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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADCY7 Gene

protein-coding GIFtS: 67
GCID: GC16P050347

adenylate cyclase 7

Explore 13 diseases affiliated with
ADCY7 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenylate Cyclase 7¹ ²		ATP Pyrophosphate-Lyase 7² ³
AC7¹ ²		EC 4.6.1.1³ ⁸
KIAA0037¹ ³		Adenylate Cyclase Type 7²
Adenylate Cyclase Type VII² ³		EC 4.6.1⁸
Adenylyl Cyclase 7² ³

External Ids:	HGNC: 238¹	Entrez Gene: 113²	Ensembl: ENSG00000121281⁷	OMIM: 600385⁵	UniProtKB: P51828³

Export aliases for ADCY7 gene to outside databases

Previous GC identifers: GC16P040735 GC16P050045 GC16P050099 GC16P048880 GC16P036209

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCY7:

This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is

inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme

family that is characterized by the presence of twelve membrane-spanning domains in its sequences. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828

Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase

summary for ADCY7:

Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into

3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;

nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and

muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase

isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8

are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are

distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive

and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,

phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this

enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid

addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and

chondrodysplasia.

Gene Wiki entry for ADCY7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADCY7 gene promoter:
CREB GR deltaCREB GR-beta STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADCY7 promoter sequence

Search SABiosciences Chromatin IP Primers for ADCY7

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY7

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1 Ensembl cytogenetic band: 16q12.1 HGNC cytogenetic band: 16q12.1

ADCY7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY7 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P050347: view genomic region (about GC identifiers)

Start:	50,280,048 bp from pter	End:	50,352,046 bp from pter
Size:	71,999 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828 (See protein sequence)

Recommended Name: Adenylate cyclase type 7

Size: 1080 amino acids; 120308 Da

Cofactor: Binds 2 magnesium ions per subunit (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAA05021.2; Type=Erroneous initiation;

Secondary accessions: A0AVA6

Explore the universe of human proteins at neXtProt for ADCY7: NX_P51828

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51828

4/16 DME Specific Peptides for ADCY7 (P51828) (see all 16)

WQYDVWS

ASRMEST

EKIKTIG

GNVLCGV

ADCY7 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001105.1

ENSEMBL proteins:

ENSP00000460636 ENSP00000378187 ENSP00000445046 ENSP00000454301 ENSP00000457409

ENSP00000460018 ENSP00000455670 ENSP00000254235 ENSP00000437788

Reactome Protein details: P51828
Human Recombinant Protein Products for ADCY7:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
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	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: ADCY7 OriGene Custom Protein Services for ADCY7
	GenScript Custom Purified and Recombinant Proteins Services for ADCY7
	Novus Biologicals ADCY7 Protein Novus Biologicals ADCY7 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADCY7

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IDA	11113152

ADCY7 for ontologies About GeneDecksing

ADCY7 Antibody Products:

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	Abcam antibodies for ADCY7
	Uscn Antibodies for ADCY7
	ThermoFisher Antibody for ADCY7

Assay Products for ADCY7:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADCY7
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADCY7

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADCY7 for domains About GeneDecksing

3 InterPro domains/families:

IPR009398 Adenylate_cyclase-like

IPR001054 A/G_cyclase

IPR018297 A/G_cyclase_CS

Graphical View of Domain Structure for InterPro Entry P51828

ProtoNet protein and cluster: P51828

1 Blocks protein family: IPB009398 Adenylate cyclase-like

UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828

Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family

Similarity: Contains 2 guanylate cyclase domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADCY7_HUMAN, P51828

Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase

Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate

Genatlas biochemistry entry for ADCY7:

adenylyl cyclase,type VII

Enzyme Numbers (IUBMB): EC 4.6.1.1¹ ² EC 4.6.1²

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004016	adenylate cyclase activity	IDA	11113152
GO:0005524	ATP binding	IEA	--
GO:0016849	phosphorus-oxygen lyase activity	--	--
GO:0046872	metal ion binding	IEA	--

ADCY7 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for ADCY7:

Bright nuclei

Increased 8N DNA content

Increased cell number in G2M,

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adcy7):

behavior/neurological

mortality/aging

ADCY7 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Adcy7^tm1Btab for ADCY7

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADCY7

miRNA Products:		OriGene 3'-UTR Clone: ADCY7 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY7
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY7 (see all 19):
		hsa-miR-3200-5p hsa-miR-520f hsa-miR-4251 hsa-miR-1258 hsa-miR-128 hsa-miR-223 hsa-miR-3662 hsa-miR-3119

