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Aliases for ADCK2 Gene

Aliases for ADCK2 Gene

  • AarF Domain Containing Kinase 2 2 3 5
  • AARF 3 4
  • Uncharacterized AarF Domain-Containing Protein Kinase 2 3
  • Putative Ubiquinone Biosynthesis Protein AarF 3
  • EC 2.7.11.- 4

External Ids for ADCK2 Gene

Previous GeneCards Identifiers for ADCK2 Gene

  • GC07P139703
  • GC07P139780
  • GC07P139826
  • GC07P140019
  • GC07P140372
  • GC07P134668

Summaries for ADCK2 Gene

GeneCards Summary for ADCK2 Gene

ADCK2 (AarF Domain Containing Kinase 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for ADCK2 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Additional gene information for ADCK2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK2 Gene

Genomics for ADCK2 Gene

Regulatory Elements for ADCK2 Gene

Enhancers for ADCK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H140672 1.6 FANTOM5 Ensembl ENCODE 20.7 +1.7 1686 4 HDGF PKNOX1 ARNT SIN3A FEZF1 DMAP1 ZNF766 CBX5 ZNF207 SP3 ADCK2 BRAF SLC37A3 KDM7A DENND2A NDUFB2
GH07H140621 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12 -47.5 -47526 8 FOXA2 PKNOX1 SIN3A FEZF1 ZNF2 ZNF121 GLIS2 FOS YY2 REST DENND2A ADCK2 NDUFB2 TMEM178B GC07P140619 LOC105375535
GH07H140655 1 Ensembl ENCODE 16.9 -16.3 -16325 1 IRF2 CEBPG BATF RAD21 RELA GATA3 CTBP1 EED SCRT2 ATF7 ADCK2 TMEM178B RN7SL771P
GH07H140923 1.4 ENCODE dbSUPER 8.6 +251.7 251699 2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 ZNF143 NDUFB2 MRPS33 NDUFB2-AS1 ADCK2 BRAF RNU6-85P
GH07H140637 1.2 ENCODE dbSUPER 8.2 -33.1 -33086 5 HDGF GLI4 ZNF2 GLIS2 ZNF416 KLF7 ATF7 YY2 ZNF488 ZFP41 CCT4P1 RNU4-74P SLC37A3 NDUFB2 NDUFB2-AS1 BRAF PARP12 ADCK2 TMEM178B LOC105375535
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADCK2 on UCSC Golden Path with GeneCards custom track

Promoters for ADCK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000219128 175 1401 ATF1 ARNT SIN3A DMAP1 GLI4 ZNF766 GLIS2 ATF7 SP3 YY2

Genomic Location for ADCK2 Gene

Chromosome:
7
Start:
140,672,925 bp from pter
End:
140,696,261 bp from pter
Size:
23,337 bases
Orientation:
Plus strand

Genomic View for ADCK2 Gene

Genes around ADCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK2 Gene

Proteins for ADCK2 Gene

  • Protein details for ADCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z695-ADCK2_HUMAN
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 2
    Protein Accession:
    Q7Z695
    Secondary Accessions:
    • Q96CN6
    • Q9Y6T5

    Protein attributes for ADCK2 Gene

    Size:
    626 amino acids
    Molecular mass:
    68982 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14107.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ADCK2 Gene

Post-translational modifications for ADCK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK2 Gene

No data available for DME Specific Peptides for ADCK2 Gene

Domains & Families for ADCK2 Gene

Gene Families for ADCK2 Gene

IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ADCK2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADCK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z695

UniProtKB/Swiss-Prot:

ADCK2_HUMAN :
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
Family:
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK2: view

Function for ADCK2 Gene

Molecular function for ADCK2 Gene

UniProtKB/Swiss-Prot Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Enzyme Numbers (IUBMB) for ADCK2 Gene

Gene Ontology (GO) - Molecular Function for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with ADCK2: view
genes like me logo Genes that share phenotypes with ADCK2: view

