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Aliases for ADCY2 Gene

Aliases for ADCY2 Gene

  • Adenylate Cyclase 2 2 3 5
  • Adenylate Cyclase 2 (Brain) 2 3
  • Adenylate Cyclase Type II 3 4
  • ATP Pyrophosphate-Lyase 2 3 4
  • Adenylyl Cyclase 2 3 4
  • EC 4.6.1.1 4 61
  • 3,5-Cyclic AMP Synthetase 3
  • Type II Adenylate Cyclase 3
  • Adenylate Cyclase Type 2 3
  • Adenylate Cyclase II 3
  • KIAA1060 4
  • HBAC2 3
  • AC2 3

External Ids for ADCY2 Gene

Previous GeneCards Identifiers for ADCY2 Gene

  • GC05P007810
  • GC05P007429
  • GC05P007449

Summaries for ADCY2 Gene

Entrez Gene Summary for ADCY2 Gene

  • This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY2 Gene

ADCY2 (Adenylate Cyclase 2) is a Protein Coding gene. Among its related pathways are Signaling in Gap Junctions and Development Endothelin-1/EDNRA signaling. GO annotations related to this gene include protein heterodimerization activity and phosphorus-oxygen lyase activity. An important paralog of this gene is ADCY4.

UniProtKB/Swiss-Prot for ADCY2 Gene

  • Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

Tocris Summary for ADCY2 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY2 Gene

Genomics for ADCY2 Gene

Regulatory Elements for ADCY2 Gene

Enhancers for ADCY2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G007393 1.3 FANTOM5 ENCODE dbSUPER 19.7 -0.5 -496 3.5 CTCF SUZ12 RBBP5 RAD21 ZNF335 GLIS2 ZFHX2 POLR2A SMC3 EGR2 ADCY2 C5orf49 LOC105374645
GH05G007421 0.7 ENCODE dbSUPER 16.5 +26.6 26630 1.9 FOXA2 TEAD4 FOXA1 ADCY2 ENSG00000249865 LINC02142 LOC105374646 GC05M007635
GH05G007802 1 FANTOM5 ENCODE 10.8 +406.9 406875 0.4 CEBPB MAX MAFG CEBPG EP300 ATF2 MAFF ZNF316 CREB1 MAFK MTRR C5orf49 ENSG00000250761 ADCY2
GH05G007419 0.8 ENCODE dbSUPER 12 +24.4 24427 2.3 FOXA2 HDAC2 CHD1 CTBP2 ATF2 ADCY2 ENSG00000249865 LINC02142 ENSG00000250761 LOC105374646 GC05M007635
GH05G007260 0.7 ENCODE 7.5 -135.0 -134977 1.0 CTCF CBX3 ZNF654 TEAD4 MAX RBBP5 REST RAD21 ZNF507 HDAC2 ENSG00000247732 ADCY2 LOC105374643 ENSG00000237611
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADCY2 on UCSC Golden Path with GeneCards custom track

Promoters for ADCY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000177831 92 1001 PHF8 MAZ CHD1 RBBP5 ZNF398 ZNF335 GLIS2 ZFHX2 HDAC2 KDM6A

Genomic Location for ADCY2 Gene

Chromosome:
5
Start:
7,396,208 bp from pter
End:
7,830,081 bp from pter
Size:
433,874 bases
Orientation:
Plus strand

Genomic View for ADCY2 Gene

Genes around ADCY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY2 Gene

Proteins for ADCY2 Gene

  • Protein details for ADCY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08462-ADCY2_HUMAN
    Recommended name:
    Adenylate cyclase type 2
    Protein Accession:
    Q08462
    Secondary Accessions:
    • B7Z2C1
    • Q2NKL8
    • Q9UDB2
    • Q9UPU2

    Protein attributes for ADCY2 Gene

    Size:
    1091 amino acids
    Molecular mass:
    123603 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with RAF1 (PubMed:15385642). Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex (By similarity).

