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Aliases for ADCY4 Gene

Aliases for ADCY4 Gene

  • Adenylate Cyclase 4 2 3 5
  • Adenylate Cyclase Type IV 3 4
  • ATP Pyrophosphate-Lyase 4 3 4
  • Adenylyl Cyclase 4 3 4
  • EC 4.6.1.1 4 63
  • EC 4.6.1 63
  • AC4 3

External Ids for ADCY4 Gene

Previous GeneCards Identifiers for ADCY4 Gene

  • GC14M022160
  • GC14M018574
  • GC14M022777
  • GC14M023857
  • GC14M024787
  • GC14M004902

Summaries for ADCY4 Gene

Entrez Gene Summary for ADCY4 Gene

  • This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for ADCY4 Gene

ADCY4 (Adenylate Cyclase 4) is a Protein Coding gene. Among its related pathways are Platelet activation and HTLV-I infection. GO annotations related to this gene include phosphorus-oxygen lyase activity and adenylate cyclase activity. An important paralog of this gene is ADCY3.

UniProtKB/Swiss-Prot for ADCY4 Gene

  • Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Tocris Summary for ADCY4 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY4 Gene

Genomics for ADCY4 Gene

Regulatory Elements for ADCY4 Gene

Enhancers for ADCY4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADCY4 on UCSC Golden Path with GeneCards custom track

Promoters for ADCY4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADCY4 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ADCY4 gene promoter:

Genomic Location for ADCY4 Gene

Chromosome:
14
Start:
24,318,349 bp from pter
End:
24,335,093 bp from pter
Size:
16,745 bases
Orientation:
Minus strand

Genomic View for ADCY4 Gene

Genes around ADCY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY4 Gene

Proteins for ADCY4 Gene

  • Protein details for ADCY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFM4-ADCY4_HUMAN
    Recommended name:
    Adenylate cyclase type 4
    Protein Accession:
    Q8NFM4
    Secondary Accessions:
    • B3KV74
    • D3DS75
    • Q17R40
    • Q6ZTM6
    • Q96ML7

    Protein attributes for ADCY4 Gene

    Size:
    1077 amino acids
    Molecular mass:
    119794 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71270.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ADCY4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY4 Gene

Proteomics data for ADCY4 Gene at MOPED

Post-translational modifications for ADCY4 Gene

  • Glycosylation at Asn 697 and Asn 704
  • Modification sites at PhosphoSitePlus

Domains & Families for ADCY4 Gene

Gene Families for ADCY4 Gene

Protein Domains for ADCY4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFM4

UniProtKB/Swiss-Prot:

ADCY4_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two modules.
  • Contains 2 guanylate cyclase domains.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY4: view

Function for ADCY4 Gene

Molecular function for ADCY4 Gene

GENATLAS Biochemistry:
adenylate cyclase,type IV
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by forskolin. Insensitive to calcium/calmodulin. Stimulated by GNAS and by the G-protein beta and gamma subunit complex.
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.

Enzyme Numbers (IUBMB) for ADCY4 Gene

Gene Ontology (GO) - Molecular Function for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031683 G-protein beta/gamma-subunit complex binding IEA --
genes like me logo Genes that share ontologies with ADCY4: view
genes like me logo Genes that share phenotypes with ADCY4: view

Animal Models for ADCY4 Gene

MGI Knock Outs for ADCY4:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ADCY4 Gene

Localization for ADCY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY4 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY4 Gene COMPARTMENTS Subcellular localization image for ADCY4 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane ISS --
GO:0030425 dendrite IEA --
genes like me logo Genes that share ontologies with ADCY4: view

Pathways & Interactions for ADCY4 Gene

SuperPathways for ADCY4 Gene

Superpath Contained pathways
1 DAG and IP3 signaling
2 Interleukin-3, 5 and GM-CSF signaling
3 Circadian entrainment
4 Development Endothelin-1/EDNRA signaling
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with ADCY4: view

SIGNOR curated interactions for ADCY4 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006833 water transport TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with ADCY4: view

Drugs & Compounds for ADCY4 Gene

(11) Drugs for ADCY4 Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Pyruvic acid Approved Nutra 0
Forskolin Experimental Pharma Adenylyl cyclase activator 0
cyclic amp Experimental Pharma 0
Cyclic GMP Experimental Pharma 0

(5) Additional Compounds for ADCY4 Gene - From: Tocris and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
NKH 477
138605-00-2
PACAP 1-27
127317-03-7
PACAP 1-38
137061-48-4
SQ 22536
17318-31-9

