ADCY10 Gene
protein-coding GIFtS: 57
GCID: GC01M167778
|
|
adenylate cyclase 10 (soluble)
| |
Aliases
for ADCY10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenylate Cyclase 10 (Soluble)1 2 | | EC 4.6.1.13 8 | | SAC1 2 3 5 | | 3',5'-Cyclic AMP Synthetase2 | | HCA21 2 5 | | Adenylate Cyclase Type 102 | | RP1-313L4.21 2 | | ATP Pyrophosphate-Lyase2 | | SACI1 2 | | Testicular Soluble Adenylyl Cyclase (SAC)2 | | Sacy1 2 | | Adenylate Cyclase Homolog3 | | Germ Cell Soluble Adenylyl Cyclase2 3 | | SAC1 2 3 5 | | AH-Related Protein2 3 | | Testicular Soluble Adenylyl Cyclase3 | | HsAC1 | | |
Export aliases for ADCY10 gene to outside databasesPrevious GC identifers: GC01M166046 GC01M139024 |
Summaries
for ADCY10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADCY10:
The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble andinsensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughoutthe body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles insperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Genetic variationsin this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. (provided by RefSeq, Nov 2009)
UniProtKB/Swiss-Prot: ADCYA_HUMAN, Q96PN6Function: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP whichmediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Inducescapacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.Involved in ciliary beat regulation
Gene Wiki entry for ADCY10
|
Genomic Views
for ADCY10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADCY10 gene promoter:
Sox5 NRSF form 1 Nkx2-5 NRSF form 2 CREB AREB6 deltaCREB Sox9
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADCY10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q24 Ensembl cytogenetic band: 1q24.2 HGNC cytogenetic band: 1q24ADCY10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M167778: view genomic region
(about GC identifiers)
Start:
|
167,778,625 bp from pter |
End:
|
167,883,453 bp from pter |
Size:
|
104,829 bases |
Orientation:
|
minus strand |
|
Proteins
for ADCY10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADCYA_HUMAN, Q96PN6 (See
protein sequence)Recommended Name: Adenylate cyclase type 10 Size: 1610 amino acids; 187149 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subcellular location: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm,perinuclear region. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasmamembrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin ortubulin
Secondary accessions: B4DZF0 F5GWS5 O95558 Q5R329 Q5R330 Q8WXV4 Q9NNX0Alternative splicing: 4 isoforms: Q96PN6-1 Q96PN6-2 Q96PN6-3 Q96PN6-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ADCY10: NX_Q96PN6
Post-translational modifications:
Cleavage may occur to generate the active 48 kDa form1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PN6
4/12 DME Specific Peptides for ADCY10 (Q96PN6) (see all 12)
ADCY10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001161221.1 NP_060887.2
ENSEMBL proteins: ENSP00000356825 ENSP00000356822 ENSP00000441992
Human Recombinant Protein Products:
Gene Ontology (GO): 5/13 cellular component terms (GO ID links to tree view) (see all 13): About this table
ADCY10 for ontologies About GeneDecksing
ADCY10 Antibody Products:
Assay Products for ADCY10: |
Protein
Domains /
Families
for ADCY10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADCY10 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96PN6ProtoNet protein and cluster: Q96PN6 UniProtKB/Swiss-Prot: ADCYA_HUMAN, Q96PN6Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase familySimilarity: Contains 2 guanylate cyclase domains |
Function
for ADCY10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADCYA_HUMAN, Q96PN6Function: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP whichmediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Inducescapacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.Involved in ciliary beat regulationCatalytic activity: ATP = 3',5'-cyclic AMP + diphosphateEnzyme regulation: Activated by manganese or magnesium ions. In the presence of magnesium ions, the enzyme is activatedby bicarbonate while in the presence of manganese ions, the enzyme is inhibited by bicarbonate. In the absence ofmagnesium and bicarbonate, the enzyme is weakly activated by calciumBiophysicochemical properties: Kinetic parameters: KM=0.8 mM for ATP-Mn(2+); KM=2.41 mM for Mg(2+);Enzyme Number (IUBMB): EC 4.6.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY10 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ADCY10 (NM_018417) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCY10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY10 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ADCY10 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ADCY10:
