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Aliases for ADCY9 Gene

Aliases for ADCY9 Gene

  • Adenylate Cyclase 9 2 3
  • Adenylate Cyclase Type IX 3 4
  • ATP Pyrophosphate-Lyase 9 3 4
  • Adenylyl Cyclase 9 3 4
  • EC 4 63
  • Type IX ATP Pyrophosphate-Lyase 3
  • Adenylate Cyclase Type 9 3
  • KIAA0520 4
  • AC9 3

External Ids for ADCY9 Gene

Previous GeneCards Identifiers for ADCY9 Gene

  • GC16M004044
  • GC16M004015
  • GC16M003952
  • GC16M004003

Summaries for ADCY9 Gene

Entrez Gene Summary for ADCY9 Gene

  • Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY9 Gene

ADCY9 (Adenylate Cyclase 9) is a Protein Coding gene. Diseases associated with ADCY9 include rubinstein-taybi syndrome and thyroid adenoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY9 Gene

  • May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).

Tocris Summary for ADCY9 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY9 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY9 Gene

Genomics for ADCY9 Gene

Regulatory Elements for ADCY9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCY9 Gene

3,953,387 bp from pter
4,116,185 bp from pter
162,799 bases
Minus strand

Genomic View for ADCY9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY9 Gene

Proteins for ADCY9 Gene

  • Protein details for ADCY9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenylate cyclase type 9
    Protein Accession:
    Secondary Accessions:
    • A7E2V5
    • A7E2X2
    • D3DUD1
    • O60273
    • Q4ZHT9
    • Q4ZIR5
    • Q9BWT4
    • Q9UGP2

    Protein attributes for ADCY9 Gene

    1353 amino acids
    Molecular mass:
    150701 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    No Data Available
    • Sequence=AAC24201.1; Type=Frameshift; Positions=1252; Evidence={ECO:0000305}; Sequence=BAA25446.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ADCY9 Gene

Proteomics data for ADCY9 Gene at MOPED

Post-translational modifications for ADCY9 Gene

  • Ubiquitination at Lys622 and Lys1218
  • Glycosylation at Asn206, Asn955, and Asn964
  • Modification sites at PhosphoSitePlus

Other Protein References for ADCY9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADCY9 Gene

Gene Families for ADCY9 Gene

  • ADCY :Adenylate cyclases

Protein Domains for ADCY9 Gene

Suggested Antigen Peptide Sequences for ADCY9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • O60503
  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY9: view

Function for ADCY9 Gene

Molecular function for ADCY9 Gene

GENATLAS Biochemistry:
adenylyl cyclase type IX,ubiquitously,with highest levels in skeletal muscle,heart and brain
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic receptor activation
UniProtKB/Swiss-Prot Function:
May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity).

Enzyme Numbers (IUBMB) for ADCY9 Gene

Gene Ontology (GO) - Molecular Function for ADCY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016849 phosphorus-oxygen lyase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADCY9: view

Phenotypes for ADCY9 Gene

MGI mutant phenotypes for ADCY9:
inferred from 1 alleles
GenomeRNAi human phenotypes for ADCY9:
genes like me logo Genes that share phenotypes with ADCY9: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY9

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADCY9 Gene

Localization for ADCY9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY9 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADCY9 Gene COMPARTMENTS Subcellular localization image for ADCY9 gene
Compartment Confidence
plasma membrane 4
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADCY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9628827
genes like me logo Genes that share ontologies with ADCY9: view

Pathways for ADCY9 Gene

SuperPathways for ADCY9 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY9: view

Interacting Proteins for ADCY9 Gene

Gene Ontology (GO) - Biological Process for ADCY9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process IEA --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY9: view

Compounds for ADCY9 Gene

(5) Tocris Compounds for ADCY9 Gene

Compound Action Cas Number
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
PACAP 1-38 Potent stimulator of adenylyl cyclase [137061-48-4]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(11) HMDB Compounds for ADCY9 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • Ca
Cyclic AMP
  • Cyclic AMP
Cyclic GMP
  • 3',5'-cyclic GMP
Guanosine triphosphate
  • 5'-GTP

(5) Novoseek inferred chemical compound relationships for ADCY9 Gene

Compound -log(P) Hits PubMed IDs
forskolin 58.3 3
cyclic amp 50.9 2
adenylate 48 5
cyclosporin a 30.9 1
calcium 20 2
genes like me logo Genes that share compounds with ADCY9: view

Transcripts for ADCY9 Gene

Unigene Clusters for ADCY9 Gene

Adenylate cyclase 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY9 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: - - -

Relevant External Links for ADCY9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCY9 Gene

mRNA expression in normal human tissues for ADCY9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY9 Gene

This gene is overexpressed in Muscle - Skeletal (5.8).

