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ADC Gene

protein-coding   GIFtS: 60
GCID: GC01P033546

Arginine Decarboxylase

  Search for ADC
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arginine Decarboxylase1 2     AZI22
Ornithine Decarboxylase Like1 2     Antizyme Inhibitor 22
Ornithine Decarboxylase-Like Protein2 3     ODC Antizyme Inhibitor-22
ARGDC2 3     Ornithine Decarboxylase-Paralog2
ODC-p2 3     EC 4.1.1.193
ODC-paralogue2 3     ODCP3
ODC1L2 5     AZIN25
KIAA19453 5     

External Ids:    HGNC: 299571   Entrez Gene: 1134512   Ensembl: ENSG000001429207   OMIM: 6083535   UniProtKB: Q96A703   

Export aliases for ADC gene to outside databases

Previous GC identifers: GC01P033216 GC01P033319 GC01P031663


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ADC Gene:
ADC (arginine decarboxylase) is a protein-coding gene. GO annotations related to this gene include ornithine decarboxylase activator activity and arginine decarboxylase activity. An important paralog of this gene is ODC1.

UniProtKB/Swiss-Prot: ADC_HUMAN, Q96A70
Function: Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity

Gene Wiki entry for ADC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADC gene promoter:
         c-Fos   AP-1   CUTL1   C/EBPalpha   CHOP-10   E2F-1   E2F   c-Jun   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADC promoter sequence
   Search Chromatin IP Primers for ADC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

ADC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P033546:  view genomic region     (about GC identifiers)

Start:
33,546,705 bp from pter      End:
33,586,131 bp from pter
Size:
39,427 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ADC_HUMAN, Q96A70 (See protein sequence)
Recommended Name: Arginine decarboxylase  
Size: 460 amino acids; 49980 Da
Cofactor: Pyridoxal phosphate (By similarity)
Secondary accessions: B2RDU5 D3DPQ9 Q5TIF4 Q5TIF5 Q5TIF6 Q8TF56 Q96L54 Q96L55 Q96L56 Q96L57
Q96MD9
Alternative splicing: 5 isoforms:  Q96A70-1   Q96A70-2   Q96A70-3   Q96A70-4   Q96A70-5   

Explore the universe of human proteins at neXtProt for ADC: NX_Q96A70

Explore proteomics data for ADC at MOPED


See ADC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_443724.1  
ENSEMBL proteins: 
 ENSP00000294517   ENSP00000362542   ENSP00000362539   ENSP00000362540   ENSP00000381233  
 ENSP00000351508  
Reactome Protein details: Q96A70

ADC Human Recombinant Protein Products:

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ADC Antibody Products:

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LSBio Antibodies in human, mouse, rat for ADC

ADC Assay Products:

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Cloud-Clone Corp. ELISAs for ADC
Cloud-Clone Corp. CLIAs for ADC
Search eBioscience for ELISAs for ADC 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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IUPHAR Guide to PHARMACOLOGY protein family classification: L-Arginine decarboxylase
Decarboxylases

Selected InterPro protein domains (see all 7):
 IPR009006 Ala_racemase/Decarboxylase_C
 IPR000183 Orn/DAP/Arg_de-COase
 IPR022657 De-COase2_CS
 IPR002433 Orn_de-COase
 IPR022644 De-COase2_N

Graphical View of Domain Structure for InterPro Entry Q96A70

ProtoNet protein and cluster: Q96A70

2 Blocks protein domains:
IPB000183 Orn/DAP/Arg decarboxylase
IPB002433 Ornithine decarboxylase signature


UniProtKB/Swiss-Prot: ADC_HUMAN, Q96A70
Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family


Find genes that share domains with ADC           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: ADC_HUMAN, Q96A70
Function: Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity
Catalytic activity: L-arginine = agmatine + CO(2)

     Enzyme Number (IUBMB): EC 4.1.1.191

     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0005515protein binding ----
GO:0008792arginine decarboxylase activity IEA--
GO:0042978ornithine decarboxylase activator activity IEA--
     
Find genes that share ontologies with ADC           About GenesLikeMe


Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADC
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miRNA
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miRTarBase miRNAs that target ADC:
hsa-mir-30d-5p (MIRT047794), hsa-mir-151a-3p (MIRT043607)

