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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCY1 Gene

protein-coding   GIFtS: 62
GCID: GC07P045580

adenylate cyclase 1 (brain)

 Explore 43 diseases affiliated with
ADCY1 via our new
 Human Malady Compendium 
Biological research products
for ADCY1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Adenylate Cyclase 1 (Brain)1 2     Ca(2+)/Calmodulin-Activated Adenylyl Cyclase2 3
AC11 2     EC 4.6.1.13 8
Adenylate Cyclase Type I2 3     3',5'-Cyclic AMP Synthetase2
Adenylyl Cyclase 12 3     Adenyl Cyclase2
ATP Pyrophosphate-Lyase 12 3     Adenylate Cyclase Type 12

External Ids:    HGNC: 2321   Entrez Gene: 1072   Ensembl: ENSG000001647427   OMIM: 1030725   UniProtKB: Q088283   

Export aliases for ADCY1 gene to outside databases

Previous GC identifers: GC07P045296 GC07P045354 GC07P045387


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ADCY1:
This gene encodes a form of adenylate cyclase expressed in brain. A similar protein in mouse is involved in pattern
formation of the brain. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central
nervous system. It may play a role in memory acquisition and learning

summary for ADCY1:
Adenylyl Cyclases (AC) are a group of enzymes that convert adenosine-5'-triphosphate (ATP) into
3',5'-adenosine monophosphate (cAMP) and pyrophosphate. There are ten different mammalian isoforms of AC;
nine are membrane-bound, which are all found in, but not limited to, excitable tissues such as neurons and
muscle, and one soluble form (sAC), which is expressed predominantly in the testis. The ten adenylyl cyclase
isoforms can be divided into five distinct families based on their functional attributes; AC1, AC3 and AC8
are Ca2+-calmodulin-sensitive; AC2, AC4 and AC7 are Gbetagamma-stimulatory forms; AC5 and AC6 are
distinguished by their insensitivity to inhibition by both Ca2+ and Galphai; AC9 is forskolin-insensitive
and sAC is similar to cyanobacteria AC. Adenylyl cyclases are regulated by post-translational modifications,
phosphorylation, G proteins, forskolin, pyrophosphate, calcium and calmodulin and the functions of this
enzyme are diverse. Perturbations in adenylyl cyclase activity has been implicated in alcholol and opioid
addiction and is associated with human diseases, including thyroid adenoma, male precocious puberty and
chondrodysplasia.

Gene Wiki entry for ADCY1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007819.17  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCY1 gene promoter:
         GR   FOXF2   NF-AT   CREB   FAC1   NF-AT2   deltaCREB   Chx10   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 8): ADCY1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCY1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13-p12   Ensembl cytogenetic band:  7p12.3   HGNC cytogenetic band: 7p13-p12

ADCY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCY1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P045580:  view genomic region     (about GC identifiers)

Start:
45,613,739 bp from pter      End:
45,762,715 bp from pter
Size:
148,977 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 45,653,346-45,802,046     

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828 (See protein sequence)
Recommended Name: Adenylate cyclase type 1  
Size: 1119 amino acids; 123440 Da
Cofactor: Binds 2 magnesium ions per subunit (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A4D2L8 Q75MI1

Explore the universe of human proteins at neXtProt for ADCY1: NX_Q08828

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q08828

  • 4/14 DME Specific Peptides for ADCY1 (Q08828) (see all 14)
     WQYDVWS  ADIVGFT  FHKIYIQ  TVNVASR 

    ADCY1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_066939.1  
    ENSEMBL proteins: 
     ENSP00000392721   ENSP00000297323  
    Reactome Protein details: Q08828
    Human Recombinant Protein Products: 
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    Uscn Proteins for ADCY1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS--


    ADCY1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ADCY1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ADCY1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001054 A/G_cyclase
     IPR018297 A/G_cyclase_CS

