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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCY2 Gene

protein-coding   GIFtS: 69
GCID: GC05P007449

adenylate cyclase 2 (brain)
 Explore 20 diseases affiliated with
ADCY2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ADCY2    

Aliases
for ADCY2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Adenylate Cyclase 2 (Brain)1 2     ATP Pyrophosphate-Lyase 22 3
AC21 2     EC 4.6.1.13 8
HBAC21 2     3',5'-Cyclic AMP Synthetase2
KIAA10601 3     Adenylate Cyclase II2
Adenylate Cyclase Type II2 3     Adenylate Cyclase Type 22
Adenylyl Cyclase 22 3     Type II Adenylate Cyclase2

External Ids:    HGNC: 2331   Entrez Gene: 1082   Ensembl: ENSG000000782957   OMIM: 1030715   UniProtKB: Q084623   

Export aliases for ADCY2 gene to outside databases

Previous GC identifers: GC05P007810 GC05P007429


Summaries
for ADCY2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADCY2:
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the
formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to
Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462
Function: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

summary for ADCY2:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY2


Genomic Views
for ADCY2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCY2 gene promoter:
         Nkx3-1   AML1a   Tal-1   Nkx3-1 v1   POU3F2   Arnt   GATA-1   E47   Nkx3-1 v2   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADCY2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCY2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.31   HGNC cytogenetic band: 5p15.3

ADCY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P007449:  view genomic region     (about GC identifiers)

Start:
 7,396,321 bp from pter      End:
 7,830,194 bp from pter
Size:
 433,874 bases      Orientation:
 plus strand

Proteins
for ADCY2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462 (See protein sequence)
Recommended Name: Adenylate cyclase type 2  
Size: 1091 amino acids; 123603 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subunit: Interacts with RAF1
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q2NKL8 Q9UDB2 Q9UPU2

Explore the universe of human proteins at neXtProt for ADCY2: NX_Q08462

Post-translational modifications:

  • Phosphorylated by RAF11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08462

    • 4/17 DME Specific Peptides for ADCY2 (Q08462) (see all 17)
     WQYDVWS  EKIKTIG  GNVLCGV  ADIVGFT 

    ADCY2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065433.2  
    ENSEMBL proteins: 
     ENSP00000342952   ENSP00000425069   ENSP00000426196   ENSP00000444803  
    Reactome Protein details: Q08462
    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: ADCY2
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    Novus Biologicals ADCY2 Protein
    Novus Biologicals ADCY2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADCY2

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ISS--
    GO:0005624membrane fraction ----
    GO:0005737cytoplasm IDA11549699
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ISS--


    ADCY2 for ontologies           About GeneDecksing



    ADCY2 Antibody Products: 
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    ThermoFisher Antibodies for ADCY2

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    Uscn ELISAs and CLIAs for ADCY2

    Protein Domains /
    Families
    for ADCY2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADCY2 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q08462

    ProtoNet protein and cluster: Q08462

    1 Blocks protein family: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    Function
    for ADCY2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462
    Function: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex (By
    similarity). Phosphorylation by RAF1 results in its activation

         Genatlas biochemistry entry for ADCY2:
    adenylyl cyclase,type II,calmodulin insensitive,brain,lung

    Enzyme Number (IUBMB): EC 4.6.1.11 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY2
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY2 (see all 57):
    hsa-miR-582-3p hsa-miR-361-5p hsa-miR-429 hsa-miR-548k hsa-miR-128 hsa-miR-3074-3p hsa-miR-3653 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmid: ADCY2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY2 (see all 7)
    OriGene shRNA RFP: ADCY2
    Browse OriGene siRNA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ADCY2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY2 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADCY2 (NM_020546)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY2 

    Cell Line
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    Search LifeMap BioReagents cell lines for ADCY2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY2

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity NAS1427768
    GO:0005524ATP binding IEA--
    GO:0008179adenylate cyclase binding ISS--
    GO:0008294calcium- and calmodulin-responsive adenylate cyclase activity IEA--


    ADCY2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADCY2:
     Increased homologous recombina 


