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Aliases for ADCK5 Gene

Aliases for ADCK5 Gene

  • AarF Domain Containing Kinase 5 2 3 5
  • EC 2.7.11.- 4

External Ids for ADCK5 Gene

Previous GeneCards Identifiers for ADCK5 Gene

  • GC08P145201
  • GC08P145602
  • GC08P145561
  • GC08P140711
  • GC08P145596

Summaries for ADCK5 Gene

GeneCards Summary for ADCK5 Gene

ADCK5 (AarF Domain Containing Kinase 5) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is ADCK1.

UniProtKB/Swiss-Prot for ADCK5 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK5 Gene

Genomics for ADCK5 Gene

Regulatory Elements for ADCK5 Gene

Enhancers for ADCK5 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADCK5 on UCSC Golden Path with GeneCards custom track

Promoters for ADCK5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADCK5 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADCK5 Gene

144,373,101 bp from pter
144,393,242 bp from pter
20,142 bases
Plus strand

Genomic View for ADCK5 Gene

Genes around ADCK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK5 Gene

Proteins for ADCK5 Gene

  • Protein details for ADCK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 5
    Protein Accession:
    Secondary Accessions:
    • B3KS46
    • Q5U4P1
    • Q6P2S4
    • Q8N5V3

    Protein attributes for ADCK5 Gene

    580 amino acids
    Molecular mass:
    65897 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH31570.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ADCK5 Gene

Proteomics data for ADCK5 Gene at MOPED

Post-translational modifications for ADCK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK5 Gene

Antibody Products

  • Abcam antibodies for ADCK5

No data available for DME Specific Peptides for ADCK5 Gene

Domains & Families for ADCK5 Gene

Gene Families for ADCK5 Gene

Protein Domains for ADCK5 Gene


Suggested Antigen Peptide Sequences for ADCK5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK5: view

Function for ADCK5 Gene

Molecular function for ADCK5 Gene

UniProtKB/Swiss-Prot Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Enzyme Numbers (IUBMB) for ADCK5 Gene

Gene Ontology (GO) - Molecular Function for ADCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
genes like me logo Genes that share ontologies with ADCK5: view
genes like me logo Genes that share phenotypes with ADCK5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCK5

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADCK5 Gene

Localization for ADCK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK5 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADCK5 Gene COMPARTMENTS Subcellular localization image for ADCK5 gene
Compartment Confidence
mitochondrion 4
cytosol 3
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ADCK5 Gene

Pathways & Interactions for ADCK5 Gene

SuperPathways for ADCK5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADCK5 Gene


No data available for Pathways by source and SIGNOR curated interactions for ADCK5 Gene

Drugs & Compounds for ADCK5 Gene

No Compound Related Data Available

Transcripts for ADCK5 Gene

Unigene Clusters for ADCK5 Gene

AarF domain containing kinase 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK5 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6: -
SP7: - - -
SP8: - -
SP9: - -
SP13: - - - - - - -
SP14: -

ExUns: 17 ^ 18 ^ 19 ^ 20

Relevant External Links for ADCK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCK5 Gene

mRNA expression in normal human tissues for ADCK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADCK5 Gene

This gene is overexpressed in Lung (33.3), Heart (13.1), and Testis (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADCK5 Gene

SOURCE GeneReport for Unigene cluster for ADCK5 Gene Hs.283374

genes like me logo Genes that share expression patterns with ADCK5: view

Protein tissue co-expression partners for ADCK5 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADCK5 Gene

Orthologs for ADCK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADCK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCK5 35
  • 88.11 (n)
  • 91.67 (a)
ADCK5 36
  • 84 (a)
(Canis familiaris)
Mammalia ADCK5 35
  • 84.83 (n)
  • 82.76 (a)
ADCK5 36
  • 81 (a)
(Mus musculus)
Mammalia Adck5 35
  • 81.75 (n)
  • 81 (a)
Adck5 16
Adck5 36
  • 80 (a)
(Pan troglodytes)
Mammalia ADCK5 35
  • 99.48 (n)
  • 99.83 (a)
ADCK5 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Adck5 35
  • 81.98 (n)
  • 79.97 (a)
(Monodelphis domestica)
Mammalia ADCK5 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ADCK5 36
  • 75 (a)
(Anolis carolinensis)
Reptilia ADCK5 36
  • 61 (a)
(Danio rerio)
Actinopterygii adck5 35
  • 63.7 (n)
  • 61.43 (a)
adck5 36
  • 60 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006050 35
  • 55.92 (n)
  • 50.35 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7616 35
  • 56.66 (n)
  • 48.67 (a)
CG7616 36
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 24 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01997 35
  • 46.78 (n)
  • 33.41 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC10F6.14c 35
  • 39.58 (n)
  • 30.73 (a)
Species with no ortholog for ADCK5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADCK5 Gene

Gene Tree for ADCK5 (if available)
Gene Tree for ADCK5 (if available)

Paralogs for ADCK5 Gene

Paralogs for ADCK5 Gene

genes like me logo Genes that share paralogs with ADCK5: view

Variants for ADCK5 Gene

Sequence variations from dbSNP and Humsavar for ADCK5 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs6599528 - 144,379,425(+) CACAG(A/C)AGGCA nc-transcript-variant, reference, missense, utr-variant-5-prime
rs7830004 -- 144,374,898(+) GGGGG(C/G)GGGGC intron-variant, upstream-variant-2KB
rs7843675 -- 144,392,695(+) GCTAA(A/G)AGGTC nc-transcript-variant, reference, synonymous-codon
rs9801979 -- 144,382,214(+) CCTGC(C/T)GCACT intron-variant
rs2928372 -- 144,391,895(-) CCGCC(C/G/T)TGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCK5 Gene

Variant ID Type Subtype PubMed ID
nsv470249 CNV Loss 18288195
nsv515809 CNV Gain+Loss 19592680
nsv891807 CNV Loss 21882294
nsv428208 CNV Gain 18775914
nsv891817 CNV Loss 21882294
dgv7958n71 CNV Loss 21882294
dgv7959n71 CNV Loss 21882294
nsv891840 CNV Loss 21882294
nsv891841 CNV Loss 21882294
nsv891844 CNV Loss 21882294
nsv891845 CNV Gain 21882294
nsv891846 CNV Loss 21882294
dgv2264e1 CNV Complex 17122850
nsv831489 CNV Loss 17160897
dgv7963n71 CNV Loss 21882294
dgv7965n71 CNV Loss 21882294
dgv7966n71 CNV Loss 21882294
nsv8397 CNV Gain 18304495
esv21877 CNV Gain+Loss 19812545
nsv821196 CNV Deletion 20802225
nsv512079 CNV Loss 21212237
esv1669507 CNV Deletion 17803354
esv1712288 CNV Deletion 17803354
esv1695178 CNV Deletion 17803354
dgv7967n71 CNV Loss 21882294
dgv7968n71 CNV Loss 21882294
dgv7969n71 CNV Loss 21882294
esv1030070 CNV Insertion 17803354
esv1578252 CNV Insertion 17803354
nsv891870 CNV Loss 21882294
nsv824805 CNV Gain 20364138

Variation tolerance for ADCK5 Gene

Residual Variation Intolerance Score: 72.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.62% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADCK5 Gene

Disorders for ADCK5 Gene

Relevant External Links for ADCK5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADCK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCK5 Gene

Publications for ADCK5 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T. … Xu J. (Neurobiol. Aging 2015) 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ADCK5 Gene

Sources for ADCK5 Gene