ADAT3 Gene
protein-coding GIFtS: 38
GCID: GC19P001906
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adenosine deaminase, tRNA-specific 3(Previous names: adenosine deaminase, tRNA-specific 3, TAD3 homolog (S....)
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Aliases
for ADAT3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenosine Deaminase, TRNA-Specific 31 2 | | MSTP1212 | | TAD31 2 | | S863-52 | | TRNA-Specific Adenosine-34 Deaminase Subunit ADAT32 3 | | Adenosine Deaminase, TRNA-Specific 3, TAD3 Homolog2 | | Adenosine Deaminase, TRNA-Specific 3, TAD3 Homolog (S. Cerevisiae)1 | | Probable Inactive TRNA-Specific Adenosine Deaminase-Like Protein 32 | | FWP0052 | | TRNA-Specific Adenosine Deaminase 3 Homolog2 | | MST1212 | | TRNA-Specific Adenosine Deaminase-Like Protein 32 |
Export aliases for ADAT3 gene to outside databasesPrevious GC identifers: GC19P001865 GC19P001677 |
Summaries
for ADAT3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ADAT3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAT3 gene promoter:
Max1 Pax-5 Tal-1 Olf-1 E47 Max ZID c-Myc ATF
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAT3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAT3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3ADAT3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P001906: view genomic region
(about GC identifiers)
Start:
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1,905,377 bp from pter |
End:
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1,913,446 bp from pter |
Size:
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8,070 bases |
Orientation:
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plus strand |
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Proteins
for ADAT3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADAT3_HUMAN, Q96EY9 (See
protein sequence)Recommended Name: Probable inactive tRNA-specific adenosine deaminase-like protein 3 Size: 351 amino acids; 38071 Da
Cofactor: Zinc (By similarity)
Caution: Val-225 is present instead of the conserved Glu which is an active site in the cytidine and deoxycytidylatedeaminase family of enzymes. It is suggested that this protein may act as a regulatory subunitExplore the universe of human proteins at neXtProt for ADAT3: NX_Q96EY9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96EY9
ADAT3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612431.2
ENSEMBL proteins: ENSP00000332448 ENSP00000404502
Human Recombinant Protein Products:
ADAT3 Antibody Products:
Assay Products for ADAT3: |
Protein
Domains /
Families
for ADAT3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAT3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96EY9ProtoNet protein and cluster: Q96EY9 1 Blocks protein family: IPB002125 Cytidine/deoxycytidylate deaminase
UniProtKB/Swiss-Prot: ADAT3_HUMAN, Q96EY9Similarity: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily |
Function
for ADAT3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ADAT3 (NM_138422) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAT3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAT3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- |
ADAT3 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ADAT3:
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Pathways & Interactions
for ADAT3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
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| 1 | adenine and adenosine salvage III | | | 2 | purine nucleotides degradation II (aerobic) | |
4  BioSystems Pathways for ADAT3
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAT3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 8)
5/10 Interacting proteins for ADAT3 (Q96EY93 ENSP000003324484) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0008033 | tRNA processing |
IEA | -- |
ADAT3 for ontologies About GeneDecksing
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Drugs & Compounds
for ADAT3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAT3
Search CenterWatch for drugs/clinical trials and news about ADAT3
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Transcripts
for ADAT3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAT3 gene: NM_138422.2 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329478(uc002luh.3) ENST00000454697
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADAT3 (NM_138422) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAT3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAT3 |
24/362 AceView cDNA sequences (see all 362): BM694499 BQ957785 BU541426 BU543140 BI761802 BU845441 BG163845 BX105110 CR607576 NM_138422 BM691899 AI208430 NM_079834 BE782627 BX107559 BU542053 BM044526 BM714166 AK096105 BU541753 BX647235 BM832617 BE207068 AA232686
GeneLoc Exon Structure
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Expression
for ADAT3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAT3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ADAT3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAT3
SABiosciences Custom PCR Arrays for ADAT3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAT3
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ADAT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAT3 |
Orthologs
for ADAT3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of eukaryotes.
Orthologs for ADAT3 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for ADAT3 (if available)
TreeFam Gene Tree for ADAT3 (if available) |
Paralogs
for ADAT3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
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Genomic Variants
for ADAT3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
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Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ADAT3
2 CNVs: 30062 7191 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAT3 |
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Disorders
/ Diseases
for ADAT3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAT3 for disorders About GeneDecksing
3  diseases for ADAT3: About MalaCardsatopic dermatitis dermatitis malaria
Export disorders for ADAT3 gene to outside databases
|
Publications
for ADAT3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
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PubMed articles for ADAT3 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ADAT3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RNA editing by adenosine deaminases generates RNA and protein diversity. (PubMed id 12457566)1, 3 Schaub M. and Keller W. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A Myc network accounts for similarities between embry onic stem and cancer cell transcription programs. (PubMed id 20946988)1 Kim J....Orkin S.H. (2010)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ADAT3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ADAT3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
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Other Databases showing ADAT3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAT3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAT3 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ADAT3 gene:
Search GeneIP for patents involving ADAT3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAT3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADAT3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAT3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAT3 | | | OriGene Protein Over-expression Lysate for ADAT3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADAT3 | | OriGene 3'-UTR Clone for ADAT3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ADAT3 | | OriGene Custom Protein Services for ADAT3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAT3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAT3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAT3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAT3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAT3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAT3 |
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| | | | Search Tocris compounds for ADAT3 |
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 | | | ADAT3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for ADAT3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAT3 |
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