Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCY5 Gene

protein-coding   GIFtS: 65
GCID: GC03M122949

Adenylate Cyclase 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenylate Cyclase 51 2     EC 4.6.1.13 8
Adenylate Cyclase Type V2 3     AC52
Adenylyl Cyclase 52 3     FDFM2
ATP Pyrophosphate-Lyase 52 3     Adenylate Cyclase Type 52

External Ids:    HGNC: 2361   Entrez Gene: 1112   Ensembl: ENSG000001731757   OMIM: 6002935   UniProtKB: O956223   

Export aliases for ADCY5 gene to outside databases

Previous GC identifers: GC03M119766 GC03M124282 GC03M124323 GC03M124324 GC03M124486 GC03M120376


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCY5 Gene:
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G
protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded
protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase
A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth
weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been
observed for this gene. (provided by RefSeq, Dec 2010)

GeneCards Summary for ADCY5 Gene: 
ADCY5 (adenylate cyclase 5) is a protein-coding gene. Diseases associated with ADCY5 include familial dyskinesia and facial myokymia, and precocious puberty, and among its related super-pathways are PKA activation in glucagon signalling and DAG and IP3 signaling. GO annotations related to this gene include adenylate cyclase binding and protein heterodimerization activity. An important paralog of this gene is ADCY2.

UniProtKB/Swiss-Prot: ADCY5_HUMAN, O95622
Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase

summary for ADCY5 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCY5 gene promoter:
         E2F-4   NRSF form 1   E2F-2   NRSF form 2   CREB   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCY5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCY5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.1   Ensembl cytogenetic band:  3q21.1   HGNC cytogenetic band: 3q21.1

ADCY5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY5 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M122949:  view genomic region     (about GC identifiers)

Start:
123,001,143 bp from pter      End:
123,168,605 bp from pter
Size:
167,463 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADCY5_HUMAN, O95622 (See protein sequence)
Recommended Name: Adenylate cyclase type 5  
Size: 1261 amino acids; 138908 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subunit: Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1
Subcellular location: Membrane; Multi-pass membrane protein. Cell projection, cilium (By similarity)
Secondary accessions: B7Z8A6 Q7RTV7 Q8NFM3
Alternative splicing: 2 isoforms:  O95622-1   O95622-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADCY5: NX_O95622

Explore proteomics data for ADCY5 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by RAF1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95622

  • 4/41 DME Specific Peptides for ADCY5 (O95622) (see all 41)
     AGRIHIT  RGGPEHR  FHKIYIQ  TVNVASR 

    ADCY5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADCY5 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001186571.1  NP_899200.1  

    ENSEMBL proteins: 
     ENSP00000419361   ENSP00000418537   ENSP00000308685   ENSP00000420082   ENSP00000420252  
     ENSP00000417789  
    Reactome Protein details: O95622
    Human Recombinant Protein Products for ADCY5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADCY5
    GenScript Custom Purified and Recombinant Proteins Services for ADCY5
    Novus Biologicals ADCY5 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY5 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0072372primary cilium ISS--

    ADCY5 for ontologies           About GeneDecksing



    ADCY5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ADCY5
    GenScript Custom Superior Antibodies Services for ADCY5
    Novus Biologicals ADCY5 Antibodies
    Abcam antibodies for ADCY5
    Cloud-Clone Corp. Antibodies for ADCY5 
    Search ThermoFisher Antibodies for ADCY5
    Search LSBio for Antibodies for ADCY5 

    Assay Products for ADCY5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADCY5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADCY5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADCY5 
    Cloud-Clone Corp. CLIAs for ADCY5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC5 
    Adenylyl cyclases

    3 InterPro protein domains:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry O95622

    ProtoNet protein and cluster: O95622

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY5_HUMAN, O95622
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY5_HUMAN, O95622
    Function: This is a membrane-bound, calcium-inhibitable adenylyl cyclase
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation
    by RAF1 results in its activation

         Genatlas biochemistry entry for ADCY5:
    adenylyl cyclase,type V,ubiquitous

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity IEA--
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008179adenylate cyclase binding ISS--
         
    ADCY5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADCY5:
     Increased Salmonella enterica   Increased cilium length after  

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Adcy5):
     behavior/neurological  homeostasis/metabolism 

    ADCY5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADCY5: Adcy5tm1Plhn Adcy5tm1Yish

