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ADCY3 Gene

protein-coding   GIFtS: 70
GCID: GC02M025042

Adenylate Cyclase 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase 31 2     ATP Pyrophosphate-Lyase 32 3
Adenylate Cyclase Type III2 3     EC 4.6.1.13 8
Adenylate Cyclase, Olfactive Type2 3     Adenylate Cyclase Type 32
Adenylyl Cyclase 32 3     Adenylyl Cyclase, Type III2
AC-III2 3     KIAA05113
AC32 3     EC 4.6.18

External Ids:    HGNC: 2341   Entrez Gene: 1092   Ensembl: ENSG000001380317   OMIM: 6002915   UniProtKB: O602663   

Export aliases for ADCY3 gene to outside databases

Previous GC identifers: GC02M024963 GC02M025134 GC02M024999 GC02M025016 GC02M024953 GC02M024779


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCY3 Gene:
This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the
secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various
human tissues and may be involved in a number of physiological and pathophysiological metabolic processes.
(provided by RefSeq, Jul 2008)

GeneCards Summary for ADCY3 Gene:
ADCY3 (adenylate cyclase 3) is a protein-coding gene. Diseases associated with ADCY3 include precocious puberty, and thyroid adenoma. GO annotations related to this gene include adenylate cyclase activity and calmodulin binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266
Function: Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration

summary for ADCY3 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCY3 gene promoter:
         Oct-B1   oct-B3   oct-B2   POU2F2   POU2F2C   Ik-2   POU2F1   FOXO4   POU2F1a   POU2F2B   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCY3 promoter sequence
   Search Chromatin IP Primers for ADCY3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCY3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

ADCY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY3 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M025042:  view genomic region     (about GC identifiers)

Start:
25,042,038 bp from pter      End:
25,142,708 bp from pter
Size:
100,671 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266 (See protein sequence)
Recommended Name: Adenylate cyclase type 3  
Size: 1144 amino acids; 128960 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Secondary accessions: Q53T54 Q9UDB1

Explore the universe of human proteins at neXtProt for ADCY3: NX_O60266

Explore proteomics data for ADCY3 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys1046, Lys1111, Lys1120
  • Glycosylation2 at Asn736
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADCY3 (O60266) (see all 7)
     TVNVASR  WQYDVWS  ASRMEST  ADIVGFT 


    See ADCY3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004027.2  
    ENSEMBL proteins: 
     ENSP00000260600   ENSP00000475652   ENSP00000476143   ENSP00000402008   ENSP00000399275  
     ENSP00000389799   ENSP00000401455   ENSP00000406153   ENSP00000384484  
    Reactome Protein details: O60266

    ADCY3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ADCY3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADCY3
    GenScript Custom Purified and Recombinant Proteins Services for ADCY3
    Novus Biologicals ADCY3 Protein
    Novus Biologicals ADCY3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY3

    ADCY3 Antibody Products:

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    Abcam antibodies for ADCY3
    Cloud-Clone Corp. Antibodies for ADCY3
    ThermoFisher Antibodies for ADCY3
    Search LSBio for Antibodies for ADCY3

    ADCY3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ADCY3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADCY3
    Cloud-Clone Corp. CLIAs for ADCY3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC3
    Adenylyl cyclases

    2 InterPro protein domains:
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry O60266

    ProtoNet protein and cluster: O60266

    UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY3_HUMAN, O60266
    Function: Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Activated by calcium/calmodulin

         Genatlas biochemistry entry for ADCY3:
    adenylyl cyclase,type III,calmodulin sensitive,olfactory sensory neurons,brain,spinal and
    retina,heart,kidney,liver,lung,pancreas,placenta,skeletal muscle

         Enzyme Numbers (IUBMB): EC 4.6.1.11 2 EC 4.6.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity IEA--
    GO:0005515protein binding ----
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
         
    ADCY3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADCY3:
     Upregulation of Wnt/beta-caten 

