ADCY1 Gene
protein-coding GIFtS: 62
GCID: GC07P045580
|
|
adenylate cyclase 1 (brain)
| |
Aliases
for ADCY1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenylate Cyclase 1 (Brain)1 2 | | Ca(2+)/Calmodulin-Activated Adenylyl Cyclase2 3 | | AC11 2 | | EC 4.6.1.13 8 | | Adenylate Cyclase Type I2 3 | | 3',5'-Cyclic AMP Synthetase2 | | Adenylyl Cyclase 12 3 | | Adenyl Cyclase2 | | ATP Pyrophosphate-Lyase 12 3 | | Adenylate Cyclase Type 12 |
Export aliases for ADCY1 gene to outside databasesPrevious GC identifers: GC07P045296 GC07P045354 GC07P045387 |
Summaries
for ADCY1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ADCY1:
This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in patternformation of the brain. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the centralnervous system. It may play a role in memory acquisition and learning
 summary
for ADCY1: Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.
Gene Wiki entry for ADCY1
|
Genomic Views
for ADCY1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADCY1 gene promoter:
GR FOXF2 NF-AT CREB FAC1 NF-AT2 deltaCREB Chx10 GR-alpha NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADCY1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7p13-p12 Ensembl cytogenetic band: 7p12.3 HGNC cytogenetic band: 7p13-p12ADCY1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P045580: view genomic region
(about GC identifiers)
Start:
|
45,613,739 bp from pter |
End:
|
45,762,715 bp from pter |
Size:
|
148,977 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 45,653,346-45,802,046 |
|
Proteins
for ADCY1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828 (See
protein sequence)Recommended Name: Adenylate cyclase type 1 Size: 1119 amino acids; 123440 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A4D2L8 Q75MI1Explore the universe of human proteins at neXtProt for ADCY1: NX_Q08828
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q08828
4/14 DME Specific Peptides for ADCY1 (Q08828) (see all 14)
ADCY1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_066939.1
ENSEMBL proteins: ENSP00000392721 ENSP00000297323 Reactome Protein details: Q08828
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ADCY1 for ontologies About GeneDecksing
ADCY1 Antibody Products:
Assay Products for ADCY1: |
Protein
Domains /
Families
for ADCY1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADCY1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q08828ProtoNet protein and cluster: Q08828 1 Blocks protein family: IPB009398 Adenylate cyclase-like
UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase familySimilarity: Contains 2 guanylate cyclase domains |
Function
for ADCY1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the centralnervous system. It may play a role in memory acquisition and learningCatalytic activity: ATP = 3',5'-cyclic AMP + diphosphateEnzyme regulation: Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex Genatlas biochemistry entry for ADCY1:adenylyl cyclase,type I,calmodulin sensitive,fetal brain
Enzyme Number (IUBMB): EC 4.6.1.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADCY1 (NM_021116) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCY1 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
ADCY1 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for ADCY1: Adcy1tm1.1Ito Adcy1tm1Drs
4 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Adcy1):
ADCY1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ADCY1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/74 super-pathways (see all 74) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Signaling by FGFR | | | 2 | PKA activation in glucagon signalling | | | 3 | DAG and IP3 signaling | | | 4 | G-protein signaling_G-Protein alpha-i signaling cascades | | | 5 | Regulation of Water Balance by Renal Aquaporins | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/21 EMD Millipore Pathways for ADCY1 (see all 21)
5/44 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY1 (see all 44)
5/24  GeneGo (Thomson Reuters) Pathways for ADCY1 (see all 24)
5/7  BioSystems Pathways for ADCY1 (see all 7)
5/53 
Reactome Pathways for ADCY1 (see all 53)
3  PharmGKB Pathways for ADCY1
5/19 
Kegg Pathways (Kegg details for ADCY1) (see all 19):
ADCY1 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/300 Interacting proteins for ADCY1 (Q088283 ENSP000002973234) via UniProtKB, MINT, STRING, and/or I2D (see all 300)About this table
Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006112 | energy reserve metabolic process |
TAS | -- | | GO:0006171 | cAMP biosynthetic process |
NAS | -- | | GO:0006833 | water transport |
TAS | -- | | GO:0007165 | signal transduction |
TAS | -- | | GO:0007173 | epidermal growth factor receptor signaling pathway |
TAS | -- |
ADCY1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADCY1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ADCY1 for compounds About GeneDecksing
Compounds for ADCY1 available from Tocris Bioscience About this table
| Compound | Action |
CAS
# |
|---|
| BPIPP | Non-competitive GC inhibitor. Also AC inhibitor | [325746-94-9] | | NKH 477 | Water-soluble adenylyl cyclase activator | [138605-00-2] | | Forskolin | Adenylyl cyclase activator | [66575-29-9] | | SQ 22536 | Adenylyl cyclase inhibitor | [17318-31-9] | | PACAP 1-38 | Potent stimulator of adenylyl cyclase | -- |
10/12 HMDB Compounds for ADCY1 (see all 12) About this table
2 DrugBank Compounds for ADCY1 About this table
10/34 Novoseek chemical compound relationships for ADCY1 gene (see all 34) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| forskolin |
71.5 |
18 |
8853375 (2), 8392469 (1), 17611668 (1), 7704910 (1) (see all 15) |
| 2',5'-dideoxyadenosine |
69.6 |
7 |
7512387 (1), 17294519 (1), 7530840 (1) |
| cyclic amp |
66.6 |
10 |
11515719 (2), 1847586 (1), 15845377 (1), 16201743 (1) (see all 8) |
| 1,9-dideoxyforskolin |
61.8 |
1 |
8853375 (1) |
| dbc-amp |
59.4 |
3 |
1829779 (1), 8625744 (1), 1372296 (1) |
| ibmx |
55.2 |
7 |
8853375 (2), 7704910 (1), 7530840 (1), 12372804 (1) (see all 5) |
| isoproterenol |
52.6 |
4 |
1711430 (2), 1702264 (1), 1981962 (1) |
| adenylate |
43.5 |
6 |
20496301 (1), 9763301 (1), 16297936 (1), 9176812 (1) (see all 5) |
| theophylline |
29.2 |
2 |
12359956 (1), 7704910 (1) |
| salbutamol |
26.8 |
1 |
1981962 (1) |
Search CenterWatch for drugs/clinical trials and news about ADCY1
|
Transcripts
for ADCY1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADCY1 gene: NM_021116.2 Unigene Cluster for ADCY1: Adenylate cyclase 1 (brain) Hs.192215 [show with all ESTs]Unigene Representative Sequence: NM_0211163 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000432715(uc003tnd.3) ENST00000297323(uc003tne.4) ENST00000468353
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADCY1 (NM_021116) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCY1 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY1 |
Additional cDNA sequence: AB209496.1 AF086306.1 AF497515.1 AK024415.1 AK055343.1 AK095518.1 AK095665.1 BC036858.1 BC041473.1 L05500.1 4 DOTS entries: DT.115205 DT.453040 DT.100790903 DT.101975235 24/167 AceView cDNA sequences (see all 167): AL534368 BX101242 AK055343 AI858804 AL706851 CR612961 CA334785 AA325723 CB161607 AF086306 AA351841 BM932315 AW058472 CB162512 NM_021116 T33055 AI858628 L05500 AA497018 BC041473 BQ638576 BM926997 BM926775 BX095677
GeneLoc Exon Structure
|
Expression
for ADCY1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADCY1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAGATTTGT
About this image
See ADCY1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCY1
SOURCE GeneReport for Unigene cluster: Hs.192215
UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828Tissue specificity: Brain, retina and adrenal medulla
SABiosciences Expression via Pathway-Focused PCR Arrays including ADCY1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCY1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY1 |
Orthologs
for ADCY1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ADCY1 gene from 5/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ADCY11 |
adenylate cyclase 1 (brain) |
74.53(n)
82.92(a) |
|
420788 XM_418883.3 XP_418883.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ADCY16 |
-- |
78(a) |
1 ↔ 1 |
6(53653162-53807636) |
zebrafish
(Danio rerio) |
Actinopterygii |
adcy1a1 |
adenylate cyclase 1a |
70.87(n)
74.14(a) |
|
557026 NM_001168349.1 NP_001161821.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
rut1 , 3 |
molting cycle (sensu Insecta) adenylate
cyclase3
rutabaga1 |
41(a)3
55.12(n)1
46.71(a)1 |
|
12F43
324061 NM_078601.31 NP_511156.21 |
worm
(Caenorhabditis elegans) |
Secernentea |
acy-43 |
-- |
51(a) |
|
V(5627531-5629064) -- |
ENSEMBL Gene Tree for ADCY1 (if available)
TreeFam Gene Tree for ADCY1 (if available) |
Paralogs
for ADCY1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADCY1 gene
