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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCK5 Gene

protein-coding   GIFtS: 50
GCID: GC08P145596

AarF Domain Containing Kinase 5

  Search for ADCK5
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AarF Domain Containing Kinase 51 2
Uncharacterized AarF Domain-Containing Protein Kinase 52
EC 2.7.11.-3

External Ids:    HGNC: 217381   Entrez Gene: 2030542   Ensembl: ENSG000001731377   UniProtKB: Q3MIX33   

Export aliases for ADCK5 gene to outside databases

Previous GC identifers: GC08P145201 GC08P145602 GC08P145561 GC08P140711


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ADCK5 Gene: 
ADCK5 (aarF domain containing kinase 5) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is ADCK1.

UniProtKB/Swiss-Prot: ADCK5_HUMAN, Q3MIX3
Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and
what type of substrate it would phosphorylate (Ser, Thr or Tyr)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_037704.5  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADCK5 gene promoter:
         AML1a   Pax-5   NRSF form 1   NRSF form 2   Max   c-Rel   PPAR-gamma1   STAT3   PPAR-gamma2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADCK5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCK5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCK5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q24.3   Ensembl cytogenetic band:  8q24.3   HGNC cytogenetic band: 8q24.3

ADCK5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCK5 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P145596:  view genomic region     (about GC identifiers)

Start:
145,596,790 bp from pter      End:
145,618,457 bp from pter
Size:
21,668 bases      Orientation:
plus strand

1 alternative location:
Chr8+,NW_003315924 143,301-162,501     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADCK5_HUMAN, Q3MIX3 (See protein sequence)
Recommended Name: Uncharacterized aarF domain-containing protein kinase 5  
Size: 580 amino acids; 65897 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAH31570.1; Type=Erroneous initiation;
Secondary accessions: Q5U4P1 Q6P2S4 Q8N5V3

Explore the universe of human proteins at neXtProt for ADCK5: NX_Q3MIX3

Explore proteomics data for ADCK5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3MIX3

  • ADCK5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADCK5 Protein Expression
    REFSEQ proteins: NP_777582.4  
    ENSEMBL proteins: 
     ENSP00000473494   ENSP00000431875   ENSP00000310547   ENSP00000435155   ENSP00000436484  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ADCK5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0016021integral to membrane IEA--

    ADCK5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: aarF domain containing kinase 5 
    ABC1-B subfamily

    2 InterPro protein domains:
     IPR004147 UbiB_dom
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q3MIX3

    ProtoNet protein and cluster: Q3MIX3

    1 Blocks protein domain: IPB004147 ABC1 protein

    UniProtKB/Swiss-Prot: ADCK5_HUMAN, Q3MIX3
    Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family
    Similarity: Contains 1 protein kinase domain


    ADCK5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADCK5_HUMAN, Q3MIX3
    Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and
    what type of substrate it would phosphorylate (Ser, Thr or Tyr)

         Enzyme Number (IUBMB): EC 2.7.11.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    ADCK5 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for ADCK5:
     Decreased 12E8 tau but not tot  Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADCK5 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCK5

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for ADCK5 (Q3MIX32 ENSP000003105474) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HSPA6ENSP000003102194STRING: ENSP00000310219
    RHODENSP000003085764STRING: ENSP00000308576
    --P310162MINT-8107659
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADCK5

    Search CenterWatch for drugs/clinical trials and news about ADCK5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADCK5 gene: 
    NM_174922.4  

    Unigene Cluster for ADCK5:

    AarF domain containing kinase 5
    Hs.283374  [show with all ESTs]
    Unigene Representative Sequence: BC032402
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000534714 ENST00000526231 ENST00000533715 ENST00000529654(uc003zch.3 uc003zci.3)
    ENST00000308860 ENST00000525136 ENST00000532190 ENST00000526833
    miRNA
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    Additional mRNA sequence: 

    AK092773.1 BC031570.1 BC032402.1 BC064345.1 BC085013.1 BC101659.1 BC143322.1 BC143326.1 

    10 DOTS entries:

    DT.100024901  DT.409623  DT.75178191  DT.95289249  DT.100813099  DT.95354659  DT.121469610  DT.121469613 
    DT.95369290  DT.97804287 

    24/75 AceView cDNA sequences (see all 75):