    Pathways & Interactions
    for ADCY2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/64 super-pathways (see all 64) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    		Signaling by FGFR1.00
    		DAP12 signaling0.83
    		Downstream signaling of activated FGFR0.92
    		Signaling by EGFR in Cancer0.83
    		Signaling by FGFR in disease0.91
    		DAP12 interactions0.76
    		Signaling by ERBB20.89
    		Signaling by PDGF0.72
    2PKA activation in glucagon signalling
    8/12 pathways (see all 12)
    		PKA activation in glucagon signalling1.00
    		Neurophysiological process_PGE2-induced pain processing0.44
    		PKA activation0.94
    		Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.37
    		PKA-mediated phosphorylation of CREB0.89
    		Development_Role of Activin A in cell differentiation and proliferation0.33
    		Regulation of CFTR gating (normal and CF)0.76
    		Development Role of Activin A in cell differentiation and proliferation0.33
    3DAG and IP3 signaling
    		DAG and IP3 signaling1.00
    		CaM pathway0.84
    		PLC-gamma1 signalling0.94
    		Calmodulin induced events0.84
    		EGFR interacts with phospholipase C-gamma0.94
    		Ca-dependent events0.79
    		PLCG1 events in ERBB2 signaling0.91
    		Phospholipase C-mediated cascade0.57
    4Regulation of Water Balance by Renal Aquaporins
    		Regulation of Water Balance by Renal Aquaporins1.00
    		G alpha (z) signalling events0.48
    		Aquaporin-mediated transport0.84
    		Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation0.40
    		Glucagon signaling in metabolic regulation0.69
    		Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5Opioid Signalling
    		Opioid Signalling1.00
    		Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.35
    		G-protein mediated events0.55
    		Glutamatergic synapse0.31
    		PLC beta mediated events0.54

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/10 EMD Millipore Pathways for ADCY2 (see all 10)
        Adenylate cyclase-activating neuropeptides
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling

    5/44 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY2 (see all 44)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    PACAP Signaling
    P2Y Receptor Signaling

    5/13 GeneGo (Thomson Reuters) Pathways for ADCY2 (see all 13)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    5/8 BioSystems Pathways for ADCY2 (see all 8) 
        Nicotine Activity on Dopaminergic Neurons
    Myometrial Relaxation and Contraction Pathways
    Calcium Regulation in the Cardiac Cell
    G Protein Signaling Pathways
    TSH signaling pathway

    5/50        Reactome Pathways for ADCY2 (see all 50)
        PKA activation
    Signaling by EGFR in Cancer
    G alpha (z) signalling events
    Downstream signal transduction
    Signal Transduction

    4 PharmGKB Pathways for ADCY2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/16         Kegg Pathways  (Kegg details for ADCY2) (see all 16):
        Purine metabolism
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Vascular smooth muscle contraction


    ADCY2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/294 Interacting proteins for ADCY2 (Q084623 ENSP000003429524) via UniProtKB, MINT, STRING, and/or I2D (see all 294)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY5O956223, ENSP000004193614I2D: score=3 STRING: ENSP00000419361
    ADCY1Q088283, ENSP000002973234I2D: score=1 STRING: ENSP00000297323
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process NAS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--


    ADCY2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADCY2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADCY2 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADCY2:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADCY2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BPIPPNon-competitive GC inhibitor. Also AC inhibitor[325746-94-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    ForskolinAdenylyl cyclase activator[66575-29-9]
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    PACAP 1-38Potent stimulator of adenylyl cyclase--

    10/11 HMDB Compounds for ADCY2 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 DrugBank Compounds for ADCY2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE-- --target--10592235
    Forskolin-- 64657-11-0target--10592235

    8 Novoseek chemical compound relationships for ADCY2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 61.6 18 8836153 (7), 10752933 (2), 9037084 (1), 18310291 (1) (see all 5)
    forskolin 49.2 3 8836153 (1), 9271339 (1), 14722077 (1)
    phorbol 46.7 1 7938004 (1)
    cyclic amp 41.1 1 7998998 (1)
    isoproterenol 34.3 1 8836153 (1)
    potassium 16.1 3 9596582 (1), 7761832 (1)
    calcium 7.1 2 9596582 (1), 10328271 (1)
    dopamine 0 1 8863843 (1)

