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Aliases for ADCY4 Gene

Aliases for ADCY4 Gene

  • Adenylate Cyclase 4 2 3
  • Adenylate Cyclase Type IV 3 4
  • ATP Pyrophosphate-Lyase 4 3 4
  • Adenylyl Cyclase 4 3 4
  • EC 4.6.1.1 4 63
  • Adenylate Cyclase Type 4 3
  • EC 4.6.1 63
  • AC4 3

External Ids for ADCY4 Gene

Summaries for ADCY4 Gene

Entrez Gene Summary for ADCY4 Gene

  • This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

GeneCards Summary for ADCY4 Gene

ADCY4 (Adenylate Cyclase 4) is a Protein Coding gene. Diseases associated with ADCY4 include adenoma. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY4 Gene

  • This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

Tocris Summary for ADCY4 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5-triphosphate (ATP) into 3,5-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY4 Gene

Genomics for ADCY4 Gene

Genomic Location for ADCY4 Gene

Start:
24,318,349 bp from pter
End:
24,335,093 bp from pter
Size:
16,745 bases
Orientation:
Minus strand

Genomic View for ADCY4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY4 Gene

Regulatory Elements for ADCY4 Gene

Transcription factor binding sites by QIAGEN in the ADCY4 gene promoter:

Proteins for ADCY4 Gene

  • Protein details for ADCY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFM4-ADCY4_HUMAN
    Recommended name:
    Adenylate cyclase type 4
    Protein Accession:
    Q8NFM4
    Secondary Accessions:
    • B3KV74
    • D3DS75
    • Q17R40
    • Q6ZTM6
    • Q96ML7

    Protein attributes for ADCY4 Gene

    Size:
    1077 amino acids
    Molecular mass:
    119794 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71270.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ADCY4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY4 Gene

Proteomics data for ADCY4 Gene at MOPED

Post-translational modifications for ADCY4 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys267 and Lys1001
  • Glycosylation at Asn697 and Asn704

Other Protein References for ADCY4 Gene

Domains for ADCY4 Gene

Gene Families for ADCY4 Gene

HGNC:
  • ADCY :Adenylate cyclases
IUPHAR :

Protein Domains for ADCY4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8NFM4

UniProtKB/Swiss-Prot:

ADCY4_HUMAN
Domain:
  • Contains 2 guanylate cyclase domains.:
    • Q8NFM4
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.:
    • Q8NFM4
genes like me logo Genes that share domains with ADCY4: view

Function for ADCY4 Gene

Molecular function for ADCY4 Gene

GENATLAS Biochemistry: adenylate cyclase,type IV
UniProtKB/Swiss-Prot CatalyticActivity: ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By similarity).
UniProtKB/Swiss-Prot Function: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase.

Enzyme Numbers (IUBMB) for ADCY4 Gene

Gene Ontology (GO) - Molecular Function for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004016 adenylate cyclase activity ISS --
GO:0005515 protein binding IPI 17081159
GO:0005524 ATP binding IEA --
GO:0016849 phosphorus-oxygen lyase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADCY4: view

Phenotypes for ADCY4 Gene

genes like me logo Genes that share phenotypes with ADCY4: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADCY4 Gene

Localization for ADCY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY4 Gene COMPARTMENTS Subcellular localization image for ADCY4 gene
Compartment Confidence
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 11549699
GO:0005886 plasma membrane TAS --
GO:0016020 membrane ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCY4: view

Pathways for ADCY4 Gene

SuperPathways for ADCY4 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY4: view

Gene Ontology (GO) - Biological Process for ADCY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process ISS --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY4: view

Compounds for ADCY4 Gene

(5) Tocris Compounds for ADCY4 Gene

Compound Action Cas Number
KH 7 Selective soluble adenylyl cyclase inhibitor [330676-02-3]
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(11) HMDB Compounds for ADCY4 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
Cyclic GMP
  • 3',5'-cyclic GMP
7665-99-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ADCY4: view

Transcripts for ADCY4 Gene

Unigene Clusters for ADCY4 Gene

Adenylate cyclase 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:

ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
SP1: - - - - - -
SP2:
SP3: - - - - - - -
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: -
SP11:

Relevant External Links for ADCY4 Gene

GeneLoc Exon Structure for
ADCY4
ECgene alternative splicing isoforms for
ADCY4

Expression for ADCY4 Gene

mRNA expression in normal human tissues for ADCY4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCY4 Gene

SOURCE GeneReport for Unigene cluster for ADCY4 Gene Hs.443428

genes like me logo Genes that share expressions with ADCY4: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADCY4 Gene

Orthologs for ADCY4 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY4 35
  • 99.69 (n)
  • 99.72 (a)
ADCY4 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCY4 35
  • 89.97 (n)
  • 93.48 (a)
ADCY4 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY4 35
  • 89.31 (n)
  • 93.17 (a)
ADCY4 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy4 35
  • 86.75 (n)
  • 92.72 (a)
Adcy4 16
Adcy4 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCY4 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 50 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Adcy4 35
  • 86.29 (n)
  • 92.44 (a)
lizard
(Anolis carolinensis)
Reptilia ADCY4 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adcy4 35
  • 63.46 (n)
  • 64.71 (a)
zebrafish
(Danio rerio)
Actinopterygii adcy2b 36
  • 52 (a)
ManyToMany
CABZ01111926.1 36
  • 70 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 36
  • 31 (a)
OneToMany
Ac76E 37
  • 46 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-2 36
  • 29 (a)
OneToMany
acy-2 37
  • 46 (a)
acy-4 37
  • 49 (a)
Species with no ortholog for ADCY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY4 Gene

ENSEMBL:
Gene Tree for ADCY4 (if available)
TreeFam:
Gene Tree for ADCY4 (if available)

Paralogs for ADCY4 Gene

genes like me logo Genes that share paralogs with ADCY4: view

Variants for ADCY4 Gene

Sequence variations from dbSNP and Humsavar for ADCY4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs726702 -- 24,320,429(-) TGCTA(C/G)AAAGC intron-variant
rs751877 -- 24,327,607(+) CCCCC(A/C)CTCCC intron-variant
rs882726 -- 24,328,791(+) AGACC(A/C)ACCGA intron-variant
rs1109152 -- 24,329,818(-) CCAAC(C/G)AGGCC intron-variant
rs1109153 -- 24,330,081(-) GAATC(A/T)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY4 Gene

Variant ID Type Subtype PubMed ID
dgv1855n71 CNV Loss 21882294
nsv516237 CNV Loss 19592680
esv272516 CNV Insertion 20981092

Relevant External Links for ADCY4 Gene

HapMap Linkage Disequilibrium report
ADCY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY4 Gene

Disorders for ADCY4 Gene

(1) MalaCards Diseases for ADCY4 Gene

Search for ADCY4 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ADCY4 Gene

Relevant External Links for ADCY4

Genetic Association Database (GAD)
ADCY4
Human Genome Epidemiology (HuGE) Navigator
ADCY4
genes like me logo Genes that share disorders with ADCY4: view

No data available for UniProtKB/Swiss-Prot for ADCY4 Gene

Publications for ADCY4 Gene

  1. Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. (PMID: 7766992) Edelhoff S. … Disteche C.M. (Mamm. Genome 1995) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) CA'tAc M. … Gallo-Payet N. (J. Clin. Endocrinol. Metab. 2001) 3 23
  4. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. (PMID: 12503609) Ludwig M.G. … Seuwen K. (J. Recept. Signal Transduct. 2002) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ADCY4 Gene

Sources for ADCY4 Gene

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