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Aliases for ADCY2 Gene

Aliases for ADCY2 Gene

  • Adenylate Cyclase 2 (Brain) 2 3
  • Adenylate Cyclase Type II 3 4
  • ATP Pyrophosphate-Lyase 2 3 4
  • Adenylyl Cyclase 2 3 4
  • EC 4.6.1.1 4 63
  • 3,5-Cyclic AMP Synthetase 3
  • Type II Adenylate Cyclase 3
  • Adenylate Cyclase II 3
  • KIAA1060 4
  • HBAC2 3
  • AC2 3

External Ids for ADCY2 Gene

Previous GeneCards Identifiers for ADCY2 Gene

  • GC05P007810
  • GC05P007429
  • GC05P007449

Summaries for ADCY2 Gene

Entrez Gene Summary for ADCY2 Gene

  • This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADCY2 Gene

ADCY2 (Adenylate Cyclase 2 (Brain)) is a Protein Coding gene. Diseases associated with ADCY2 include metaphyseal chondrodysplasia, murk jansen type. Among its related pathways are Immune System and DAG and IP3 signaling. GO annotations related to this gene include protein heterodimerization activity and phosphorus-oxygen lyase activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot for ADCY2 Gene

  • Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

Tocris Summary for ADCY2 Gene

  • Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into 3',5'-adenosine monophosphate (cyclic AMP/cAMP) and pyrophosphate. There are ten different mammalian isoforms of adenylyl cylase; nine of which are membrane-bound.

Gene Wiki entry for ADCY2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY2 Gene

Genomics for ADCY2 Gene

Regulatory Elements for ADCY2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCY2 Gene

Chromosome:
5
Start:
7,396,208 bp from pter
End:
7,830,081 bp from pter
Size:
433,874 bases
Orientation:
Plus strand

Genomic View for ADCY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY2 Gene

Proteins for ADCY2 Gene

  • Protein details for ADCY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08462-ADCY2_HUMAN
    Recommended name:
    Adenylate cyclase type 2
    Protein Accession:
    Q08462
    Secondary Accessions:
    • B7Z2C1
    • Q2NKL8
    • Q9UDB2
    • Q9UPU2

    Protein attributes for ADCY2 Gene

    Size:
    1091 amino acids
    Molecular mass:
    123603 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).;
    Quaternary structure:
    • Interacts with RAF1 (PubMed:15385642). Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex (By similarity).

    Alternative splice isoforms for ADCY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY2 Gene

Proteomics data for ADCY2 Gene at MOPED

Post-translational modifications for ADCY2 Gene

Other Protein References for ADCY2 Gene

Antibody Products

Domains & Families for ADCY2 Gene

Gene Families for ADCY2 Gene

Protein Domains for ADCY2 Gene

Graphical View of Domain Structure for InterPro Entry

Q08462

UniProtKB/Swiss-Prot:

ADCY2_HUMAN :
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.
  • Contains 2 guanylate cyclase domains.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY2: view

Function for ADCY2 Gene

Molecular function for ADCY2 Gene

GENATLAS Biochemistry:
adenylyl cyclase,type II,calmodulin insensitive,brain,lung
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by forskolin (PubMed:15385642). Is not activated by calmodulin. Inhibited by calcium ions, already at micromolar concentration. Activated by the G protein alpha subunit GNAS. Activated by the G protein beta and gamma subunit complex (By similarity). Phosphorylation by RAF1 results in its activation (PubMed:15385642). Phosphorylation by PKC activates the enzyme (By similarity).
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity).

Enzyme Numbers (IUBMB) for ADCY2 Gene

Gene Ontology (GO) - Molecular Function for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0000287 magnesium ion binding ISS --
GO:0004016 adenylate cyclase activity NAS 1427768
GO:0005524 ATP binding IEA --
GO:0008179 adenylate cyclase binding ISS --
genes like me logo Genes that share ontologies with ADCY2: view

Phenotypes for ADCY2 Gene

genes like me logo Genes that share phenotypes with ADCY2: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ADCY2 Gene

Localization for ADCY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY2 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY2 Gene COMPARTMENTS Subcellular localization image for ADCY2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular ISS --
GO:0005737 cytoplasm IDA 11549699
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane ISS --
GO:0016020 membrane ISS --
genes like me logo Genes that share ontologies with ADCY2: view

Pathways & Interactions for ADCY2 Gene

SuperPathways for ADCY2 Gene

Superpath Contained pathways
1 DAG and IP3 signaling
2 Interleukin receptor SHC signaling
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 Activation of cAMP-Dependent PKA
genes like me logo Genes that share pathways with ADCY2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for ADCY2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
GO:0006171 cAMP biosynthetic process ISS --
GO:0006833 water transport TAS --
GO:0007165 signal transduction TAS --
genes like me logo Genes that share ontologies with ADCY2: view

Drugs & Compounds for ADCY2 Gene

(16) Drugs for ADCY2 Gene - From: HMDB, NovoSeek, DrugBank, and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Capecitabine Approved, Investigational Pharma RNA processing inhibitor and thymidylate synthase inhibitor, F-pyrimidines 1179
Adenosine triphosphate Approved Nutra 0
Pyruvic acid Approved Nutra 0
Dopamine Approved Pharma Full agonist, Agonist 2814
Isoproterenol Approved Pharma Full agonist, Agonist 15

(8) Additional Compounds for ADCY2 Gene - From: Tocris, HMDB, and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
MDL 12330A hydrochloride
40297-09-4
NKH 477
138605-00-2
PACAP 1-27
127317-03-7
PACAP 1-38
137061-48-4
genes like me logo Genes that share compounds with ADCY2: view

Transcripts for ADCY2 Gene

Unigene Clusters for ADCY2 Gene

Adenylate cyclase 2 (brain):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY2 Gene

No ASD Table

Relevant External Links for ADCY2 Gene

GeneLoc Exon Structure for
ADCY2
ECgene alternative splicing isoforms for
ADCY2

Expression for ADCY2 Gene

mRNA expression in normal human tissues for ADCY2 Gene

mRNA differential expression in normal tissues according to GTEx for ADCY2 Gene

This gene is overexpressed in Muscle - Skeletal (x5.3), Brain - Anterior cingulate cortex (BA24) (x5.0), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.4), and Brain - Amygdala (x4.1).

