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Aliases for ADCK1 Gene

Aliases for ADCK1 Gene

  • AarF Domain Containing Kinase 1 2 3 5
  • EC 2.7.11.- 4
  • EC 2.7.11 61

External Ids for ADCK1 Gene

Previous GeneCards Identifiers for ADCK1 Gene

  • GC14P076256
  • GC14P077336
  • GC14P078266
  • GC14P058432

Summaries for ADCK1 Gene

GeneCards Summary for ADCK1 Gene

ADCK1 (AarF Domain Containing Kinase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein serine/threonine kinase activity. An important paralog of this gene is ADCK5.

UniProtKB/Swiss-Prot for ADCK1 Gene

  • The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADCK1 Gene

Genomics for ADCK1 Gene

Regulatory Elements for ADCK1 Gene

Enhancers for ADCK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ADCK1 on UCSC Golden Path with GeneCards custom track

Promoters for ADCK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ADCK1 Gene

Chromosome:
14
Start:
77,800,065 bp from pter
End:
77,935,012 bp from pter
Size:
134,948 bases
Orientation:
Plus strand

Genomic View for ADCK1 Gene

Genes around ADCK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADCK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADCK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADCK1 Gene

Proteins for ADCK1 Gene

  • Protein details for ADCK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86TW2-ADCK1_HUMAN
    Recommended name:
    Uncharacterized aarF domain-containing protein kinase 1
    Protein Accession:
    Q86TW2
    Secondary Accessions:
    • B3KUD5
    • Q6PD65
    • Q9UIE6

    Protein attributes for ADCK1 Gene

    Size:
    530 amino acids
    Molecular mass:
    60577 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62620.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62620.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305};

    Alternative splice isoforms for ADCK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADCK1 Gene

Selected DME Specific Peptides for ADCK1 Gene

Post-translational modifications for ADCK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADCK1 Gene

Domains & Families for ADCK1 Gene

Gene Families for ADCK1 Gene

Protein Domains for ADCK1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADCK1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86TW2

UniProtKB/Swiss-Prot:

ADCK1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. ADCK protein kinase family.
genes like me logo Genes that share domains with ADCK1: view

Function for ADCK1 Gene

Molecular function for ADCK1 Gene

UniProtKB/Swiss-Prot Function:
The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr).

Enzyme Numbers (IUBMB) for ADCK1 Gene

Gene Ontology (GO) - Molecular Function for ADCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with ADCK1: view
genes like me logo Genes that share phenotypes with ADCK1: view

Animal Model Products

CRISPR Products

miRNA for ADCK1 Gene

miRTarBase miRNAs that target ADCK1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADCK1

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADCK1 Gene

Localization for ADCK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADCK1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADCK1 Gene COMPARTMENTS Subcellular localization image for ADCK1 gene
Compartment Confidence
mitochondrion 4
extracellular 3
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for ADCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ADCK1: view

Pathways & Interactions for ADCK1 Gene

SuperPathways for ADCK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADCK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with ADCK1: view

No data available for Pathways by source and SIGNOR curated interactions for ADCK1 Gene

Drugs & Compounds for ADCK1 Gene

No Compound Related Data Available

Transcripts for ADCK1 Gene

Unigene Clusters for ADCK1 Gene

AarF domain containing kinase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ADCK1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADCK1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - -
SP5:
SP6:

Relevant External Links for ADCK1 Gene

GeneLoc Exon Structure for
ADCK1
ECgene alternative splicing isoforms for
ADCK1

Expression for ADCK1 Gene

mRNA expression in normal human tissues for ADCK1 Gene

Protein differential expression in normal tissues from HIPED for ADCK1 Gene

This gene is overexpressed in Breast (23.8) and Bone (19.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADCK1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ADCK1 Gene:

ADCK1

SOURCE GeneReport for Unigene cluster for ADCK1 Gene:

Hs.413208
genes like me logo Genes that share expression patterns with ADCK1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ADCK1 Gene