    Graphical View of Domain Structure for InterPro Entry Q08828

    ProtoNet protein and cluster: Q08828

    1 Blocks protein family: IPB009398 Adenylate cyclase-like

    UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
    Similarity: Belongs to the adenylyl cyclase class-4/guanylyl cyclase family
    Similarity: Contains 2 guanylate cyclase domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
    Function: This is a calmodulin-sensitive adenylyl cyclase. May be involved in regulatory processes in the central
    nervous system. It may play a role in memory acquisition and learning
    Catalytic activity: ATP = 3',5'-cyclic AMP + diphosphate
    Enzyme regulation: Activated by calcium/calmodulin. Inhibited by the G protein beta and gamma subunit complex

         Genatlas biochemistry entry for ADCY1:
    adenylyl cyclase,type I,calmodulin sensitive,fetal brain

    Enzyme Number (IUBMB): EC 4.6.1.11 2

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    hsa-miR-124* hsa-miR-3130-5p hsa-miR-199a-3p hsa-miR-4272 hsa-miR-3653 hsa-miR-374a hsa-miR-4275 hsa-miR-149
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCY1

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0004016adenylate cyclase activity ----
    GO:0005516calmodulin binding NAS--
    GO:0005524ATP binding IEA--
    GO:0008294calcium- and calmodulin-responsive adenylate cyclase activity NAS8314585


    ADCY1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for ADCY1: Adcy1tm1.1Ito Adcy1tm1Drs
         4 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Adcy1):
     behavior/neurological  homeostasis/metabolism  integument  nervous system 

    ADCY1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/74 super-pathways (see all 74About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Signaling by FGFR
    8/12 pathways (see all 12)
    Signaling by FGFR1.00
    DAP12 signaling0.83
    Downstream signaling of activated FGFR0.92
    Signaling by EGFR in Cancer0.83
    Signaling by FGFR in disease0.91
    DAP12 interactions0.76
    Signaling by ERBB20.89
    Signaling by PDGF0.72
    2PKA activation in glucagon signalling
    8/12 pathways (see all 12)
    PKA activation in glucagon signalling1.00
    Neurophysiological process_PGE2-induced pain processing0.44
    PKA activation0.94
    Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling0.37
    PKA-mediated phosphorylation of CREB0.89
    Development_Role of Activin A in cell differentiation and proliferation0.33
    Regulation of CFTR gating (normal and CF)0.76
    Development Role of Activin A in cell differentiation and proliferation0.33
    3DAG and IP3 signaling
    DAG and IP3 signaling1.00
    CaM pathway0.84
    PLC-gamma1 signalling0.94
    Calmodulin induced events0.84
    EGFR interacts with phospholipase C-gamma0.94
    Ca-dependent events0.79
    PLCG1 events in ERBB2 signaling0.91
    Phospholipase C-mediated cascade0.57
    4G-protein signaling_G-Protein alpha-i signaling cascades
    G-protein signaling_G-Protein alpha-i signaling cascades1.00
    Development Beta-adrenergic receptors regulation of ERK0.55
    G-protein signaling G-Protein alpha-i signaling cascades1.00
    G-protein signaling_G-Protein alpha-s signaling cascades0.44
    Development_Beta-adrenergic receptors regulation of ERK0.55
    G-protein signaling G-Protein alpha-s signaling cascades0.44
    5Regulation of Water Balance by Renal Aquaporins
    Regulation of Water Balance by Renal Aquaporins1.00
    G alpha (z) signalling events0.48
    Aquaporin-mediated transport0.84
    Cytoskeleton remodeling_Role of PKA in cytoskeleton reorganisation0.40
    Glucagon signaling in metabolic regulation0.69
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation0.40

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/21 EMD Millipore Pathways for ADCY1 (see all 21)
        Adenylate cyclase-activating neuropeptides
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Development A1 receptor signaling
    Transcription PPAR Pathway
    Development Role of Activin A in cell differentiation and proliferation

