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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ADCY3 Gene

protein-coding GIFtS: 67
GCID: GC02M025042

adenylate cyclase 3

Explore 17 diseases affiliated with
ADCY3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Adenylate Cyclase 3¹ ²		ATP Pyrophosphate-Lyase 3² ³
AC3¹ ² ³		EC 4.6.1.1³ ⁸
Adenylate Cyclase Type III² ³		Adenylate Cyclase Type 3²
Adenylate Cyclase, Olfactive Type² ³		Adenylyl Cyclase, Type III²
Adenylyl Cyclase 3² ³		KIAA0511³
AC-III² ³		EC 4.6.1⁸

External Ids:	HGNC: 234¹	Entrez Gene: 109²	Ensembl: ENSG00000138031⁷	OMIM: 600291⁵	UniProtKB: O60266³

Export aliases for ADCY3 gene to outside databases

Previous GC identifers: GC02M024963 GC02M025134 GC02M024999 GC02M025016 GC02M024953 GC02M024779

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCY3:

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary

messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues

and may be involved in a number of physiological and pathophysiological metabolic processes. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266

Function: Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration

summary for ADCY3:

Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into

3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;

nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and

muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase

isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8

are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are

distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive

and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,

phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this

enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid

addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and

chondrodysplasia.

Gene Wiki entry for ADCY3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ADCY3 gene promoter:
Oct-B1 oct-B3 oct-B2 POU2F2 POU2F2C Ik-2 POU2F1 FOXO4 POU2F1a POU2F2B
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADCY3 promoter sequence

Search SABiosciences Chromatin IP Primers for ADCY3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3

ADCY3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY3 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M025042: view genomic region (about GC identifiers)

Start:	25,042,038 bp from pter	End:	25,142,708 bp from pter
Size:	100,671 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266 (See protein sequence)

Recommended Name: Adenylate cyclase type 3

Size: 1144 amino acids; 128960 Da

Cofactor: Binds 2 magnesium ions per subunit (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q53T54 Q9UDB1

Explore the universe of human proteins at neXtProt for ADCY3: NX_O60266

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O60266

4/7 DME Specific Peptides for ADCY3 (O60266) (see all 7)

TVNVASR

WQYDVWS

ASRMEST

ADIVGFT

ADCY3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004027.2

ENSEMBL proteins:

ENSP00000260600 ENSP00000384484 ENSP00000402008 ENSP00000410972 ENSP00000410120

ENSP00000399275 ENSP00000389799 ENSP00000401455 ENSP00000406153

Reactome Protein details: O60266
Human Recombinant Protein Products for ADCY3:

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	Novus Biologicals ADCY3 Protein Novus Biologicals ADCY3 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADCY3

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005624	membrane fraction	--	--
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	IDA	11549699
GO:0005886	plasma membrane	TAS	--

ADCY3 for ontologies About GeneDecksing

ADCY3 Antibody Products:

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	ThermoFisher Antibodies for ADCY3

Assay Products for ADCY3:

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	GenScript Custom Assay Services for ADCY3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADCY3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ADCY3 for domains About GeneDecksing

2 InterPro domains/families:

IPR001054 A/G_cyclase

IPR018297 A/G_cyclase_CS

Graphical View of Domain Structure for InterPro Entry O60266

ProtoNet protein and cluster: O60266

UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266

Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family

Similarity: Contains 2 guanylate cyclase domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ADCY3_HUMAN, O60266

Function: Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration

Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate

Enzyme regulation: Activated by calcium/calmodulin

Genatlas biochemistry entry for ADCY3:

adenylyl cyclase,type III,calmodulin sensitive,olfactory sensory neurons,brain,spinal and

retina,heart,kidney,liver,lung,pancreas,placenta,skeletal muscle

Enzyme Numbers (IUBMB): EC 4.6.1.1¹ ² EC 4.6.1²

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	--	--
GO:0004016	adenylate cyclase activity	IEA	--
GO:0005515	protein binding	--	--
GO:0005516	calmodulin binding	IEA	--
GO:0005524	ATP binding	IEA	--

