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ADCY3 Gene

protein-coding GIFtS: 66

GC02M024953

adenylate cyclase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AC-III ^³
AC3 ^¹, ², ³
EC 4.6.1.1 ^³
KIAA0511 ^², ³

Descriptions
ATP pyrophosphate-lyase ^²
ATP pyrophosphate-lyase 3 ^³
Adenylate cyclase type III ^³
Adenylate cyclase, olfactive type ^³
Adenylyl cyclase 3 ^³
adenylate cyclase 3 ^²
adenylyl cyclase, type III ^²

External Ids
HGNC: 234¹
Entrez Gene: 109²
UniProtKB: O60266³
Ensembl: ENSG00000138031⁷

Search outside databases for aliases for ADCY3 gene

Previous GC identifers: GC02M024963 GC02M025134 GC02M024999 GC02M025016

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADCY3:

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the

formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears

to be widely expressed in various human tissues and may be involved in a number of physiological

and pathophysiological metabolic processes. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266

Function: Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration

Gene Wiki entry for ADCY3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADCY3 gene

Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p24-p22

ADCY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M024953: (about GC identifiers)

Start:	24,895,542 bp from pter
End:	24,995,559 bp from pter
Size:	100,018 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266 (See protein sequence)

Recommended Name: Adenylate cyclase type 3

Size: 1144 amino acids; 128960 Da

Cofactor: Binds 2 magnesium ions per subunit (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q53T54 Q9UDB1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004027.2

ENSEMBL proteins:

ENSP00000384484 ENSP00000260600

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ADCY3)
	Human Recombinant Proteins from Abnova (ADCY3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	9920776
GO:0005887	integral to plasma membrane	TAS	9920776
GO:0045121	membrane raft	IEA	--

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Antibodies for ADCY3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ADCY3), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ADCY3

Assays for ADCY3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O60266

ProtoNet protein and cluster: O60266

UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266

Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family

Similarity: Contains 2 guanylate cyclase domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADCY3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADCY3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004036

Applied Biosystems Silencer® siRNAs for ADCY3

Sigma-Aldrich siRNA and siRNA Panels for ADCY3

Sigma-Aldrich shRNA for ADCY3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004036
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004036
untagged cDNA clone in CMV expression vector: NM_004036

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004036

UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266

Function: Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration

Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate

Enzyme regulation: Activated by calcium/calmodulin

Enzyme Number (IUBMB): EC 4.6.1.1

Genatlas biochemistry entry for ADCY3:

adenylyl cyclase,type III,calmodulin sensitive,olfactory sensory neurons,brain,spinal and

retina,heart,kidney,liver,lung,pancreas,placenta,skeletal muscle

6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Adcy3):

growth/size	lethality-postnatal	nervous system	normal	reproductive system
taste/olfaction

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0005516	calmodulin binding	IEA	--
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/24 Sigma-Aldrich "Your Favorite Gene" Pathways for ADCY3 (Your Favorite Gene powered by Ingenuity) (see all 24 )

Synaptic Long Term Depression
Cardiac Hypertrophy Signaling
Molecular Mechanisms of Cancer
Relaxin Signaling
&alpha

GeneDecks ADCY3 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for ADCY3

5/111 Interacting proteins for ADCY3 (ENSP00000260600³) via UniProtKB, MINT, and/or STRING (see all 111 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GCG	ENSP00000364647³	STRING (score=.94)
CALM3	ENSP00000291295³	STRING (score=.936)
GNAS	ENSP00000302237³	STRING (score=.925)
EDN1	ENSP00000368683³	STRING (score=.919)
ADCY1	ENSP00000297323³	STRING (score=.917)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006171	cAMP biosynthetic process	IEA	--
GO:0007143	female meiosis	IEA	--
GO:0007242	intracellular signaling cascade	IEA	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADCY3

Sigma-Aldrich Small Molecules for ADCY3:

Inhibitor

Compounds for ADCY3 available from Tocris Bioscience

Compound	Action	CAS number
SQ 22536	Adenylyl cyclase inhibitor	[17318-31-9]
NKH 477	Water-soluble adenylyl cyclase activator	[138605-00-2]
PACAP 1-38	Potent stimulator of adenylyl cyclase
Forskolin	Adenylyl cyclase activator	[66575-29-9]
PACAP 1-27	Potent stimulator of adenylyl cyclase	[137061-48-4]

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5 Novoseek chemical compound relationships for ADCY3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
forskolin	53.76	3	9751186 (1), 7680573 (1), 7592612 (1)
cyclic amp	48.27	1	1633161 (1)
gtp	34.67	1	9218142 (1)
calcium	30.81	24	7665559 (5), 1633161 (4), 8997178 (1), 11549699 (1) (see all 9)
hydrogen	0.00	1	11756511 (1)

