ADCY8 Gene
protein-coding GIFtS: 66
GCID: GC08M131861
|
|
adenylate cyclase 8 (brain)
(Previous symbol: ADCY3)
| |
Aliases
for ADCY8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenylate Cyclase 8 (Brain)1 2 | | Ca(2+)/Calmodulin-Activated Adenylyl Cyclase2 3 | | AC81 2 3 | | ATP Pyrophosphate-Lyase 82 3 | | ADCY31 2 5 | | EC 4.6.1.13 8 | | HBAC11 2 | | Adenylate Cyclase Type 82 | | Adenylate Cyclase Type VIII2 3 | | Adenylyl Cyclase-8, Brain2 | | Adenylyl Cyclase 82 3 | | |
Export aliases for ADCY8 gene to outside databasesPrevious GC identifers: GC08M130592 GC08M131808 GC08M131463 GC08M131749 GC08M131725 GC08M127112 |
Summaries
for ADCY8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADCY8:
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymaticactivity is under the control of several hormones, and different polypeptides participate in the transduction of thesignal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with Gproteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of theadenylyl cyclase (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ADCY8_HUMAN, P40145Function: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and indrug dependence (By similarity)
 summary
for ADCY8: Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.
Gene Wiki entry for ADCY8
|
Genomic Views
for ADCY8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADCY8 gene promoter:
Pax-5 Sp1 LCR-F1 C/EBPalpha Egr-4 FOXO4 FOXO1a Pax-4a FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADCY8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24 Ensembl cytogenetic band: 8q24.22 HGNC cytogenetic band: 8q24ADCY8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M131861: view genomic region
(about GC identifiers)
Start:
|
131,792,547 bp from pter |
End:
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132,054,672 bp from pter |
Size:
|
262,126 bases |
Orientation:
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minus strand |
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Proteins
for ADCY8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADCY8_HUMAN, P40145 (See
protein sequence)Recommended Name: Adenylate cyclase type 8 Size: 1251 amino acids; 140122 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subcellular location: Membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for ADCY8: NX_P40145
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P40145
4/11 DME Specific Peptides for ADCY8 (P40145) (see all 11)
ADCY8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001106.1
ENSEMBL proteins: ENSP00000286355 ENSP00000367161 ENSP00000428010 Reactome Protein details: P40145
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
ADCY8 for ontologies About GeneDecksing
ADCY8 Antibody Products:
Assay Products for ADCY8: |
Protein
Domains /
Families
for ADCY8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADCY8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P40145ProtoNet protein and cluster: P40145 1 Blocks protein family: IPB009398 Adenylate cyclase-like
UniProtKB/Swiss-Prot: ADCY8_HUMAN, P40145Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase familySimilarity: Contains 2 guanylate cyclase domains |
Function
for ADCY8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADCY8_HUMAN, P40145Function: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and indrug dependence (By similarity)Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphateEnzyme regulation: Activated by calcium/calmodulin Genatlas biochemistry entry for ADCY8:adenylyl cyclase type VIII,brain
Enzyme Number (IUBMB): EC 4.6.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADCY8 (NM_001115) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCY8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY8 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY8 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ADCY8 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ADCY8:
Animal Models:
Mouse knock-out Adcy8tm1Ljm for ADCY8
6 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Adcy8):
ADCY8 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADCY8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/55 super-pathways (see all 55) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PKA activation in glucagon signalling | | | 3 | DAG and IP3 signaling | | | 4 | Regulation of Water Balance by Renal Aquaporins | | | 5 | Opioid Signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/9 EMD Millipore Pathways for ADCY8 (see all 9)
5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY8 (see all 23)
5/12  GeneGo (Thomson Reuters) Pathways for ADCY8 (see all 12)
5/7  BioSystems Pathways for ADCY8 (see all 7)
5/55 
Reactome Pathways for ADCY8 (see all 55)
2  PharmGKB Pathways for ADCY8
5/18 
Kegg Pathways (Kegg details for ADCY8) (see all 18):
ADCY8 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADCY8
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/304 Interacting proteins for ADCY8 (P401453 ENSP000002863554) via UniProtKB, MINT, STRING, and/or I2D (see all 304)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006112 | energy reserve metabolic process |
TAS | -- | | GO:0006171 | cAMP biosynthetic process |
-- | -- | | GO:0006833 | water transport |
TAS | -- | | GO:0007165 | signal transduction |
TAS | -- | | GO:0007173 | epidermal growth factor receptor signaling pathway |
TAS | -- |
ADCY8 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADCY8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Compounds for ADCY8 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| BPIPP | Non-competitive GC inhibitor. Also AC inhibitor | [325746-94-9] | | NKH 477 | Water-soluble adenylyl cyclase activator | [138605-00-2] | | Forskolin | Adenylyl cyclase activator | [66575-29-9] | | SQ 22536 | Adenylyl cyclase inhibitor | [17318-31-9] | | PACAP 1-38 | Potent stimulator of adenylyl cyclase | -- |
10/11 HMDB Compounds for ADCY8 (see all 11) About this table
Search CenterWatch for drugs/clinical trials and news about ADCY8
|
Transcripts
for ADCY8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADCY8 gene: NM_001115.2 Unigene Cluster for ADCY8: Adenylate cyclase 8 (brain) Hs.591859 [show with all ESTs]Unigene Representative Sequence: Z353093 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000286355(uc003ytd.4 uc010mds.3) ENST00000377928 ENST00000522949
