ADC Gene

Aliases
for ADC gene

Previous GC identifers: GC01P033216 GC01P033319 GC01P031663

Summaries
for ADC gene

Genomic Views
for ADC gene

RefSeq DNA sequence:

NC_000001.10  NC_018912.1  NT_032977.9  

SwitchGear Promoter luciferase reporter plasmid: ADC promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADC

ADC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P033546:  view genomic region     (about GC identifiers)

Proteins
for ADC gene

Explore the universe of human proteins at neXtProt for ADC: NX_Q96A70

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for ADC
	GenScript Custom Purified and Recombinant Proteins Services for ADC
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ADC

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for ADC
	GenScript Custom Superior Antibodies Services for ADC
	Novus Biologicals ADC Antibodies
	Abcam antibodies for ADC
	Uscn Antibodies for ADC
	Search ThermoFisher Antibodies for ADC

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ADC
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ADC

Protein Domains /
Families
for ADC gene

ProtoNet protein and cluster: Q96A70

Function
for ADC gene

Enzyme Number (IUBMB): EC 4.1.1.19¹

miRNA Products:		OriGene 3'-UTR Clone: ADC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADC
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate ADC:
		hsa-miR-153 hsa-miR-448
		SwitchGear 3'UTR luciferase reporter plasmid: ADC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADC (see all 6) OriGene siRNA: ADC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADC

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ADC

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADC OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript Custom all cDNA clones Services for ADC
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADC

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ADC
		Search LifeMap BioReagents cell lines for ADC

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADC

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

Pathways & Interactions
for ADC gene

	Super-pathway	contained gene-specific pathways
1	Metabolism	Metabolism 1.00 Metabolic pathways 0.38
2	Agmatine biosynthesis	Agmatine biosynthesis 1.00 putrescine biosynthesis III 0.33
3	Metabolism of amino acids and derivatives	Metabolism of amino acids and derivatives 1.00
4	Arginine and proline metabolism	Arginine and proline metabolism 1.00
5	Methionine salvage pathway	Metabolism of polyamines 0.40

1 BioSystems Pathway for ADC

putrescine biosynthesis III

4        Reactome Pathways for ADC

	Agmatine biosynthesis
	Metabolism of polyamines
	Metabolism
	Metabolism of amino acids and derivatives

2         Kegg Pathways  (Kegg details for ADC)

	Arginine and proline metabolism
	Metabolic pathways

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

Drugs & Compounds
for ADC gene

Transcripts
for ADC gene

Expression
for ADC gene

ADC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAGTGGGCC

Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)			Lateral Plate Mesoderm, Neural Crest
	PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADC

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADC

Orthologs
for ADC gene

Paralogs
for ADC gene

Paralogs for ADC gene

ODC1²  AZIN1²  

2 SIMAP similar genes for ADC using alignment to 3 protein entries:     ADC_HUMAN (see all proteins):

ODC1    AZIN1

ADC for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for ADC
PGOHUM00000263037

Genomic Variants
for ADC gene

10/716 NCBI SNPs in ADC are shown (see all 716)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1169060031,2	F,	--	33544855(+)	TTATAT/CGTCCC	1	--	us2k1		1		EA	120
rs796598141,2	C,F,	--	33544893(+)	NNNNGC/TTTCTG	1	--	us2k1		1		NA	120
rs605277271,2	C,	--	33544923(+)	TGTGTA/GCTGAG	1	--	us2k1		2		WA	120
rs1457285681,2		--	33544974(+)	AAGGCA/GGGACA	1	--	us2k1		0	--	--	--	--
rs358424481,2	C,F,	--	33545024(+)	GGGCAT/CGGTGG	1	--	us2k1		9		NA WA CSA EA	370
rs1849865311,2		--	33545025(+)	GGCATA/GGTGGC	1	--	us2k1		0	--	--	--	--
rs1478520741,2		--	33545035(+)	CTCACA/GCCTGT	1	--	us2k1		0	--	--	--	--
rs1413872331,2		--	33545219(+)	TTGAGC/GCTGGG	1	--	us2k1		0	--	--	--	--
rs1146842581,2		--	33545354(+)	ATATGG/ATAGAC	1	--	us2k1		1		WA	118
rs1469956261,2		--	33545473(+)	CTGCTC/GCAGCA	1	--	us2k1		0	--	--	--	--

HapMap Linkage Disequilibrium report for ADC (33546705 - 33586131 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ADC: --
Human Gene Mutation Database (HGMD): ADC

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADC

DNA2.0 Custom Variant and Variant Library Synthesis for ADC

Disorders / Diseases
for ADC gene

12 diseases for ADC

2 Novoseek disease relationships for ADC gene    About this table

Publications
for ADC gene

PubMed articles for ADC gene, integrated from 9 sources (see all 74): (articles sorted by number of sources associating them with ADC)

Utopia: connect your pdf to the dynamic world of online information

1. Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. (PubMed id 14738999)^{1, 2, 3, 9} Zhu M.Y....Regunathan S. (2004)
2. Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes. (PubMed id 11587527)^{1, 2, 3, 9} Pitkaenen L.T.... Andersson L.C. (2001)
3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
6. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)^{1, 2} Nagase T.... Ohara O. (2001)
7. Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. (PubMed id 16916800)^{1, 9} Lopez-Contreras A.J....Penafiel R. (2006)
8. Putrescine biosynthesis in mammalian tissues. (PubMed id 14763899)^{1, 9} Coleman C.S....Pegg A.E. (2004)
9. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PubMed id 17900240)^{1, 9} Kanerva K....Andersson L.C. (2008)
10. Functional classification of amino acid decarboxylases from the alanine racemase structural family by phylogenetic studies. (PubMed id 16997906)^{7, 9} Kidron H....Salminen T.A. (2007)

External Searches for ADC gene

Genome Databases showing ADC gene

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Specialized Databases showing ADC gene

Products
for ADC gene