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Aliases for ADCY6 Gene

Aliases for ADCY6 Gene

  • Adenylate Cyclase 6 2 3
  • Ca(2+)-Inhibitable Adenylyl Cyclase 3 4
  • Adenylate Cyclase Type VI 3 4
  • ATP Pyrophosphate-Lyase 6 3 4
  • Adenylyl Cyclase 6 3 4
  • EC 4.6.1.1 4 64
  • Adenylate Cyclase Type 6 3
  • KIAA0422 4
  • LCCS8 3
  • AC6 3

External Ids for ADCY6 Gene

Summaries for ADCY6 Gene

Entrez Gene Summary for ADCY6 Gene

  • This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY6 Gene

ADCY6 (Adenylate Cyclase 6) is a Protein Coding gene. Diseases associated with ADCY6 include thyroid adenoma and adenoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein kinase binding and adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY6 Gene

  • Membrane-bound, calcium-inhibitable adenylyl cyclase.

Tocris Summary for ADCY6 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5-triphosphate (ATP) into 3,5-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY6 Gene

Genomics for ADCY6 Gene

Genomic Location for ADCY6 Gene

Start:
48,766,192 bp from pter
End:
48,789,037 bp from pter
Size:
22,846 bases
Orientation:
Minus strand

Genomic View for ADCY6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY6 Gene

Regulatory Elements for ADCY6 Gene

Proteins for ADCY6 Gene

  • Protein details for ADCY6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43306-ADCY6_HUMAN
    Recommended name:
    Adenylate cyclase type 6
    Protein Accession:
    O43306
    Secondary Accessions:
    • Q9NR75
    • Q9UDB0

    Protein attributes for ADCY6 Gene

    Size:
    1168 amino acids
    Molecular mass:
    130615 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1.
    SequenceCaution:
    • Sequence=BAA24852.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ADCY6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY6 Gene

Proteomics data for ADCY6 Gene at MOPED

Post-translational modifications for ADCY6 Gene

Other Protein References for ADCY6 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ADCY6 Gene

Gene Families for ADCY6 Gene

HGNC:
  • ADCY :Adenylate cyclases
IUPHAR :

Protein Domains for ADCY6 Gene

UniProtKB/Swiss-Prot:

ADCY6_HUMAN
Domain:
  • Contains 2 guanylate cyclase domains.:
    • O43306
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.:
    • O43306
genes like me logo Genes that share domains with ADCY6: view

Function for ADCY6 Gene

Molecular function for ADCY6 Gene

GENATLAS Biochemistry: adenylyl cyclase,type VI,ubiquitous
UniProtKB/Swiss-Prot CatalyticActivity: ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation by RAF1 results in its activation.
UniProtKB/Swiss-Prot Function: Membrane-bound, calcium-inhibitable adenylyl cyclase.

Enzyme Numbers (IUBMB) for ADCY6 Gene

Gene Ontology (GO) - Molecular Function for ADCY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity IDA 18403039
GO:0005515 protein binding IPI 17081159
GO:0005524 ATP binding IEA --
GO:0016849 phosphorus-oxygen lyase activity --
GO:0019901 protein kinase binding ISS --
genes like me logo Genes that share ontologies with ADCY6: view
genes like me logo Genes that share phenotypes with ADCY6: view

Animal Models for ADCY6 Gene

MGI Knock Outs for ADCY6:

miRNA for ADCY6 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for ADCY6 Gene

Localization for ADCY6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY6 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY6 Gene COMPARTMENTS Subcellular localization image for ADCY6 gene
Compartment Confidence
plasma membrane 4
cytosol 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADCY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005929 cilium IEA --
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCY6: view

Pathways for ADCY6 Gene

SuperPathways for ADCY6 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY6: view

Gene Ontology (GO) - Biological Process for ADCY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process IDA 18403039
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY6: view

Compounds for ADCY6 Gene

(5) Tocris Compounds for ADCY6 Gene

Compound Action Cas Number
KH 7 Selective soluble adenylyl cyclase inhibitor [330676-02-3]
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(11) HMDB Compounds for ADCY6 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for ADCY6 Gene

