Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCY1 Gene

protein-coding   GIFtS: 66
GCID: GC07P045580

Adenylate Cyclase 1 (Brain)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenylate Cyclase 1 (Brain)1 2     EC 4.6.1.13 8
Adenylate Cyclase Type I2 3     3',5'-Cyclic AMP Synthetase2
Adenylyl Cyclase 12 3     AC12
ATP Pyrophosphate-Lyase 12 3     Adenyl Cyclase2
Ca(2+)/Calmodulin-Activated Adenylyl Cyclase2 3     Adenylate Cyclase Type 12

External Ids:    HGNC: 2321   Entrez Gene: 1072   Ensembl: ENSG000001647427   OMIM: 1030725   UniProtKB: Q088283   

Export aliases for ADCY1 gene to outside databases

Previous GC identifers: GC07P045296 GC07P045354 GC07P045387


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCY1 Gene:
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This
protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate
splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for ADCY1 Gene: 
ADCY1 (adenylate cyclase 1 (brain)) is a protein-coding gene. Diseases associated with ADCY1 include mccune albright syndrome, and adenoma, and among its related super-pathways are PKA activation in glucagon signalling and DAG and IP3 signaling. GO annotations related to this gene include calcium- and calmodulin-responsive adenylate cyclase activity and calmodulin binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central
nervous system. It may play a role in memory acquisition and learning

summary for ADCY1 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCY1 gene promoter:
         GR   FOXF2   NF-AT   CREB   FAC1   NF-AT2   deltaCREB   Chx10   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): ADCY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p13-p12

ADCY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P045580:  view genomic region     (about GC identifiers)

Start:
45,613,739 bp from pter      End:
45,762,715 bp from pter
Size:
148,977 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 45,653,346-45,802,046     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828 (See protein sequence)
Recommended Name: Adenylate cyclase type 1  
Size: 1119 amino acids; 123440 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A4D2L8 Q75MI1

Explore the universe of human proteins at neXtProt for ADCY1: NX_Q08828

Explore proteomics data for ADCY1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q08828

  • 4/14 DME Specific Peptides for ADCY1 (Q08828) (see all 14)
     WQYDVWS  ADIVGFT  FHKIYIQ  TVNVASR 

    ADCY1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADCY1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001268697.1  NP_066939.1  

    ENSEMBL proteins: 
     ENSP00000392721   ENSP00000297323  
    Reactome Protein details: Q08828
    Human Recombinant Protein Products for ADCY1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ADCY1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ADCY1
    GenScript Custom Purified and Recombinant Proteins Services for ADCY1
    Novus Biologicals ADCY1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS--

    ADCY1 for ontologies           About GeneDecksing



    ADCY1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ADCY1
    GenScript Custom Superior Antibodies Services for ADCY1
    Novus Biologicals ADCY1 Antibodies
    Abcam antibodies for ADCY1
    Cloud-Clone Corp. Antibodies for ADCY1 
    ThermoFisher Antibodies for ADCY1
    LSBio Antibodies in human, mouse, rat for ADCY1 

    Assay Products for ADCY1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ADCY1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADCY1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADCY1 
    Cloud-Clone Corp. CLIAs for ADCY1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC1 
    Adenylyl cyclases

    2 InterPro protein domains:
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q08828

    ProtoNet protein and cluster: Q08828

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    ADCY1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY1_HUMAN, Q08828
    Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central
    nervous system. It may play a role in memory acquisition and learning
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex

         Genatlas biochemistry entry for ADCY1:
    adenylyl cyclase,type I,calmodulin sensitive,fetal brain

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity ----
    GO:0005516calmodulin binding NAS--
    GO:0005524ATP binding IEA--
    GO:0008294calcium- and calmodulin-responsive adenylate cyclase activity NAS8314585
         
    ADCY1 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adcy1):
     behavior/neurological  homeostasis/metabolism  integument  nervous system 

    ADCY1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ADCY1: Adcy1tm1.1Ito Adcy1tm1Drs

