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ADCY6 Gene

protein-coding   GIFtS: 73
GCID: GC12M049159

Adenylate Cyclase 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase 61 2     EC 4.6.1.13 8
Adenylate Cyclase Type VI2 3     AC62
Adenylyl Cyclase 62 3     Adenylate Cyclase Type 62
Ca(2+)-Inhibitable Adenylyl Cyclase2 3     KIAA04223
ATP Pyrophosphate-Lyase 62 3     

External Ids:    HGNC: 2371   Entrez Gene: 1122   Ensembl: ENSG000001742337   OMIM: 6002945   UniProtKB: O433063   

Export aliases for ADCY6 gene to outside databases

Previous GC identifers: GC12P061214 GC12M049170 GC12M048876 GC12M047446 GC12M046193


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCY6 Gene:
This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the
secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid
and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning
thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ADCY6 Gene:
ADCY6 (adenylate cyclase 6) is a protein-coding gene. Diseases associated with ADCY6 include precocious puberty, and thyroid adenoma. GO annotations related to this gene include adenylate cyclase activity and protein kinase binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306
Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)

summary for ADCY6 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCY6 gene promoter:
         MZF-1   Sp1   HNF-1   Pax-2   Pax-2a   HNF-1A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCY6 promoter sequence
   Search Chromatin IP Primers for ADCY6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCY6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12-q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q12-q13

ADCY6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY6 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M049159:  view genomic region     (about GC identifiers)

Start:
49,159,975 bp from pter      End:
49,182,820 bp from pter
Size:
22,846 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306 (See protein sequence)
Recommended Name: Adenylate cyclase type 6  
Size: 1168 amino acids; 130615 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subunit: Part of a complex containing AKAP5, ADCY5, PDE4C and PKD2 (By similarity). Interacts with RAF1
Sequence caution: Sequence=BAA24852.2; Type=Erroneous initiation;
Secondary accessions: Q9NR75 Q9UDB0
Alternative splicing: 2 isoforms:  O43306-1   O43306-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADCY6: NX_O43306

Explore proteomics data for ADCY6 at MOPED

Post-translational modifications: 

  • Phosphorylated by RAF11
  • Ubiquitination2 at Lys129
  • Glycosylation2 at Asn793
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADCY6 (O43306) (see all 35)
     AGRIHIT  EKIKTIG  FHKIYIQ  IETFLIL 


    See ADCY6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_056085.1  NP_066193.1  

    ENSEMBL proteins: 
     ENSP00000446730   ENSP00000311405   ENSP00000447702   ENSP00000350536  
    Reactome Protein details: O43306

    ADCY6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADCY6
    GenScript Custom Purified and Recombinant Proteins Services for ADCY6
    Novus Biologicals ADCY6 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY6

    ADCY6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ADCY6
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    Novus Biologicals ADCY6 Antibodies
    Abcam antibodies for ADCY6
    Cloud-Clone Corp. Antibodies for ADCY6
    ThermoFisher Antibodies for ADCY6
    LSBio Antibodies in human, mouse, rat for ADCY6

    ADCY6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADCY6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADCY6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADCY6
    Cloud-Clone Corp. CLIAs for ADCY6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC6
    Adenylyl cyclases

    3 InterPro protein domains:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry O43306

    ProtoNet protein and cluster: O43306

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY6_HUMAN, O43306
    Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation
    by RAF1 results in its activation

         Genatlas biochemistry entry for ADCY6:
    adenylyl cyclase,type VI,ubiquitous

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004016adenylate cyclase activity IDA18403039
    GO:0005515protein binding IPI17081159
    GO:0005524ATP binding IEA--
    GO:0016849phosphorus-oxygen lyase activity ----
    GO:0019901protein kinase binding ISS--
         
    ADCY6 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADCY6:
     G0/1 arrest  Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adcy6):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  muscle  renal/urinary system 

    ADCY6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADCY6: Adcy6tm2Yich Adcy6tm1Hkh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADCY6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADCY6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY6

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADCY6:
    hsa-mir-96-5p (MIRT001991), hsa-mir-182-5p (MIRT001992), hsa-mir-124-3p (MIRT022147), hsa-mir-335-5p (MIRT016723)