Protein differential expression in normal tissues from HIPED for ADCY2 Gene

This gene is overexpressed in Monocytes (32.6) and Frontal cortex (27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCY2 Gene



SOURCE GeneReport for Unigene cluster for ADCY2 Gene Hs.481545

mRNA Expression by UniProt/SwissProt for ADCY2 Gene

Q08462-ADCY2_HUMAN
Tissue specificity: Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus.
genes like me logo Genes that share expression patterns with ADCY2: view

Protein tissue co-expression partners for ADCY2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADCY2 Gene

Orthologs for ADCY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADCY2 35
  • 89.13 (n)
  • 96.03 (a)
ADCY2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY2 35
  • 90.21 (n)
  • 96.15 (a)
ADCY2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy2 35
  • 88.42 (n)
  • 95.6 (a)
Adcy2 16
Adcy2 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy2 35
  • 88.23 (n)
  • 95.81 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCY2 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCY2 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCY2 35
  • 80.51 (n)
  • 89.08 (a)
ADCY2 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCY2 36
  • 84 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adcy2a 35
  • 73.74 (n)
  • 83.01 (a)
adcy2a 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ac76E 37
  • 39 (a)
ACXA 37
  • 27 (a)
ACXB 37
  • 27 (a)
ACXC 37
  • 27 (a)
ACXD 37
  • 28 (a)
rut 37
  • 44 (a)
Ac76E 35
  • 53.83 (n)
  • 45.27 (a)
Ac76E 36
  • 31 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010436 35
  • 50.76 (n)
  • 44.55 (a)
worm
(Caenorhabditis elegans)
Secernentea acy-2 37
  • 39 (a)
acy-4 37
  • 43 (a)
acy-2 36
  • 31 (a)
OneToMany
Species with no ortholog for ADCY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADCY2 Gene

ENSEMBL:
Gene Tree for ADCY2 (if available)
TreeFam:
Gene Tree for ADCY2 (if available)

Paralogs for ADCY2 Gene

(9) SIMAP similar genes for ADCY2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADCY2: view

Variants for ADCY2 Gene

Sequence variations from dbSNP and Humsavar for ADCY2 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
VAR_048247 -
VAR_029012 -

Structural Variations from Database of Genomic Variants (DGV) for ADCY2 Gene

Variant ID Type Subtype PubMed ID
nsv880826 CNV Gain 21882294
nsv881207 CNV Gain 21882294
nsv830198 CNV Gain 17160897
esv23386 CNV Loss 19812545
nsv517197 CNV Gain 19592680
nsv461926 CNV Gain 19166990
esv272820 CNV Insertion 20981092
esv267668 CNV Insertion 20981092
esv2729708 CNV Deletion 23290073
esv2676111 CNV Deletion 23128226
esv22556 CNV Loss 19812545
esv8296 CNV Gain 19470904
nsv4704 CNV Insertion 18451855
nsv327244 CNV Loss 16902084
esv2638984 CNV Insertion 19546169

Variation tolerance for ADCY2 Gene

Residual Variation Intolerance Score: 4.14% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.97; 74.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCY2 Gene

HapMap Linkage Disequilibrium report
ADCY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY2 Gene

Disorders for ADCY2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADCY2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
metaphyseal chondrodysplasia, murk jansen type
  • jansen's metaphyseal chondrodysplasia
- elite association
Search ADCY2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADCY2

Genetic Association Database (GAD)
ADCY2
Human Genome Epidemiology (HuGE) Navigator
ADCY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY2
genes like me logo Genes that share disorders with ADCY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADCY2 Gene

Publications for ADCY2 Gene

  1. Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis. (PMID: 18310291) Duerr E.M. … Chung D.C. (Endocr. Relat. Cancer 2008) 23 67
  2. Stable expression of adenylyl cyclase 2 leads to the functional rescue of human 5-HT6 receptor in a CHODUKX cell line. (PMID: 17188522) Nawoschik S.P. … Khawaja X. (J Pharmacol Toxicol Methods 2007) 23 67
  3. Dexamethasone-induced Ras protein 1 negatively regulates protein kinase C delta: implications for adenylyl cyclase 2 signaling. (PMID: 16489124) Nguyen C.H. … Watts V.J. (Mol. Pharmacol. 2006) 23 67
  4. Role of protein kinase C-dependent A-kinase anchoring proteins in lysophosphatidic acid-induced cAMP signaling in human diploid fibroblasts. (PMID: 17081159) Rhim J.H. … Park S.C. (Aging Cell 2006) 23 67
  5. Functional analysis of the interface regions involved in interactions between the central cytoplasmic loop and the C-terminal tail of adenylyl cyclase. (PMID: 14722077) Yoo B. … Chen Y. (J. Biol. Chem. 2004) 23 67

Products for ADCY2 Gene

Sources for ADCY2 Gene

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