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADCY1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADCY1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADCY1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ADCY1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY1
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY1 (see all 109):
    hsa-miR-124* hsa-miR-3130-5p hsa-miR-199a-3p hsa-miR-4272 hsa-miR-3653 hsa-miR-374a hsa-miR-4275 hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADCY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADCY1
    Sirion Biotech Customized adenovirus for overexpression of ADCY1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ADCY1 (see all 7)
    OriGene ORF clones in mouse, rat for ADCY1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY1 (NM_021116)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY1
    Sirion Biotech Customized lentivirus for stable overexpression of ADCY1 
                         Customized lentivirus expression plasmids for stable overexpression of ADCY1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADCY1
    Search LifeMap BioReagents cell lines for ADCY1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADCY1 About   (see all 76)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1PKA activation in glucagon signalling
    PKA activation in glucagon signalling0.94
    Neurophysiological process PGE2-induced pain processing0.44
    PKA-mediated phosphorylation of CREB0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.38
    PKA activation0.94
    Development Role of Activin A in cell differentiation and proliferation0.33
    Regulation of CFTR gating (normal and CF)0.80
    Development Beta-adrenergic receptors signaling via cAMP0.32
    2Ca-dependent events
    DAG and IP3 signaling0.94
    PLCG1 events in ERBB2 signaling0.91
    EGFR interacts with phospholipase C-gamma0.94
    PLC beta mediated events0.65
    PLC-gamma1 signalling0.94
    G-protein mediated events0.64
    Ca-dependent events0.93
    Phospholipase C-mediated cascade0.57
    3Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.84
    G alpha (z) signalling events0.49
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    4Adenylate cyclase activating pathway
    Adenylate cyclase activating pathway0.71
    Inhibition of adenylate cyclase pathway0.71
    Adenylate cyclase inhibitory pathway0.71
    LPA4-mediated signaling events0.67
    5Development Endothelin-1/EDNRA signaling
    Development Endothelin-1/EDNRA signaling0.41
    Estrogen signaling pathway0.34
    GnRH signaling pathway0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/21 EMD Millipore Pathways for ADCY1 (see all 21)
        Adenylate cyclase-activating neuropeptides
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling
    Transcription PPAR Pathway
    Development Role of Activin A in cell differentiation and proliferation

    5/44 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY1 (see all 44)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    PACAP Signaling
    P2Y Receptor Signaling

    5/24 GeneGo (Thomson Reuters) Pathways for ADCY1 (see all 24)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Transcription PPAR Pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    G-protein signaling G-Protein alpha-i signaling cascades

    5/7 BioSystems Pathways for ADCY1 (see all 7)
        Myometrial Relaxation and Contraction Pathways
    Hypothetical Network for Drug Addiction
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events

    5/53        Reactome Pathways for ADCY1 (see all 53)
        PKA activation
    Signaling by EGFR in Cancer
    Post NMDA receptor activation events
    G alpha (z) signalling events
    Downstream signal transduction

    3 PharmGKB Pathways for ADCY1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/28         Kegg Pathways  (Kegg details for ADCY1) (see all 28):
        Purine metabolism
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Vascular smooth muscle contraction


    ADCY1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/300 Interacting proteins for ADCY1 (Q088283 ENSP000002973234) via UniProtKB, MINT, STRING, and/or I2D (see all 300)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2Q084623, ENSP000003429524I2D: score=1 STRING: ENSP00000342952
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): 5/23 biological process terms (GO ID links to tree view) (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process NAS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    ADCY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADCY1 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADCY1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADCY1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    10/12 HMDB Compounds for ADCY1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--

    2 DrugBank Compounds for ADCY1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetproduct of11752352 16895552 17229090
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    10/34 Novoseek inferred chemical compound relationships for ADCY1 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 71.5 18 8853375 (2), 8392469 (1), 17611668 (1), 7704910 (1) (see all 15)
    2',5'-dideoxyadenosine 69.6 7 7512387 (1), 17294519 (1), 7530840 (1)
    cyclic amp 66.6 10 11515719 (2), 1847586 (1), 15845377 (1), 16201743 (1) (see all 8)
    1,9-dideoxyforskolin 61.8 1 8853375 (1)
    dbc-amp 59.4 3 1829779 (1), 8625744 (1), 1372296 (1)
    ibmx 55.2 7 8853375 (2), 7704910 (1), 7530840 (1), 12372804 (1) (see all 5)
    isoproterenol 52.6 4 1711430 (2), 1702264 (1), 1981962 (1)
    adenylate 43.5 6 20496301 (1), 9763301 (1), 16297936 (1), 9176812 (1) (see all 5)
    theophylline 29.2 2 12359956 (1), 7704910 (1)
    salbutamol 26.8 1 1981962 (1)

    Search CenterWatch for drugs/clinical trials and news about ADCY1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADCY1 gene (2 alternative transcripts): 
    NM_001281768.1  NM_021116.2  

    Unigene Cluster for ADCY1:

    Adenylate cyclase 1 (brain)
    Hs.192215  [show with all ESTs]
    Unigene Representative Sequence: NM_021116
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432715(uc003tnd.3) ENST00000297323(uc003tne.4) ENST00000468353

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADCY1
    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY1 (see all 109):
    hsa-miR-124* hsa-miR-3130-5p hsa-miR-199a-3p hsa-miR-4272 hsa-miR-3653 hsa-miR-374a hsa-miR-4275 hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ADCY1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY1
    Clone
    Products:
         
    OriGene clones in human, mouse for ADCY1 (see all 7)
    OriGene ORF clones in mouse, rat for ADCY1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY1 (NM_021116)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY1
    Sirion Biotech Customized lentivirus for stable overexpression of ADCY1 
                         Customized lentivirus expression plasmids for stable overexpression of ADCY1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCY1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY1

    Additional mRNA sequence: 

    AB209496.1 AF086306.1 AF497515.1 AK024415.1 AK055343.1 AK095518.1 AK095665.1 BC036858.1 
    BC041473.1 L05500.1 

    4 DOTS entries:

    DT.115205  DT.453040  DT.100790903  DT.101975235 

    24/167 AceView cDNA sequences (see all 167):

    L05500 AL534368 AI858628 T33055 NM_021116 CB162512 AW058472 BM932315 
    AF086306 AA351841 CA334785 AA325723 CB161607 AK055343 AL706851 CR612961 
    AI858804 BX101242 W69791 BM695328 CA941103 AL120172 AI124894 W69879 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCY1 expression in normal human tissues (normalized intensities)      ADCY1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGATTTGT
    ADCY1 Expression
    About this image


    ADCY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/13 selected tissues (see all 13) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Thalamus
             Olfactory Bulb   
     
     Neural Tube (Nervous System)    fully expand to see all 4 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Horn   
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Peripheral Nervous System (Nervous System)
             spinal/ganglion/dorsal root ganglion   

    See ADCY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCY1

    SOURCE GeneReport for Unigene cluster: Hs.192215

    UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
    Tissue specificity: Brain, retina and adrenal medulla

        SABiosciences Expression via Pathway-Focused PCR Arrays including ADCY1: 
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ADCY1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCY1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADCY1 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy11 , 5 adenylate cyclase 11, 5 88.13(n)1
    92.67(a)1
      11 (4.72 cM)5
    4325301  NM_009622.11  NP_033752.11 
     70634895 
    chicken
    (Gallus gallus)
    Aves ADCY11 adenylate cyclase 1 (brain) 74.53(n)
    82.92(a)
      420788  XM_418883.3  XP_418883.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY16
    adenylate cyclase 1 (brain)
    76(a)
    1 ↔ 1
    6(53652888-53807636)
    zebrafish
    (Danio rerio)
    Actinopterygii adcy1a1 adenylate cyclase 1a 70.87(n)
    74.14(a)
      557026  NM_001168349.1  NP_001161821.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rut1 , 3 molting cycle (sensu Insecta) adenylate
    cyclase3
    rutabaga1
    41(a)3
    55.12(n)1
    46.71(a)1
      12F43
    324061  NM_078601.31  NP_511156.21 


    ENSEMBL Gene Tree for ADCY1 (if available)
    TreeFam Gene Tree for ADCY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCY1 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  GUCY2F2  ADCY82  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY62  GUCY1A32  ADCY42  NPR22  ADCY32  
    9 SIMAP similar genes for ADCY1 using alignment to 5 protein entries:     ADCY1_HUMAN (see all proteins):
    ADCY6    ADCY5    ADCY3    ADCY7    ADCY8    ADCY4
    ADCY2    NPR1    DKFZp686J099

    ADCY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3071 SNPs in ADCY1 are shown (see all 3071)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425265501,2
    --45612161(+) ACTTGA/GAAAGA 1 -- us2k10--------
    rs1875489121,2
    --45612229(+) AAGGTG/TCTTTC 1 -- us2k10--------
    rs1925481101,2
    C--45612279(+) GAGCCA/GGTGCT 1 -- us2k10--------
    rs1167622681,2
    C,F--45612350(+) CAGAGT/CGGTGG 1 -- us2k12Minor allele frequency- C:0.08WA EA 238
    rs787158811,2
    C,F--45612640(+) AAAAAC/TGGCAA 1 -- us2k12Minor allele frequency- T:0.08WA EA 238
    rs1379758271,2
    C--45612712(+) TTGTT-/CCCGTA 1 -- us2k10--------
    rs1824411801,2
    --45612772(+) TAAAAC/TAGACC 1 -- us2k10--------
    rs1441542411,2
    --45612892(+) CCATAC/TTGAGG 1 -- us2k10--------
    rs1879634081,2
    --45612933(+) GCAGGA/GGTTCT 1 -- us2k10--------
    rs1926434031,2
    --45612999(+) CACTGC/TAAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCY1 (45613739 - 45762715 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADCY1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv818498CNV Loss17921354
    esv24848CNV Loss19812545
    nsv523515CNV Loss19592680
    nsv888002CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADCY1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADCY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103072    OMIM disorders: --

