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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCY4 Gene

protein-coding   GIFtS: 65
GCID: GC14M024787

Adenylate Cyclase 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenylate Cyclase 41 2     EC 4.6.1.13 8
Adenylate Cyclase Type IV2 3     AC42
Adenylyl Cyclase 42 3     Adenylate Cyclase Type 42
ATP Pyrophosphate-Lyase 42 3     EC 4.6.18

External Ids:    HGNC: 2351   Entrez Gene: 1968832   Ensembl: ENSG000001294677   OMIM: 6002925   UniProtKB: Q8NFM43   

Export aliases for ADCY4 gene to outside databases

Previous GC identifers: GC14M022160 GC14M018574 GC14M022777 GC14M023857 GC14M004902


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCY4 Gene:
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that
catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that
adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that
several different adenylate cyclases may couple to olfactory receptors and that there may be multiple
receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript
variants. (provided by RefSeq, Nov 2010)

GeneCards Summary for ADCY4 Gene: 
ADCY4 (adenylate cyclase 4) is a protein-coding gene. Diseases associated with ADCY4 include precocious puberty, and thyroid adenoma, and among its related super-pathways are PKA activation in glucagon signalling and DAG and IP3 signaling. GO annotations related to this gene include adenylate cyclase activity and metal ion binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY4_HUMAN, Q8NFM4
Function: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)

summary for ADCY4 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCY4 gene promoter:
         AML1a   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCY4 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCY4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q12   Ensembl cytogenetic band:  14q12   HGNC cytogenetic band: 14q11.2

ADCY4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M024787:  view genomic region     (about GC identifiers)

Start:
24,787,555 bp from pter      End:
24,804,299 bp from pter
Size:
16,745 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADCY4_HUMAN, Q8NFM4 (See protein sequence)
Recommended Name: Adenylate cyclase type 4  
Size: 1077 amino acids; 119794 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAB71270.1; Type=Erroneous initiation;
Secondary accessions: B3KV74 D3DS75 Q17R40 Q96ML7

Explore the universe of human proteins at neXtProt for ADCY4: NX_Q8NFM4

Explore proteomics data for ADCY4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NFM4

  • 4/14 DME Specific Peptides for ADCY4 (Q8NFM4) (see all 14)
     WQYDVWS  ASRMEST  ADIVGFT  TVNVASR 

    ADCY4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADCY4 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001185497.1  NP_001185521.1  NP_640340.2  

    ENSEMBL proteins: 
     ENSP00000312126   ENSP00000450481   ENSP00000452250   ENSP00000450477   ENSP00000393177  
     ENSP00000450843   ENSP00000453259   ENSP00000453893   ENSP00000379971  
    Reactome Protein details: Q8NFM4
    Human Recombinant Protein Products for ADCY4: 
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    OriGene Custom Protein Services for ADCY4
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY4 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11549699
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ISS--
    GO:0016021integral to membrane IEA--

    ADCY4 for ontologies           About GeneDecksing



    ADCY4 Antibody Products: 
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    Novus Biologicals ADCY4 Antibodies
    Abcam antibodies for ADCY4
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    ThermoFisher Antibodies for ADCY4
    LSBio Antibodies in human, mouse, rat for ADCY4 

    Assay Products for ADCY4: 
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    Cloud-Clone Corp. ELISAs for ADCY4 
    Cloud-Clone Corp. CLIAs for ADCY4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC4 
    Adenylyl cyclases

    3 InterPro protein domains:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q8NFM4

    ProtoNet protein and cluster: Q8NFM4

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY4_HUMAN, Q8NFM4
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY4_HUMAN, Q8NFM4
    Function: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase (By similarity)
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex
    (By similarity)

         Genatlas biochemistry entry for ADCY4:
    adenylate cyclase,type IV

         Enzyme Numbers (IUBMB): EC 4.6.1.11 2 EC 4.6.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity ISS--
    GO:0005515protein binding IPI17081159
    GO:0005524ATP binding IEA--
    GO:0016849phosphorus-oxygen lyase activity ----
         
    ADCY4 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADCY4:
     Increased cell number in G1, s  Upregulation of Wnt/beta-caten 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Adcy4):
     normal 