		SwitchGear 3'UTR luciferase reporter plasmid: ADCY7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY7 (see all 4) OriGene shRNA RFP: ADCY7 OriGene siRNA: ADCY7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY7
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADCY7

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ADCY7
			Sirion Biotech Customized adenovirus for overexpression of ADCY7 Sirion Biotech Customized adenovirus for potent knockdown of ADCY7

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADCY7 (NM_001114)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY7

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADCY7
		Search LifeMap BioReagents cell lines for ADCY7
		Sirion Biotech Customized stable knockdown cell line services for ADCY7 Sirion Biotech Customized inducible knockdown cell line services for ADCY7 Sirion Biotech Customized stable overexpressing cell line services for ADCY7 Sirion Biotech Customized inducible overexpressing cell line services for ADCY7

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY7

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/51 super-pathways (see all 51) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PKA activation in glucagon signalling

8/12 pathways (see all 12)
PKA activation in glucagon signalling	1.00	Neurophysiological process_PGE2-induced pain processing	0.44
PKA activation	0.94	Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling	0.37
PKA-mediated phosphorylation of CREB	0.89	Development_Role of Activin A in cell differentiation and proliferation	0.33
Regulation of CFTR gating (normal and CF)	0.76	Development Role of Activin A in cell differentiation and proliferation	0.33

DAG and IP3 signaling

DAG and IP3 signaling	1.00	CaM pathway	0.84
PLC-gamma1 signalling	0.94	Calmodulin induced events	0.84
EGFR interacts with phospholipase C-gamma	0.94	Ca-dependent events	0.79
PLCG1 events in ERBB2 signaling	0.91	Phospholipase C-mediated cascade	0.57

Regulation of Water Balance by Renal Aquaporins

Regulation of Water Balance by Renal Aquaporins	1.00	G alpha (z) signalling events	0.48
Aquaporin-mediated transport	0.84	Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation	0.40
Glucagon signaling in metabolic regulation	0.69	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation	0.40

Opioid Signalling

Opioid Signalling	1.00	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics	0.35
G-protein mediated events	0.55	Glutamatergic synapse	0.31
PLC beta mediated events	0.54

Pathway sources
See GeneCards unified pathways
Show all pathways

5/9 EMD Millipore Pathways for ADCY7 (see all 9)

	Adenylate cyclase-activating neuropeptides
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development Beta-adrenergic receptors signaling via cAMP
	Signal transduction cAMP signaling
	Signal transduction PKA signaling

5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY7 (see all 23)

	MAPK Signaling
	PKA Signaling
	Molecular Mechanisms of Cancer
	Relaxin Pathway
	G-AlphaI Signaling

5/12 GeneGo (Thomson Reuters) Pathways for ADCY7 (see all 12)

	Development Beta-adrenergic receptors signaling via cAMP
	Signal transduction cAMP signaling
	Signal transduction PKA signaling
	Development Endothelin-1/EDNRA signaling
	Regulation of CFTR activity (norm and CF)

5/7 BioSystems Pathways for ADCY7 (see all 7)

	G Protein Signaling Pathways
	Calcium Regulation in the Cardiac Cell
	Myometrial Relaxation and Contraction Pathways
	LPA4-mediated signaling events
	Regulation of Wnt-mediated beta catenin signaling and target gene transcription

5/50 Reactome Pathways for ADCY7 (see all 50)

	PKA activation
	Signaling by EGFR in Cancer
	G alpha (z) signalling events
	Downstream signal transduction
	Signal Transduction

2 PharmGKB Pathways for ADCY7

	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
	Proton Pump Inhibitor Pathway, Pharmacodynamics

5/16 Kegg Pathways (Kegg details for ADCY7) (see all 16):

	Purine metabolism
	Calcium signaling pathway
	Chemokine signaling pathway
	Oocyte meiosis
	Vascular smooth muscle contraction

ADCY7 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADCY7

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/302 Interacting proteins for ADCY7 (P51828³ ENSP00000254235⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 302)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRKCD	Q05655³, ENSP00000331602⁴	I2D: score=2 STRING: ENSP00000331602
ADCY1	ENSP00000297323⁴	STRING: ENSP00000297323
ADCY2	ENSP00000342952⁴	STRING: ENSP00000342952
ADCY4	ENSP00000312126⁴	STRING: ENSP00000312126
ADCY5	ENSP00000419361⁴	STRING: ENSP00000419361

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006171	cAMP biosynthetic process	--	--
GO:0006833	water transport	TAS	--
GO:0007165	signal transduction	TAS	--
GO:0007173	epidermal growth factor receptor signaling pathway	TAS	--

