ADCY6 Gene
protein-coding GIFtS: 69
GCID: GC12M049159
|
|
adenylate cyclase 6
| |
Aliases
for ADCY6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenylate Cyclase 61 2 | | ATP Pyrophosphate-Lyase 62 3 | | AC61 2 | | EC 4.6.1.13 8 | | Adenylate Cyclase Type VI2 3 | | Adenylate Cyclase Type 62 | | Adenylyl Cyclase 62 3 | | KIAA04223 | | Ca(2+)-Inhibitable Adenylyl Cyclase2 3 | | |
Export aliases for ADCY6 gene to outside databasesPrevious GC identifers: GC12P061214 GC12M049170 GC12M048876 GC12M047446 GC12M046193 |
Summaries
for ADCY6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADCY6:
This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of thesecondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid andbrain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroidtumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)
 summary
for ADCY6: Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.
Gene Wiki entry for ADCY6
|
Genomic Views
for ADCY6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADCY6 gene promoter:
MZF-1 Sp1 HNF-1 Pax-2 Pax-2a HNF-1A
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADCY6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q12-q13 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q12-q13ADCY6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M049159: view genomic region
(about GC identifiers)
Start:
|
49,159,975 bp from pter |
End:
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49,182,820 bp from pter |
Size:
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22,846 bases |
Orientation:
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minus strand |
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Proteins
for ADCY6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306 (See
protein sequence)Recommended Name: Adenylate cyclase type 6 Size: 1168 amino acids; 130615 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subunit: Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity)
Sequence caution: Sequence=BAA24852.2; Type=Erroneous initiation;
Secondary accessions: Q9NR75 Q9UDB0Alternative splicing: 2 isoforms: O43306-1 O43306-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ADCY6: NX_O43306
Post-translational modifications:
Phosphorylated by RAF11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O43306
4/35 DME Specific Peptides for ADCY6 (O43306) (see all 35)
ADCY6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_056085.1 NP_066193.1
ENSEMBL proteins: ENSP00000446730 ENSP00000311405 ENSP00000447702 ENSP00000350536 Reactome Protein details: O43306
Human Recombinant Protein Products:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
ADCY6 for ontologies About GeneDecksing
ADCY6 Antibody Products:
Assay Products for ADCY6: |
Protein
Domains /
Families
for ADCY6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADCY6 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43306ProtoNet protein and cluster: O43306 1 Blocks protein family: IPB009398 Adenylate cyclase-like
UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase familySimilarity: Contains 2 guanylate cyclase domains |
Function
for ADCY6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphateEnzyme regulation: Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation byRAF1 results in its activation Genatlas biochemistry entry for ADCY6:adenylyl cyclase,type VI,ubiquitous
Enzyme Number (IUBMB): EC 4.6.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ADCY6 (NM_020983) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCY6 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY6 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
ADCY6 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ADCY6:
Animal Models:
Mouse knock-outs for ADCY6: Adcy6tm2Yich Adcy6tm1Hkh
5 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Adcy6):
ADCY6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADCY6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/53 super-pathways (see all 53) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PKA activation in glucagon signalling | | | 3 | DAG and IP3 signaling | | | 4 | Regulation of Water Balance by Renal Aquaporins | | | 5 | Opioid Signalling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/10 EMD Millipore Pathways for ADCY6 (see all 10)
5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY6 (see all 23)
5/13  GeneGo (Thomson Reuters) Pathways for ADCY6 (see all 13)
5/6  BioSystems Pathways for ADCY6 (see all 6)
5/53 
Reactome Pathways for ADCY6 (see all 53)
2  PharmGKB Pathways for ADCY6
5/18 
Kegg Pathways (Kegg details for ADCY6) (see all 18):
ADCY6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/298 Interacting proteins for ADCY6 (O433062, 3 ENSP000003114054) via UniProtKB, MINT, STRING, and/or I2D (see all 298)About this table
Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table
ADCY6 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADCY6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADCY6 for compounds About GeneDecksing
Compounds for ADCY6 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| BPIPP | Non-competitive GC inhibitor. Also AC inhibitor | [325746-94-9] | | NKH 477 | Water-soluble adenylyl cyclase activator | [138605-00-2] | | Forskolin | Adenylyl cyclase activator | [66575-29-9] | | SQ 22536 | Adenylyl cyclase inhibitor | [17318-31-9] | | PACAP 1-38 | Potent stimulator of adenylyl cyclase | -- |
10/11 HMDB Compounds for ADCY6 (see all 11) About this table
2 Novoseek chemical compound relationships for ADCY6 gene About this table
Search CenterWatch for drugs/clinical trials and news about ADCY6
|
Transcripts
for ADCY6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADCY6 gene (2 alternative transcripts): NM_015270.3 NM_020983.2 Unigene Clusters for ADCY6: Adenylate cyclase 6 Hs.525401 [show with all ESTs], Hs.694408 [show with all ESTs]Unigene Representative Sequences: NM_015270, AK2252249 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000547260(uc010slw.1) ENST00000550422(uc001rsi.4 uc001rsj.4)
ENST00000307885(uc001rsh.4) ENST00000552099 ENST00000548351 ENST00000552090
ENST00000551435 ENST00000548820 ENST00000357869
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY6 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ADCY6 (NM_020983) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCY6 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY6 |
Additional cDNA sequence: AK225224.1 11 DOTS entries: DT.99937161 DT.40108164 DT.91743387 DT.453565 DT.95333624 DT.100777803 DT.100730796 DT.100027161 DT.100777796 DT.102831861 DT.75111797 7 AceView cDNA sequences: U65474 AB007882 BX537664 NM_020983 NM_015270 AF250226 BC064923
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY6 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ADCY6
|
Expression
for ADCY6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADCY6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGATGAAAG
About this image
See ADCY6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCY6
SOURCE GeneReport for Unigene clusters: Hs.525401 Hs.694408
SABiosciences Custom PCR Arrays for ADCY6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCY6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY6 |
Orthologs
for ADCY6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADCY6 gene from 4/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
ADCY66 |
-- |
77(a) |
1 ↔ 1 |
2(94460752-94526698) |
zebrafish
(Danio rerio) |
Actinopterygii |
adcy6b1 |
adenylate cyclase 6b |
70.88(n)
74.89(a) |
|
560807 XM_002666490.1 XP_002666536.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
rut3 |
molting cycle (sensu Insecta) adenylate
cyclase |
49(a)
(best of 5) |
|
12F4 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
acy-43 |
-- |
49(a)
(best of 2) |
|
V(5627531-5629064) -- |
ENSEMBL Gene Tree for ADCY6 (if available)
TreeFam Gene Tree for ADCY6 (if available) |
Paralogs
for ADCY6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADCY6 gene
- ADCY52 ADCY22 GUCY2D2 GUCY2C2 NPR12 ADCY82 GUCY2F2 GUCY1A22
- ADCY72 ADCY92 GUCY1B32 GUCY1A32 ADCY12 ADCY42 NPR22 ADCY32
7 SIMAP similar genes for ADCY6 using alignment to 2 protein entries: ADCY6_HUMAN (see all proteins):ADCY5 ADCY1 ADCY3 ADCY2 ADCY4 ADCY8
ADCY7
ADCY6 for paralogs About GeneDecksing
|
Genomic Variants
for ADCY6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
|
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