Block miRNA regulation of human, mouse, rat ADC using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate ADC:
hsa-miR-153 hsa-miR-448
SwitchGear 3'UTR luciferase reporter plasmidADC 3' UTR sequence
Inhib. RNA
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OriGene RNAi products in human, mouse, rat for ADC
Predesigned siRNA for gene silencing in human, mouse, rat ADC

Gene Editing
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Sino Biological Human cDNA Clone for ADC
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADC

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADC


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
mitochondrion2
nucleus2
plasma membrane2
cytoskeleton1
extracellular1

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IEA--
GO:0005829cytosol TAS--

Find genes that share ontologies with ADC           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ADC About    
See pathways by source

SuperPathContained pathways About
1Metabolism of amino acids and derivatives
Metabolism of amino acids and derivatives
putrescine biosynthesis III0.00
Metabolism of polyamines0.00
Agmatine biosynthesis0.00
2Metabolism
Metabolism0.38
Metabolic pathways0.38
3Arginine and proline metabolism
Arginine and proline metabolism


Find genes that share SuperPaths with ADC           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for ADC
    putrescine biosynthesis III


1 Reactome Pathway for ADC
    Agmatine biosynthesis


2 Kegg Pathways  (Kegg details for ADC):
    Arginine and proline metabolism
Metabolic pathways

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADC
Interactions:

    Search GeneGlobe Interaction Network for ADC

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

Selected Interacting proteins for ADC (ENSP000002945174) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
InteractantInteraction Details
GeneCardExternal ID(s)
AGMATENSP000003649864STRING: ENSP00000364986
ARG1ENSP000003570664STRING: ENSP00000357066
ARG2ENSP000002617834STRING: ENSP00000261783
ASLENSP000003071884STRING: ENSP00000307188
NOS1ENSP000003207584STRING: ENSP00000320758
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006591ornithine metabolic process IEA--
GO:0006595polyamine metabolic process TAS--
GO:0006596polyamine biosynthetic process IEA--
GO:0007283spermatogenesis NAS11587527
GO:0034641cellular nitrogen compound metabolic process TAS--

Find genes that share ontologies with ADC           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for ADC

8 HMDB Compounds for ADC    About this table
CompoundSynonyms CAS #PubMed Ids
Agmatine(4-Aminobutyl)guanidine (see all 11)306-60-5--
Carbon dioxideCarbon oxide (see all 5)124-38-9--
FamotidineAmfamox (see all 83)76824-35-6--
Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--
Guanidine(4-Aminobutyl) guanidine (see all 8)50-01-1--
L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

2 DrugBank Compounds for ADC    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor11168717 11980912 15583399 16997906 17305368
L-Arginine(S)-2-Amino-5-guanidinovaleric acid (see all 4)74-79-3target--17287563 17653850 16703907 17025265

Selected Novoseek inferred chemical compound relationships for ADC gene (see all 20)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
agmatine 94.6 34 14738999 (3), 9494113 (1), 9851555 (1), 15465778 (1) (see all 21)
putrescine 84.1 19 14684170 (2), 9494113 (1), 14763899 (1), 11537482 (1) (see all 11)
ornithine 81.3 12 17900240 (1), 9753623 (1), 10691775 (1), 16997906 (1) (see all 10)
arginine 81 131 8300600 (5), 17900240 (2), 8181483 (2), 15028566 (2) (see all 52)
diaminopimelate 73.9 2 8181483 (1)
spermine 65.7 5 10853267 (1), 11683273 (1), 16511187 (1), 7698471 (1)
spermidine 60.7 2 10853267 (1), 16511187 (1)
nitric oxide 49.1 14 7532730 (2), 9806879 (1), 15465778 (1), 17287563 (1) (see all 9)
amine 46.1 7 9494113 (1), 15028566 (1), 17653850 (1), 14738999 (1) (see all 5)
proline 34.7 2 15465778 (1), 8954792 (1)



Find genes that share compounds with ADC           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ADC gene: 
NM_052998.2  

Unigene Cluster for ADC:

