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ADCY7 Gene

protein-coding   GIFtS: 71
GCID: GC16P050280

Adenylate Cyclase 7

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase 71 2     AC72
Adenylate Cyclase Type VII2 3     Adenylate Cyclase Type 72
Adenylyl Cyclase 72 3     KIAA00373
ATP Pyrophosphate-Lyase 72 3     EC 4.6.18
EC 4.6.1.13 8     

External Ids:    HGNC: 2381   Entrez Gene: 1132   Ensembl: ENSG000001212817   OMIM: 6003855   UniProtKB: P518283   

Export aliases for ADCY7 gene to outside databases

Previous GC identifers: GC16P040735 GC16P050347 GC16P050045 GC16P050099 GC16P048880 GC16P036209


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCY7 Gene:
This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is
inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase
enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several
transcript variants have been observed for this gene, but the full-length natures of only two have been
determined so far. (provided by RefSeq, Oct 2013)

GeneCards Summary for ADCY7 Gene:
ADCY7 (adenylate cyclase 7) is a protein-coding gene. Diseases associated with ADCY7 include precocious puberty, and thyroid adenoma. GO annotations related to this gene include adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828
Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase

summary for ADCY7 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCY7 gene promoter:
         CREB   GR   deltaCREB   GR-beta   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCY7 promoter sequence
   Search Chromatin IP Primers for ADCY7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCY7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.1   Ensembl cytogenetic band:  16q12.1   HGNC cytogenetic band: 16q12.1

ADCY7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY7 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P050280:  view genomic region     (about GC identifiers)

Start:
50,280,048 bp from pter      End:
50,352,046 bp from pter
Size:
71,999 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828 (See protein sequence)
Recommended Name: Adenylate cyclase type 7  
Size: 1080 amino acids; 120308 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Sequence caution: Sequence=BAA05021.2; Type=Erroneous initiation;
Secondary accessions: A0AVA6

Explore the universe of human proteins at neXtProt for ADCY7: NX_P51828

Explore proteomics data for ADCY7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys273, Lys443, Lys579, Lys1006, Lys1073
  • Glycosylation2 at Asn701, Asn776, Asn781
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADCY7 (P51828) (see all 16)
     WQYDVWS  ASRMEST  EKIKTIG  GNVLCGV 


    See ADCY7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001105.1  NP_001272986.1  

    ENSEMBL proteins: 
     ENSP00000460636   ENSP00000378187   ENSP00000457409   ENSP00000454301   ENSP00000460018  
     ENSP00000455670   ENSP00000254235   ENSP00000445046   ENSP00000437788  
    Reactome Protein details: P51828

    ADCY7 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ADCY7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADCY7
    GenScript Custom Purified and Recombinant Proteins Services for ADCY7
    Novus Biologicals ADCY7 Protein
    Novus Biologicals ADCY7 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY7

    ADCY7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals ADCY7 Antibodies
    Abcam antibodies for ADCY7
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    ThermoFisher Antibody for ADCY7
    LSBio Antibodies in human, mouse, rat for ADCY7

    ADCY7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ADCY7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADCY7
    Cloud-Clone Corp. CLIAs for ADCY7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC7
    Adenylyl cyclases

    3 InterPro protein domains:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry P51828

    ProtoNet protein and cluster: P51828

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY7_HUMAN, P51828
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY7_HUMAN, P51828
    Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate

         Genatlas biochemistry entry for ADCY7:
    adenylyl cyclase,type VII

         Enzyme Numbers (IUBMB): EC 4.6.1.11 2 EC 4.6.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004016adenylate cyclase activity IDA11113152
    GO:0005524ATP binding IEA--
    GO:0016849phosphorus-oxygen lyase activity ----
    GO:0046872metal ion binding IEA--
         
    ADCY7 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ADCY7:
     Bright nuclei  Increased 8N DNA content  Increased cell number in G2M,  

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adcy7):
     behavior/neurological  digestive/alimentary  immune system  mortality/aging 

    ADCY7 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adcy7tm1Btab for ADCY7

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADCY7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADCY7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY7

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADCY7:
    hsa-mir-335-5p (MIRT018909)

    Block miRNA regulation of human, mouse, rat ADCY7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADCY7 (see all 19):
    hsa-miR-3200-5p hsa-miR-520f hsa-miR-4251 hsa-miR-1258 hsa-miR-128 hsa-miR-223 hsa-miR-3662 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidADCY7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADCY7
    Predesigned siRNA for gene silencing in human, mouse, rat ADCY7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADCY7