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY8 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADCY8 (NM_001115) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCY8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY8 |
Additional cDNA sequence: DQ104739.1 M83533.1 Z35309.1 3 DOTS entries: DT.310181 DT.120630234 DT.95295326 21 AceView cDNA sequences: BE048304 M83533 CK001209 Z35309 AA463281 AI674049 NM_001115 BG314946 BF340768 AW002651 BG315046 R61009 R44767 AI866507 BF919001 BG206938 AA961399 BE501141 CK005278 BF954991 R19100
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY8 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ADCY8
|
Expression
for ADCY8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADCY8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGTGTCAG
About this image
See ADCY8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCY8
SOURCE GeneReport for Unigene cluster: Hs.591859
SABiosciences Expression via Pathway-Focused PCR Array including ADCY8:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY8
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCY8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY8 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY8 |
Orthologs
for ADCY8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADCY8 gene from 5/22 species (see all 22) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADCY81 |
adenylate cyclase 8 (brain) |
81.28(n)
91.33(a) |
|
420328 XM_418437.3 XP_418437.2 |
lizard
(Anolis carolinensis) |
Reptilia |
ADCY86 |
-- |
92(a) |
1 ↔ 1 |
4(3500110-3572804) |
zebrafish
(Danio rerio) |
Actinopterygii |
adcy81 |
adenylate cyclase 8 (brain) |
74.91(n)
83.4(a) |
|
100148976 NM_001143752.1 NP_001137224.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
rut3
Ac78C1 |
molting cycle (sensu Insecta) adenylate
cyclase3
Adenylyl cyclase 78C1 |
45(a)
(best of 8)3
51.99(n)1
42.36(a)1 |
|
12F43
403331 NM_079470.41 NP_524194.31 |
worm
(Caenorhabditis elegans) |
Secernentea |
acy-43 |
-- |
41(a)
(best of 2) |
|
V(5627531-5629064) -- |
ENSEMBL Gene Tree for ADCY8 (if available)
TreeFam Gene Tree for ADCY8 (if available) |
Paralogs
for ADCY8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADCY8 gene
- ADCY52 ADCY22 GUCY2D2 GUCY2C2 NPR12 GUCY2F2 GUCY1A22 ADCY72
- ADCY92 GUCY1B32 ADCY62 GUCY1A32 ADCY12 ADCY42 NPR22 ADCY32
9 SIMAP similar genes for ADCY8 using alignment to 5 protein entries: ADCY8_HUMAN (see all proteins):DKFZp686J099 ADCY7 ADCY6 ADCY1 ADCY3 ADCY4
ADCY5 NPR1 ADCY2
ADCY8 for paralogs About GeneDecksing
|
Genomic Variants
for ADCY8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADCY8 (131792547 - 132042547 bp, first 250kb of ADCY8)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for ADCY8
6 CNVs: 82771 65266 6668 62856 59454 95687
1 Indel: 100503
Human Gene Mutation Database (HGMD): ADCY8
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCY8 |
|
Disorders
/ Diseases
for ADCY8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADCY8 for disorders About GeneDecksing
OMIM gene information: 103070
OMIM disorders: --
15  diseases for ADCY8: About MalaCardsprecocious puberty thyroid adenoma chondrodysplasia adenoma
thyroiditis drug dependence mood disorder neuronitis
bipolar disorder cholera alzheimer's disease colorectal cancer
immunodeficiency pancreatitis breast cancer
1 disease from the University of Copenhagen DISEASES database for ADCY8:Cholera Human Genome Epidemiology (HuGE) Navigator: ADCY8 (6 documents)
Export disorders for ADCY8 gene to outside databases
|
Publications
for ADCY8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADCY8 gene, integrated from 9 sources (see all 43):
(articles sorted by number of sources associating them with ADCY8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of the human type VIII adenylyl cyclase. (PubMed id 8076676)1, 2, 3 Defer N.... Hanoune J. (1994)
- Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain. (PubMed id 1715695)1, 2 Parma J.... Hanoune J. (1991)
- Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling. (PubMed id 22494970)1 Willoughby D....Cooper D.M. (2012)
- Adenylyl cyclase 8 is central to glucagon-like peptid e 1 signalling and effects of chronically elevated glucose in rat and human pan creatic beta cells. (PubMed id 21046358)1 Roger B....Lang J. (2011)
- An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1 Shimada M....Tokunaga K. (2010)
- Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1 Furney S.J....Lovestone S. (2010)
- Crosstalk between adenylyl cyclase signaling pathway and Ca2+ regulatory mechanism under red blood cell microrheological changes. (PubMed id 20675917)1 Muravyov A.V....Batalova E.A. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- AKAP79/150 interacts with AC8 and regulates Ca2+-depe ndent cAMP synthesis in pancreatic and neuronal systems. (PubMed id 20410303)1 Willoughby D....Cooper D.M. (2010)
- Capacitative Ca2+ entry via Orai1 and stromal interacting molecule 1 (STIM1) regulates adenylyl cyclase type 8. (PubMed id 19171672)1 Martin A.C....Cooper D.M. (2009)
|
External Searches for ADCY8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADCY8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADCY8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADCY8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ADCY8 gene:
Search GeneIP for patents involving ADCY8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADCY8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADCY8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY8 | | | OriGene Protein Over-expression Lysate for ADCY8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADCY8 | | OriGene 3'-UTR Clone for ADCY8 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADCY8 | | OriGene Custom Protein Services for ADCY8 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADCY8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCY8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY8 |
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| | | | Tocris compounds for ADCY8 |
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 | | | ADCY8 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY8 |
|  |  |  | | | | Search ThermoFisher Antibodies for ADCY8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY8 |
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