ADCK5 Gene
protein-coding GIFtS: 50
GCID: GC08P145596
|
|
aarF domain containing kinase 5
| |
Aliases
for ADCK5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| AarF Domain Containing Kinase 51 2 | | FLJ354541 | | Uncharacterized AarF Domain-Containing Protein Kinase 52 | | EC 2.7.11.-3 |
Export aliases for ADCK5 gene to outside databasesPrevious GC identifers: GC08P145201 GC08P145602 GC08P145561 GC08P140711 |
Summaries
for ADCK5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ADCK5_HUMAN, Q3MIX3Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and whattype of substrate it would phosphorylate (Ser, Thr or Tyr)
|
Genomic Views
for ADCK5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_037704.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADCK5 gene promoter:
AML1a Pax-5 NRSF form 1 NRSF form 2 Max c-Rel PPAR-gamma1 STAT3 PPAR-gamma2 c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADCK5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCK5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q24.3 Ensembl cytogenetic band: 8q24.3 HGNC cytogenetic band: 8q24.3ADCK5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08P145596: view genomic region
(about GC identifiers)
Start:
|
145,596,790 bp from pter |
End:
|
145,618,457 bp from pter |
Size:
|
21,668 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr8+,PATCHES 145,514,185-145,533,385 |
|
Proteins
for ADCK5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADCK5_HUMAN, Q3MIX3 (See
protein sequence)Recommended Name: Uncharacterized aarF domain-containing protein kinase 5 Size: 580 amino acids; 65897 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAH31570.1; Type=Erroneous initiation;
Secondary accessions: Q5U4P1 Q6P2S4 Q8N5V3Explore the universe of human proteins at neXtProt for ADCK5: NX_Q3MIX3
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3MIX3
ADCK5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_777582.3
ENSEMBL proteins: ENSP00000431875 ENSP00000310547 ENSP00000435155 ENSP00000436484
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ADCK5 for ontologies About GeneDecksing
ADCK5 Antibody Products:
Assay Products for ADCK5: |
Protein
Domains /
Families
for ADCK5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADCK5 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3MIX3ProtoNet protein and cluster: Q3MIX3 1 Blocks protein family: IPB004147 ABC1 protein
UniProtKB/Swiss-Prot: ADCK5_HUMAN, Q3MIX3Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for ADCK5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADCK5_HUMAN, Q3MIX3Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and whattype of substrate it would phosphorylate (Ser, Thr or Tyr)Enzyme Number (IUBMB): EC 2.7.11.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADCK5 (NM_174922) | |  | Sino Biological Human cDNA Clone for ADCK5 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCK5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCK5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCK5 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004674 | protein serine/threonine kinase activity |
IEA | -- |
ADCK5 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ADCK5:
|
Pathways & Interactions
for ADCK5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCK5
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for ADCK5 (Q3MIX32 ENSP000003105474) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ADCK5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADCK5
Search CenterWatch for drugs/clinical trials and news about ADCK5
|
Transcripts
for ADCK5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADCK5 gene: NM_174922.3 Unigene Cluster for ADCK5: AarF domain containing kinase 5 Hs.283374 [show with all ESTs]Unigene Representative Sequence: BC0324028 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000534714 ENST00000526231 ENST00000533715 ENST00000529654(uc003zch.3 uc003zci.3)
ENST00000308860 ENST00000525136 ENST00000532190 ENST00000526833
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK5 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK5 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADCK5 (NM_174922) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCK5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCK5 |
Additional cDNA sequence: AK092773.1 BC031570.1 BC032402.1 BC064345.1 BC085013.1 BC101659.1 BC143322.1 BC143326.1 10 DOTS entries: DT.100024901 DT.409623 DT.75178191 DT.95289249 DT.100813099 DT.95354659 DT.121469610 DT.121469613 DT.95369290 DT.97804287 24/75 AceView cDNA sequences (see all 75): BU528916 BC031570 BU622478 BC064345 AX747720 AK092773 BM930793 CR610562 BM549923 BU633298 CR605986 CA448067 NM_174922 CB106335 BM792180 BQ705949 BM919873 BC032402 BM046496 AW402168 CF140469 BG331613 BI767961 AI801085
GeneLoc Exon Structure
5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ADCK5 (see all 14) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for ADCK5
|
Expression
for ADCK5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADCK5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGCTGACCG
About this image
See ADCK5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCK5
SOURCE GeneReport for Unigene cluster: Hs.283374
SABiosciences Custom PCR Arrays for ADCK5
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCK5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCK5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCK5 |
Orthologs
for ADCK5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for ADCK5 gene from 6/27 species (see all 27) About this table
ENSEMBL Gene Tree for ADCK5 (if available)
TreeFam Gene Tree for ADCK5 (if available) |
Paralogs
for ADCK5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADCK5 gene
- ADCK12
1 SIMAP similar gene for ADCK5 using alignment to 3 protein entries: ADCK5_HUMAN (see all proteins):ADCK1
ADCK5 for paralogs About GeneDecksing
|
Genomic Variants
for ADCK5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADCK5 (145596790 - 145618457 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for ADCK5
6 CNVs: 23866 31458 70491 4613 3752 30306
2 Indels: 28847 28848 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCK5 |
|
Disorders
/ Diseases
for ADCK5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADCK5 for disorders About GeneDecksing
1  disease for ADCK5: About MalaCardsmalaria
Human Genome Epidemiology (HuGE) Navigator: ADCK5 (1 document)
Export disorders for ADCK5 gene to outside databases
|
Publications
for ADCK5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADCK5 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADCK5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ADCK5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADCK5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADCK5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADCK5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADCK5 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADCK5 gene:
Search GeneIP for patents involving ADCK5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADCK5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADCK5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADCK5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCK5 | | | OriGene Protein Over-expression Lysate for ADCK5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADCK5 | | OriGene 3'-UTR Clone for ADCK5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADCK5 | | OriGene Custom Protein Services for ADCK5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADCK5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCK5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCK5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADCK5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCK5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCK5 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ADCK5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | ADCK5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCK5 |
|  |  |  | | | | ThermoFisher Antibodies for ADCK5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCK5 |
|
|
|
|