    5/44 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ADCY1 (see all 44)
        Molecular Mechanisms of Cancer
    Intracellular Calcium Signaling
    CDK5 Pathway
    PACAP Signaling
    P2Y Receptor Signaling

    5/24 GeneGo (Thomson Reuters) Pathways for ADCY1 (see all 24)
        Signal transduction cAMP signaling
    Development Endothelin-1/EDNRA signaling
    Transcription PPAR Pathway
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    G-protein signaling G-Protein alpha-i signaling cascades

    5/7 BioSystems Pathways for ADCY1 (see all 7
        Calcium Regulation in the Cardiac Cell
    Myometrial Relaxation and Contraction Pathways
    Hypothetical Network for Drug Addiction
    G Protein Signaling Pathways
    LPA receptor mediated events

    5/53        Reactome Pathways for ADCY1 (see all 53)
        PKA activation
    Signaling by EGFR in Cancer
    Post NMDA receptor activation events
    G alpha (z) signalling events
    Downstream signal transduction

    3 PharmGKB Pathways for ADCY1
        Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
    Proton Pump Inhibitor Pathway, Pharmacodynamics
    Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics

    5/19         Kegg Pathways  (Kegg details for ADCY1) (see all 19):
        Purine metabolism
    Calcium signaling pathway
    Chemokine signaling pathway
    Oocyte meiosis
    Vascular smooth muscle contraction


    ADCY1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/300 Interacting proteins for ADCY1 (Q088283 ENSP000002973234) via UniProtKB, MINT, STRING, and/or I2D (see all 300)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2Q084623, ENSP000003429524I2D: score=1 STRING: ENSP00000342952
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY5ENSP000004193614STRING: ENSP00000419361
    ADCY6ENSP000003114054STRING: ENSP00000311405
    About this table

    Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006112energy reserve metabolic process TAS--
    GO:0006171cAMP biosynthetic process NAS--
    GO:0006833water transport TAS--
    GO:0007165signal transduction TAS--
    GO:0007173epidermal growth factor receptor signaling pathway TAS--


    ADCY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADCY1 for compounds           About GeneDecksing

    EMD Millipore small molecules for ADCY1:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ADCY1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BPIPPNon-competitive GC inhibitor. Also AC inhibitor[325746-94-9]
    NKH 477Water-soluble adenylyl cyclase activator[138605-00-2]
    ForskolinAdenylyl cyclase activator[66575-29-9]
    SQ 22536Adenylyl cyclase inhibitor[17318-31-9]
    PACAP 1-38Potent stimulator of adenylyl cyclase--

    10/12 HMDB Compounds for ADCY1 (see all 12)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--
    Cyclic GMP3',5'-cyclic GMP (see all 13)7665-99-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    MagnesiumMagnesium (see all 2)7439-95-4--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADH1,4-Dihydronicotinamide adenine dinucleotide (see all 17)58-68-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--

    2 DrugBank Compounds for ADCY1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Adenosine monophosphate5'-Adenosine monophosphate (see all 15)61-19-8targetproduct of11752352 16895552 17229090
    Adenosine triphosphate5'-ATP (see all 8)56-65-5target--17139284 17016423

    10/34 Novoseek chemical compound relationships for ADCY1 gene (see all 34)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    forskolin 71.5 18 8853375 (2), 8392469 (1), 17611668 (1), 7704910 (1) (see all 15)
    2',5'-dideoxyadenosine 69.6 7 7512387 (1), 17294519 (1), 7530840 (1)
    cyclic amp 66.6 10 11515719 (2), 1847586 (1), 15845377 (1), 16201743 (1) (see all 8)
    1,9-dideoxyforskolin 61.8 1 8853375 (1)
    dbc-amp 59.4 3 1829779 (1), 8625744 (1), 1372296 (1)
    ibmx 55.2 7 8853375 (2), 7704910 (1), 7530840 (1), 12372804 (1) (see all 5)
    isoproterenol 52.6 4 1711430 (2), 1702264 (1), 1981962 (1)
    adenylate 43.5 6 20496301 (1), 9763301 (1), 16297936 (1), 9176812 (1) (see all 5)
    theophylline 29.2 2 12359956 (1), 7704910 (1)
    salbutamol 26.8 1 1981962 (1)

