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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCY7 Gene

protein-coding   GIFtS: 67
GCID: GC16P050347

adenylate cyclase 7
 Explore 13 diseases affiliated with
ADCY7 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADCY7    

Aliases
for ADCY7 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adenylate Cyclase 71 2     ATP Pyrophosphate-Lyase 72 3
AC71 2     EC 4.6.1.13 8
KIAA00371 3     Adenylate Cyclase Type 72
Adenylate Cyclase Type VII2 3     EC 4.6.18
Adenylyl Cyclase 72 3     

External Ids:    HGNC: 2381   Entrez Gene: 1132   Ensembl: ENSG000001212817   OMIM: 6003855   UniProtKB: P518283   

Export aliases for ADCY7 gene to outside databases

Previous GC identifers: GC16P040735 GC16P050045 GC16P050099 GC16P048880 GC16P036209


Summaries
for ADCY7 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADCY7:
This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is
inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme
family that is characterized by the presence of twelve membrane-spanning domains in its sequences. (provided by
RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828
Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase

summary for ADCY7:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY7


Genomic Views
for ADCY7 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.1  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCY7 gene promoter:
         CREB   GR   deltaCREB   GR-beta   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADCY7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCY7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

ADCY7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P050347:  view genomic region     (about GC identifiers)

Start:
 50,280,048 bp from pter      End:
 50,352,046 bp from pter
Size:
 71,999 bases      Orientation:
 plus strand

Proteins
for ADCY7 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828 (See protein sequence)
Recommended Name: Adenylate cyclase type 7  
Size: 1080 amino acids; 120308 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA05021.2; Type=Erroneous initiation;
Secondary accessions: A0AVA6

Explore the universe of human proteins at neXtProt for ADCY7: NX_P51828

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51828

    • 4/16 DME Specific Peptides for ADCY7 (P51828) (see all 16)
     WQYDVWS  ASRMEST  EKIKTIG  GNVLCGV 

    ADCY7 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001105.1  
    ENSEMBL proteins: 
     ENSP00000460636   ENSP00000378187   ENSP00000445046   ENSP00000454301   ENSP00000457409  
     ENSP00000460018   ENSP00000455670   ENSP00000254235   ENSP00000437788  
    Reactome Protein details: P51828
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ADCY7
    OriGene Custom Protein Services for ADCY7 
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    Novus Biologicals ADCY7 Protein
    Novus Biologicals ADCY7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADCY7

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IDA11113152


    ADCY7 for ontologies           About GeneDecksing



    ADCY7 Antibody Products: 
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    Uscn Antibodies for ADCY7
    ThermoFisher Antibody for ADCY7

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    Uscn ELISAs and CLIAs for ADCY7

    Protein Domains /
    Families
    for ADCY7 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADCY7 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry P51828

    ProtoNet protein and cluster: P51828

    1 Blocks protein family: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    Function
    for ADCY7 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828
    Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate

         Genatlas biochemistry entry for ADCY7:
    adenylyl cyclase,type VII

    Enzyme Numbers (IUBMB): EC 4.6.1.11 2 EC 4.6.12

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY7
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY7 (see all 19):
    hsa-miR-3200-5p hsa-miR-520f hsa-miR-4251 hsa-miR-1258 hsa-miR-128 hsa-miR-223 hsa-miR-3662 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmid: ADCY7 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY7 (see all 4)
    OriGene shRNA RFP: ADCY7
    OriGene siRNA: ADCY7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY7

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ADCY7

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY7 (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ADCY7 (NM_001114)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY7 

    Cell Line
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    Search LifeMap BioReagents cell lines for ADCY7

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY7

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004016adenylate cyclase activity IDA11113152
    GO:0005524ATP binding IEA--
    GO:0016849phosphorus-oxygen lyase activity ----
    GO:0046872metal ion binding IEA--


    ADCY7 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ADCY7:
     Bright nuclei  Increased 8N DNA content  Increased cell number in G2M,  

    Animal Models:
         Mouse knock-out Adcy7tm1Btab for ADCY7
         2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adcy7):
     behavior/neurological  mortality/aging 

