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ADCY8 Gene

protein-coding   GIFtS: 70
GCID: GC08M131861

Adenylate Cyclase 8 (Brain)


(Previous symbol: ADCY3)
  See ADCY8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase 8 (Brain)1 2     ATP Pyrophosphate-Lyase 82 3
ADCY31 2 5     EC 4.6.1.13 8
Adenylate Cyclase Type VIII2 3     HBAC12
Adenylyl Cyclase 82 3     Adenylate Cyclase Type 82
Ca(2+)/Calmodulin-Activated Adenylyl Cyclase2 3     Adenylyl Cyclase-8, Brain2
AC82 3     

External Ids:    HGNC: 2391   Entrez Gene: 1142   Ensembl: ENSG000001558977   OMIM: 1030705   UniProtKB: P401453   

Export aliases for ADCY8 gene to outside databases

Previous GC identifers: GC08M130592 GC08M131808 GC08M131463 GC08M131749 GC08M131725 GC08M127112


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCY8 Gene:
Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic
activity is under the control of several hormones, and different polypeptides participate in the transduction of
the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact
with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit
of the adenylyl cyclase (provided by RefSeq, Jul 2008)

GeneCards Summary for ADCY8 Gene:
ADCY8 (adenylate cyclase 8 (brain)) is a protein-coding gene. Diseases associated with ADCY8 include thyroid adenoma, and precocious puberty. GO annotations related to this gene include calcium- and calmodulin-responsive adenylate cyclase activity and adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY8_HUMAN, P40145
Function: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory
and in drug dependence (By similarity)

summary for ADCY8 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCY8 gene promoter:
         Pax-5   Sp1   LCR-F1   C/EBPalpha   Egr-4   FOXO4   FOXO1a   Pax-4a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCY8 promoter sequence
   Search Chromatin IP Primers for ADCY8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCY8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24   Ensembl cytogenetic band:  8q24.22   HGNC cytogenetic band: 8q24

ADCY8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY8 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M131861:  view genomic region     (about GC identifiers)

Start:
131,792,547 bp from pter      End:
132,054,672 bp from pter
Size:
262,126 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADCY8_HUMAN, P40145 (See protein sequence)
Recommended Name: Adenylate cyclase type 8  
Size: 1251 amino acids; 140122 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)

Explore the universe of human proteins at neXtProt for ADCY8: NX_P40145

Explore proteomics data for ADCY8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn817, Asn821, Asn888
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADCY8 (P40145) (see all 11)
     EKIKTIG  SRMDSTGV  TYMAVSGL  VDMRIGIH 


    See ADCY8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001106.1  
    ENSEMBL proteins: 
     ENSP00000286355   ENSP00000367161   ENSP00000428010  
    Reactome Protein details: P40145

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    Cloud-Clone Corp. Proteins for ADCY8

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC8
    Adenylyl cyclases

    3 InterPro protein domains:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry P40145

    ProtoNet protein and cluster: P40145

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY8_HUMAN, P40145
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    Find genes that share domains with ADCY8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY8_HUMAN, P40145
    Function: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory
    and in drug dependence (By similarity)
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Activated by calcium/calmodulin

         Genatlas biochemistry entry for ADCY8:
    adenylyl cyclase type VIII,brain

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity TAS8076676
    GO:0005524ATP binding IEA--
    GO:0008294calcium- and calmodulin-responsive adenylate cyclase activity TAS8163524
    GO:0016849phosphorus-oxygen lyase activity ----
         
    Find genes that share ontologies with ADCY8           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADCY8:
     Increased cell number in G1, s  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adcy8):
     behavior/neurological  growth/size/body  homeostasis/metabolism  integument  nervous system 
     taste/olfaction 

    Find genes that share phenotypes with ADCY8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adcy8tm1Ljm for ADCY8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADCY8
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY8

    miRNA
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    miRTarBase miRNAs that target ADCY8:
    hsa-mir-1296-5p (MIRT036106), hsa-mir-1301-3p (MIRT035974), hsa-mir-877-5p (MIRT037340), hsa-mir-124-3p (MIRT022973)

