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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADCK3 Gene

protein-coding   GIFtS: 54
GCID: GC01P227087

aarF domain containing kinase 3

(Previous names: chaperone-ABC1 (activity of bc1 complex, S.pombe)-like,...)
(Previous symbol: CABC1)
 Explore 11 diseases affiliated with
ADCK3 via
MalaCards
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 Human Malady Compendium 
Biological research products
for ADCK3    

Aliases
for ADCK3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
AarF Domain Containing Kinase 31 2     Chaperone-ABC1 (Activity Of Bc1 Complex, S.Pombe)-Like1
CABC11 2 3 5     COQ10D42
COQ81 2 5     Chaperone Activity Of Bc1 Complex-Like, Mitochondrial2
SCAR91 2 5     Chaperone, ABC1 Activity Of Bc1 Complex Homolog2
AarF Domain-Containing Protein Kinase 32 3     Coenzyme Q8 Homolog2
ARCA22 5     Chaperone-ABC1-Like1
Chaperone, ABC1 Activity Of Bc1 Complex Homolog (S. Pombe)1     EC 2.7.11.-3
Chaperone, ABC1 Activity Of Bc1 Complex Like (S. Pombe)1     EC 2.7.118

External Ids:    HGNC: 168121   Entrez Gene: 569972   Ensembl: ENSG000001630507   OMIM: 6069805   UniProtKB: Q8NI603   

Export aliases for ADCK3 gene to outside databases


Summaries
for ADCK3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADCK3:
This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane
protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of
this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression
partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their
full-length nature has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ADCK3_HUMAN, Q8NI60
Function: May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in
the respiratory chain

Gene Wiki entry for ADCK3 (CABC1)


Genomic Views
for ADCK3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ADCK3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADCK3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADCK3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.13   Ensembl cytogenetic band:  1q42.13   HGNC cytogenetic band: 1q42.11

ADCK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADCK3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P227087:  view genomic region     (about GC identifiers)

Start:
 227,085,237 bp from pter      End:
 227,175,246 bp from pter
Size:
 90,010 bases      Orientation:
 plus strand

Proteins
for ADCK3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ADCK3_HUMAN, Q8NI60 (See protein sequence)
Recommended Name: Chaperone activity of bc1 complex-like, mitochondrial precursor  
Size: 647 amino acids; 71950 Da
Subcellular location: Mitochondrion
Caution: It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr
or Tyr)
Secondary accessions: Q5T7A5 Q63HK0 Q8NCJ6 Q9HBQ1 Q9NQ67
Alternative splicing: 4 isoforms:  Q8NI60-1   Q8NI60-2   Q8NI60-3   Q8NI60-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADCK3: NX_Q8NI60

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8NI60

    • 2 DME Specific Peptides for ADCK3 (Q8NI60)
     PPPEETY  AAASIGQVH 

    ADCK3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_064632.2  
    ENSEMBL proteins: 
     ENSP00000355741   ENSP00000355740   ENSP00000355739   ENSP00000355738   ENSP00000355737  
     ENSP00000403704   ENSP00000404550  

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    Novus Biologicals ADCK3 Proteins
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    Uscn Proteins for ADCK3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--


    ADCK3 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADCK3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADCK3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004147 UbiB_dom
     IPR011009 Kinase-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8NI60

    ProtoNet protein and cluster: Q8NI60

    1 Blocks protein family: IPB004147 ABC1 protein

    UniProtKB/Swiss-Prot: ADCK3_HUMAN, Q8NI60
    Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family
    Similarity: Contains 1 protein kinase domain


    Function
    for ADCK3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ADCK3_HUMAN, Q8NI60
    Function: May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in
    the respiratory chain
    Induction: By p53/TP53

    Enzyme Numbers (IUBMB): EC 2.7.112 EC 2.7.11.-1

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----


    ADCK3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for ADCK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  Increased G1 DNA content  Increased HPV18 LCR reporter a 


    Pathways & Interactions
    for ADCK3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/258 Interacting proteins for ADCK3 (Q8NI602, 3 ENSP000003557394) via UniProtKB, MINT, STRING, and/or I2D (see all 258)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RABAC1Q9UI142, 3, ENSP000002220084MINT-66678 I2D: score=5 STRING: ENSP00000222008
    SARS2Q9NP812, 3MINT-8079030 I2D: score=1 
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    COQ5Q5HYK33, ENSP000002885324I2D: score=1 STRING: ENSP00000288532
    MAGED1Q9Y5V33, ENSP000003648474I2D: score=1 STRING: ENSP00000364847
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008219cell death IEA--