    ADCY7 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ADCY7 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/51 super-pathways (see all 51) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PKA activation in glucagon signalling
    8/12 pathways (see all 12)
    		PKA activation in glucagon signalling1.00
    		Neurophysiological process_PGE2-induced pain processing0.44
    		PKA activation0.94
    		Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.37
    		PKA-mediated phosphorylation of CREB0.89
    		Development_Role of Activin A in cell differentiation and proliferation0.33
    		Regulation of CFTR gating (normal and CF)0.76
    		Development Role of Activin A in cell differentiation and proliferation0.33
    3DAG and IP3 signaling
    		DAG and IP3 signaling1.00
    		CaM pathway0.84
    		PLC-gamma1 signalling0.94
    		Calmodulin induced events0.84
    		EGFR interacts with phospholipase C-gamma0.94
    		Ca-dependent events0.79
    		PLCG1 events in ERBB2 signaling0.91
    		Phospholipase C-mediated cascade0.57
    4Regulation of Water Balance by Renal Aquaporins
    		Regulation of Water Balance by Renal Aquaporins1.00
    		G alpha (z) signalling events0.48
    		Aquaporin-mediated transport0.84
    		Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation0.40
    		Glucagon signaling in metabolic regulation0.69
    		Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5Opioid Signalling
    		Opioid Signalling1.00
    		Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    		G-protein mediated events0.55
    		Glutamatergic synapse0.31
    		PLC beta mediated events0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/9 EMD Millipore Pathways for ADCY7 (see all 9)
        Adenylate cyclase-activating neuropeptides
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling

    5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY7 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    5/12 GeneGo (Thomson Reuters) Pathways for ADCY7 (see all 12)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    5/7 BioSystems Pathways for ADCY7 (see all 7) 
        G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways
    LPA4-mediated signaling events
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    5/50        Reactome Pathways for ADCY7 (see all 50)
        PKA activation
    Signaling by EGFR in Cancer
    G alpha (z) signalling events
    Downstream signal transduction
    Signal Transduction

    2 PharmGKB Pathways for ADCY7
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    5/16         Kegg Pathways  (Kegg details for ADCY7) (see all 16):
        Purine metabolism
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Vascular smooth muscle contraction


    ADCY7 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADCY7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/302 Interacting proteins for ADCY7 (P518283 ENSP000002542354) via UniProtKB, MINT, STRING, and/or I2D (see all 302)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process ----
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--


    ADCY7 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADCY7 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADCY7 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADCY7:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADCY7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BPIPPNon-competitive GC inhibitor. Also AC inhibitor[325746-94-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    ForskolinAdenylyl cyclase activator[66575-29-9]
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    PACAP 1-38Potent stimulator of adenylyl cyclase--

    10/11 HMDB Compounds for ADCY7 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    3 Novoseek chemical compound relationships for ADCY7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 59.1 2 9751186 (1), 1648497 (1)
    ionomycin 47.7 1 9751186 (1)
    isoproterenol 34.2 1 1648497 (1)

    Search CenterWatch for drugs/clinical trials and news about ADCY7 

    Transcripts
    for ADCY7 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADCY7 gene: 
    NM_001114.3  

    Unigene Cluster for ADCY7:

    Adenylate cyclase 7
    Hs.513578  [show with all ESTs]
    Unigene Representative Sequence: D25538
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564965 ENST00000564044 ENST00000394697(uc002egb.1 uc002egd.1)
    ENST00000562623 ENST00000538642(uc002egc.2) ENST00000568933 ENST00000563677
    ENST00000566761 ENST00000566433 ENST00000569265 ENST00000567277 ENST00000568731
    ENST00000570187 ENST00000568930 ENST00000254235 ENST00000537579

    miRNA
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    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY7 (see all 19):
    hsa-miR-3200-5p hsa-miR-520f hsa-miR-4251 hsa-miR-1258 hsa-miR-128 hsa-miR-223 hsa-miR-3662 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmid: ADCY7 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY7 (see all 4)
    OriGene shRNA RFP: ADCY7
    OriGene siRNA: ADCY7
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY7
    Clone
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    Primer
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    Additional cDNA sequence: 

    AK093706.1 BC039891.1 BC098566.1 BC126271.1 BC144120.1 D25538.1 

    12 DOTS entries:

    DT.451853  DT.454106  DT.99999192  DT.101957054  DT.95232276  DT.120656745  DT.101978307  DT.451852 
    DT.75139342  DT.91826762  DT.92395375  DT.95191792 

    24/303 AceView cDNA sequences (see all 303):

    AI950064 AA732013 BU622055 BU752339 BM984939 BC001611 BQ011423 BU620378 
    AI690000 AA961864 BQ775186 BM669874 BU631142 BQ011126 CA442476 AW004710 
    AF152604 AI304684 N25720 CR593793 BQ231832 AI433530 BG031737 AA235012 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                    -                                                           -                           
    SP2:                                                                    -                                                                                       
    SP3:                                                              -     -     -     -     -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ADCY7

    Expression
    for ADCY7 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCY7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CAAGTAACTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADCY7 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    TestisSeminiferous TubulesTestis
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Primordial germ cell-like cells (Reconstitution of mo...)