    Block miRNA regulation of human, mouse, rat ADCY6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADCY6 (see all 69):
    hsa-miR-140-5p hsa-miR-323-3p hsa-miR-4254 hsa-miR-631 hsa-miR-1224-3p hsa-miR-128 hsa-miR-3138 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidADCY6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADCY6
    Predesigned siRNA for gene silencing in human, mouse, rat ADCY6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADCY6

    Clone
    Products:
         
    OriGene clones in human, mouse for ADCY6 (see all 13)
    OriGene ORF clones in mouse, rat for ADCY6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADCY6 (NM_020983)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADCY6
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADCY6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADCY6_HUMAN, O43306: Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005929cilium IEA--
    GO:0016020membrane ISS--
    GO:0016021integral component of membrane IEA--

    ADCY6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCY6 About   (see all 57)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Adenylate cyclase inhibitory pathway
    Adenylate cyclase inhibitory pathway0.53
    Inhibition of adenylate cyclase pathway0.00
    LPA4-mediated signaling events0.53
    Adenylate cyclase activating pathway0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5ADP signalling through P2Y purinoceptor 12
    Inhibition of Insulin Secretion by Adrenaline/Noradrenaline0.64
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34
    G alpha (z) signalling events0.47

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADCY6 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ADCY6 (see all 13)
        Development A2A receptor signaling
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling

    Selected BioSystems Pathways for ADCY6 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events
    Endothelins

    Selected Reactome Pathways for ADCY6 (see all 11)
        PKA activation
    PKA activation in glucagon signalling
    G alpha (z) signalling events
    Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
    Adenylate cyclase inhibitory pathway

    2 PharmGKB Pathways for ADCY6
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADCY6) (see all 31):
        Purine metabolism
    Rap1 signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Adrenergic signaling in cardiomyocytes


    ADCY6 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADCY6
    Interactions:

