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Aliases for ADCK2 Gene

Aliases for ADCK2 Gene

  • AarF Domain Containing Kinase 2 2 3
  • AARF 3 4
  • Uncharacterized AarF Domain-Containing Protein Kinase 2 3
  • Putative Ubiquinone Biosynthesis Protein AarF 3
  • EC 2.7.11.- 4

External Ids for ADCK2 Gene

Previous GeneCards Identifiers for ADCK2 Gene

  • GC07P139703
  • GC07P139780
  • GC07P139826
  • GC07P140019
  • GC07P140372
  • GC07P134668

Summaries for ADCK2 Gene

GeneCards Summary for ADCK2 Gene

ADCK2 (AarF Domain Containing Kinase 2) is a Protein Coding gene. Diseases associated with ADCK2 include klippel-feil syndrome. GO annotations related to this gene include protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for ADCK2 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK2 Gene

Genomics for ADCK2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ADCK2 Gene

140,672,930 bp from pter
140,696,261 bp from pter
23,332 bases
Plus strand

Genomic View for ADCK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK2 Gene

Proteins for ADCK2 Gene

  • Protein details for ADCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 2
    Protein Accession:
    Secondary Accessions:
    • Q96CN6
    • Q9Y6T5

    Protein attributes for ADCK2 Gene

    626 amino acids
    Molecular mass:
    68982 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH14107.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ADCK2 Gene

Proteomics data for ADCK2 Gene at MOPED

Post-translational modifications for ADCK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK2 Gene

No data available for DME Specific Peptides for ADCK2 Gene

Domains for ADCK2 Gene

Gene Families for ADCK2 Gene

Protein Domains for ADCK2 Gene


Suggested Antigen Peptide Sequences for ADCK2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q7Z695
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK2: view

Function for ADCK2 Gene

Molecular function for ADCK2 Gene

UniProtKB/Swiss-Prot Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)

Enzyme Numbers (IUBMB) for ADCK2 Gene

Gene Ontology (GO) - Molecular Function for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with ADCK2: view
genes like me logo Genes that share phenotypes with ADCK2: view

Animal Model Products

CRISPR Products

miRNA for ADCK2 Gene

miRTarBase miRNAs that target ADCK2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCK2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADCK2 Gene

Localization for ADCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ADCK2 Gene COMPARTMENTS Subcellular localization image for ADCK2 gene
Compartment Confidence
plasma membrane 3
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ADCK2: view

Pathways for ADCK2 Gene

SuperPathways for ADCK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ADCK2: view

No data available for Pathways by source for ADCK2 Gene

Transcripts for ADCK2 Gene

Unigene Clusters for ADCK2 Gene

AarF domain containing kinase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCK2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ADCK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK2 Gene

No ASD Table

Relevant External Links for ADCK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCK2 Gene

mRNA expression in normal human tissues for ADCK2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADCK2 Gene

SOURCE GeneReport for Unigene cluster for ADCK2 Gene Hs.744886

genes like me logo Genes that share expressions with ADCK2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADCK2 Gene

Orthologs for ADCK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADCK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADCK2 35
  • 99.41 (n)
  • 98.88 (a)
ADCK2 36
  • 99 (a)
(Bos Taurus)
Mammalia ADCK2 35
  • 81.99 (n)
  • 78.94 (a)
ADCK2 36
  • 78 (a)
(Canis familiaris)
Mammalia ADCK2 35
  • 83.82 (n)
  • 80.55 (a)
ADCK2 36
  • 80 (a)
(Mus musculus)
Mammalia Adck2 35
  • 78.25 (n)
  • 75.69 (a)
Adck2 16
Adck2 36
  • 75 (a)
(Monodelphis domestica)
Mammalia ADCK2 36
  • 63 (a)
(Rattus norvegicus)
Mammalia Adck2 35
  • 77.89 (n)
  • 73.86 (a)
(Gallus gallus)
Aves ADCK2 35
  • 65.45 (n)
  • 61.88 (a)
ADCK2 36
  • 53 (a)
(Anolis carolinensis)
Reptilia ADCK2 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adck2 35
  • 61.3 (n)
  • 58.14 (a)
(Danio rerio)
Actinopterygii ADCK2 36
  • 51 (a)
LOC572087 35
  • 60.19 (n)
  • 56.99 (a)
(Caenorhabditis elegans)
Secernentea Y32H12A.7 35
  • 48.26 (n)
  • 40.6 (a)
Y32H12A.7 36
  • 32 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR222W 35
  • 47.69 (n)
  • 36.52 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 28 (a)
-- 38
YPL109C 35
  • 46.11 (n)
  • 37.88 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24795g 35
  • 45.87 (n)
  • 37.62 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU05600 35
  • 47.58 (n)
  • 37.05 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21C3.03 35
  • 46.43 (n)
  • 36.98 (a)
Species with no ortholog for ADCK2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCK2 Gene

Gene Tree for ADCK2 (if available)
Gene Tree for ADCK2 (if available)

Paralogs for ADCK2 Gene

No data available for Paralogs for ADCK2 Gene

Variants for ADCK2 Gene

Sequence variations from dbSNP and Humsavar for ADCK2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs269266 -- 140,678,748(+) AGATG(A/G)AGGGG intron-variant
rs269267 -- 140,672,499(+) ctaaa(C/T)catac upstream-variant-2KB
rs1140034 - 140,674,249(+) TCATC(C/T)CCGTG missense, reference
rs2364395 -- 140,677,229(+) atggc(A/G)aaaca intron-variant
rs2907950 -- 140,688,306(+) cccaa(A/G)gtgct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCK2 Gene

Variant ID Type Subtype PubMed ID
nsv831157 CNV Gain 17160897
nsv831158 CNV Loss 17160897

Relevant External Links for ADCK2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCK2 Gene

Disorders for ADCK2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ADCK2 Gene including...

Search for ADCK2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ADCK2 Gene

Relevant External Links for ADCK2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ADCK2: view

No data available for UniProtKB/Swiss-Prot for ADCK2 Gene

Publications for ADCK2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  4. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PMID: 15324660) Jin J. … Pawson T. (Curr. Biol. 2004) 3
  5. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PMID: 22118674) Altun M. … Kessler B.M. (Chem. Biol. 2011) 3

Products for ADCK2 Gene

  • Addgene plasmids for ADCK2

Sources for ADCK2 Gene

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