Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADCY8 Gene

Aliases for ADCY8 Gene

  • Adenylate Cyclase 8 (Brain) 2 3
  • Ca(2+)/Calmodulin-Activated Adenylyl Cyclase 3 4
  • Adenylate Cyclase Type VIII 3 4
  • ATP Pyrophosphate-Lyase 8 3 4
  • Adenylyl Cyclase 8 3 4
  • EC 4.6.1.1 4 64
  • ADCY3 3 6
  • AC8 3 4
  • Adenylyl Cyclase-8, Brain 3
  • Adenylate Cyclase Type 8 3
  • HBAC1 3

External Ids for ADCY8 Gene

Previous Symbols for ADCY8 Gene

  • ADCY3

Summaries for ADCY8 Gene

Entrez Gene Summary for ADCY8 Gene

  • Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY8 Gene

ADCY8 (Adenylate Cyclase 8 (Brain)) is a Protein Coding gene. Diseases associated with ADCY8 include adenoma and thyroid adenoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include adenylate cyclase activity and calcium- and calmodulin-responsive adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY8 Gene

  • This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Tocris Summary for ADCY8 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5-triphosphate (ATP) into 3,5-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY8 Gene

Genomics for ADCY8 Gene

Genomic Location for ADCY8 Gene

Start:
130,780,300 bp from pter
End:
131,042,426 bp from pter
Size:
262,127 bases
Orientation:
Minus strand

Genomic View for ADCY8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY8 Gene

Regulatory Elements for ADCY8 Gene

Proteins for ADCY8 Gene

  • Protein details for ADCY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40145-ADCY8_HUMAN
    Recommended name:
    Adenylate cyclase type 8
    Protein Accession:
    P40145
    Secondary Accessions:

    Protein attributes for ADCY8 Gene

    Size:
    1251 amino acids
    Molecular mass:
    140122 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for ADCY8 Gene

Proteomics data for ADCY8 Gene at MOPED

Post-translational modifications for ADCY8 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn817, Asn821, and Asn888

Other Protein References for ADCY8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADCY8 Gene

Gene Families for ADCY8 Gene

HGNC:
  • ADCY :Adenylate cyclases
IUPHAR :

Protein Domains for ADCY8 Gene

UniProtKB/Swiss-Prot:

ADCY8_HUMAN
Domain:
  • Contains 2 guanylate cyclase domains.:
    • P40145
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.:
    • P40145
genes like me logo Genes that share domains with ADCY8: view

Function for ADCY8 Gene

Molecular function for ADCY8 Gene

GENATLAS Biochemistry: adenylyl cyclase type VIII,brain
UniProtKB/Swiss-Prot CatalyticActivity: ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by calcium/calmodulin
UniProtKB/Swiss-Prot Function: This is a membrane-bound, calcium-stimulable adenylyl cyclase. May be involved in learning, in memory and in drug dependence (By similarity).

Enzyme Numbers (IUBMB) for ADCY8 Gene

Gene Ontology (GO) - Molecular Function for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004016 adenylate cyclase activity TAS 8076676
GO:0005524 ATP binding IEA --
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity TAS 8163524
GO:0016849 phosphorus-oxygen lyase activity --
genes like me logo Genes that share ontologies with ADCY8: view
genes like me logo Genes that share phenotypes with ADCY8: view

Animal Models for ADCY8 Gene

MGI Knock Outs for ADCY8:

miRNA for ADCY8 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for ADCY8 Gene

Localization for ADCY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY8 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY8 Gene COMPARTMENTS Subcellular localization image for ADCY8 gene
Compartment Confidence
plasma membrane 4
cytosol 2
nucleus 1

Gene Ontology (GO) - Cellular Components for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane TAS 8163524
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCY8: view

Pathways for ADCY8 Gene

SuperPathways for ADCY8 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY8: view

Gene Ontology (GO) - Biological Process for ADCY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process IEA --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY8: view

Compounds for ADCY8 Gene

(5) Tocris Compounds for ADCY8 Gene

Compound Action Cas Number
KH 7 Selective soluble adenylyl cyclase inhibitor [330676-02-3]
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(11) HMDB Compounds for ADCY8 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ADCY8: view

Transcripts for ADCY8 Gene

mRNA/cDNA for ADCY8 Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADCY8 Gene

Adenylate cyclase 8 (brain):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY8 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1:
SP2: - - -

Relevant External Links for ADCY8 Gene

GeneLoc Exon Structure for
ADCY8
ECgene alternative splicing isoforms for
ADCY8

Expression for ADCY8 Gene

mRNA expression in normal human tissues for ADCY8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY8 Gene

This gene is overexpressed in Brain - Amygdala (5.4), Brain - Hippocampus (4.7), and Brain - Anterior cingulate cortex (BA24) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCY8 Gene

