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ADCY1 Gene

protein-coding   GIFtS: 67
GCID: GC07P045580

Adenylate Cyclase 1 (Brain)

  See ADCY1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenylate Cyclase 1 (Brain)1 2     EC 4.6.1.13 8
Adenylate Cyclase Type I2 3     3',5'-Cyclic AMP Synthetase2
Adenylyl Cyclase 12 3     AC12
ATP Pyrophosphate-Lyase 12 3     Adenyl Cyclase2
Ca(2+)/Calmodulin-Activated Adenylyl Cyclase2 3     Adenylate Cyclase Type 12

External Ids:    HGNC: 2321   Entrez Gene: 1072   Ensembl: ENSG000001647427   OMIM: 1030725   UniProtKB: Q088283   

Export aliases for ADCY1 gene to outside databases

Previous GC identifers: GC07P045296 GC07P045354 GC07P045387


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADCY1 Gene:
This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This
protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate
splicing results in multiple transcript variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for ADCY1 Gene:
ADCY1 (adenylate cyclase 1 (brain)) is a protein-coding gene. Diseases associated with ADCY1 include deafness, autosomal recessive 44, and adenoma. GO annotations related to this gene include calcium- and calmodulin-responsive adenylate cyclase activity and calmodulin binding. An important paralog of this gene is ADCY5.

UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central
nervous system. It may play a role in memory acquisition and learning

summary for ADCY1 Gene:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NT_007819.18  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADCY1 gene promoter:
         GR   FOXF2   NF-AT   CREB   FAC1   NF-AT2   deltaCREB   Chx10   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): ADCY1 promoter sequence
   Search Chromatin IP Primers for ADCY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADCY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p13-p12

ADCY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P045580:  view genomic region     (about GC identifiers)

Start:
45,613,739 bp from pter      End:
45,762,715 bp from pter
Size:
148,977 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 45,653,346-45,802,046     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828 (See protein sequence)
Recommended Name: Adenylate cyclase type 1  
Size: 1119 amino acids; 123440 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Secondary accessions: A4D2L8 Q75MI1

Explore the universe of human proteins at neXtProt for ADCY1: NX_Q08828

Explore proteomics data for ADCY1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn704
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADCY1 (Q08828) (see all 14)
     WQYDVWS  ADIVGFT  FHKIYIQ  TVNVASR 


    See ADCY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001268697.1  NP_066939.1  

    ENSEMBL proteins: 
     ENSP00000392721   ENSP00000297323  
    Reactome Protein details: Q08828

    ADCY1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for ADCY1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ADCY1
    GenScript Custom Purified and Recombinant Proteins Services for ADCY1
    Novus Biologicals ADCY1 Protein
    Novus Biologicals ADCY1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ADCY1

     
    Search eBioscience for Proteins for ADCY1 

     
    antibodies-online proteins for ADCY1 (3 products) 

     
    antibodies-online peptides for ADCY1

    ADCY1 Antibody Products:

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    Abcam antibodies for ADCY1
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    ThermoFisher Antibodies for ADCY1
    antibodies-online antibodies for ADCY1 (46 products) 

    ADCY1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ADCY1
    Cloud-Clone Corp. CLIAs for ADCY1
    Search eBioscience for ELISAs for ADCY1 
    antibodies-online kits for ADCY1 (27 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ADCY: Adenylate cyclases

    IUPHAR Guide to PHARMACOLOGY protein family classification: AC1
    Adenylyl cyclases

    2 InterPro protein domains:
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q08828

    ProtoNet protein and cluster: Q08828

    1 Blocks protein domain: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    Find genes that share domains with ADCY1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCY1_HUMAN, Q08828
    Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central
    nervous system. It may play a role in memory acquisition and learning
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex

         Genatlas biochemistry entry for ADCY1:
    adenylyl cyclase,type I,calmodulin sensitive,fetal brain

         Enzyme Number (IUBMB): EC 4.6.1.11 2

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity ----
    GO:0005516calmodulin binding IEA--
    GO:0005524ATP binding IEA--
    GO:0008294calcium- and calmodulin-responsive adenylate cyclase activity NAS8314585
         
