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ADCY6 Gene

protein-coding   GIFtS: 73
GCID: GC12M049159

Adenylate Cyclase 6

  See ADCY6-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase 61 2     EC 4.6.1.13 8
Adenylate Cyclase Type VI2 3     AC62
Adenylyl Cyclase 62 3     Adenylate Cyclase Type 62
Ca(2+)-Inhibitable Adenylyl Cyclase2 3     KIAA04223
ATP Pyrophosphate-Lyase 62 3     

External Ids:    HGNC: 2371   Entrez Gene: 1122   Ensembl: ENSG000001742337   OMIM: 6002945   UniProtKB: O433063   

Export aliases for ADCY6 gene to outside databases

Previous GC identifers: GC12P061214 GC12M049170 GC12M048876 GC12M047446 GC12M046193


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCY6 Gene:
This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the
secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid
and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning
thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ADCY6 Gene:
ADCY6 (adenylate cyclase 6) is a protein-coding gene. Diseases associated with ADCY6 include hypomyelination neuropathy - arthrogryposis, and thyroid adenoma. GO annotations related to this gene include adenylate cyclase activity and protein kinase binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306
Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)

summary for ADCY6 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCY6 gene promoter:
         MZF-1   Sp1   HNF-1   Pax-2   Pax-2a   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCY6 promoter sequence
   Search Chromatin IP Primers for ADCY6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCY6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12-q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q12-q13

ADCY6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049159:  view genomic region     (about GC identifiers)

Start:
49,159,975 bp from pter      End:
49,182,820 bp from pter
Size:
22,846 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306 (See protein sequence)
Recommended Name: Adenylate cyclase type 6  
Size: 1168 amino acids; 130615 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subunit: Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1
Sequence caution: Sequence=BAA24852.2; Type=Erroneous initiation;
Secondary accessions: Q9NR75 Q9UDB0
Alternative splicing: 2 isoforms:  O43306-1   O43306-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADCY6: NX_O43306

Explore proteomics data for ADCY6 at MOPED

Post-translational modifications: 

  • Phosphorylated by RAF11
  • Ubiquitination2 at Lys129
  • Glycosylation2 at Asn793
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADCY6 (O43306) (see all 35)
     AGRIHIT  EKIKTIG  FHKIYIQ  IETFLIL 


    See ADCY6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056085.1  NP_066193.1  

    ENSEMBL proteins: 
     ENSP00000446730   ENSP00000311405   ENSP00000447702   ENSP00000350536  
    Reactome Protein details: O43306

    ADCY6 Human Recombinant Protein Products:

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    Novus Biologicals ADCY6 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY6

     
    Search eBioscience for Proteins for ADCY6 

     
    antibodies-online proteins for ADCY6 (5 products) 

     
    antibodies-online peptides for ADCY6

    ADCY6 Antibody Products:

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    antibodies-online antibodies for ADCY6 (37 products) 

    ADCY6 Assay Products:

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    Cloud-Clone Corp. ELISAs for ADCY6
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    antibodies-online kits for ADCY6 (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC6
    Adenylyl cyclases

    3 InterPro protein domains:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry O43306

    ProtoNet protein and cluster: O43306

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    Find genes that share domains with ADCY6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY6_HUMAN, O43306
    Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation
    by RAF1 results in its activation

         Genatlas biochemistry entry for ADCY6:
    adenylyl cyclase,type VI,ubiquitous

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004016adenylate cyclase activity IDA18403039
    GO:0005515protein binding IPI17081159
    GO:0005524ATP binding IEA--
    GO:0016849phosphorus-oxygen lyase activity ----
    GO:0019901protein kinase binding ISS--
         
    Find genes that share ontologies with ADCY6           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADCY6:
     G0/1 arrest  Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adcy6):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  muscle  renal/urinary system 

    Find genes that share phenotypes with ADCY6           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADCY6: Adcy6tm2Yich Adcy6tm1Hkh

       genOway: Develop your customized and physiologically relevant rodent model for ADCY6

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADCY6:
    hsa-mir-96-5p (MIRT001991), hsa-mir-182-5p (MIRT001992), hsa-mir-124-3p (MIRT022147), hsa-mir-335-5p (MIRT016723)

    Block miRNA regulation of human, mouse, rat ADCY6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADCY6 (see all 69):
    hsa-miR-140-5p hsa-miR-323-3p hsa-miR-4254 hsa-miR-631 hsa-miR-1224-3p hsa-miR-128 hsa-miR-3138 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidADCY6 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ADCY6

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): ADCY6 (NM_020983)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY6

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADCY6_HUMAN, O43306: Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005929cilium IEA--
    GO:0016020membrane ISS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with ADCY6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCY6 About   (see all 57)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Adenylate cyclase inhibitory pathway
    Adenylate cyclase inhibitory pathway0.53
    Inhibition of adenylate cyclase pathway0.00
    LPA4-mediated signaling events0.53
    Adenylate cyclase activating pathway0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5ADP signalling through P2Y purinoceptor 12
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    G alpha (z) signalling events0.47


    Find genes that share SuperPaths with ADCY6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADCY6 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ADCY6 (see all 13)
        Development A2A receptor signaling
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling

    Selected BioSystems Pathways for ADCY6 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events
    Endothelins

    Selected Reactome Pathways for ADCY6 (see all 11)
        PKA activation
    PKA activation in glucagon signalling
    G alpha (z) signalling events
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
    Adenylate cyclase inhibitory pathway

    2 PharmGKB Pathways for ADCY6
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADCY6) (see all 31):
        Purine metabolism
    Rap1 signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Adrenergic signaling in cardiomyocytes

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADCY6
    Interactions:

        Search GeneGlobe Interaction Network for ADCY6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCY6 (O433062, 3 ENSP000003114054) via UniProtKB, MINT, STRING, and/or I2D (see all 311)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2856791 I2D: score=3 STRING: ENSP00000244769
    GNASQ5JWF23, ENSP000003601414I2D: score=3 STRING: ENSP00000360141
    CHRNA7P365443, ENSP000003037274I2D: score=2 STRING: ENSP00000303727
    RAF1P040493, ENSP000002518494I2D: score=2 STRING: ENSP00000251849
    ADCY1ENSP000002973234STRING: ENSP00000297323
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process IDA18403039
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with ADCY6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADCY6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    Selected HMDB Compounds for ADCY6 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 Novoseek inferred chemical compound relationships for ADCY6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 64.5 6 15683739 (2), 9841634 (1), 15225617 (1), 15885660 (1) (see all 5)
    dopamine 25.6 1 15683739 (1)