    Search CenterWatch for drugs/clinical trials and news about ADCY2 

    Transcripts
    for ADCY2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADCY2 gene: 
    NM_020546.2  

    Unigene Cluster for ADCY2:

    Adenylate cyclase 2 (brain)
    Hs.481545  [show with all ESTs]
    Unigene Representative Sequence: CR749634
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338316(uc003jdz.1 uc011cmo.1 uc010itm.1) ENST00000484965
    ENST00000498598 ENST00000515681 ENST00000513693 ENST00000493243 ENST00000382531
    ENST00000489501 ENST00000537121

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY2
    8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY2 (see all 57):
    hsa-miR-582-3p hsa-miR-361-5p hsa-miR-429 hsa-miR-548k hsa-miR-128 hsa-miR-3074-3p hsa-miR-3653 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmid: ADCY2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY2 (see all 7)
    OriGene shRNA RFP: ADCY2
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY2
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY2 
    Primer
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    Additional cDNA sequence: 

    AB028983.1 AF070583.1 AF410885.1 AK123013.1 AK127036.1 AK294555.1 AK295531.1 AK299775.1 
    AK304041.1 AK307474.1 BC111743.1 CR749634.1 L21993.1 X74210.1 

    10 DOTS entries:

    DT.415032  DT.95370224  DT.75156460  DT.95215032  DT.100657049  DT.120823415  DT.120823417  DT.91890011 
    DT.305203  DT.91690461 

    24/94 AceView cDNA sequences (see all 94):

    BQ721167 R38789 AU149572 CB155543 BQ446886 BK000372 NM_020546 AI160340 
    AU119404 T28852 AF070583 BX460055 T08790 BF961685 AA782017 AI056439 
    AK127036 AA913243 BQ182695 BX500111 BX505595 AU124797 X74210 AW089615 

    GeneLoc Exon Structure


    Expression
    for ADCY2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCAGCAGCAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADCY2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Matrigel embedded cells (Derivation of cardio...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ADCY2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCY2

    SOURCE GeneReport for Unigene cluster: Hs.481545

    UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462
    Tissue specificity: Expressed in brain

        SABiosciences Expression via Pathway-Focused PCR Array including ADCY2: 
              Gap Junctions in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for ADCY2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADCY2 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Adcy21 , 5 adenylate cyclase 21, 5 88.42(n)1
    95.6(a)1    		   13 (35.55 cM)5
    2100441  NM_153534.21  NP_705762.21 
     686200435 
    chicken
    (Gallus gallus)    		 Aves ADCY21 adenylate cyclase 2 (brain) 80.54(n)
    89.17(a)    		   420935  XM_419020.3  XP_419020.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ADCY26
    		 --
    		 86(a)
    		 1 ↔ 1
    		 4(82567607-82713116)
    zebrafish
    (Danio rerio)    		 Actinopterygii adcy2a1 adenylate cyclase 2a 73.74(n)
    83.01(a)    		   563724  XM_687081.5  XP_692173.5 
    fruit fly
    (Drosophila melanogaster)    		 Insecta rut3
    Ac76E1    		 molting cycle (sensu Insecta) adenylate
    cyclase3
    Adenylyl cyclase 76E1    		 44(a)
    (best of 6)3
    52.31(n)1
    43.07(a)1    		   12F43
    401801  NM_079449.31  NP_524173.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea acy-43   -- 43(a)
    (best of 2)    		   V(5627531-5629064)   --


    ENSEMBL Gene Tree for ADCY2 (if available)
    TreeFam Gene Tree for ADCY2 (if available) 

    Paralogs
    for ADCY2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCY2 gene
    ADCY52  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  ADCY72  
    ADCY92  GUCY1B32  ADCY62  GUCY1A32  ADCY12  ADCY42  NPR22  ADCY32  
    9 SIMAP similar genes for ADCY2 using alignment to 5 protein entries:     ADCY2_HUMAN (see all proteins):
    ADCY4    DKFZp686J099    ADCY7    ADCY6    ADCY1    ADCY5
    ADCY3    ADCY8    NPR1

