_HUMAN, O60503: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9628827
    GO:0030424axon IEA--
    GO:0030425dendrite IEA--

    ADCY9 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCY9 About   (see all 57)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Adenylate cyclase inhibitory pathway
    Adenylate cyclase inhibitory pathway0.53
    Inhibition of adenylate cyclase pathway0.00
    LPA4-mediated signaling events0.53
    Adenylate cyclase activating pathway0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADCY9 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ADCY9 (see all 12)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    Selected BioSystems Pathways for ADCY9 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events
    Endothelins

    Selected Reactome Pathways for ADCY9 (see all 9)
        PKA activation
    PKA activation in glucagon signalling
    G alpha (z) signalling events
    Adenylate cyclase inhibitory pathway
    Glucagon signaling in metabolic regulation

    2 PharmGKB Pathways for ADCY9
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADCY9) (see all 32):
        Purine metabolism
    Rap1 signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis


    ADCY9 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADCY9
    Interactions:

        Search GeneGlobe Interaction Network for ADCY9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCY9 (ENSP000002940164) via UniProtKB, MINT, STRING, and/or I2D (see all 305)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process ----
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    ADCY9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADCY9 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    Selected HMDB Compounds for ADCY9 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    5 Novoseek inferred chemical compound relationships for ADCY9 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 58.3 4 9463474 (2), 11226046 (1)
    cyclic amp 50.9 2 11226046 (1), 17551263 (1)
    adenylate 48 5 11840511 (3), 15794946 (1), 20175803 (1)
    cyclosporin a 30.9 2 9822726 (1)
    calcium 20 5 9822726 (1), 15794946 (1)



    ADCY9 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADCY9 gene: 
    NM_001116.3  

    Unigene Cluster for ADCY9:

    Adenylate cyclase 9
    Hs.391860  [show with all ESTs]
    Unigene Representative Sequence: NM_001116
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000576936 ENST00000294016(uc002cvx.3) ENST00000574721 ENST00000575550
    ENST00000571467 ENST00000571889 ENST00000572288
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADCY9 (see all 66):
    hsa-miR-607 hsa-miR-193a-3p hsa-miR-640 hsa-miR-3074-3p hsa-miR-10b* hsa-miR-200b hsa-miR-376c hsa-miR-4273
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY9 (NM_001116)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY9
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY9
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY9
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADCY9
      QuantiTect SYBR Green Assays in human, mouse, rat ADCY9
      QuantiFast Probe-based Assays in human, mouse, rat ADCY9

    Additional mRNA sequence: 

    AB011092.3 AF036927.1 AJ133123.1 BC068612.1 BC136657.1 BC136658.1 BC151207.1 BC151229.1 
    DQ005545.1 DQ008441.1 

    5 DOTS entries:

    DT.455680  DT.97805016  DT.75141941  DT.95266612  DT.86849976 

    Selected AceView cDNA sequences (see all 103):

    AU141090 AI583402 BF109524 BM797762 Z40718 T08314 AI572195 BE504143 
    AW470671 CA772679 NM_001116 BP350940 BQ424543 BF475884 AW419172 BE926508 
    CB959938 BC068612 BX491245 AK022108 BE858662 BM453519 AW451539 AI052156 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADCY9 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                                -     -                 -                                                               
    SP2:                                                        -     -     -     -                                             
    SP3:                                -     -                 -                                                               
    SP4:                                      -                 -     -                                                         
    SP5:                                -     -                                                                                 


    ECgene alternative splicing isoforms for ADCY9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADCY9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADCY9 Expression
    About this image


    ADCY9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Limb (Muscoskeletal System)
             Limb Muscle Progenitor Cells Forelimb Myotome
    ADCY9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCY9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.391860

    UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503
    Tissue specificity: Expressed in multiple cells of the lung, with expression highest in airway smooth muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADCY9 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy91 , 5 adenylate cyclase 91, 5 86.77(n)1
    92.17(a)1
      16 (2.42 cM)5
    115151  NM_009624.21  NP_033754.21 
     42875295 
    chicken
    (Gallus gallus)
    Aves ADCY91 adenylate cyclase 9 77.34(n)
    81.35(a)
      395339  NM_204630.1  NP_989961.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY96
    adenylate cyclase 9
    71(a)
    1 ↔ 1
    GL343856.1(90771-105256)
    African clawed frog
    (Xenopus laevis)
    Amphibia adcy92 adenylate cyclase 9 75.3(n)    Z46958.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003337021 adenylate cyclase type 9-like 64.69(n)
    65.21(a)
      100333702  XM_003201097.2  XP_003201145.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ac13E1 , 3 adenylate cyclase3
    Adenylyl cyclase 35C1
    41(a)3
    53.03(n)1
    43.96(a)1
      324851  NM_001014745.21  NP_001014745.11 
    worm
    (Caenorhabditis elegans)
    Secernentea acy-11 , 3 adenylate cyclase3
    acy-11
    44(a)3
    52.28(n)1
    48.46(a)1
      III(4794001-4802353)3
    1756221  NM_065569.31  NP_497970.11 


