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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADCY9 Gene

protein-coding GIFtS: 65
GCID: GC16M004003

adenylate cyclase 9

Explore 16 diseases affiliated with
ADCY9 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenylate Cyclase 9¹ ²		EC 4.6.1.1³ ⁸
AC9¹ ²		Adenylate Cyclase Type 9²
Adenylate Cyclase Type IX² ³		Type IX ATP Pyrophosphate-Lyase²
Adenylyl Cyclase 9² ³		KIAA0520³
ATP Pyrophosphate-Lyase 9² ³

External Ids:	HGNC: 240¹	Entrez Gene: 115²	Ensembl: ENSG00000162104⁷	OMIM: 603302⁵	UniProtKB: O60503³

Export aliases for ADCY9 gene to outside databases

Previous GC identifers: GC16M004044 GC16M004015 GC16M003952

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCY9:

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a

family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely

distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to

forskolin, calcium, and somatostatin. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503

Function: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP

determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)

summary for ADCY9:

Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into

3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;

nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and

muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase

isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8

are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are

distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive

and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,

phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this

enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid

addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and

chondrodysplasia.

Gene Wiki entry for ADCY9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADCY9 gene promoter:
Nkx6-1 GCNF-1 GCNF c-Myb CUTL1 GCNF-2 HNF-4alpha1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADCY9 promoter sequence

Search SABiosciences Chromatin IP Primers for ADCY9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3

ADCY9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY9 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16M004003: view genomic region (about GC identifiers)

Start:	4,003,388 bp from pter	End:	4,166,186 bp from pter
Size:	162,799 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503 (See protein sequence)

Recommended Name: Adenylate cyclase type 9

Size: 1353 amino acids; 150701 Da

Cofactor: Binds 2 magnesium ions per subunit

Subcellular location: Membrane; Multi-pass membrane protein

Sequence caution: Sequence=AAC24201.1; Type=Frameshift; Positions=1252; Sequence=BAA25446.3; Type=Erroneous initiation;

Note=Translation N-terminally shortened;

Secondary accessions: A7E2V5 D3DUD1 O60273 Q4ZHT9 Q4ZIR5 Q9BWT4 Q9UGP2

Explore the universe of human proteins at neXtProt for ADCY9: NX_O60503

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60503

4/13 DME Specific Peptides for ADCY9 (O60503) (see all 13)

ADIVGFT

EKIKTIG

ADQLKGLKT

TYMAASGLN

ADCY9 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001107.2

ENSEMBL proteins:

ENSP00000460066 ENSP00000294016 ENSP00000460160 ENSP00000461825

Reactome Protein details: O60503
Human Recombinant Protein Products:

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	Uscn Proteins for ADCY9

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9628827

ADCY9 for ontologies About GeneDecksing

ADCY9 Antibody Products:

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	Uscn ELISAs and CLIAs for ADCY9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADCY9 for domains About GeneDecksing

2 InterPro domains/families:

IPR001054 A/G_cyclase

IPR018297 A/G_cyclase_CS

Graphical View of Domain Structure for InterPro Entry O60503

ProtoNet protein and cluster: O60503

UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503

Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family

Similarity: Contains 2 guanylate cyclase domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503

Function: May play a fundamental role in situations where fine interplay between intracellular calcium and cAMP

determines the cellular function. May be a physiologically relevant docking site for calcineurin (By similarity)

Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate

Enzyme regulation: Insensitive to calcium/calmodulin, forskolin and somatostatin. Stimulated by beta-adrenergic

receptor activation

Genatlas biochemistry entry for ADCY9:

adenylyl cyclase type IX,ubiquitously,with highest levels in skeletal muscle,heart and brain

Enzyme Number (IUBMB): EC 4.6.1.1¹ ²

miRNA Products:		OriGene 3'-UTR Clone: ADCY9 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY9
		8/66 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY9 (see all 66):
		hsa-miR-607 hsa-miR-193a-3p hsa-miR-640 hsa-miR-3074-3p hsa-miR-10b* hsa-miR-200b hsa-miR-376c hsa-miR-4273

		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY9 (see all 7) OriGene shRNA RFP: ADCY9 OriGene siRNA: ADCY9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY9