Animal Models for ADCK2 Gene

MGI Knock Outs for ADCK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCK2

CRISPR Products

miRNA for ADCK2 Gene

miRTarBase miRNAs that target ADCK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADCK2
  • Applied Biological Materials Clones for ADCK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCK2 Gene

Localization for ADCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADCK2 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCK2: view

Pathways & Interactions for ADCK2 Gene

SuperPathways for ADCK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with ADCK2: view

No data available for Pathways by source and SIGNOR curated interactions for ADCK2 Gene

Drugs & Compounds for ADCK2 Gene

No Compound Related Data Available

Transcripts for ADCK2 Gene

Unigene Clusters for ADCK2 Gene

AarF domain containing kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADCK2
  • Applied Biological Materials Clones for ADCK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK2 Gene

No ASD Table

Relevant External Links for ADCK2 Gene

GeneLoc Exon Structure for
ADCK2
ECgene alternative splicing isoforms for
ADCK2

Expression for ADCK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADCK2 Gene

Protein differential expression in normal tissues from HIPED for ADCK2 Gene

This gene is overexpressed in Heart (55.5) and Peripheral blood mononuclear cells (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADCK2 Gene



Protein tissue co-expression partners for ADCK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADCK2 Gene:

ADCK2

SOURCE GeneReport for Unigene cluster for ADCK2 Gene:

Hs.744886

Evidence on tissue expression from TISSUES for ADCK2 Gene

  • Muscle(4.2)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with ADCK2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADCK2 Gene

Orthologs for ADCK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADCK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCK2 33 34
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia ADCK2 33 34
  • 83.82 (n)
cow
(Bos Taurus)
Mammalia ADCK2 33 34
  • 81.99 (n)
mouse
(Mus musculus)
Mammalia Adck2 33 16 34
  • 78.25 (n)
rat
(Rattus norvegicus)
Mammalia Adck2 33
  • 77.89 (n)
oppossum
(Monodelphis domestica)
Mammalia ADCK2 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCK2 33 34
  • 65.45 (n)
lizard
(Anolis carolinensis)
Reptilia ADCK2 34
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adck2 33
  • 61.3 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC572087 33
  • 60.19 (n)
ADCK2 34
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.7 33 34
  • 48.26 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR222W 33
  • 47.69 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPL109C 33
  • 46.11 (n)
-- 34
  • 28 (a)
OneToOne
-- 36
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24795g 33
  • 45.87 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU05600 33
  • 47.58 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21C3.03 33
  • 46.43 (n)
Species where no ortholog for ADCK2 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCK2 Gene

ENSEMBL:
Gene Tree for ADCK2 (if available)
TreeFam:
Gene Tree for ADCK2 (if available)

Paralogs for ADCK2 Gene

No data available for Paralogs for ADCK2 Gene

Variants for ADCK2 Gene

Sequence variations from dbSNP and Humsavar for ADCK2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000308372 -- 140,684,226(+) GTCTG(C/G)GGCAA intron-variant
rs1000345757 -- 140,690,438(+) CCTCA(A/C)GTGAT intron-variant
rs1000388316 -- 140,674,494(+) CCACA(A/T)CCTCT intron-variant
rs1000420817 -- 140,690,883(+) CACAG(A/G)GTGGT intron-variant
rs1000724997 -- 140,676,352(+) TTTCA(A/G)CAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCK2 Gene

Variant ID Type Subtype PubMed ID
nsv1119143 CNV deletion 24896259
nsv831157 CNV gain 17160897
nsv831158 CNV loss 17160897

Variation tolerance for ADCK2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.98; 94.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCK2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCK2 Gene

Disorders for ADCK2 Gene

Relevant External Links for ADCK2

Genetic Association Database (GAD)
ADCK2
Human Genome Epidemiology (HuGE) Navigator
ADCK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCK2

No disorders were found for ADCK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCK2 Gene

Publications for ADCK2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60

Products for ADCK2 Gene

  • Addgene plasmids for ADCK2

Sources for ADCK2 Gene

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