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Aliases for ADCY10 Gene

Aliases for ADCY10 Gene

  • Adenylate Cyclase 10, Soluble 2 3 5
  • Germ Cell Soluble Adenylyl Cyclase 3 4
  • AH-Related Protein 3 4
  • EC 4.6.1.1 4 58
  • HsAC 3 4
  • SAC 3 4
  • Epididymis Secretory Sperm Binding Protein Li 7a 3
  • Testicular Soluble Adenylyl Cyclase (SAC) 3
  • Testicular Soluble Adenylyl Cyclase 4
  • Hypercalciuria, Absorptive, 2 2
  • 3,5-Cyclic AMP Synthetase 3
  • Adenylate Cyclase Type 10 3
  • Adenylate Cyclase Homolog 4
  • Soluble Adenylyl Cyclase 2
  • ATP Pyrophosphate-Lyase 3
  • HEL-S-7a 3
  • HCA2 3
  • SACI 3
  • Sacy 3

External Ids for ADCY10 Gene

Previous GeneCards Identifiers for ADCY10 Gene

  • GC01M166046
  • GC01M139024

Summaries for ADCY10 Gene

Entrez Gene Summary for ADCY10 Gene

  • The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

GeneCards Summary for ADCY10 Gene

ADCY10 (Adenylate Cyclase 10, Soluble) is a Protein Coding gene. Diseases associated with ADCY10 include Hypercalciuria, Absorptive and Idiopathic Hypercalciuria. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Sweet Taste Signaling. GO annotations related to this gene include magnesium ion binding and manganese ion binding.

UniProtKB/Swiss-Prot for ADCY10 Gene

  • Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).

Gene Wiki entry for ADCY10 Gene

Additional gene information for ADCY10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCY10 Gene

Genomics for ADCY10 Gene

Regulatory Elements for ADCY10 Gene

Enhancers for ADCY10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H167985 1.1 FANTOM5 21.2 -69.6 -69560 0 HDGF PKNOX1 ARNT FEZF1 ZNF2 ZNF766 CBX5 ZNF302 ZNF416 ZNF548 POU2F1 MPZL1 ADCY10 LOC441914 RPL29P7 ENSG00000272205 MPC2 RCSD1 GC01P167995
GH01H167713 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +200.2 200226 4 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 ZC3H11A ZFP41 MEF2D POU2F1 MPZL1 TADA1 LOC441914 CNN2P10 FMO11P ADCY10 DUTP6 TIPRL CREG1
GH01H167445 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +463.3 463295 13 PKNOX1 ATF1 SIN3A FEZF1 GLI4 ZNF2 YY1 ZNF766 GLIS2 GATA2 CD247 CNN2P10 FMO11P LOC441914 FMO10P ENSG00000225325 AKR1D1P1 CREG1 ADCY10 GPA33
GH01H167658 1.5 Ensembl ENCODE dbSUPER 10.8 +256.1 256125 1 PKNOX1 ARNT FEZF1 ZNF2 GLIS2 KLF7 TSHZ1 ZNF488 SMARCB1 ZNF518A POU2F1 LOC441914 FMO11P CNN2P10 RCSD1 ADCY10 ENSG00000241666 TRP-CGG1-1
GH01H167160 1.5 Ensembl ENCODE dbSUPER 10.8 +753.2 753164 2 PKNOX1 ATF1 FEZF1 ZNF2 ZNF766 ZNF302 KLF7 CAVIN1 TSHZ1 ZNF488 ENSG00000230898 CNN2P10 FMO11P FMO10P ENSG00000225325 ADCY10 FAM78B TADA1 GC01P167158 RPS17P6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADCY10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADCY10 Gene

Chromosome:
1
Start:
167,809,080 bp from pter
End:
167,915,526 bp from pter
Size:
106,447 bases
Orientation:
Minus strand

Genomic View for ADCY10 Gene

Genes around ADCY10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCY10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCY10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCY10 Gene