        Search GeneGlobe Interaction Network for ADCY6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCY6 (O433062, 3 ENSP000003114054) via UniProtKB, MINT, STRING, and/or I2D (see all 311) (see top 5)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532, 3, ENSP000002447694MINT-2856791 I2D: score=3 STRING: ENSP00000244769
    GNASQ5JWF23, ENSP000003601414I2D: score=3 STRING: ENSP00000360141
    CHRNA7P365443, ENSP000003037274I2D: score=2 STRING: ENSP00000303727
    RAF1P040493, ENSP000002518494I2D: score=2 STRING: ENSP00000251849
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY8ENSP000002863554STRING: ENSP00000286355
    ADCY9ENSP000002940164STRING: ENSP00000294016
    ADMENSP000002781754STRING: ENSP00000278175
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADORA2AENSP000003366304STRING: ENSP00000336630
    ADORA2BENSP000003045014STRING: ENSP00000304501
    ADRB1ENSP000003583014STRING: ENSP00000358301
    ADRB2ENSP000003053724STRING: ENSP00000305372
    AVPR2ENSP000003380724STRING: ENSP00000338072
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    CALCAENSP000003317464STRING: ENSP00000331746
    CALCRENSP000003525614STRING: ENSP00000352561
    CASRENSP000002961544STRING: ENSP00000296154
    CHRM2ENSP000003199844STRING: ENSP00000319984
    CRHENSP000002765714STRING: ENSP00000276571
    DRD2ENSP000003548594STRING: ENSP00000354859
    DRD3ENSP000003731694STRING: ENSP00000373169
    GALR2ENSP000003296844STRING: ENSP00000329684
    GALR3ENSP000002490414STRING: ENSP00000249041
    GCGENSP000003876624STRING: ENSP00000387662
    GCGRENSP000003835584STRING: ENSP00000383558
    GNB3ENSP000002292644STRING: ENSP00000229264
    HTR1EENSP000003077664STRING: ENSP00000307766
    HTR1FENSP000003229244STRING: ENSP00000322924
    KNG1ENSP000002650234STRING: ENSP00000265023
    MC2RENSP000003338214STRING: ENSP00000333821
    MC3RENSP000002439114STRING: ENSP00000243911
    MC5RENSP000003180774STRING: ENSP00000318077
    NPYENSP000002421524STRING: ENSP00000242152
    P2RY12ENSP000003072594STRING: ENSP00000307259
    P2RY13ENSP000003203764STRING: ENSP00000320376
    P2RY14ENSP000003083614STRING: ENSP00000308361
    P2RY4ENSP000003636434STRING: ENSP00000363643
    PDE11AENSP000002860634STRING: ENSP00000286063
    PDE1AENSP000003315744STRING: ENSP00000331574
    PDE1BENSP000002430524STRING: ENSP00000243052
    PDE1CENSP000003794854STRING: ENSP00000379485
    PDE3AENSP000003519574STRING: ENSP00000351957
    PDE3BENSP000002820964STRING: ENSP00000282096
    PDE5AENSP000003470464STRING: ENSP00000347046
    PDE7AENSP000003687304STRING: ENSP00000368730
    PDE7BENSP000003106614STRING: ENSP00000310661
    PDYNENSP000002173054STRING: ENSP00000217305
    PKLRENSP000003399334STRING: ENSP00000339933
    PKMENSP000003201714STRING: ENSP00000320171
    POMCENSP000002647084STRING: ENSP00000264708
    PRKACAENSP000003095914STRING: ENSP00000309591
    PRKACBENSP000003597194STRING: ENSP00000359719
    PRKACGENSP000003664884STRING: ENSP00000366488
    PRKAR1AENSP000003514104STRING: ENSP00000351410
    PRKCEENSP000003061244STRING: ENSP00000306124
    PRKXENSP000002628484STRING: ENSP00000262848
    PTGER2ENSP000002454574STRING: ENSP00000245457
    PTGER4ENSP000003028464STRING: ENSP00000302846
    PTGIRENSP000002912944STRING: ENSP00000291294
    PTHENSP000002820914STRING: ENSP00000282091
    PTH1RENSP000003219994STRING: ENSP00000321999
    PTHLHENSP000003792134STRING: ENSP00000379213
    RXFP1ENSP000003032484STRING: ENSP00000303248
    RXFP2ENSP000002983864STRING: ENSP00000298386
    SCTENSP000001761954STRING: ENSP00000176195
    SCTRENSP000000191034STRING: ENSP00000019103
    SSTENSP000002876414STRING: ENSP00000287641
    SSTR3ENSP000003301384STRING: ENSP00000330138
    TSHRENSP000002981714STRING: ENSP00000298171
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCYAP1R1ENSP000003066204STRING: ENSP00000306620