    Alternative splice isoforms for ADCY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY2 Gene

Selected DME Specific Peptides for ADCY2 Gene

Q08462:
  • LNELFGKFD
  • SRMDSTGV
  • RIKILGDCYYC
  • ADIVGFT
  • TVNVASR
  • KIQVTEET
  • TRYLESWGAA
  • WQYDVWS
  • GNVLCGV
  • EKIKTIG
  • DVTLANHME
  • RLDFLWK
  • ATGVDINMRVG
  • QQERLLLS
  • NNFHNLYVKRH
  • FASIPDFKEFY
  • ECLRLLNEII

Post-translational modifications for ADCY2 Gene

Other Protein References for ADCY2 Gene

Domains & Families for ADCY2 Gene

Gene Families for ADCY2 Gene

Graphical View of Domain Structure for InterPro Entry

Q08462

UniProtKB/Swiss-Prot:

ADCY2_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY2: view

Function for ADCY2 Gene

Molecular function for ADCY2 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type II,calmodulin insensitive,brain,lung
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by forskolin (PubMed:15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642). Phosphorylation by PKC activates the enzyme (By similarity).
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

Enzyme Numbers (IUBMB) for ADCY2 Gene

Gene Ontology (GO) - Molecular Function for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding ISS --
GO:0004016 adenylate cyclase activity NAS 1427768
GO:0004383 guanylate cyclase activity IBA --
GO:0005524 ATP binding IEA --
GO:0008179 adenylate cyclase binding ISS --
genes like me logo Genes that share ontologies with ADCY2: view
genes like me logo Genes that share phenotypes with ADCY2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCY2

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADCY2 Gene

Localization for ADCY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY2 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY2 gene
Compartment Confidence
plasma membrane 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular ISS,IEA --
GO:0005737 cytoplasm IEA,IDA 11549699
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0008074 guanylate cyclase complex, soluble IBA --
genes like me logo Genes that share ontologies with ADCY2: view

Pathways & Interactions for ADCY2 Gene

SuperPathways for ADCY2 Gene

genes like me logo Genes that share pathways with ADCY2: view

SIGNOR curated interactions for ADCY2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006171 cAMP biosynthetic process ISS --
GO:0006182 cGMP biosynthetic process IBA --
GO:0007165 signal transduction IBA --
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway ISS --
genes like me logo Genes that share ontologies with ADCY2: view

Drugs & Compounds for ADCY2 Gene

(27) Drugs for ADCY2 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1342
Phosphoric acid Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Pyruvic acid Approved Nutra 0
cyclic amp Experimental Pharma 0

(3) Additional Compounds for ADCY2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(5) Tocris Compounds for ADCY2 Gene

Compound Action Cas Number
KH 7 Selective soluble adenylyl cyclase inhibitor 330676-02-3
NKH 477 Water-soluble adenylyl cyclase activator 138605-00-2
PACAP 1-27 Potent stimulator of adenylyl cyclase 127317-03-7
PACAP 1-38 Potent stimulator of adenylyl cyclase 137061-48-4
SQ 22536 Adenylyl cyclase inhibitor 17318-31-9

(8) ApexBio Compounds for ADCY2 Gene

Compound Action Cas Number
1,9-Dideoxyforskolin 64657-18-7
Forskolin 66575-29-9
KH 7 330676-02-3
MDL 12330A hydrochloride adenylate cyclase inhibitor 40297-09-4
N6-methyladenosine (m6A) adenylate cyclase regulator 1867-73-8
NKH 477 138605-00-2
NKY 80 299442-43-6
SQ 22536 17318-31-9
genes like me logo Genes that share compounds with ADCY2: view

Drug Products

Transcripts for ADCY2 Gene

Unigene Clusters for ADCY2 Gene

Adenylate cyclase 2 (brain):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY2 Gene

No ASD Table

Relevant External Links for ADCY2 Gene

GeneLoc Exon Structure for
ADCY2
ECgene alternative splicing isoforms for
ADCY2

Expression for ADCY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCY2 Gene

mRNA differential expression in normal tissues according to GTEx for ADCY2 Gene

This gene is overexpressed in Muscle - Skeletal (x5.3), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.4), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for ADCY2 Gene

This gene is overexpressed in Monocytes (32.6) and Frontal cortex (27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCY2 Gene



Protein tissue co-expression partners for ADCY2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADCY2 Gene:

ADCY2

SOURCE GeneReport for Unigene cluster for ADCY2 Gene:

Hs.481545

mRNA Expression by UniProt/SwissProt for ADCY2 Gene:

Q08462-ADCY2_HUMAN
Tissue specificity: Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.