    Find genes that share compounds with ADCY6           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADCY6 gene (2 alternative transcripts): 
    NM_015270.3  NM_020983.2  

    Unigene Cluster for ADCY6:

    Adenylate cyclase 6
    Hs.525401  [show with all ESTs]
    Unigene Representative Sequence: NM_015270
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000547260(uc010slw.1) ENST00000550422(uc001rsi.4 uc001rsj.4)
    ENST00000307885(uc001rsh.4) ENST00000552099 ENST00000548351 ENST00000552090
    ENST00000551435 ENST00000548820 ENST00000357869
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADCY6 (see all 69):
    hsa-miR-140-5p hsa-miR-323-3p hsa-miR-4254 hsa-miR-631 hsa-miR-1224-3p hsa-miR-128 hsa-miR-3138 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidADCY6 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ADCY6 (NM_020983)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY6
    Primer
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    OriGene qPCR primer pairs and template standards for ADCY6
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADCY6
      QuantiTect SYBR Green Assays in human, mouse, rat ADCY6
      QuantiFast Probe-based Assays in human, mouse, rat ADCY6

    Additional mRNA sequence: 

    AB007882.2 AF250226.1 AK294446.1 BX537664.1 U65474.1 

    11 DOTS entries:

    DT.99937161  DT.40108164  DT.91743387  DT.453565  DT.95333624  DT.100777803  DT.100730796  DT.100027161 
    DT.100777796  DT.102831861  DT.75111797 

    7 AceView cDNA sequences:

    BC064923 AB007882 BX537664 U65474 AF250226 NM_015270 NM_020983 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                                                                                                                    
    SP2:                                                                                      -                                             
    SP3:                                                                                                                                    


    ECgene alternative splicing isoforms for ADCY6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADCY6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGAAAG
    ADCY6 Expression
    About this image


    ADCY6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Colon (Gastrointestinal Tract)
     
     Adipose (Muscoskeletal System)
    ADCY6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCY6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525401
        Custom PCR Arrays for ADCY6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADCY6
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADCY6
    QuantiTect SYBR Green Assays in human, mouse, rat ADCY6
    QuantiFast Probe-based Assays in human, mouse, rat ADCY6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ADCY6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy61 , 5 adenylate cyclase 61, 5 88.56(n)1
    94.6(a)1
      15 (54.59 cM)5
    115121  NM_007405.21  NP_031431.21 
     985899945 
    chicken
    (Gallus gallus)
    Aves ADCY66
    adenylate cyclase 6
    93(a)
    1 ↔ 1
    AADN03023257.1(21-1344)
    lizard
    (Anolis carolinensis)
    Reptilia ADCY66
    adenylate cyclase 6
    77(a)
    1 ↔ 1
    2(94460752-94526698)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adcy61 adenylate cyclase 6 70.32(n)
    76.19(a)
      100493933  XM_002935120.2  XP_002935166.2 
    zebrafish
    (Danio rerio)
    Actinopterygii adcy6b1 adenylate cyclase 6b 70.34(n)
    73.6(a)
      560807  XM_002666490.2  XP_002666536.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta rut3 molting cycle (sensu Insecta) adenylate
    cyclase
    49(a)
    (best of 5)
      12F4   --


    ENSEMBL Gene Tree for ADCY6 (if available)
    TreeFam Gene Tree for ADCY6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ADCY6 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    7 SIMAP similar genes for ADCY6 using alignment to 2 protein entries:     ADCY6_HUMAN (see all proteins):
    ADCY5    ADCY1    ADCY3    ADCY2    ADCY4    ADCY8
    ADCY7