    ADM2ENSP000003790864STRING: ENSP00000379086
    ADORA3ENSP000003587304STRING: ENSP00000358730
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    ADRA2CENSP000003860694STRING: ENSP00000386069
    ADRB3ENSP000003437824STRING: ENSP00000343782
    AGTR2ENSP000003609734STRING: ENSP00000360973
    ANXA1ENSP000002574974STRING: ENSP00000257497
    APLNENSP000003054644STRING: ENSP00000305464
    APLNRENSP000002572544STRING: ENSP00000257254
    APPENSP000002849814STRING: ENSP00000284981
    BDKRB1ENSP000002166294STRING: ENSP00000216629
    C3ENSP000002459074STRING: ENSP00000245907
    C3AR1ENSP000003020794STRING: ENSP00000302079
    C5ENSP000002236424STRING: ENSP00000223642
    C5AR1ENSP000003471974STRING: ENSP00000347197
    CALCBENSP000003460174STRING: ENSP00000346017
    CCL16ENSP000002932754STRING: ENSP00000293275
    CCL19ENSP000003088154STRING: ENSP00000308815
    CCL20ENSP000003516714STRING: ENSP00000351671
    CCL21ENSP000002596074STRING: ENSP00000259607
    CCL25ENSP000003750864STRING: ENSP00000375086
    CCL27ENSP000002596314STRING: ENSP00000259631
    CCL28ENSP000003544164STRING: ENSP00000354416
    CCL5ENSP000002932724STRING: ENSP00000293272
    CCR1ENSP000002961404STRING: ENSP00000296140
    CCR3ENSP000003500034STRING: ENSP00000350003
    CCR5ENSP000002923034STRING: ENSP00000292303
    CCR6ENSP000003393934STRING: ENSP00000339393
    CCR7ENSP000002466574STRING: ENSP00000246657
    CCR8ENSP000003264324STRING: ENSP00000326432
    CHRM4ENSP000004093784STRING: ENSP00000409378
    CXCL1ENSP000003791104STRING: ENSP00000379110
    CXCL10ENSP000003056514STRING: ENSP00000305651
    CXCL11ENSP000003068844STRING: ENSP00000306884
    CXCL13ENSP000002867584STRING: ENSP00000286758
    CXCL16ENSP000002937784STRING: ENSP00000293778
    CXCL3ENSP000002960264STRING: ENSP00000296026
    CXCL5ENSP000002960274STRING: ENSP00000296027
    CXCL6ENSP000002263174STRING: ENSP00000226317
    CXCL9ENSP000003549014STRING: ENSP00000354901
    CXCR1ENSP000002956834STRING: ENSP00000295683
    CXCR2ENSP000003196354STRING: ENSP00000319635
    CXCR5ENSP000002921744STRING: ENSP00000292174
    CXCR6ENSP000003044144STRING: ENSP00000304414
    DRD4ENSP000001761834STRING: ENSP00000176183
    DRD5ENSP000003061294STRING: ENSP00000306129
    EDN1ENSP000003686834STRING: ENSP00000368683
    EDNRAENSP000003150114STRING: ENSP00000315011
    ENSG00000234674ENSP000004015484STRING: ENSP00000401548
    ENSG00000236949ENSP000004165994STRING: ENSP00000416599
    ENSG00000258947ENSP000003202954STRING: ENSP00000320295
    ENTPD1ENSP000003602484STRING: ENSP00000360248
    ENTPD2ENSP000003472134STRING: ENSP00000347213
    ENTPD3ENSP000003018254STRING: ENSP00000301825
    ENTPD8ENSP000003605614STRING: ENSP00000360561
    FPR1ENSP000003027074STRING: ENSP00000302707
    FPR2ENSP000003401914STRING: ENSP00000340191
    FPR3ENSP000003418214STRING: ENSP00000341821
    FSHRENSP000003847084STRING: ENSP00000384708
    GALENSP000002656434STRING: ENSP00000265643
    GALR1ENSP000002997274STRING: ENSP00000299727
    GHRHENSP000002375274STRING: ENSP00000237527
    GHRHRENSP000003201804STRING: ENSP00000320180
    GIPRENSP000002632814STRING: ENSP00000263281
    GLP1RENSP000003623534STRING: ENSP00000362353
    GLP2RENSP000002624414STRING: ENSP00000262441
    GNAI2ENSP000003129994STRING: ENSP00000312999
    GNALENSP000003340514STRING: ENSP00000334051
    GNAO1ENSP000002624934STRING: ENSP00000262493
    GNAZENSP000002489964STRING: ENSP00000248996
    GNG11ENSP000002485644STRING: ENSP00000248564
    GNG12ENSP000003600214STRING: ENSP00000360021
    GNG13ENSP000002481504STRING: ENSP00000248150
    GNG2ENSP000003344484STRING: ENSP00000334448
    GNG3ENSP000002941174STRING: ENSP00000294117
    GNG4ENSP000003555564STRING: ENSP00000355556
    GNG7ENSP000003715944STRING: ENSP00000371594
