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ADCY1 Gene

protein-coding GIFtS: 63

GC07P045580

adenylate cyclase 1 (brain)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
AC1 ^¹, ²
EC 4.6.1.1 ^³

Descriptions
3',5'-cyclic AMP synthetase ^²
ATP pyrophosphate-lyase ^²
ATP pyrophosphate-lyase 1 ^³
Adenylate cyclase type I ^², ³
Adenylyl cyclase 1 ^³
Ca(2+)/calmodulin-activated adenylyl cyclase ^², ³
adenyl cyclase ^²
adenylate cyclase 1 ^²
adenylate cyclase 1 (brain) ^²

External Ids
HGNC: 232¹
Entrez Gene: 107²
UniProtKB: Q08828³
Ensembl: ENSG00000164742⁷

Search outside databases for aliases for ADCY1 gene

Previous GC identifers: GC07P045296 GC07P045354 GC07P045387

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ADCY1:

This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is

involved in pattern formation of the brain. [provided by RefSeq]

UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828

Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes

in the central nervous system. It may play a role in memory acquisition and learning

Gene Wiki entry for ADCY1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ADCY1 gene

Entrez Gene cytogenetic band: 7p13-p12 Ensembl cytogenetic band: 7p13 HGNC cytogenetic band: 7p13-p12

ADCY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P045580: (about GC identifiers)

Start:	45,580,646 bp from pter
End:	45,729,237 bp from pter
Size:	148,592 bases
Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 45,653,342-45,802,043

RefSeq DNA sequence:

NC_000007.12 NT_007819.16 NT_079592.2

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828 (See protein sequence)

Recommended Name: Adenylate cyclase type 1

Size: 1119 amino acids; 123440 Da

Cofactor: Binds 2 magnesium ions per subunit (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: A4D2L8 Q75MI1

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_066939.1

ENSEMBL proteins:

ENSP00000297323

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Adenylate cyclase 1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	NAS	--

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Antibodies for ADCY1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Adenylate cyclase 1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for ADCY1

Assays for ADCY1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q08828

ProtoNet protein and cluster: Q08828

1 Blocks protein family: IPB009398 Adenylate cyclase-like

UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828

Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family

Similarity: Contains 2 guanylate cyclase domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADCY1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADCY1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021116

Applied Biosystems Silencer® siRNAs for ADCY1

Sigma-Aldrich siRNA and siRNA Panels for ADCY1

Sigma-Aldrich shRNA for ADCY1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_021116
Myc/DDK tagged cDNA clone in CMV expression vector: NM_021116
untagged cDNA clones in CMV expression vector (see all 3): BC036858

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_021116

UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828

Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes

in the central nervous system. It may play a role in memory acquisition and learning

Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate

Enzyme regulation: Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma

subunit complex

Enzyme Number (IUBMB): EC 4.6.1.1

Genatlas biochemistry entry for ADCY1:

adenylyl cyclase,type I,calmodulin sensitive,fetal brain

4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Adcy1):

behavior/neurological

homeostasis/metabolism

nervous system

touch/vibrissae

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	IEA	--
GO:0005516	calmodulin binding	NAS	--
GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity	NAS	8314585

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/23 Sigma-Aldrich "Your Favorite Gene" Pathways for ADCY1 (Your Favorite Gene powered by Ingenuity) (see all 23 )

Synaptic Long Term Potentiation
Purine Metabolism
Dopamine Receptor Signaling
Cardiac &beta
PPAR&alpha

GeneDecks ADCY1 for the pathways selected above

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5/108 Interacting proteins for ADCY1 (ENSP00000297323³) via UniProtKB, MINT, and/or STRING (see all 108 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CALM3	ENSP00000291295³	STRING (score=.972)
GNAI2	ENSP00000312999³	STRING (score=.972)
ADCY2	ENSP00000371971³	STRING (score=.965)
PRKAR2B	ENSP00000265717³	STRING (score=.954)
PDE1A	ENSP00000309269³	STRING (score=.953)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006171	cAMP biosynthetic process	NAS	--
GO:0007616	long-term memory	IEA	--
GO:0009755	hormone-mediated signaling	EXP	12626323

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ADCY1

Sigma-Aldrich Small Molecules for ADCY1:

Inhibitor

Compounds for ADCY1 available from Tocris Bioscience

Compound	Action	CAS number
SQ 22536	Adenylyl cyclase inhibitor	[17318-31-9]
NKH 477	Water-soluble adenylyl cyclase activator	[138605-00-2]
PACAP 1-38	Potent stimulator of adenylyl cyclase
Forskolin	Adenylyl cyclase activator	[66575-29-9]
PACAP 1-27	Potent stimulator of adenylyl cyclase	[137061-48-4]