    ENSEMBL Gene Tree for ADCY9 (if available)
    TreeFam Gene Tree for ADCY9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADCY9 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY72  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    2 SIMAP similar genes for ADCY9 using alignment to 6 protein entries:     ADCY9_HUMAN (see all proteins):
    ADCY7    ADCY4

    ADCY9 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADCY9 (see all 4255)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890937381,2
    --4012263(+) TACCTA/GCAATC 1 -- ds50010--------
    rs620369421,2
    C,F--4012480(+) TAACAT/CAAACA 1 -- ds50012Minor allele frequency- C:0.20NA EA 240
    rs1400247011,2
    C--4012508(+) TTGCC-/CTGTTTC 1 -- ds50010--------
    rs118611931,2
    C,F,H--4012524(+) GTCATG/CACGTG 1 -- ds50012Minor allele frequency- C:0.03NA WA 124
    rs1811677371,2
    --4012527(+) ATGACA/GTGAAA 1 -- ds50010--------
    rs1849571681,2
    --4012565(+) CAGATC/TGCAGA 1 -- ds50010--------
    rs1393804541,2
    --4012587(+) GTCCAA/GGGAAG 1 -- ds50010--------
    rs1500084701,2
    C--4012794(+) AGATTA/CTAGGC 1 -- ut310--------
    rs563977311,2
    C--4012825(+) ACCAAT/CTAAAA 1 -- ut312Minor allele frequency- C:0.12WA 120
    rs1465778861,2
    --4013013(+) GAGCCC/TGTGGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADCY9 (4003388 - 4166186 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADCY9 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2750423CNV Deletion23290073
    esv2672506CNV Deletion23128226
    esv2658820CNV Deletion23128226
    esv2750422CNV Deletion23290073
    nsv509593CNV Insertion20534489
    nsv1718CNV Insertion18451855
    nsv526024CNV Loss19592680
    nsv510410CNV Loss20534489
    dgv2584n71CNV Loss21882294
    nsv517942CNV Loss19592680

    Human Gene Mutation Database (HGMD): ADCY9
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADCY9
    DNA2.0 Custom Variant and Variant Library Synthesis for ADCY9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603302    OMIM disorders: --

    19 diseases for ADCY9:    
    About MalaCards
    precocious puberty    thyroid adenoma    rubinstein-taybi syndrome    adenoma
    chondrodysplasia    thyroiditis    mood disorder    dilated cardiomyopathy
    cholera    malaria    asthma    bipolar disorder
    neuronitis    hypertension    colorectal cancer    pancreatitis
    hiv-1    breast cancer    cerebritis

    1 disease from the University of Copenhagen DISEASES database for ADCY9:
    Cholera

    ADCY9 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ADCY9 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    asthma 29.2 1 15879435 (1)

    Genetic Association Database (GAD): ADCY9
    Human Genome Epidemiology (HuGE) Navigator: ADCY9 (7 documents)

    Export disorders for ADCY9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADCY9 gene, integrated from 10 sources (see all 53):
    (articles sorted by number of sources associating them with ADCY9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). (PubMed id 9628827)1, 2, 3, 9 Hacker B.M.... Storm D.R. (Genomics 1998)
    2. Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. (PubMed id 11840511)1, 4, 9 Toyota T....Yoshikawa T. (Am. J. Med. Genet. 2002)
    3. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. (PubMed id 15879435)1, 2, 9 Tantisira K.G.... Liggett S.B. (Hum. Mol. Genet. 2005)
    4. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. (PubMed id 12972952)1, 2, 9 Small K.M....Liggett S.B. (Pharmacogenetics 2003)
    5. Pharmacogenetic study of the effects of NK2R G231E G&gt;A and TBX21 H33Q C&gt;G polymorphisms on asthma control with inhaled corticosteroid treatment. (PubMed id 20175803)1, 4, 9 Ye Y.M....Park H.S. (J Clin Pharm Ther 2009)
    6. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    7. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. (PubMed id 20522523)1, 4 KasperaviciAte D....Sisodiya S.M. (Brain 2010)
    8. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. (PubMed id 20459687)1, 4 Eid N.A....Ibrahim M.E. (Malar. J. 2010)
    9. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    10. Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder. (PubMed id 12082561)1, 4 Toyota T....Yoshikawa T. (Mol. Psychiatry 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115 HGNC: 240 AceView: ADCY9 Ensembl:ENSG00000162104 euGenes: HUgn115
    ECgene: ADCY9 Kegg: 115 H-InvDB: ADCY9

    (According to HUGE)
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    HUGE: KIAA0520

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADCY9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADCY9 gene:
    Search GeneIP for patents involving ADCY9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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