Proteins for ADCY10 Gene

  • Protein details for ADCY10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PN6-ADCYA_HUMAN
    Recommended name:
    Adenylate cyclase type 10
    Protein Accession:
    Q96PN6
    Secondary Accessions:
    • B4DZF0
    • F5GWS5
    • O95558
    • Q5R329
    • Q5R330
    • Q8WXV4
    • Q9NNX0

    Protein attributes for ADCY10 Gene

    Size:
    1610 amino acids
    Molecular mass:
    187149 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ADCY10 Gene

    Alternative splice isoforms for ADCY10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCY10 Gene

Selected DME Specific Peptides for ADCY10 Gene

Q96PN6:
  • DIFDFCSQVHKI
  • LVAQNTTGPVF
  • TVSIGVASGIVFCGIVGHTVRHEYTVIGQKVN
  • EKVMFGMA
  • SRYMEGQVL
  • LSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIK
  • AMYMDRGAEQLVEILNY
  • GYLSELRPVTIVFVNLMF
  • YFFKELPKK
  • GQINKVFMFDKGCSFLCVFGFPGEK
  • ISAIVEKVLIFGGDILKFAGDALLALW
  • MANVLGLDTCKHYKERQTNL

Post-translational modifications for ADCY10 Gene

Domains & Families for ADCY10 Gene

Gene Families for ADCY10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for ADCY10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PN6

UniProtKB/Swiss-Prot:

ADCYA_HUMAN :
  • The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments or isoforms containing the first 470 amino acid residues are fully active.
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
Domain:
  • The N-terminal guanylate cyclase domains are required for enzyme activity. Fragments or isoforms containing the first 470 amino acid residues are fully active.
Family:
  • Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.
genes like me logo Genes that share domains with ADCY10: view

Function for ADCY10 Gene

Molecular function for ADCY10 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.8 mM for ATP-Mn(2+) {ECO:0000269 PubMed:12609998}; KM=2.41 mM for Mg(2+) {ECO:0000269 PubMed:12609998};
UniProtKB/Swiss-Prot CatalyticActivity:
ATP = 3,5-cyclic AMP + diphosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by manganese or magnesium ions (PubMed:12609998, PubMed:24616449). In the presence of magnesium ions, the enzyme is activated by bicarbonate (PubMed:12609998, PubMed:15659711, PubMed:24567411). In the presence of manganese ions, the enzyme is inhibited by bicarbonate (PubMed:15659711). In the absence of magnesium and bicarbonate, the enzyme is weakly activated by calcium (PubMed:15659711). Calcium mildly increases the enzyme activity, also in the presence of magnesium ions (PubMed:15659711, PubMed:25040695).
UniProtKB/Swiss-Prot Function:
Catalyzes the formation of the signaling molecule cAMP (PubMed:12609998, PubMed:15659711, PubMed:24616449, PubMed:25040695, PubMed:24567411). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (PubMed:15659711, PubMed:17591988). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (PubMed:17591988).

Enzyme Numbers (IUBMB) for ADCY10 Gene

Phenotypes From GWAS Catalog for ADCY10 Gene

Gene Ontology (GO) - Molecular Function for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004016 adenylate cyclase activity NAS,TAS 9874775
GO:0005524 ATP binding IEA --
GO:0016829 lyase activity IEA --
GO:0016849 phosphorus-oxygen lyase activity IEA --
genes like me logo Genes that share ontologies with ADCY10: view
genes like me logo Genes that share phenotypes with ADCY10: view

Human Phenotype Ontology for ADCY10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ADCY10 Gene

MGI Knock Outs for ADCY10:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCY10

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADCY10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for miRNA , Transcription Factor Targets and HOMER Transcription for ADCY10 Gene

Localization for ADCY10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCY10 Gene

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Nucleus. Cell projection, cilium. Cytoplasm. Mitochondrion. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. {ECO:0000269 PubMed:12475901, ECO:0000269 PubMed:15659711}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCY10 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 4
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 15659711
GO:0005737 cytoplasm TAS 9874775
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol NAS 9874775
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with ADCY10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ADCY10 Gene

