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Aliases for ADCY3 Gene

Aliases for ADCY3 Gene

  • Adenylate Cyclase 3 2 3
  • Adenylate Cyclase, Olfactive Type 3 4
  • Adenylate Cyclase Type III 3 4
  • ATP Pyrophosphate-Lyase 3 3 4
  • Adenylyl Cyclase 3 3 4
  • EC 4 63
  • AC-III 3 4
  • AC3 3 4
  • Adenylyl Cyclase, Type III 3
  • Adenylate Cyclase Type 3 3
  • KIAA0511 4
  • EC 4.6.1 63

External Ids for ADCY3 Gene

Previous GeneCards Identifiers for ADCY3 Gene

  • GC02M024963
  • GC02M025134
  • GC02M024999
  • GC02M025016
  • GC02M024953
  • GC02M025042
  • GC02M024779

Summaries for ADCY3 Gene

Entrez Gene Summary for ADCY3 Gene

  • This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY3 Gene

ADCY3 (Adenylate Cyclase 3) is a Protein Coding gene. Diseases associated with ADCY3 include thyroid adenoma and precocious puberty. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include calmodulin binding and adenylate cyclase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY3 Gene

  • Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration

Tocris Summary for ADCY3 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC; nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8 are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications, phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and chondrodysplasia.

Gene Wiki entry for ADCY3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY3 Gene

Genomics for ADCY3 Gene

Regulatory Elements for ADCY3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCY3 Gene

24,819,169 bp from pter
24,919,839 bp from pter
100,671 bases
Minus strand

Genomic View for ADCY3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY3 Gene

Proteins for ADCY3 Gene

  • Protein details for ADCY3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Adenylate cyclase type 3
    Protein Accession:
    Secondary Accessions:
    • B3KT86
    • Q53T54
    • Q9UDB1

    Protein attributes for ADCY3 Gene

    1144 amino acids
    Molecular mass:
    128960 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADCY3 Gene


neXtProt entry for ADCY3 Gene

Proteomics data for ADCY3 Gene at MOPED

Selected DME Specific Peptides for ADCY3 Gene

Post-translational modifications for ADCY3 Gene

  • Ubiquitination at Lys1046, Lys1111, and Lys1120
  • Glycosylation at Asn736
  • Modification sites at PhosphoSitePlus

Other Protein References for ADCY3 Gene

Antibody Products

Domains for ADCY3 Gene

Gene Families for ADCY3 Gene

Protein Domains for ADCY3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
  • Contains 2 guanylate cyclase domains.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY3: view

Function for ADCY3 Gene

Molecular function for ADCY3 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type III,calmodulin sensitive,olfactory sensory neurons,brain,spinal and retina,heart,kidney,liver,lung,pancreas,placenta,skeletal muscle
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by calcium/calmodulin
UniProtKB/Swiss-Prot Function:
Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration

Enzyme Numbers (IUBMB) for ADCY3 Gene

Gene Ontology (GO) - Molecular Function for ADCY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0004016 adenylate cyclase activity IEA --
GO:0005515 protein binding --
GO:0005516 calmodulin binding IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ADCY3: view
genes like me logo Genes that share phenotypes with ADCY3: view

Animal Models for ADCY3 Gene

MGI Knock Outs for ADCY3:

Animal Model Products

miRNA for ADCY3 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ADCY3 Gene

Localization for ADCY3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADCY3 Gene COMPARTMENTS Subcellular localization image for ADCY3 gene
Compartment Confidence
plasma membrane 4
cytosol 1

Gene Ontology (GO) - Cellular Components for ADCY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11549699
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 9920776
GO:0005929 cilium IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ADCY3: view

Pathways for ADCY3 Gene

SuperPathways for ADCY3 Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Circadian entrainment
4 Activation of cAMP-Dependent PKA
5 Regulation of Water Balance by Renal Aquaporins
genes like me logo Genes that share pathways with ADCY3: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ADCY3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process IEA --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY3: view

Drugs for ADCY3 Gene

(5) Tocris Compounds for ADCY3 Gene

Compound Action Cas Number
MDL 12330A hydrochloride Adenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor [40297-09-4]
NKH 477 Water-soluble adenylyl cyclase activator [138605-00-2]
PACAP 1-27 Potent stimulator of adenylyl cyclase [127317-03-7]
PACAP 1-38 Potent stimulator of adenylyl cyclase [137061-48-4]
SQ 22536 Adenylyl cyclase inhibitor [17318-31-9]

(1) ApexBio Compounds for ADCY3 Gene

Compound Action Cas Number
Forskolin [66575-29-9]

(11) HMDB Compounds for ADCY3 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
  • Ca
Cyclic AMP
  • 3'5'-Cyclic AMP
Cyclic GMP
  • 3',5'-Cyclic GMP
Guanosine triphosphate
  • 5'-GTP

