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Aliases for ADCK2 Gene

Aliases for ADCK2 Gene

  • AarF Domain Containing Kinase 2 2 3 5
  • AARF 3 4
  • Putative Ubiquinone Biosynthesis Protein AarF 3
  • EC 2.7.11.- 4

External Ids for ADCK2 Gene

Previous GeneCards Identifiers for ADCK2 Gene

  • GC07P139703
  • GC07P139780
  • GC07P139826
  • GC07P140019
  • GC07P140372
  • GC07P134668

Summaries for ADCK2 Gene

GeneCards Summary for ADCK2 Gene

ADCK2 (AarF Domain Containing Kinase 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity.

UniProtKB/Swiss-Prot for ADCK2 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK2 Gene

Genomics for ADCK2 Gene

Regulatory Elements for ADCK2 Gene

Enhancers for ADCK2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADCK2 on UCSC Golden Path with GeneCards custom track

Promoters for ADCK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADCK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADCK2 Gene

Chromosome:
7
Start:
140,672,925 bp from pter
End:
140,696,261 bp from pter
Size:
23,337 bases
Orientation:
Plus strand

Genomic View for ADCK2 Gene

Genes around ADCK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK2 Gene

Proteins for ADCK2 Gene

  • Protein details for ADCK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z695-ADCK2_HUMAN
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 2
    Protein Accession:
    Q7Z695
    Secondary Accessions:
    • Q96CN6
    • Q9Y6T5

    Protein attributes for ADCK2 Gene

    Size:
    626 amino acids
    Molecular mass:
    68982 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14107.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

neXtProt entry for ADCK2 Gene

Proteomics data for ADCK2 Gene at MOPED

Post-translational modifications for ADCK2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK2 Gene

Antibody Products

  • Abcam antibodies for ADCK2
  • Santa Cruz Biotechnology (SCBT) Antibodies for ADCK2

No data available for DME Specific Peptides for ADCK2 Gene

Domains & Families for ADCK2 Gene

Gene Families for ADCK2 Gene

Protein Domains for ADCK2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADCK2 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z695

UniProtKB/Swiss-Prot:

ADCK2_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK2: view

Function for ADCK2 Gene

Molecular function for ADCK2 Gene

UniProtKB/Swiss-Prot Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Enzyme Numbers (IUBMB) for ADCK2 Gene

Gene Ontology (GO) - Molecular Function for ADCK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ADCK2: view
genes like me logo Genes that share phenotypes with ADCK2: view

Animal Models for ADCK2 Gene

MGI Knock Outs for ADCK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for ADCK2

miRNA for ADCK2 Gene

miRTarBase miRNAs that target ADCK2

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ADCK2 Gene

Localization for ADCK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCK2 Gene COMPARTMENTS Subcellular localization image for ADCK2 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 2
cytosol 2
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for ADCK2 Gene

Pathways & Interactions for ADCK2 Gene

SuperPathways for ADCK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADCK2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ADCK2 Gene

Drugs & Compounds for ADCK2 Gene

No Compound Related Data Available

Transcripts for ADCK2 Gene

Unigene Clusters for ADCK2 Gene

AarF domain containing kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK2 Gene

No ASD Table

Relevant External Links for ADCK2 Gene

GeneLoc Exon Structure for
ADCK2
ECgene alternative splicing isoforms for
ADCK2

Expression for ADCK2 Gene

mRNA expression in normal human tissues for ADCK2 Gene

Protein differential expression in normal tissues from HIPED for ADCK2 Gene

This gene is overexpressed in Heart (55.5) and Peripheral blood mononuclear cells (13.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADCK2 Gene



SOURCE GeneReport for Unigene cluster for ADCK2 Gene Hs.744886

genes like me logo Genes that share expression patterns with ADCK2: view

Protein tissue co-expression partners for ADCK2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADCK2 Gene

Orthologs for ADCK2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADCK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADCK2 35
  • 81.99 (n)
  • 78.94 (a)
ADCK2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCK2 35
  • 83.82 (n)
  • 80.55 (a)
ADCK2 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adck2 35
  • 78.25 (n)
  • 75.69 (a)
Adck2 16
Adck2 36
  • 75 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADCK2 35
  • 99.41 (n)
  • 98.88 (a)
ADCK2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adck2 35
  • 77.89 (n)
  • 73.86 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCK2 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADCK2 35
  • 65.45 (n)
  • 61.88 (a)
ADCK2 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCK2 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adck2 35
  • 61.3 (n)
  • 58.14 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC572087 35
  • 60.19 (n)
  • 56.99 (a)
ADCK2 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y32H12A.7 35
  • 48.26 (n)
  • 40.6 (a)
Y32H12A.7 36
  • 32 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR222W 35
  • 47.69 (n)
  • 36.52 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24795g 35
  • 45.87 (n)
  • 37.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPL109C 35
  • 46.11 (n)
  • 37.88 (a)
-- 36
  • 28 (a)
OneToOne
-- 38
bread mold
(Neurospora crassa)
Ascomycetes NCU05600 35
  • 47.58 (n)
  • 37.05 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21C3.03 35
  • 46.43 (n)
  • 36.98 (a)
Species with no ortholog for ADCK2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCK2 Gene

ENSEMBL:
Gene Tree for ADCK2 (if available)
TreeFam:
Gene Tree for ADCK2 (if available)

Paralogs for ADCK2 Gene

No data available for Paralogs for ADCK2 Gene

Variants for ADCK2 Gene

Sequence variations from dbSNP and Humsavar for ADCK2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1140034 - 140,674,249(+) TCATC(C/T)CCGTG reference, missense
rs3748092 -, - 140,681,084(-) TTCCC(A/C/G/T)TGGAC intron-variant, reference, missense
VAR_029994 -
VAR_041419 -
rs2968558 - 140,673,526(-) CCGAC(C/T)CAGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADCK2 Gene

Variant ID Type Subtype PubMed ID
nsv831157 CNV Gain 17160897
nsv831158 CNV Loss 17160897

Variation tolerance for ADCK2 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.98; 94.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADCK2 Gene

Disorders for ADCK2 Gene

Relevant External Links for ADCK2

Genetic Association Database (GAD)
ADCK2
Human Genome Epidemiology (HuGE) Navigator
ADCK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCK2

No disorders were found for ADCK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCK2 Gene

Publications for ADCK2 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. (PMID: 15324660) Jin J. … Pawson T. (Curr. Biol. 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3
  5. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3

Products for ADCK2 Gene

Sources for ADCK2 Gene

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