- ADCY52 ADCY22 GUCY2D2 GUCY2C2 NPR12 ADCY82 GUCY2F2 GUCY1A22
- ADCY72 ADCY92 GUCY1B32 ADCY62 GUCY1A32 ADCY42 NPR22 ADCY32
9 SIMAP similar genes for ADCY1 using alignment to 5 protein entries: ADCY1_HUMAN (see all proteins):ADCY6 ADCY5 ADCY3 ADCY8 ADCY7 ADCY4
ADCY2 NPR1 DKFZp686J099
ADCY1 for paralogs About GeneDecksing
|
Genomic Variants
for ADCY1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADCY1 (45613739 - 45762715 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ADCY1
1 CNV: 10185
1 Indel: 69872 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCY1 |
|
Disorders
/ Diseases
for ADCY1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADCY1 for disorders About GeneDecksing
OMIM gene information: 103072
OMIM disorders: --
20/43  diseases for ADCY1 (see all 43): About MalaCardsprecocious puberty thyroid adenoma chondrodysplasia adenoma
thyroiditis mccune albright syndrome type 2 diabetes mellitus autism spectrum disorder
nicotine dependence differentiating neuroblastoma portal hypertension rheumatic fever
diabetes mellitus pseudohypoparathyroidism chondroblastoma neuronitis
insulin resistance cushing's syndrome syncope cholera
1 disease from the University of Copenhagen DISEASES database for ADCY1:Cholera 5 Novoseek disease relationships for ADCY1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cholera |
41.4 |
2 |
12736381 (1), 1661420 (1) |
| thyroid carcinoma |
14.8 |
1 |
7478621 (1) |
| adenoma |
3.42 |
1 |
11420487 (1) |
| leukemia |
0 |
1 |
2154651 (1) |
| ischemia |
0 |
1 |
16297936 (1) |
Human Genome Epidemiology (HuGE) Navigator: ADCY1 (3 documents)
Export disorders for ADCY1 gene to outside databases
|
Publications
for ADCY1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADCY1 gene, integrated from 9 sources (see all 153):
(articles sorted by number of sources associating them with ADCY1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase. (PubMed id 8314585)1, 2, 3 Villacres E.C....Storm D.R. (1993)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
- CFTR-adenylyl cyclase I association responsible for U TP activation of CFTR in well-differentiated primary human bronchial cell cultu res. (PubMed id 20554763)1 Namkung W....Verkman A.S. (2010)
- Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. (PubMed id 19029295)1 Masada N....Cooper D.M. (2009)
- Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1 Wheeler H.E....Kim S.K. (2009)
- A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1 de Krom M....van Ree J.M. (2009)
- Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1 Need A.C....Goldstein D.B. (2009)
- Overexpression of type I adenylyl cyclase in the fore brain impairs spatial memory in aged but not young mice. (PubMed id 19726641)1 Garelick M.G....Storm D.R. (2009)
- Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. (PubMed id 17586501)1 Nlend M.C....Salathe M. (2007)
|
External Searches for ADCY1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADCY1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing ADCY1 gene
(According to HUGE)
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Specialized Databases showing ADCY1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ADCY1 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for ADCY1 gene:
Search GeneIP for patents involving ADCY1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ADCY1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCY1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCY1 | | | OriGene Protein Over-expression Lysate for ADCY1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADCY1 | | OriGene 3'-UTR Clone for ADCY1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCY1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADCY1 | | OriGene Custom Protein Services for ADCY1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADCY1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCY1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCY1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCY1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCY1 |
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| | | | Tocris compounds for ADCY1 |
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 | | | ADCY1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY1 |
|  |  |  | | | | Search ThermoFisher Antibodies for ADCY1 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY1 |
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