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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADC Gene

protein-coding   GIFtS: 61
GCID: GC01P033546

Arginine Decarboxylase

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arginine Decarboxylase1 2     ODC1L2
Ornithine Decarboxylase Like1 2     Antizyme Inhibitor 22
Ornithine Decarboxylase-Like Protein2 3     ODC Antizyme Inhibitor-22
ARGDC2 3     Ornithine Decarboxylase-Paralog2
ODC-p2 3     EC 4.1.1.193
ODC-paralogue2 3     KIAA19453
AZI22     ODCP3

External Ids:    HGNC: 299571   Entrez Gene: 1134512   Ensembl: ENSG000001429207   OMIM: 6083535   UniProtKB: Q96A703   

Export aliases for ADC gene to outside databases

Previous GC identifers: GC01P033216 GC01P033319 GC01P031663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ADC Gene: 
ADC (arginine decarboxylase) is a protein-coding gene. Diseases associated with ADC include hyperargininemia, and spinal cord injury, and among its related super-pathways are Metabolic pathways and Agmatine biosynthesis. GO annotations related to this gene include ornithine decarboxylase activator activity and arginine decarboxylase activity. An important paralog of this gene is ODC1.

UniProtKB/Swiss-Prot: ADC_HUMAN, Q96A70
Function: Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity

Gene Wiki entry for ADC Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_032977.9  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADC gene promoter:
         c-Fos   AP-1   CUTL1   C/EBPalpha   CHOP-10   E2F-1   E2F   c-Jun   ZID   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADC promoter sequence
   Search SABiosciences Chromatin IP Primers for ADC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35.1   Ensembl cytogenetic band:  1p35.1   HGNC cytogenetic band: 1p35.1

ADC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P033546:  view genomic region     (about GC identifiers)

Start:
33,546,705 bp from pter      End:
33,586,131 bp from pter
Size:
39,427 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADC_HUMAN, Q96A70 (See protein sequence)
Recommended Name: Arginine decarboxylase  
Size: 460 amino acids; 49980 Da
Cofactor: Pyridoxal phosphate (By similarity)
Secondary accessions: B2RDU5 D3DPQ9 Q5TIF4 Q5TIF5 Q5TIF6 Q8TF56 Q96L54 Q96L55 Q96L56 Q96L57
Q96MD9
Alternative splicing: 5 isoforms:  Q96A70-1   Q96A70-2   Q96A70-3   Q96A70-4   Q96A70-5   

Explore the universe of human proteins at neXtProt for ADC: NX_Q96A70

Explore proteomics data for ADC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96A70

  • ADC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADC Protein Expression
    REFSEQ proteins: NP_443724.1  
    ENSEMBL proteins: 
     ENSP00000294517   ENSP00000362542   ENSP00000362539   ENSP00000362540   ENSP00000381233  
     ENSP00000351508  
    Reactome Protein details: Q96A70
    Human Recombinant Protein Products for ADC: 
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    Cloud-Clone Corp. Proteins for ADC 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--

    ADC for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: L-Arginine decarboxylase  
    Decarboxylases

    5/7 InterPro protein domains (see all 7):
     IPR009006 Ala_racemase/Decarboxylase_C
     IPR002433 Orn_de-COase
     IPR000183 Orn/DAP/Arg_de-COase
     IPR022644 De-COase2_N
     IPR022643 De-COase2_C

    Graphical View of Domain Structure for InterPro Entry Q96A70

    ProtoNet protein and cluster: Q96A70

    2 Blocks protein domains:
    IPB000183 Orn/DAP/Arg decarboxylase
    IPB002433 Ornithine decarboxylase signature


    UniProtKB/Swiss-Prot: ADC_HUMAN, Q96A70
    Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family


    ADC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADC_HUMAN, Q96A70
    Function: Decarboxylates L-arginine to agmatine. Truncated splice isoforms probably lack activity
    Catalytic activity: L-arginine = agmatine + CO(2)