ADCY3 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for ADCY3:

Upregulation of Wnt/beta-caten

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Adcy3):

growth/size	mortality/aging	nervous system	normal	reproductive system
taste/olfaction

ADCY3 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Adcy3^tm1Drs for ADCY3

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADCY3

miRNA Products:		OriGene 3'-UTR Clone: ADCY3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY3
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY3 (see all 26):
		hsa-miR-498 hsa-miR-3607-3p hsa-miR-25 hsa-miR-128 hsa-miR-132 hsa-miR-4325 hsa-miR-1183 hsa-miR-212

		SwitchGear 3'UTR luciferase reporter plasmid: ADCY3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY3 (see all 7) OriGene shRNA RFP: ADCY3 OriGene siRNA: ADCY3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY3
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADCY3

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ADCY3
			Sirion Biotech Customized adenovirus for overexpression of ADCY3 Sirion Biotech Customized adenovirus for potent knockdown of ADCY3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADCY3 (NM_004036)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADCY3
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/68 super-pathways (see all 68) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by FGFR

8/12 pathways (see all 12)
Signaling by FGFR	1.00	DAP12 signaling	0.83
Downstream signaling of activated FGFR	0.92	Signaling by EGFR in Cancer	0.83
Signaling by FGFR in disease	0.91	DAP12 interactions	0.76
Signaling by ERBB2	0.89	Signaling by PDGF	0.72

PKA activation in glucagon signalling

8/12 pathways (see all 12)
PKA activation in glucagon signalling	1.00	Neurophysiological process_PGE2-induced pain processing	0.44
PKA activation	0.94	Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling	0.37
PKA-mediated phosphorylation of CREB	0.89	Development_Role of Activin A in cell differentiation and proliferation	0.33
Regulation of CFTR gating (normal and CF)	0.76	Development Role of Activin A in cell differentiation and proliferation	0.33

DAG and IP3 signaling

DAG and IP3 signaling	1.00	CaM pathway	0.84
PLC-gamma1 signalling	0.94	Calmodulin induced events	0.84
EGFR interacts with phospholipase C-gamma	0.94	Ca-dependent events	0.79
PLCG1 events in ERBB2 signaling	0.91	Phospholipase C-mediated cascade	0.57

Regulation of Water Balance by Renal Aquaporins

Regulation of Water Balance by Renal Aquaporins	1.00	G alpha (z) signalling events	0.48
Aquaporin-mediated transport	0.84	Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation	0.40
Glucagon signaling in metabolic regulation	0.69	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation	0.40

Opioid Signalling

Opioid Signalling	1.00	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics	0.35
G-protein mediated events	0.55	Glutamatergic synapse	0.31
PLC beta mediated events	0.54

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 EMD Millipore Pathways for ADCY3 (see all 10)

	Adenylate cyclase-activating neuropeptides
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Development PDGF signaling via MAPK cascades
	Development Beta-adrenergic receptors signaling via cAMP
	Signal transduction cAMP signaling

5/43 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY3 (see all 43)

	Molecular Mechanisms of Cancer
	Intracellular Calcium Signaling
	CDK5 Pathway
	PACAP Signaling
	P2Y Receptor Signaling

5/13 GeneGo (Thomson Reuters) Pathways for ADCY3 (see all 13)

	Development Beta-adrenergic receptors signaling via cAMP
	Signal transduction cAMP signaling
	Signal transduction PKA signaling
	Development Endothelin-1/EDNRA signaling
	Regulation of CFTR activity (norm and CF)

5/7 BioSystems Pathways for ADCY3 (see all 7)

	G Protein Signaling Pathways
	Calcium Regulation in the Cardiac Cell
	Myometrial Relaxation and Contraction Pathways
	TSH signaling pathway
	Endothelins