    ADCK3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADCK3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADCK3
    Search CenterWatch for drugs/clinical trials and news about ADCK3 

    Transcripts
    for ADCK3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADCK3 gene: 
    NM_020247.4  

    Unigene Cluster for ADCK3:

    AarF domain containing kinase 3
    Hs.118241  [show with all ESTs]
    Unigene Representative Sequence: NM_020247
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366779(uc001hql.1 uc001hqm.1) ENST00000485677 ENST00000366778(uc009xeq.1 uc010pvq.1)
    ENST00000366777(uc010pvp.1 uc001hqn.1) ENST00000366776(uc010pvr.1)
    ENST00000478406(uc009xer.1) ENST00000366775 ENST00000489044 ENST00000476488
    ENST00000485462(uc001hqo.1) ENST00000479852 ENST00000490782 ENST00000464693
    ENST00000458507 ENST00000433743

    miRNA
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    hsa-miR-3143 hsa-miR-3148 hsa-miR-543
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    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB073905.1 AJ278126.1 AK074693.1 AK293571.1 AK297735.1 AK300537.1 AK301012.1 AL137511.1 
    BC005171.2 BC129930.1 BX648860.1 

    19 DOTS entries:

    DT.100766408  DT.95292336  DT.95292328  DT.97810231  DT.101983834  DT.100777220  DT.95252234  DT.455359 
    DT.97822143  DT.92049843  DT.97788388  DT.121427887  DT.91850211  DT.95292312  DT.100731394  DT.121427792 
    DT.121427917  DT.121427929  DT.121427788 

    24/273 AceView cDNA sequences (see all 273):

    AW297775 AI364741 CA866033 AI953387 AL602556 BE393760 CA941010 CD672367 
    BM456221 BF724826 AI819411 AW006971 AW779751 AW271480 BF111518 CK821992 
    BM854910 AI278766 AA995563 BF195533 BM313377 AW964156 BF724827 AI916578 

    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for ADCK3 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                          -     -     -     -                                               -     -                 -     -                                 
    SP2:                          -     -     -     -           -     -     -                       -     -                 -     -                                 
    SP3:                                                                                                                    -     -                                 
    SP4:                          -     -     -     -     -     -     -     -     -     -     -     -     -                                                         
    SP5:                          -     -     -     -     -     -     -     -     -     -     -     -     -                 -     -                                 

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23
    SP1:                              
    SP2:                              
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ADCK3

    Expression
    for ADCK3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADCK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGAAGTGAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADCK3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeInterscapular Brown Adipose DepotAdipose
    AdiposeThoracic Perivascular AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See ADCK3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADCK3

    SOURCE GeneReport for Unigene cluster: Hs.118241

    UniProtKB/Swiss-Prot: ADCK3_HUMAN, Q8NI60
    Tissue specificity: Ubiquitously expressed with a relatively greater abundance in heart and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Array including ADCK3: 
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    In Situ
    Assay Products:     
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    Orthologs
    for ADCK3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ADCK3 gene from 9/32 species (see all 32)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADCK31 aarF domain containing kinase 3 72.25(n)
    76.24(a)    		   416745  NM_001199413.1  NP_001186342.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ADCK36
    		 --
    		 67(a)
    		 1 ↔ 1
    		 1(250954960-251002263)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.237472 Xenopus laevis transcribed sequence with weak similarity more 77.93(n)    CB201460.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.114732 Transcribed sequence with weak similarity to protein more 74.81(n)    CF998988.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG326496
    		 --
    		 39(a)
    		 1 → many
    		 X(12792801-12795147)
    worm
    (Caenorhabditis elegans)    		 Secernentea coq-81 Protein COQ-8 51.19(n)
    51.41(a)    		   175647  NM_065613.6  NP_498014.2 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATATH136
    AT3G077006
    (see all 10)    		 protein kinase domain-containing protein
    (see all 10)    		 9(a)
    9(a)
    (see all 10)    		 possible ortholog
    possible ortholog
    (see all 10)    		 5(25948973-25953823)
    3(2459491-2463965)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 10)    		 ELMO/CED-12 family protein, putative, expressed
    ABC1 family domain containing protein, putative, e...
    (see all 10)    		 9(a)
    9(a)
    (see all 10)    		 possible ortholog
    possible ortholog
    (see all 10)    		 2(34366517-34372513)
    2(22071620-22079414)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria ubiB6
    		 2-octaprenylphenol hydroxylase
    		 12(a)
    		 possible ortholog
    		 Chromosome(4018249-4019889)


