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Aliases for ADAT2 Gene

Aliases for ADAT2 Gene

  • Adenosine Deaminase, TRNA Specific 2 2 3 5
  • TRNA-Specific Adenosine-34 Deaminase Subunit ADAT2 3 4
  • Deaminase Domain-Containing Protein 1 3 4
  • Deaminase Domain Containing 1 2 3
  • DEADC1 3 4
  • Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog (S. Cerevisiae) 2
  • TRNA-Specific Adenosine Deaminase 2 Homolog (S. Cerevisiae) 2
  • Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog 3
  • TRNA-Specific Adenosine Deaminase 2 Homolog 3
  • TRNA-Specific Adenosine Deaminase 2 3
  • EC 3.5.4.- 4
  • DJ20N2.1 3
  • EC 3.5.4 61
  • DJ20N2 3
  • TAD2 3

External Ids for ADAT2 Gene

Previous HGNC Symbols for ADAT2 Gene

  • DEADC1

Previous GeneCards Identifiers for ADAT2 Gene

  • GC06M143789
  • GC06M141307

Summaries for ADAT2 Gene

GeneCards Summary for ADAT2 Gene

ADAT2 (Adenosine Deaminase, TRNA Specific 2) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. GO annotations related to this gene include hydrolase activity and tRNA-specific adenosine deaminase activity.

UniProtKB/Swiss-Prot for ADAT2 Gene

  • Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAT2 Gene

Genomics for ADAT2 Gene

Regulatory Elements for ADAT2 Gene

Enhancers for ADAT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F143408 0.6 Ensembl ENCODE 30.4 +40.4 40438 3.2 ATF1 MLX ARID4B FEZF1 DMAP1 ZNF48 ZNF766 ZNF143 FOS SP5 ADAT2 LOC100288558 TUBB8P2
GH06F143514 0.8 Ensembl ENCODE 9.9 -64.4 -64446 0.9 PHACTR2 PHACTR2-AS1 ADAT2 LOC105378035
GH06F143516 0.2 Ensembl 9.1 -66.3 -66251 1.2 BCOR NFXL1 ZIC2 ZNF644 ZNF2 CTBP1 ZNF366 HNF4G PRDM10 MTA2 PHACTR2-AS1 ADAT2 LOC105378035 PHACTR2
GH06F143513 0.7 ENCODE 6.8 -62.8 -62789 0.2 ELF3 CTCF ZNF175 ARID4B ZIC2 RAD21 GATA2 PATZ1 SMC3 PRDM10 PHACTR2 PHACTR2-AS1 ADAT2 LOC105378035
GH06F143533 1.1 FANTOM5 Ensembl ENCODE 6.4 -92.5 -92548 18.7 PKNOX1 ARID4B ZNF48 ZNF2 YY1 ZNF121 GLIS2 GATA2 FOS ZNF263 ADAT2 PHACTR2 PLAGL1 PHACTR2-AS1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ADAT2 on UCSC Golden Path with GeneCards custom track

Promoters for ADAT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001229434 -50 2801 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for ADAT2 Gene

Chromosome:
6
Start:
143,422,832 bp from pter
End:
143,450,750 bp from pter
Size:
27,919 bases
Orientation:
Minus strand

Genomic View for ADAT2 Gene

Genes around ADAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAT2 Gene

Proteins for ADAT2 Gene

  • Protein details for ADAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6V5-ADAT2_HUMAN
    Recommended name:
    tRNA-specific adenosine deaminase 2
    Protein Accession:
    Q7Z6V5
    Secondary Accessions:
    • A6NL12
    • B3KWY3
    • Q7Z327
    • Q8IY39

    Protein attributes for ADAT2 Gene

    Size:
    191 amino acids
    Molecular mass:
    21046 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH37955.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ADAT2 Gene

    Alternative splice isoforms for ADAT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAT2 Gene

Selected DME Specific Peptides for ADAT2 Gene

Post-translational modifications for ADAT2 Gene

No Post-translational modifications

Domains & Families for ADAT2 Gene

Gene Families for ADAT2 Gene

Suggested Antigen Peptide Sequences for ADAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6V5

UniProtKB/Swiss-Prot:

ADAT2_HUMAN :
  • Contains 1 CMP/dCMP-type deaminase domain.
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
Domain:
  • Contains 1 CMP/dCMP-type deaminase domain.
Family:
  • Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.
genes like me logo Genes that share domains with ADAT2: view

Function for ADAT2 Gene

Molecular function for ADAT2 Gene

UniProtKB/Swiss-Prot Function:
Probably participates in deamination of adenosine-34 to inosine in many tRNAs.

