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Aliases for ADCK1 Gene

Aliases for ADCK1 Gene

  • AarF Domain Containing Kinase 1 2 3
  • EC 2.7.11.- 4
  • EC 2.7.11 63

External Ids for ADCK1 Gene

Previous GeneCards Identifiers for ADCK1 Gene

  • GC14P076256
  • GC14P077336
  • GC14P078266
  • GC14P058432

Summaries for ADCK1 Gene

GeneCards Summary for ADCK1 Gene

ADCK1 (AarF Domain Containing Kinase 1) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is ADCK5.

UniProtKB/Swiss-Prot for ADCK1 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK1 Gene

Genomics for ADCK1 Gene

Regulatory Elements for ADCK1 Gene

Genomic Location for ADCK1 Gene

Start:
77,800,083 bp from pter
End:
77,935,012 bp from pter
Size:
134,930 bases
Orientation:
Plus strand

Genomic View for ADCK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK1 Gene

Proteins for ADCK1 Gene

  • Protein details for ADCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TW2-ADCK1_HUMAN
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 1
    Protein Accession:
    Q86TW2
    Secondary Accessions:
    • B3KUD5
    • Q6PD65
    • Q9UIE6

    Protein attributes for ADCK1 Gene

    Size:
    530 amino acids
    Molecular mass:
    60577 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62620.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62620.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADCK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCK1 Gene

Proteomics data for ADCK1 Gene at MOPED

Selected DME Specific Peptides for ADCK1 Gene

Post-translational modifications for ADCK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK1 Gene

Domains for ADCK1 Gene

Gene Families for ADCK1 Gene

Protein Domains for ADCK1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADCK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TW2

UniProtKB/Swiss-Prot:

ADCK1_HUMAN :
  • Q86TW2
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK1: view

Function for ADCK1 Gene

Molecular function for ADCK1 Gene

UniProtKB/Swiss-Prot Function: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr)

Enzyme Numbers (IUBMB) for ADCK1 Gene

Gene Ontology (GO) - Molecular Function for ADCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with ADCK1: view

Phenotypes for ADCK1 Gene

GenomeRNAi human phenotypes for ADCK1:
genes like me logo Genes that share phenotypes with ADCK1: view

Animal Model Products

CRISPR Products

miRNA for ADCK1 Gene

miRTarBase miRNAs that target ADCK1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCK1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ADCK1 Gene

Localization for ADCK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCK1 Gene COMPARTMENTS Subcellular localization image for ADCK1 gene
Compartment Confidence
extracellular 3
mitochondrion 3
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ADCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ADCK1: view

Pathways for ADCK1 Gene

SuperPathways for ADCK1 Gene

No Data Available

Interacting Proteins for ADCK1 Gene

Gene Ontology (GO) - Biological Process for ADCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ADCK1: view

No data available for Pathways by source for ADCK1 Gene

Transcripts for ADCK1 Gene

Unigene Clusters for ADCK1 Gene

AarF domain containing kinase 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADCK1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5:
SP6:

Relevant External Links for ADCK1 Gene

GeneLoc Exon Structure for
ADCK1
ECgene alternative splicing isoforms for
ADCK1

Expression for ADCK1 Gene

mRNA expression in normal human tissues for ADCK1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADCK1 Gene

SOURCE GeneReport for Unigene cluster for ADCK1 Gene Hs.413208

genes like me logo Genes that share expressions with ADCK1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADCK1 Gene

Orthologs for ADCK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADCK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADCK1 35
  • 99.24 (n)
  • 99.62 (a)
ADCK1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADCK1 35
  • 87.97 (n)
  • 88.1 (a)
ADCK1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCK1 35
  • 90.04 (n)
  • 92.53 (a)
ADCK1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adck1 35
  • 85.7 (n)
  • 88.51 (a)
Adck1 16
Adck1 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADCK1 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Adck1 35
  • 83.16 (n)
  • 85.6 (a)
chicken
(Gallus gallus)
Aves ADCK1 35
  • 75.72 (n)
  • 77.73 (a)
ADCK1 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCK1 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adck1 35
  • 63.33 (n)
  • 64.35 (a)
zebrafish
(Danio rerio)
Actinopterygii adck1 35
  • 68.84 (n)
  • 71.01 (a)
adck1 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012287 35
  • 57.89 (n)
  • 51.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3608 35
  • 54.96 (n)
  • 48.55 (a)
CG3608 36
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_D2023.6 35
  • 49.6 (n)
  • 44.8 (a)
D2023.6 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR119C 35
  • 46.72 (n)
  • 36.07 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 28 (a)
OneToMany
-- 38
YLR253W 35
  • 46.52 (n)
  • 35.9 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22946g 35
  • 43.38 (n)
  • 35.26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATH9 35
  • 47.89 (n)
  • 41.97 (a)
rice
(Oryza sativa)
Liliopsida Os03g0698350 35
  • 50.19 (n)
  • 44.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04259 35
  • 48.36 (n)
  • 37.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC15C4.02 35
  • 45.31 (n)
  • 37.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5733 36
  • 51 (a)
OneToOne
Species with no ortholog for ADCK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCK1 Gene

ENSEMBL:
Gene Tree for ADCK1 (if available)
TreeFam:
Gene Tree for ADCK1 (if available)

Paralogs for ADCK1 Gene

Paralogs for ADCK1 Gene

genes like me logo Genes that share paralogs with ADCK1: view

Variants for ADCK1 Gene

Sequence variations from dbSNP and Humsavar for ADCK1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2364 -- 77,892,114(+) CTGTT(A/G)TACAC intron-variant
rs719049 -- 77,836,594(-) agaaa(G/T)gtagg intron-variant
rs719050 -- 77,836,735(-) GCTTA(A/G)ATTGC intron-variant
rs724263 -- 77,855,531(+) ACTCT(G/T)TTAAT intron-variant
rs724264 -- 77,855,467(+) TCCTG(C/T)GTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCK1 Gene

Variant ID Type Subtype PubMed ID
nsv1363 CNV Insertion 18451855
esv2748906 CNV Deletion 23290073
esv2677599 CNV Deletion 23128226
esv24205 CNV Loss 19812545
nsv827001 CNV Loss 20364138
esv34345 CNV Loss 17911159
dgv644e1 CNV Complex 17122850
nsv456345 CNV Loss 19166990
nsv515961 CNV Loss 19592680

Relevant External Links for ADCK1 Gene

HapMap Linkage Disequilibrium report
ADCK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCK1 Gene

Disorders for ADCK1 Gene

Relevant External Links for ADCK1

Genetic Association Database (GAD)
ADCK1
Human Genome Epidemiology (HuGE) Navigator
ADCK1
genes like me logo Genes that share disorders with ADCK1: view

No data available for UniProtKB/Swiss-Prot for ADCK1 Gene

Publications for ADCK1 Gene

  1. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for ADCK1 Gene

  • Addgene plasmids for ADCK1

Sources for ADCK1 Gene

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