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Aliases for ADCY10 Gene

Aliases for ADCY10 Gene

  • Adenylate Cyclase 10 (Soluble) 2 3
  • SAC 3 4 6
  • Germ Cell Soluble Adenylyl Cyclase 3 4
  • AH-Related Protein 3 4
  • EC 4.6.1.1 4 64
  • HCA2 3 6
  • HsAC 3 4
  • Testicular Soluble Adenylyl Cyclase (SAC) 3
  • Testicular Soluble Adenylyl Cyclase 4
  • 3,5-Cyclic AMP Synthetase 3
  • Adenylate Cyclase Type 10 3
  • Adenylate Cyclase Homolog 4
  • Soluble Adenylyl Cyclase 2
  • ATP Pyrophosphate-Lyase 3
  • Hypercalciuria 2
  • Absorptive 2
  • SACI 3
  • Sacy 3
  • 2 2

External Ids for ADCY10 Gene

Summaries for ADCY10 Gene

Entrez Gene Summary for ADCY10 Gene

  • The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

GeneCards Summary for ADCY10 Gene

ADCY10 (Adenylate Cyclase 10 (Soluble)) is a Protein Coding gene. Diseases associated with ADCY10 include idiopathic hypercalciuria and cholera. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include magnesium ion binding and ATPase binding.

UniProtKB/Swiss-Prot for ADCY10 Gene

  • Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.

Gene Wiki entry for ADCY10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY10 Gene

Genomics for ADCY10 Gene

Genomic Location for ADCY10 Gene

Start:
167,809,120 bp from pter
End:
167,914,369 bp from pter
Size:
105,250 bases
Orientation:
Minus strand

Genomic View for ADCY10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY10 Gene

Regulatory Elements for ADCY10 Gene

Proteins for ADCY10 Gene

  • Protein details for ADCY10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PN6-ADCYA_HUMAN
    Recommended name:
    Adenylate cyclase type 10
    Protein Accession:
    Q96PN6
    Secondary Accessions:
    • B4DZF0
    • F5GWS5
    • O95558
    • Q5R329
    • Q5R330
    • Q8WXV4
    • Q9NNX0

    Protein attributes for ADCY10 Gene

    Size:
    1610 amino acids
    Molecular mass:
    187149 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Note=Binds 2 magnesium ions per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADCY10 Gene

    Alternative splice isoforms for ADCY10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY10 Gene

Proteomics data for ADCY10 Gene at MOPED

Post-translational modifications for ADCY10 Gene

Other Protein References for ADCY10 Gene

Domains for ADCY10 Gene

Gene Families for ADCY10 Gene

HGNC:
  • ADCY :Adenylate cyclases

UniProtKB/Swiss-Prot:

ADCYA_HUMAN
Domain:
  • Contains 2 guanylate cyclase domains.:
    • Q96PN6
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.:
    • Q96PN6
genes like me logo Genes that share domains with ADCY10: view

Function for ADCY10 Gene

Molecular function for ADCY10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.8 mM for ATP-Mn(2+) {ECO:0000269 PubMed:12609998}; KM=2.41 mM for Mg(2+) {ECO:0000269 PubMed:12609998};
UniProtKB/Swiss-Prot CatalyticActivity: ATP = 3,5-cyclic AMP + diphosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activated by bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium.
UniProtKB/Swiss-Prot Function: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.

Enzyme Numbers (IUBMB) for ADCY10 Gene

Gene Ontology (GO) - Molecular Function for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004016 adenylate cyclase activity NAS 9874775
GO:0005524 ATP binding IEA --
GO:0016849 phosphorus-oxygen lyase activity --
GO:0030145 manganese ion binding IEA --
genes like me logo Genes that share ontologies with ADCY10: view

Phenotypes for ADCY10 Gene

genes like me logo Genes that share phenotypes with ADCY10: view

Animal Models for ADCY10 Gene

MGI Knock Outs for ADCY10:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ADCY10 Gene

Localization for ADCY10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY10 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY10 Gene COMPARTMENTS Subcellular localization image for ADCY10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 5
endoplasmic reticulum 1
extracellular 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9874775
GO:0005829 cytosol NAS 9874775
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with ADCY10: view

Pathways for ADCY10 Gene

genes like me logo Genes that share pathways with ADCY10: view

Pathways by source for ADCY10 Gene

Gene Ontology (GO) - Biological Process for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006171 cAMP biosynthetic process NAS 9874775
GO:0007283 spermatogenesis IEA --
GO:0009190 cyclic nucleotide biosynthetic process --
GO:0035556 intracellular signal transduction IEA --
GO:0043065 positive regulation of apoptotic process IEA --
genes like me logo Genes that share ontologies with ADCY10: view

Compounds for ADCY10 Gene

(6) HMDB Compounds for ADCY10 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Calcium
  • Ca
7440-70-2
Cyclic AMP
  • Cyclic AMP
60-92-4
Hydrogen carbonate
  • Bicarbonate
71-52-3
Magnesium
  • Magnesium
7439-95-4