Evidence on tissue expression from TISSUES for ADCY2 Gene

  • Nervous system(4.9)
genes like me logo Genes that share expression patterns with ADCY2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY2 Gene

Orthologs for ADCY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY2 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY2 35
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY2 34 35
  • 90.21 (n)
cow
(Bos Taurus)
Mammalia ADCY2 34 35
  • 89.13 (n)
oppossum
(Monodelphis domestica)
Mammalia ADCY2 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy2 34 16 35
  • 88.42 (n)
rat
(Rattus norvegicus)
Mammalia Adcy2 34
  • 88.23 (n)
chicken
(Gallus gallus)
Aves ADCY2 34 35
  • 80.51 (n)
lizard
(Anolis carolinensis)
Reptilia ADCY2 35
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adcy2a 34 35
  • 73.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 36 34 35
  • 53.83 (n)
rut 36
  • 44 (a)
ACXD 36
  • 28 (a)
ACXA 36
  • 27 (a)
ACXB 36
  • 27 (a)
ACXC 36
  • 27 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010436 34
  • 50.76 (n)
worm
(Caenorhabditis elegans)
Secernentea acy-4 36
  • 43 (a)
acy-2 36 35
  • 39 (a)
Species where no ortholog for ADCY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADCY2 Gene

ENSEMBL:
Gene Tree for ADCY2 (if available)
TreeFam:
Gene Tree for ADCY2 (if available)

Paralogs for ADCY2 Gene

Paralogs for ADCY2 Gene

(9) SIMAP similar genes for ADCY2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY2: view

Variants for ADCY2 Gene

Sequence variations from dbSNP and Humsavar for ADCY2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs386352276 Uncertain significance 7,520,818(+) AGCGT(C/G)CTCAC nc-transcript-variant, reference, synonymous-codon
rs1000001751 -- 7,503,802(+) ATTGC(A/G)TGGAC intron-variant
rs1000016388 -- 7,583,627(+) TTATC(A/G)GATAA intron-variant
rs1000017497 -- 7,759,939(+) GGTTC(C/T)TGCTA intron-variant
rs1000017523 -- 7,708,089(+) CTGTC(A/T)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY2 Gene

Variant ID Type Subtype PubMed ID
dgv1574e212 CNV loss 25503493
dgv5562n100 CNV gain 25217958
dgv5563n100 CNV loss 25217958
dgv9564n54 CNV gain 21841781
esv22556 CNV loss 19812545
esv23386 CNV loss 19812545
esv2638984 CNV insertion 19546169
esv2676111 CNV deletion 23128226
esv2729708 CNV deletion 23290073
esv2763435 CNV loss 21179565
esv3303389 CNV mobile element insertion 20981092
esv3308547 CNV mobile element insertion 20981092
esv3327214 CNV insertion 20981092
esv3362134 CNV insertion 20981092
esv3565475 CNV deletion 23714750
esv3569948 CNV loss 25503493
esv3569949 CNV loss 25503493
esv3569952 CNV loss 25503493
esv3603933 CNV loss 21293372
esv3603935 CNV loss 21293372
esv8296 CNV gain 19470904
nsv1020779 CNV gain 25217958
nsv1111292 CNV tandem duplication 24896259
nsv1125835 CNV tandem duplication 24896259
nsv1125836 CNV tandem duplication 24896259
nsv1136967 CNV deletion 24896259
nsv1145052 CNV deletion 24896259
nsv327244 CNV deletion 16902084
nsv461926 CNV gain 19166990
nsv4704 CNV insertion 18451855
nsv476643 CNV novel sequence insertion 20440878
nsv517197 CNV gain 19592680
nsv596996 CNV loss 21841781
nsv596997 CNV gain 21841781
nsv596998 CNV loss 21841781
nsv597001 CNV gain 21841781
nsv597003 CNV gain 21841781
nsv597004 CNV gain 21841781
nsv830198 CNV gain 17160897
nsv950645 CNV duplication 24416366

Variation tolerance for ADCY2 Gene

Residual Variation Intolerance Score: 4.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.97; 74.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCY2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY2 Gene

Disorders for ADCY2 Gene

Relevant External Links for ADCY2

Genetic Association Database (GAD)
ADCY2
Human Genome Epidemiology (HuGE) Navigator
ADCY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY2

No disorders were found for ADCY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCY2 Gene

Publications for ADCY2 Gene

  1. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PMID: 11549699) CA'tAc M. … Gallo-Payet N. (J. Clin. Endocrinol. Metab. 2001) 3 4 22 64
  2. Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. (PMID: 1427768) Stengel D. … Hanoune J. (Hum. Genet. 1992) 2 3 4 64
  3. Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. (PMID: 21228062) Bogard A.S. … Ostrom R.S. (J. Pharmacol. Exp. Ther. 2011) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PMID: 19156168) Need A.C. … Goldstein D.B. (Eur. J. Hum. Genet. 2009) 3 46 64

Products for ADCY2 Gene

Sources for ADCY2 Gene

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