5/53 Reactome Pathways for ADCY3 (see all 53)

	PKA activation
	Signaling by EGFR in Cancer
	Post NMDA receptor activation events
	G alpha (z) signalling events
	Downstream signal transduction

3 PharmGKB Pathways for ADCY3

	Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics
	Proton Pump Inhibitor Pathway, Pharmacodynamics

5/19 Kegg Pathways (Kegg details for ADCY3) (see all 19):

	Purine metabolism
	Calcium signaling pathway
	Chemokine signaling pathway
	Oocyte meiosis
	Vascular smooth muscle contraction

ADCY3 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ADCY3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/116 Interacting proteins for ADCY3 (O60266^{2, 3} ENSP00000260600⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 116)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
STOML3	Q8TAV4³, ENSP00000368952⁴	I2D: score=2 STRING: ENSP00000368952
CAMK2G	Q13555³, ENSP00000319060⁴	I2D: score=1 STRING: ENSP00000319060
PDE1A	ENSP00000331574⁴	STRING: ENSP00000331574
PDE1C	ENSP00000379485⁴	STRING: ENSP00000379485
PDE2A	ENSP00000334910⁴	STRING: ENSP00000334910

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006112	energy reserve metabolic process	TAS	--
GO:0006171	cAMP biosynthetic process	--	--
GO:0006833	water transport	TAS	--
GO:0007143	female meiosis	--	--
GO:0007165	signal transduction	TAS	--

ADCY3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ADCY3 for compounds About GeneDecksing

EMD Millipore small molecules for ADCY3:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for ADCY3 available from Tocris Bioscience About this table

Compound	Action	CAS #
BPIPP	Non-competitive GC inhibitor. Also AC inhibitor	[325746-94-9]
NKH 477	Water-soluble adenylyl cyclase activator	[138605-00-2]
Forskolin	Adenylyl cyclase activator	[66575-29-9]
SQ 22536	Adenylyl cyclase inhibitor	[17318-31-9]
PACAP 1-38	Potent stimulator of adenylyl cyclase	--

10/11 HMDB Compounds for ADCY3 (see all 11) About this table

Compound	Synonyms	CAS #	PubMed Ids
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
Calcium	Ca (see all 2)	7440-70-2	--
Cyclic AMP	Cyclic AMP (see all 19)	60-92-4	--
Cyclic GMP	3',5'-cyclic GMP (see all 13)	7665-99-8	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
NAD	3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)	53-84-9	--
NADH	1,4-Dihydronicotinamide adenine dinucleotide (see all 17)	58-68-4	--
Phosphoric acid	acide phosphorique (FRENCH) (see all 20)	7664-38-2	--
Pyrophosphate	(4-)Diphosphoric acid ion (see all 10)	14000-31-8	--

7 Novoseek chemical compound relationships for ADCY3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cyclic amp	53.7	1	1633161 (1)
forskolin	52.8	3	9751186 (1), 7680573 (1), 7592612 (1)
adenylate	44.3	10	18184921 (1), 7511849 (1), 18626075 (1), 19576885 (1) (see all 6)
gtp	33.4	1	9218142 (1)
calcium	31.5	25	7665559 (5), 1633161 (4), 8997178 (1), 8798667 (1) (see all 10)
isoproterenol	24.4	2	11949887 (1), 7592612 (1)
hydrogen	0	1	11756511 (1)

Search CenterWatch for drugs/clinical trials and news about ADCY3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ADCY3 gene:

NM_004036.3

Unigene Cluster for ADCY3:

Adenylate cyclase 3

Hs.467898 [show with all ESTs]

Unigene Representative Sequence: NM_004036

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000260600(uc002rfs.4 uc010ykm.2) ENST00000405392(uc002rfr.4)

