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ADCY6 Gene

protein-coding   GIFtS: 74

GC12M047446
adenylate cyclase 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
AC6 1, 2
DKFZp779F075 2
EC 4.6.1.1 3
KIAA0422 2, 3
Descriptions
ATP pyrophosphate-lyase 6 3
Adenylate cyclase type VI 3
Adenylyl cyclase 6 3
Ca(2+)-inhibitable adenylyl cyclase 3
adenylate cyclase 6 2
External Ids
HGNC: 2371
Entrez Gene: 1122
UniProtKB: O433063
Ensembl: ENSG000001742337
Search outside databases for aliases for ADCY6 gene

Previous GC identifers: GC12P061214 GC12M049170 GC12M048876

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ADCY6:
This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the
formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this
gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is
significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue.
Alternative splicing generates 2 transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306
Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)

Gene Wiki entry for ADCY6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the ADCY6 gene  

Entrez Gene cytogenetic band: 12q12-q13   Ensembl cytogenetic band:  12q13.12   HGNC cytogenetic band: 12q12-q13

ADCY6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M047446:     (about GC identifiers)

Start:
47,446,248 bp from pter
End:
47,469,087 bp from pter
Size:
22,840 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306 (See protein sequence)
Recommended Name: Adenylate cyclase type 6  
Size: 1168 amino acids; 130615 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9NR75
Alternative splicing: 2 isoforms:  O43306-1   O43306-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_056085.1  NP_066193.1  


    ENSEMBL proteins: 
    ENSP00000378636 ENSP00000311405 ENSP00000350536 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (ADCY6)
    Human Recombinant Proteins from Abnova (ADCY6)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020 membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for ADCY6: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for ADCY6
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (ADCY6), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibody for ADCY6

    Assays for ADCY6: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR009398 Aden_cycl-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS


       GeneDecks  ADCY6 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry O43306

    ProtoNet protein and cluster: O43306

    1 Blocks protein family: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ADCY6)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADCY6)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020983

                  Applied Biosystems Silencer® siRNAs for ADCY6

                  Sigma-Aldrich siRNA and siRNA Panels for ADCY6  
                         Sigma-Aldrich shRNA for ADCY6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for ADCY6
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015270
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015270
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_015270 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_015270

    UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306
    Function: Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Inhibition by calcium in the submicromolar concentration range (By similarity)
    Enzyme Number (IUBMB): EC 4.6.1.1 

    Genatlas biochemistry entry for ADCY6:
    adenylyl cyclase,type VI,ubiquitous

    3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Adcy6):

    homeostasis/metabolismmuscle

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287 magnesium ion binding IEA--
    GO:0004016 adenylate cyclase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    5/7 Invitrogen iPath™ Online BioAtlas - Pathways for ADCY6 (see all 7 ) (Maps provided by GeneGo):
     ATP metabolism
     cAMP signaling
     PKA signaling
     A2B Receptor: Action via G-alpha s. (map 2)
     Regulation of fatty acid metabolic enzymes FACL, ACADM, FASN and SCD via adenosin receptor activation

       GeneDecks  ADCY6 for the pathways selected above  
    About GeneDecksing

    5/10 Millipore Pathways for ADCY6 (see all 10 )
     Adenylate cyclase-activating neuropeptides
     Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
     Development Beta-adrenergic receptors signaling via cAMP
     Development A2A receptor signaling
     Signal transduction cAMP signaling

       GeneDecks  ADCY6 for the pathways selected above  
    About GeneDecksing

    5/24 Sigma-Aldrich "Your Favorite Gene" Pathways for  ADCY6  (Your Favorite Gene powered by Ingenuity) (see all 24
     Molecular Mechanisms of Cancer
     Cardiac &beta
     Purine Metabolism
     CDK5 Signaling
     CXCR4 Signaling

       GeneDecks  ADCY6 for the pathways selected above  
    About GeneDecksing

    5/6 Kegg Pathways  (Kegg details for ADCY6) (see all 6 ):
     hsa00230 Purine metabolism
     hsa04270 Vascular smooth muscle contraction
     hsa04540 Gap junction
     hsa04742 Taste transduction
     hsa04912 GnRH signaling pathway

       GeneDecks  ADCY6 for the pathways selected above  
    About GeneDecksing

    5/104 Interacting proteins for ADCY6 (ENSP000003114053 O433062) via UniProtKB, MINT, and/or STRING (see all 104 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATXN1P542532MINT-2856791
    GNASENSP000003022373STRING (score=.981)
    CALM3ENSP000002912953STRING (score=.945)
    GCGENSP000003646473STRING (score=.94)
    PLNENSP000003501323STRING (score=.931)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006171 cAMP biosynthetic process IEA--
    GO:0007242 intracellular signaling cascade IEA--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for ADCY6
    Sigma-Aldrich Small Molecules for ADCY6:
    Inhibitor

    Compounds for ADCY6 available from Tocris Bioscience
    CompoundAction CAS number
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    PACAP 1-38Potent stimulator of adenylyl cyclase
    ForskolinAdenylyl cyclase activator[66575-29-9]
    PACAP 1-27Potent stimulator of adenylyl cyclase[137061-48-4]
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (ADCY6)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (ADCY6)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_020983

                  Sigma-Aldrich siRNA and siRNA Panels for ADCY6  
                         Sigma-Aldrich shRNA for ADCY6  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_015270  NM_020983  