ADCY7 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADCY7 for compounds About GeneDecksing

EMD Millipore small molecules for ADCY7:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADCY7 available from Tocris Bioscience About this table

Compound	Action	CAS #
BPIPP	Non-competitive GC inhibitor. Also AC inhibitor	[325746-94-9]
NKH 477	Water-soluble adenylyl cyclase activator	[138605-00-2]
Forskolin	Adenylyl cyclase activator	[66575-29-9]
SQ 22536	Adenylyl cyclase inhibitor	[17318-31-9]
PACAP 1-38	Potent stimulator of adenylyl cyclase	--

10/11 HMDB Compounds for ADCY7 (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Cyclic GMP	3',5'-cyclic GMP (see all 13)	7665-99-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

3 Novoseek chemical compound relationships for ADCY7 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
forskolin	59.1	2	9751186 (1), 1648497 (1)
ionomycin	47.7	1	9751186 (1)
isoproterenol	34.2	1	1648497 (1)

Search CenterWatch for drugs/clinical trials and news about ADCY7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADCY7 gene:

NM_001114.3

Unigene Cluster for ADCY7:

Adenylate cyclase 7

Hs.513578 [show with all ESTs]

Unigene Representative Sequence: D25538

16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000564965 ENST00000564044 ENST00000394697(uc002egb.1 uc002egd.1)

ENST00000562623 ENST00000538642(uc002egc.2) ENST00000568933 ENST00000563677

ENST00000566761 ENST00000566433 ENST00000569265 ENST00000567277 ENST00000568731

ENST00000570187 ENST00000568930 ENST00000254235 ENST00000537579

miRNA Products:		OriGene 3'-UTR Clone: ADCY7 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY7
		8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY7 (see all 19):
		hsa-miR-3200-5p hsa-miR-520f hsa-miR-4251 hsa-miR-1258 hsa-miR-128 hsa-miR-223 hsa-miR-3662 hsa-miR-3119

		SwitchGear 3'UTR luciferase reporter plasmid: ADCY7 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY7 (see all 4) OriGene shRNA RFP: ADCY7 OriGene siRNA: ADCY7
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY7
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADCY7

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY7 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY7 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADCY7 (NM_001114)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY7
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY7

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY7 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADCY7
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY7
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY7

Additional cDNA sequence:

AK093706.1 BC039891.1 BC098566.1 BC126271.1 BC144120.1 D25538.1

12 DOTS entries:

DT.451853 DT.454106 DT.99999192 DT.101957054 DT.95232276 DT.120656745 DT.101978307 DT.451852

DT.75139342 DT.91826762 DT.92395375 DT.95191792

24/303 AceView cDNA sequences (see all 303):

AI950064 AA732013 BU622055 BU752339 BM984939 BC001611 BQ011423 BU620378

AI690000 AA961864 BQ775186 BM669874 BU631142 BQ011126 CA442476 AW004710

AF152604 AI304684 N25720 CR593793 BQ231832 AI433530 BG031737 AA235012

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY7 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20	^	21	^	22	^	23	^	24	^
SP1:																							-																				-
SP2:																							-
SP3:																					-		-		-		-		-
SP4:
SP5:

ExUns:	25	^	26	^	27	^	28
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for ADCY7

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADCY7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAAGTAACTA

About this image

ADCY7 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Extraembryonic Mesoderm

Extraembryonic Capillary Plexus

Extraembryonic Angioblasts

Endothelium

Testis

Seminiferous Tubules

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primordial germ cell-like cells (Reconstitution of mo...)

See ADCY7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCY7

SOURCE GeneReport for Unigene cluster: Hs.513578

SABiosciences Expression via Pathway-Focused PCR Arrays including ADCY7:

Primary Cilia in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ADCY7 gene from 6/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADCY7¹	adenylate cyclase 7	65.79(n) 71.6(a)		415732 XM_414097.3 XP_414097.3
lizard (Anolis carolinensis)	Reptilia	ADCY7⁶	--	64(a)	1 ↔ 1	GL343227.1(1708162-1766086)
African clawed frog (Xenopus laevis)	Amphibia	LOC399055²	type 7 adenylyl cyclase	71.6(n)		AY462195.1
zebrafish (Danio rerio)	Actinopterygii	adcy7¹	adenylate cyclase 7	61.5(n) 58.43(a)		568726 NM_001166272.1 NP_001159744.1
fruit fly (Drosophila melanogaster)	Insecta	Ac76E³	adenylate cyclase	38(a) (best of 3)		--
worm (Caenorhabditis elegans)	Secernentea	acy-4³ acy-2¹	Protein ACY-2¹	50(a) (best of 2)³ 45.32(n)¹ 40.6(a)¹		V(5627531-5629064)³ 191607¹ NM_072152.2¹ NP_504553.1¹