         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Adcy3):
     growth/size/body  mortality/aging  nervous system  normal  reproductive system 
     taste/olfaction 

    ADCY3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Adcy3tm1Drs for ADCY3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADCY3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADCY3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY3

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADCY3:
    hsa-mir-1296-5p (MIRT036106), hsa-mir-1301-3p (MIRT035974), hsa-mir-877-5p (MIRT037340), hsa-mir-124-3p (MIRT022973)

    Block miRNA regulation of human, mouse, rat ADCY3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADCY3 (see all 26):
    hsa-miR-498 hsa-miR-3607-3p hsa-miR-25 hsa-miR-128 hsa-miR-132 hsa-miR-4325 hsa-miR-1183 hsa-miR-212
    SwitchGear 3'UTR luciferase reporter plasmidADCY3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADCY3
    Predesigned siRNA for gene silencing in human, mouse, rat ADCY3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADCY3

    Clone
    Products:
         
    OriGene clones in human, mouse for ADCY3 (see all 8)
    OriGene ORF clones in mouse, rat for ADCY3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY3 (NM_004036)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ADCY3
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADCY3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADCY3_HUMAN, O60266: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytosol1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA11549699
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9920776
    GO:0005929cilium IEA--
    GO:0016021integral component of membrane ----

    ADCY3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCY3 About   (see all 71)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Adenylate cyclase inhibitory pathway
    Adenylate cyclase inhibitory pathway0.53
    Inhibition of adenylate cyclase pathway0.00
    LPA4-mediated signaling events0.53
    Adenylate cyclase activating pathway0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADCY3 (see all 43)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    PACAP Signaling
    P2Y Receptor Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ADCY3 (see all 13)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    Selected BioSystems Pathways for ADCY3 (see all 7)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    TSH signaling pathway
    LPA receptor mediated events

    Selected Reactome Pathways for ADCY3 (see all 10)
        PKA activation
    CREB phosphorylation through the activation of Adenylate Cyclase
    PKA activation in glucagon signalling
    G alpha (z) signalling events
    Adenylate cyclase inhibitory pathway

    3 PharmGKB Pathways for ADCY3
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADCY3) (see all 32):
        Purine metabolism
    Rap1 signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis


    ADCY3 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADCY3: 
              Primary Cilia in human mouse rat
              Gap Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ADCY3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCY3 (O602662, 3 ENSP000002606004) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    STOML3Q8TAV43, ENSP000003689524I2D: score=2 STRING: ENSP00000368952
    CAMK2GQ135553, ENSP000003190604I2D: score=1 STRING: ENSP00000319060
    PDE11AENSP000002860634STRING: ENSP00000286063
    PDE1AENSP000003315744STRING: ENSP00000331574
    PDE1BENSP000002430524STRING: ENSP00000243052
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007189adenylate cyclase-activating G-protein coupled receptor signaling pathway TAS--

    ADCY3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADCY3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    Selected HMDB Compounds for ADCY3 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    7 Novoseek inferred chemical compound relationships for ADCY3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cyclic amp 53.7 1 1633161 (1)
    forskolin 52.8 3 9751186 (1), 7680573 (1), 7592612 (1)
    adenylate 44.3 10 18184921 (1), 7511849 (1), 18626075 (1), 19576885 (1) (see all 6)
    gtp 33.4 1 9218142 (1)
    calcium 31.5 25 7665559 (5), 1633161 (4), 8997178 (1), 8798667 (1) (see all 10)
    isoproterenol 24.4 2 11949887 (1), 7592612 (1)
    hydrogen 0 1 11756511 (1)



    ADCY3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADCY3 gene: 
    NM_004036.3  

    Unigene Cluster for ADCY3:

    Adenylate cyclase 3
    Hs.467898  [show with all ESTs]
    Unigene Representative Sequence: NM_004036
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260600(uc002rfs.4 uc010ykm.2) ENST00000606682 ENST00000498288
    ENST00000485887 ENST00000455323 ENST00000450524 ENST00000454027 ENST00000427849
    ENST00000435135 ENST00000479517 ENST00000433852 ENST00000438445 ENST00000405392(uc002rfr.4)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADCY3 (see all 26):
    hsa-miR-498 hsa-miR-3607-3p hsa-miR-25 hsa-miR-128 hsa-miR-132 hsa-miR-4325 hsa-miR-1183 hsa-miR-212
    SwitchGear 3'UTR luciferase reporter plasmidADCY3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ADCY3
    Predesigned siRNA for gene silencing in human, mouse, rat ADCY3
    Clone
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    OriGene clones in human, mouse for ADCY3 (see all 8)
    OriGene ORF clones in mouse, rat for ADCY3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY3 (NM_004036)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY3
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADCY3
      QuantiTect SYBR Green Assays in human, mouse, rat ADCY3
      QuantiFast Probe-based Assays in human, mouse, rat ADCY3

    Additional mRNA sequence: 

    AB011083.1 AF033861.1 AK027857.1 AK075424.1 AK095173.1 AK122926.1 BC020148.1 BC126235.1 
    BC144119.1 

    15 DOTS entries:

    DT.219077  DT.100819432  DT.120940672  DT.91826761  DT.100819430  DT.100042120  DT.92451457  DT.120940609 
    DT.95240075  DT.100819425  DT.101977950  DT.120940603  DT.120940625  DT.97822531  DT.95349064 

    Selected AceView cDNA sequences (see all 212):

    CB044936 AV725329 AW589498 BQ716966 AA743065 AI565545 BI767655 AW166397 
    AA464193 BQ081934 AA894421 AI431333 AA252998 AI126382 CB154258 AK095173 
    AA598528 BX505081 AA620918 BM464344 AI567467 CB852792 AI199632 AI422294 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADCY3 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15a · 15b ^
    SP1:                                                                          -                                                                                 
    SP2:                                                                                                                          -                                 
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                          -                                 

    ExUns: 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                            -                                       
    SP4:                                            -                             -         
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ADCY3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADCY3 expression in normal human tissues (normalized intensities)      ADCY3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAACAGAAA
    ADCY3 Expression
    About this image


    ADCY3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
     
     Placenta (Extraembryonic Tissues)
    ADCY3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCY3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.467898

    UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266
    Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADCY3: 
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADCY3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy31 , 5 adenylate cyclase 31, 5 89.99(n)1
    94.75(a)1
      12 (1.99 cM)5
    1041111  NM_138305.31  NP_612178.21 
     41331035 
    chicken
    (Gallus gallus)
    Aves ADCY31 adenylate cyclase 3 79.14(n)
    80.44(a)
      422013  XM_003641056.2  XP_003641104.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY36
    adenylate cyclase 3
    68(a)
    1 ↔ 1
    GL343333.1(654073-696497)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dnajc271 DnaJ (Hsp40) homolog, subfamily C, member 27 75.25(n)
    80.81(a)
      100038110  NM_001102684.1  NP_001096154.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adcy3l1 adenylate cyclase 3-like 73.85(n)
    77.34(a)
      571825  NM_001162542.1  NP_001156014.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ac78C3
    Ac31
    adenylate cyclase3
    Ac31
    38(a)
    (best of 2)3
    51.2(n)1
    43.95(a)1
      354191  NM_136272.31  NP_610116.21 


    ENSEMBL Gene Tree for ADCY3 (if available)
    TreeFam Gene Tree for ADCY3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADCY3 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  
    10 SIMAP similar genes for ADCY3 using alignment to 10 protein entries:     ADCY3_HUMAN (see all proteins):
    ADCY6    ADCY4    ADCY5    ADCY1    ADCY8    ADCY7
    ADCY2    NPR1    DKFZp686J099    GUCY1A3