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2 PharmGKB drug compound relationships for ADCY3 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
mercaptopurine	PD FA GN	12704389
methotrexate	PD FA GN	12704389

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADCY3)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADCY3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004036

Sigma-Aldrich siRNA and siRNA Panels for ADCY3

Sigma-Aldrich shRNA for ADCY3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004036

REFSEQ mRNAs for ADCY3 gene:

NM_004036.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004036

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004036
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004036
                                 untagged cDNA clone in CMV expression vector: NM_004036

Additional cDNA sequence:

AB011083.1 AF033861.1 AK027857.1 AK075424.1 AK095173.1 AK122926.1 BC020148.1 BC126235.1

BC144119.1

16 DOTS entries:

DT.219077 DT.100819432 DT.120940672 DT.91826761 DT.100042120 DT.100819430 DT.92451457 DT.100819425

DT.120940603 DT.120940609 DT.120940625 DT.95240075 DT.97822531 DT.101977950 DT.92451454 DT.95349064

24/212 AceView cDNA sequences (see all 212 ):

BM464344 AI342153 AI431333 AA252998 BI767655 AU124073 AI422294 AI126382

BQ223470 AI696614 AV725329 AA464193 AI565545 AW166397 AA278862 W68610

AA399222 CB852792 AI083759 BQ082039 AA620918 CB154258 AI567467 BQ716966

highest scoring ESTs for ADCY3:

AB011083 AF033861 AW821356 AA157697 AA279346 AA323254 AA323466 AA324932 AA429582 AA894421

Unigene Cluster for ADCY3:

Adenylate cyclase 3

Hs.467898 [show with all ESTs]

Unigene Representative Sequence: NM_004036

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY3 (see all 15 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^
SP1:																									-
SP2:																																									-
SP3:
SP4:
SP5:																																									-

ExUns:	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23	^	24a	·	24b	^	25
SP1:
SP2:
SP3:															-
SP4:															-										-
SP5:

About this scheme

ECgene alternative splicing isoforms for ADCY3

2 Ensembl transcripts including schematic representations:

ENST00000405392 ENST00000260600

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ADCY3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADCY3

¹ / ² / ³

5 probe-sets matching ADCY3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33134_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AB011083	1.00	1.00	1.00	1
209320_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF033861	0.80	1.00	0.91	1
209321_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF033861	0.80	1.00	0.91	1
209320_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209321_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ADCY3 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGAACAGAAA

SOURCE GeneReport for Unigene cluster: Hs.467898
Expression variation in blood from EXPOLDB for ADCY3
UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and
skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADCY3 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ADCY8¹	--	adenylate cyclase 8 (brain)	90.24(n) 93.79(a)	482994 XM_540108.2 XP_540108.2
chimpanzee (Pan troglodytes)	ADCY8¹	--	adenylate cyclase 8 (brain)	99.53(n) 99.74(a)	459070 XM_001146938.1 XP_001146938.1
cow (Bos taurus)	ADCY3¹	--	similar to type III adenylyl cyclase	90.62(n) 94.76(a)	535603 XM_615710.3 XP_615710.3
rat (Rattus norvegicus)	Adcy3¹	--	adenylate cyclase 3	89.28(n) 94.65(a)	64508 NM_130779.1 NP_570135.1
mouse (Mus musculus)	Adcy3^{1, 5}	12⁵	adenylate cyclase 3^{1, 5}	89.9(n)¹ 94.48(a)¹	104111¹ NM_138305.2¹ NP_612178.1¹ AF253540⁵ AF458089⁵ (see all 13)

About this table Species with no ortholog for ADCY3

ENSEMBL Gene Tree for ADCY3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADCY3 gene