    Block miRNA regulation of human, mouse, rat ADCY8 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate ADCY8:
    hsa-miR-3613-3p
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADCY8_HUMAN, P40145: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol2
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane TAS8163524
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ADCY8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCY8 About   (see all 57)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Adenylate cyclase inhibitory pathway
    Adenylate cyclase inhibitory pathway0.53
    Inhibition of adenylate cyclase pathway0.00
    LPA4-mediated signaling events0.53
    Adenylate cyclase activating pathway0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Long-term potentiation0.35
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90


    Find genes that share SuperPaths with ADCY8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADCY8 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ADCY8 (see all 12)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    Selected BioSystems Pathways for ADCY8 (see all 7)
        Myometrial Relaxation and Contraction Pathways
    Hypothetical Network for Drug Addiction
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events

    Selected Reactome Pathways for ADCY8 (see all 11)
        PKA activation
    CREB phosphorylation through the activation of Adenylate Cyclase
    PKA activation in glucagon signalling
    G alpha (z) signalling events
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion

    2 PharmGKB Pathways for ADCY8
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADCY8) (see all 31):
        Purine metabolism
    Rap1 signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis

        Pathway & Disease-focused RT2 Profiler PCR Array including ADCY8: 
              Synaptic Plasticity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADCY8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCY8 (P401453 ENSP000002863554) via UniProtKB, MINT, STRING, and/or I2D (see all 314)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALM1P621583, ENSP000003494674I2D: score=2 STRING: ENSP00000349467
    CALM2P621583, ENSP000002722984I2D: score=2 STRING: ENSP00000272298
    CALM3P621583I2D: score=2 
    PPP2CAP677753, ENSP000004184474I2D: score=1 STRING: ENSP00000418447
    CFTRP135693I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway TAS--

    Find genes that share ontologies with ADCY8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADCY8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    Selected HMDB Compounds for ADCY8 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADCY8 gene: 
    NM_001115.2  

    Unigene Cluster for ADCY8:

    Adenylate cyclase 8 (brain)
    Hs.591859  [show with all ESTs]
    Unigene Representative Sequence: Z35309
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286355(uc003ytd.4 uc010mds.3) ENST00000377928 ENST00000522949

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    Additional mRNA sequence: 

    DQ104739.1 M83533.1 Z35309.1 

    3 DOTS entries:

    DT.310181  DT.120630234  DT.95295326 

    21 AceView cDNA sequences:

    BE048304 M83533 NM_001115 AI674049 CK001209 Z35309 AA463281 BG315046 
    R61009 BF340768 AW002651 BG314946 AI866507 BG206938 R44767 BF919001 
    AA961399 BE501141 CK005278 BF954991 R19100 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY8    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:                                                                                                                  
    SP2:                                                  -     -     -                                                   


    ECgene alternative splicing isoforms for ADCY8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADCY8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCGTGTCAG
    ADCY8 Expression
    About this image


    ADCY8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    ADCY8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCY8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591859
        Pathway & Disease-focused RT2 Profiler PCR Array including ADCY8: 
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADCY8 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy81 , 5 adenylate cyclase 81, 5 90.21(n)1
    96.96(a)1
      15 (29.03 cM)5
    115141  NM_009623.21  NP_033753.21 
     646990425 
    chicken
    (Gallus gallus)
    Aves ADCY81 adenylate cyclase 8 (brain) 81.04(n)
    90.79(a)
      420328  XM_418437.4  XP_418437.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY86
    adenylate cyclase 8 (brain)
    89(a)
    1 ↔ 1
    4(3427098-3572891)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adcy81 adenylate cyclase 8 (brain) 79.42(n)
    90.83(a)
      100124758  NM_001102737.1  NP_001096207.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adcy81 adenylate cyclase 8 (brain) 74.61(n)
    82.96(a)
      100148976  NM_001143752.1  NP_001137224.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rut3
    Ac78C1
    molting cycle (sensu Insecta) adenylate
    cyclase3
    Adenylyl cyclase 78C1
    45(a)
    (best of 8)3
    52.28(n)1
    42.46(a)1
      12F43
    403331  NM_001275208.11  NP_001262137.11 
    worm
    (Caenorhabditis elegans)
    Secernentea acy-43   -- 41(a)
    (best of 2)
      V(5627531-5629064)   --


