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Aliases for ADCY7 Gene

Aliases for ADCY7 Gene

  • Adenylate Cyclase 7 2 3
  • Adenylate Cyclase Type VII 3 4
  • ATP Pyrophosphate-Lyase 7 3 4
  • Adenylyl Cyclase 7 3 4
  • EC 4 63
  • Adenylate Cyclase Type 7 3
  • KIAA0037 4
  • EC 4.6.1 63
  • AC7 3

External Ids for ADCY7 Gene

Previous GeneCards Identifiers for ADCY7 Gene

  • GC16P040735
  • GC16P050347
  • GC16P050045
  • GC16P050099
  • GC16P048880
  • GC16P036209
  • GC16P050280

Summaries for ADCY7 Gene

Entrez Gene Summary for ADCY7 Gene

  • This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

GeneCards Summary for ADCY7 Gene

ADCY7 (Adenylate Cyclase 7) is a Protein Coding gene. Diseases associated with ADCY7 include adenoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY7 Gene

  • This is a membrane-bound, calcium-inhibitable adenylyl cyclase

Tocris Summary for ADCY7 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY7 Gene

Genomics for ADCY7 Gene

Regulatory Elements for ADCY7 Gene

Genomic Location for ADCY7 Gene

50,244,919 bp from pter
50,318,135 bp from pter
73,217 bases
Plus strand

Genomic View for ADCY7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY7 Gene

Proteins for ADCY7 Gene

  • Protein details for ADCY7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenylate cyclase type 7
    Protein Accession:
    Secondary Accessions:
    • A0AVA6

    Protein attributes for ADCY7 Gene

    1080 amino acids
    Molecular mass:
    120308 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    No Data Available
    • Sequence=BAA05021.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADCY7 Gene

Proteomics data for ADCY7 Gene at MOPED

Post-translational modifications for ADCY7 Gene

  • Ubiquitination at Lys273, Lys443, Lys579, Lys1006, and Lys1073
  • Glycosylation at Asn701, Asn776, and Asn781
  • Modification sites at PhosphoSitePlus

Other Protein References for ADCY7 Gene

Antibody Products

Domains for ADCY7 Gene

Gene Families for ADCY7 Gene

Protein Domains for ADCY7 Gene

Suggested Antigen Peptide Sequences for ADCY7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY7: view

Function for ADCY7 Gene

Molecular function for ADCY7 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type VII
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

Enzyme Numbers (IUBMB) for ADCY7 Gene

Gene Ontology (GO) - Molecular Function for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IDA 11113152
GO:0005524 ATP binding IEA --
GO:0016849 phosphorus-oxygen lyase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADCY7: view
genes like me logo Genes that share phenotypes with ADCY7: view

Animal Models for ADCY7 Gene

MGI Knock Outs for ADCY7:

miRNA for ADCY7 Gene

miRTarBase miRNAs that target ADCY7

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY7

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ADCY7 Gene

Localization for ADCY7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY7 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADCY7 Gene COMPARTMENTS Subcellular localization image for ADCY7 gene
Compartment Confidence
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IDA 11113152
genes like me logo Genes that share ontologies with ADCY7: view

Pathways for ADCY7 Gene

SuperPathways for ADCY7 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADCY7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process IEA --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY7: view

Drugs for ADCY7 Gene

(5) Tocris Compounds for ADCY7 Gene

Compound Action Cas Number
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
PACAP 1-38 Potent stimulator of adenylyl cyclase [137061-48-4]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(11) HMDB Compounds for ADCY7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Ca
Cyclic AMP
  • 3'5'-Cyclic AMP
Cyclic GMP
  • 3',5'-Cyclic GMP
Guanosine triphosphate
  • 5'-GTP

(3) Novoseek inferred chemical compound relationships for ADCY7 Gene

Compound -log(P) Hits PubMed IDs
forskolin 59.1 2
ionomycin 47.7 1
isoproterenol 34.2 1
genes like me logo Genes that share compounds with ADCY7: view

Transcripts for ADCY7 Gene

Unigene Clusters for ADCY7 Gene

Adenylate cyclase 7:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY7 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - -
SP2: -
SP3: - - - - -

ExUns: 25 ^ 26 ^ 27 ^ 28

Relevant External Links for ADCY7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCY7 Gene

mRNA expression in normal human tissues for ADCY7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY7 Gene

This gene is overexpressed in Whole Blood (6.5).