Animal Models:
Mouse knock-out Adcy10tm1Lex for ADCY10
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Adcy10):
ADCY10 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADCY10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Purine metabolism | | | 2 | Endothelin | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for ADCY10
1 
Kegg Pathway (Kegg details for ADCY10):
ADCY10 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/75 Interacting proteins for ADCY10 (Q96PN63 ENSP000003568254) via UniProtKB, MINT, STRING, and/or I2D (see all 75)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table
ADCY10 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADCY10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADCY10 for compounds About GeneDecksing
 Browse Tocris compounds for ADCY10
6 HMDB Compounds for ADCY10 About this table
10/128 Novoseek chemical compound relationships for ADCY10 gene (see all 128) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenylate |
98.7 |
4930 |
1696150 (12), 8836153 (10), 1688553 (10), 1901530 (10) (see all 99) |
| forskolin |
93.4 |
544 |
1696150 (3), 1688553 (3), 2153911 (2), 2129432 (2) (see all 99) |
| cyclic amp |
91.1 |
343 |
8312859 (4), 2156988 (4), 16627466 (3), 9850009 (3) (see all 99) |
| sq 22536 |
82.1 |
33 |
11438697 (1), 12606604 (1), 12972400 (1), 16160094 (1) (see all 28) |
| ibmx |
81.2 |
45 |
1688553 (3), 7540897 (2), 1688464 (1), 8390534 (1) (see all 30) |
| isoproterenol |
80.7 |
121 |
8392940 (4), 2154129 (2), 8381057 (2), 2175867 (2) (see all 92) |
| 2',5'-dideoxyadenosine |
80.6 |
31 |
15684499 (4), 2167226 (1), 2174073 (1), 1321639 (1) (see all 23) |
| tmac |
76.4 |
8 |
17591988 (2), 19061075 (2), 16309816 (1), 16934836 (1) |
| dbc-amp |
74.3 |
19 |
2171930 (1), 1980742 (1), 7891085 (1), 8925408 (1) (see all 16) |
| pge1 |
74.3 |
59 |
8919301 (3), 2153911 (2), 2129393 (2), 1688464 (1) (see all 43) |
Search CenterWatch for drugs/clinical trials and news about ADCY10 / ADCYA
|
Transcripts
for ADCY10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADCY10 gene (2 alternative transcripts): NM_001167749.1 NM_018417.4 Unigene Cluster for ADCY10: Adenylate cyclase 10 (soluble) Hs.320892 [show with all ESTs]Unigene Representative Sequence: NM_0184175 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367851(uc001ger.3 uc009wvl.3 uc009wvm.2) ENST00000485964
ENST00000367848(uc009wvk.3) ENST00000476818 ENST00000545172(uc009wvj.3 uc010plj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY10 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ADCY10 (NM_018417) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCY10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY10 |
Additional cDNA sequence: AF176813.2 AF271058.1 AF299350.1 AF331033.1 AK302884.1 AK310395.1 AK310531.1 AL035122.1 BC117366.1 BC117372.1 3 DOTS entries: DT.91666152 DT.75172523 DT.86842885 11 AceView cDNA sequences: AF299350 AL035122 AW592474 NM_018417 AF176813 AF271058 AF331033 AI243150 BX098895 BU561368 AA707634
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ADCY10 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | · | 15c | ^ | 16 | ^ | 17 | ^ | 18 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ADCY10
|
Expression
for ADCY10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADCY10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAAAGAAAA
About this image
See ADCY10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCY10
SOURCE GeneReport for Unigene cluster: Hs.320892
UniProtKB/Swiss-Prot: ADCYA_HUMAN, Q96PN6Tissue specificity: Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas,peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunumand ileum. Very low level of expression in bone
SABiosciences Custom PCR Arrays for ADCY10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY10
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY10 |
Orthologs
for ADCY10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADCY10 gene from 4/19 species (see all 19) About this table
ENSEMBL Gene Tree for ADCY10 (if available)
TreeFam Gene Tree for ADCY10 (if available) |
Paralogs
for ADCY10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADCY10 gene
ADCY10 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ADCY10
PGOHUM00000243618
|
Genomic Variants
for ADCY10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADCY10 (167778625 - 167883453 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ADCY10
1 CNV: 6794
Human Gene Mutation Database (HGMD): ADCY10
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCY10 |
|
Disorders
/ Diseases
for ADCY10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADCY10 for disorders About GeneDecksing
OMIM gene information: 605205