Pathways & Interactions for ADCY10 Gene

genes like me logo Genes that share pathways with ADCY10: view

SIGNOR curated interactions for ADCY10 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ADCY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003351 epithelial cilium movement IMP 17591988
GO:0006171 cAMP biosynthetic process NAS 9874775
GO:0007283 spermatogenesis IEA --
GO:0009190 cyclic nucleotide biosynthetic process IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ADCY10: view

Drugs & Compounds for ADCY10 Gene

(90) Drugs for ADCY10 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Manganese Approved Nutra 35
cyclic amp Experimental Pharma 0
Cyclic GMP Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
1,9-Dideoxyforskolin Pharma 0

(50) Additional Compounds for ADCY10 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Hydrogen carbonate
  • Bicarbonate
  • Bicarbonate (HCO3-)
  • Bicarbonate anion
  • Bicarbonate ion
  • Bicarbonate ion (HCO31-)
71-52-3
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8

(8) ApexBio Compounds for ADCY10 Gene

Compound Action Cas Number
1,9-Dideoxyforskolin 64657-18-7
Forskolin 66575-29-9
KH 7 330676-02-3
MDL 12330A hydrochloride adenylate cyclase inhibitor 40297-09-4
N6-methyladenosine (m6A) adenylate cyclase regulator 1867-73-8
NKH 477 138605-00-2
NKY 80 299442-43-6
SQ 22536 17318-31-9
genes like me logo Genes that share compounds with ADCY10: view

Drug Products

Transcripts for ADCY10 Gene

mRNA/cDNA for ADCY10 Gene

Unigene Clusters for ADCY10 Gene

Adenylate cyclase 10 (soluble):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ADCY10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ADCY10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b · 15c ^ 16 ^ 17 ^ 18 ^
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: -
SP6: -
SP7:
SP8: -

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35 ^ 36a · 36b
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5:
SP6:
SP7: - -
SP8:

Relevant External Links for ADCY10 Gene

GeneLoc Exon Structure for
ADCY10
ECgene alternative splicing isoforms for
ADCY10

Expression for ADCY10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCY10 Gene

mRNA differential expression in normal tissues according to GTEx for ADCY10 Gene

This gene is overexpressed in Testis (x23.6) and Liver (x9.7).

Protein differential expression in normal tissues from HIPED for ADCY10 Gene

This gene is overexpressed in Testis (38.9), Liver, secretome (12.3), Plasma (9.2), and Neutrophil (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCY10 Gene



Protein tissue co-expression partners for ADCY10 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADCY10 Gene:

ADCY10

SOURCE GeneReport for Unigene cluster for ADCY10 Gene:

Hs.320892

mRNA Expression by UniProt/SwissProt for ADCY10 Gene:

Q96PN6-ADCYA_HUMAN
Tissue specificity: Detected in airway epithelial cells and testis (at protein level) (PubMed:17591988). Weakly expressed in multiple tissues. Expressed in brain, heart, kidney, liver, lung, pancreas, peripheral blood leukocytes, placenta, skeletal muscle, stomach, thymus, airway epithelial cells, duodenum, jejunum and ileum. Very low level of expression in bone.

Evidence on tissue expression from TISSUES for ADCY10 Gene

  • Intestine(4.3)
  • Kidney(2.7)
  • Urine(2.5)
  • Blood(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCY10 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • skeletal muscle
  • urinary
Organs:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • heart
Abdomen:
  • duodenum
  • intestine
  • kidney
  • large intestine
  • pancreas
  • small intestine
  • stomach
Pelvis:
  • rectum
  • ureter
genes like me logo Genes that share expression patterns with ADCY10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ADCY10 Gene