    REFSEQ mRNAs for ADCY6 gene (2 alternative transcripts): 

    NM_015270.3   NM_020983.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_015270  NM_020983  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015270
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015270
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_015270 

    Additional cDNA sequence: AK225224.1 

    11 DOTS entries:

    DT.99937161  DT.40108164  DT.91743387  DT.453565  DT.95333624  DT.100777803  DT.100730796  DT.100027161 
    DT.100777796  DT.102831861  DT.75111797 

    7 AceView cDNA sequences:

    AB007882 NM_015270 AF250226 BC064923 BX537664 NM_020983 U65474 

    highest scoring ESTs for ADCY6:

    AB007882 AF250226 BC064923 BU187098 CA487529 CN310640 NM_015270 NM_020983 U65474 AA039830 

    Unigene Clusters for ADCY6:

    Adenylate cyclase 6
    Hs.525401  [show with all ESTs], Hs.694408  [show with all ESTs]
    Unigene Representative Sequences: NM_015270, AK225224


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY6

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
    SP1:                                                                                                                                    
    SP2:                                                                                      -                                             
    SP3:                                                                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for ADCY6

    3 Ensembl transcripts including schematic representations:
    ENST00000395210  ENST00000307885  ENST00000357869  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    ADCY6 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for ADCY6

    1 / 2 / 3

    4 probe-sets matching ADCY6 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    39383_at2, 3 U95-A 1 1.00 1.00 0.46 0.91 AB007882 1.00 1.00 1.00 1

    69842_f_at2, 3 U95-D 684 0.38 0.01 0.68 1.09 AI766478 0.20 0.04 0.14 2

    209195_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF250226 0.80 1.00 0.91 1

    209195_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GAGATGAAAG

    SOURCE GeneReport for Unigene clusters: Hs.525401 Hs.694408

    Expression variation in blood from EXPOLDB for ADCY6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for ADCY6 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    Adcy61   -- adenylate cyclase 6 92.13(n)
    95.95(a)
    477625  XM_858156.1  XP_863249.1 
    chimpanzee
    (Pan troglodytes)
    ADCY61   -- adenylate cyclase 6 97.31(n)
    96.74(a)
    451866  XM_509033.2  XP_509033.2 
    cow
    (Bos taurus)
    ADCY61   -- adenylate cyclase 6 91.4(n)
    95.63(a)
    509936  XM_869639.2  XP_874732.2 
    rat
    (Rattus norvegicus)
    Adcy61   -- adenylate cyclase 6 87.62(n)
    93.48(a)
    25289  NM_012821.2  NP_036953.2 
    mouse
    (Mus musculus)
    Adcy61, 5 155
    adenylate cyclase 61, 5 88.56(n)1
    94.6(a)1
    115121  NM_007405.21  NP_031431.21 
     AK0780785  AK1222795  (see all 11)
    About this table        Species with no ortholog for ADCY6

    ENSEMBL Gene Tree for ADCY6
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for ADCY6 gene
    ADCY52  ADCY82  ADCY12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/97 NCBI SNPs in ADCY6 are shown (see all 97 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 47)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs111687421,2
    A,C,F,H47470338(+) CCTAGG/ATATCT 1 -- ng314Minor allele frequency- A:0.14EU EA WA 418
    rs71321801,2
    A,F,H47445877(+) TCAGGA/GTGGGA 2 -- ng514Minor allele frequency- G:0.18EU EA WA 404
    rs37300711,2
    C,F,H47455065(-) ACGTTG/TCCTGT 2 A/S mis1 ese38Minor allele frequency- T:0.01EU EA WA 838
    --
    rs24469981,2
    A,C47470891(+) gtggcA/Gggcac 1 -- ng310--------
    rs37299731,2
    H47448520(-) AAAGGG/CAACAT 2 -- ut314Minor allele frequency- C:0.00EU EA WA 418
    --
    rs111687381,2
    A47465478(+) CAGCCG/TGACCA 2 -- int1 ng310--------
    --
    rs111687371,2
    A47465420(+) ATCCCA/GGCACT 2 -- ng31 int10--------
    rs24534861,2
    A,C,F47463380(+) CCACCT/GGCCCG 2 A/A syn1 ese31Minor allele frequency- G:0.47EA 1424
    rs37300641,2
    C,F,H47462849(-) GTGAGC/TTACGT 2 S/S syn14Minor allele frequency- T:0.01EU EA WA 418
    rs37300681,2
    F,H47456576(-) GGGCGC/TGTGCA 2 R/R syn1 ese34Minor allele frequency- T:0.05EU EA WA 420
    About this table

    HapMap Linkage Disequilibrium images for ADCY6 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 600294

    Human Gene Mutation Database: ADCY6
    Genetic Association Database: ADCY6
    Human Genome Epidemiology Navigator: ADCY6 (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/43 PubMed articles for ADCY6 gene (see all 43 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 112 HGNC: 237 AceView: ADCY6 Ensembl:ENSG00000174233 euGenes: HUgn112
    ECgene: ADCY6 H-InvDB: ADCY6
    (According to HUGE)
    About This Section

    HUGE: KIAA0422
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for ADCY6 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for ADCY6:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for ADCY6-related products

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     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for ADCY6 Antibodies for ADCY6
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for ADCY6 Small molecules for ADCY6
     "Your Favorite Gene" Pathwaysfeedback


      
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     Drugs for ADCY6
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for ADCY6

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