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ADCY2 Gene

protein-coding   GIFtS: 70
GCID: GC05P007449

Adenylate Cyclase 2 (Brain)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase 2 (Brain)1 2     AC22
Adenylate Cyclase Type II2 3     HBAC22
Adenylyl Cyclase 22 3     Adenylate Cyclase II2
ATP Pyrophosphate-Lyase 22 3     Adenylate Cyclase Type 22
EC 4.6.1.13 8     Type II Adenylate Cyclase2
3',5'-Cyclic AMP Synthetase2     KIAA10603

External Ids:    HGNC: 2331   Entrez Gene: 1082   Ensembl: ENSG000000782957   OMIM: 1030715   UniProtKB: Q084623   

Export aliases for ADCY2 gene to outside databases

Previous GC identifers: GC05P007810 GC05P007429


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCY2 Gene:
This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that
catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is
insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ADCY2 Gene:
ADCY2 (adenylate cyclase 2 (brain)) is a protein-coding gene. Diseases associated with ADCY2 include anthrax disease, and precocious puberty. GO annotations related to this gene include adenylate cyclase activity and protein heterodimerization activity. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462
Function: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase

summary for ADCY2 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCY2 gene promoter:
         Nkx3-1   AML1a   Tal-1   Nkx3-1 v1   POU3F2   Arnt   GATA-1   E47   Nkx3-1 v2   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCY2 promoter sequence
   Search Chromatin IP Primers for ADCY2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.3   Ensembl cytogenetic band:  5p15.31   HGNC cytogenetic band: 5p15.3

ADCY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P007449:  view genomic region     (about GC identifiers)

Start:
7,396,321 bp from pter      End:
7,830,194 bp from pter
Size:
433,874 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462 (See protein sequence)
Recommended Name: Adenylate cyclase type 2  
Size: 1091 amino acids; 123603 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subunit: Interacts with RAF1
Secondary accessions: Q2NKL8 Q9UDB2 Q9UPU2

Explore the universe of human proteins at neXtProt for ADCY2: NX_Q08462

Explore proteomics data for ADCY2 at MOPED

Post-translational modifications: 

  • Phosphorylated by RAF11
  • Ubiquitination2 at Lys1015
  • Glycosylation2 at Asn713, Asn716
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADCY2 (Q08462) (see all 17)
     WQYDVWS  EKIKTIG  GNVLCGV  ADIVGFT 


    See ADCY2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065433.2  
    ENSEMBL proteins: 
     ENSP00000342952   ENSP00000425069   ENSP00000426196   ENSP00000444803  
    Reactome Protein details: Q08462

    ADCY2 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ADCY2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADCY2
    GenScript Custom Purified and Recombinant Proteins Services for ADCY2
    Novus Biologicals ADCY2 Protein
    Novus Biologicals ADCY2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY2

    ADCY2 Antibody Products:

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    ADCY2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for ADCY2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADCY2
    Cloud-Clone Corp. CLIAs for ADCY2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC2
    Adenylyl cyclases

    3 InterPro protein domains:
     IPR009398 Adenylate_cyclase-like
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q08462

    ProtoNet protein and cluster: Q08462

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY2_HUMAN, Q08462
    Function: This is a membrane-bound, calmodulin-insensitive adenylyl cyclase
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Insensitive to calcium/calmodulin. Stimulated by the G protein beta and gamma subunit complex
    (By similarity). Phosphorylation by RAF1 results in its activation

         Genatlas biochemistry entry for ADCY2:
    adenylyl cyclase,type II,calmodulin insensitive,brain,lung

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity NAS1427768
    GO:0005515protein binding ----
    GO:0005524ATP binding IEA--
    GO:0008179adenylate cyclase binding ISS--
         
    ADCY2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADCY2:
     Increased homologous recombina 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADCY2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ADCY2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ADCY2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADCY2 (see all 57):
    hsa-miR-582-3p hsa-miR-361-5p hsa-miR-429 hsa-miR-548k hsa-miR-128 hsa-miR-3074-3p hsa-miR-3653 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidADCY2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADCY2
    Predesigned siRNA for gene silencing in human, mouse, rat ADCY2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADCY2