ADCY9²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/686 NCBI SNPs in ADCY3 are shown (see all 686 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 221)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11676272^1,2	A,C,F,H	24995042(+)	`GAGGGG/AAGCCA`	1	P/S	mis¹ ese³		5		NA EU EA WA	458
	rs13021319^1,2	H	24995311(+)	`CGGCTG/AAGTAC`	1	L/S	mis¹ ese³		4		EU EA WA	418
	rs1127568^1,2	A,C,F,H,O	24899594(-)	`ATCTCA/GGATTT`	1	S/S	syn¹ ese³		17		EA NA EU WA	2916
	rs2241759^1,2	A,C,F,H	24917697(+)	`TAGTCA/GGGCAA`	1	P/P	syn¹ ese³		11		EA EU WA NA	2498
	rs2241758^1,2	C,F	24917661(+)	`CCCATG/CAGGAT`	1	L/L	syn¹ ese³		1		EA	1482
	rs7566416^1,2	A,C	24904481(+)	`TCCGTC/TTCCAT`	1	E/E	syn¹ ese³		0	--	--	--	--
	rs4275988^1,2	H	24918034(+)	`GCAAAG/AAGGAT`	1	L/L	syn¹		4		EU EA WA	416
	rs2033654^1,2	A,C,F,H,O	24956612(-)	`GACCTT/GGCCTA`	1	--	int¹		15		NA EA MN EU WA	1416
	rs2033653^1,2	A,C,F,H,O	24956950(-)	`CTTACG/ATTTGA`	1	--	int¹		12		EU EA WA NA	1054
	rs1865689^1,2	A,C,F,H,O	24961701(-)	`CCGCCG/ATAAGG`	1	--	int¹		15		NA EU EA WA	1400

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HapMap Linkage Disequilibrium images for ADCY3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600291

1 PharmGKB disease relationship for ADCY3 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	PD FA GN	12086872 12704389 12730115

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Human Genome Epidemiology Navigator: ADCY3 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/81 PubMed articles for ADCY3 gene (see all 81 ):

Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets. (PubMed id 9920776)^{1, 2, 3, 4} Yang B.... Hillert J. (1999)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{3, 4} Nagase T....Ohara O. (1998)
A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line. (PubMed id 8476432)^{3, 4} Hellevuo K....Tabakoff B. (1993)
Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. (PubMed id 17895882)^{1, 3} Nordman S....Gu H.F. (2008)
Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. (PubMed id 8798667)^{1, 3} Wei J....Storm D.R. (1996)
Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules. (PubMed id 12782409)^{1, 3} Celano M....Russo D. (2003)
Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets. (PubMed id 12623444)^{1, 3} Katsel P.L....Maayani S. (2003)
Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PubMed id 11549699)^{1, 3} Cote M....Gallo-Payet N. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 109	HGNC: 234	AceView: ADCY3	Ensembl:ENSG00000138031	euGenes: HUgn109
ECgene: ADCY3	H-InvDB: ADCY3

(According to HUGE)
About This Section

HUGE: KIAA0511

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADCY3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADCY3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADCY3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADCY3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADCY3		Small molecules for ADCY3
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Tocris compounds for ADCY3

	Drugs for ADCY3
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ADCY3

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ADCY3 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for ADCY3

Summaries
for ADCY3

Genomic Location
for ADCY3

Proteins
for ADCY3

Protein Domains/
Families
for ADCY3

Gene Function
for ADCY3

Pathways & Interactions
for ADCY3

Drugs & Compounds
for ADCY3

Transcripts
for ADCY3

Expression
for ADCY3

Orthologs
for ADCY3

Paralogs
for ADCY3

SNPs/Variants
for ADCY3

Disorders & Mutations
for ADCY3

Medical News
for ADCY3

Publications
for ADCY3

Search for ADCY3

Genome Databases showing ADCY3

Other Databases showing ADCY3

Specialized Databases showing ADCY3

Licensable Technologies
for ADCY3

Services
for ADCY3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADCY3 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor ADCY3

Summariesfor ADCY3

Genomic Locationfor ADCY3

Proteinsfor ADCY3

Protein Domains/Familiesfor ADCY3

Gene Functionfor ADCY3

Pathways & Interactionsfor ADCY3

Drugs & Compoundsfor ADCY3

Transcriptsfor ADCY3

Expression for ADCY3

Orthologsfor ADCY3

Paralogsfor ADCY3

SNPs/Variantsfor ADCY3

Disorders & Mutationsfor ADCY3

Medical Newsfor ADCY3

Publicationsfor ADCY3

Search for ADCY3

Genome Databases showing ADCY3

Other Databases showing ADCY3

Specialized Databases showing ADCY3

Licensable Technologiesfor ADCY3

Servicesfor ADCY3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADCY3

Summaries
for ADCY3

Genomic Location
for ADCY3

Proteins
for ADCY3

Protein Domains/
Families
for ADCY3

Gene Function
for ADCY3

Pathways & Interactions
for ADCY3

Drugs & Compounds
for ADCY3

Transcripts
for ADCY3

Expression
for ADCY3

Orthologs
for ADCY3

Paralogs
for ADCY3

SNPs/Variants
for ADCY3

Disorders & Mutations
for ADCY3

Medical News
for ADCY3

Publications
for ADCY3

Licensable Technologies
for ADCY3

Services
for ADCY3