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Aliases for ADCK5 Gene

Aliases for ADCK5 Gene

  • AarF Domain Containing Kinase 5 2 3
  • EC 2.7.11.- 4

External Ids for ADCK5 Gene

Summaries for ADCK5 Gene

GeneCards Summary for ADCK5 Gene

ADCK5 (AarF Domain Containing Kinase 5) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is ADCK1.

UniProtKB/Swiss-Prot for ADCK5 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK5 Gene

Genomics for ADCK5 Gene

Genomic Location for ADCK5 Gene

Start:
144,373,101 bp from pter
End:
144,393,242 bp from pter
Size:
20,142 bases
Orientation:
Plus strand

Genomic View for ADCK5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK5 Gene

Regulatory Elements for ADCK5 Gene

Proteins for ADCK5 Gene

  • Protein details for ADCK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIX3-ADCK5_HUMAN
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 5
    Protein Accession:
    Q3MIX3
    Secondary Accessions:
    • B3KS46
    • Q5U4P1
    • Q6P2S4
    • Q8N5V3

    Protein attributes for ADCK5 Gene

    Size:
    580 amino acids
    Molecular mass:
    65897 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH31570.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADCK5 Gene

Proteomics data for ADCK5 Gene at MOPED

Post-translational modifications for ADCK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK5 Gene

No data available for DME Specific Peptides for ADCK5 Gene

Domains for ADCK5 Gene

Gene Families for ADCK5 Gene

Protein Domains for ADCK5 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ADCK5_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q3MIX3
Family:
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.:
    • Q3MIX3
genes like me logo Genes that share domains with ADCK5: view

Function for ADCK5 Gene

Molecular function for ADCK5 Gene

UniProtKB/Swiss-Prot Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)

Enzyme Numbers (IUBMB) for ADCK5 Gene

Gene Ontology (GO) - Molecular Function for ADCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with ADCK5: view
genes like me logo Genes that share phenotypes with ADCK5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADCK5 Gene

Localization for ADCK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCK5 Gene COMPARTMENTS Subcellular localization image for ADCK5 gene
Compartment Confidence
mitochondrion 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ADCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCK5: view

Pathways for ADCK5 Gene

SuperPathways for ADCK5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with ADCK5: view

No data available for Pathways by source for ADCK5 Gene

Transcripts for ADCK5 Gene

Unigene Clusters for ADCK5 Gene

AarF domain containing kinase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - -
SP8: - -
SP9: - -
SP10:
SP11:
SP12:
SP13: - - - - - - -
SP14: -

ExUns: 17 ^ 18 ^ 19 ^ 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

Relevant External Links for ADCK5 Gene

GeneLoc Exon Structure for
ADCK5
ECgene alternative splicing isoforms for
ADCK5

Expression for ADCK5 Gene

mRNA expression in normal human tissues for ADCK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADCK5 Gene

SOURCE GeneReport for Unigene cluster for ADCK5 Gene Hs.283374

genes like me logo Genes that share expressions with ADCK5: view

Orthologs for ADCK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADCK5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCK5 36
  • 99.48 (n)
  • 99.83 (a)
ADCK5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCK5 36
  • 88.11 (n)
  • 91.67 (a)
ADCK5 37
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCK5 36
  • 84.83 (n)
  • 82.76 (a)
ADCK5 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adck5 36
  • 81.75 (n)
  • 81 (a)
Adck5 16
Adck5 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCK5 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADCK5 37
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adck5 36
  • 81.98 (n)
  • 79.97 (a)
lizard
(Anolis carolinensis)
Reptilia ADCK5 37
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adck5 36
  • 63.7 (n)
  • 61.43 (a)
adck5 37
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006050 36
  • 55.92 (n)
  • 50.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7616 36
  • 56.66 (n)
  • 48.67 (a)
CG7616 37
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 24 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU01997 36
  • 46.78 (n)
  • 33.41 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.14c 36
  • 39.58 (n)
  • 30.73 (a)
Species with no ortholog for ADCK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADCK5 Gene

ENSEMBL:
Gene Tree for ADCK5 (if available)
TreeFam:
Gene Tree for ADCK5 (if available)

Paralogs for ADCK5 Gene

Paralogs for ADCK5 Gene

genes like me logo Genes that share paralogs with ADCK5: view

Variants for ADCK5 Gene

Sequence variations from dbSNP and Humsavar for ADCK5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1383095 -- 144,390,576(+) TGGCC(A/G)GGGTG intron-variant
rs2928372 -- 144,391,895(-) CCGCC(C/G/T)TGACC intron-variant
rs2928373 -- 144,389,816(-) TTGGT(A/G)GCTCA intron-variant
rs2977837 -- 144,392,053(-) CACCC(C/T)GAGAC intron-variant
rs4269579 -- 144,384,692(+) TGGCA(A/G)GCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCK5 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7958n71 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891840 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
dgv7963n71 CNV Loss 21882294
dgv7965n71 CNV Loss 21882294
dgv7966n71 CNV Loss 21882294
nsv8397 CNV Gain 18304495
esv21877 CNV Gain+Loss 19812545
nsv821196 CNV Deletion 20802225
nsv512079 CNV Loss 21212237
esv1669507 CNV Deletion 17803354
esv1712288 CNV Deletion 17803354
esv1695178 CNV Deletion 17803354
dgv7967n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
esv1030070 CNV Insertion 17803354
esv1578252 CNV Insertion 17803354
nsv891870 CNV Loss 21882294
nsv824805 CNV Gain 20364138

Relevant External Links for ADCK5 Gene

HapMap Linkage Disequilibrium report
ADCK5

Disorders for ADCK5 Gene

Relevant External Links for ADCK5

Genetic Association Database (GAD)
ADCK5
Human Genome Epidemiology (HuGE) Navigator
ADCK5
genes like me logo Genes that share disorders with ADCK5: view

No data available for UniProtKB/Swiss-Prot for ADCK5 Gene

Publications for ADCK5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C. … Lander E.S. (Nature 2006) 3 4
  4. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ADCK5 Gene

  • Addgene plasmids for ADCK5

Sources for ADCK5 Gene

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