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Aliases for ADCK1 Gene

Aliases for ADCK1 Gene

  • AarF Domain Containing Kinase 1 2 3 5
  • EC 2.7.11.- 4
  • EC 2.7.11 63

External Ids for ADCK1 Gene

Previous GeneCards Identifiers for ADCK1 Gene

  • GC14P076256
  • GC14P077336
  • GC14P078266
  • GC14P058432

Summaries for ADCK1 Gene

GeneCards Summary for ADCK1 Gene

ADCK1 (AarF Domain Containing Kinase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is ADCK5.

UniProtKB/Swiss-Prot for ADCK1 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK1 Gene

Genomics for ADCK1 Gene

Regulatory Elements for ADCK1 Gene

Enhancers for ADCK1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADCK1 on UCSC Golden Path with GeneCards custom track

Promoters for ADCK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADCK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADCK1 Gene

77,800,065 bp from pter
77,935,012 bp from pter
134,948 bases
Plus strand

Genomic View for ADCK1 Gene

Genes around ADCK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK1 Gene

Proteins for ADCK1 Gene

  • Protein details for ADCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 1
    Protein Accession:
    Secondary Accessions:
    • B3KUD5
    • Q6PD65
    • Q9UIE6

    Protein attributes for ADCK1 Gene

    530 amino acids
    Molecular mass:
    60577 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAD62620.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62620.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADCK1 Gene


neXtProt entry for ADCK1 Gene

Proteomics data for ADCK1 Gene at MOPED

Selected DME Specific Peptides for ADCK1 Gene

Post-translational modifications for ADCK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK1 Gene

Domains & Families for ADCK1 Gene

Gene Families for ADCK1 Gene

Protein Domains for ADCK1 Gene


Suggested Antigen Peptide Sequences for ADCK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK1: view

Function for ADCK1 Gene

Molecular function for ADCK1 Gene

UniProtKB/Swiss-Prot Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Enzyme Numbers (IUBMB) for ADCK1 Gene

genes like me logo Genes that share phenotypes with ADCK1: view

Animal Model Products

miRNA for ADCK1 Gene

miRTarBase miRNAs that target ADCK1

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADCK1 Gene

Localization for ADCK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK1 Gene


Subcellular locations from

Jensen Localization Image for ADCK1 Gene COMPARTMENTS Subcellular localization image for ADCK1 gene
Compartment Confidence
mitochondrion 4
extracellular 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ADCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ADCK1: view

Pathways & Interactions for ADCK1 Gene

SuperPathways for ADCK1 Gene

No Data Available

Interacting Proteins for ADCK1 Gene

Gene Ontology (GO) - Biological Process for ADCK1 Gene


No data available for Pathways by source and SIGNOR curated interactions for ADCK1 Gene

Drugs & Compounds for ADCK1 Gene

No Compound Related Data Available

Transcripts for ADCK1 Gene

Unigene Clusters for ADCK1 Gene

AarF domain containing kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -

Relevant External Links for ADCK1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADCK1 Gene

mRNA expression in normal human tissues for ADCK1 Gene

Protein differential expression in normal tissues from HIPED for ADCK1 Gene

This gene is overexpressed in Breast (23.8) and Bone (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADCK1 Gene

SOURCE GeneReport for Unigene cluster for ADCK1 Gene Hs.413208

genes like me logo Genes that share expression patterns with ADCK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ADCK1 Gene

Orthologs for ADCK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADCK1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADCK1 35
  • 87.97 (n)
  • 88.1 (a)
ADCK1 36
  • 88 (a)
(Canis familiaris)
Mammalia ADCK1 35
  • 90.04 (n)
  • 92.53 (a)
ADCK1 36
  • 92 (a)
(Mus musculus)
Mammalia Adck1 35
  • 85.7 (n)
  • 88.51 (a)
Adck1 16
Adck1 36
  • 88 (a)
(Pan troglodytes)
Mammalia ADCK1 35
  • 99.24 (n)
  • 99.62 (a)
ADCK1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Adck1 35
  • 83.16 (n)
  • 85.6 (a)
(Monodelphis domestica)
Mammalia ADCK1 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
-- 36
  • 79 (a)
(Gallus gallus)
Aves ADCK1 35
  • 75.72 (n)
  • 77.73 (a)
ADCK1 36
  • 77 (a)
(Anolis carolinensis)
Reptilia ADCK1 36
  • 73 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia adck1 35
  • 63.33 (n)
  • 64.35 (a)
(Danio rerio)
Actinopterygii adck1 35
  • 68.84 (n)
  • 71.01 (a)
adck1 36
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012287 35
  • 57.89 (n)
  • 51.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3608 35
  • 54.96 (n)
  • 48.55 (a)
CG3608 36
  • 45 (a)
(Caenorhabditis elegans)
Secernentea CELE_D2023.6 35
  • 49.6 (n)
  • 44.8 (a)
D2023.6 36
  • 44 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR119C 35
  • 46.72 (n)
  • 36.07 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22946g 35
  • 43.38 (n)
  • 35.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLR253W 35
  • 46.52 (n)
  • 35.9 (a)
-- 36
  • 28 (a)
MCP2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATH9 35
  • 47.89 (n)
  • 41.97 (a)
(Oryza sativa)
Liliopsida Os03g0698350 35
  • 50.19 (n)
  • 44.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04259 35
  • 48.36 (n)
  • 37.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC15C4.02 35
  • 45.31 (n)
  • 37.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5733 36
  • 51 (a)
Species with no ortholog for ADCK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCK1 Gene

Gene Tree for ADCK1 (if available)
Gene Tree for ADCK1 (if available)

Paralogs for ADCK1 Gene

Paralogs for ADCK1 Gene

genes like me logo Genes that share paralogs with ADCK1: view

Variants for ADCK1 Gene

Sequence variations from dbSNP and Humsavar for ADCK1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7140153 -- 77,860,942(+) GGGAG(A/G)GAGGT intron-variant
rs1469018 -- 77,811,750(+) GCTGC(A/G)GTGAG intron-variant
rs7141447 -- 77,878,804(+) CTGAA(A/G)GATTA intron-variant
rs7141578 -- 77,928,130(+) gtagg(A/G)ttgga intron-variant
rs7401295 -- 77,820,529(+) gtttc(A/G)ctatg intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ADCK1 Gene

Variant ID Type Subtype PubMed ID
nsv1363 CNV Insertion 18451855
esv2748906 CNV Deletion 23290073
esv2677599 CNV Deletion 23128226
esv24205 CNV Loss 19812545
nsv827001 CNV Loss 20364138
esv34345 CNV Loss 17911159
dgv644e1 CNV Complex 17122850
nsv456345 CNV Loss 19166990
nsv515961 CNV Loss 19592680

Variation tolerance for ADCK1 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.64% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADCK1 Gene

Disorders for ADCK1 Gene

Relevant External Links for ADCK1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADCK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCK1 Gene

Publications for ADCK1 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48 67
  2. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. (PMID: 24554482) Leger P.D. … Haas D.W. (J. Neurovirol. 2014) 3

Products for ADCK1 Gene

Sources for ADCK1 Gene