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Aliases for ADCY5 Gene

Aliases for ADCY5 Gene

  • Adenylate Cyclase 5 2 3
  • ATP Pyrophosphate-Lyase 5 3 4
  • Adenylate Cyclase Type V 3 4
  • Adenylyl Cyclase 5 3 4
  • EC 4 63
  • FDFM 3 6
  • Adenylate Cyclase Type 5 3
  • AC5 3

External Ids for ADCY5 Gene

Previous GeneCards Identifiers for ADCY5 Gene

  • GC03M119766
  • GC03M122949
  • GC03M124282
  • GC03M124323
  • GC03M124324
  • GC03M124486
  • GC03M120376

Summaries for ADCY5 Gene

Entrez Gene Summary for ADCY5 Gene

  • This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for ADCY5 Gene

ADCY5 (Adenylate Cyclase 5) is a Protein Coding gene. Diseases associated with ADCY5 include dyskinesia, familial, with facial myokymia and thyroid adenoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein heterodimerization activity and adenylate cyclase binding. An important paralog of this gene is NPR2.

UniProtKB/Swiss-Prot for ADCY5 Gene

  • This is a membrane-bound, calcium-inhibitable adenylyl cyclase

Tocris Summary for ADCY5 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY5 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY5 Gene

Genomics for ADCY5 Gene

Regulatory Elements for ADCY5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCY5 Gene

123,282,296 bp from pter
123,449,758 bp from pter
167,463 bases
Minus strand

Genomic View for ADCY5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY5 Gene

Proteins for ADCY5 Gene

  • Protein details for ADCY5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenylate cyclase type 5
    Protein Accession:
    Secondary Accessions:
    • B7Z8A6
    • Q7RTV7
    • Q8NFM3

    Protein attributes for ADCY5 Gene

    1261 amino acids
    Molecular mass:
    138908 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    • Part of a complex containing AKAP5, ADCY6, PDE4C and PKD2 (By similarity). Interacts with RAF1.

    Alternative splice isoforms for ADCY5 Gene


neXtProt entry for ADCY5 Gene

Proteomics data for ADCY5 Gene at MOPED

Post-translational modifications for ADCY5 Gene

Other Protein References for ADCY5 Gene

Antibody Products

Domains for ADCY5 Gene

Gene Families for ADCY5 Gene

Protein Domains for ADCY5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY5: view

Function for ADCY5 Gene

Molecular function for ADCY5 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type V,ubiquitous
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibition by calcium in the submicromolar concentration range (By similarity). Phosphorylation by RAF1 results in its activation.
UniProtKB/Swiss-Prot Function:
This is a membrane-bound, calcium-inhibitable adenylyl cyclase

Enzyme Numbers (IUBMB) for ADCY5 Gene

Gene Ontology (GO) - Molecular Function for ADCY5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004016 adenylate cyclase activity IEA --
GO:0005515 protein binding --
GO:0005524 ATP binding IEA --
GO:0008179 adenylate cyclase binding ISS --
genes like me logo Genes that share ontologies with ADCY5: view
genes like me logo Genes that share phenotypes with ADCY5: view

Animal Models for ADCY5 Gene

MGI Knock Outs for ADCY5:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY5

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for ADCY5 Gene

Localization for ADCY5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY5 Gene

Membrane; Multi-pass membrane protein. Cell projection, cilium.

Subcellular locations from

Jensen Localization Image for ADCY5 Gene COMPARTMENTS Subcellular localization image for ADCY5 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 1
cytosol 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADCY5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0072372 primary cilium ISS --
genes like me logo Genes that share ontologies with ADCY5: view

Pathways for ADCY5 Gene

SuperPathways for ADCY5 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G-Protein-Coupled Receptor Signaling PathwayFinder in human,mouse,rat

Gene Ontology (GO) - Biological Process for ADCY5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process IEA --
GO:0006833 water transport TAS --
genes like me logo Genes that share ontologies with ADCY5: view

Drugs for ADCY5 Gene

(2) Drugbank Compounds for ADCY5 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
444894 Target experimental
64657-11-0 47936 Target experimental

(5) Tocris Compounds for ADCY5 Gene

Compound Action Cas Number
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
PACAP 1-38 Potent stimulator of adenylyl cyclase [137061-48-4]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(11) HMDB Compounds for ADCY5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Ca
Cyclic AMP
  • 3'5'-Cyclic AMP
Cyclic GMP
  • 3',5'-Cyclic GMP
Guanosine triphosphate
  • 5'-GTP

(1) IUPHAR Ligand for ADCY5 Gene

Ligand Type Action Affinity Pubmed IDs
NKY80 Inhibitor Inhibition

(3) Novoseek inferred chemical compound relationships for ADCY5 Gene

Compound -log(P) Hits PubMed IDs
adenylate 58.2 7
dopamine 11.1 1
nitric oxide 1.2 1
genes like me logo Genes that share compounds with ADCY5: view

Transcripts for ADCY5 Gene

Unigene Clusters for ADCY5 Gene

Adenylate cyclase 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY5 Gene

No ASD Table

Relevant External Links for ADCY5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCY5 Gene

mRNA expression in normal human tissues for ADCY5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADCY5 Gene

This gene is overexpressed in Esophagus - Gastroesophageal Junction (4.2).