    Find genes that share paralogs with ADCY6           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ADCY6 (see all 443)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617388491,2
    C,F--46213184(+) AGCTAG/CCAGCA 1 -- us2k13Minor allele frequency- C:0.46NS WA 196
    rs1469761101,2
    --46213209(+) CACTCA/GGGGAC 1 -- us2k10--------
    rs1384051951,2
    --46213277(+) AGATGC/GGCAGC 1 -- us2k10--------
    rs357841841,2
    C--48996935(+) CCTAAT/-TTTTT 2 -- int11Minor allele frequency- -:0.50NA 2
    rs1906936821,2
    C--49160383(+) TTTCCC/TCTCCT 2 -- ut310--------
    rs1831529561,2
    --49160403(+) ACTAAC/TGAAGT 2 -- ut310--------
    rs1874443401,2
    --49160441(+) GAAGAC/TGCCCA 2 -- ut310--------
    rs1405592051,2
    C--49160514(+) GGGCA-/GGCAGTGC 2 -- cds10--------
    rs1926765191,2
    --49160546(+) CAAACC/GTAGCA 2 -- ut310--------
    rs1462317501,2
    --49160594(+) TCCAAA/GACAAA 2 -- ut310--------
    rs1419335111,2
    C--49160789(+) CACAA-/GGGACT 2 -- ut310--------
    rs1393097871,2
    C--49161015(+) TGGAGA/CACTGG 2 -- ut310--------
    rs1500096011,2
    --49161088(+) CCGAAC/TGGCAC 2 -- ut310--------
    rs79612821,2
    C,F--49161396(+) TCAGGG/TTCACC 2 -- ut31 ese32Minor allele frequency- T:0.13WA NA 238
    rs745121571,2
    C--49161517(+) GACCCC/TGACGG 2 -- ut310--------
    rs1487132671,2
    --49161520(+) CCCGAC/TGGGGT 2 -- ut310--------
    rs1449550111,2
    C--49162082(+) CCTCTC/GCTTCT 2 -- ut310--------
    rs1856387391,2
    C--49162173(+) TTGCAG/TAATCC 2 -- ut310--------
    rs1479631051,2
    --49162197(+) CCCCTG/TGTTTT 2 -- ut310--------
    rs37299731,2
    H--49162253(-) AAAGGG/CAACAT 2 -- ut314Minor allele frequency- C:0.00NS EA 418
    rs1456300641,2
    C--49162436(+) CTTGAC/TCACCC 4 I V mis11Minor allele frequency- T:0.00NA 4550
    rs2002046181,2
    C--49162439(+) GACCAC/GCCCTC 4 L V mis10--------
    rs73001551,2
    C,F,A,H--49162598(+) CCCCAG/ATCCCT 2 -- int116Minor allele frequency- A:0.18NS EA NA WA CSA 962
    rs1876204961,2
    C,F--49162672(+) TGGAAG/TCCCTC 2 -- int11Minor allele frequency- T:0.00EU 1323
    rs732961231,2
    C,F--49162810(+) GCCCCG/AATGAC 4 /I syn15Minor allele frequency- A:0.02WA NA 5082
    rs2005524421,2
    F--49162816(+) ATGACA/CCCTGC 4 G syn11Minor allele frequency- C:0.01EU 517
    rs1418200131,2
    --49162844(+) TCAGCA/CCTGAG 4 G V mis10--------
    rs1455627251,2
    C--49162867(+) GCAAGA/CGACTA 2 -- int10--------
    rs1148602981,2
    C,F--49162940(+) GAGAAA/TAAAAT 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1125046691,2
    C--49163146(+) GTGAGC/TTGTGA 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs1925185271,2
    --49163274(+) CTCCCC/TTGAGT 2 -- int10--------
    rs1848467411,2
    --49163299(+) TATAAC/TAGTAA 2 -- int10--------
    rs1129810791,2
    F--49163796(+) GCCTCG/AGACTC 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1899897111,2
    C--49163805(+) TCCCAA/GAGTGC 2 -- int10--------
    rs1811271281,2
    --49163823(+) ACAGGC/TGTGAG 2 -- int10--------
    rs1845140301,2
    C--49163832(+) AGCCAA/CTGCGC 2 -- int10--------
    rs111687321,2
    C,F,A,H--49164120(+) AACCAA/CATAGT 2 -- int121Minor allele frequency- C:0.21NS EA NA WA CSA 2345
    rs1503203111,2
    --49164195(+) TTATTC/GGACTG 2 -- int10--------
    rs1449098511,2
    C--49164301(+) TTAATC/TTCTCT 2 -- int10--------
    rs1407758691,2
    C--49164334(+) AAAGGC/TGATAA 2 -- int10--------
    rs285551131,2
    --49164407(+) AATATA/CAGACT 2 -- int10--------
    rs785195421,2
    C,F--49164482(+) CCCCAG/ACCTAT 2 -- int11Minor allele frequency- A:0.06WA 118
    rs1889028311,2
    C--49164496(+) CCCAGC/TTTCAC 2 -- int10--------
    rs1149539551,2
    C--49164526(+) AACCCG/ACCAAG 2 -- int11Minor allele frequency- A:0.01WA 118
    rs3729462971,2
    C--49164619(+) ATGGCA/GTAGTC 4 Y syn10--------
    rs1466846691,2
    C--49164648(+) GGAGCG/AGCCCA 4 /R /C mis11Minor allele frequency- A:0.00NA 4550
    rs1402456291,2
    C--49164731(+) GCTGCC/TGGAAC 4 Q R mis11Minor allele frequency- T:0.00NA 4548
    rs1502844921,2
    F--49164741(+) CCGCTC/TCTCGC 4 K E mis11Minor allele frequency- T:0.00NA 4548
    rs1387649871,2
    C--49164776(+) ACCTGA/GCTGTC 2 -- int10--------
    rs98047771,2
    C,F,A,H--49164825(+) ATTTCT/CTGCCA 2 -- int119Minor allele frequency- C:0.10NA NS EA WA 1768
    rs1418045111,2
    --49164829(+) CTTGCC/GACGCC 2 -- int10--------
    rs1819045691,2
    --49164856(+) CTTCCC/TTGTCT 2 -- int10--------
    rs8817381,2
    F,H--49164942(+) CAGGAC/ATTGGG 2 -- int15Minor allele frequency- A:0.01MN NS EA 602
    rs1502910091,2
    C--49165100(+) CATTCC/GTGATC 2 -- int10--------
    rs1466655861,2
    C--49167925(+) GGAAAC/GGGTTG 2 -- int10--------
    rs1904694351,2
    --49167972(+) CTATGA/CCCAGG 2 -- int10--------
    rs37300721,2
    C,F,H--49168128(-) CTGGAC/GACTGG 2 -- int113Minor allele frequency- G:0.12NS EA NA WA 1084
    rs1996796801,2
    --49168170(+) AATTCC/TCACTG 2 -- int10--------
    rs1159572721,2
    C,F--49168221(+) AGGACG/AGAAAA 4 /S syn12Minor allele frequency- A:0.01EA NA 432
    rs2015297471,2
    C--49168253(+) TGCCCG/ATGAGC 4 /R /W mis11Minor allele frequency- A:0.00EU 1323
    rs1838866361,2
    C--49168258(+) GTGAGC/TGGACA 4 H R mis10--------
    rs2003842561,2