    ENSEMBL Gene Tree for ADCY8 (if available)
    TreeFam Gene Tree for ADCY8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADCY8 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  GUCY2F2  GUCY1A22  ADCY72  
    ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    9 SIMAP similar genes for ADCY8 using alignment to 5 protein entries:     ADCY8_HUMAN (see all proteins):
    DKFZp686J099    ADCY7    ADCY6    ADCY1    ADCY4    ADCY5
    ADCY3    NPR1    ADCY2

    Find genes that share paralogs with ADCY8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADCY8 (see all 5630)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0363284
    A colorectal cancer sample4--see VAR_0363282 F L mis40--------
    rs1810961681,2
    --131792060(+) ACCTCA/TATCTG 1 -- ds50010--------
    rs1440298621,2
    --131792163(+) ATTTCA/CCTGGA 1 -- ds50010--------
    rs1504803311,2
    C--131792176(+) TAGGA-/CCCCC 
            
    CAGCC
    1 -- ds50010--------
    rs1861390511,2
    --131792177(+) TAGGAC/GAGCCA 1 -- ds50010--------
    rs1889463151,2
    --131792213(+) ATACTG/TATGAA 1 -- ds50010--------
    rs2632471,2
    C,F,A,H--131792219(+) ATGAAT/CGTACT 1 -- ds500129Minor allele frequency- C:0.41EA NS NA WA CSA 2947
    rs765428251,2
    C,F--131792243(+) GAGGAT/CTACAG 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs799004951,2
    C,F--131792363(+) GTCCCA/CCTCTT 1 -- ds50011Minor allele frequency- C:0.09WA 118
    rs1486538811,2
    --131792429(+) CTTTGA/CCTCCC 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADCY8 (131792547 - 132042547 bp, first 250kb of ADCY8)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADCY8 (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675868CNV Deletion23128226
    esv1000595CNV Deletion20482838
    nsv821256CNV Deletion20802225
    esv1011202CNV Deletion20482838
    esv2669733CNV Deletion23128226
    esv2737587CNV Deletion23290073
    esv1235416CNV Deletion17803354
    nsv6397CNV Insertion18451855
    nsv512966CNV Insertion21212237
    esv2655219CNV Insertion19546169

    Human Gene Mutation Database (HGMD): ADCY8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADCY8
    DNA2.0 Custom Variant and Variant Library Synthesis for ADCY8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103070    OMIM disorders: --

    3 diseases for ADCY8:    
    About MalaCards
    thyroid adenoma    precocious puberty    adenoma

    1 disease from the University of Copenhagen DISEASES database for ADCY8:
    Cholera

    Find genes that share disorders with ADCY8           About GenesLikeMe

    Genetic Association Database (GAD): ADCY8
    Human Genome Epidemiology (HuGE) Navigator: ADCY8 (6 documents)

    Export disorders for ADCY8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADCY8 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with ADCY8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the human type VIII adenylyl cyclase. (PubMed id 8076676)1, 2, 3 Defer N.... Hanoune J. (FEBS Lett. 1994)
    2. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PubMed id 21116278)1, 4 Furney S.J.... . (Mol. Psychiatry 2011)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    6. Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain. (PubMed id 1715695)1, 2 Parma J.... Hanoune J. (Biochem. Biophys. Res. Commun. 1991)
    7. GI+(h)/transglutaminase-2 activity is required for maximal activation of adenylylcyclase 8 in human and rat glioma cells. (PubMed id 23200849)1 Obara Y....Nakahata N. (Cell. Signal. 2013)
    8. Genetic markers of comorbid depression and alcoholism in women. (PubMed id 23278386)1 Procopio D.O....Tabakoff B. (Alcohol. Clin. Exp. Res. 2013)
    9. Direct binding between Orai1 and AC8 mediates dynamic interplay between Ca2+ and cAMP signaling. (PubMed id 22494970)1 Willoughby D....Cooper D.M. (Sci Signal 2012)
    10. Adenylyl cyclase 8 is central to glucagon-like peptide 1 signalling and effects of chronically elevated glucose in rat and human pancreatic beta cells. (PubMed id 21046358)1 Roger B....Lang J. (Diabetologia 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114 HGNC: 239 AceView: ADCY8 Ensembl:ENSG00000155897 euGenes: HUgn114
    ECgene: ADCY8 Kegg: 114 H-InvDB: ADCY8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADCY8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADCY8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADCY8 gene:
    Search GeneIP for patents involving ADCY8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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