    ADCY2 for paralogs           About GeneDecksing



    Genomic Variants
    for ADCY2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7793 NCBI SNPs in ADCY2 are shown (see all 7793)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1428445431,2
    		--7394501(+) CCTCTA/GGTGTC 1 -- us2k10--------
    rs773768551,2
    		--7394547(+) CCCTCA/GTCCTT 1 -- us2k10--------
    rs21720541,2
    		C,H--7394605(+) ATCCGT/AGCCCG 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1123576701,2
    		--7394635(+) GTAACG/ACAGCT 1 -- us2k12Minor allele frequency- A:0.06CSA WA 120
    rs14284011,2
    		C,--7394707(-) CTCGAA/GTGGCC 1 -- us2k13Minor allele frequency- G:0.05NA WA 240
    rs1864089391,2
    		--7394741(+) GACAAA/GGCTGA 1 -- us2k10--------
    rs1159927801,2
    		C,F,--7394905(+) TGGGGG/CCTCTT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs610573841,2
    		C,F,--7394979(+) AATGAA/CGCCCC 1 -- us2k15Minor allele frequency- C:0.20WA NA 244
    rs1916538431,2
    		--7395109(+) CAGGCC/TCCCAA 1 -- us2k10--------
    rs1151358251,2
    		C,--7395122(+) TGACAG/AGGAGG 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for ADCY2 (7396321 - 7646321 bp, first 250kb of ADCY2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for ADCY2
         4 CNVs: 51740 99053 6378 80824
         3 Indels: 64106 60517 64107

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    Disorders / Diseases
    for ADCY2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADCY2 for disorders           About GeneDecksing

    OMIM gene information: 103071    OMIM disorders: --

    20 diseases for ADCY2:    About MalaCards
    precocious puberty    thyroid adenoma    chondrodysplasia    adenoma
    mccune albright syndrome    nephrogenic diabetes insipidus    malignant neoplasm of cerebellum    thyroiditis
    diabetes insipidus    anthrax disease    pseudohypoparathyroidism    neuronitis
    neuroendocrine tumor    cholera    pertussis    colorectal cancer
    neuroblastoma    immunodeficiency    pancreatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for ADCY2:
    Cholera
    Human Genome Epidemiology (HuGE) Navigator: ADCY2 (4 documents)

    Export disorders for ADCY2 gene to outside databases

    Publications
    for ADCY2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCY2 gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with ADCY2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. (PubMed id 1427768)1, 2, 3 Stengel D.... Hanoune J. (1992)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    4. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PubMed id 11549699)1, 9 Cote M....Gallo-Payet N. (2001)
    5. CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (PubMed id 22461431)1 Hardin M....Silverman E.K. (2012)
    6. Identification of novel germline polymorphisms governi ng capecitabine sensitivity. (PubMed id 22864933)1 O'Donnell P.H....Dolan M.E. (2012)
    7. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (2012)
    8. SPARCL1, Shp2, MSH2, E-cadherin, p53, ADCY-2 and MAPK are prognosis-related in colorectal cancer. (PubMed id 21528083)1 Yu S.J....Zheng S. (2011)
    9. Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PubMed id 21228062)1 Bogard A.S....Ostrom R.S. (2011)
    10. Sub-picomolar relaxin signalling by a pre-assembled R XFP1, AKAP79, AC2, beta-arrestin 2, PDE4D3 complex. (PubMed id 20664520)1 Halls M.L. and Cooper D.M. (2010)

    External Searches for ADCY2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    Genome Databases showing ADCY2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 108 HGNC: 233 AceView: ADCY2 Ensembl:ENSG00000078295 euGenes: HUgn108
    ECgene: ADCY2 Kegg: 108 H-InvDB: ADCY2

    Other Databases showing ADCY2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1060

    Specialized Databases showing ADCY2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCY2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADCY2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ADCY2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADCY2 gene:
    Search GeneIP for patents involving ADCY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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