    C--49168335(+) AGGTTG/CTATCA 2 -- int11Minor allele frequency- C:0.00EU 1323
    rs1154701301,2
    C,F--49168364(+) CCAGGG/TATGGG 2 -- int11Minor allele frequency- T:0.03WA 118
    rs2010596911,2
    C--49168470(+) CTTACG/ATACAG 2 -- int11Minor allele frequency- A:0.00EU 1307
    rs1434666831,2
    F--49168501(+) CAGATC/GAGCAC 4 L syn11Minor allele frequency- G:0.00NA 4552
    rs1509304091,2
    C--49168506(+) CAGCAC/TGGTGA 4 M V mis11Minor allele frequency- T:0.00NA 4552
    rs2005742061,2
    C--49168507(+) AGCACA/C/GGTGAT 6 T syn10--------
    rs2001728971,2
    --49168569(+) GGGGCA/GGAACA 2 -- int10--------
    rs774716371,2
    C--49168598(+) AATTCT/CGGAAG 2 -- int12Minor allele frequency- C:0.10CSA WA 119
    rs2019969541,2
    C--49168728(+) AAAGGC/TAGGGC 2 -- int10--------
    rs1889268271,2
    C--49168734(+) AGGGCC/TCTCAC 2 -- int10--------
    rs1930750691,2
    C--49168737(+) GCTCTC/TACTGT 2 -- int10--------
    rs779139131,2
    C,F--49168789(+) CAACAG/TGGCAC 4 M L mis14Minor allele frequency- T:0.03WA NA 4196
    rs37300711,2,,4
    C,F,H--49168798(-) ACGTTG/TCCTGT 4 A S mis1 ese38Minor allele frequency- T:0.02NS EA NA EU 4438
    rs2000843281,2
    C--49168819(+) GCGGGG/TATCCA 4 T P mis10--------
    rs1167863571,2
    C,F--49168831(+) CTTCCG/AGGAGT 4 /R /W mis12Minor allele frequency- A:0.00WA NA 3268
    rs37300701,2
    C,F,A,H--49168848(-) GCCTCC/GTCTCC 2 -- int1 trp318Minor allele frequency- G:0.22NS EA NA WA CSA 1446
    rs2003042301,2
    --49168875(+) CCCTCC/GCTAAG 2 -- int10--------
    rs2020889291,2
    --49168876(+) CCTCCA/CTAAGG 2 -- int10--------
    rs1141933081,2
    C--49168885(+) GGAAGG/TCAGGG 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1829709081,2
    C--49169036(+) TGCTGC/TGACCT 2 -- int10--------
    rs1404507021,2
    C--49169052(+) TCCCCC/TAGCCC 2 -- int11Minor allele frequency- T:0.00EU 1323
    rs2007474041,2
    C--49169126(+) GAAACC/TGGCGC 4 Q R mis11Minor allele frequency- T:0.00EU 1323
    rs1866503601,2
    C--49169127(+) AAACCA/GGCGCA 4 R W mis10--------
    rs1446952781,2
    F--49169131(+) CGGCGC/TACATG 4 V syn11Minor allele frequency- T:0.00NA 4552
    rs1166269281,2
    C--49169134(+) CGCACA/GTGGTC 4 H syn11Minor allele frequency- G:0.01WA 216
    rs1485031421,2
    C,F--49169162(+) TGCTGC/TGGGCA 4 H R mis11Minor allele frequency- T:0.00NA 4542
    rs1161699761,2
    C--49169170(+) GCATCG/AATGGC 4 /I syn12Minor allele frequency- A:0.00EA NA 4750
    rs1399463481,2
    F--49169203(+) TCATCC/TTCAGG 4 E syn11Minor allele frequency- T:0.00NA 4550
    rs2008125551,2
    --49169226(+) TTGGGC/TGCCCC 4 T A mis10--------
    rs37300691,2
    C,F,A,H--49169262(-) ATGCAA/TCTGGT 2 -- int116Minor allele frequency- T:0.17NA NS EA WA CSA EU 2131
    rs1918513881,2
    C--49169375(+) AAGGTA/CAGGGA 2 -- int10--------
    rs1995348641,2
    C,F--49169402(+) TCCCCC/ACAGCC 2 -- int11Minor allele frequency- A:0.01EU 587
    rs1380495151,2
    C--49169408(+) CAGCCA/CCATCC 2 -- int10--------
    rs1838368821,2
    --49169694(+) GGGTAC/TTGAGG 2 -- int10--------
    rs1433839171,2
    C,F--49169790(+) GGCACG/AATCAG 4 /R /C mis11Minor allele frequency- A:0.00NA 4472
    rs1141204441,2
    C,F--49169807(+) AGCGCG/AGCATC 4 /P /L mis12Minor allele frequency- A:0.00EA NA 4670
    rs561680171,2
    C,F--49169841(+) AGTCCG/ACTGCA 4 /R /W mis11Minor allele frequency- A:0.00NA 4472
    rs1441534501,2
    C,F--49169860(+) AGCATG/AGCCTT 4 /A syn11Minor allele frequency- A:0.00NA 4478
    rs1998443721,2
    C--49169878(+) TTCTGT/CGCGGG 2 -- int11Minor allele frequency- C:0.00EU 543
    rs1490396481,2
    C,F--49169921(+) GAGGAG/TGCCTT 2 -- int11Minor allele frequency- T:0.01EU 809
    rs1165978601,2
    C,F--49169922(+) AGGAGG/ACCTTG 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1162903551,2
    C,F--49170004(+) TGGCTG/TGCGCC 4 A syn12Minor allele frequency- T:0.00NA 4708
    rs1431140601,2
    C,F--49170029(+) TCTCAA/GTGTGC 4 T I mis12Minor allele frequency- G:0.00NA EU 5875
    rs1162075111,2
    C--49170094(+) TCCCCG/ATTCAG 4 /N syn11Minor allele frequency- A:0.01EU 122
    rs2012271241,2
    C--49170117(+) TGCCCG/AAGTGA 4 /R /W mis11Minor allele frequency- A:0.00EU 1323
    rs2008542981,2
    --49170159(+) GAGACA/CCTGGC 2 -- int10--------
    rs3692549091,2
    C--49170189(+) CCCCCC/G/TCACCT 2 -- int10--------
    rs1381933791,2
    F--49170300(+) ACGCCG/ACAGTG 4 /C syn11Minor allele frequency- A:0.00NA 4544
    rs37300681,2
    C,F,H--49170309(-) GGGCGC/TGTGCA 4 R syn1 ese317Minor allele frequency- T:0.05NS EA NA WA EU 7799
    rs37300671,2
    C,F,H--49170336(-) GTGAAC/TATGCG 4 N syn110Minor allele frequency- T:0.02NS EA WA NA EU 6743
    rs1126222821,2
    C--49170370(+) CCAGCC/GTGGGA 2 -- spa10--------
    rs1124479681,2
    C--49170371(+) CAGCCA/TGGGAG 2 -- spa10--------
    rs766545751,2
    C--49170395(+) ATCAGC/TTCCTG 2 -- int10--------
    rs37300661,2
    C,F--49170425(-) GGGTTG/ATGGGC 2 -- int11Minor allele frequency- A:0.22WA 118
    rs37300651,2
    C,F,H--49170521(-) TGCAGC/GCTTCT 2 -- int16Minor allele frequency- G:0.04NS EA CSA WA 537
    rs1856112671,2
    --49170599(+) AGCTAC/GGAGAA 2 -- int10--------
    rs1430592271,2
    --49170668(+) CCCTAC/TTGCAT 2 -- int10--------
    rs111687331,2
