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Aliases for ADCY10 Gene

Aliases for ADCY10 Gene

  • Adenylate Cyclase 10 (Soluble) 2 3
  • Germ Cell Soluble Adenylyl Cyclase 3 4
  • AH-Related Protein 3 4
  • EC 4.6.1.1 4 63
  • HsAC 3 4
  • SAC 3 4
  • Epididymis Secretory Sperm Binding Protein Li 7a 3
  • Testicular Soluble Adenylyl Cyclase (SAC) 3
  • Testicular Soluble Adenylyl Cyclase 4
  • 3,5-Cyclic AMP Synthetase 3
  • Adenylate Cyclase Homolog 4
  • Soluble Adenylyl Cyclase 2
  • ATP Pyrophosphate-Lyase 3
  • Hypercalciuria 2
  • Absorptive 2
  • HEL-S-7a 3
  • HCA2 3
  • SACI 3
  • Sacy 3
  • 2 2

External Ids for ADCY10 Gene

Previous GeneCards Identifiers for ADCY10 Gene

  • GC01M166046
  • GC01M139024

Summaries for ADCY10 Gene

Entrez Gene Summary for ADCY10 Gene

  • The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

GeneCards Summary for ADCY10 Gene

ADCY10 (Adenylate Cyclase 10 (Soluble)) is a Protein Coding gene. Diseases associated with ADCY10 include hypercalciuria, absorptive and idiopathic hypercalciuria. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. GO annotations related to this gene include magnesium ion binding and manganese ion binding.

UniProtKB/Swiss-Prot for ADCY10 Gene

  • Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).

Gene Wiki entry for ADCY10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY10 Gene

Genomics for ADCY10 Gene

Regulatory Elements for ADCY10 Gene

Genomic Location for ADCY10 Gene

Chromosome:
1
Start:
167,809,080 bp from pter
End:
167,915,526 bp from pter
Size:
106,447 bases
Orientation:
Minus strand

Genomic View for ADCY10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCY10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY10 Gene

Proteins for ADCY10 Gene

  • Protein details for ADCY10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PN6-ADCYA_HUMAN
    Recommended name:
    Adenylate cyclase type 10
    Protein Accession:
    Q96PN6
    Secondary Accessions:
    • B4DZF0
    • F5GWS5
    • O95558
    • Q5R329
    • Q5R330
    • Q8WXV4
    • Q9NNX0

    Protein attributes for ADCY10 Gene

    Size:
    1610 amino acids
    Molecular mass:
    187149 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds 2 magnesium ions per subunit (PubMed:25040695). Is also active with manganese (in vitro) (PubMed:12609998, PubMed:15659711, PubMed:24616449).;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADCY10 Gene

    Alternative splice isoforms for ADCY10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY10 Gene

Proteomics data for ADCY10 Gene at MOPED

Post-translational modifications for ADCY10 Gene

Other Protein References for ADCY10 Gene

Antibody Products

Domains & Families for ADCY10 Gene

Gene Families for ADCY10 Gene

Suggested Antigen Peptide Sequences for ADCY10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PN6

UniProtKB/Swiss-Prot:

ADCYA_HUMAN :
  • The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments or isoforms containing the first 470 amino acid residues are fully active.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments or isoforms containing the first 470 amino acid residues are fully active.
  • Contains 2 guanylate cyclase domains.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY10: view

Function for ADCY10 Gene

Molecular function for ADCY10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 mM for ATP-Mn(2+) {ECO:0000269 PubMed:12609998}; KM=2.41 mM for Mg(2+) {ECO:0000269 PubMed:12609998};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by manganese or magnesium ions (PubMed:12609998, PubMed:24616449). In the presence of magnesium ions, the enzyme is activated by bicarbonate (PubMed:12609998, PubMed:15659711, PubMed:24567411). In the presence of manganese ions, the enzyme is inhibited by bicarbonate (PubMed:15659711). In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium (PubMed:15659711). Calcium mildly increases the enzyme activity, also in the presence of magnesium ions (PubMed:15659711, PubMed:25040695).
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).

Enzyme Numbers (IUBMB) for ADCY10 Gene

Gene Ontology (GO) - Molecular Function for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004016 adenylate cyclase activity NAS 9874775
GO:0005524 ATP binding IEA --
GO:0016849 phosphorus-oxygen lyase activity --
GO:0030145 manganese ion binding IEA --
genes like me logo Genes that share ontologies with ADCY10: view
genes like me logo Genes that share phenotypes with ADCY10: view

Animal Models for ADCY10 Gene

MGI Knock Outs for ADCY10:

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY10

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for ADCY10 Gene

Localization for ADCY10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY10 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus. Cell projection, cilium. Cytoplasm. Mitochondrion. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. {ECO:0000269 PubMed:12475901, ECO:0000269 PubMed:15659711}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCY10 Gene COMPARTMENTS Subcellular localization image for ADCY10 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 5
chloroplast 2
mitochondrion 2
extracellular 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15659711
GO:0005737 cytoplasm TAS 9874775
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol NAS 9874775
GO:0005856 cytoskeleton --
genes like me logo Genes that share ontologies with ADCY10: view

Pathways & Interactions for ADCY10 Gene

genes like me logo Genes that share pathways with ADCY10: view

Pathways by source for ADCY10 Gene

SIGNOR curated interactions for ADCY10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IMP 17591988
GO:0006171 cAMP biosynthetic process NAS 9874775
GO:0007283 spermatogenesis IEA --
GO:0009190 cyclic nucleotide biosynthetic process --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ADCY10: view