    Find genes that share ontologies with ADCY1           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adcy1):
     behavior/neurological  homeostasis/metabolism  integument  nervous system 

    Find genes that share phenotypes with ADCY1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ADCY1: Adcy1tm1.1Ito Adcy1tm1Drs

       genOway: Develop your customized and physiologically relevant rodent model for ADCY1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ADCY1:
    hsa-let-7b-5p (MIRT052078), hsa-mir-331-3p (MIRT043290), hsa-mir-423-3p (MIRT042602), hsa-mir-320a (MIRT044544)

    Block miRNA regulation of human, mouse, rat ADCY1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADCY1 (see all 109):
    hsa-miR-124* hsa-miR-3130-5p hsa-miR-199a-3p hsa-miR-4272 hsa-miR-3653 hsa-miR-374a hsa-miR-4275 hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADCY1

    Gene Editing
    Products:
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    Clone
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    OriGene ORF clones in mouse, rat for ADCY1
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    GenScript: all cDNA clones in your preferred vector: ADCY1 (NM_021116)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADCY1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ADCY1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ADCY1
    Browse ESI BIO Cell Lines and PureStem Progenitors for ADCY1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADCY1_HUMAN, Q08828: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    cytosol1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ADCY1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADCY1 About   (see all 77)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Ca-dependent events
    DAG and IP3 signaling0.94
    Opioid Signalling0.54
    EGFR interacts with phospholipase C-gamma0.94
    Beta 2 adrenergic dependent CFTR expression0.50
    PLC-gamma1 signalling0.94
    Neurophysiological process PGE2 induced pain processing0.38
    CaM pathway0.93
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.33
    2Adenylate cyclase inhibitory pathway
    Adenylate cyclase inhibitory pathway0.53
    Inhibition of adenylate cyclase pathway0.00
    LPA4-mediated signaling events0.53
    Adenylate cyclase activating pathway0.00
    3Development Endothelin 1 EDNRA signaling
    Development Endothelin 1 EDNRA signaling0.41
    Inflammatory mediator regulation of TRP channels0.37
    GnRH signaling pathway0.38
    Estrogen signaling pathway0.34
    4Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins0.85
    Glucagon signaling in metabolic regulation0.70
    Aquaporin-mediated transport0.85
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40
    5Post NMDA receptor activation events
    Post NMDA receptor activation events0.90
    Long-term potentiation0.35
    Activation of NMDA receptor upon glutamate binding and postsynaptic events0.90


    Find genes that share SuperPaths with ADCY1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ADCY1 (see all 44)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    PACAP Signaling
    P2Y Receptor Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ADCY1 (see all 24)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Transcription PPAR Pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    G-protein signaling G-Protein alpha-i signaling cascades

    Selected BioSystems Pathways for ADCY1 (see all 7)
        Myometrial Relaxation and Contraction Pathways
    Hypothetical Network for Drug Addiction
    G Protein Signaling Pathways
    Calcium Regulation in the Cardiac Cell
    LPA receptor mediated events

    Selected Reactome Pathways for ADCY1 (see all 10)
        PKA activation
    CREB phosphorylation through the activation of Adenylate Cyclase
    PKA activation in glucagon signalling
    G alpha (z) signalling events
    Adenylate cyclase inhibitory pathway

    3 PharmGKB Pathways for ADCY1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ADCY1) (see all 32):
        Purine metabolism
    Rap1 signaling pathway
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADCY1: 
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ADCY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ADCY1 (Q088283 ENSP000002973234) via UniProtKB, MINT, STRING, and/or I2D (see all 310)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2Q084623, ENSP000003429524I2D: score=1 STRING: ENSP00000342952
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process ----
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--

    Find genes that share ontologies with ADCY1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ADCY1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    MDL 12330A hydrochlorideAdenylyl cyclase inhibitor; also cyclic nucleotide PDE inhibitor[40297-09-4]
    KH 7Selective soluble adenylyl cyclase inhibitor[330676-02-3]
    PACAP 1-27Potent stimulator of adenylyl cyclase[127317-03-7]