    Search CenterWatch for drugs/clinical trials and news about ADCY1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADCY1 gene: 
    NM_021116.2  

    Unigene Cluster for ADCY1:

    Adenylate cyclase 1 (brain)
    Hs.192215  [show with all ESTs]
    Unigene Representative Sequence: NM_021116
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000432715(uc003tnd.3) ENST00000297323(uc003tne.4) ENST00000468353


    miRNA
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    8/109 QIAGEN miScript miRNA Assays for microRNAs that regulate ADCY1 (see all 109):
    hsa-miR-124* hsa-miR-3130-5p hsa-miR-199a-3p hsa-miR-4272 hsa-miR-3653 hsa-miR-374a hsa-miR-4275 hsa-miR-149
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    Additional cDNA sequence: 

    AB209496.1 AF086306.1 AF497515.1 AK024415.1 AK055343.1 AK095518.1 AK095665.1 BC036858.1 
    BC041473.1 L05500.1 

    4 DOTS entries:

    DT.115205  DT.453040  DT.100790903  DT.101975235 

    24/167 AceView cDNA sequences (see all 167):

    AL534368 BX101242 AK055343 AI858804 AL706851 CR612961 CA334785 AA325723 
    CB161607 AF086306 AA351841 BM932315 AW058472 CB162512 NM_021116 T33055 
    AI858628 L05500 AA497018 BC041473 BQ638576 BM926997 BM926775 BX095677 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCY1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATAGATTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See ADCY1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCY1

    SOURCE GeneReport for Unigene cluster: Hs.192215

    UniProtKB/Swiss-Prot: ADCY1_HUMAN, Q08828
    Tissue specificity: Brain, retina and adrenal medulla

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADCY1 gene from 5/21 species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ADCY11 adenylate cyclase 1 (brain) 74.53(n)
    82.92(a)
      420788  XM_418883.3  XP_418883.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADCY16
    --
    78(a)
    1 ↔ 1
    6(53653162-53807636)
    zebrafish
    (Danio rerio)
    Actinopterygii adcy1a1 adenylate cyclase 1a 70.87(n)
    74.14(a)
      557026  NM_001168349.1  NP_001161821.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rut1 , 3 molting cycle (sensu Insecta) adenylate
    cyclase3
    rutabaga1
    41(a)3
    55.12(n)1
    46.71(a)1
      12F43
    324061  NM_078601.31  NP_511156.21 
    worm
    (Caenorhabditis elegans)
    Secernentea acy-43   -- 51(a)   V(5627531-5629064)   --


    ENSEMBL Gene Tree for ADCY1 (if available)
    TreeFam Gene Tree for ADCY1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCY1 gene
    ADCY52  ADCY22  GUCY2D2  GUCY2C2  NPR12  ADCY82  GUCY2F2  GUCY1A22  
    ADCY72  ADCY92  GUCY1B32  ADCY62  GUCY1A32  ADCY42  NPR22  ADCY32  
    9 SIMAP similar genes for ADCY1 using alignment to 5 protein entries:     ADCY1_HUMAN (see all proteins):
    ADCY6    ADCY5    ADCY3    ADCY8    ADCY7    ADCY4
    ADCY2    NPR1    DKFZp686J099