OMIM disorders: 143870
UniProtKB/Swiss-Prot: ADCYA_HUMAN, Q96PN6
Genetic variations in ADCY10 are a cause of susceptibility to hypercalciuria absorptive type 2 (HCA2)[MIM:143870]. Absorptive hypercalciuria is a common type of hypercalciuria, a condition characterized by excessiveurinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is afrequent cause of calcium oxalate nephrolithiasis
20/138  diseases for ADCY10 (see all 138): About MalaCardshypercalciuria hypercalciuria, absorptive obsessive-compulsive disorder mitral valve prolapse
multinodular goiter albright's hereditary osteodystrophy adenomatous polyposis coli leydig cell tumor
pseudohypoparathyroidism pre-eclampsia humoral hypercalcemia of malignancy morphine dependence
fibrous dysplasia ventricular tachycardia opiate dependence bipolar affective disorder
adrenal adenoma congestive heart failure goiter dilated cardiomyopathy
1 disease from the University of Copenhagen DISEASES database for ADCY10:Cholera 10/91 Novoseek disease relationships for ADCY10 gene (see all 91) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| platelet adenylate cyclase activity |
76.9 |
1 |
2175792 (1) |
| cholera |
76.7 |
68 |
1673334 (5), 2119204 (3), 8554518 (2), 1682005 (1) (see all 57) |
| pseudohypoparathyroidism |
61.1 |
5 |
19381884 (1), 7702269 (1), 8397330 (1), 10518972 (1) (see all 5) |
| pseudohypoparathyroidism, type ii |
57.2 |
1 |
10518973 (1) |
| osteosarcoma |
41.7 |
9 |
2405851 (1), 2161222 (1), 1651438 (1), 8825419 (1) (see all 9) |
| glioma |
37.9 |
19 |
1673334 (2), 7972932 (2), 2119204 (2), 2175190 (1) (see all 14) |
| graves disease |
35.7 |
7 |
2170263 (1), 1312488 (1), 1673689 (1), 8094393 (1) (see all 7) |
| toxic goiter |
28.3 |
1 |
8626855 (1) |
| insulinoma |
26.7 |
1 |
7813816 (1) |
| anthrax |
24.2 |
1 |
11867750 (1) |
Human Genome Epidemiology (HuGE) Navigator: ADCY10 (4 documents)
Export disorders for ADCY10 gene to outside databases
|
Publications
for ADCY10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADCY10 gene, integrated from 9 sources (see all 1481):
(articles sorted by number of sources associating them with ADCY10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate. (PubMed id 12609998)1, 2, 9 Litvin T.N.... Levin L.R. (2003)
- Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. (PubMed id 17591988)1, 2, 9 Schmid A.... Salathe M. (2007)
- Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. (PubMed id 12475901)1, 2 Zippin J.H.... Buck J. (2003)
- Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. (PubMed id 11932268)1, 2 Reed B.Y....Pak C.Y.C. (2002)
- Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. (PubMed id 11423534)1, 2 Jaiswal B.S. and Conti M. (2001)
- Soluble adenylyl cyclase defines a nuclear cAMP micro domain in keratinocyte hyperproliferative skin diseases. (PubMed id 20130594)1, 9 Zippin J.H....Magro C.M. (2010)
- Calcium regulation of the soluble adenylyl cyclase expressed in mammalian spermatozoa. (PubMed id 12958208)1, 9 Jaiswal B.S. and Conti M. (2003)
- Bicarbonate-regulated soluble adenylyl cyclase. (PubMed id 11875252)1, 9 Wuttke M.S....Levin L.R. (2001)
- Regulation of anterior chamber drainage by bicarbonat e-sensitive soluble adenylyl cyclase in the ciliary body. (PubMed id 21994938)1 Lee Y.S....Marmorstein A.D. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
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External Searches for ADCY10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ADCY10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ADCY10 gene
(According to HUGE)
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Specialized Databases showing ADCY10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ADCY10 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for ADCY10 gene:
Search GeneIP for patents involving ADCY10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ADCY10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADCY10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY10 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADCY10 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADCY10 | | OriGene Custom Protein Services for ADCY10 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADCY10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCY10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY10 |
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| | | | Search Tocris compounds for ADCY10 |
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 | | | ADCY10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY10 |
|  |  |  | | | | ThermoFisher Antibodies for ADCY10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCY10 |
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