    ADCY4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADCY4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADCY4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY4 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): ADCY4 (NM_001198592)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY4
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADCY4 About   (see all 54)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PKA activation in glucagon signalling
    PKA activation in glucagon signalling0.94
    Neurophysiological process PGE2-induced pain processing0.44
    PKA-mediated phosphorylation of CREB0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.38
    PKA activation0.94
    Development Role of Activin A in cell differentiation and proliferation0.33
    Regulation of CFTR gating (normal and CF)0.80
    Development Beta-adrenergic receptors signaling via cAMP0.32
    2Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.91
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.65
    PLC-gamma1 signalling0.94
    G-protein mediated events0.64
    Ca-dependent events0.93
    Phospholipase C-mediated cascade0.57
    3Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    4Adenylate cyclase activating pathway
    Adenylate cyclase activating pathway0.71
    Inhibition of adenylate cyclase pathway0.71
    Adenylate cyclase inhibitory pathway0.71
    LPA4-mediated signaling events0.67
    5Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    Estrogen signaling pathway0.34
    GnRH signaling pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/9 EMD Millipore Pathways for ADCY4 (see all 9)
        Adenylate cyclase-activating neuropeptides
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling

    5/23 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY4 (see all 23)
        MAPK Signaling
    PKA Signaling
    Molecular Mechanisms of Cancer
    Relaxin Pathway
    G-AlphaI Signaling

    5/12 GeneGo (Thomson Reuters) Pathways for ADCY4 (see all 12)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    5/6 BioSystems Pathways for ADCY4 (see all 6)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events
    LPA4-mediated signaling events

    5/50        Reactome Pathways for ADCY4 (see all 50)
        PKA activation
    Signaling by EGFR in Cancer
    G alpha (z) signalling events
    Downstream signal transduction
    Signal Transduction

    2 PharmGKB Pathways for ADCY4
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    5/26         Kegg Pathways  (Kegg details for ADCY4) (see all 26):
        Purine metabolism
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Vascular smooth muscle contraction


    ADCY4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/294 Interacting proteins for ADCY4 (ENSP000003121264) via UniProtKB, MINT, STRING, and/or I2D (see all 294)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY1ENSP000002973234STRING: ENSP00000297323
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process ISS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    ADCY4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for ADCY4:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADCY4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    10/11 HMDB Compounds for ADCY4 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    Search CenterWatch for drugs/clinical trials and news about ADCY4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADCY4 gene (3 alternative transcripts): 
    NM_001198568.1  NM_001198592.1  NM_139247.3  

    Unigene Cluster for ADCY4:

    Adenylate cyclase 4
    Hs.443428  [show with all ESTs]
    Unigene Representative Sequence: NM_001198568
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000310677(uc001wox.3 uc001woy.3 uc001wow.3 uc010toh.2)
    ENST00000557056 ENST00000555684 ENST00000554577 ENST00000554068 ENST00000545213
    ENST00000554781 ENST00000418030 ENST00000561200 ENST00000560635 ENST00000554936
    ENST00000554959 ENST00000556932 ENST00000554674 ENST00000557099(uc001woz.4)
    ENST00000559167 ENST00000558563 ENST00000558125
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY4
    Sirion Biotech Customized lentivirus for stable overexpression of ADCY4 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY4

    Additional mRNA sequence: 

    AF088070.1 AF497516.1 AK056745.1 AK122714.1 BC015982.2 BC117473.1 BC117475.1 BC143947.1 
    BX248285.1 

    15 DOTS entries:

    DT.311014  DT.100021034  DT.101983233  DT.101983234  DT.95100821  DT.311015  DT.100841983  DT.91929244 
    DT.120775192  DT.120775194  DT.120775214  DT.99949530  DT.100746324  DT.92051428  DT.92425143 

    24/159 AceView cDNA sequences (see all 159):

    BQ007090 AK122714 AK131333 BI765026 AW085656 BI819557 BI838468 AL045027 
    NM_139247 CA305961 AI000839 AI394293 NM_006871 BI833736 CA310192 AA044828 
    BQ880215 AA054849 AF086230 CD370547 AW207417 BE857103 AK075275 CA308180 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY4 (see all 11)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
    SP1:                    -                                         -                                         -                                                   
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                        -                 -                                 
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b ^ 19a · 19b ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b
    SP1:  -           -                 -     -     -           -                                             
    SP2:                                                                                                      
    SP3:  -           -           -     -     -     -           -                                             
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for ADCY4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCY4 expression in normal human tissues (normalized intensities)      ADCY4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCCCTACAG
    ADCY4 Expression
    About this image


    ADCY4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 10 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Renal Glomerular Endothelial Cells (HRGEC)   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
             Human Brain Microvascular Endothelial Cells (HBMEC)   
             brain/midbrain   
     