    GNG8ENSP000003008734STRING: ENSP00000300873
    GPER1ENSP000002974694STRING: ENSP00000297469
    GPR17ENSP000002726444STRING: ENSP00000272644
    GPR18ENSP000003434284STRING: ENSP00000343428
    GPR55ENSP000003758934STRING: ENSP00000375893
    HCAR2ENSP000003750664STRING: ENSP00000375066
    HEBP1ENSP000000149304STRING: ENSP00000014930
    HRH3ENSP000003425604STRING: ENSP00000342560
    HRH4ENSP000002569064STRING: ENSP00000256906
    HTR1AENSP000003162444STRING: ENSP00000316244
    HTR1BENSP000003589634STRING: ENSP00000358963
    HTR1DENSP000003136614STRING: ENSP00000313661
    HTR4ENSP000003539154STRING: ENSP00000353915
    HTR5AENSP000002879074STRING: ENSP00000287907
    HTR6ENSP000002897534STRING: ENSP00000289753
    HTR7ENSP000003379494STRING: ENSP00000337949
    IAPPENSP000002406524STRING: ENSP00000240652
    ITPAENSP000003694564STRING: ENSP00000369456
    LHCGRENSP000002949544STRING: ENSP00000294954
    LPAR1ENSP000003517554STRING: ENSP00000351755
    LPAR2ENSP000003846654STRING: ENSP00000384665
    LPAR3ENSP000003596434STRING: ENSP00000359643
    MC4RENSP000002997664STRING: ENSP00000299766
    MCHR1ENSP000002490164STRING: ENSP00000249016
    MCHR2ENSP000002818064STRING: ENSP00000281806
    MTNR1AENSP000003028114STRING: ENSP00000302811
    MTNR1BENSP000002570684STRING: ENSP00000257068
    NME1ENSP000000130344STRING: ENSP00000013034
    NME1-NME2ENSP000003768864STRING: ENSP00000376886
    NME3ENSP000002193024STRING: ENSP00000219302
    NME4ENSP000002194794STRING: ENSP00000219479
    NME5ENSP000002651914STRING: ENSP00000265191
    NME6ENSP000004166584STRING: ENSP00000416658
    NME7ENSP000003567854STRING: ENSP00000356785
    NMSENSP000003660614STRING: ENSP00000366061
    NMUENSP000002642184STRING: ENSP00000264218
    NMUR1ENSP000003058774STRING: ENSP00000305877
    NMUR2ENSP000002552624STRING: ENSP00000255262
    NPBENSP000003327664STRING: ENSP00000332766
    NPBWR1ENSP000003302844STRING: ENSP00000330284
    NPBWR2ENSP000003587834STRING: ENSP00000358783
    NPSENSP000003811054STRING: ENSP00000381105
    NPSR1ENSP000003528394STRING: ENSP00000352839
    NPWENSP000003300704STRING: ENSP00000330070
    NPY1RENSP000003546524STRING: ENSP00000354652
    NPY2RENSP000003325914STRING: ENSP00000332591
    NPY4RENSP000003634314STRING: ENSP00000363431
    NPY5RENSP000003393774STRING: ENSP00000339377
    NTPCRENSP000003555874STRING: ENSP00000355587
    OPRD1ENSP000002349614STRING: ENSP00000234961
    OPRK1ENSP000002655724STRING: ENSP00000265572
    OPRL1ENSP000003367644STRING: ENSP00000336764
    OPRM1ENSP000003946244STRING: ENSP00000394624
    OXER1ENSP000003679304STRING: ENSP00000367930
    PDE2AENSP000003349104STRING: ENSP00000334910
    PDE6AENSP000002552664STRING: ENSP00000255266
    PDE6BENSP000004202954STRING: ENSP00000420295
    PDE6CENSP000003605024STRING: ENSP00000360502
    PDE6DENSP000002876004STRING: ENSP00000287600
    PDE6HENSP000002663954STRING: ENSP00000266395
    PDE9AENSP000002915394STRING: ENSP00000291539
    PENKENSP000003242484STRING: ENSP00000324248
    PMCHENSP000003322254STRING: ENSP00000332225
    PNOCENSP000003019084STRING: ENSP00000301908
    POLR1AENSP000002638574STRING: ENSP00000263857
    POLR1BENSP000002633314STRING: ENSP00000263331
    POLR1CENSP000003614654STRING: ENSP00000361465
    POLR1EENSP000003670294STRING: ENSP00000367029
    POLR2AENSP000003149494STRING: ENSP00000314949
    POLR2BENSP000003127354STRING: ENSP00000312735
    POLR2CENSP000002192524STRING: ENSP00000219252
    POLR2DENSP000002726454STRING: ENSP00000272645
    POLR2EENSP000002155874STRING: ENSP00000215587
    POLR2FENSP000004038524STRING: ENSP00000403852
    POLR2GENSP000003017884STRING: ENSP00000301788
    POLR2HENSP000002962234STRING: ENSP00000296223
    POLR2IENSP000002218594STRING: ENSP00000221859
    POLR2JENSP000002926144STRING: ENSP00000292614