    C,F,A,H--49170719(+) GGTCCG/ACATGG 2 -- int117Minor allele frequency- A:0.13NS EA NA CSA WA 2218
    rs756452861,2
    C,F--49170769(+) ACAGAC/GAGACC 2 -- int11Minor allele frequency- G:0.06WA 118
    rs1907694891,2
    C--49170838(+) AGCAGA/TCTGGG 2 -- int10--------
    rs1820046141,2
    C--49170849(+) GCACCC/TGCAAT 2 -- int10--------
    rs2011028891,2
    C--49170930(+) GCAGTG/TGGCAT 4 N H mis11Minor allele frequency- T:0.00EU 1323
    rs1474693471,2
    C,F--49170952(+) GCCTCC/AGGCAG 4 /P syn11Minor allele frequency- A:0.00NA 4550
    rs1484596531,2
    C,F--49170988(+) CCCAAG/TATCTT 4 I syn11Minor allele frequency- T:0.00NA 4552
    rs1426017971,2
    C,F--49170994(+) ATCTTG/CATCCT 4 /I /M mis12Minor allele frequency- C:0.00NA EU 5875
    rs1882381801,2
    C--49171063(+) TGCCCA/TCCCAG 2 -- int10--------
    rs1812985421,2
    C--49171092(+) CTCCAA/C/TGCATA 2 -- int10--------
    rs2003610531,2
    C--49171147(+) CTCTCA/CCCACG 2 -- int10--------
    rs2022418661,2
    --49171181(+) AGGCCA/CAGCAC 2 -- int10--------
    rs1442466261,2
    C--49171288(+) CTCAAA/TGTCTG 4 I F mis10--------
    rs1398589541,2
    C--49171336(+) GAACAA/C/TATAGC 2 -- int10--------
    rs1907150811,2
    C--49171355(+) ACTTCC/TAGACC 2 -- int10--------
    rs2015623521,2
    C--49171364(+) CCCCCC/G/TGCCCT 2 -- int10--------
    rs1477712771,2
    F--49171487(+) GCAACG/ATGCTG 4 /H syn11Minor allele frequency- A:0.00NA 4552
    rs744689321,2
    C--49171500(+) GCAATA/CCCGAC 4 G V mis10--------
    rs2003582311,2
    --49171538(+) TCCAAC/TAGGGC 2 -- int10--------
    rs1420265221,2
    --49171683(+) GACCAC/GCCTCC 2 -- int10--------
    rs780440671,2
    C,F--49171790(+) AACCAT/CCACAC 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1838065421,2
    --49171806(+) TGCACG/TGAACT 2 -- int10--------
    rs1171578591,2
    C,F--49171875(+) GGTCAC/TGGGGA 2 -- int11Minor allele frequency- T:0.02EA 120
    rs1996515841,2
    --49171879(+) ACGGGC/GAGCAG 2 -- int10--------
    rs2018260421,2
    --49172030(+) GCACAC/TTGGCA 4 N S mis10--------
    rs1506870561,2
    C--49172037(+) GGCACC/TGAGCT 4 S G mis10--------
    rs1172011451,2
    F--49172319(+) TGGGGC/TCCAGC 2 -- int11Minor allele frequency- T:0.07NA 120
    rs1399569691,2
    --49172584(+) TATTAC/TGGTAG 2 -- int10--------
    rs1866743631,2
    --49172807(+) AGCCAC/TCTGCC 2 -- int10--------
    rs1925117121,2
    --49172853(+) AGAGAC/TGGGGT 2 -- int10--------
    rs1498289271,2
    --49172896(+) CTGACC/GTCAAG 2 -- int10--------
    rs748920161,2
    C,F--49172973(+) TGGCCC/TCTAAC 2 -- int11Minor allele frequency- T:0.05WA 118
    rs123061651,2
    C,F,H--49173152(+) atctaT/Cctact 2 -- int120Minor allele frequency- C:0.09NS EA NA WA 2638
    rs116091401,2
    C,H--49173159(+) tactgC/GATTCC 2 -- int10--------
    rs769921051,2
    C,F--49173670(+) ACTGAG/CGGGGA 2 -- int12Minor allele frequency- C:0.14WA NA 238
    rs1838414511,2
    --49173780(+) GAGCTC/TCCCCT 2 -- int10--------
    rs1866885281,2
    --49173804(+) GTGAAC/GAGAGG 2 -- int10--------
    rs1457896421,2
    --49173902(+) GCCCCA/GGGAGC 2 -- int10--------
    rs1398914271,2
    --49173927(+) TGAGTC/TACGGT 2 -- int10--------
    rs1911008331,2
    C--49173987(+) TCCCTA/GTCTGA 2 -- int10--------
    rs1432604651,2
    --49174003(+) AGAAAA/GAATGG 2 -- int10--------
    rs1466759471,2
    --49174198(+) AACCCA/TCATAC 2 -- int10--------
    rs354686401,2
    C,F--49174256(+) GCAGCT/CCTGGC 2 -- int18Minor allele frequency- C:0.27NA CSA WA 427
    rs1144108391,2
    F--49174366(+) GAGACG/AGGCAC 2 -- int11Minor allele frequency- A:0.01WA 118
    rs1153245331,2
    F--49174367(+) AGACGG/TGCACA 2 -- int11Minor allele frequency- T:0.01WA 118
    rs1826106221,2
    C--49174380(+) CCTGGA/CCTCCC 2 -- int10--------
    rs1402244091,2
    C--49174400(+) ACCTCC/TCCAGT 2 -- int10--------
    rs123012711,2
    C,F--49174442(+) CAGTCG/AAGAGC 2 -- int11Minor allele frequency- A:0.12WA 118
    rs1424967171,2
    --49174658(+) GGCTAC/TAAAGT 2 -- int10--------
    rs123146631,2
    C,F,A,H--49174671(+) CTTTTA/TAAAAG 2 -- int110Minor allele frequency- T:0.13NS EA NA WA 770
    rs1868869861,2
    C--49174680(+) AGGTAA/CGTTCT 2 -- int10--------
    rs1926497911,2
    --49174758(+) GCGGGC/TGGATC 2 -- int10--------
    rs1853949761,2
    --49174810(+) AACTTA/GTCTCT 2 -- int10--------
    rs1408627001,2
    C--49174851(+) TGGCGA/CGCTCC 2 -- int10--------
    rs111687341,2
    C,F,A,H--49174858(+) ctcctG/Ctagtc 2 -- int15Minor allele frequency- C:0.44NA CSA 9
    rs1124261761,2
    C,F--49174961(+) CCTAAC/TGACAG 2 -- int12Minor allele frequency- T:0.15WA 120
    rs1899745901,2
    --49174973(+) GCAAGA/CCTCCG 2 -- int10--------
    rs1117480131,2
    F--49174978(+) ACTCCG/ATCTCA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs3678889781,2
    C--49175001(+) ACCAC-/AAAAAA 2 -- int10--------
    rs108758741,2
    C,F,A,H--49175195(+) GGACCC/AAGGCG 2 -- int19Minor allele frequency- A:0.24NA WA CSA EA 369
    rs1416861251,2
    --49175200(+) CAGGCA/GCTGTG 2 -- int10--------
    rs1470573981,2
    C--49175413(+) CTACTC/TCACTC 2 -- int10--------
    rs1147342891,2
    C,F--49175461(+) ATGCTA/GTTTTT 2 -- int11Minor allele frequency- G:0.02WA 118
    rs1419604741,2
    --49175570(+) GCCTA-/CCCCC 
            