     Heart (Cardiovascular System)    fully expand to see all 4 entries
             Primitive Heart Tube Cells Primitive Heart Tube
             heart/ventricle   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             PureStem endothelial progenitor 30-MV2-12
             mouse/organ system/cardiovascular system   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 3 entries
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   

    See ADCY4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCY4

    SOURCE GeneReport for Unigene cluster: Hs.443428
        SABiosciences Custom PCR Arrays for ADCY4
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADCY4 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy41 , 5 adenylate cyclase 41, 5 86.75(n)1
    92.72(a)1
      14 (28.19 cM)5
    1041101  NM_080435.11  NP_536683.11 
     557690925 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY46
    adenylate cyclase 4
    65(a)
    1 ↔ 1
    GL343220.1(543233-601328)
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01111926.16
    CABZ01109105.16
    Uncharacterized protein
    70(a)
    49(a)
    possible ortholog
    possible ortholog
    7(1583566-1585989)
    7(770598-778158)
    fruit fly
    (Drosophila melanogaster)
    Insecta Ac76E3 adenylate cyclase 46(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea acy-43   -- 49(a)
    (best of 2)
      V(5627531-5629064)   --


    ENSEMBL Gene Tree for ADCY4 (if available)
    TreeFam Gene Tree for ADCY4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCY4 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  GUCY2F2  ADCY82  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  NPR22  ADCY32  
    11 SIMAP similar genes for ADCY4 using alignment to 8 protein entries:     ADCY4_HUMAN (see all proteins):
    ADCY2    ADCY9    NPR1    ADCY7    ADCY3    ADCY6
    ADCY5    ADCY8    ADCY1    GUCY2C    GUCY1B3

    ADCY4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/549 SNPs in ADCY4 are shown (see all 549)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs768272401,2
    C,F--24787778(-) CAATTG/TTAGGT 3 -- int11Minor allele frequency- T:0.00EU 1323
    rs773763111,2
    C--24787788(-) CGCCCC/TCCTCC 3 -- int10--------
    rs1996199311,2
    --24787833(+) CTCCCC/GCTATG 3 -- int10--------
    rs1503919391,2
    C,F--24787936(+) ATTGCG/TGCTTC 6 Q P mis12Minor allele frequency- T:0.00NA EU 5875
    rs1170266781,2
    --24788113(+) TGGAGG/AAATGT 3 -- int11Minor allele frequency- A:0.01EA 120
    rs22953031,2
    C--24788220(-) CTGCTC/TCCAGT 3 -- int15Minor allele frequency- T:0.16EA NA WA 1780
    rs2013175261,2
    --24788254(+) CAAGCG/TCAGGA 3 -- int10--------
    rs617416401,2
    C,F--24788316(+) CAGGCG/AGAAGT 6 /R /C mis12Minor allele frequency- A:0.00NS NA 4588
    rs2005829691,2
    --24788322(+) GAAGTC/TGTTGA 6 N D mis10--------
    rs1995869781,2
    --24788324(+) AGTTGC/TTGAAT 6 N S mis10--------

    HapMap Linkage Disequilibrium report for ADCY4 (24787555 - 24804299 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADCY4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv272516CNV Insertion20981092
    nsv516237CNV Loss19592680
    dgv1855n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600292    OMIM disorders: --

    11 diseases for ADCY4:    About MalaCards
    precocious puberty    thyroid adenoma    adenoma    chondrodysplasia
    thyroiditis    cholera    dilated cardiomyopathy    neuronitis
    colorectal cancer    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ADCY4:
    Cholera

    ADCY4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADCY4
    Human Genome Epidemiology (HuGE) Navigator: ADCY4 (2 documents)

    Export disorders for ADCY4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCY4 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with ADCY4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. (PubMed id 12503609)1, 2 Ludwig M.G. and Seuwen K. (2002)
    4. Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. (PubMed id 7766992)1, 3 Edelhoff S....Disteche C.M. (1995)
    5. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PubMed id 11549699)1, 9 Cote M....Gallo-Payet N. (2001)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PubMed id 21228062)1 Bogard A.S....Ostrom R.S. (2011)
    9. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (2010)
    10. Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts. (PubMed id 17081159)1 Rhim J.H....Park S.C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 196883 HGNC: 235 AceView: RIPK3andADCY4 Ensembl:ENSG00000129467 euGenes: HUgn196883
    ECgene: ADCY4 Kegg: 196883 H-InvDB: ADCY4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCY4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADCY4 gene:
    Search GeneIP for patents involving ADCY4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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