    POLR2J3ENSP000003686454STRING: ENSP00000368645
    POLR2KENSP000003428894STRING: ENSP00000342889
    POLR2LENSP000003241244STRING: ENSP00000324124
    POLR3AENSP000003614464STRING: ENSP00000361446
    POLR3BENSP000002283474STRING: ENSP00000228347
    POLR3CENSP000003345644STRING: ENSP00000334564
    POLR3DENSP000003030884STRING: ENSP00000303088
    POLR3EENSP000002998534STRING: ENSP00000299853
    POLR3FENSP000003668284STRING: ENSP00000366828
    POLR3GENSP000003820584STRING: ENSP00000382058
    POLR3GLENSP000003583204STRING: ENSP00000358320
    POLR3HENSP000003473454STRING: ENSP00000347345
    POLR3KENSP000002938604STRING: ENSP00000293860
    PPBPENSP000002960284STRING: ENSP00000296028
    PPYENSP000002259924STRING: ENSP00000225992
    PRKAR1BENSP000003534154STRING: ENSP00000353415
    PRKAR2AENSP000002655634STRING: ENSP00000265563
    PRKAR2BENSP000002657174STRING: ENSP00000265717
    PTGDRENSP000003034244STRING: ENSP00000303424
    PTGDR2ENSP000003328124STRING: ENSP00000332812
    PTGER3ENSP000003490034STRING: ENSP00000349003
    PTH2RENSP000002728474STRING: ENSP00000272847
    PYYENSP000003531984STRING: ENSP00000353198
    RXFP3ENSP000003287084STRING: ENSP00000328708
    RXFP4ENSP000003573014STRING: ENSP00000357301
    S1PR1ENSP000003054164STRING: ENSP00000305416
    S1PR3ENSP000003508784STRING: ENSP00000350878
    S1PR4ENSP000002461154STRING: ENSP00000246115
    S1PR5ENSP000003284724STRING: ENSP00000328472
    SSTR1ENSP000002673774STRING: ENSP00000267377
    SSTR2ENSP000003501984STRING: ENSP00000350198
    SSTR4ENSP000002550084STRING: ENSP00000255008
    SSTR5ENSP000002938974STRING: ENSP00000293897
    TAAR1ENSP000002752164STRING: ENSP00000275216
    VIPR1ENSP000003272464STRING: ENSP00000327246
    VIPR2ENSP000002621784STRING: ENSP00000262178
    GCH1ENSP000003788904STRING: ENSP00000378890
    GNAI1ENSP000003430274STRING: ENSP00000343027
    GNAI3ENSP000003588674STRING: ENSP00000358867
    GNB1ENSP000003678724STRING: ENSP00000367872
    GNB2ENSP000003052604STRING: ENSP00000305260
    GNB4ENSP000002325644STRING: ENSP00000232564
    GNB5ENSP000002618374STRING: ENSP00000261837
    GNG10ENSP000003634114STRING: ENSP00000363411
    GNG5ENSP000003596754STRING: ENSP00000359675
    GNGT1ENSP000002485724STRING: ENSP00000248572
    GNGT2ENSP000003004064STRING: ENSP00000300406
    MOCS1ENSP000003622824STRING: ENSP00000362282
    ADCY7ENSP000002542354STRING: ENSP00000254235
    GNA15ENSP000002629584STRING: ENSP00000262958
    GINS1ENSP000002624604STRING: ENSP00000262460
    UBCENSP000003448184STRING: ENSP00000344818
    CAP1ENSP000003618784STRING: ENSP00000361878
    CAP2ENSP000002299224STRING: ENSP00000229922
    CAPZA1ENSP000002631684STRING: ENSP00000263168
    CAPZA2ENSP000003549474STRING: ENSP00000354947
    PDE8AENSP000003114534STRING: ENSP00000311453
    PDE8BENSP000002649174STRING: ENSP00000264917
    PDE4AENSP000002704744STRING: ENSP00000270474
    PDE4BENSP000003321164STRING: ENSP00000332116
    PDE4CENSP000003476894STRING: ENSP00000347689
    PDE4DENSP000003848064STRING: ENSP00000384806
    SUGT1ENSP000003672084STRING: ENSP00000367208
    ITPR1ENSP000004059344STRING: ENSP00000405934
    ITPR2ENSP000003707444STRING: ENSP00000370744
    ITPR3ENSP000003634354STRING: ENSP00000363435
    NF1ENSP000003510154STRING: ENSP00000351015
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process IDA18403039
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    ADCY6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADCY6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    Selected HMDB Compounds for ADCY6 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 Novoseek inferred chemical compound relationships for ADCY6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 64.5 6 15683739 (2), 9841634 (1), 15225617 (1), 15885660 (1) (see all 5)
    dopamine 25.6 1 15683739 (1)