Protein differential expression in normal tissues for ADCY5 Gene

This gene is overexpressed in Breast (55.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCY5 Gene

SOURCE GeneReport for Unigene cluster for ADCY5 Gene Hs.593292

genes like me logo Genes that share expressions with ADCY5: view

Expression partners for ADCY5 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ADCY5 Gene

Orthologs for ADCY5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCY5 35
  • 92.53 (n)
  • 97.06 (a)
ADCY5 36
  • 95 (a)
(Canis familiaris)
Mammalia ADCY5 35
  • 91.22 (n)
  • 93.94 (a)
ADCY5 36
  • 97 (a)
(Mus musculus)
Mammalia Adcy5 35
  • 89.48 (n)
  • 94.29 (a)
Adcy5 16
Adcy5 36
  • 95 (a)
(Pan troglodytes)
Mammalia ADCY5 35
  • 99.29 (n)
  • 99.26 (a)
ADCY5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Adcy5 35
  • 89.51 (n)
  • 94.37 (a)
(Monodelphis domestica)
Mammalia ADCY5 36
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 69 (a)
-- 36
  • 68 (a)
(Gallus gallus)
Aves ADCY5 35
  • 75.77 (n)
  • 82.01 (a)
ADCY5 36
  • 82 (a)
(Anolis carolinensis)
Reptilia ADCY5 36
  • 88 (a)
(Danio rerio)
Actinopterygii adcy5 35
  • 74.08 (n)
  • 79.29 (a)
adcy5 36
  • 79 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002998 35
  • 59.17 (n)
  • 52.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43373 35
  • 59.8 (n)
  • 52.68 (a)
CG43373 36
  • 29 (a)
(Caenorhabditis elegans)
Secernentea acy-4 35
  • 49.31 (n)
  • 42.07 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
Species with no ortholog for ADCY5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADCY5 Gene

Gene Tree for ADCY5 (if available)
Gene Tree for ADCY5 (if available)

Paralogs for ADCY5 Gene

(11) SIMAP similar genes for ADCY5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY5: view

Variants for ADCY5 Gene

Sequence variations from dbSNP and Humsavar for ADCY5 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs9289222 -- 123,441,503(+) TCATC(C/T)ACCTA intron-variant
rs9289221 -- 123,440,567(+) TCTTC(A/C)TTTCT intron-variant
rs9289220 -- 123,434,050(+) AAGCC(A/G)TGCAT intron-variant
rs9289219 -- 123,433,679(+) TGAAT(A/G)CTACT intron-variant
rs9289218 -- 123,345,984(+) ACCAA(C/T)GAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY5 Gene

Variant ID Type Subtype PubMed ID
nsv3976 CNV Insertion 18451855
nsv877395 CNV Gain 21882294
esv272701 CNV Insertion 20981092
nsv829707 CNV Loss 17160897
nsv822229 CNV Gain 20364138
esv2627675 CNV Insertion 19546169
nsv877396 CNV Gain 21882294
esv21931 CNV Loss 19812545

Relevant External Links for ADCY5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY5 Gene

Disorders for ADCY5 Gene

(1) OMIM Diseases for ADCY5 Gene (600293)


  • Dyskinesia, familial, with facial myokymia (FDFM) [MIM:606703]: A disorder characterized by predominantly perioral and periorbital myokymia, and face, neck and upper limb dystonic/choreic movements. Initially paroxysmal and worsened by stress, the dyskinetic episodes become nearly constant by the end of the third decade of life, but in some individuals, they may diminish in frequency and severity at older ages. {ECO:0000269 PubMed:22782511}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ADCY5 Gene

Relevant External Links for ADCY5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADCY5: view

No data available for Novoseek inferred disease relationships and Genatlas for ADCY5 Gene

Publications for ADCY5 Gene

  1. Cloning and sequence of partial cDNAs encoding the human type V and VI adenylyl cyclases and subsequent RNA-quantification in various tissues. (PMID: 10481931) Raimundo S. … Wisser H. (Clin. Chim. Acta 1999) 2 3 4
  2. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. (PMID: 20372150) Freathy R.M. … McCarthy M.I. (Nat. Genet. 2010) 3 48
  3. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. (PMID: 20081858) Dupuis J. … Barroso I. (Nat. Genet. 2010) 3 48
  4. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 48
  5. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. (PMID: 12503609) Ludwig M.G. … Seuwen K. (J. Recept. Signal Transduct. 2002) 3 4

Products for ADCY5 Gene

Sources for ADCY5 Gene

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