    Selected HMDB Compounds for ADCY1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--

    2 DrugBank Compounds for ADCY1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetproduct of11752352 16895552 17229090
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    Selected Novoseek inferred chemical compound relationships for ADCY1 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 71.5 18 8853375 (2), 8392469 (1), 17611668 (1), 7704910 (1) (see all 15)
    2',5'-dideoxyadenosine 69.6 7 7512387 (1), 17294519 (1), 7530840 (1)
    cyclic amp 66.6 10 11515719 (2), 1847586 (1), 15845377 (1), 16201743 (1) (see all 8)
    1,9-dideoxyforskolin 61.8 1 8853375 (1)
    dbc-amp 59.4 3 1829779 (1), 8625744 (1), 1372296 (1)
    ibmx 55.2 7 8853375 (2), 7704910 (1), 7530840 (1), 12372804 (1) (see all 5)
    isoproterenol 52.6 4 1711430 (2), 1702264 (1), 1981962 (1)
    adenylate 43.5 6 20496301 (1), 9763301 (1), 16297936 (1), 9176812 (1) (see all 5)
    theophylline 29.2 2 12359956 (1), 7704910 (1)
    salbutamol 26.8 1 1981962 (1)



    Find genes that share compounds with ADCY1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADCY1 gene (2 alternative transcripts): 
    NM_001281768.1  NM_021116.2  

    Unigene Cluster for ADCY1:

    Adenylate cyclase 1 (brain)
    Hs.192215  [show with all ESTs]
    Unigene Representative Sequence: NM_021116
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432715(uc003tnd.3) ENST00000297323(uc003tne.4) ENST00000468353

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADCY1 (see all 109):
    hsa-miR-124* hsa-miR-3130-5p hsa-miR-199a-3p hsa-miR-4272 hsa-miR-3653 hsa-miR-374a hsa-miR-4275 hsa-miR-149
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for ADCY1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ADCY1 (NM_021116)
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      QuantiFast Probe-based Assays in human, mouse, rat ADCY1

    Additional mRNA sequence: 

    AB209496.1 AF086306.1 AF497515.1 AK024415.1 AK055343.1 AK095518.1 AK095665.1 BC036858.1 
    BC041473.1 L05500.1 

    4 DOTS entries:

    DT.115205  DT.453040  DT.100790903  DT.101975235 

    Selected AceView cDNA sequences (see all 167):

    L05500 AL534368 AI858628 T33055 NM_021116 CB162512 AW058472 BM932315 
    AF086306 AA351841 CA334785 AA325723 CB161607 AK055343 AL706851 CR612961 
    AI858804 BX101242 W69791 BM695328 CA941103 AL120172 AI124894 W69879 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ADCY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATAGATTTGT
    ADCY1 Expression
    About this image


    ADCY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Midbrain tegmentum
     
     Kidney (Urinary System)
             Metanephros
    ADCY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADCY1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.192215

    UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
    Tissue specificity: Brain, retina and adrenal medulla

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ADCY1: 
              Gap Junctions in human mouse rat
              Synaptic Plasticity in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADCY1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adcy11 , 5 adenylate cyclase 11, 5 88(n)1
    92.62(a)1
      11 (4.72 cM)5
    4325301  NM_009622.11  NP_033752.11 
     70634895 
    chicken
    (Gallus gallus)
    Aves ADCY11 adenylate cyclase 1 (brain) 74.68(n)
    82.82(a)
      420788  XM_418883.4  XP_418883.4 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY16
    adenylate cyclase 1 (brain)
    76(a)
    1 ↔ 1
    6(53652888-53807636)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adcy11 adenylate cyclase 1 (brain) 71.62(n)
    80.59(a)
      100492373  XM_002933415.2  XP_002933461.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adcy1a1 adenylate cyclase 1a 70.87(n)
    74.14(a)
      557026  NM_001168349.1  NP_001161821.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rut1 , 3 molting cycle (sensu Insecta) adenylate
    cyclase3
    rutabaga1
    41(a)3
    56.88(n)1
    50.46(a)1
      12F43
    324061  NM_078601.31  NP_511156.21 