    Clone
    Products:
         
    OriGene clones in human, mouse for ADCY7 (see all 7)
    OriGene ORF clones in mouse, rat for ADCY7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY7 (NM_001114)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY7

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ADCY7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADCY7_HUMAN, P51828: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IDA11113152

    ADCY7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCY7 About   (see all 55)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Adenylate cyclase inhibitory pathway
    Adenylate cyclase inhibitory pathway0.53
    Inhibition of adenylate cyclase pathway0.00
    LPA4-mediated signaling events0.53
    Adenylate cyclase activating pathway0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADCY7 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ADCY7 (see all 12)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    Selected BioSystems Pathways for ADCY7 (see all 7)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events
    Endothelins

    Selected Reactome Pathways for ADCY7 (see all 9)
        PKA activation
    PKA activation in glucagon signalling
    G alpha (z) signalling events
    Adenylate cyclase inhibitory pathway
    Glucagon signaling in metabolic regulation

    2 PharmGKB Pathways for ADCY7
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADCY7) (see all 29):
        Purine metabolism
    Rap1 signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis


    ADCY7 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADCY7: 
              Primary Cilia in human mouse rat
              GABA & Glutamate in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADCY7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCY7 (P518283 ENSP000002542354) via UniProtKB, MINT, STRING, and/or I2D (see all 310)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCDQ056553, ENSP000003316024I2D: score=2 STRING: ENSP00000331602
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADCY9ENSP000002940164STRING: ENSP00000294016
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process ----
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    ADCY7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADCY7 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    Selected HMDB Compounds for ADCY7 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    3 Novoseek inferred chemical compound relationships for ADCY7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 59.1 2 9751186 (1), 1648497 (1)
    ionomycin 47.7 1 9751186 (1)
    isoproterenol 34.2 1 1648497 (1)



    ADCY7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADCY7 gene (2 alternative transcripts): 
    NM_001114.4  NM_001286057.1  

    Unigene Cluster for ADCY7:

    Adenylate cyclase 7
    Hs.513578  [show with all ESTs]
    Unigene Representative Sequence: D25538
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564965 ENST00000564044 ENST00000394697(uc002egb.1 uc002egd.1)
    ENST00000562623 ENST00000566433 ENST00000568933 ENST00000563677 ENST00000566761
    ENST00000569265 ENST00000567277 ENST00000568731 ENST00000570187 ENST00000568930
    ENST00000254235 ENST00000538642(uc002egc.2) ENST00000537579
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADCY7 (see all 19):
    hsa-miR-3200-5p hsa-miR-520f hsa-miR-4251 hsa-miR-1258 hsa-miR-128 hsa-miR-223 hsa-miR-3662 hsa-miR-3119
    SwitchGear 3'UTR luciferase reporter plasmidADCY7 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADCY7
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY7 (NM_001114)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADCY7
      QuantiTect SYBR Green Assays in human, mouse, rat ADCY7
      QuantiFast Probe-based Assays in human, mouse, rat ADCY7

    Additional mRNA sequence: 

    AK093706.1 BC039891.1 BC098566.1 BC126271.1 BC144120.1 D25538.1 

    12 DOTS entries:

    DT.451853  DT.454106  DT.99999192  DT.101957054  DT.95232276  DT.120656745  DT.101978307  DT.451852 
    DT.75139342  DT.91826762  DT.92395375  DT.95191792 

    Selected AceView cDNA sequences (see all 303):

    BU622055 N43948 BU186343 AA732013 AA904242 AA292166 BC050728 BM669874 
    CA442476 AA961864 AA292066 BC001611 BE378599 BQ011126 AA353892 AI571814 
    BM984939 AW004710 BU686027 AI080665 AI358382 CA312534 BM663726 AI191240 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY7    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                    -                                                           -                           
    SP2:                                                                    -                                                                                       
    SP3:                                                              -     -     -     -     -                                                                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 25 ^ 26 ^ 27 ^ 28
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ADCY7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADCY7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAAGTAACTA
    ADCY7 Expression
    About this image


    ADCY7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 2 entries
             T-Cytotoxic Cells Thymus
             Thymus
     
     Testis (Reproductive System)
             Seminiferous Tubules
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Gonad
             Primordial germ cell-like cells
     
