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Aliases for ADAT3 Gene

Aliases for ADAT3 Gene

  • Adenosine Deaminase, TRNA Specific 3 2 3
  • TRNA-Specific Adenosine-34 Deaminase Subunit ADAT3 3 4
  • Adenosine Deaminase, TRNA-Specific 3 3 5
  • TAD3 3 4
  • Adenosine Deaminase, TRNA-Specific 3, TAD3 Homolog (S. Cerevisiae) 2
  • TRNA-Specific Adenosine Deaminase 3 Homolog (S. Cerevisiae) 2
  • Adenosine Deaminase, TRNA-Specific 3, TAD3 Homolog 3
  • TRNA-Specific Adenosine Deaminase-Like Protein 3 3
  • TRNA-Specific Adenosine Deaminase 3 Homolog 3
  • MSTP121 3
  • FWP005 3
  • MST121 3
  • S863-5 3
  • MRT36 3

External Ids for ADAT3 Gene

Previous GeneCards Identifiers for ADAT3 Gene

  • GC19P001865
  • GC19P001677

Summaries for ADAT3 Gene

GeneCards Summary for ADAT3 Gene

ADAT3 (Adenosine Deaminase, TRNA Specific 3) is a Protein Coding gene. Diseases associated with ADAT3 include mental retardation, autosomal recessive 36 and intellectual disability-strabismus syndrome. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include hydrolase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAT3 Gene

Genomics for ADAT3 Gene

Regulatory Elements for ADAT3 Gene

Enhancers for ADAT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAT3 on UCSC Golden Path with GeneCards custom track

Promoters for ADAT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAT3 Gene

Chromosome:
19
Start:
1,905,372 bp from pter
End:
1,913,447 bp from pter
Size:
8,076 bases
Orientation:
Plus strand

Genomic View for ADAT3 Gene

Genes around ADAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAT3 Gene

Proteins for ADAT3 Gene

  • Protein details for ADAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EY9-ADAT3_HUMAN
    Recommended name:
    Probable inactive tRNA-specific adenosine deaminase-like protein 3
    Protein Accession:
    Q96EY9

    Protein attributes for ADAT3 Gene

    Size:
    351 amino acids
    Molecular mass:
    38071 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for ADAT3 Gene

Proteomics data for ADAT3 Gene at MOPED

Post-translational modifications for ADAT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADAT3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAT3 Gene

Domains & Families for ADAT3 Gene

Suggested Antigen Peptide Sequences for ADAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96EY9

UniProtKB/Swiss-Prot:

ADAT3_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.
genes like me logo Genes that share domains with ADAT3: view

No data available for Gene Families for ADAT3 Gene

Function for ADAT3 Gene

genes like me logo Genes that share phenotypes with ADAT3: view

Human Phenotype Ontology for ADAT3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for ADAT3 Gene

miRTarBase miRNAs that target ADAT3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAT3 Gene

Localization for ADAT3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAT3 Gene COMPARTMENTS Subcellular localization image for ADAT3 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 2
chloroplast 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ADAT3 Gene

Pathways & Interactions for ADAT3 Gene

genes like me logo Genes that share pathways with ADAT3: view

Pathways by source for ADAT3 Gene

Interacting Proteins for ADAT3 Gene

Gene Ontology (GO) - Biological Process for ADAT3 Gene

None

No data available for SIGNOR curated interactions for ADAT3 Gene

Drugs & Compounds for ADAT3 Gene

No Compound Related Data Available

Transcripts for ADAT3 Gene

mRNA/cDNA for ADAT3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ADAT3 Gene

No ASD Table

Relevant External Links for ADAT3 Gene

GeneLoc Exon Structure for
ADAT3
ECgene alternative splicing isoforms for
ADAT3

Expression for ADAT3 Gene

mRNA expression in normal human tissues for ADAT3 Gene

mRNA expression in normal human tissues for ADAT3 Gene

Protein differential expression in normal tissues from HIPED for ADAT3 Gene

This gene is overexpressed in Frontal cortex (50.0) and Fetal gut (15.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAT3 Gene



genes like me logo Genes that share expression patterns with ADAT3: view

Protein tissue co-expression partners for ADAT3 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADAT3 Gene