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ADCY9

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY9

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004016	adenylate cyclase activity	IEA	--
GO:0005524	ATP binding	IEA	--
GO:0016849	phosphorus-oxygen lyase activity	--	--
GO:0046872	metal ion binding	IEA	--

ADCY9 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ADCY9:

Synthetic lethal with cisplati

Animal Models:
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Adcy9):

immune system

ADCY9 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/53 super-pathways (see all 53) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PKA activation in glucagon signalling

8/12 pathways (see all 12)
PKA activation in glucagon signalling	1.00	Neurophysiological process_PGE2-induced pain processing	0.44
PKA activation	0.94	Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling	0.37
PKA-mediated phosphorylation of CREB	0.89	Development_Role of Activin A in cell differentiation and proliferation	0.33
Regulation of CFTR gating (normal and CF)	0.76	Development Role of Activin A in cell differentiation and proliferation	0.33

DAG and IP3 signaling

DAG and IP3 signaling	1.00	CaM pathway	0.84
PLC-gamma1 signalling	0.94	Calmodulin induced events	0.84
EGFR interacts with phospholipase C-gamma	0.94	Ca-dependent events	0.79
PLCG1 events in ERBB2 signaling	0.91	Phospholipase C-mediated cascade	0.57

Regulation of Water Balance by Renal Aquaporins

Regulation of Water Balance by Renal Aquaporins	1.00	G alpha (z) signalling events	0.48
Aquaporin-mediated transport	0.84	Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation	0.40
Glucagon signaling in metabolic regulation	0.69	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation	0.40

Opioid Signalling

Opioid Signalling	1.00	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics	0.35
G-protein mediated events	0.55	Glutamatergic synapse	0.31
PLC beta mediated events	0.54

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for ADCY9 (see all 9)

	Adenylate cyclase-activating neuropeptides
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development Beta-adrenergic receptors signaling via cAMP
	Signal transduction cAMP signaling
	Signal transduction PKA signaling

5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY9 (see all 23)

	MAPK Signaling
	PKA Signaling
	Molecular Mechanisms of Cancer
	Relaxin Pathway
	G-AlphaI Signaling

5/12 GeneGo (Thomson Reuters) Pathways for ADCY9 (see all 12)

	Development Beta-adrenergic receptors signaling via cAMP
	Signal transduction cAMP signaling
	Signal transduction PKA signaling
	Development Endothelin-1/EDNRA signaling
	Regulation of CFTR activity (norm and CF)

5/6 BioSystems Pathways for ADCY9 (see all 6)

	Calcium Regulation in the Cardiac Cell
	G Protein Signaling Pathways
	Myometrial Relaxation and Contraction Pathways
	Endothelins
	LPA receptor mediated events

5/50 Reactome Pathways for ADCY9 (see all 50)

	PKA activation
	Signaling by EGFR in Cancer
	G alpha (z) signalling events
	Downstream signal transduction
	Signal Transduction

2 PharmGKB Pathways for ADCY9

	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
	Proton Pump Inhibitor Pathway, Pharmacodynamics

5/19 Kegg Pathways (Kegg details for ADCY9) (see all 19):

	Purine metabolism
	Calcium signaling pathway
	Chemokine signaling pathway
	Oocyte meiosis
	Vascular smooth muscle contraction

ADCY9 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ADCY9

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/297 Interacting proteins for ADCY9 (ENSP00000294016⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 297)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADCY1	ENSP00000297323⁴	STRING: ENSP00000297323
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126
ADCY5	ENSP00000419361⁴	STRING: ENSP00000419361
ADCY6	ENSP00000311405⁴	STRING: ENSP00000311405

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006171	cAMP biosynthetic process	--	--
GO:0006833	water transport	TAS	--
GO:0007165	signal transduction	TAS	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--

ADCY9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADCY9 for compounds About GeneDecksing

EMD Millipore small molecules for ADCY9:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADCY9 available from Tocris Bioscience About this table

Compound	Action	CAS #
BPIPP	Non-competitive GC inhibitor. Also AC inhibitor	[325746-94-9]
NKH 477	Water-soluble adenylyl cyclase activator	[138605-00-2]
Forskolin	Adenylyl cyclase activator	[66575-29-9]
SQ 22536	Adenylyl cyclase inhibitor	[17318-31-9]
PACAP 1-38	Potent stimulator of adenylyl cyclase	--

