Aliases for ADCY2 Gene
External Ids for ADCY2 Gene
Previous GeneCards Identifiers for ADCY2 Gene
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
GeneCards Summary for ADCY2 Gene
ADCY2 (Adenylate Cyclase 2 (Brain)) is a Protein Coding gene. Diseases associated with ADCY2 include cholera and corneal dystrophy, reis-bucklers type. Among its related pathways are cGMP-PKG signaling pathway and Insulin secretion. GO annotations related to this gene include protein heterodimerization activity and phosphorus-oxygen lyase activity. An important paralog of this gene is ADCY3.
UniProtKB/Swiss-Prot for ADCY2 Gene
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.