Orthologs for ADAT3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADAT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAT3 35
  • 82.04 (n)
  • 81.39 (a)
mouse
(Mus musculus)
Mammalia Adat3 35
  • 79.79 (n)
  • 82.18 (a)
Adat3 16
Adat3 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAT3 35
  • 99.73 (n)
  • 99.46 (a)
ADAT3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adat3 35
  • 80.56 (n)
  • 81.61 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAT3 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAT3 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAT3 36
  • 54 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adat3 35
  • 55.34 (n)
  • 55.45 (a)
adat3 36
  • 52 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007066 35
  • 48.06 (n)
  • 36.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10927 35
  • 47.28 (n)
  • 35.71 (a)
CG10927 36
  • 29 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y47D3A.14 36
  • 28 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAD3 36
  • 22 (a)
OneToOne
TAD3 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.909 36
  • 35 (a)
OneToOne
Species with no ortholog for ADAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAT3 Gene

ENSEMBL:
Gene Tree for ADAT3 (if available)
TreeFam:
Gene Tree for ADAT3 (if available)

Paralogs for ADAT3 Gene

No data available for Paralogs for ADAT3 Gene

Variants for ADAT3 Gene

Sequence variations from dbSNP and Humsavar for ADAT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_035804 A breast cancer sample
VAR_069778 Mental retardation, autosomal recessive 36 (MRT36)

Structural Variations from Database of Genomic Variants (DGV) for ADAT3 Gene

Variant ID Type Subtype PubMed ID
esv32942 CNV Gain+Loss 17666407
nsv910499 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294
dgv3612n71 CNV Loss 21882294
nsv910545 CNV Loss 21882294
dgv3613n71 CNV Loss 21882294
dgv3614n71 CNV Loss 21882294
nsv470107 CNV Loss 18288195
dgv3616n71 CNV Loss 21882294
nsv910566 CNV Gain+Loss 21882294
dgv3617n71 CNV Loss 21882294
nsv910569 CNV Loss 21882294
dgv3618n71 CNV Loss 21882294
nsv910579 CNV Gain 21882294
nsv910587 CNV Gain+Loss 21882294
nsv910588 CNV Loss 21882294
nsv518629 CNV Loss 19592680
esv2717853 CNV Deletion 23290073

Variation tolerance for ADAT3 Gene

Gene Damage Index Score: 2.41; 42.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAT3 Gene

HapMap Linkage Disequilibrium report
ADAT3
Human Gene Mutation Database (HGMD)
ADAT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAT3 Gene

Disorders for ADAT3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ADAT3 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
mental retardation, autosomal recessive 36
  • mrt36
intellectual disability-strabismus syndrome
esotropia
  • convergence in manifest squint
- elite association - COSMIC cancer census association via MalaCards
Search ADAT3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ADAT3_HUMAN
  • Mental retardation, autosomal recessive 36 (MRT36) [MIM:615286]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT36 is often associated with esotropia and failure to thrive. Other more variable features included microcephaly, hypotonia, and mild brain abnormalities on MRI, such as dilated ventricles or delayed myelination. {ECO:0000269 PubMed:23620220}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ADAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAT3
genes like me logo Genes that share disorders with ADAT3: view

No data available for Genatlas for ADAT3 Gene

Publications for ADAT3 Gene

  1. Mutation in ADAT3, encoding adenosine deaminase acting on transfer RNA, causes intellectual disability and strabismus. (PMID: 23620220) Alazami A.M. … Alkuraya F.S. (J. Med. Genet. 2013) 3 4 67
  2. RNA editing by adenosine deaminases generates RNA and protein diversity. (PMID: 12457566) Schaub M. … Keller W. (Biochimie 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. (PMID: 20946988) Kim J. … Orkin S.H. (Cell 2010) 3

Products for ADAT3 Gene

Sources for ADAT3 Gene

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