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10/21 Novoseek chemical compound relationships for ADCY1 gene (see all 21 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
2',5'-dideoxyadenosine	70.33	7	7512387 (1), 17294519 (1), 7530840 (1)
forskolin	69.89	18	8853375 (2), 8392469 (1), 17611668 (1), 7704910 (1) (see all 15)
cyclic amp	66.46	9	11515719 (2), 1847586 (1), 15845377 (1), 16201743 (1) (see all 7)
1,9-dideoxyforskolin	62.58	1	8853375 (1)
dbc-amp	60.10	3	1829779 (1), 8625744 (1), 1372296 (1)
prostaglandin	20.41	4	8908618 (2), 15845377 (1)
progesterone	18.34	4	14567882 (1), 7530840 (1), 15131261 (1), 11596304 (1)
atp	17.24	4	12359956 (1), 9338086 (1), 18301971 (1)
adp	17.11	3	12149126 (1)
katp	16.81	1	11336627 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ADCY1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ADCY1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_021116

Sigma-Aldrich siRNA and siRNA Panels for ADCY1

Sigma-Aldrich shRNA for ADCY1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_021116

REFSEQ mRNAs for ADCY1 gene:

NM_021116.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_021116

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_021116
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_021116
                                 untagged cDNA clones in CMV expression vector (see all 3): BC036858

Additional cDNA sequence:

AB209496.1 AF086306.1 AF497515.1 AK024415.1 AK055343.1 AK095518.1 AK095665.1 BC036858.1

BC041473.1 CR596735.1 CR612961.1 L05500.1

4 DOTS entries:

DT.115205 DT.453040 DT.100790903 DT.101975235

24/167 AceView cDNA sequences (see all 167 ):

L05500 AA351841 AL120172 CB162512 BM695328 AV650659 D55782 AL534368

W69791 AA497018 CB156728 AF086306 BM926997 BM926775 BC041473 BX095677

BM479247 CR612961 AW058472 AA325723 AK055343 AI858628 BQ638576 CA334785

highest scoring ESTs for ADCY1:

L05500 R37248 R39984 AA020807 AA021121 AA046447 AA053983 AA082405 AA325723 AA351841

Unigene Cluster for ADCY1:

Adenylate cyclase 1 (brain)

Hs.192215 [show with all ESTs]

Unigene Representative Sequence: NM_021116

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000297323

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ADCY1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ADCY1

¹ / ² / ³

12 probe-sets matching ADCY1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33353_at²^{, 3}	U95-A	1	1.00	1.00	0.84	1.02	W26466	0.60	1.00	0.82	1
67169_at²^{, 3}	U95-E	1	1.00	1.00	0.21	1.45	R39984	1.00	1.00	1.00	1
61740_at²^{, 3}	U95-C	1	1.00	1.00	0.77	1.17	R37248	1.00	1.00	1.00	1
35580_at²^{, 3}	U95-A	2	1.00	0.94	0.55	0.42	L05500	1.00	1.00	1.00	1
213245_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AL120173	0.80	1.00	0.91	1
215348_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L05500	1.00	1.00	1.00	1
232062_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK024415	0.80	1.00	0.91	1
235049_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AA021120	0.60	1.00	0.82	1
213245_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215348_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232062_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
235049_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks ADCY1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: ATAGATTTGT

SOURCE GeneReport for Unigene cluster: Hs.192215
Expression variation in blood from EXPOLDB for ADCY1
UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
Tissue specificity: Brain, retina and adrenal medulla

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ADCY1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ADCY1¹	--	adenylate cyclase 1 (brain)	97.77(n) 97.59(a)	463392 XM_519081.2 XP_519081.2
cow (Bos taurus)	ADCY1¹	--	adenylate cyclase 1 (brain)	88.68(n) 92.94(a)	281601 NM_174229.2 NP_776654.1
rat (Rattus norvegicus)	Adcy1¹	--	adenylate cyclase 1 (brain)	87.6(n) 92.31(a)	305509 XM_223616.4 XP_223616.4
mouse (Mus musculus)	Adcy1^{1, 5}	11 (1.25 cM)⁵	adenylate cyclase 1^{1, 5}	88.13(n)¹ 92.67(a)¹	432530¹ NM_009622.1¹ NP_033752.1¹ AF053979⁵ AF053980⁵ (see all 20)
chicken (Gallus gallus)	ADCY1¹	--	adenylate cyclase 1 (brain)	74.53(n) 82.92(a)	420788 XM_418883.2 XP_418883.2

About this table Species with no ortholog for ADCY1

ENSEMBL Gene Tree for ADCY1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ADCY1 gene

ADCY5² ADCY8² ADCY6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/696 NCBI SNPs in ADCY1 are shown (see all 696 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 195)