    ADCY3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADCY3 (see all 2286)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105979431,2
    C,F--24821948(+) aaaaa-/A/A   
       A
    /AAA
    GATAA
    1 -- int12NA 4
    rs621406121,2
    F--24882009(+) TCCCTC/TGGGGA 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs763520731,2
    --24882073(+) ACTCTA/GTCTGA 1 -- us2k10--------
    rs1875435051,2
    --24882102(+) CCATAC/TTTCGC 1 -- us2k10--------
    rs1423676591,2
    --24882167(+) TTTAAA/GTAAAG 1 -- us2k10--------
    rs1442828821,2
    --25045755(+) AAAGCA/GTTCTC 1 -- int10--------
    rs1169972581,2
    C,F--25045761(+) TTCTCC/TCTGGT 1 -- int11Minor allele frequency- T:0.03EA 120
    rs22890881,2
    C,F,H--25045864(+) ATCCTT/CATCCT 1 -- int15Minor allele frequency- C:0.02EA NS 1916
    rs3706675041,2
    C--25045891(+) TTTCCC/TGGCTC 1 -- int10--------
    rs11275681,2
    C,F,O,A,H--25046090(-) ATCTCA/GGATTT 2 S syn1 ese340Minor allele frequency- N:0.00EA NA NS WA CSA EU 10796

    HapMap Linkage Disequilibrium report for ADCY3 (25042038 - 25142708 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ADCY3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv989967CNV Deletion20482838
    esv2666034CNV Deletion23128226
    esv2668898CNV Deletion23128226
    esv2678377CNV Deletion23128226
    esv2673418CNV Deletion23128226
    nsv2646CNV Insertion18451855
    nsv508831CNV Insertion20534489
    nsv873742CNV Loss21882294
    nsv524979CNV Loss19592680
    nsv2645CNV Loss18451855

    Human Gene Mutation Database (HGMD): ADCY3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADCY3
    DNA2.0 Custom Variant and Variant Library Synthesis for ADCY3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600291    OMIM disorders: --

    Selected diseases for ADCY3 (see all 22):    About MalaCards
    precocious puberty    thyroid adenoma    adenoma    chondrodysplasia
    diphtheria    thyroiditis    alcohol dependence    cholera
    dilated cardiomyopathy    major depressive disorder    labyrinthitis    type 1 diabetes
    neuronitis    obesity    inflammatory bowel disease    tuberculosis
    colorectal cancer    pancreatitis    hiv-1    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ADCY3:
    Cholera

    ADCY3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADCY3
    Human Genome Epidemiology (HuGE) Navigator: ADCY3 (10 documents)

    Export disorders for ADCY3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADCY3 gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with ADCY3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets. (PubMed id 9920776)1, 2, 3, 9 Yang B.... Hillert J. (Biochem. Biophys. Res. Commun. 1999)
    2. Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. (PubMed id 17895882)1, 4, 9 Nordman S....Gu H.F. (Int J Obes (Lond) 2008)
    3. Meta-analysis identifies common variants associated with body mass index in east Asians. (PubMed id 22344219)1, 4 Wen W....Shu X.O. (Nat. Genet. 2012)
    4. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. (PubMed id 20935630)1, 4 Speliotes E.K....Loos R.J. (Nat. Genet. 2010)
    5. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    6. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2 Nagase T....Ohara O. (DNA Res. 1998)
    9. A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line. (PubMed id 8476432)1, 2 Hellevuo K....Tabakoff B. (Biochem. Biophys. Res. Commun. 1993)
    10. Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. (PubMed id 8798667)1, 9 Wei J....Storm D.R. (J. Biol. Chem. 1996)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 109 HGNC: 234 AceView: ADCY3 Ensembl:ENSG00000138031 euGenes: HUgn109
    ECgene: ADCY3 Kegg: 109 H-InvDB: ADCY3

    (According to HUGE)
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    HUGE: KIAA0511

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADCY3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADCY3 gene:
    Search GeneIP for patents involving ADCY3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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