Protein differential expression in normal tissues for ADCY7 Gene

This gene is overexpressed in Monocytes (27.6), Peripheral blood mononuclear cells (12.2), Placenta (11.3), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADCY7 Gene

SOURCE GeneReport for Unigene cluster for ADCY7 Gene Hs.513578

genes like me logo Genes that share expressions with ADCY7: view

Expression partners for ADCY7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADCY7 Gene

Orthologs for ADCY7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCY7 35
  • 85.92 (n)
  • 86.42 (a)
ADCY7 36
  • 85 (a)
(Canis familiaris)
Mammalia ADCY7 35
  • 85.66 (n)
  • 86.41 (a)
ADCY7 36
  • 85 (a)
(Mus musculus)
Mammalia Adcy7 35
  • 83.04 (n)
  • 84.44 (a)
Adcy7 16
Adcy7 36
  • 83 (a)
(Pan troglodytes)
Mammalia ADCY7 35
  • 98.37 (n)
  • 98.34 (a)
ADCY7 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Adcy7 35
  • 83.38 (n)
  • 84.72 (a)
(Monodelphis domestica)
Mammalia ADCY7 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ADCY7 36
  • 80 (a)
(Gallus gallus)
Aves ADCY7 35
  • 64.62 (n)
  • 69.78 (a)
ADCY7 36
  • 68 (a)
(Anolis carolinensis)
Reptilia ADCY7 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy7 35
  • 61.75 (n)
  • 64.22 (a)
Str.13076 35
African clawed frog
(Xenopus laevis)
Amphibia LOC399055 35
(Danio rerio)
Actinopterygii adcy7 35
  • 61.37 (n)
  • 58.24 (a)
adcy7 36
  • 56 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 37
  • 38 (a)
  • 27 (a)
  • 28 (a)
Ac76E 36
  • 32 (a)
(Caenorhabditis elegans)
Secernentea acy-2 37
  • 41 (a)
acy-4 37
  • 50 (a)
acy-2 36
  • 29 (a)
Species with no ortholog for ADCY7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY7 Gene

Gene Tree for ADCY7 (if available)
Gene Tree for ADCY7 (if available)

Paralogs for ADCY7 Gene Pseudogenes for ADCY7 Gene

genes like me logo Genes that share paralogs with ADCY7: view

Variants for ADCY7 Gene

Sequence variations from dbSNP and Humsavar for ADCY7 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs75816088 -- 50,314,006(+) CCATC(A/G)GCAGC missense, reference
rs75831772 -- 50,316,117(+) ATACA(C/T)TAATG utr-variant-3-prime
rs75745969 -- 50,311,799(+) GGCTG(C/G)CCCCC intron-variant
rs75745733 -- 50,276,959(+) TTTTT(G/T)AGTCA intron-variant
rs75670870 -- 50,312,209(+) GGGGC(-/TGGGGC)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY7 Gene

Variant ID Type Subtype PubMed ID
nsv906662 CNV Loss 21882294
nsv1805 CNV Loss 18451855

Relevant External Links for ADCY7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY7 Gene

Disorders for ADCY7 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADCY7 Gene in MalaCards »

(1) Disease for ADCY7 Gene

(1) University of Copenhagen DISEASES for ADCY7 Gene

Relevant External Links for ADCY7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADCY7: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ADCY7 Gene

Publications for ADCY7 Gene

  1. Localization of the gene for a novel human adenylyl cyclase (ADCY7) to chromosome 16. (PMID: 7860067) Hellevuo K. … Tabakoff B. (Hum. Genet. 1995) 2 3 23
  2. Ethanol-induced phosphorylation and potentiation of the activity of type 7 adenylyl cyclase. Involvement of protein kinase C delta. (PMID: 12454008) Nelson E.J. … Tabakoff B. (J. Biol. Chem. 2003) 3 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A soluble C1b protein and its regulation of soluble type 7 adenylyl cyclase. (PMID: 15581358) Beeler J.A. … Tang W.J. (Biochemistry 2004) 3 23
  5. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PMID: 7584026) Nomura N. … Tabata S. (DNA Res. 1994) 3 4

Products for ADCY7 Gene

Sources for ADCY7 Gene

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