Arginine decarboxylase
Hs.101807  [show with all ESTs]
Unigene Representative Sequence: AL832640
Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
ENST00000478635 ENST00000294517(uc001bwr.3 uc001bws.3 uc009vue.3)
ENST00000481886(uc001bwu.3 uc001bwv.3) ENST00000475935(uc001bwt.1)
ENST00000462920 ENST00000471119 ENST00000495135 ENST00000477570 ENST00000483027
ENST00000492420 ENST00000373443(uc001bwy.1 uc001bwz.1) ENST00000497710
ENST00000473089 ENST00000484656(uc001bwx.1) ENST00000373440 ENST00000373441
ENST00000478204 ENST00000497280
miRNA
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Block miRNA regulation of human, mouse, rat ADC using miScript Target Protectors
2 qRT-PCR Assays for microRNAs that regulate ADC:
hsa-miR-153 hsa-miR-448
SwitchGear 3'UTR luciferase reporter plasmidADC 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for ADC
Predesigned siRNA for gene silencing in human, mouse, rat ADC
Clone
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript Custom all cDNA clones Services for ADC
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADC
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADC
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for ADC
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADC
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  QuantiFast Probe-based Assays in human, mouse, rat ADC

Additional mRNA sequence: 

AK057051.1 AK095127.1 AK122697.1 AK315677.1 AL832640.2 AY050634.1 AY050635.1 AY050636.1 
AY050637.1 AY050638.1 AY325129.1 BC010449.1 BC028128.1 

20 DOTS entries:

DT.92417781  DT.100024280  DT.411650  DT.121430699  DT.97788716  DT.100783614  DT.101983638  DT.121430748 
DT.40294281  DT.100783613  DT.40118336  DT.92040906  DT.95074863  DT.100783615  DT.100810798  DT.95074872 
DT.95079142  DT.121430766  DT.91760719  DT.91809954 

Selected AceView cDNA sequences (see all 84):

AL535454 BC028128 BM806760 BQ066847 Z41611 AI611040 H26992 AA719603 
N74336 AY050636 AK057051 AY050637 AI632488 CR593091 AY050638 AY050634 
AI097297 AK122697 AY325129 NM_052998 AB075825 BC010449 AW025653 AW450278 

GeneLoc Exon Structure

Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADC (see all 15)    About this scheme

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1:                                            -     -                       -                                   -           -                           
SP2:                    -     -                 -     -                       -                                   -           -                           
SP3:                    -     -     -     -     -     -                       -                                   -           -                           
SP4:                    -     -                                               -                                   -           -                           
SP5:                                            -     -                       -                                               -                           


ECgene alternative splicing isoforms for ADC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ADC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAGTGGGCC
ADC Expression
About this image


ADC expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Bone (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
 
 Cartilage (Muscoskeletal System)
         HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
 
 Eye (Sensory Organs)
         Lens
 
 Neural Tube (Nervous System)
         Telencephalon
 
 Brain (Nervous System)
         Striatum
ADC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ADC Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.101807

UniProtKB/Swiss-Prot: ADC_HUMAN, Q96A70
Tissue specificity: Highly expressed in brain. Also expressed in testis

    Custom PCR Arrays for ADC
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADC

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for ADC gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Adc1 , 5 arginine decarboxylase1, 5 87.51(n)1
86.27(a)1
  4 (62.48 cM)5
2426691  NM_172875.21  NP_766463.11 
 1289302335 
chicken
(Gallus gallus)
Aves ADC1 arginine decarboxylase 66.96(n)
58.64(a)
  428228  XM_004947849.1  XP_004947906.1 
lizard
(Anolis carolinensis)
Reptilia ADC6
arginine decarboxylase
63(a)
1 ↔ 1
GL343481.1(612315-621070)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.81282 Transcribed sequence with weak similarity to protein more 73.81(n)    BX736493.1 
fruit fly
(Drosophila melanogaster)
Insecta Odc16
Odc26
Ornithine decarboxylase 2
37(a)
35(a)
many ↔ many
many ↔ many
2R(3892308-3894177)
2R(3894769-3896567)
worm
(Caenorhabditis elegans)
Secernentea F53F10.26
Protein F53F10.2, isoform a
23(a)
1 → many
I(3831117-3834124) WBGene00018764
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPE16
Ornithine decarboxylase, catalyzes the first step ...
32(a)
1 → many
XI(96757-98157) YKL184W


