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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAT3 Gene

protein-coding   GIFtS: 42
GCID: GC19P001906

Adenosine Deaminase, TRNA-Specific 3

(Previous names: adenosine deaminase, tRNA-specific 3, TAD3 homolog (S. cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Adenosine Deaminase, TRNA-Specific 31 2     MSTP1212
TRNA-Specific Adenosine-34 Deaminase Subunit ADAT32 3     S863-52
Adenosine Deaminase, TRNA-Specific 3, TAD3 Homolog (S. Cerevisiae)1     TAD32
TRNA-Specific Adenosine Deaminase 3 Homolog (S. Cerevisiae)1     Adenosine Deaminase, TRNA-Specific 3, TAD3 Homolog2
FWP0052     Probable Inactive TRNA-Specific Adenosine Deaminase-Like Protein 32
MRT362     TRNA-Specific Adenosine Deaminase 3 Homolog2
MST1212     TRNA-Specific Adenosine Deaminase-Like Protein 32

External Ids:    HGNC: 251511   Entrez Gene: 1131792   Ensembl: ENSG000002136387   OMIM: 6153025   UniProtKB: Q96EY93   

Export aliases for ADAT3 gene to outside databases

Previous GC identifers: GC19P001865 GC19P001677


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ADAT3 Gene: 
ADAT3 (adenosine deaminase, tRNA-specific 3) is a protein-coding gene. Diseases associated with ADAT3 include atopic dermatitis, and dermatitis, and among its related super-pathways are purine ribonucleosides degradation to ribose-1-phosphate and adenosine nucleotides degradation II. GO annotations related to this gene include hydrolase activity and zinc ion binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAT3 gene promoter:
         Max1   Pax-5   Tal-1   Olf-1   E47   Max   ZID   c-Myc   ATF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ADAT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ADAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P001906:  view genomic region     (about GC identifiers)

Start:
1,905,377 bp from pter      End:
1,913,446 bp from pter
Size:
8,070 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADAT3_HUMAN, Q96EY9 (See protein sequence)
Recommended Name: Probable inactive tRNA-specific adenosine deaminase-like protein 3  
Size: 351 amino acids; 38071 Da
Cofactor: Zinc (By similarity)
Caution: Val-225 is present instead of the conserved Glu which is an active site in the cytidine and
deoxycytidylate deaminase family of enzymes. It is suggested that this protein may act as a regulatory subunit

Explore the universe of human proteins at neXtProt for ADAT3: NX_Q96EY9

Explore proteomics data for ADAT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96EY9

  • ADAT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAT3 Protein Expression
    REFSEQ proteins: NP_612431.2  
    ENSEMBL proteins: 
     ENSP00000332448   ENSP00000404502   ENSP00000473571  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR016193 Cytidine_deaminase-like
     IPR002125 CMP_dCMP_Zn-bd

    Graphical View of Domain Structure for InterPro Entry Q96EY9

    ProtoNet protein and cluster: Q96EY9

    1 Blocks protein domain: IPB002125 Cytidine/deoxycytidylate deaminase

    UniProtKB/Swiss-Prot: ADAT3_HUMAN, Q96EY9
    Similarity: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily


    ADAT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008270zinc ion binding IEA--
    GO:0016787hydrolase activity IEA--
         
    ADAT3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADAT3:
     Increased gamma-H2AX phosphory  Wnt reporter downregulated 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAT3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1adenine and adenosine salvage III
    purine ribonucleosides degradation to ribose-1-phosphate0.75
    adenine and adenosine salvage III0.75
    2purine nucleotides degradation II (aerobic)
    purine nucleotides degradation II (aerobic)0.67
    adenosine nucleotides degradation II0.67


    4 BioSystems Pathways for ADAT3
        adenine and adenosine salvage III
    adenosine nucleotides degradation II
    purine ribonucleosides degradation to ribose-1-phosphate
    purine nucleotides degradation II (aerobic)


