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Aliases for ADCK5 Gene

Aliases for ADCK5 Gene

  • AarF Domain Containing Kinase 5 2 3 5
  • EC 2.7.11.- 4

External Ids for ADCK5 Gene

Previous GeneCards Identifiers for ADCK5 Gene

  • GC08P145201
  • GC08P145602
  • GC08P145561
  • GC08P140711
  • GC08P145596

Summaries for ADCK5 Gene

GeneCards Summary for ADCK5 Gene

ADCK5 (AarF Domain Containing Kinase 5) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is ADCK1.

UniProtKB/Swiss-Prot for ADCK5 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK5 Gene

Genomics for ADCK5 Gene

Regulatory Elements for ADCK5 Gene

Enhancers for ADCK5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08F143460 1.1 Ensembl ENCODE 29.6 -910.8 -910849 3.6 HDGF TBP PKNOX1 TBL1XR1 ZNF493 THRB RAD21 RARA ZNF207 CREM ZNF623 VPS28 JRK SLC52A2 GPAA1 ADCK5 TIGD5 ZNF696 LOC105375798 MINCR
GH08F143914 1.3 FANTOM5 Ensembl ENCODE 20.3 -436.0 -435971 45.2 MLX CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF251 ZNF250 ZNF517 LRRC14 PLEC LOC105375803 ZNF696 ZNF623 VPS28 COMMD5
GH08F144455 0.8 Ensembl ENCODE 20 +83.3 83346 1.6 PKNOX1 ARNT CREB3L1 ZFP64 SIN3A ZNF2 ZNF416 ZNF207 ZNF548 FOS ZNF623 ZNF251 ZNF250 VPS28 GPAA1 LRRC14 LOC105375803 ZNF517 ZNF34 PPP1R16A
GH08F144101 0.4 ENCODE 11.1 -269.2 -269190 4.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF416 ZNF623 ZNF250 ZNF251 ZNF517 LRRC14 TMED10P1 ENSG00000255164 WDR97 ZNF696 VPS28
GH08F144059 1 ENCODE 11.1 -312.7 -312749 2.3 ATF1 CREB3L1 ARID4B DMAP1 ZNF48 ELK1 GATA2 KLF13 SP5 MXD4 MAF1 WDR97 ENSG00000255224 LRRC14 COMMD5 ZNF517 ZNF250 HSF1 ADCK5 VPS28
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADCK5 on UCSC Golden Path with GeneCards custom track

Promoters for ADCK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001446436 1299 1201 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 CBX5 ZNF207 ZNF143 KLF13 ZNF263

Genomic Location for ADCK5 Gene

Chromosome:
8
Start:
144,373,101 bp from pter
End:
144,393,242 bp from pter
Size:
20,142 bases
Orientation:
Plus strand

Genomic View for ADCK5 Gene

Genes around ADCK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK5 Gene

Proteins for ADCK5 Gene

  • Protein details for ADCK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIX3-ADCK5_HUMAN
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 5
    Protein Accession:
    Q3MIX3
    Secondary Accessions:
    • B3KS46
    • Q5U4P1
    • Q6P2S4
    • Q8N5V3

    Protein attributes for ADCK5 Gene

    Size:
    580 amino acids
    Molecular mass:
    65897 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31570.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADCK5 Gene

Post-translational modifications for ADCK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ADCK5 Gene

Domains & Families for ADCK5 Gene

Gene Families for ADCK5 Gene

Protein Domains for ADCK5 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADCK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3MIX3

UniProtKB/Swiss-Prot:

ADCK5_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK5: view

Function for ADCK5 Gene

Molecular function for ADCK5 Gene

UniProtKB/Swiss-Prot Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Enzyme Numbers (IUBMB) for ADCK5 Gene

Gene Ontology (GO) - Molecular Function for ADCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ADCK5: view
genes like me logo Genes that share phenotypes with ADCK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCK5

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADCK5

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADCK5 Gene

Localization for ADCK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCK5 Gene COMPARTMENTS Subcellular localization image for ADCK5 gene
Compartment Confidence
mitochondrion 4
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ADCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCK5: view

Pathways & Interactions for ADCK5 Gene

SuperPathways for ADCK5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with ADCK5: view

No data available for Pathways by source and SIGNOR curated interactions for ADCK5 Gene

Transcripts for ADCK5 Gene

Unigene Clusters for ADCK5 Gene

AarF domain containing kinase 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADCK5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - -
SP8: - -
SP9: - -
SP10:
SP11:
SP12:
SP13: - - - - - - -
SP14: -

ExUns: 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ADCK5 Gene

GeneLoc Exon Structure for
ADCK5
ECgene alternative splicing isoforms for
ADCK5

Expression for ADCK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ADCK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADCK5 Gene

This gene is overexpressed in Lung (33.3), Heart (13.1), and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADCK5 Gene



Protein tissue co-expression partners for ADCK5 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ADCK5 Gene:

ADCK5

SOURCE GeneReport for Unigene cluster for ADCK5 Gene:

Hs.283374
genes like me logo Genes that share expression patterns with ADCK5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADCK5 Gene

Orthologs for ADCK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADCK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCK5 34 35
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia ADCK5 34 35
  • 88.11 (n)
dog
(Canis familiaris)
Mammalia ADCK5 34 35
  • 84.83 (n)
rat
(Rattus norvegicus)
Mammalia Adck5 34
  • 81.98 (n)
mouse
(Mus musculus)
Mammalia Adck5 34 16 35
  • 81.75 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADCK5 35
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCK5 35
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCK5 35
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adck5 34 35
  • 63.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7616 34 35
  • 56.66 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006050 34
  • 55.92 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 24 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01997 34
  • 46.78 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.14c 34
  • 39.58 (n)
Species where no ortholog for ADCK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADCK5 Gene

ENSEMBL:
Gene Tree for ADCK5 (if available)
TreeFam:
Gene Tree for ADCK5 (if available)

Paralogs for ADCK5 Gene

Paralogs for ADCK5 Gene

genes like me logo Genes that share paralogs with ADCK5: view

Variants for ADCK5 Gene

Sequence variations from dbSNP and Humsavar for ADCK5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs10111654 -- 144,378,615(+) tggct(C/T)acacc intron-variant
rs1052951 -- 144,393,094(+) GGGCC(A/G)GCGGG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1052952 -- 144,393,097(+) CCGGC(A/G)GGGCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111335406 -- 144,373,907(+) TGGGG(A/G)CCGCC intron-variant, upstream-variant-2KB
rs111352341 -- 144,385,345(+) CGCCC(A/G)GCTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCK5 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12437n54 CNV loss 21841781
esv1030070 CNV insertion 17803354
esv1578252 CNV insertion 17803354
esv2759652 CNV gain+loss 17122850
nsv1076126 CNV deletion 25765185
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612934 CNV loss 21841781
nsv824805 CNV gain 20364138
nsv831489 CNV loss 17160897

Variation tolerance for ADCK5 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCK5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCK5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCK5 Gene

Disorders for ADCK5 Gene

Relevant External Links for ADCK5

Genetic Association Database (GAD)
ADCK5
Human Genome Epidemiology (HuGE) Navigator
ADCK5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCK5

No disorders were found for ADCK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCK5 Gene

Publications for ADCK5 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64

Products for ADCK5 Gene

Sources for ADCK5 Gene

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