    ADCY6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADCY6 gene (2 alternative transcripts): 
    NM_015270.3  NM_020983.2  

    Unigene Cluster for ADCY6:

    Adenylate cyclase 6
    Hs.525401  [show with all ESTs]
    Unigene Representative Sequence: NM_015270
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000547260(uc010slw.1) ENST00000550422(uc001rsi.4 uc001rsj.4)
    ENST00000307885(uc001rsh.4) ENST00000552099 ENST00000548351 ENST00000552090
    ENST00000551435 ENST00000548820 ENST00000357869
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ADCY6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADCY6 (see all 69):
    hsa-miR-140-5p hsa-miR-323-3p hsa-miR-4254 hsa-miR-631 hsa-miR-1224-3p hsa-miR-128 hsa-miR-3138 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidADCY6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ADCY6
    Predesigned siRNA for gene silencing in human, mouse, rat ADCY6
    Clone
    Products:
         
    OriGene clones in human, mouse for ADCY6 (see all 13)
    OriGene ORF clones in mouse, rat for ADCY6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADCY6 (NM_020983)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ADCY6
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADCY6
      QuantiTect SYBR Green Assays in human, mouse, rat ADCY6
      QuantiFast Probe-based Assays in human, mouse, rat ADCY6

    Additional mRNA sequence: 

    AB007882.2 AF250226.1 AK294446.1 BX537664.1 U65474.1 

    11 DOTS entries:

    DT.99937161  DT.40108164  DT.91743387  DT.453565  DT.95333624  DT.100777803  DT.100730796  DT.100027161 
    DT.100777796  DT.102831861  DT.75111797 

    7 AceView cDNA sequences:

    BC064923 AB007882 BX537664 U65474 AF250226 NM_015270 NM_020983 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY6    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                                                                                                                    
    SP2:                                                                                      -                                             
    SP3:                                                                                                                                    


    ECgene alternative splicing isoforms for ADCY6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADCY6 expression in normal human tissues (normalized intensities)      ADCY6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGATGAAAG
    ADCY6 Expression
    About this image


    ADCY6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Kidney (Urinary System)
             Metanephros
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Colon (Gastrointestinal Tract)
     
     Adipose (Muscoskeletal System)
    ADCY6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCY6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525401
        Custom PCR Arrays for ADCY6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ADCY6
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADCY6
    QuantiTect SYBR Green Assays in human, mouse, rat ADCY6
    QuantiFast Probe-based Assays in human, mouse, rat ADCY6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of animals.

    Orthologs for ADCY6 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy61 , 5 adenylate cyclase 61, 5 88.56(n)1
    94.6(a)1
      15 (54.59 cM)5
    115121  NM_007405.21  NP_031431.21 
     985899945 
    chicken
    (Gallus gallus)
    Aves ADCY66
    adenylate cyclase 6
    93(a)
    1 ↔ 1
    AADN03023257.1(21-1344)
    lizard
    (Anolis carolinensis)
    Reptilia ADCY66
    adenylate cyclase 6
    77(a)
    1 ↔ 1
    2(94460752-94526698)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adcy61 adenylate cyclase 6 70.32(n)
    76.19(a)
      100493933  XM_002935120.2  XP_002935166.2 
    zebrafish
    (Danio rerio)
    Actinopterygii adcy6b1 adenylate cyclase 6b 70.34(n)
    73.6(a)
      560807  XM_002666490.2  XP_002666536.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta rut3 molting cycle (sensu Insecta) adenylate
    cyclase
    49(a)
    (best of 5)
      12F4   --