Orthologs for ADCY10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADCY10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCY10 34 33
  • 99.25 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ADCY10 33 34
  • 86.13 (n)
cow
(Bos Taurus)
Mammalia ADCY10 33 34
  • 85.65 (n)
mouse
(Mus musculus)
Mammalia Adcy10 34 16 33
  • 81.77 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adcy10 33
  • 81.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 67 (a)
OneToMany
-- 34
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia ADCY10 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101751665 33
  • 63.25 (n)
-- 34
  • 40 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
-- 34
  • 35 (a)
OneToMany
-- 34
  • 34 (a)
OneToMany
-- 34
  • 32 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ADCY10 34
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008683 33
  • 47.79 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for ADCY10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ADCY10 Gene

ENSEMBL:
Gene Tree for ADCY10 (if available)
TreeFam:
Gene Tree for ADCY10 (if available)

Paralogs for ADCY10 Gene

Pseudogenes.org Pseudogenes for ADCY10 Gene

genes like me logo Genes that share paralogs with ADCY10: view

No data available for Paralogs for ADCY10 Gene

Variants for ADCY10 Gene

Sequence variations from dbSNP and Humsavar for ADCY10 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000010148 -- 167,910,092(+) CTTGA(G/T)ATGCA intron-variant
rs1000024035 -- 167,867,244(+) TGGGA(A/G)CAGCT intron-variant
rs1000029623 -- 167,826,439(+) ATTCT(C/T)CCATG intron-variant
rs1000089911 -- 167,901,732(+) AGGCT(A/G)CATTT intron-variant, nc-transcript-variant, reference, synonymous-codon
rs1000092435 -- 167,825,766(+) CCTGG(A/G)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCY10 Gene

Variant ID Type Subtype PubMed ID
esv2719217 CNV deletion 23290073
esv32660 CNV loss 17666407
esv3309011 CNV mobile element insertion 20981092
esv3328988 CNV insertion 20981092
esv3330175 CNV duplication 20981092
esv3427330 CNV insertion 20981092
nsv1002698 CNV loss 25217958
nsv1078878 OTHER inversion 25765185
nsv464239 CNV loss 19166990
nsv527119 CNV loss 19592680
nsv548132 CNV loss 21841781

Variation tolerance for ADCY10 Gene

Residual Variation Intolerance Score: 76.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.40; 71.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCY10 Gene

Human Gene Mutation Database (HGMD)
ADCY10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCY10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCY10 Gene

Disorders for ADCY10 Gene

MalaCards: The human disease database

(20) MalaCards diseases for ADCY10 Gene - From: HGMD, OMIM, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hypercalciuria, absorptive
  • hypercalciuria, absorptive 2
idiopathic hypercalciuria
cholera
  • cholera - vibrio cholerae
brain ischemia
pseudohypoparathyroidism, type ii
  • pseudohypoparathyroidism type 2
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ADCYA_HUMAN
  • Hypercalciuria absorptive 2 (HCA2) [MIM:143870]: A common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. {ECO:0000269 PubMed:11932268}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ADCY10

Genetic Association Database (GAD)
ADCY10
Human Genome Epidemiology (HuGE) Navigator
ADCY10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCY10
genes like me logo Genes that share disorders with ADCY10: view

No data available for Genatlas for ADCY10 Gene

Publications for ADCY10 Gene

  1. Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. (PMID: 17591988) Schmid A … Salathe M (The Journal of general physiology 2007) 3 4 22 60
  2. Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. (PMID: 12609998) Litvin TN … Levin LR (The Journal of biological chemistry 2003) 3 4 22 60
  3. Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate. (PMID: 24567411) Kleinboelting S … Steegborn C (Proceedings of the National Academy of Sciences of the United States of America 2014) 3 4 60
  4. Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution. (PMID: 25040695) Kleinboelting S … Steegborn C (The FEBS journal 2014) 3 4 60
  5. Type 10 soluble adenylyl cyclase is overexpressed in prostate carcinoma and controls proliferation of prostate cancer cells. (PMID: 23255611) Flacke JP … Ladilov Y (The Journal of biological chemistry 2013) 2 3 60

Products for ADCY10 Gene

Sources for ADCY10 Gene

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