Orthologs for ADCK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADCK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADCK1 34
  • 87.97 (n)
  • 88.1 (a)
ADCK1 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADCK1 34
  • 90.04 (n)
  • 92.53 (a)
ADCK1 35
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adck1 34
  • 85.7 (n)
  • 88.51 (a)
Adck1 16
Adck1 35
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADCK1 34
  • 99.24 (n)
  • 99.62 (a)
ADCK1 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adck1 34
  • 83.16 (n)
  • 85.6 (a)
oppossum
(Monodelphis domestica)
Mammalia ADCK1 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves ADCK1 34
  • 75.72 (n)
  • 77.73 (a)
ADCK1 35
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADCK1 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adck1 34
  • 63.33 (n)
  • 64.35 (a)
zebrafish
(Danio rerio)
Actinopterygii adck1 34
  • 68.84 (n)
  • 71.01 (a)
adck1 35
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012287 34
  • 57.89 (n)
  • 51.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3608 34
  • 54.96 (n)
  • 48.55 (a)
CG3608 35
  • 45 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_D2023.6 34
  • 49.6 (n)
  • 44.8 (a)
D2023.6 35
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR119C 34
  • 46.72 (n)
  • 36.07 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F22946g 34
  • 43.38 (n)
  • 35.26 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YLR253W 34
  • 46.52 (n)
  • 35.9 (a)
-- 35
  • 28 (a)
OneToMany
MCP2 37
thale cress
(Arabidopsis thaliana)
eudicotyledons ATH9 34
  • 47.89 (n)
  • 41.97 (a)
rice
(Oryza sativa)
Liliopsida Os03g0698350 34
  • 50.19 (n)
  • 44.03 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04259 34
  • 48.36 (n)
  • 37.56 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC15C4.02 34
  • 45.31 (n)
  • 37.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5733 35
  • 51 (a)
OneToOne
Species where no ortholog for ADCK1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADCK1 Gene

ENSEMBL:
Gene Tree for ADCK1 (if available)
TreeFam:
Gene Tree for ADCK1 (if available)

Paralogs for ADCK1 Gene

Paralogs for ADCK1 Gene

genes like me logo Genes that share paralogs with ADCK1: view

Variants for ADCK1 Gene

Sequence variations from dbSNP and Humsavar for ADCK1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1469018 -- 77,811,750(+) GCTGC(A/G)GTGAG intron-variant
rs1549118 -- 77,913,341(+) CCAGG(C/T)CCGAG intron-variant, utr-variant-5-prime
rs2364 -- 77,892,114(+) CTGTT(A/G)TACAC intron-variant
rs7141447 -- 77,878,804(+) CTGAA(A/G)GATTA intron-variant
rs7141578 -- 77,928,130(+) gtagg(A/G)ttgga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADCK1 Gene

Variant ID Type Subtype PubMed ID
dgv3782n54 CNV loss 21841781
dgv3783n54 CNV loss 21841781
dgv3784n54 CNV loss 21841781
dgv3785n54 CNV loss 21841781
dgv3786n54 CNV loss 21841781
dgv410e214 CNV loss 21293372
esv24205 CNV loss 19812545
esv2677599 CNV deletion 23128226
esv2748906 CNV deletion 23290073
esv2759999 CNV loss 17122850
esv34345 CNV loss 17911159
esv3551816 CNV deletion 23714750
esv3581318 CNV loss 25503493
esv3635015 CNV loss 21293372
esv3635016 CNV loss 21293372
esv3635017 CNV loss 21293372
esv3635020 CNV gain 21293372
esv3635021 CNV loss 21293372
esv3635022 CNV gain 21293372
nsv1116037 CNV deletion 24896259
nsv1363 CNV insertion 18451855
nsv456345 CNV loss 19166990
nsv472932 CNV novel sequence insertion 20440878
nsv515961 CNV loss 19592680
nsv565223 CNV gain+loss 21841781
nsv565233 CNV loss 21841781
nsv565234 CNV loss 21841781
nsv827001 CNV loss 20364138

Variation tolerance for ADCK1 Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.27; 40.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADCK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADCK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADCK1 Gene

Disorders for ADCK1 Gene

Relevant External Links for ADCK1

Genetic Association Database (GAD)
ADCK1
Human Genome Epidemiology (HuGE) Navigator
ADCK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADCK1

No disorders were found for ADCK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADCK1 Gene

Publications for ADCK1 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 2 3 65
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 65

Products for ADCK1 Gene

Sources for ADCK1 Gene

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