Drugs & Compounds for ADCY10 Gene

(81) Drugs for ADCY10 Gene - From: NovoSeek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Amrinone Approved Pharma 0
Atropine Approved Pharma Antagonist MAChRs antagonist 101
Brimonidine Approved Pharma Partial agonist, Agonist 108
Bromocriptine Approved, Investigational Pharma Partial agonist, Agonist 27

(54) Additional Compounds for ADCY10 Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
(R)-(Phenylisopropyl)adenosine
[3h]diprenorphine
1,9-Dideoxyforskolin
12-O-Tetradecanoylphorbol 13-acetate
genes like me logo Genes that share compounds with ADCY10: view

Transcripts for ADCY10 Gene

Unigene Clusters for ADCY10 Gene

Adenylate cyclase 10 (soluble):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCY10

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -
SP6: -
SP7:
SP8: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for ADCY10 Gene

GeneLoc Exon Structure for
ADCY10
ECgene alternative splicing isoforms for
ADCY10

Expression for ADCY10 Gene

mRNA expression in normal human tissues for ADCY10 Gene

mRNA differential expression in normal tissues according to GTEx for ADCY10 Gene

This gene is overexpressed in Testis (x23.6) and Liver (x9.7).

Protein differential expression in normal tissues from HIPED for ADCY10 Gene

This gene is overexpressed in Testis (38.9), Liver, secretome (12.3), Plasma (9.2), and Neutrophil (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCY10 Gene



SOURCE GeneReport for Unigene cluster for ADCY10 Gene Hs.320892

mRNA Expression by UniProt/SwissProt for ADCY10 Gene

Q96PN6-ADCYA_HUMAN
Tissue specificity: Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.
genes like me logo Genes that share expression patterns with ADCY10: view

Protein tissue co-expression partners for ADCY10 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADCY10 Gene

Orthologs for ADCY10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADCY10 35
  • 85.65 (n)
  • 79.88 (a)
ADCY10 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY10 35
  • 86.13 (n)
  • 80.5 (a)
ADCY10 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adcy10 35
  • 81.77 (n)
  • 77.67 (a)
Adcy10 16
Adcy10 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADCY10 35
  • 99.25 (n)
  • 98.76 (a)
ADCY10 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy10 35
  • 81.35 (n)
  • 77.6 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCY10 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
chicken
(Gallus gallus)
Aves LOC101751665 35
  • 63.25 (n)
  • 47.44 (a)
-- 36
  • 31 (a)
OneToMany
-- 36
  • 34 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 40 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ADCY10 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008683 35
  • 47.79 (n)
  • 33.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for ADCY10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADCY10 Gene

ENSEMBL:
Gene Tree for ADCY10 (if available)
TreeFam:
Gene Tree for ADCY10 (if available)

Paralogs for ADCY10 Gene

Pseudogenes.org Pseudogenes for ADCY10 Gene

genes like me logo Genes that share paralogs with ADCY10: view

No data available for Paralogs for ADCY10 Gene

Variants for ADCY10 Gene

Sequence variations from dbSNP and Humsavar for ADCY10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs129717 -- 167,869,566(+) taagc(C/T)tggta intron-variant
rs129718 -- 167,869,567(+) AAGCC(C/T)GGTAG intron-variant
rs189958 -- 167,851,350(-) aatta(C/G)ccggg intron-variant
rs203773 -- 167,898,921(+) TCAAT(C/G)TGCAA intron-variant
rs203774 -- 167,902,327(+) GAGGT(A/C)TGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY10 Gene

Variant ID Type Subtype PubMed ID
esv32660 CNV Loss 17666407
nsv527119 CNV Loss 19592680
nsv464239 CNV Loss 19166990
esv273284 CNV Insertion 20981092
esv267723 CNV Insertion 20981092
esv2719217 CNV Deletion 23290073

Variation tolerance for ADCY10 Gene

Residual Variation Intolerance Score: 76.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCY10 Gene

HapMap Linkage Disequilibrium report
ADCY10
Human Gene Mutation Database (HGMD)
ADCY10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY10 Gene

Disorders for ADCY10 Gene

MalaCards: The human disease database

(16) MalaCards diseases for ADCY10 Gene - From: OMIM, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
hypercalciuria, absorptive
  • hypercalciuria, absorptive, susceptibility to
idiopathic hypercalciuria
pseudohypoparathyroidism type 2
  • php ii
conjunctival folliculosis
  • acute follicular conjunctivitis
brain ischemia
- elite association

UniProtKB/Swiss-Prot

ADCYA_HUMAN
  • Hypercalciuria absorptive 2 (HCA2) [MIM:143870]: A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. {ECO:0000269 PubMed:11932268}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ADCY10

Genetic Association Database (GAD)
ADCY10
Human Genome Epidemiology (HuGE) Navigator
ADCY10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY10
genes like me logo Genes that share disorders with ADCY10: view

No data available for Genatlas for ADCY10 Gene

Publications for ADCY10 Gene

  1. Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis. (PMID: 20018667) Tresguerres M. … Buck J. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  2. Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases. (PMID: 20130594) Zippin J.H. … Magro C.M. (J. Invest. Dermatol. 2010) 23 67
  3. Tyrphostins as potential therapeutic agents for acute kidney injury. (PMID: 20156166) GonAsalves S. … Ortiz A. (Curr. Med. Chem. 2010) 23 67
  4. Adenosine suppresses CW2 human colonic cancer growth by inducing apoptosis via A(1) adenosine receptors. (PMID: 19822392) Saito M. … Nishizaki T. (Cancer Lett. 2010) 23 67
  5. Inhibition of heat shock protein 90 attenuates adenylate cyclase sensitization after chronic morphine treatment. (PMID: 20100459) Koshimizu T.A. … Fujimura A. (Biochem. Biophys. Res. Commun. 2010) 23 67

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