ADCK2 Gene
protein-coding GIFtS: 49
GCID: GC07P140372
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|
aarF domain containing kinase 2
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Aliases
for ADCK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| AarF Domain Containing Kinase 21 2 | | AARF2 3 | | MGC207271 | | Putative Ubiquinone Biosynthesis Protein AarF2 | | Uncharacterized AarF Domain-Containing Protein Kinase 22 | | EC 2.7.11.-3 |
Export aliases for ADCK2 gene to outside databasesPrevious GC identifers: GC07P139703 GC07P139780 GC07P139826 GC07P140019 GC07P134668 |
Summaries
for ADCK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ADCK2_HUMAN, Q7Z695Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and whattype of substrate it would phosphorylate (Ser, Thr or Tyr)
|
Genomic Views
for ADCK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADCK2 gene promoter:
COUP-TF1 AML1a COUP HNF-4alpha2 HNF-4alpha1 RORalpha1 PPAR-gamma1 COUP-TF STAT3 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADCK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADCK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q34 Ensembl cytogenetic band: 7q34 HGNC cytogenetic band: 7q34ADCK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07P140372: view genomic region
(about GC identifiers)
Start:
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140,372,953 bp from pter |
End:
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140,396,061 bp from pter |
Size:
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23,109 bases |
Orientation:
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plus strand |
1 alternative location:
| Chr7+,CRA_TCAG 139,711,129-139,733,084 |
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Proteins
for ADCK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADCK2_HUMAN, Q7Z695 (See
protein sequence)Recommended Name: Uncharacterized aarF domain-containing protein kinase 2 Size: 626 amino acids; 68982 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAH14107.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing;
Secondary accessions: Q96CN6 Q9Y6T5Explore the universe of human proteins at neXtProt for ADCK2: NX_Q7Z695
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z695
ADCK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_443085.2
ENSEMBL proteins: ENSP00000072869 ENSP00000420512 ENSP00000417367 ENSP00000420288
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ADCK2 for ontologies About GeneDecksing
ADCK2 Antibody Products:
Assay Products for ADCK2: |
Protein
Domains /
Families
for ADCK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADCK2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q7Z695ProtoNet protein and cluster: Q7Z695 1 Blocks protein family: IPB004147 ABC1 protein
UniProtKB/Swiss-Prot: ADCK2_HUMAN, Q7Z695Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase familySimilarity: Contains 1 protein kinase domain |
Function
for ADCK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADCK2_HUMAN, Q7Z695Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and whattype of substrate it would phosphorylate (Ser, Thr or Tyr)Enzyme Number (IUBMB): EC 2.7.11.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCK2 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004672 | protein kinase activity |
-- | -- | | GO:0004674 | protein serine/threonine kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
ADCK2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ADCK2:
|
Pathways & Interactions
for ADCK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADCK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/6 Interacting proteins for ADCK2 (Q7Z6953 ENSP000000728694) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
|
Drugs & Compounds
for ADCK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADCK2
Search CenterWatch for drugs/clinical trials and news about ADCK2
|
Transcripts
for ADCK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADCK2 gene: NM_052853.3 Unigene Cluster for ADCK2: AarF domain containing kinase 2 Hs.534141 [show with all ESTs]Unigene Representative Sequence: NM_0528535 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000072869(uc003vvy.1) ENST00000476491(uc003vvz.3) ENST00000483369
ENST00000498423 ENST00000473512
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADCK2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADCK2 (NM_052853) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADCK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCK2 |
Additional cDNA sequence: AF131745.1 AY302592.1 BC014107.2 7 DOTS entries: DT.100028444 DT.95264491 DT.95159620 DT.121078797 DT.100818170 DT.100818171 DT.456076 24/415 AceView cDNA sequences (see all 415): BU608811 BU732455 AI017674 CA425711 AI340073 AI625407 CR610566 CB110719 AA341428 AI279760 CB267348 AF067166 AI951871 BM511845 AF050639 F19165 AA593450 F21673 BE745459 F18891 NM_052853 CA430229 CB109485 BQ431052
GeneLoc Exon Structure
|
Expression
for ADCK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADCK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTTCCTCTG
About this image
See ADCK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADCK2
SOURCE GeneReport for Unigene cluster: Hs.534141
SABiosciences Custom PCR Arrays for ADCK2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADCK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADCK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADCK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADCK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCK2 |
Orthologs
for ADCK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for ADCK2 gene from 9/26 species (see all 26) About this table
ENSEMBL Gene Tree for ADCK2 (if available)
TreeFam Gene Tree for ADCK2 (if available) |
Paralogs
for ADCK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ADCK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADCK2 (140372953 - 140396061 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADCK2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADCK2 |
|
Disorders
/ Diseases
for ADCK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADCK2 for disorders About GeneDecksing
4  diseases for ADCK2: About MalaCardsklippel-feil syndrome arachnoid cysts arachnoiditis cholesteatoma
1 disease from the University of Copenhagen DISEASES database for ADCK2:Klippel-Feil syndrome Human Genome Epidemiology (HuGE) Navigator: ADCK2 (2 documents)
Export disorders for ADCK2 gene to outside databases
|
Publications
for ADCK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADCK2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ADCK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Activity-based chemical proteomics accelerates inhibi tor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (2007)
- Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PubMed id 15324660)1 Jin J....Pawson T. (2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1 Scherer S.W.... Tsui L.-C. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
|
External Searches for ADCK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADCK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADCK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADCK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADCK2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADCK2 gene:
Search GeneIP for patents involving ADCK2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADCK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADCK2 |
|  |  |  | | | | ThermoFisher Antibodies for ADCK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADCK2 |
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