         Enzyme Number (IUBMB): EC 4.1.1.191

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0005515protein binding ----
    GO:0008792arginine decarboxylase activity IEA--
    GO:0042978ornithine decarboxylase activator activity IEA--
         
    ADC for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    2putrescine biosynthesis III
    Agmatine biosynthesis0.33
    putrescine biosynthesis III0.33
    3Methionine salvage pathway
    Metabolism of polyamines0.40
    4Arginine and proline metabolism
    Arginine and proline metabolism0.35
    5Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ADC
        putrescine biosynthesis III


    4        Reactome Pathways for ADC
        Agmatine biosynthesis
    Metabolism of polyamines
    Metabolism
    Metabolism of amino acids and derivatives


    2         Kegg Pathways  (Kegg details for ADC):
        Arginine and proline metabolism
    Metabolic pathways


    ADC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for ADC (ENSP000002945174) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AGMATENSP000003649864STRING: ENSP00000364986
    ARG1ENSP000003570664STRING: ENSP00000357066
    ARG2ENSP000002617834STRING: ENSP00000261783
    ASLENSP000003071884STRING: ENSP00000307188
    NOS1ENSP000003207584STRING: ENSP00000320758
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006591ornithine metabolic process IEA--
    GO:0006595polyamine metabolic process TAS--
    GO:0006596polyamine biosynthetic process IEA--
    GO:0007283spermatogenesis NAS11587527
    GO:0034641cellular nitrogen compound metabolic process TAS--

    ADC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADC

    8 HMDB Compounds for ADC    About this table
    CompoundSynonyms CAS #PubMed Ids
    Agmatine(4-Aminobutyl)guanidine (see all 11)306-60-5--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    FamotidineAmfamox (see all 83)76824-35-6--
    Gamma-Aminobutyric acid3-Carboxypropylamine (see all 27)56-12-2--
    Guanidine(4-Aminobutyl) guanidine (see all 8)50-01-1--
    L-Arginine(S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoate (see all 14)74-79-3--
    L-Glutamic acid(2S)-2-Aminopentanedioate (see all 49)56-86-0--
    Pyridoxal 5'-phosphateApolon B6 (see all 27)54-47-7--

    2 DrugBank Compounds for ADC    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Pyridoxal PhosphateCodecarboxylase (see all 9)54-47-7targetcofactor11168717 11980912 15583399 16997906 17305368
    L-Arginine(S)-2-Amino-5-guanidinovaleric acid (see all 4)74-79-3target--17287563 17653850 16703907 17025265

    10/20 Novoseek inferred chemical compound relationships for ADC gene (see all 20)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    agmatine 94.6 34 14738999 (3), 9494113 (1), 9851555 (1), 15465778 (1) (see all 21)
    putrescine 84.1 19 14684170 (2), 9494113 (1), 14763899 (1), 11537482 (1) (see all 11)
    ornithine 81.3 12 17900240 (1), 9753623 (1), 10691775 (1), 16997906 (1) (see all 10)
    arginine 81 131 8300600 (5), 17900240 (2), 8181483 (2), 15028566 (2) (see all 52)
    diaminopimelate 73.9 2 8181483 (1)
    spermine 65.7 5 10853267 (1), 11683273 (1), 16511187 (1), 7698471 (1)
    spermidine 60.7 2 10853267 (1), 16511187 (1)
    nitric oxide 49.1 14 7532730 (2), 9806879 (1), 15465778 (1), 17287563 (1) (see all 9)
    amine 46.1 7 9494113 (1), 15028566 (1), 17653850 (1), 14738999 (1) (see all 5)
    proline 34.7 2 15465778 (1), 8954792 (1)

    Search CenterWatch for drugs/clinical trials and news about ADC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADC gene: 
    NM_052998.2  

    Unigene Cluster for ADC:

    Arginine decarboxylase
    Hs.101807  [show with all ESTs]
    Unigene Representative Sequence: AL832640
    18/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000478635 ENST00000294517(uc001bwr.3 uc001bws.3 uc009vue.3)
    ENST00000481886(uc001bwu.3 uc001bwv.3) ENST00000475935(uc001bwt.1)
    ENST00000462920 ENST00000471119 ENST00000495135 ENST00000477570 ENST00000483027
    ENST00000492420 ENST00000373443(uc001bwy.1 uc001bwz.1) ENST00000497710
    ENST00000473089 ENST00000484656(uc001bwx.1) ENST00000373440 ENST00000373441
    ENST00000478204 ENST00000497280
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Additional mRNA sequence: 

    AK057051.1 AK095127.1 AK122697.1 AK315677.1 AL832640.2 AY050634.1 AY050635.1 AY050636.1 
    AY050637.1 AY050638.1 AY325129.1 BC010449.1 BC028128.1 

    20 DOTS entries:

    DT.92417781  DT.100024280  DT.411650  DT.121430699  DT.97788716  DT.100783614  DT.101983638  DT.121430748 
    DT.40294281  DT.100783613  DT.40118336  DT.92040906  DT.95074863  DT.100783615  DT.100810798  DT.95074872 
    DT.95079142  DT.121430766  DT.91760719  DT.91809954 

    24/84 AceView cDNA sequences (see all 84):

    BM806760 AY050636 AA719603 NM_052998 H26992 AK057051 AA954753 BQ066847 
    BC010449 AY050637 AL535454 N74336 AI632488 BC028128 AY050638 AB075825 
    AY050635 AW450278 AY325129 AY050634 AK122697 AI611040 AI097297 CR593091 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for ADC (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
    SP1:                                            -     -                       -                                   -           -                           
    SP2:                    -     -                 -     -                       -                                   -           -                           
    SP3:                    -     -     -     -     -     -                       -                                   -           -                           
    SP4:                    -     -                                               -                                   -           -                           
    SP5:                                            -     -                       -                                               -                           


    ECgene alternative splicing isoforms for ADC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADC expression in normal human tissues (normalized intensities)      ADC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGTGGGCC
    ADC Expression
    About this image


    ADC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/11 selected tissues (see all 11) fully expand
     
     Limb (Muscoskeletal System)    fully expand to see all 2 entries
             limb/hindlimb   
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Mesoderm (Gastrulation Derivatives)
             skeleton/axial skeleton   
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Neural Tube (Nervous System)
             Telencephalon

    See ADC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADC

    SOURCE GeneReport for Unigene cluster: Hs.101807

    UniProtKB/Swiss-Prot: ADC_HUMAN, Q96A70
    Tissue specificity: Highly expressed in brain. Also expressed in testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADC gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adc1 , 5 arginine decarboxylase1, 5 87.51(n)1
    86.27(a)1
      4 (62.48 cM)5
    2426691  NM_172875.21  NP_766463.11 
     1289302335 
    chicken
    (Gallus gallus)
    Aves ADC1 arginine decarboxylase 66.89(n)
    58.64(a)
      428228  XM_425787.3  XP_425787.3 
    lizard
    (Anolis carolinensis)
    Reptilia ADC6
    Uncharacterized protein
    62(a)
    1 ↔ 1
    GL343481.1(612315-621070)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.81282 Transcribed sequence with weak similarity to protein more 73.81(n)    BX736493.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Odc16
    Odc26
    Ornithine decarboxylase 2
    36(a)
    34(a)
    possible ortholog
    possible ortholog
    2R(3892308-3894177)
    2R(3894769-3896567)
    worm
    (Caenorhabditis elegans)
    Secernentea odc-16
    F53F10.26
    Protein F53F10.2, isoform a
    35(a)
    24(a)
    possible ortholog
    1 ↔ many
    V(6898541-6900223)
    I(3831117-3834124)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPE16
    Ornithine decarboxylase, catalyzes the first step ...
    33(a)
    1 → many
    XI(96757-98157)