AB	SNP ID	Valid	Chr 7 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2461127^1,2	A,C,F,H,O	45724331(-)	`TGGAAC/TGGATC`	1	--	ut3¹		7	NA EU EA WA	560
	rs12754^1,2	A,C,F,H,O	45727719(+)	`GGTTGT/GATTTG`	1	--	ut3¹		13	MN NA EU EA WA	1292
	rs2280496^1,2	A,C,F,H,O	45723522(-)	`AAAAGG/CAAGTT`	1	--	ut3¹ trp³		12	EA EU WA NA	2396
	rs7806607^1,2	A,C,F,H	45726813(+)	`TCTATT/GAATAC`	1	--	ut3¹ ese³		4	EU EA WA	416
	rs2471267^1,2	A,C,F,H	45725787(-)	`CACACG/AACAGA`	1	--	ut3¹ ese³		8	EU EA WA	834
	rs3735666^1,2	C,F,H	45728477(+)	`TGCACA/CAAGGG`	1	--	ut3¹ ese³		8	EA EU WA NA	2052
--	rs1128602^1,2	C,F,H	45729221(+)	`AAAGGG/AAAAAA`	1	--	ut3¹		6	EU EA NA	390
	rs2280495^1,2	C,F,O	45723868(-)	`CCACCC/TGGGCC`	1	--	ut3¹ ese³		5	EA NA	1710
	rs10225980^1,2	C,F,H	45724372(+)	`GACCAA/GCGGTG`	1	--	ut3¹ ese³		11	EU EA WA NA	982
	rs3735669^1,2	C,F,H	45721107(-)	`ATCTTC/TCATCA`	1	--	ut3¹		12	EU EA WA	1258

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HapMap Linkage Disequilibrium images for ADCY1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 103072

5 Novoseek disease relationships for ADCY1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
cholera	42.60	2	12736381 (1), 1661420 (1)
thyroid carcinoma	16.65	1	7478621 (1)
adenoma	5.14	1	11420487 (1)
leukemia	0.00	1	2154651 (1)
ischemia	0.00	1	16297936 (1)

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Human Genome Epidemiology Navigator: ADCY1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/133 PubMed articles for ADCY1 gene (see all 133 ):

Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase. (PubMed id 8314585)^{2, 3, 4} Villacres E.C....Storm D.R. (1993)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{3, 4} Hillier L.W.... Wilson R.K. (2003)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{3, 4} Scherer S.W....Tsui L.C. (2003)
Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. (PubMed id 19029295)³ Masada N....Cooper D.M. (2009)
A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)³ de Krom M....van Ree J.M. (2009)
Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)³ Need A.C....Goldstein D.B. (2009)
Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. (PubMed id 17586501)³ Nlend M.C....Salathe M. (2007)
Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase. (PubMed id 16531006)³ Weber B....H Tonner P. (2006)
Using molecular tools to dissect the role of Galphas in sensitization of AC1. (PubMed id 15361543)³ Vortherms T.A....Watts V.J. (2004)
Overexpression of type-1 adenylyl cyclase in mouse forebrain enhances recognition memory and LTP. (PubMed id 15133516)³ Wang H....Storm D.R. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 107	HGNC: 232	AceView: ADCY1	Ensembl:ENSG00000164742	euGenes: HUgn107
ECgene: ADCY1	H-InvDB: ADCY1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for ADCY1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ADCY1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ADCY1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ADCY1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ADCY1		Small molecules for ADCY1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Antibodies (Adenylate cyclase 1)

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Tocris compounds for ADCY1

	Drugs for ADCY1
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for ADCY1

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ADCY1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ADCY1

Summaries
for ADCY1

Genomic Location
for ADCY1

Proteins
for ADCY1

Protein Domains/
Families
for ADCY1

Gene Function
for ADCY1

Pathways & Interactions
for ADCY1

Drugs & Compounds
for ADCY1

Transcripts
for ADCY1

Expression
for ADCY1

Orthologs
for ADCY1

Paralogs
for ADCY1

SNPs/Variants
for ADCY1

Disorders & Mutations
for ADCY1

Medical News
for ADCY1

Publications
for ADCY1

Search for ADCY1

Genome Databases showing ADCY1

Other Databases showing ADCY1

Specialized Databases showing ADCY1

Licensable Technologies
for ADCY1

Services
for ADCY1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ADCY1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ADCY1

Summariesfor ADCY1

Genomic Locationfor ADCY1

Proteinsfor ADCY1

Protein Domains/Familiesfor ADCY1

Gene Functionfor ADCY1

Pathways & Interactionsfor ADCY1

Drugs & Compoundsfor ADCY1

Transcriptsfor ADCY1

Expression for ADCY1

Orthologsfor ADCY1

Paralogsfor ADCY1

SNPs/Variantsfor ADCY1

Disorders & Mutationsfor ADCY1

Medical Newsfor ADCY1

Publicationsfor ADCY1

Search for ADCY1

Genome Databases showing ADCY1

Other Databases showing ADCY1

Specialized Databases showing ADCY1

Licensable Technologiesfor ADCY1

Servicesfor ADCY1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ADCY1

Summaries
for ADCY1

Genomic Location
for ADCY1

Proteins
for ADCY1

Protein Domains/
Families
for ADCY1

Gene Function
for ADCY1

Pathways & Interactions
for ADCY1

Drugs & Compounds
for ADCY1

Transcripts
for ADCY1

Expression
for ADCY1

Orthologs
for ADCY1

Paralogs
for ADCY1

SNPs/Variants
for ADCY1

Disorders & Mutations
for ADCY1

Medical News
for ADCY1

Publications
for ADCY1

Licensable Technologies
for ADCY1

Services
for ADCY1