ENSEMBL Gene Tree for ADCY7 (if available)
TreeFam Gene Tree for ADCY7 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ADCY7 gene

ADCY5² ADCY2² GUCY2D² GUCY2C² NPR1² ADCY8² GUCY2F² GUCY1A2²

ADCY9² GUCY1B3² ADCY6² GUCY1A3² ADCY1² ADCY4² NPR2² ADCY3²

18/21 SIMAP similar genes for ADCY7 using alignment to 7 protein entries: ADCY7_HUMAN (see all proteins) (see all similar genes):

PAM16 MYCBPAP KIAA0586 L3MBTL2 DDX19A ETFA

TTC7A ADCY5 PSEN1 SYNE1 ADCY2 MRPS28

ADCY4 ADCY8 ADCY1 ADCY6 ADCY3 RHBDD3

ADCY7 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ADCY7
PGOHUM00000248360

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3760012^1,2	C,F,A,H	--	50319891(-)	`CCCACA/GCTTGC`	1	--	us2k¹		20		NS EA NA WA	2346
rs79514452^1,2		--	50319970(+)	`AAGCAC/TGGCTT`	1	--	us2k¹		0	--	--	--	--
rs140002773^1,2		--	50319976(+)	`GGCTTA/GCAGAC`	1	--	us2k¹		0	--	--	--	--
rs3892156^1,2	C,F,A,H	--	50319995(+)	`TTTGTG/ATCAGT`	1	--	us2k¹		34		NS EA NA WA CSA	3003
rs189873937^1,2		--	50320063(+)	`ACTTCA/GGAGGC`	1	--	us2k¹		0	--	--	--	--
rs3760011^1,2	C,F,A	--	50320200(-)	`AGGCTA/GAGGTG`	1	--	us2k¹		7		NA WA EA	366
rs115498275^1,2	F	--	50320230(+)	`AGCTAC/TGCAGG`	1	--	us2k¹		1		WA	118
rs12443620^1,2	H	--	50320314(+)	`ccagcC/Ttgggt`	1	--	us2k¹		0	--	--	--	--
rs12444236^1,2	H	--	50320441(+)	`GGGGCC/TTGAGC`	1	--	us2k¹		4		NS EA	420
rs143590894^1,2		--	50320456(+)	`GCCCCC/GCCACC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADCY7 (50280048 - 50352046 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADCY7: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ADCY7 for disorders           About GeneDecksing

OMIM gene information: 600385    OMIM disorders: --

13 diseases for ADCY7:    About MalaCards

precocious puberty thyroid adenoma chondrodysplasia adenoma

thyroiditis neuronitis cholera schizophrenia

immunodeficiency pancreatitis alcoholism colorectal cancer

breast cancer

1 disease from the University of Copenhagen DISEASES database for ADCY7:

Cholera

Human Genome Epidemiology (HuGE) Navigator: ADCY7 (4 documents)

Export disorders for ADCY7 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADCY7 gene, integrated from 9 sources (see all 46):
(articles sorted by number of sources associating them with ADCY7)

Utopia: connect your pdf to the dynamic
world of online information

Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. (PubMed id 7860067)^{1, 3, 9} Hellevuo K....Tabakoff B. (1995)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)^{1, 2} Nomura N.... Tabata S. (1994)
A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. (PubMed id 15581358)^{1, 9} Beeler J.A....Tang W.J. (2004)
Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. (PubMed id 12454008)^{1, 9} Nelson E.J....Tabakoff B. (2003)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Adenylate cyclase 7 is implicated in the biology of de pression and modulation of affective neural circuitry. (PubMed id 22264442)¹ Joeyen-Waldorf J....Sibille E. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Sex-specific role for adenylyl cyclase type 7 in alco hol dependence. (PubMed id 21481845)¹ DesriviA"res S....Tabakoff B. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 113	HGNC: 238	AceView: BRD7	Ensembl:ENSG00000121281	euGenes: HUgn113
ECgene: ADCY7	Kegg: 113	H-InvDB: ADCY7

(According to HUGE)
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HUGE: KIAA0037

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ADCY7	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ADCY7	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ADCY7 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADCY7 gene:
Search GeneIP for patents involving ADCY7

GeneCards and IP:
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adenylate cyclase 7

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ADCY7 Gene

adenylate cyclase 7

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