    ENSEMBL Gene Tree for ADC (if available)
    TreeFam Gene Tree for ADC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADC gene
    ODC12  AZIN12  
    2 SIMAP similar genes for ADC using alignment to 3 protein entries:     ADC_HUMAN (see all proteins):
    ODC1    AZIN1

    ADC for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ADC
    PGOHUM00000263037


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/891 SNPs in ADC are shown (see all 891)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1169060031,2
    C,F--33544855(+) TTATAT/CGTCCC 1 -- us2k11Minor allele frequency- C:0.08EA 120
    rs796598141,2
    C,F--33544893(+) TCCTGC/TTTCTG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs605277271,2
    C,F--33544923(+) TGTGTA/GCTGAG 1 -- us2k12Minor allele frequency- G:0.07WA 120
    rs1457285681,2
    --33544974(+) AAGGCA/GGGACA 1 -- us2k10--------
    rs358424481,2
    C,F--33545024(+) GGGCAT/CGGTGG 1 -- us2k19Minor allele frequency- C:0.32NA WA CSA EA 370
    rs1849865311,2
    --33545025(+) GGCATA/GGTGGC 1 -- us2k10--------
    rs1478520741,2
    C--33545035(+) CTCACA/GCCTGT 1 -- us2k10--------
    rs1413872331,2
    --33545219(+) TTGAGC/GCTGGG 1 -- us2k10--------
    rs107126761,2
    C--33545304(+) AAGAG-/A/AA  
            
    AAAAA
    1 -- us2k1 trp31CSA 2
    rs1146842581,2
    F--33545354(+) ATATGG/ATAGAC 1 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for ADC (33546705 - 33586131 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADC:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv834602CNV Loss17160897


    Human Gene Mutation Database (HGMD): ADC
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ADC
    DNA2.0 Custom Variant and Variant Library Synthesis for ADC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608353    OMIM disorders: --

    10 diseases for ADC:    About MalaCards
    hyperargininemia    spinal cord injury    non-small cell lung carcinoma    hypertension
    pneumonia    alzheimer's disease    lung cancer    hepatitis
    breast cancer    neuronitis


    ADC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for ADC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inflammation 0 1 10431034 (1)
    tumors 0 1 10431034 (1)

    Genetic Association Database (GAD): ADC
    Human Genome Epidemiology (HuGE) Navigator: ADC (21 documents)

    Export disorders for ADC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADC gene, integrated from 9 sources (see all 74):
    (articles sorted by number of sources associating them with ADC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of human arginine decarboxylase, the biosynthetic enzyme for agmatine. (PubMed id 14738999)1, 2, 3, 9 Zhu M.Y....Regunathan S. (2004)
    2. Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes. (PubMed id 11587527)1, 2, 3, 9 Pitkaenen L.T.... Andersson L.C. (2001)
    3. Non-synonymous single-nucleotide polymorphisms associ ated with blood pressure and hypertension. (PubMed id 20147969)1, 4 Hong K.W....Oh B. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PubMed id 11853319)1, 2 Nagase T.... Ohara O. (2001)
    8. Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. (PubMed id 16916800)1, 9 Lopez-Contreras A.J....Penafiel R. (2006)
    9. Putrescine biosynthesis in mammalian tissues. (PubMed id 14763899)1, 9 Coleman C.S....Pegg A.E. (2004)
    10. Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase. (PubMed id 17900240)1, 9 Kanerva K....Andersson L.C. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113451 HGNC: 29957 AceView: ODC-p Ensembl:ENSG00000142920 euGenes: HUgn113451
    ECgene: ADC Kegg: 113451 H-InvDB: ADC

    (According to HUGE)
    About This Section
    HUGE: KIAA1945

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADC gene:
    Search GeneIP for patents involving ADC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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