    See ADCY7 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCY7

    SOURCE GeneReport for Unigene cluster: Hs.513578
        SABiosciences Expression via Pathway-Focused PCR Arrays including ADCY7: 
              Primary Cilia in human mouse rat
              GABA & Glutamate in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for ADCY7 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADCY7 gene from 6/23 species (see all 23)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADCY71 adenylate cyclase 7 65.79(n)
    71.6(a)    		   415732  XM_414097.3  XP_414097.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ADCY76
    		 --
    		 64(a)
    		 1 ↔ 1
    		 GL343227.1(1708162-1766086)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3990552 type 7 adenylyl cyclase 71.6(n)    AY462195.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii adcy71 adenylate cyclase 7 61.5(n)
    58.43(a)    		   568726  NM_001166272.1  NP_001159744.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Ac76E3 adenylate cyclase 38(a)
    (best of 3)    		     --
    worm
    (Caenorhabditis elegans)    		 Secernentea acy-43
    acy-21    		 Protein ACY-21 50(a)
    (best of 2)3
    45.32(n)1
    40.6(a)1    		   V(5627531-5629064)3
    1916071  NM_072152.21  NP_504553.11 


    ENSEMBL Gene Tree for ADCY7 (if available)
    TreeFam Gene Tree for ADCY7 (if available) 

    Paralogs
    for ADCY7 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCY7 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY92  GUCY1B32  ADCY62  GUCY1A32  ADCY12  ADCY42  NPR22  ADCY32  
    18/21 SIMAP similar genes for ADCY7 using alignment to 7 protein entries:     ADCY7_HUMAN (see all proteins) (see all similar genes):
    PAM16    MYCBPAP    KIAA0586    L3MBTL2    DDX19A    ETFA
    TTC7A    ADCY5    PSEN1    SYNE1    ADCY2    MRPS28
    ADCY4    ADCY8    ADCY1    ADCY6    ADCY3    RHBDD3

    ADCY7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ADCY7
    PGOHUM00000248360


    Genomic Variants
    for ADCY7 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/766 NCBI SNPs in ADCY7 are shown (see all 766)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 16 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs37600121,2
    		C,F,A,H,--50319891(-) CCCACA/GCTTGC 1 -- us2k120Minor allele frequency- G:0.40NS EA NA WA 2346
    rs795144521,2
    		--50319970(+) AAGCAC/TGGCTT 1 -- us2k10--------
    rs1400027731,2
    		--50319976(+) GGCTTA/GCAGAC 1 -- us2k10--------
    rs38921561,2
    		C,F,A,H,--50319995(+) TTTGTG/ATCAGT 1 -- us2k134Minor allele frequency- A:0.46NS EA NA WA CSA 3003
    rs1898739371,2
    		--50320063(+) ACTTCA/GGAGGC 1 -- us2k10--------
    rs37600111,2
    		C,F,A,--50320200(-) AGGCTA/GAGGTG 1 -- us2k17Minor allele frequency- G:0.39NA WA EA 366
    rs1154982751,2
    		F,--50320230(+) AGCTAC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs124436201,2
    		H--50320314(+) ccagcC/Ttgggt 1 -- us2k10--------
    rs124442361,2
    		H--50320441(+) GGGGCC/TTGAGC 1 -- us2k14Minor allele frequency- T:0.00NS EA 420
    rs1435908941,2
    		--50320456(+) GCCCCC/GCCACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCY7 (50280048 - 50352046 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADCY7: --

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    Disorders / Diseases
    for ADCY7 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADCY7 for disorders           About GeneDecksing

    OMIM gene information: 600385    OMIM disorders: --

    13 diseases for ADCY7:    About MalaCards
    precocious puberty    thyroid adenoma    chondrodysplasia    adenoma
    thyroiditis    neuronitis    cholera    schizophrenia
    immunodeficiency    pancreatitis    alcoholism    colorectal cancer
    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ADCY7:
    Cholera
    Human Genome Epidemiology (HuGE) Navigator: ADCY7 (4 documents)

    Export disorders for ADCY7 gene to outside databases

    Publications
    for ADCY7 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCY7 gene, integrated from 9 sources (see all 46):
    (articles sorted by number of sources associating them with ADCY7)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. (PubMed id 7860067)1, 3, 9 Hellevuo K....Tabakoff B. (1995)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    4. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. (PubMed id 15581358)1, 9 Beeler J.A....Tang W.J. (2004)
    5. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. (PubMed id 12454008)1, 9 Nelson E.J....Tabakoff B. (2003)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Adenylate cyclase 7 is implicated in the biology of de pression and modulation of affective neural circuitry. (PubMed id 22264442)1 Joeyen-Waldorf J....Sibille E. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Sex-specific role for adenylyl cyclase type 7 in alco hol dependence. (PubMed id 21481845)1 DesriviA"res S....Tabakoff B. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for ADCY7 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ADCY7 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113 HGNC: 238 AceView: BRD7 Ensembl:ENSG00000121281 euGenes: HUgn113
    ECgene: ADCY7 Kegg: 113 H-InvDB: ADCY7

    Other Databases showing ADCY7 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0037

    Specialized Databases showing ADCY7 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCY7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADCY7 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADCY7 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADCY7 gene:
    Search GeneIP for patents involving ADCY7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

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