(128) Novoseek inferred chemical compound relationships for ADCY10 Gene

Compound -log(P) Hits PubMed IDs
adenylate 98.7 550
forskolin 93.4 127
cyclic amp 91.1 133
sq 22536 82.1 28
ibmx 81.2 33
genes like me logo Genes that share compounds with ADCY10: view

Transcripts for ADCY10 Gene

Unigene Clusters for ADCY10 Gene

Adenylate cyclase 10 (soluble):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -
SP6: -
SP7:
SP8: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for ADCY10 Gene

GeneLoc Exon Structure for
ADCY10
ECgene alternative splicing isoforms for
ADCY10

Expression for ADCY10 Gene

mRNA expression in normal human tissues for ADCY10 Gene

mRNA differential expression in normal tissues according to GTEx for ADCY10 Gene

This gene is overexpressed in Testis (23.6) and Liver (9.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCY10 Gene

SOURCE GeneReport for Unigene cluster for ADCY10 Gene Hs.320892

mRNA Expression by UniProt/SwissProt for ADCY10 Gene

Q96PN6-ADCYA_HUMAN
Tissue specificity: Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.
genes like me logo Genes that share expressions with ADCY10: view

Orthologs for ADCY10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY10 36
  • 99.25 (n)
  • 98.76 (a)
ADCY10 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCY10 36
  • 85.65 (n)
  • 79.88 (a)
ADCY10 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY10 36
  • 86.13 (n)
  • 80.5 (a)
ADCY10 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy10 36
  • 81.77 (n)
  • 77.67 (a)
Adcy10 16
Adcy10 37
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCY10 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
-- 37
  • 67 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Adcy10 36
  • 81.35 (n)
  • 77.6 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 31 (a)
OneToMany
-- 37
  • 34 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 32 (a)
OneToMany
LOC101751665 36
  • 63.25 (n)
  • 47.44 (a)
lizard
(Anolis carolinensis)
Reptilia ADCY10 37
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008683 36
  • 47.79 (n)
  • 33.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 37 (a)
OneToOne
Species with no ortholog for ADCY10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADCY10 Gene

ENSEMBL:
Gene Tree for ADCY10 (if available)
TreeFam:
Gene Tree for ADCY10 (if available)

Paralogs for ADCY10 Gene

Pseudogenes.org Pseudogenes for ADCY10 Gene

genes like me logo Genes that share paralogs with ADCY10: view

No data available for Paralogs for ADCY10 Gene

Variants for ADCY10 Gene

Sequence variations from dbSNP and Humsavar for ADCY10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs129717 -- 167,869,566(+) taagc(C/T)tggta intron-variant
rs129718 -- 167,869,567(+) AAGCC(C/T)GGTAG intron-variant
rs189958 -- 167,851,350(-) aatta(C/G)ccggg intron-variant
rs203773 -- 167,898,921(+) TCAAT(C/G)TGCAA intron-variant
rs203774 -- 167,902,327(+) GAGGT(A/C)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY10 Gene

Variant ID Type Subtype PubMed ID
esv32660 CNV Loss 17666407
nsv527119 CNV Loss 19592680
nsv464239 CNV Loss 19166990
esv273284 CNV Insertion 20981092
esv267723 CNV Insertion 20981092
esv2719217 CNV Deletion 23290073

Relevant External Links for ADCY10 Gene

HapMap Linkage Disequilibrium report
ADCY10
Human Gene Mutation Database (HGMD)
ADCY10

Disorders for ADCY10 Gene

(1) OMIM Diseases for ADCY10 Gene (605205)

UniProtKB/Swiss-Prot

ADCYA_HUMAN
  • Hypercalciuria absorptive 2 (HCA2) [MIM:143870]: A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. {ECO:0000269 PubMed:11932268}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for ADCY10 Gene

(91) Novoseek inferred disease relationships for ADCY10 Gene

Disease -log(P) Hits PubMed IDs
platelet adenylate cyclase activity 76.9 1
cholera 76.7 64
pseudohypoparathyroidism 61.1 5
pseudohypoparathyroidism, type ii 57.2 1
osteosarcoma 41.7 9

Relevant External Links for ADCY10

Genetic Association Database (GAD)
ADCY10
Human Genome Epidemiology (HuGE) Navigator
ADCY10
genes like me logo Genes that share disorders with ADCY10: view

Publications for ADCY10 Gene

  1. Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. (PMID: 17591988) Schmid A. … Salathe M. (J. Gen. Physiol. 2007) 3 4 23
  2. Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate. (PMID: 12609998) Litvin T.N. … Levin L.R. (J. Biol. Chem. 2003) 3 4 23
  3. Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. (PMID: 20130594) Zippin J.H. … Magro C.M. (J. Invest. Dermatol. 2010) 3 23
  4. Bicarbonate-regulated soluble adenylyl cyclase. (PMID: 11875252) Wuttke M.S. … Levin L.R. (JOP 2001) 3 23
  5. Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation. (PMID: 19064610) Cheung C.L. … Kung A.W. (Hum. Mol. Genet. 2009) 3 49

Products for ADCY10 Gene

Sources for ADCY10 Gene

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