ENSEMBL Gene Tree for ADC (if available)
TreeFam Gene Tree for ADC (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ADC gene
ODC12  AZIN12  
2 SIMAP similar genes for ADC using alignment to 3 protein entries:     ADC_HUMAN (see all proteins):
ODC1    AZIN1

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1 Pseudogenes.org Pseudogene for ADC
PGOHUM00000263037


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ADC (see all 891)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1169060031,2
C,F--33544855(+) TTATAT/CGTCCC 1 -- us2k11Minor allele frequency- C:0.08EA 120
rs796598141,2
C,F--33544893(+) TCCTGC/TTTCTG 1 -- us2k11Minor allele frequency- T:0.03NA 120
rs605277271,2
C,F--33544923(+) TGTGTA/GCTGAG 1 -- us2k12Minor allele frequency- G:0.07WA 120
rs1457285681,2
--33544974(+) AAGGCA/GGGACA 1 -- us2k10--------
rs358424481,2
C,F--33545024(+) GGGCAT/CGGTGG 1 -- us2k19Minor allele frequency- C:0.32NA WA CSA EA 370
rs1849865311,2
--33545025(+) GGCATA/GGTGGC 1 -- us2k10--------
rs1478520741,2
C--33545035(+) CTCACA/GCCTGT 1 -- us2k10--------
rs1413872331,2
--33545219(+) TTGAGC/GCTGGG 1 -- us2k10--------
rs107126761,2
C--33545304(+) AAGAG-/A/AA  
        
AAAAA
1 -- us2k1 trp31CSA 2
rs1146842581,2
F--33545354(+) ATATGG/ATAGAC 1 -- us2k11Minor allele frequency- A:0.01WA 118

HapMap Linkage Disequilibrium report for ADC (33546705 - 33586131 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for ADC:    About this table    
Variant IDTypeSubtypePubMed ID
nsv834602CNV Loss17160897

Human Gene Mutation Database (HGMD): ADC
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing ADC
DNA2.0 Custom Variant and Variant Library Synthesis for ADC

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 608353    OMIM disorders: --


Find genes that share disorders with ADC           About GenesLikeMe

2 Novoseek inferred disease relationships for ADC gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
inflammation 0 1 10431034 (1)
tumors 0 1 10431034 (1)

Genetic Association Database (GAD): ADC
Human Genome Epidemiology (HuGE) Navigator: ADC (21 documents)

Export disorders for ADC gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ADC gene, integrated from 10 sources (see all 74):
(articles sorted by number of sources associating them with ADC)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. (PubMed id 14738999)1, 2, 3, 9 Zhu M.-Y.... Regunathan S. (Biochim. Biophys. Acta 2004)
  2. Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes. (PubMed id 11587527)1, 2, 3, 9 Pitkaenen L.T.... Andersson L.C. (Biochem. Biophys. Res. Commun. 2001)
  3. Non-synonymous single-nucleotide polymorphisms associated with blood pressure and hypertension. (PubMed id 20147969)1, 4 Hong K.W....Oh B. (J Hum Hypertens 2010)
  4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  7. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (DNA Res. 2001)
  8. Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. (PubMed id 16916800)1, 9 LA^pez-Contreras A.J....PeA+afiel R. (J. Biol. Chem. 2006)
  9. Putrescine biosynthesis in mammalian tissues. (PubMed id 14763899)1, 9 Coleman C.S....Pegg A.E. (Biochem. J. 2004)
  10. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PubMed id 17900240)1, 9 Kanerva K....Andersson L.C. (Biochem. J. 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 113451 HGNC: 29957 AceView: ODC-p Ensembl:ENSG00000142920 euGenes: HUgn113451
ECgene: ADC Kegg: 113451 H-InvDB: ADC

(According to HUGE)
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HUGE: KIAA1945

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ADC Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ADC gene:
Search GeneIP for patents involving ADC

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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