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Aliases & Descriptions for ADCY6
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases AC6 1 , 2 DKFZp779F075 2 EC 4.6.1.1 3 KIAA0422 2 , 3
Descriptions ATP pyrophosphate-lyase 6 3 Adenylate cyclase type VI 3 Adenylyl cyclase 6 3 Ca(2+)-inhibitable adenylyl cyclase 3 adenylate cyclase 6 2
Search outside databases for aliases for ADCY6 genePrevious GC identifers: GC12P061214 GC12M049170 GC12M048876
Summaries for ADCY6 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for ADCY6 : This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes theformation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of thisgene is found in normal thyroid and brain tissues, as well as some tumors; and its expression issignificantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue.Alternative splicing generates 2 transcript variants. [provided by RefSeq] UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306 Function : Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)
Gene Wiki entry for ADCY6
Genomic Location for ADCY6
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the ADCY6 gene Entrez Gene cytogenetic band: 12q12-q13 Ensembl cytogenetic band: 12q13.12 HGNC cytogenetic band: 12q12-q13 ADCY6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12M047446:
(about GC identifiers )
Start:
47,446,248 bp from pter
End:
47,469,087 bp from pter
Size:
22,840 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000012.10 NT_029419.11 Proteins for ADCY6
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306 (See
protein sequence )Recommended Name: Adenylate cyclase type 6 Size : 1168 amino acids; 130615 Da
Cofactor : Binds 2 magnesium ions per subunit (By similarity)
Subcellular location : Membrane; Multi-pass membrane protein
Secondary accessions : Q9NR75Alternative splicing : 2 isoforms : O43306-1 O43306-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_056085.1 NP_066193.1 ENSEMBL proteins: ENSP00000378636 ENSP00000311405 ENSP00000350536 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016020 membrane
IEA -- GO:0016021 integral to membrane
IEA --
About this table Antibodies for ADCY6: Assays for ADCY6:
Protein
Domains/ Families for ADCY6(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O43306 ProtoNet protein and cluster: O43306
1 Blocks protein family : IPB009398 Adenylate cyclase-like UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306 Similarity : Belongs to the adenylyl cyclase class-4/guanylyl cyclase familySimilarity : Contains 2 guanylate cyclase domains
Gene Function for ADCY6
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020983 Applied Biosystems Silencer ® siRNAs for ADCY6 Sigma-Aldrich siRNA and siRNA Panels for ADCY6 Sigma-Aldrich shRNA for ADCY6 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015270                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015270                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_015270  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_015270 UniProtKB/Swiss-Prot: ADCY6_HUMAN, O43306 Function : Membrane-bound, calcium-inhibitable adenylyl cyclase (By similarity)Catalytic activity : ATP = 3',5'-cyclic AMP + diphosphateEnzyme regulation : Inhibition by calcium in the submicromolar concentration range (By similarity)Enzyme Number (IUBMB): EC 4.6.1.1
Genatlas biochemistry entry for ADCY6 :adenylyl cyclase,type VI,ubiquitous
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Adcy6) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0000287 magnesium ion binding
IEA -- GO:0004016 adenylate cyclase activity
IEA --
About this table
Pathways & Interactions for ADCY6
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/24 Sigma-Aldrich "Your Favorite Gene" Pathways for ADCY6 (Your Favorite Gene powered by Ingenuity) (see all 24
) 5/104 Interacting proteins for ADCY6 (ENSP00000311405 3 O43306 2 ) via UniProtKB, MINT, and/or STRING (see all 104
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006171 cAMP biosynthetic process
IEA -- GO:0007242 intracellular signaling cascade
IEA --
About this table
Drugs & Compounds for ADCY6 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Enzo Life Sciences drugs & compounds for ADCY6
Sigma-Aldrich Small Molecules for ADCY6:Inhibitor
Compounds for ADCY6 available from Tocris Bioscience Compound Action
CAS
number SQ 22536 Adenylyl cyclase inhibitor [17318-31-9] NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2] PACAP 1-38 Potent stimulator of adenylyl cyclase Forskolin Adenylyl cyclase activator [66575-29-9] PACAP 1-27 Potent stimulator of adenylyl cyclase [137061-48-4]
About this table
Transcripts for ADCY6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_020983 Sigma-Aldrich siRNA and siRNA Panels for ADCY6 Sigma-Aldrich shRNA for ADCY6 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_015270 NM_020983
REFSEQ mRNAs for ADCY6 gene (2 alternative transcripts): NM_015270.3 NM_020983.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_015270 NM_020983
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_015270                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_015270                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_015270  
Additional cDNA sequence: AK225224.1
11 DOTS entries : DT.99937161 DT.40108164 DT.91743387 DT.453565 DT.95333624 DT.100777803 DT.100730796 DT.100027161 DT.100777796 DT.102831861 DT.75111797
7 AceView cDNA sequences :AB007882 NM_015270 AF250226 BC064923 BX537664 NM_020983 U65474
highest scoring ESTs for ADCY6 :AB007882 AF250226 BC064923 BU187098 CA487529 CN310640 NM_015270 NM_020983 U65474 AA039830
Unigene Clusters for ADCY6: Adenylate cyclase 6 Hs.525401 [show with all ESTs ] , Hs.694408 [show with all ESTs ] Unigene Representative Sequences: NM_015270 , AK225224 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY6 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 SP1 :                                             SP2 :                             -                 SP3 :                                            
About this scheme ECgene alternative splicing isoforms for ADCY6 3 Ensembl transcripts including schematic representations : ENST00000395210
ENST00000307885
ENST00000357869
Expression for ADCY6
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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ADCY6 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for ADCY6 1 / 2 / 3
4 probe-sets matching ADCY6 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GAGATGAAAGSOURCE GeneReport for Unigene clusters: Hs.525401 Hs.694408 Expression variation in blood from EXPOLDB for ADCY6
Orthologs for ADCY6
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for ADCY6 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for ADCY6 ENSEMBL Gene Tree for ADCY6 Paralogs for ADCY6 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for ADCY6 gene ADCY5 2 ADCY8 2 ADCY1 2
SNPs/Variants for ADCY6 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for ADCY6 (up to first 250kb)
Disorders & Mutations for ADCY6
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 600294 Human Gene Mutation Database : ADCY6 Genetic Association Database: ADCY6 Human Genome Epidemiology Navigator: ADCY6 (1 document)
Medical News for ADCY6 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for ADCY6 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/43 PubMed articles for ADCY6 gene (see all 43
):
Search for ADCY6
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ADCY6
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing ADCY6
(According to HUGE )
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Specialized Databases showing ADCY6 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for ADCY6 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for ADCY6:
Tocris compounds for ADCY6
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