(5) Tocris Compounds for ADCY4 Gene

Compound Action Cas Number
Forskolin Adenylyl cyclase activator 66575-29-9
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
PACAP 1-27 Potent stimulator of adenylyl cyclase 127317-03-7
PACAP 1-38 Potent stimulator of adenylyl cyclase 137061-48-4
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9

(1) ApexBio Compounds for ADCY4 Gene

Compound Action Cas Number
Forskolin 66575-29-9
genes like me logo Genes that share compounds with ADCY4: view

Transcripts for ADCY4 Gene

Unigene Clusters for ADCY4 Gene

Adenylate cyclase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
SP1: - - - - - -
SP2:
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for ADCY4 Gene

GeneLoc Exon Structure for
ADCY4
ECgene alternative splicing isoforms for
ADCY4

Expression for ADCY4 Gene

mRNA expression in normal human tissues for ADCY4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADCY4 Gene

This gene is overexpressed in Heart (45.0) and Placenta (24.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCY4 Gene



SOURCE GeneReport for Unigene cluster for ADCY4 Gene Hs.443428

mRNA Expression by UniProt/SwissProt for ADCY4 Gene

Q8NFM4-ADCY4_HUMAN
Tissue specificity: Detected in the zona glomerulosa and the zona fasciculata in the adrenal gland (at protein level).
genes like me logo Genes that share expression patterns with ADCY4: view

Protein tissue co-expression partners for ADCY4 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for ADCY4 Gene

Orthologs for ADCY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADCY4 35
  • 89.97 (n)
  • 93.48 (a)
ADCY4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY4 35
  • 89.31 (n)
  • 93.17 (a)
ADCY4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy4 35
  • 86.75 (n)
  • 92.72 (a)
Adcy4 16
Adcy4 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADCY4 35
  • 99.69 (n)
  • 99.72 (a)
ADCY4 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy4 35
  • 86.29 (n)
  • 92.44 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCY4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ADCY4 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy4 35
  • 63.46 (n)
  • 64.71 (a)
zebrafish
(Danio rerio)
Actinopterygii adcy2b 36
  • 52 (a)
ManyToMany
CABZ01111926.1 36
  • 70 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 37
  • 46 (a)
Ac76E 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea acy-2 37
  • 46 (a)
acy-4 37
  • 49 (a)
acy-2 36
  • 29 (a)
OneToMany
Species with no ortholog for ADCY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY4 Gene

ENSEMBL:
Gene Tree for ADCY4 (if available)
TreeFam:
Gene Tree for ADCY4 (if available)

Paralogs for ADCY4 Gene

Paralogs for ADCY4 Gene

genes like me logo Genes that share paralogs with ADCY4: view

Variants for ADCY4 Gene

Sequence variations from dbSNP and Humsavar for ADCY4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8003158 -- 24,333,057(+) AAGCC(A/G)GCAGC intron-variant
rs2877642 -- 24,328,238(+) GGGGG(G/T)GGGGT intron-variant
rs751877 -- 24,327,607(+) CCCCC(A/C/T)CTCCC intron-variant
rs8006514 -- 24,325,222(+) GGGCC(A/G)TGATT intron-variant
rs3078135 -- 24,326,913(+) TTTTT(-/TTT/TTTT/TTTTTTT)GCAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY4 Gene

Variant ID Type Subtype PubMed ID
dgv1855n71 CNV Loss 21882294
nsv516237 CNV Loss 19592680
esv272516 CNV Insertion 20981092

Variation tolerance for ADCY4 Gene

Residual Variation Intolerance Score: 16.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.37; 53.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADCY4 Gene

Disorders for ADCY4 Gene

Relevant External Links for ADCY4

Genetic Association Database (GAD)
ADCY4
Human Genome Epidemiology (HuGE) Navigator
ADCY4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY4

No disorders were found for ADCY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY4 Gene

Publications for ADCY4 Gene

  1. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) CA'tAc M. … Gallo-Payet N. (J. Clin. Endocrinol. Metab. 2001) 3 4 23 67
  2. Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. (PMID: 7766992) Edelhoff S. … Disteche C.M. (Mamm. Genome 1995) 2 3
  3. Genome-wide association analyses of child genotype effects and parent-of-origin effects in specific language impairment. (PMID: 24571439) Nudel R. … Newbury D.F. (Genes Brain Behav. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PMID: 21228062) Bogard A.S. … Ostrom R.S. (J. Pharmacol. Exp. Ther. 2011) 3

Products for ADCY4 Gene

Sources for ADCY4 Gene

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