    ENSEMBL Gene Tree for ADCY1 (if available)
    TreeFam Gene Tree for ADCY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADCY1 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY62  GUCY1A32  ADCY42  NPR22  ADCY32  
    9 SIMAP similar genes for ADCY1 using alignment to 5 protein entries:     ADCY1_HUMAN (see all proteins):
    ADCY6    ADCY5    ADCY8    ADCY3    ADCY7    ADCY4
    ADCY2    NPR1    DKFZp686J099

    Find genes that share paralogs with ADCY1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADCY1 (see all 3071)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425265501,2
    --45612161(+) ACTTGA/GAAAGA 1 -- us2k10--------
    rs1875489121,2
    --45612229(+) AAGGTG/TCTTTC 1 -- us2k10--------
    rs1925481101,2
    C--45612279(+) GAGCCA/GGTGCT 1 -- us2k10--------
    rs1167622681,2
    C,F--45612350(+) CAGAGT/CGGTGG 1 -- us2k12Minor allele frequency- C:0.08WA EA 238
    rs787158811,2
    C,F--45612640(+) AAAAAC/TGGCAA 1 -- us2k12Minor allele frequency- T:0.08WA EA 238
    rs1379758271,2
    C--45612712(+) TTGTT-/CCCGTA 1 -- us2k10--------
    rs1824411801,2
    --45612772(+) TAAAAC/TAGACC 1 -- us2k10--------
    rs1441542411,2
    --45612892(+) CCATAC/TTGAGG 1 -- us2k10--------
    rs1879634081,2
    --45612933(+) GCAGGA/GGTTCT 1 -- us2k10--------
    rs1926434031,2
    --45612999(+) CACTGC/TAAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCY1 (45613739 - 45762715 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ADCY1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv818498CNV Loss17921354
    esv24848CNV Loss19812545
    nsv523515CNV Loss19592680
    nsv888002CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 103072    OMIM disorders: --

    3 diseases for ADCY1:    
    About MalaCards
    deafness, autosomal recessive 44    adenoma    deafness, autosomal recessive 76

    1 disease from the University of Copenhagen DISEASES database for ADCY1:
    Cholera

    Find genes that share disorders with ADCY1           About GenesLikeMe

    5 Novoseek inferred disease relationships for ADCY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 41.4 2 12736381 (1), 1661420 (1)
    thyroid carcinoma 14.8 1 7478621 (1)
    adenoma 3.42 1 11420487 (1)
    leukemia 0 1 2154651 (1)
    ischemia 0 1 16297936 (1)

    Genetic Association Database (GAD): ADCY1
    Human Genome Epidemiology (HuGE) Navigator: ADCY1 (3 documents)

    Export disorders for ADCY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADCY1 gene, integrated from 10 sources (see all 156):
    (articles sorted by number of sources associating them with ADCY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase. (PubMed id 8314585)1, 2, 3 Villacres E.C....Storm D.R. (Genomics 1993)
    2. Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. (PubMed id 19834535)1, 4 Wheeler H.E....Kim S.K. (PLoS Genet. 2009)
    3. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
    4. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1, 4 Need A.C....Goldstein D.B. (Eur. J. Hum. Genet. 2009)
    5. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    6. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (Science 2003)
    7. Differential effects of AGS3 expression on D(2L) dopamine receptor-mediated adenylyl cyclase signaling. (PubMed id 23504261)1 Conley J.M. and Watts V.J. (Cell. Mol. Neurobiol. 2013)
    8. CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures. (PubMed id 20554763)1 Namkung W....Verkman A.S. (Mol. Biol. Cell 2010)
    9. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. (PubMed id 19029295)1 Masada N....Cooper D.M. (J. Biol. Chem. 2009)
    10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 107 HGNC: 232 AceView: ADCY1 Ensembl:ENSG00000164742 euGenes: HUgn107
    ECgene: ADCY1 Kegg: 107 H-InvDB: ADCY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADCY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADCY1 gene:
    Search GeneIP for patents involving ADCY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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