10/11 HMDB Compounds for ADCY9 (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Cyclic GMP	3',5'-cyclic GMP (see all 13)	7665-99-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

5 Novoseek chemical compound relationships for ADCY9 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
forskolin	58.3	4	9463474 (2), 11226046 (1)
cyclic amp	50.9	2	11226046 (1), 17551263 (1)
adenylate	48	5	11840511 (3), 15794946 (1), 20175803 (1)
cyclosporin a	30.9	2	9822726 (1)
calcium	20	5	9822726 (1), 15794946 (1)

Search CenterWatch for drugs/clinical trials and news about ADCY9

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADCY9 gene:

NM_001116.3

Unigene Cluster for ADCY9:

Adenylate cyclase 9

Hs.391860 [show with all ESTs]

Unigene Representative Sequence: NM_001116

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000576936 ENST00000294016(uc002cvx.3) ENST00000574721 ENST00000575550

ENST00000571467 ENST00000571889 ENST00000572288

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		Browse SwitchGear 3'UTR luciferase reporter plasmids

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY9

Additional cDNA sequence:

AB011092.3 AF036927.1 AJ133123.1 BC068612.1 BC136657.1 BC136658.1 BC151207.1 BC151229.1

DQ005545.1 DQ008441.1

5 DOTS entries:

DT.455680 DT.97805016 DT.75141941 DT.95266612 DT.86849976

24/103 AceView cDNA sequences (see all 103):

AI572195 AI583402 Z40718 BF109524 BQ424543 AW470671 CA772679 BP350940

AU141090 BF475884 NM_001116 T08314 BE504143 BM797762 AI683180 BC068612

BM981110 BM453519 AI656244 M79050 AI814630 BX491245 CB959938 AK022108

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY9 (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13
SP1:											-		-						-
SP2:																			-		-		-		-
SP3:											-		-						-
SP4:													-						-		-
SP5:											-		-

ECgene alternative splicing isoforms for ADCY9

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADCY9 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ADCY9 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Limb

Forelimb Myotome

Limb Muscle Progenitor Cells

Skeletal Muscle

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADCY9 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCY9

SOURCE GeneReport for Unigene cluster: Hs.391860

UniProtKB/Swiss-Prot: ADCY9_HUMAN, O60503

Tissue specificity: Expressed in multiple cells of the lung, with expression highest in airway smooth muscle

SABiosciences Custom PCR Arrays for ADCY9

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY9

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADCY9 gene from 6/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADCY9¹	adenylate cyclase 9	77.64(n) 82.03(a)		395339 NM_204630.1 NP_989961.1
lizard (Anolis carolinensis)	Reptilia	ADCY9⁶	--	70(a)	1 ↔ 1	GL343856.1(90771-102904)
African clawed frog (Xenopus laevis)	Amphibia	adcy9²	adenylate cyclase 9	75.3(n)		Z46958.1
zebrafish (Danio rerio)	Actinopterygii	LOC100333702¹	adenylate cyclase type 9-like	64.99(n) 65.7(a)		100333702 XM_003201097.1 XP_003201145.1
fruit fly (Drosophila melanogaster)	Insecta	Ac13E^{1 , 3}	adenylate cyclase³ Adenylyl cyclase 35C¹	41(a)³ 53.19(n)¹ 43.89(a)¹		32485¹ NM_001014745.1¹ NP_001014745.1¹
worm (Caenorhabditis elegans)	Secernentea	acy-1^{1 , 3}	adenylate cyclase³ Protein ACY-1¹	44(a)³ 49.52(n)¹ 44.02(a)¹		III(4794001-4802353)³ 175622¹ NM_065569.2¹ NP_497970.1¹

ENSEMBL Gene Tree for ADCY9 (if available)
TreeFam Gene Tree for ADCY9 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ADCY9 gene