    CAGCC
    2 -- int10--------
    rs1383223411,2
    --49175750(+) TTCAAA/TCCACA 2 -- int10--------
    rs1495681161,2
    --49175801(+) TGTCCC/TCCCAG 2 -- int10--------
    rs1428903421,2
    C--49175982(+) CTGCC-/TTTTCA 2 -- int10--------
    rs1932907191,2
    --49176038(+) CCCCAC/TATTCT 2 -- int10--------
    rs1847446721,2
    --49176070(+) TCAGCA/GGGCTA 2 -- int10--------
    rs1882903101,2
    --49176097(+) GGCCCA/TTGGTG 2 -- int10--------
    rs1807554361,2
    --49176119(+) GCTTGA/GGTCCT 2 -- int10--------
    rs1852596021,2
    --49176465(+) AGGAGC/TGTGTA 4 T syn10--------
    rs2005936801,2
    --49176503(+) CCAGAC/GGCCCG 4 L V mis10--------
    rs1458463901,2
    F--49176507(+) AGGCCC/TGCAGA 4 A syn11Minor allele frequency- T:0.00NA 2918
    rs2007753281,2
    C--49176579(+) ACCACG/ATAGCT 4 /Y syn11Minor allele frequency- A:0.00EU 903
    rs37300641,2
    C,F,H--49176582(-) GTGAGC/TTACGT 4 S syn120Minor allele frequency- T:0.04NS EA NA EU 7605
    rs1999914981,2
    --49176629(+) ACACAC/TCACCA 4 M V mis10--------
    rs1887956841,2
    C--49176632(+) CACCAC/TCATGA 4 M V mis10--------
    rs1153156711,2
    C,F--49176805(+) ACAGGC/TGCTCC 4 H R mis14Minor allele frequency- T:0.02EU WA NA 5053
    rs1140213181,2
    C--49176808(+) GGCGCT/CCCAGC 4 /E /G mis11Minor allele frequency- C:0.01WA 168
    rs1508039441,2
    C,F--49176820(+) TGGCCA/C/GAACGG 6 S W L mis12NA EU 4747
    rs557700451,2
    C,F--49176860(+) ACGGCG/ACCAGC 4 /R /C mis15Minor allele frequency- A:0.01NA EU 5211
    rs37303081,2
    C,F--49176872(-) GTGGGC/AGATCC 4 /R syn1 ese314Minor allele frequency- A:0.18NA WA CSA EU 5620
    rs1486509321,2
    F--49176897(+) TCGGGC/AGCCAC 4 /A syn11Minor allele frequency- A:0.00NA 4066
    rs1141250231,2
    F--49176933(+) GTCACC/TTCGGT 4 E syn11Minor allele frequency- T:0.01WA 198
    rs37303071,2
    C--49176995(-) GGGGCA/GGCCCA 4 S G mis1 ese30--------
    rs24534861,2
    C,F,A--49177113(+) CCACCT/GGCCCG 4 /A syn1 ese318Minor allele frequency- G:0.30NA EA WA CSA EU 7832
    rs1415748371,2
    C,F--49177117(+) CTGCCC/TGAGTG 4 Q R mis11Minor allele frequency- T:0.00NA 4390
    rs1393885581,2
    F--49177132(+) GGCGCC/TGCGAA 4 Q R mis11Minor allele frequency- T:0.00NA 4478
    rs2002930961,2
    C--49177285(+) CACCAC/TCNNNN 2 -- int1 ut510--------
    rs1403711791,2
    C--49177287(+) CATCA-/CCCCAGCC 2 -- cds10--------
    rs1998421461,2
    C--49177287(-) GGCTGG/TGNNNN 2 -- int1 ut510--------
    rs1812759161,2
    --49177395(+) CCCCAA/GTCAAC 2 -- int1 ut510--------
    rs800223231,2
    C--49177415(+) CCCAAA/GACACA 2 -- int1 ut510--------
    rs1871491921,2
    --49177436(+) GAAACA/TTGCCC 2 -- int1 ut510--------
    rs1396770651,2
    C--49177617(+) AATCCC/GAGCAC 2 -- int1 ut510--------
    rs1433016631,2
    C--49177723(+) TAGCCA/GGGCGT 2 -- int1 ut510--------
    rs342750951,2
    C--49177822(+) ATCGCG/ACCATT 2 -- int1 ut511Minor allele frequency- A:0.50NA 2
    rs1462209741,2
    --49177882(+) ATTAGC/TCTGGT 2 -- int1 us2k10--------
    rs357967201,2
    C--49178023(+) GCCTG-/AAAAAA 2 -- int1 us2k10--------
    rs1914183661,2
    --49178064(+) GGAGGC/GAGGGA 2 -- int1 us2k10--------
    rs1840644201,2
    --49178232(+) GTATAC/TTTGAA 2 -- int1 us2k10--------
    rs732961371,2
    C,F--49178323(+) AACTGG/CGAGGA 2 -- int1 us2k12Minor allele frequency- C:0.12WA 120
    rs1861488391,2
    --49178351(+) TGCATA/GGGGCA 2 -- int1 us2k10--------
    rs1897797151,2
    --49178401(+) CAGTGA/GGTCCC 2 -- int1 us2k10--------
    rs1823074071,2
    --49178519(+) GGCACA/GATCTT 2 -- int1 us2k10--------
    rs1390755641,2
    --49178549(+) CTCCCA/GGGTTC 2 -- int1 us2k10--------
    rs1865783131,2
    --49178583(+) CTGGGA/GCTACA 2 -- int1 us2k10--------
    rs1916097771,2
    --49178655(+) GTGTTA/CGCTAG 2 -- int1 us2k10--------
    rs1829601061,2
    --49178744(+) CACCCC/TAGTCA 2 -- int1 us2k10--------
    rs1498813461,2
    --49178834(+) GAACAA/GGAGCT 2 -- int1 us2k10--------
    rs1886862271,2
    --49178871(+) CTTATC/TAGTGA 2 -- int1 us2k10--------
    rs1491737581,2
    C--49178927(+) AGCTC-/TCTA  
            