    ENSEMBL Gene Tree for ADCK3 (if available)
    TreeFam Gene Tree for ADCK3 (if available) 

    Paralogs
    for ADCK3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADCK3 gene
    ADCK42  
    2 SIMAP similar genes for ADCK3 using alignment to 4 protein entries:     ADCK3_HUMAN (see all proteins):
    CABC1    ADCK4

    ADCK3 for paralogs           About GeneDecksing



    Genomic Variants
    for ADCK3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1024 NCBI SNPs in ADCK3 are shown (see all 1024)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1194680061,2
    		Cpathogenic227169812(+) GCGTGA/G/TTGCGG 3 D G V mis10--------
    rs1194680091,2
    		Cpathogenic227173027(+) TCACCG/AGCTAC 2 /S /G mis11Minor allele frequency- A:0.00NA 4552
    rs753328361,2
    		F,--197682615(+) ACACCC/TGCACC 1 -- int11Minor allele frequency- T:0.07EA 120
    rs1444722481,2
    		--227125990(+) CTCCTA/GTGTGG 1 -- us2k10--------
    rs75131201,2
    		C,F,H,--227125997(+) GTGGAA/GAAAGG 1 -- us2k1 trp327Minor allele frequency- G:0.45NA NS EA WA CSA 2495
    rs1164255531,2
    		F,--227126114(+) AGTGTG/TGTGGA 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1869098371,2
    		--227126126(+) ATGGGA/GGAGGC 1 -- us2k10--------
    rs353784381,2
    		C,--227126262(+) CCTAG-/GAAGAA 1 -- us2k10--------
    rs1913304591,2
    		--227126286(+) CAGAGC/TTTGTG 1 -- us2k10--------
    rs1813574391,2
    		--227126323(+) TTCTGA/TTCTTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADCK3 (227085237 - 227175246 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ADCK3: --
    Human Gene Mutation Database (HGMD): ADCK3

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCK3
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    Disorders / Diseases
    for ADCK3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADCK3 for disorders           About GeneDecksing

    OMIM gene information: 606980   
    OMIM disorders: 607426  612016  
    UniProtKB/Swiss-Prot: ADCK3_HUMAN, Q8NI60
  • Defects in ADCK3 are the cause of coenzyme Q10 deficiency, primary, type 4 (COQ10D4) [MIM:612016]. An
    • autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient
    manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes
    and Hoffmann sign, variable psychomotor retardation and variable seizures

    11 diseases for ADCK3:    About MalaCards
    spinocerebellar ataxia, autosomal recessive, 9    spinocerebellar ataxia    cerebellar ataxia    ataxia
    encephalomyopathy    seizures    pharyngitis    tuberculosis
    malaria    neuronitis    mycobacterium tuberculosis


    Export disorders for ADCK3 gene to outside databases

    Publications
    for ADCK3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADCK3 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ADCK3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency. (PubMed id 18319074)1, 2, 9 Lagier-Tourenne C....Koenig M. (2008)
    2. Isolation of a novel gene, CABC1, encoding a mitochondrial protein that is highly homologous to yeast activity of bc1 complex. (PubMed id 11888884)1, 2, 9 Iiizumi M.... Nakamura Y. (2002)
    3. CABC1 gene mutations cause ubiquinone deficiency with cerebellar ataxia and seizures. (PubMed id 18319072)1, 2, 9 Mollet J.... Roetig A. (2008)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Adult-onset cerebellar ataxia due to mutations in CABC 1/ADCK3. (PubMed id 22036850)1 Horvath R....Chinnery P.F. (2012)
    9. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. (PubMed id 21903422)1 Li S....Dorf M.E. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for ADCK3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing ADCK3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56997 HGNC: 16812 AceView: CABC1 Ensembl:ENSG00000163050 euGenes: HUgn56997
    ECgene: ADCK3 H-InvDB: ADCK3

    Other Databases showing ADCK3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ADCK3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADCK3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ADCK3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADCK3 gene:
    Search GeneIP for patents involving ADCK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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