    20/39 diseases for ADCY1 (see all 39):    About MalaCards
    mccune albright syndrome    adenoma    precocious puberty    thyroid adenoma
    syncope    chondroblastoma    pseudohypoparathyroidism    rheumatic fever
    chondrodysplasia    portal hypertension    cholera    differentiating neuroblastoma
    nicotine dependence    hyperthyroidism    trypanosomiasis    thyroiditis
    cushing's syndrome    chagas disease    autism spectrum disorder    neuroblastoma

    1 disease from the University of Copenhagen DISEASES database for ADCY1:
    Cholera

    ADCY1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for ADCY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 41.4 2 12736381 (1), 1661420 (1)
    thyroid carcinoma 14.8 1 7478621 (1)
    adenoma 3.42 1 11420487 (1)
    leukemia 0 1 2154651 (1)
    ischemia 0 1 16297936 (1)

    Genetic Association Database (GAD): ADCY1
    Human Genome Epidemiology (HuGE) Navigator: ADCY1 (3 documents)

    Export disorders for ADCY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCY1 gene, integrated from 9 sources (see all 153):
    (articles sorted by number of sources associating them with ADCY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase. (PubMed id 8314585)1, 2, 3 Villacres E.C....Storm D.R. (1993)
    2. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (2009)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
    4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (2009)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    7. CFTR-adenylyl cyclase I association responsible for U TP activation of CFTR in well-differentiated primary human bronchial cell cultu res. (PubMed id 20554763)1 Namkung W....Verkman A.S. (2010)
    8. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. (PubMed id 19029295)1 Masada N....Cooper D.M. (2009)
    9. Overexpression of type I adenylyl cyclase in the fore brain impairs spatial memory in aged but not young mice. (PubMed id 19726641)1 Garelick M.G....Storm D.R. (2009)
    10. Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. (PubMed id 17586501)1 Nlend M.C....Salathe M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 107 HGNC: 232 AceView: ADCY1 Ensembl:ENSG00000164742 euGenes: HUgn107
    ECgene: ADCY1 Kegg: 107 H-InvDB: ADCY1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADCY1 gene:
    Search GeneIP for patents involving ADCY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
     EMD Millipore small molecules (inhibitor) for ADCY1
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ADCY1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ADCY1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ADCY1  
     OriGene qSTAR qPCR primer pairs in human, mouse for ADCY1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ADCY1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADCY1   OriGene Custom Protein Services for ADCY1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADCY1
     QIAGEN SeqTarget long-range PCR primers for resequencing ADCY1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY1
     GenScript Custom Purified and Recombinant Proteins Services for ADCY1 GenScript cDNA clones with any tag delivered in your preferred vector for ADCY1
     GenScript Custom Assay Services for ADCY1 GenScript Custom Superior Antibodies Services for ADCY1
     GenScript Custom overexpressing Cell Line Services for ADCY1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADCY1 promoter
     Search Chromatin IP Primers for ADCY1
     RT2 qPCR Primer Assay in human, mouse, rat ADCY1
     Search GNC Networks for ADCY1
     SABiosciences PCR Arrays including human, mouse, rat ADCY1
     Tocris compounds for ADCY1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADCY1 antibodies
     ADCY1 lysates
     Antibodies for ADCY1
     See all of Abcam's Antibodies, Kits and Proteins for ADCY1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ADCY1
     Antibodies for ADCY1
     ELISAs for ADCY1
     CLIAs for ADCY1
     Search LifeMap BioReagents cell lines for ADCY1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY1
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ADCY1
     SwitchGear Promoter luciferase reporter plasmids for ADCY1
     ThermoFisher Antibodies for ADCY1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ADCY1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ADCY1
    Customized:
     lentivirus for stable overexpression of ADCY1
     lentivirus expression plasmids for stable overexpression of ADCY1
     adenovirus for overexpression of ADCY1
     LSBio Antibodies in human, mouse, rat for ADCY1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADCY1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4