    TCTTT
    2 -- int1 us2k10--------
    rs1448672971,2
    --49179047(+) ATGAAA/GGCAAG 2 -- int1 us2k10--------
    rs111687361,2
    C,F--49179090(+) ACAACC/GCTTAG 2 -- int1 us2k17Minor allele frequency- G:0.29NA WA 248
    rs111687371,2
    C,F,A--49179153(+) ATCCCA/GGCACT 2 -- int1 us2k15Minor allele frequency- G:0.40NA WA 10
    rs609467921,2
    C,F--49179172(+) CCGAGG/ATGAGT 2 -- int1 us2k11Minor allele frequency- A:0.50WA 2
    rs111687381,2
    C,F,A--49179211(+) CAGCCG/TGACCA 2 -- int1 us2k15Minor allele frequency- T:0.40NA WA 10
    rs1928057201,2
    --49179312(+) TGAGAA/GAATCA 2 -- int1 us2k10--------
    rs1413118451,2
    C--49179367(+) ATTGCA/GCTCCA 2 -- int1 us2k10--------
    rs1849918091,2
    --49179442(+) GTAGAC/TGGATG 2 -- int1 us2k10--------
    rs73006211,2
    C--49180075(+) CATCCC/G/TTGAGT 1 -- int1 tfbs30--------
    rs108758751,2
    C,F,A--49180095(+) CCAAGA/TTCTGT 1 -- int16Minor allele frequency- T:0.20NA WA EA 364
    rs24469971,2
    C,F,O,H--49180102(+) CTGTCG/AGCACC 1 -- int113Minor allele frequency- A:0.17EA NS NA WA CSA 550
    rs1877451781,2
    --49180197(+) TAGGCC/TGGAGT 1 -- int10--------
    rs1924581881,2
    --49180353(+) GTTGGC/TCAGGC 1 -- int10--------
    rs111687391,2
    C,F,A,H--49180370(+) cgaacT/Ccctaa 1 -- int19Minor allele frequency- C:0.01NS EA NA WA 428
    rs1839684511,2
    --49180548(+) GAAAGC/TCTTGC 1 -- int10--------
    rs1891451281,2
    --49180617(+) TAGCGC/TGATTA 1 -- int10--------
    rs111687401,2
    C,F,A,H--49180633(+) tagccA/Gcactg 1 -- int121Minor allele frequency- G:0.27NS EA NA WA CSA 2229
    rs1814129201,2
    --49180713(+) CAGGAA/CAGAAT 1 -- int10--------
    rs1845629371,2
    --49180746(+) ACACAC/TTTGAA 1 -- int10--------
    rs1903273281,2
    --49180765(+) GTTCTC/TCTCCT 1 -- int10--------
    rs1159543311,2
    C,F--49180783(+) CAACAC/TTTTAA 1 -- int11Minor allele frequency- T:0.03WA 118
    rs358014601,2
    C,F--49180828(+) ATGAGG/AAAATC 1 -- int113Minor allele frequency- A:0.21NA EA WA CSA 731
    rs1137172601,2
    ----49175080(+) CTCACC/TCTGGG 2 -- int11Minor allele frequency- T:0.50CSA 2
    rs3694750471,2
    ----49162186(+) TCGGTA/TGGTAG 2 -- ut310--------
    rs361194081,2
    ----49172709(+) AGACT-/GGGAGT 2 -- int10--------
    rs3741976781,2
    ----49171343(+) TAGCCC/TTCAAA 2 -- int10--------
    rs3767820871,2
    ----49176639(+) ATGAGC/TCCCAC 4 G syn10--------
    rs3683039781,2
    ----49170049(+) AGGTAC/TGCGTT 4 A syn10--------
    rs3726943351,2
    ----49168830(+) CCTTCC/TGGGAG 4 Q R mis10--------
    rs2003807591,2
    ----49171534(+) TGGTTC/GCAATA 2 -- int11Minor allele frequency- G:0.00EU 1323
    rs720546341,2
    ----49172682(+) TTTTG-/TACAGA 2 -- int10--------
    rs562584921,2
    ----49161050(+) TGCCAA/CAGACA 2 -- ut310--------
    rs1462403101,2
    ----49169805(+) CCAGCG/ACGGCA 4 /R /C mis11Minor allele frequency- A:0.00NA 4472
    rs3712974301,2
    ----49168309(+) AGAGGA/CATCAA 2 -- int10--------
    rs3721631911,2
    ----49164411(+) TCAGAC/TTTGAT 2 -- int10--------
    rs714649321,2
    ----49171002(+) CCTCAG/AGCAGT 4 /L syn11Minor allele frequency- A:0.50NA 2
    rs10445741,2
    ----49160893(-) TCCCTC/TTGAGG 2 -- ut31 ese33Minor allele frequency- T:0.00MN NA 188
    rs1391857981,2
    ----49168838(+) GAGTAC/TTGAGG 2 -- spa11Minor allele frequency- T:0.00NA 2958
    rs3687979911,2
    ----49168239(+) ACTGCA/GGTGCT 4 T syn10--------
    rs570084291,2
    ----49163231(+) ACAAAA/TAAAAA 2 -- int10--------
    rs1426599111,2
    ----49171988(+) AGTGTG/ATGCAG 4 /T /I mis11Minor allele frequency- A:0.00NA 4552
    rs3716072981,2
    ----49169547(+) TCCTTC/GCCCCA 2 -- int10--------
    rs79693461,2
    ----49163542(+) tttttG/Tttttt 2 -- int10--------
    rs3745715821,2
    ----49176727(+) GCACCA/GCTGTG 4 A V mis10--------
    rs776581681,2
    ----49177865(+) GTCTCC/AAAAAA 2 -- int1 ut511Minor allele frequency- A:0.00NA 2
    rs3707095581,2
    ----49160950(+) TCTGGA/GAAGCC 2 -- ut310--------
    rs3723551891,2
    ----49177944(+) ATTGCC/TTGGGC 2 -- int1 us2k10--------
    rs3734407691,2
    ----49169778(+) GGTCCA/GGGAGA 4 R W mis10--------
    rs3691449201,2
    ----49165787(+) TTGCCC/TGACAT 2 -- int10--------
    rs3763297791,2
    ----49176902(+) CGCCAC/TCTCAG 4 M V mis10--------
    rs3675589031,2
    ----49174939(+) TCGCGC/TACTGC 2 -- int10--------
    rs3725882231,2
    ----49164787(+) AAGGCA/TAAGAC 2 -- int10--------
    rs3751138081,2
    ----49177032(+) GGGCAA/CCGAGG 4 R syn10--------
    rs3705048241,2
    ----49171045(+) GGGTAA/GCCTTT 2 -- int10--------
    rs3701245871,2
    ----49180659(+) TTTAA-/CTTCTCT 1 -- int10--------
    rs3681803651,2
    ----49169409(+) AGCCCC/GATCCC 2 -- int10--------
    rs3691496801,2
    ----49170283(+) ATTTCC/TGCAAG 4 Q R mis10--------
    rs3687728651,2
    ----49171190(+) ACCCTC/TACCGC 2 -- int10--------
    rs1497647901,2
    ----49162393(+) CCCCAT/CTGAGG 4 /N /S mis11Minor allele frequency- C:0.00NA 4550
    rs3716875651,2
    ----49174671(+) CTTTT-/A/TAAAAG 2 -- int10--------
    rs1116350051,2
    ----49173641(+) TTTGGT/GACCTC 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs557268271,2
    ----49168810(+) GGCTCC/TGAAGC 4 R G mis10--------
    rs3724761641,2
    ----49169591(+) GGGGG-/GCACTG 2 -- int10--------
    rs3736586551,2
    ----49169239(+) CTGAGA/GGCAGG 2 -- int10--------
    rs3772223881,2
    ----49168514(+) TGATTA/GGCAGC 4 P L mis10--------
    rs3760794891,2
    ----49169908(+) GAAGAA/GGGCCC 2 -- int10--------
    rs3709806581,2
    ----49168238(+) AACTGC/GGGTGC 4 P A mis10--------
    rs3687679291,2
    ----49176817(+) GCTTGA/GCCGAA 4 A V mis10--------
    rs3728962651,2
    ----49170297(+) AGGACA/GCCGCA 4 G syn10--------
    rs3761013181,2
    ----49169441(+) TCCTCA/TGTAAC 2 -- int10--------
    rs3756053221,2
    ----49176361(+) GCTTCC/TAGAGG 4 * W stg10--------
    rs3741026451,2
    ----49160380(+) TCTTTC/TCCCCT 2 -- ut310--------
    rs3688279551,2
    ----49178623(+) TTTTT-/TAGTAG 2 -- int1 us2k10--------
    rs2012620161,2
    ----49178098(+) AAATA-/AAATA 
            