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADCY5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADCY5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY5
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY5 (see all 60):
    hsa-miR-4328 hsa-miR-507 hsa-miR-449a hsa-miR-374c hsa-miR-9 hsa-miR-133a hsa-miR-3908 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADCY5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADCY5
    Sirion Biotech Customized adenovirus for overexpression of ADCY5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADCY5 (see all 6)
    OriGene ORF clones in mouse, rat for ADCY5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADCY5 (NM_183357)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY5
    Sirion Biotech Customized lentivirus for stable overexpression of ADCY5 
                         Customized lentivirus expression plasmids for stable overexpression of ADCY5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADCY5
    Search LifeMap BioReagents cell lines for ADCY5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADCY5 About   (see all 56)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PKA activation in glucagon signalling
    PKA activation in glucagon signalling0.94
    Neurophysiological process PGE2-induced pain processing0.44
    PKA-mediated phosphorylation of CREB0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.38
    PKA activation0.94
    Development Role of Activin A in cell differentiation and proliferation0.33
    Regulation of CFTR gating (normal and CF)0.80
    Development Beta-adrenergic receptors signaling via cAMP0.32
    2Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.91
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.65
    PLC-gamma1 signalling0.94
    G-protein mediated events0.64
    Ca-dependent events0.93
    Phospholipase C-mediated cascade0.57
    3Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    4Adenylate cyclase activating pathway
    Adenylate cyclase activating pathway0.71
    Inhibition of adenylate cyclase pathway0.71
    Adenylate cyclase inhibitory pathway0.71
    LPA4-mediated signaling events0.67
    5Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    Estrogen signaling pathway0.34
    GnRH signaling pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/12 EMD Millipore Pathways for ADCY5 (see all 12)
        Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
    Adenylate cyclase-activating neuropeptides
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling

    5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY5 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    5/15 GeneGo (Thomson Reuters) Pathways for ADCY5 (see all 15)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    5/6 BioSystems Pathways for ADCY5 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events
    LPA4-mediated signaling events

    5/53        Reactome Pathways for ADCY5 (see all 53)
        PKA activation
    Signaling by EGFR in Cancer
    G alpha (z) signalling events
    Downstream signal transduction
    Signal Transduction

    2 PharmGKB Pathways for ADCY5
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    5/29         Kegg Pathways  (Kegg details for ADCY5) (see all 29):
        Purine metabolism
    Chemokine signaling pathway
    Oocyte meiosis
    Vascular smooth muscle contraction
    Gap junction


    ADCY5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/298 Interacting proteins for ADCY5 (O956223 ENSP000004193614) via UniProtKB, MINT, STRING, and/or I2D (see all 298)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2Q084623, ENSP000003429524I2D: score=3 STRING: ENSP00000342952
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    GNAI1P630963, ENSP000003430274I2D: score=2 STRING: ENSP00000343027
    PRKCAP172523, ENSP000002843844I2D: score=1 STRING: ENSP00000284384
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001973adenosine receptor signaling pathway IEA--
    GO:0006112energy reserve metabolic process TAS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    ADCY5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADCY5 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADCY5:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADCY5 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    10/11 HMDB Compounds for ADCY5 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 DrugBank Compounds for ADCY5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE-- --target--10592235
    Forskolin-- 64657-11-0target--10592235

    1 IUPHAR Ligand for ADCY5 (AC5)    About this table 
    LigandTypeActionAffinityPubmed IDs
    NKY80
    InhibitorInhibition11602596

    3 Novoseek inferred chemical compound relationships for ADCY5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 58.2 7 19846118 (2), 14724153 (1), 15550390 (1), 16527269 (1) (see all 6)
    dopamine 11.1 1 16943566 (1)
    nitric oxide 1.2 1 10781930 (1)

    Search CenterWatch for drugs/clinical trials and news about ADCY5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADCY5 gene (2 alternative transcripts): 
    NM_001199642.1  NM_183357.2  

    Unigene Cluster for ADCY5:

    Adenylate cyclase 5
    Hs.593292  [show with all ESTs]
    Unigene Representative Sequence: NM_183357
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462833(uc021xdd.1 uc003egg.2 uc003egh.2) ENST00000491190
    ENST00000478092 ENST00000309879 ENST00000474577 ENST00000466617(uc003egi.1)
    ENST00000468683 ENST00000483566 ENST00000476455 ENST00000470367
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY5
    8/60 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY5 (see all 60):
    hsa-miR-4328 hsa-miR-507 hsa-miR-449a hsa-miR-374c hsa-miR-9 hsa-miR-133a hsa-miR-3908 hsa-miR-3613-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADCY5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY5
    Clone
    Products:
         