    Clone
    Products:
         
    OriGene clones in human, mouse for ADCY2 (see all 7)
    OriGene ORF clones in mouse, rat for ADCY2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY2 (NM_020546)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ADCY2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADCY2_HUMAN, Q08462: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    cytoskeleton2
    cytosol2
    endoplasmic reticulum2
    nucleus2
    golgi apparatus1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ISS--
    GO:0005737cytoplasm IDA11549699
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ISS--
    GO:0016021integral component of membrane IEA--

    ADCY2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCY2 About   (see all 67)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Adenylate cyclase inhibitory pathway
    Adenylate cyclase inhibitory pathway0.53
    Inhibition of adenylate cyclase pathway0.00
    LPA4-mediated signaling events0.53
    Adenylate cyclase activating pathway0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5ADP signalling through P2Y purinoceptor 12
    G alpha (z) signalling events0.47
    Beta-agonist/Beta-blocker Pathway, Pharmacodynamics0.34

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADCY2 (see all 44)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    PACAP Signaling
    P2Y Receptor Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ADCY2 (see all 13)
        Development Beta-adrenergic receptors signaling via cAMP
    Signal transduction cAMP signaling
    Signal transduction PKA signaling
    Development Endothelin-1/EDNRA signaling
    Regulation of CFTR activity (norm and CF)

    Selected BioSystems Pathways for ADCY2 (see all 8)
        Myometrial Relaxation and Contraction Pathways
    G Protein Signaling Pathways
    Nicotine Activity on Dopaminergic Neurons
    Calcium Regulation in the Cardiac Cell
    TSH signaling pathway

    Selected Reactome Pathways for ADCY2 (see all 9)
        PKA activation
    PKA activation in glucagon signalling
    G alpha (z) signalling events
    Adenylate cyclase inhibitory pathway
    Glucagon signaling in metabolic regulation

    4 PharmGKB Pathways for ADCY2
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADCY2) (see all 29):
        Purine metabolism
    Rap1 signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis


    ADCY2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ADCY2: 
              Gap Junctions in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADCY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCY2 (Q084623 ENSP000003429524) via UniProtKB, MINT, STRING, and/or I2D (see all 309)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY5O956223, ENSP000004193614I2D: score=3 STRING: ENSP00000419361
    ADCY1Q088283, ENSP000002973234I2D: score=1 STRING: ENSP00000297323
    GNASQ5JWF23, ENSP000003601414I2D: score=1 STRING: ENSP00000360141
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY4ENSP000003121264STRING: ENSP00000312126
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process ISS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    ADCY2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADCY2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    Selected HMDB Compounds for ADCY2 (see all 11)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 DrugBank Compounds for ADCY2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE-- --target--10592235
    Forskolin-- 64657-11-0target--10592235

    8 Novoseek inferred chemical compound relationships for ADCY2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenylate 61.6 18 8836153 (7), 10752933 (2), 9037084 (1), 18310291 (1) (see all 5)
    forskolin 49.2 3 8836153 (1), 9271339 (1), 14722077 (1)
    phorbol 46.7 1 7938004 (1)
    cyclic amp 41.1 1 7998998 (1)
    isoproterenol 34.3 1 8836153 (1)
    potassium 16.1 3 9596582 (1), 7761832 (1)
    calcium 7.1 2 9596582 (1), 10328271 (1)
    dopamine 0 1 8863843 (1)



    ADCY2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADCY2 gene: 
    NM_020546.2  

    Unigene Cluster for ADCY2:

    Adenylate cyclase 2 (brain)
    Hs.481545  [show with all ESTs]
    Unigene Representative Sequence: CR749634
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338316(uc003jdz.1 uc011cmo.1 uc010itm.1) ENST00000484965
    ENST00000498598 ENST00000515681 ENST00000513693 ENST00000493243 ENST00000382531
    ENST00000489501 ENST00000537121
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADCY2 (see all 57):
    hsa-miR-582-3p hsa-miR-361-5p hsa-miR-429 hsa-miR-548k hsa-miR-128 hsa-miR-3074-3p hsa-miR-3653 hsa-miR-301a
    SwitchGear 3'UTR luciferase reporter plasmidADCY2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ADCY2
    Predesigned siRNA for gene silencing in human, mouse, rat ADCY2
    Clone
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    OriGene clones in human, mouse for ADCY2 (see all 7)
    OriGene ORF clones in mouse, rat for ADCY2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY2 (NM_020546)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADCY2
      QuantiTect SYBR Green Assays in human, mouse, rat ADCY2
      QuantiFast Probe-based Assays in human, mouse, rat ADCY2

    Additional mRNA sequence: 

    AB028983.1 AF070583.1 AF410885.1 AK123013.1 AK127036.1 AK294555.1 AK295531.1 AK299775.1 
    AK304041.1 AK307474.1 BC111743.1 CR749634.1 L21993.1 X74210.1 

    10 DOTS entries:

    DT.415032  DT.95370224  DT.75156460  DT.95215032  DT.100657049  DT.120823415  DT.120823417  DT.91890011 
    DT.305203  DT.91690461 

    Selected AceView cDNA sequences (see all 94):

    AU149572 T28852 CB155543 BK000372 NM_020546 BQ182695 BQ446886 T08790 
    AA782017 BQ721167 AU119404 R38789 AI056439 AI160340 AF070583 BF961685 
    AA913243 AK127036 BX460055 CR749634 AW390690 BM543474 AU148589 AW089615 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADCY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAGCAGCAC
    ADCY2 Expression
    About this image


    ADCY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Membranous Facial Bones
     
     Kidney (Urinary System)
             Metanephros
     
     Lower Urinary Tract (Urinary System)
             Ureter
    ADCY2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCY2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.481545

    UniProtKB/Swiss-Prot: ADCY2_HUMAN, Q08462
    Tissue specificity: Expressed in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including ADCY2: 
              Gap Junctions in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADCY2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy21 , 5 adenylate cyclase 21, 5 88.42(n)1
    95.6(a)1
      13 (35.55 cM)5
    2100441  NM_153534.21  NP_705762.21 
     686200435 
    chicken
    (Gallus gallus)
    Aves ADCY21 adenylate cyclase 2 (brain) 80.51(n)
    89.08(a)
      420935  XM_419020.4  XP_419020.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY26
    adenylate cyclase 2 (brain)
    84(a)
    1 ↔ 1
    4(82566999-82713101)
    zebrafish
    (Danio rerio)
    Actinopterygii adcy2a1 adenylate cyclase 2a 73.74(n)
    83.01(a)
      563724  XM_687081.6  XP_692173.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta rut3
    Ac76E1
    molting cycle (sensu Insecta) adenylate
    cyclase3
    Adenylyl cyclase 76E1
    44(a)
    (best of 6)3
    53.83(n)1
    45.27(a)1
      12F43
    401801  NM_079449.41  NP_524173.21 
    worm
    (Caenorhabditis elegans)
    Secernentea acy-43   -- 43(a)
    (best of 2)
      V(5627531-5629064)   --


    ENSEMBL Gene Tree for ADCY2 (if available)
    TreeFam Gene Tree for ADCY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADCY2 gene
    ADCY52  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  ADCY72  
    ADCY92  GUCY1B32  ADCY62  ADCY12  GUCY1A32  ADCY42  NPR22  ADCY32  
    9 SIMAP similar genes for ADCY2 using alignment to 5 protein entries:     ADCY2_HUMAN (see all proteins):
    ADCY4    DKFZp686J099    ADCY7    ADCY6    ADCY1    ADCY5
    ADCY8    ADCY3    NPR1