Protein differential expression in normal tissues for ADCY9 Gene

This gene is overexpressed in Frontal cortex (23.6), Testis (15.6), Fetal Brain (11.1), Placenta (7.4), and Pancreas (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADCY9 Gene

SOURCE GeneReport for Unigene cluster for ADCY9 Gene Hs.391860

mRNA Expression by UniProt/SwissProt for ADCY9 Gene

Tissue specificity: Expressed in multiple cells of the lung, with expression highest in airway smooth muscle.
genes like me logo Genes that share expressions with ADCY9: view

Expression partners for ADCY9 Gene

In Situ Assay Products

Orthologs for ADCY9 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY9 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCY9 35
  • 88.65 (n)
  • 91.41 (a)
ADCY9 36
  • 91 (a)
(Canis familiaris)
Mammalia ADCY9 35
  • 88.61 (n)
  • 92.97 (a)
ADCY9 36
  • 92 (a)
(Mus musculus)
Mammalia Adcy9 35
  • 86.77 (n)
  • 92.17 (a)
Adcy9 16
Adcy9 36
  • 92 (a)
(Pan troglodytes)
Mammalia ADCY9 35
  • 99.32 (n)
  • 99.47 (a)
ADCY9 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Adcy9 35
  • 88.77 (n)
  • 94.86 (a)
(Monodelphis domestica)
Mammalia ADCY9 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia ADCY9 36
  • 84 (a)
(Gallus gallus)
Aves ADCY9 35
  • 77.34 (n)
  • 81.35 (a)
ADCY9 36
  • 83 (a)
(Anolis carolinensis)
Reptilia ADCY9 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy9 35
  • 66.8 (n)
  • 71 (a)
Str.3341 35
African clawed frog
(Xenopus laevis)
Amphibia adcy9 35
(Danio rerio)
Actinopterygii LOC100333702 35
  • 64.69 (n)
  • 65.21 (a)
adcy9 36
  • 61 (a)
ADCY9 (2 of 2) 36
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ac13E 37
  • 41 (a)
Ac13E 35
  • 53.03 (n)
  • 43.96 (a)
Ac13E 36
  • 28 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000090 35
  • 57.02 (n)
  • 46.84 (a)
(Caenorhabditis elegans)
Secernentea acy-1 37
  • 44 (a)
acy-1 35
  • 52.28 (n)
  • 48.46 (a)
acy-1 36
  • 34 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6556 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for ADCY9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY9 Gene

Gene Tree for ADCY9 (if available)
Gene Tree for ADCY9 (if available)

Paralogs for ADCY9 Gene

Selected SIMAP similar genes for ADCY9 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ADCY9: view

Variants for ADCY9 Gene

Sequence variations from dbSNP and Humsavar for ADCY9 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs11359 -- 3,963,555(-) CAAAG(G/T)GGAGT utr-variant-3-prime
rs365010 -- 4,102,189(+) AAATA(A/C)GTGCT intron-variant
rs370222 -- 4,107,695(+) GGAAG(A/G)AAGGG intron-variant
rs378024 -- 4,081,876(-) CGCCG(C/T)CCCCT intron-variant
rs378200 -- 4,093,180(+) ATTGA(C/T)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY9 Gene

Variant ID Type Subtype PubMed ID
nsv833130 CNV Gain 17160897
esv21490 CNV Gain+Loss 19812545
nsv905218 CNV Loss 21882294
nsv833131 CNV Loss 17160897
nsv905219 CNV Loss 21882294
dgv2584n71 CNV Loss 21882294
nsv510410 CNV Loss 20534489
nsv525374 CNV Gain 19592680
nsv1718 CNV Insertion 18451855
esv2658820 CNV Deletion 23128226
esv2750422 CNV Deletion 23290073
nsv517942 CNV Loss 19592680
nsv526024 CNV Loss 19592680
nsv509593 CNV Insertion 20534489
esv2750423 CNV Deletion 23290073
esv2672506 CNV Deletion 23128226
nsv1719 CNV Loss 18451855
nsv528573 CNV Loss 19592680
dgv458n67 CNV Gain 20364138

Relevant External Links for ADCY9 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY9 Gene

Disorders for ADCY9 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADCY9 Gene in MalaCards »

(4) Diseases for ADCY9 Gene including...

(1) University of Copenhagen DISEASES for ADCY9 Gene

(1) Novoseek inferred disease relationships for ADCY9 Gene

Disease -log(P) Hits PubMed IDs
asthma 29.2 1

Relevant External Links for ADCY9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADCY9: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for ADCY9 Gene

Publications for ADCY9 Gene

  1. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). (PMID: 9628827) Hacker B.M. … Storm D.R. (Genomics 1998) 2 3 4 23
  2. Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. (PMID: 11840511) Toyota T. … Yoshikawa T. (Am. J. Med. Genet. 2002) 3 23 48
  3. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. (PMID: 12972952) Small K.M. … Liggett S.B. (Pharmacogenetics 2003) 3 4 23
  4. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. (PMID: 15879435) Tantisira K.G. … Liggett S.B. (Hum. Mol. Genet. 2005) 3 4 23
  5. Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment. (PMID: 20175803) Ye Y.M. … Park H.S. (J Clin Pharm Ther 2009) 3 23 48

Products for ADCY9 Gene

Sources for ADCY9 Gene

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