SOURCE GeneReport for Unigene cluster for ADCY8 Gene Hs.591859

genes like me logo Genes that share expressions with ADCY8: view

Orthologs for ADCY8 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY8 36
  • 99.19 (n)
  • 99.51 (a)
ADCY8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCY8 36
  • 91.79 (n)
  • 97.68 (a)
ADCY8 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY8 36
  • 92.27 (n)
  • 97.6 (a)
ADCY8 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy8 36
  • 90.21 (n)
  • 96.96 (a)
Adcy8 16
Adcy8 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCY8 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY8 37
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy8 36
  • 90.28 (n)
  • 97.04 (a)
chicken
(Gallus gallus)
Aves ADCY8 36
  • 81.04 (n)
  • 90.79 (a)
ADCY8 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY8 37
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy8 36
  • 79.42 (n)
  • 90.83 (a)
zebrafish
(Danio rerio)
Actinopterygii adcy8 36
  • 74.61 (n)
  • 82.96 (a)
adcy8 37
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002262 36
  • 53.07 (n)
  • 42.5 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ac78C 36
  • 52.28 (n)
  • 42.46 (a)
ACXC 38
  • 29 (a)
ACXD 38
  • 28 (a)
ACXA 38
  • 28 (a)
Ac3 38
  • 36 (a)
rut 38
  • 45 (a)
Ac78C 38
  • 43 (a)
ACXB 38
  • 30 (a)
ACXE 38
  • 28 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-4 37
  • 33 (a)
OneToOne
acy-2 38
  • 36 (a)
acy-4 38
  • 41 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 40 (a)
OneToMany
-- 37
  • 49 (a)
OneToMany
Species with no ortholog for ADCY8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY8 Gene

ENSEMBL:
Gene Tree for ADCY8 (if available)
TreeFam:
Gene Tree for ADCY8 (if available)

Paralogs for ADCY8 Gene

Selected SIMAP similar genes for ADCY8 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY8: view

Variants for ADCY8 Gene

Sequence variations from dbSNP and Humsavar for ADCY8 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs16929 -- 130,946,013(-) AAAAA(G/T)AGCAT intron-variant
rs70994 -- 130,809,676(-) ACTAG(C/T)GTGTG intron-variant
rs166402 -- 130,800,921(-) TTTGC(C/T)TTGCT intron-variant
rs166403 -- 130,823,072(+) CTGCC(C/T)GGCAC intron-variant
rs166404 -- 130,816,335(+) GAAAA(C/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY8 Gene

Variant ID Type Subtype PubMed ID
nsv891448 CNV Gain 21882294
nsv831462 CNV Gain 17160897
esv1011202 CNV Deletion 20482838
nsv512069 CNV Loss 21212237
esv2669733 CNV Deletion 23128226
dgv1195n67 CNV Gain 20364138
nsv821256 CNV Deletion 20802225
nsv824732 CNV Loss 20364138
nsv819677 CNV Gain 19587683
esv2737587 CNV Deletion 23290073
esv6594 CNV Loss 19470904
esv1000595 CNV Deletion 20482838
esv2675868 CNV Deletion 23128226
nsv396197 CNV Loss 16902084
esv25237 CNV Gain+Loss 19812545
nsv525692 CNV Gain 19592680
esv1235416 CNV Deletion 17803354
nsv512966 CNV Insertion 21212237
esv2655219 CNV Insertion 19546169
nsv6397 CNV Insertion 18451855
nsv891449 CNV Loss 21882294

Relevant External Links for ADCY8 Gene

HapMap Linkage Disequilibrium report
ADCY8
Human Gene Mutation Database (HGMD)
ADCY8

Disorders for ADCY8 Gene

(1) University of Copenhagen DISEASES for ADCY8 Gene

Relevant External Links for ADCY8

Genetic Association Database (GAD)
ADCY8
Human Genome Epidemiology (HuGE) Navigator
ADCY8
genes like me logo Genes that share disorders with ADCY8: view

No data available for UniProtKB/Swiss-Prot for ADCY8 Gene

Publications for ADCY8 Gene

  1. Molecular cloning of the human type VIII adenylyl cyclase. (PMID: 8076676) Defer N. … Hanoune J. (FEBS Lett. 1994) 2 3 4
  2. Sequence of a human brain adenylyl cyclase partial cDNA: evidence for a consensus cyclase specific domain. (PMID: 1715695) Parma J. … Hanoune J. (Biochem. Biophys. Res. Commun. 1991) 3 4
  3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 49
  4. Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease. (PMID: 21116278) Furney S.J. … . (Mol. Psychiatry 2011) 3 49
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49

Products for ADCY8 Gene

Sources for ADCY8 Gene

Back to Top

Content