ENST00000498288 ENST00000485887 ENST00000455323 ENST00000450524 ENST00000454027

ENST00000427849 ENST00000435135 ENST00000479517 ENST00000433852 ENST00000438445

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY3
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY3 (see all 26):
		hsa-miR-498 hsa-miR-3607-3p hsa-miR-25 hsa-miR-128 hsa-miR-132 hsa-miR-4325 hsa-miR-1183 hsa-miR-212

		SwitchGear 3'UTR luciferase reporter plasmid: ADCY3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY3 (see all 7) OriGene shRNA RFP: ADCY3 OriGene siRNA: ADCY3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY3
		Sirion Biotech Custom design and validation of potent shRNA sequences against ADCY3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY3 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ADCY3 (NM_004036)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ADCY3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY3

Additional cDNA sequence:

AB011083.1 AF033861.1 AK027857.1 AK075424.1 AK095173.1 AK122926.1 BC020148.1 BC126235.1

BC144119.1

14 DOTS entries:

DT.219077 DT.100819432 DT.120940672 DT.91826761 DT.100819430 DT.100042120 DT.120940603 DT.120940609

DT.120940625 DT.92451457 DT.95240075 DT.97822531 DT.101977950 DT.95349064

24/212 AceView cDNA sequences (see all 212):

AU124073 AI422294 AV725329 AA399222 AA894421 AW589498 AB011083 CB852792

AI342153 CB154258 BQ082039 AA279346 W68610 AI696614 AA278862 AA464193

CB044936 BX505081 AI199632 BQ716966 AA620918 BI767655 BQ081934 AI083759

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY3 (see all 15) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	^
SP1:																									-
SP2:																																									-
SP3:
SP4:
SP5:																																									-

ExUns:	16a	·	16b	^	17a	·	17b	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23	^	24a	·	24b	^	25
SP1:
SP2:
SP3:															-
SP4:															-										-
SP5:

ECgene alternative splicing isoforms for ADCY3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ADCY3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAACAGAAA

About this image

ADCY3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ADCY3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCY3

SOURCE GeneReport for Unigene cluster: Hs.467898

UniProtKB/Swiss-Prot: ADCY3_HUMAN, O60266

Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including ADCY3:

Primary Cilia in human mouse rat

Gap Junctions in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ADCY3 gene from 5/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ADCY3¹	adenylate cyclase 3	79.44(n) 80.7(a)		422013 XM_003641056.1 XP_003641104.1
lizard (Anolis carolinensis)	Reptilia	ADCY3⁶	--	67(a)	1 ↔ 1	GL343333.1(654073-696497)
zebrafish (Danio rerio)	Actinopterygii	adcy3l¹	adenylate cyclase 3-like	73.85(n) 77.34(a)		571825 NM_001162542.1 NP_001156014.1
fruit fly (Drosophila melanogaster)	Insecta	Ac78C³ Ac3¹	adenylate cyclase³ Ac3¹	38(a) (best of 2)³ 51.79(n)¹ 43.85(a)¹		35419¹ NM_136272.2¹ NP_610116.2¹
worm (Caenorhabditis elegans)	Secernentea	acy-4³	--	45(a)		V(5627531-5629064) --

ENSEMBL Gene Tree for ADCY3 (if available)
TreeFam Gene Tree for ADCY3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ADCY3 gene