    ADCY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2582 NCBI SNPs in ADCY1 are shown (see all 2582    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1425265501,2
    --45612161(+) ACTTGA/GAAAGA 1 -- us2k10--------
    rs1875489121,2
    --45612229(+) AAGGTG/TCTTTC 1 -- us2k10--------
    rs1925481101,2
    --45612279(+) GAGCCA/GGTGCT 1 -- us2k10--------
    rs1167622681,2
    F,--45612350(+) CAGAGT/CGGTGG 1 -- us2k12Minor allele frequency- C:0.08WA EA 238
    rs787158811,2
    F,--45612640(+) AAAAAC/TGGCAA 1 -- us2k12Minor allele frequency- T:0.08WA EA 238
    rs1379758271,2
    C,--45612712(+) TTGTT-/CCCGTA 1 -- us2k10--------
    rs1824411801,2
    --45612772(+) TAAAAC/TAGACC 1 -- us2k10--------
    rs1441542411,2
    --45612892(+) CCATAC/TTGAGG 1 -- us2k10--------
    rs1879634081,2
    --45612933(+) GCAGGA/GGTTCT 1 -- us2k10--------
    rs1926434031,2
    --45612999(+) CACTGC/TAAGGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCY1 (45613739 - 45762715 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for ADCY1
         1 CNV: 10185
         1 Indel: 69872

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADCY1 for disorders           About GeneDecksing

    OMIM gene information: 103072    OMIM disorders: --

    20/43 diseases for ADCY1 (see all 43):    About MalaCards
    precocious puberty    thyroid adenoma    chondrodysplasia    adenoma
    thyroiditis    mccune albright syndrome    type 2 diabetes mellitus    autism spectrum disorder
    nicotine dependence    differentiating neuroblastoma    portal hypertension    rheumatic fever
    diabetes mellitus    pseudohypoparathyroidism    chondroblastoma    neuronitis
    insulin resistance    cushing's syndrome    syncope    cholera

    1 disease from the University of Copenhagen DISEASES database for ADCY1:
    Cholera

    5 Novoseek disease relationships for ADCY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 41.4 2 12736381 (1), 1661420 (1)
    thyroid carcinoma 14.8 1 7478621 (1)
    adenoma 3.42 1 11420487 (1)
    leukemia 0 1 2154651 (1)
    ischemia 0 1 16297936 (1)

    Human Genome Epidemiology (HuGE) Navigator: ADCY1 (3 documents)

    Export disorders for ADCY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCY1 gene, integrated from 9 sources (see all 153):
    (articles sorted by number of sources associating them with ADCY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase. (PubMed id 8314585)1, 2, 3 Villacres E.C....Storm D.R. (1993)
    2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    3. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    4. CFTR-adenylyl cyclase I association responsible for U TP activation of CFTR in well-differentiated primary human bronchial cell cultu res. (PubMed id 20554763)1 Namkung W....Verkman A.S. (2010)
    5. Distinct mechanisms of regulation by Ca2+/calmodulin of type 1 and 8 adenylyl cyclases support their different physiological roles. (PubMed id 19029295)1 Masada N....Cooper D.M. (2009)
    6. Sequential use of transcriptional profiling, expressi on quantitative trait mapping, and gene association implicates MMP20 in human k idney aging. (PubMed id 19834535)1 Wheeler H.E....Kim S.K. (2009)
    7. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1 de Krom M....van Ree J.M. (2009)
    8. Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis. (PubMed id 19156168)1 Need A.C....Goldstein D.B. (2009)
    9. Overexpression of type I adenylyl cyclase in the fore brain impairs spatial memory in aged but not young mice. (PubMed id 19726641)1 Garelick M.G....Storm D.R. (2009)
    10. Calcium-mediated, purinergic stimulation and polarized localization of calcium-sensitive adenylyl cyclase isoforms in human airway epithelia. (PubMed id 17586501)1 Nlend M.C....Salathe M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 107 HGNC: 232 AceView: ADCY1 Ensembl:ENSG00000164742 euGenes: HUgn107
    ECgene: ADCY1 Kegg: 107 H-InvDB: ADCY1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADCY1 gene:
    Search GeneIP for patents involving ADCY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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