Aliases for ADCY10 Gene
External Ids for ADCY10 Gene
The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
GeneCards Summary for ADCY10 Gene
ADCY10 (Adenylate Cyclase 10 (Soluble)) is a Protein Coding gene. Diseases associated with ADCY10 include idiopathic hypercalciuria and cholera. Among its related pathways are Activation of cAMP-Dependent PKA and Activation of cAMP-Dependent PKA. GO annotations related to this gene include magnesium ion binding and ATPase binding.
UniProtKB/Swiss-Prot for ADCY10 Gene
Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.