ADCY5² ADCY2² GUCY2D² GUCY2C² NPR1² ADCY8² GUCY2F² GUCY1A2²

ADCY7² ADCY9² GUCY1B3² ADCY6² GUCY1A3² ADCY1² ADCY4² NPR2²

11 SIMAP similar genes for ADCY3 using alignment to 10 protein entries: ADCY3_HUMAN (see all proteins):

ADCY6 ADCY4 ADCY5 ADCY1 ADCY8 ADCY7

ADCY9 ADCY2 NPR1 DKFZp686J099 GUCY1A3

ADCY3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4998721^1,2	C	--	24792761(+)	`AGGGGA/GCAGGG`	1	--	int¹		0	--	--	--	--
rs77288707^1,2	C	--	24845526(+)	`TTTTTC/TCCCTT`	1	--	int¹		1		CSA	2
rs1550114^1,2	C,F,A,H	--	25041539(+)	`CCCATA/TAACTC`	3	--	ds500¹ int¹		15		NS EA NA WA CSA	790
rs139941682^1,2		--	25041558(+)	`TCAGGC/TGCCCC`	3	--	int¹ ds500¹		0	--	--	--	--
rs79682290^1,2	F	--	25041566(+)	`CCCCCG/AGGTCT`	3	--	int¹ ds500¹		3		WA NA EA	358
rs143906869^1,2		--	25041567(+)	`CCCCGG/TGTCTT`	3	--	int¹ ds500¹		0	--	--	--	--
rs150648919^1,2		--	25041608(+)	`CTGATG/TTGCCG`	3	--	int¹ ds500¹		0	--	--	--	--
rs1550115^1,2	C,F,O,A,H	--	25041620(+)	`AACCAT/CGGGCC`	3	--	int¹ ds500¹		31		NS EA NA WA CSA	2986
rs74474448^1,2		--	25041662(+)	`GTGTGG/AGTCAC`	3	--	int¹ ds500¹		1		WA	118
rs188928663^1,2		--	25041763(+)	`GCCACA/GTTCAG`	3	--	int¹ ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADCY3 (25042038 - 25142708 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADCY3: --
Human Gene Mutation Database (HGMD): ADCY3

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCY3

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ADCY3 for disorders           About GeneDecksing

OMIM gene information: 600291    OMIM disorders: --

17 diseases for ADCY3:    About MalaCards

precocious puberty thyroid adenoma chondrodysplasia adenoma

thyroiditis alcohol dependence neuronitis diphtheria

cholera obesity alcoholism tuberculosis

immunodeficiency pancreatitis mycobacterium tuberculosis colorectal cancer

breast cancer

1 disease from the University of Copenhagen DISEASES database for ADCY3:

Cholera

Human Genome Epidemiology (HuGE) Navigator: ADCY3 (10 documents)

Export disorders for ADCY3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ADCY3 gene, integrated from 9 sources (see all 98):
(articles sorted by number of sources associating them with ADCY3)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning of a full-length cDNA for human type 3 adenylyl cyclase and its expression in human islets. (PubMed id 9920776)^{1, 2, 3, 9} Yang B.... Hillert J. (1999)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)^{1, 2} Nagase T....Ohara O. (1998)
A novel adenylyl cyclase sequence cloned from the human erythroleukemia cell line. (PubMed id 8476432)^{1, 2} Hellevuo K....Tabakoff B. (1993)
Genetic variation of the adenylyl cyclase 3 (AC3) locus and its influence on type 2 diabetes and obesity susceptibility in Swedish men. (PubMed id 17895882)^{1, 9} Nordman S....Gu H.F. (2008)
Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. (PubMed id 8798667)^{1, 9} Wei J....Storm D.R. (1996)
Expression of adenylyl cyclase types III and VI in human hyperfunctioning thyroid nodules. (PubMed id 12782409)^{1, 9} Celano M....Russo D. (2003)
Molecular and biochemical evidence for the presence of type III adenylyl cyclase in human platelets. (PubMed id 12623444)^{1, 9} Katsel P.L....Maayani S. (2003)
Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PubMed id 11549699)^{1, 9} Cote M....Gallo-Payet N. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 109	HGNC: 234	AceView: ADCY3	Ensembl:ENSG00000138031	euGenes: HUgn109
ECgene: ADCY3	Kegg: 109	H-InvDB: ADCY3

(According to HUGE)
About This Section

HUGE: KIAA0511

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ADCY3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ADCY3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ADCY3 gene:
Search GeneIP for patents involving ADCY3

GeneCards and IP:
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adenylate cyclase 3

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ADCY3 Gene

adenylate cyclase 3

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