     Germ Cells (Reproductive System)
             Primordial germ cell-like cells
    ADCY7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCY7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513578
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADCY7: 
              Primary Cilia in human mouse rat
              GABA & Glutamate in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADCY7 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy71 , 5 adenylate cyclase 71, 5 83.04(n)1
    84.44(a)1
      8 (43.06 cM)5
    115131  NM_007406.21  NP_031432.21 
     882724035 
    chicken
    (Gallus gallus)
    Aves ADCY71 adenylate cyclase 7 64.62(n)
    69.78(a)
      415732  XM_414097.4  XP_414097.4 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY76
    adenylate cyclase 7
    65(a)
    1 ↔ 1
    GL343227.1(1708445-1812981)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3990552 type 7 adenylyl cyclase 71.6(n)    AY462195.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adcy71 adenylate cyclase 7 61.37(n)
    58.24(a)
      568726  NM_001166272.1  NP_001159744.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ac76E3 adenylate cyclase 38(a)
    (best of 3)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea acy-43   -- 50(a)
    (best of 2)
      V(5627531-5629064)   --


    ENSEMBL Gene Tree for ADCY7 (if available)
    TreeFam Gene Tree for ADCY7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADCY7 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    Selected SIMAP similar genes for ADCY7 using alignment to 7 protein entries:     ADCY7_HUMAN (see all proteins) (see all similar genes):
    PAM16    MYCBPAP    KIAA0586    L3MBTL2    DDX19A    ETFA
    ADCY9    TTC7A    ADCY5    PSEN1    SYNE1    ADCY2
    MRPS28    ADCY4    ADCY8    ADCY1    ADCY6    RHBDD3

    ADCY7 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ADCY7
    PGOHUM00000248360


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADCY7 (see all 1074)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37600121,2
    C,F,A,H--50319891(-) CCCACA/GCTTGC 1 -- us2k120Minor allele frequency- G:0.40NS EA NA WA 2346
    rs795144521,2
    C--50319970(+) AAGCAC/TGGCTT 1 -- us2k10--------
    rs1400027731,2
    --50319976(+) GGCTTA/GCAGAC 1 -- us2k10--------
    rs38921561,2
    C,F,A,H--50319995(+) TTTGTG/ATCAGT 1 -- us2k134Minor allele frequency- A:0.46NS EA NA WA CSA 3003
    rs1898739371,2
    --50320063(+) ACTTCA/GGAGGC 1 -- us2k10--------
    rs37600111,2
    C,F,A--50320200(-) AGGCTA/GAGGTG 1 -- us2k17Minor allele frequency- G:0.39NA WA EA 366
    rs1154982751,2
    F--50320230(+) AGCTAC/TGCAGG 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs124436201,2
    H--50320314(+) ccagcC/Ttgggt 1 -- us2k10--------
    rs346860941,2
    C--50320340(+) ATCTC-/AAAAAA 1 -- us2k10--------
    rs3710184861,2
    C--50320340(+) CATCTA/CAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCY7 (50280048 - 50352046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ADCY7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906662CNV Loss21882294
    nsv1805CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADCY7
    DNA2.0 Custom Variant and Variant Library Synthesis for ADCY7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600385    OMIM disorders: --

    16 diseases for ADCY7:    
    About MalaCards
    precocious puberty    thyroid adenoma    adenoma    chondrodysplasia
    thyroiditis    dilated cardiomyopathy    cholera    alcohol dependence
    inflammatory bowel disease    schizophrenia    asthma    colorectal cancer
    neuronitis    hiv-1    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ADCY7:
    Cholera

    ADCY7 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADCY7
    Human Genome Epidemiology (HuGE) Navigator: ADCY7 (4 documents)

    Export disorders for ADCY7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADCY7 gene, integrated from 10 sources (see all 51):
    (articles sorted by number of sources associating them with ADCY7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. (PubMed id 7860067)1, 3, 9 Hellevuo K....Tabakoff B. (Hum. Genet. 1995)
    2. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    5. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. (PubMed id 15581358)1, 9 Beeler J.A....Tang W.J. (Biochemistry 2004)
    6. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. (PubMed id 12454008)1, 9 Nelson E.J....Tabakoff B. (J. Biol. Chem. 2003)
    7. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    10. Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry. (PubMed id 22264442)1 Joeyen-Waldorf J....Sibille E. (Biol. Psychiatry 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 113 HGNC: 238 AceView: BRD7 Ensembl:ENSG00000121281 euGenes: HUgn113
    ECgene: ADCY7 Kegg: 113 H-InvDB: ADCY7

    (According to HUGE)
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    HUGE: KIAA0037

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADCY7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADCY7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADCY7 gene:
    Search GeneIP for patents involving ADCY7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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