    ADCY2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADCY2 (see all 9109)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1428445431,2
    C--7394501(+) CCTCTA/GGTGTC 1 -- us2k10--------
    rs773768551,2
    C--7394547(+) CCCTCA/GTCCTT 1 -- us2k10--------
    rs21720541,2
    C,H--7394605(+) ATCCGT/AGCCCG 1 -- us2k14Minor allele frequency- A:0.00NS EA 418
    rs1123576701,2
    C,F--7394635(+) GTAACG/ACAGCT 1 -- us2k12Minor allele frequency- A:0.06CSA WA 120
    rs14284011,2
    C--7394707(-) CTCGAA/GTGGCC 1 -- us2k13Minor allele frequency- G:0.05NA WA 240
    rs1864089391,2
    --7394741(+) GACAAA/GGCTGA 1 -- us2k10--------
    rs1159927801,2
    C,F--7394905(+) TGGGGG/CCTCTT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs610573841,2
    C,F--7394979(+) AATGAA/CGCCCC 1 -- us2k15Minor allele frequency- C:0.20WA NA 244
    rs1916538431,2
    --7395109(+) CAGGCC/TCCCAA 1 -- us2k10--------
    rs1151358251,2
    C--7395122(+) TGACAG/AGGAGG 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for ADCY2 (7396321 - 7646321 bp, first 250kb of ADCY2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADCY2 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729708CNV Deletion23290073
    esv2676111CNV Deletion23128226
    esv267668CNV Insertion20981092
    esv272820CNV Insertion20981092
    esv2638984CNV Insertion19546169
    nsv4704CNV Insertion18451855
    nsv327244CNV Loss16902084
    esv23386CNV Loss19812545
    esv22556CNV Loss19812545
    esv8296CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ADCY2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103071    OMIM disorders: --

    Selected diseases for ADCY2 (see all 25):    
    About MalaCards
    anthrax disease    precocious puberty    thyroid adenoma    adenoma
    chondrodysplasia    pseudohypoparathyroidism    mccune albright syndrome    substance dependence
    nephrogenic diabetes insipidus    diabetes insipidus    thyroiditis    neuroendocrine tumor
    dilated cardiomyopathy    pertussis    cholera    asthma
    hypertension    neuroblastoma    neuronitis    colorectal cancer

    9 diseases from the University of Copenhagen DISEASES database for ADCY2:
    Cholera     Pseudohypoparathyroidism     Pertussis     McCune Albright syndrome
    Neuroblastoma     Heart disease     Hypertension     Nephrogenic diabetes insipidus
    Substance dependence

    ADCY2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADCY2
    Human Genome Epidemiology (HuGE) Navigator: ADCY2 (4 documents)

    Export disorders for ADCY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADCY2 gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with ADCY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Different chromosomal localization of two adenylyl cyclase genes expressed in human brain. (PubMed id 1427768)1, 2, 3 Stengel D.... Hanoune J. (Hum. Genet. 1992)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    4. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1, 4 Uhl G.R....Lerman C. (Arch. Gen. Psychiatry 2008)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R.... Ohara O. (DNA Res. 1999)
    7. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. (PubMed id 11549699)1, 9 CA'tAc M....Gallo-Payet N. (J. Clin. Endocrinol. Metab. 2001)
    8. AKAP79, PKC, PKA and PDE4 participate in a Gq-linked muscarinic receptor and adenylate cyclase 2 cAMP signalling complex. (PubMed id 23889134)1 Shen J.X. and Cooper D.M. (Biochem. J. 2013)
    9. Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling. (PubMed id 23504261)1 Conley J.M. and Watts V.J. (Cell. Mol. Neurobiol. 2013)
    10. CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. (PubMed id 22461431)1 Hardin M....Silverman E.K. (Am. J. Respir. Cell Mol. Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 108 HGNC: 233 AceView: ADCY2 Ensembl:ENSG00000078295 euGenes: HUgn108
    ECgene: ADCY2 Kegg: 108 H-InvDB: ADCY2

    (According to HUGE)
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    HUGE: KIAA1060

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADCY2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ADCY2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADCY2 gene:
    Search GeneIP for patents involving ADCY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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