Enzyme Numbers (IUBMB) for ADAT2 Gene

Gene Ontology (GO) - Molecular Function for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008251 tRNA-specific adenosine deaminase activity IEA --
GO:0008270 zinc ion binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with ADAT2: view
genes like me logo Genes that share phenotypes with ADAT2: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAT2 Gene

Localization for ADAT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAT2 Gene COMPARTMENTS Subcellular localization image for ADAT2 gene
Compartment Confidence
nucleus 5
cytosol 3
golgi apparatus 2
chloroplast 1
extracellular 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0052718 tRNA-specific adenosine-34 deaminase complex IBA --
genes like me logo Genes that share ontologies with ADAT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ADAT2 Gene

Pathways & Interactions for ADAT2 Gene

genes like me logo Genes that share pathways with ADAT2: view

Pathways by source for ADAT2 Gene

Gene Ontology (GO) - Biological Process for ADAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002100 tRNA wobble adenosine to inosine editing IEA --
GO:0006400 tRNA modification TAS --
GO:0008033 tRNA processing IEA --
genes like me logo Genes that share ontologies with ADAT2: view

No data available for SIGNOR curated interactions for ADAT2 Gene

Transcripts for ADAT2 Gene

Unigene Clusters for ADAT2 Gene

Adenosine deaminase, tRNA-specific 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAT2 Gene

No ASD Table

Relevant External Links for ADAT2 Gene

GeneLoc Exon Structure for
ADAT2
ECgene alternative splicing isoforms for
ADAT2

Expression for ADAT2 Gene

mRNA expression in normal human tissues for ADAT2 Gene

Protein differential expression in normal tissues from HIPED for ADAT2 Gene

This gene is overexpressed in Fetal testis (47.9) and CD4 Tcells (18.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ADAT2 Gene



Protein tissue co-expression partners for ADAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAT2 Gene:

ADAT2

SOURCE GeneReport for Unigene cluster for ADAT2 Gene:

Hs.709561
genes like me logo Genes that share expression patterns with ADAT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ADAT2 Gene

Orthologs for ADAT2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADAT2 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia ADAT2 34 35
  • 90.83 (n)
cow
(Bos Taurus)
Mammalia DEADC1 35
  • 90 (a)
OneToOne
ADAT2 34
  • 88.66 (n)
rat
(Rattus norvegicus)
Mammalia Adat2 34
  • 85.51 (n)
oppossum
(Monodelphis domestica)
Mammalia ADAT2 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adat2 34 16 35
  • 83.94 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ADAT2 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAT2 34 35
  • 72.12 (n)
lizard
(Anolis carolinensis)
Reptilia ADAT2 35
  • 47 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adat2 34
  • 73.96 (n)
zebrafish
(Danio rerio)
Actinopterygii adat2 34 35
  • 71.84 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013244 34
  • 53.72 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5292 34 35
  • 52.02 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_JC8.4 34
  • 51.83 (n)
JC8.4 35
  • 41 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TAD2 35 37
  • 25 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons emb2191 34
  • 55.49 (n)
rice
(Oryza sativa)
Liliopsida Os03g0321900 34
  • 54.12 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tad2 34
  • 47.24 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1858 34
Species where no ortholog for ADAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAT2 Gene

ENSEMBL:
Gene Tree for ADAT2 (if available)
TreeFam:
Gene Tree for ADAT2 (if available)

Paralogs for ADAT2 Gene

Pseudogenes.org Pseudogenes for ADAT2 Gene

genes like me logo Genes that share paralogs with ADAT2: view

No data available for Paralogs for ADAT2 Gene

Variants for ADAT2 Gene

Sequence variations from dbSNP and Humsavar for ADAT2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs116692495 Benign 143,451,039(+) GGCCT(A/G)AAGAT upstream-variant-2KB, utr-variant-5-prime
rs10484800 -- 143,432,408(+) TCATC(A/G)TTTCT intron-variant
rs1061220 -- 143,426,133(+) TATTT(C/T)GTACA utr-variant-3-prime
rs1061221 -- 143,426,089(-) GAATC(A/C)CTGCC utr-variant-3-prime
rs1065355 -- 143,428,158(-) CCAGG(A/C)AAGTG utr-variant-3-prime

Variation tolerance for ADAT2 Gene

Residual Variation Intolerance Score: 38.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.29; 25.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ADAT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ADAT2 Gene

Disorders for ADAT2 Gene

Relevant External Links for ADAT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAT2

No disorders were found for ADAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAT2 Gene

Publications for ADAT2 Gene

  1. RNA editing by adenosine deaminases generates RNA and protein diversity. (PMID: 12457566) Schaub M. … Keller W. (Biochimie 2002) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. Functional characterization of ATAD2 as a new cancer/testis factor and a predictor of poor prognosis in breast and lung cancers. (PMID: 20581866) Caron C. … Khochbin S. (Oncogene 2010) 3 64

Products for ADAT2 Gene

Sources for ADAT2 Gene

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