ADCY5² ADCY2² GUCY2D² GUCY2C² NPR1² ADCY8² GUCY2F² GUCY1A2²

ADCY7² GUCY1B3² ADCY6² GUCY1A3² ADCY1² ADCY4² NPR2² ADCY3²

2 SIMAP similar genes for ADCY9 using alignment to 6 protein entries: ADCY9_HUMAN (see all proteins):

ADCY4 ADCY3

ADCY9 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189093738^1,2		--	4012263(+)	`TACCTA/GCAATC`	1	--	ds500¹		0	--	--	--	--
rs62036942^1,2	F,	--	4012480(+)	`TAACAT/CAAACA`	1	--	ds500¹		2		NA EA	240
rs140024701^1,2	C,	--	4012508(+)	`TTGCC-/CTGTTTC`	1	--	ds500¹		0	--	--	--	--
rs11861193^1,2	C,F,H,	--	4012524(+)	`GTCATG/CACGTG`	1	--	ds500¹		2		NA WA	124
rs181167737^1,2		--	4012527(+)	`ATGACA/GTGAAA`	1	--	ds500¹		0	--	--	--	--
rs184957168^1,2		--	4012565(+)	`CAGATC/TGCAGA`	1	--	ds500¹		0	--	--	--	--
rs139380454^1,2		--	4012587(+)	`GTCCAA/GGGAAG`	1	--	ds500¹		0	--	--	--	--
rs150008470^1,2		--	4012794(+)	`AGATTA/CTAGGC`	1	--	ut3¹		0	--	--	--	--
rs56397731^1,2	C,	--	4012825(+)	`ACCAAT/CTAAAA`	1	--	ut3¹		2		WA	120
rs146577886^1,2		--	4013013(+)	`GAGCCC/TGTGGG`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADCY9 (4003388 - 4166186 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for ADCY9
5 CNVs: 72429 72428 4922 72434 72431
Human Gene Mutation Database (HGMD): ADCY9

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCY9

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ADCY9 for disorders           About GeneDecksing

OMIM gene information: 603302    OMIM disorders: --

16 diseases for ADCY9:    About MalaCards

precocious puberty thyroid adenoma rubinstein-taybi syndrome chondrodysplasia

adenoma thyroiditis mood disorder neuronitis

bipolar disorder asthma cholera malaria

immunodeficiency pancreatitis colorectal cancer breast cancer

1 disease from the University of Copenhagen DISEASES database for ADCY9:

Cholera

1 Novoseek disease relationship for ADCY9 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
asthma	29.2	1	15879435 (1)

Genetic Association Database (GAD): ADCY9
Human Genome Epidemiology (HuGE) Navigator: ADCY9 (7 documents)

Export disorders for ADCY9 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADCY9 gene, integrated from 9 sources (see all 47):
(articles sorted by number of sources associating them with ADCY9)

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Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). (PubMed id 9628827)^{1, 2, 3, 9} Hacker B.M.... Storm D.R. (1998)
Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. (PubMed id 11840511)^{1, 4, 9} Toyota T....Yoshikawa T. (2002)
Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. (PubMed id 15879435)^{1, 2, 9} Tantisira K.G.... Liggett S.B. (2005)
An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. (PubMed id 12972952)^{1, 2, 9} Small K.M....Liggett S.B. (2003)
Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder. (PubMed id 12082561)^{1, 4} Toyota T....Yoshikawa T. (2002)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2} Nagase T....Ohara O. (1998)
Identification and characterization of a widely expressed form of adenylyl cyclase. (PubMed id 8662814)^{1, 9} Premont R.T....Hanoune J. (1996)
Novel regulatory properties of human type 9 adenylate cyclase. (PubMed id 14996950)^{1, 9} Cumbay M.G. and Watts V.J. (2004)
Pharmacogenetic study of the effects of NK2R G231E G& gt;A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled cortico steroid treatment. (PubMed id 20175803)^{1, 9} Ye Y.M....Park H.S. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 115	HGNC: 240	AceView: ADCY9	Ensembl:ENSG00000162104	euGenes: HUgn115
ECgene: ADCY9	Kegg: 115	H-InvDB: ADCY9

(According to HUGE)
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HUGE: KIAA0520

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADCY9	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADCY9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADCY9 gene:
Search GeneIP for patents involving ADCY9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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adenylate cyclase 9

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adenylate cyclase 9

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