    BM930793 BC064345 BC031570 BU622478 NM_174922 CR610562 AX747720 BU528916 
    BM792180 CB106335 CA448067 BQ705949 BU633298 BM549923 AK092773 CR605986 
    BQ929476 BM146288 BI918384 CA307986 CB851629 CF140540 BU526818 BM043279 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ADCK5 (see all 14)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^
    SP1:                                -     -                       -     -                                                                       -               
    SP2:                                -                             -     -                                                                                       
    SP3:                                -     -                       -     -                                                                                       
    SP4:                                -     -                             -                                                                                       
    SP5:                                                                    -                                                                                       

    ExUns: 17 ^ 18 ^ 19 ^ 20
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ADCK5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCK5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGCTGACCG
    ADCK5 Expression
    About this image


    See ADCK5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCK5

    SOURCE GeneReport for Unigene cluster: Hs.283374
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCK5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADCK5 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adck51 , 5 aarF domain containing kinase 51, 5 81.69(n)1
    80.83(a)1
      15 (36.10 cM)5
    2688221  NM_172960.31  NP_766548.21 
     765763585 
    lizard
    (Anolis carolinensis)
    Reptilia ADCK56
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343636.1(103791-138111)
    zebrafish
    (Danio rerio)
    Actinopterygii adck51 aarF domain containing kinase 5 63.47(n)
    61.15(a)
      100001584  NM_001202526.1  NP_001189455.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG76161 CG7616 56.66(n)
    48.67(a)
      39260  NM_140189.2  NP_648446.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YLR253W6
    Putative protein of unknown function; the authenti...
    23(a)
    1 → many
    XII(642627-644336)


    ENSEMBL Gene Tree for ADCK5 (if available)
    TreeFam Gene Tree for ADCK5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCK5 gene
    ADCK12  
    18/22 SIMAP similar genes for ADCK5 using alignment to 4 protein entries:     ADCK5_HUMAN (see all proteins) (see all similar genes):
    AURA2    DCTN5    DNMT1    NF2    RNF217    ZNF28
    TMSB15B    APOD    FAM210A    NSRP1    ZNF737    TSEN2
    LOC100506792    ZNF461    ZNF738    KDM5B    BECN1    UTY

    ADCK5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/547 SNPs in ADCK5 are shown (see all 547)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1454168681,2
    C--145595855(+) CTCCCA/GGGATG 1 -- us2k10--------
    rs1411794981,2
    C--145595888(+) CCTTCA/GTTCAT 1 -- us2k10--------
    rs1870607421,2
    --145596055(+) CTCACA/GTCACG 1 -- us2k10--------
    rs1157641991,2
    C,F--145596138(+) GTTGCC/TGAGGG 1 -- us2k12Minor allele frequency- T:0.04WA NA 238
    rs756744221,2
    C,F--145596535(+) GGGCCA/CCTTGT 1 -- us2k15Minor allele frequency- C:0.50NA CSA EA 245
    rs1914849241,2
    --145596555(+) AGGGGC/TCACTG 1 -- us2k10--------
    rs1842782641,2
    C--145596624(+) GGCCAC/TTGGTG 1 -- us2k10--------
    rs1887788931,2
    C--145596626(+) CCACTG/TGTGGG 1 -- us2k10--------
    rs1449936531,2
    --145596712(+) GGCCAC/TTGGTG 1 -- us2k10--------
    rs1388650601,2
    --145596808(+) GCCAAA/GCTGAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCK5 (145596790 - 145618457 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/31 variations for ADCK5 (see all 31):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1669507CNV Deletion17803354
    esv1712288CNV Deletion17803354
    esv1695178CNV Deletion17803354
    nsv821196CNV Deletion20802225
    esv1030070CNV Insertion17803354
    esv1578252CNV Insertion17803354
    dgv7966n71CNV Loss21882294
    nsv891841CNV Loss21882294
    nsv891846CNV Loss21882294
    nsv512079CNV Loss21212237

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADCK5 for disorders           About MalaCards

    ADCK5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADCK5
    Human Genome Epidemiology (HuGE) Navigator: ADCK5 (1 document)

    Export disorders for ADCK5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCK5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADCK5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    2. DNA sequence and analysis of human chromosome 8. (PubMed id 16421571)1, 2 Nusbaum C....Lander E.S. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    5. The SH3 domain of postsynaptic density 95 mediates inf lammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (2010)
    6. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 203054 HGNC: 21738 AceView: ADCK5 Ensembl:ENSG00000173137 euGenes: HUgn203054
    ECgene: ADCK5 H-InvDB: ADCK5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCK5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADCK5 gene:
    Search GeneIP for patents involving ADCK5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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