    CAAAG
    2 -- int1 us2k10--------
    rs714649311,2
    ----49160095(+) CACGGG/CCTCCC 2 -- ut311Minor allele frequency- C:0.50NA 2
    rs3747282101,2
    ----49169264(+) CAGTTA/GCATGG 2 -- int10--------
    rs3679372301,2
    ----49176901(+) GCGCCA/GCCTCA 4 A V mis10--------
    rs1126996671,2
    ----49170450(+) TCTCAG/CGGCCC 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs1473620881,2
    ----49177014(+) AAGGCG/ATCATC 4 /D syn11Minor allele frequency- A:0.00NA 2602
    rs3762208091,2
    ----49170940(+) TGGTCA/GGCCCG 4 A syn10--------
    rs560091291,2
    ----49161521(+) CCGACA/GGGGTC 2 -- ut310--------
    rs1505372421,2
    ----49171214(+) AACCGG/AGCAAA 4 /A syn11Minor allele frequency- A:0.00NA 4550
    rs3767514001,2
    ----49163000(+) AGCCTA/GCCAAC 2 -- int10--------
    rs747680621,2
    ----49174982(+) CGTCTA/CAAAAA 2 -- int11Minor allele frequency- C:0.00NA 2
    rs1450260351,2
    ----49176693(+) TGAGGG/ACGGGC 4 /R syn11Minor allele frequency- A:0.00NA 4260
    rs3723658391,2
    ----49162434(+) ACCTTC/GACCAC 4 V syn10--------
    rs1997495051,2
    ----49168280(+) CAGACG/ATTGCA 4 /R /C mis11Minor allele frequency- A:0.00EU 1323
    rs3727967821,2
    ----49162522(+) GAGCCC/TGCTTA 2 -- int10--------
    rs1489860451,2
    ----49176508(+) GGCCCG/ACAGAG 4 /A /V mis11Minor allele frequency- A:0.00NA 2894
    rs3687923671,2
    ----49176559(+) CTGCCG/TCCAGG 4 E A mis10--------
    rs1427418241,2
    ----49176936(+) ACCTCG/AGTATC 4 /T syn11Minor allele frequency- A:0.00NA 3730
    rs1118745471,2
    ----49174722(+) CTCACG/CCTTGT 2 -- int11Minor allele frequency- C:0.50CSA 2
    rs3702376621,2
    ----49180904(+) GCTGTC/TGTCCC 1 -- int10--------
    rs1483460711,2
    ----49170063(+) CTCGCC/TACCAC 4 S G mis11Minor allele frequency- T:0.00NA 4552
    rs1412930161,2
    ----49176657(+) GCGGCG/AGCACA 4 /A syn11Minor allele frequency- A:0.00NA 4380
    rs3677054091,2
    ----49171363(+) ACCCCC/GCGCCC 2 -- int10--