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for ADAT3 (Q96EY93 ENSP000003324484) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KAT2AQ928303, ENSP000002259164I2D: score=1 STRING: ENSP00000225916
    NDUFA9Q167953I2D: score=2 
    TMEM214Q6NUQ43I2D: score=2 
    NT5C1AENSP000002356284STRING: ENSP00000235628
    NT5C1BENSP000003529044STRING: ENSP00000352904
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing IEA--

    ADAT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAT3

    Search CenterWatch for drugs/clinical trials and news about ADAT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAT3 gene: 
    NM_138422.2  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000329478(uc002luh.3) ENST00000454697 ENST00000602400
    miRNA
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    Inhib. RNA
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    24/362 AceView cDNA sequences (see all 362):

    BM044653 BU542053 BG163845 BE781053 BU626013 BQ070832 BM691899 AA232686 
    BX107559 AI017809 BM694499 BU844505 AL597181 CR607576 BX105110 BM893832 
    BM703621 BM708430 BM713797 BQ441878 BI771011 BC011824 BM848312 BX647235 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAT3 Expression
    About this image


    See ADAT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAT3
        SABiosciences Custom PCR Arrays for ADAT3
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADAT3 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adat31 , 5 adenosine deaminase, tRNA-specific 3, TAD2 homolog more5
    adenosine deaminase, tRNA-specific 31
    79.79(n)1
    82.18(a)1
      10 (39.72 cM)5
    1001133981  NM_001100606.11  NP_001094076.11 
     806028805 
    lizard
    (Anolis carolinensis)
    Reptilia ADAT36
    Uncharacterized protein
    53(a)
    1 ↔ 1
    GL343220.1(79800-80914)
    zebrafish
    (Danio rerio)
    Actinopterygii adat31 adenosine deaminase, tRNA-specific 3 55.66(n)
    55.66(a)
      368634  NM_001005300.2  NP_001005300.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG109271 CG10927 48.07(n)
    37.07(a)
      37135  NM_137501.2  NP_611345.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y47D3A.146
    Protein Y47D3A.14
    28(a)
    1 ↔ 1
    III(11235577-11236870)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TAD3(YLR316C)4 Subunit of tRNA-specific adenosine-34 deaminase, forms more   --   12(766358-765266) 851027  NP_013420.2 


    ENSEMBL Gene Tree for ADAT3 (if available)
    TreeFam Gene Tree for ADAT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in ADAT3 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358044
    A breast cancer sample4--see VAR_0358042 R C mis40--------

    HapMap Linkage Disequilibrium report for ADAT3 (1905377 - 1913446 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/18 variations for ADAT3 (see all 18):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2717853CNV Deletion23290073
    nsv470107CNV Loss18288195
    dgv3614n71CNV Loss21882294
    nsv910499CNV Loss21882294
    nsv910588CNV Loss21882294
    dgv3609n71CNV Loss21882294
    dgv3613n71CNV Loss21882294
    dgv3617n71CNV Loss21882294
    dgv3618n71CNV Loss21882294
    dgv3612n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 615302    OMIM disorders: --

    2 diseases for ADAT3:    About MalaCards
    atopic dermatitis    dermatitis

    1 disease from the University of Copenhagen DISEASES database for ADAT3:
    Atopic dermatitis

    ADAT3 for disorders           About GeneDecksing


    Export disorders for ADAT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAT3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADAT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RNA editing by adenosine deaminases generates RNA and protein diversity. (PubMed id 12457566)1, 3 Schaub M. and Keller W. (2002)
    2. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    3. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    4. A Myc network accounts for similarities between embry onic stem and cancer cell transcription programs. (PubMed id 20946988)1 Kim J....Orkin S.H. (2010)
    5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    6. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 113179 HGNC: 25151 AceView: C19orf24 Ensembl:ENSG00000213638 euGenes: HUgn113179
    ECgene: ADAT3 H-InvDB: ADAT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAT3 gene:
    Search GeneIP for patents involving ADAT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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