    OriGene clones in human, mouse for ADCY5 (see all 6)
    OriGene ORF clones in mouse, rat for ADCY5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ADCY5 (NM_183357)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY5
    Sirion Biotech Customized lentivirus for stable overexpression of ADCY5 
                         Customized lentivirus expression plasmids for stable overexpression of ADCY5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCY5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY5

    Additional mRNA sequence: 

    AF497517.1 AK093840.1 AK098381.1 AK124691.1 AK294565.1 AK302711.1 AK303070.1 AK316488.1 
    BX647739.1 U65473.1 

    6 DOTS entries:

    DT.99985583  DT.111136  DT.97802548  DT.120909730  DT.95375838  DT.99968921 

    24/80 AceView cDNA sequences (see all 80):

    AA338981 AA042912 BI040156 BX111767 BM690037 BI040151 AA609785 AW471239 
    BF430935 AK124691 BM720734 AF497517 AK098381 AI923941 NM_183357 CF551855 
    U65473 BX642336 CA488920 Z39712 BK000371 AI693372 AI698142 AI669087 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCY5 expression in normal human tissues (normalized intensities)      ADCY5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATTGAAA
    ADCY5 Expression
    About this image


    ADCY5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
             ganglion/cranial   
     
     Heart (Cardiovascular System)    fully expand to see all 3 entries
             heart/ventricle   
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   

    See ADCY5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCY5

    SOURCE GeneReport for Unigene cluster: Hs.593292
        SABiosciences Expression via Pathway-Focused PCR Array including ADCY5: 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY5
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCY5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADCY5 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy51 , 5 adenylate cyclase 51, 5 90.28(n)1
    95.71(a)1
      16 (24.71 cM)5
    2241291  NM_001012765.41  NP_001012783.31 
     351556365 
    chicken
    (Gallus gallus)
    Aves ADCY51 adenylate cyclase 5 76.02(n)
    82.72(a)
      395340  NM_204631.1  NP_989962.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY56
    Uncharacterized protein
    88(a)
    1 ↔ 1
    1(79492168-79570603)
    zebrafish
    (Danio rerio)
    Actinopterygii adcy51 adenylate cyclase 5 73.9(n)
    79.66(a)
      562619  NM_001171585.1  NP_001165056.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG433731 CG43373 59.21(n)
    52(a)
      39835  NM_001104152.2  NP_001097622.2 
    worm
    (Caenorhabditis elegans)
    Secernentea acy-41 Protein ACY-4 49.22(n)
    41.77(a)
      178949  NM_072085.4  NP_504486.4 


    ENSEMBL Gene Tree for ADCY5 (if available)
    TreeFam Gene Tree for ADCY5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCY5 gene
    ADCY22  GUCY2D2  GUCY2C2  NPR12  GUCY2F2  ADCY82  GUCY1A22  ADCY72  
    ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    11 SIMAP similar genes for ADCY5 using alignment to 5 protein entries:     ADCY5_HUMAN (see all proteins):
    ADCY6    ADCY7    ADCY1    ADCY3    ADCY4    GUCY1A3
    ADCY8    GUCY1B3    ADCY2    NPR1    DKFZp686J099

    ADCY5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3825 SNPs in ADCY5 are shown (see all 3825)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0688214
    Dyskinesia, familial, with facial myokymia (FDFM)4--see VAR_0688212 A T mis40--------
    rs1439054231,2
    C--120488040(+) AGCCCA/GGGGGG 1 -- int10--------
    rs622624331,2
    C,F--120488255(+) AGCCCC/GGAGGT 1 -- int18Minor allele frequency- G:0.38NA CSA WA EA 367
    rs1161039271,2
    F--120488508(+) AAGCGG/AAGCCC 1 -- int11Minor allele frequency- A:0.06WA 118
    rs1486327751,2
    --120488523(+) GCTCTC/TGGGGC 1 -- int10--------
    rs1874974671,2
    --123000732(+) TGTTCA/CATGCC 2 -- ds50010--------
    rs1868220061,2
    C--123000768(+) GCATAC/TAAACA 2 -- ds50010--------
    rs729624821,2
    C,F--123000949(+) TGCTAT/CGGTCA 2 -- ds50014Minor allele frequency- C:0.37WA CSA 124
    rs729624851,2
    C,F--123001022(+) CCCCCA/GCTCAG 2 -- ds50012Minor allele frequency- G:0.15WA 120
    rs1452604431,2
    --123001047(+) CTCTGC/TGGCTC 2 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADCY5 (123001143 - 123168605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ADCY5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2627675CNV Insertion19546169
    nsv3976CNV Insertion18451855
    esv272701CNV Insertion20981092
    nsv829707CNV Loss17160897
    esv21931CNV Loss19812545
    nsv877395CNV Gain21882294
    nsv822229CNV Gain20364138
    nsv877396CNV Gain21882294