(7) Novoseek inferred chemical compound relationships for ADCY3 Gene

Compound -log(P) Hits PubMed IDs
cyclic amp 53.7 1
forskolin 52.8 3
adenylate 44.3 6
gtp 33.4 1
calcium 31.5 17
genes like me logo Genes that share compounds with ADCY3: view

Transcripts for ADCY3 Gene

Unigene Clusters for ADCY3 Gene

Adenylate cyclase 3:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^
SP1: -
SP2: -
SP5: -
SP10: - -
SP11: - -
SP12: -

ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
SP3: -
SP4: - -

Relevant External Links for ADCY3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCY3 Gene

mRNA expression in normal human tissues for ADCY3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for ADCY3 Gene

This gene is overexpressed in Lung (44.6), Esophagus (10.8), and Heart (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCY3 Gene

SOURCE GeneReport for Unigene cluster for ADCY3 Gene Hs.467898

mRNA Expression by UniProt/SwissProt for ADCY3 Gene

Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle
genes like me logo Genes that share expressions with ADCY3: view

Expression partners for ADCY3 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADCY3 Gene

Orthologs for ADCY3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCY3 35
  • 90.62 (n)
  • 94.76 (a)
ADCY3 36
  • 94 (a)
(Canis familiaris)
Mammalia ADCY3 35
  • 90.36 (n)
  • 93.88 (a)
ADCY3 36
  • 93 (a)
(Mus musculus)
Mammalia Adcy3 35
  • 89.99 (n)
  • 94.75 (a)
Adcy3 16
Adcy3 36
  • 94 (a)
(Pan troglodytes)
Mammalia ADCY3 35
  • 99.53 (n)
  • 99.74 (a)
ADCY3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Adcy3 35
  • 89.34 (n)
  • 94.65 (a)
(Monodelphis domestica)
Mammalia ADCY3 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia ADCY3 36
  • 86 (a)
(Gallus gallus)
Aves ADCY3 35
  • 79.14 (n)
  • 80.44 (a)
ADCY3 36
  • 80 (a)
(Anolis carolinensis)
Reptilia ADCY3 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dnajc27 35
  • 75.25 (n)
  • 80.81 (a)
(Danio rerio)
Actinopterygii adcy3l 35
  • 73.85 (n)
  • 77.34 (a)
ADCY3 36
  • 77 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ac3 37
  • 37 (a)
Ac78C 37
  • 38 (a)
Ac3 35
  • 51.2 (n)
  • 43.95 (a)
Ac3 36
  • 38 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009315 35
  • 55.35 (n)
  • 43.78 (a)
(Caenorhabditis elegans)
Secernentea acy-4 37
  • 45 (a)
Species with no ortholog for ADCY3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCY3 Gene

Gene Tree for ADCY3 (if available)
Gene Tree for ADCY3 (if available)

Paralogs for ADCY3 Gene

genes like me logo Genes that share paralogs with ADCY3: view

Variants for ADCY3 Gene

Sequence variations from dbSNP and Humsavar for ADCY3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7603153 -- 24,894,097(+) tcata(C/T)ctctt intron-variant
rs7602614 -- 24,858,031(+) ggtcc(C/T)gctgt intron-variant
rs7602276 -- 24,857,716(+) actgg(C/T)ggaaa intron-variant
rs7600421 -- 24,853,007(+) GAGGG(G/T)GTGTG intron-variant
rs7599796 -- 24,887,353(+) ttggg(C/T)gggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY3 Gene

Variant ID Type Subtype PubMed ID
nsv508831 CNV Insertion 20534489
nsv873742 CNV Loss 21882294
esv2678377 CNV Deletion 23128226
nsv2645 CNV Loss 18451855
esv2666034 CNV Deletion 23128226
esv2668898 CNV Deletion 23128226
esv2673418 CNV Deletion 23128226
nsv2646 CNV Insertion 18451855
esv989967 CNV Deletion 20482838
nsv524979 CNV Loss 19592680

Relevant External Links for ADCY3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY3 Gene

Disorders for ADCY3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ADCY3 Gene in MalaCards »

(3) Diseases for ADCY3 Gene

(1) University of Copenhagen DISEASES for ADCY3 Gene

Relevant External Links for ADCY3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADCY3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for ADCY3 Gene

Publications for ADCY3 Gene

  1. Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets. (PMID: 9920776) Yang B. … Hillert J. (Biochem. Biophys. Res. Commun. 1999) 2 3 4 23
  2. Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. (PMID: 17895882) Nordman S. … Gu H.F. (Int J Obes (Lond) 2008) 3 23 48
  3. Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules. (PMID: 12782409) Celano M. … Russo D. (Mol. Cell. Endocrinol. 2003) 3 23
  4. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) CA'tAc M. … Gallo-Payet N. (J. Clin. Endocrinol. Metab. 2001) 3 23
  5. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 3 4

Products for ADCY3 Gene

Sources for ADCY3 Gene

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