    ENSEMBL Gene Tree for ADCY6 (if available)
    TreeFam Gene Tree for ADCY6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ADCY6 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    7 SIMAP similar genes for ADCY6 using alignment to 2 protein entries:     ADCY6_HUMAN (see all proteins):
    ADCY5    ADCY1    ADCY3    ADCY2    ADCY4    ADCY8
    ADCY7

    ADCY6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADCY6 (see all 443)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs617388491,2
    C,F--46213184(+) AGCTAG/CCAGCA 1 -- us2k13Minor allele frequency- C:0.46NS WA 196
    rs1469761101,2
    --46213209(+) CACTCA/GGGGAC 1 -- us2k10--------
    rs1384051951,2
    --46213277(+) AGATGC/GGCAGC 1 -- us2k10--------
    rs357841841,2
    C--48996935(+) CCTAAT/-TTTTT 2 -- int11Minor allele frequency- -:0.50NA 2
    rs1906936821,2
    C--49160383(+) TTTCCC/TCTCCT 2 -- ut310--------
    rs1831529561,2
    --49160403(+) ACTAAC/TGAAGT 2 -- ut310--------
    rs1874443401,2
    --49160441(+) GAAGAC/TGCCCA 2 -- ut310--------
    rs1405592051,2
    C--49160514(+) GGGCA-/GGCAGTGC 2 -- cds10--------
    rs1926765191,2
    --49160546(+) CAAACC/GTAGCA 2 -- ut310--------
    rs1462317501,2
    --49160594(+) TCCAAA/GACAAA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ADCY6 (49159975 - 49182820 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADCY6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv826363CNV Gain20364138

    Human Gene Mutation Database (HGMD): ADCY6
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADCY6
    DNA2.0 Custom Variant and Variant Library Synthesis for ADCY6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 600294    OMIM disorders: --

    15 diseases for ADCY6:    About MalaCards
    precocious puberty    thyroid adenoma    adenoma    chondrodysplasia
    thyroiditis    dilated cardiomyopathy    cholera    colorectal cancer
    ataxia    neuronitis    endotheliitis    hiv-1
    pancreatitis    cerebritis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ADCY6:
    Cholera

    ADCY6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADCY6
    Human Genome Epidemiology (HuGE) Navigator: ADCY6 (3 documents)

    Export disorders for ADCY6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADCY6 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with ADCY6)
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    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Polymorphism of the type 6 adenylyl cyclase gene and cardiac hypertrophy. (PubMed id 14871025)1, 4 Ikoma E....Ishikawa Y. (J. Cardiovasc. Pharmacol. 2003)
    3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    4. Cloning and expression of human adenylyl cyclase type VI in normal thyroid tissues. (PubMed id 10978539)1, 2 Wicker R.... Suarez H.G. (Biochim. Biophys. Acta 2000)
    5. Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 9455477)1, 2 Ishikawa K.... Ohara O. (DNA Res. 1997)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    8. Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PubMed id 21228062)1 Bogard A.S....Ostrom R.S. (J. Pharmacol. Exp. Ther. 2011)
    9. PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression. (PubMed id 20861226)1 Desch M....Todorov V.T. (Mol. Endocrinol. 2010)
    10. Increased blood pressure and hyperdynamic cardiovascular responses in carriers of a common hyperfunctional variant of adenylyl cyclase 6. (PubMed id 20732959)1 Hodges G.J....Feldman R.D. (J. Pharmacol. Exp. Ther. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 112 HGNC: 237 AceView: ADCY6 Ensembl:ENSG00000174233 euGenes: HUgn112
    ECgene: ADCY6 Kegg: 112 H-InvDB: ADCY6

    (According to HUGE)
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    HUGE: KIAA0422

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADCY6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADCY6 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADCY6 gene:
    Search GeneIP for patents involving ADCY6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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