    Human Gene Mutation Database (HGMD): ADCY5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADCY5
    DNA2.0 Custom Variant and Variant Library Synthesis for ADCY5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600293    OMIM disorders: --

    UniProtKB/Swiss-Prot: ADCY5_HUMAN, O95622
  • Dyskinesia, familial, with facial myokymia (FDFM) [MIM:606703]: A disorder characterized by predominantly
    perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal
    and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life,
    but in some individuals, they may diminish in frequency and severity at older ages. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 16 diseases for ADCY5:    About MalaCards
    familial dyskinesia and facial myokymia    precocious puberty    thyroid adenoma    myokymia
    adenoma    chondrodysplasia    major depressive disorder    thyroiditis
    cholera    dilated cardiomyopathy    obesity    neuronitis
    colorectal cancer    pancreatitis    breast cancer    leukemia

    1 disease from the University of Copenhagen DISEASES database for ADCY5:
    Cholera

    ADCY5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADCY5
    Human Genome Epidemiology (HuGE) Navigator: ADCY5 (13 documents)

    Export disorders for ADCY5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCY5 gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with ADCY5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. (PubMed id 10481931)1, 2, 3 Raimundo S.... Wisser H. (1999)
    2. Evaluating the discriminative power of multi-trait ge netic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (2010)
    3. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and H HEX-IDE are associated with reduced birthweight. (PubMed id 20490451)1, 4 Andersson E.A....Pedersen O. (2010)
    4. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. (PubMed id 20081857)1, 4 Saxena R....Zhao J.H. (2010)
    5. New genetic loci implicated in fasting glucose homeos tasis and their impact on type 2 diabetes risk. (PubMed id 20081858)1, 4 Dupuis J....Zillikens M.C. (2010)
    6. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B lo ci are associated with reduced glucose-stimulated beta cell function in middle- aged Danish people. (PubMed id 20419449)1, 4 Boesgaard T.W....Borch-Johnsen K. (2010)
    7. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. (PubMed id 20372150)1, 4 Freathy R.M.... M.I. (2010)
    8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)1, 2 Muzny D.M....Gibbs R.A. (2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    10. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. (PubMed id 12503609)1, 2 Ludwig M.G. and Seuwen K. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 111 HGNC: 236 AceView: ADCY5 Ensembl:ENSG00000173175 euGenes: HUgn111
    ECgene: ADCY5 Kegg: 111 H-InvDB: ADCY5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCY5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADCY5 gene:
    Search GeneIP for patents involving ADCY5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Kits and Assays available from EMD Millipore
     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore small molecules (inhibitor) for ADCY5
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ADCY5  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADCY5  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADCY5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADCY5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADCY5   OriGene Custom Protein Services for ADCY5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADCY5
     QIAGEN SeqTarget long-range PCR primers for resequencing ADCY5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY5
     GenScript Custom Purified and Recombinant Proteins Services for ADCY5 GenScript cDNA clones with any tag delivered in your preferred vector for ADCY5
     GenScript Custom Assay Services for ADCY5 GenScript Custom Superior Antibodies Services for ADCY5
     GenScript Custom overexpressing Cell Line Services for ADCY5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADCY5 promoter
     Search Chromatin IP Primers for ADCY5
     RT2 qPCR Primer Assay in human, mouse, rat ADCY5
     Search GNC Networks for ADCY5
     SABiosciences PCR Arrays including human, mouse, rat ADCY5
     Tocris compounds for ADCY5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADCY5 antibodies
     ADCY5 proteins
     Antibodies for ADCY5
     See all of Abcam's Antibodies, Kits and Proteins for ADCY5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ADCY5
     Antibodies for ADCY5
     ELISAs for ADCY5
     CLIAs for ADCY5
     Search LifeMap BioReagents cell lines for ADCY5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY5
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ADCY5
     SwitchGear Promoter luciferase reporter plasmids for ADCY5
     Search ThermoFisher Antibodies for ADCY5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ADCY5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADCY5
    Customized:
     lentivirus for stable overexpression of ADCY5
     lentivirus expression plasmids for stable overexpression of ADCY5
     adenovirus for overexpression of ADCY5
     Search LSBio for Antibodies for ADCY5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADCY5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4