Compound -log(P) Hits PubMed IDs
adenylate 64.5 6
dopamine 25.6 1
genes like me logo Genes that share compounds with ADCY6: view

Transcripts for ADCY6 Gene

mRNA/cDNA for ADCY6 Gene

(8) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ADCY6 Gene

Adenylate cyclase 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: -
SP3:

Relevant External Links for ADCY6 Gene

GeneLoc Exon Structure for
ADCY6
ECgene alternative splicing isoforms for
ADCY6

Expression for ADCY6 Gene

mRNA expression in normal human tissues for ADCY6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADCY6 Gene

SOURCE GeneReport for Unigene cluster for ADCY6 Gene Hs.525401

genes like me logo Genes that share expressions with ADCY6: view

Orthologs for ADCY6 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY6 36
  • 99.64 (n)
  • 99.55 (a)
ADCY6 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCY6 36
  • 91.31 (n)
  • 95.54 (a)
ADCY6 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY6 36
  • 92.74 (n)
  • 96.66 (a)
ADCY6 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy6 36
  • 88.56 (n)
  • 94.6 (a)
Adcy6 16
Adcy6 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY6 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy6 36
  • 87.85 (n)
  • 93.74 (a)
chicken
(Gallus gallus)
Aves ADCY6 37
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY6 37
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy6 36
  • 70.32 (n)
  • 76.19 (a)
zebrafish
(Danio rerio)
Actinopterygii adcy6a 37
  • 71 (a)
OneToMany
adcy6b 36
  • 70.34 (n)
  • 73.6 (a)
adcy6b 37
  • 72 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43373 37
  • 29 (a)
OneToMany
ACXC 38
  • 26 (a)
ACXA 38
  • 25 (a)
rut 38
  • 49 (a)
ACXB 38
  • 26 (a)
ACXE 38
  • 26 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-2 38
  • 41 (a)
acy-4 38
  • 49 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 48 (a)
OneToMany
Species with no ortholog for ADCY6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY6 Gene

ENSEMBL:
Gene Tree for ADCY6 (if available)
TreeFam:
Gene Tree for ADCY6 (if available)

Paralogs for ADCY6 Gene

Selected SIMAP similar genes for ADCY6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ADCY6: view

Variants for ADCY6 Gene

Sequence variations from dbSNP and Humsavar for ADCY6 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs881738 -- 48,771,159(+) CAGGA(A/C)TTGGG intron-variant
rs1044574 -- 48,767,110(-) TCCCT(C/T)TGAGG utr-variant-3-prime
rs2446997 -- 48,786,319(+) CTGTC(A/G)GCACC intron-variant
rs2453486 -- 48,783,330(+) CCACC(G/T)GCCCG reference, synonymous-codon
rs3729973 -- 48,768,470(-) AAAGG(C/G)AACAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ADCY6 Gene

Variant ID Type Subtype PubMed ID
nsv826363 CNV Gain 20364138

Relevant External Links for ADCY6 Gene

HapMap Linkage Disequilibrium report
ADCY6
Human Gene Mutation Database (HGMD)
ADCY6

Disorders for ADCY6 Gene

(1) University of Copenhagen DISEASES for ADCY6 Gene

Relevant External Links for ADCY6

Genetic Association Database (GAD)
ADCY6
Human Genome Epidemiology (HuGE) Navigator
ADCY6
genes like me logo Genes that share disorders with ADCY6: view

No data available for UniProtKB/Swiss-Prot for ADCY6 Gene

Publications for ADCY6 Gene

  1. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9455477) Ishikawa K. … Ohara O. (DNA Res. 1997) 3 4
  2. Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues. (PMID: 10978539) Wicker R. … Suarez H.G. (Biochim. Biophys. Acta 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  5. Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy. (PMID: 14871025) Ikoma E. … Ishikawa Y. (J. Cardiovasc. Pharmacol. 2003) 3 49

Products for ADCY6 Gene

Sources for ADCY6 Gene

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