ADAT2 Gene
protein-coding GIFtS: 44
GCID: GC06M143789
|
|
adenosine deaminase, tRNA-specific 2(Previous names: deaminase domain containing 1, adenosine deaminase, tRNA-specific...)
(Previous symbol: DEADC1)
| |
Aliases
for ADAT2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Adenosine Deaminase, TRNA-Specific 21 2 | | Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog (S. Cerevisiae)1 | | DEADC11 2 3 | | Adenosine Deaminase, TRNA-Specific 2, TAD2 Homolog2 | | TAD21 2 | | DJ20N21 | | DJ20N2.11 | | TRNA-Specific Adenosine Deaminase 22 | | Deaminase Domain Containing 11 2 | | TRNA-Specific Adenosine Deaminase 2 Homolog2 | | Deaminase Domain-Containing Protein 12 3 | | EC 3.5.4.-3 | | TRNA-Specific Adenosine-34 Deaminase Subunit ADAT22 3 | | EC 3.5.48 |
Export aliases for ADAT2 gene to outside databasesPrevious GC identifer: GC06M141307 |
Summaries
for ADAT2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ADAT2_HUMAN, Q7Z6V5Function: Probably participates in deamination of adenosine-34 to inosine in many tRNAs (By similarity)
|
Genomic Views
for ADAT2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ADAT2 gene promoter:
MEF-2 POU3F2 LCR-F1 YY1 GATA-1 MEF-2A CREB HFH-1 deltaCREB aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ADAT2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAT2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q24.2 Ensembl cytogenetic band: 6q24.2 HGNC cytogenetic band: 6q24.2ADAT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M143789: view genomic region
(about GC identifiers)
Start:
|
143,743,969 bp from pter |
End:
|
143,771,841 bp from pter |
Size:
|
27,873 bases |
Orientation:
|
minus strand |
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Proteins
for ADAT2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ADAT2_HUMAN, Q7Z6V5 (See
protein sequence)Recommended Name: tRNA-specific adenosine deaminase 2 Size: 191 amino acids; 21046 Da
Cofactor: Zinc (By similarity)
Sequence caution: Sequence=AAH37955.2; Type=Erroneous initiation;
1 PDB 3D structure from  and Proteopedia  for ADAT2:3DH1 (3D)
Secondary accessions: A6NL12 B3KWY3 Q7Z327 Q8IY39Alternative splicing: 2 isoforms: Q7Z6V5-1 Q7Z6V5-2 Explore the universe of human proteins at neXtProt for ADAT2: NX_Q7Z6V5
3 DME Specific Peptides for ADAT2 (Q7Z6V5)
ADAT2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_872309.2
ENSEMBL proteins: ENSP00000237283 ENSP00000356565
Human Recombinant Protein Products:
ADAT2 Antibody Products:
Assay Products for ADAT2: |
Protein
Domains /
Families
for ADAT2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ADAT2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z6V5ProtoNet protein and cluster: Q7Z6V5 1 Blocks protein family: IPB002125 Cytidine/deoxycytidylate deaminase
UniProtKB/Swiss-Prot: ADAT2_HUMAN, Q7Z6V5Similarity: Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily |
Function
for ADAT2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ADAT2_HUMAN, Q7Z6V5Function: Probably participates in deamination of adenosine-34 to inosine in many tRNAs (By similarity)Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.4.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAT2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- | | GO:0016787 | hydrolase activity |
IEA | -- |
ADAT2 for ontologies About GeneDecksing
|
Pathways & Interactions
for ADAT2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAT2
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/19 Interacting proteins for ADAT2 (Q7Z6V53 ENSP000002372834) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008033 | tRNA processing |
IEA | -- |
ADAT2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ADAT2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ADAT2
Search CenterWatch for drugs/clinical trials and news about ADAT2
|
Transcripts
for ADAT2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ADAT2 gene: NM_182503.2 Unigene Cluster for ADAT2: Adenosine deaminase, tRNA-specific 2 Hs.709561 [show with all ESTs]Unigene Representative Sequence: NM_1825032 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000237283(uc003qjj.3 uc003qjk.1) ENST00000367593
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ADAT2 (NM_182503) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ADAT2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAT2 |
Additional cDNA sequence: AK126201.1 BC037955.1 BX538182.1 5 DOTS entries: DT.107492 DT.70104466 DT.92057749 DT.40298300 DT.100681452 24/66 AceView cDNA sequences (see all 66): AI304628 BX476676 AW592640 AI148314 BQ440985 BX108973 BG391422 CR616838 BM553554 BX281806 BE791897 BE790527 AJ713343 AI283835 AW303386 BC037955 AI273734 CD656432 BF034101 AA884338 BE159780 AI870084 AI291593 NM_182503
GeneLoc Exon Structure
|
Expression
for ADAT2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ADAT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTAAAATAAA
About this image
See ADAT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ADAT2
SOURCE GeneReport for Unigene cluster: Hs.709561
SABiosciences Custom PCR Arrays for ADAT2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAT2
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAT2 |
Orthologs
for ADAT2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for ADAT2 gene from 9/33 species (see all 33) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Adat21 , 5 |
adenosine deaminase, tRNA-specific 2, TAD2 homolog more5
adenosine deaminase, tRNA-specific 21 |
83.94(n)1
89.01(a)1 |
|
10 (4.94 cM)5
667571 NM_025748.41 NP_080024.31
135528945 |
chicken
(Gallus gallus) |
Aves |
ADAT21 |
adenosine deaminase, tRNA-specific 2 |
72.12(n)
74.27(a) |
|
421670 XM_419709.3 XP_419709.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
adat21 |
adenosine deaminase, tRNA-specific 2, TAD2 homolog more |
72.08(n)
76.87(a) |
|
100034610 NM_001083097.1 NP_001076566.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG52921 |
CG5292 |
52.02(n)
45.86(a) |
|
42079 NM_142353.2 NP_650610.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
CELE_JC8.41 |
Protein JC8.4 |
52.24(n)
44.51(a) |
|
178281 NM_070145.1 NP_502546.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
TAD2(YJL035C)4
TAD21 |
Subunit of tRNA-specific adenosine-34 deaminase, forms more4
Tad2p1 |
50.11(n)1
41.4(a)1 |
|
10(381001-380249)4
8534171, 4 NP_012499.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
emb21911 |
Cytidine/deoxycytidylate deaminase family protein |
55.49(n)
52.17(a) |
|
841237 NM_103714.3 NP_564523.3 |
rice
(Oryza sativa) |
Liliopsida |
Os03g03219001 |
hypothetical protein |
54.12(n)
50(a) |
|
4332682 NM_001056499.1 NP_001049964.1 |
E. coli
(Escherichia coli) |
Gamma proteobacteria |
tadA6 |
tRNA-specific adenosine deaminase |
30(a) |
1 ↔ 1 |
Chromosome(2695376-2695879) |
ENSEMBL Gene Tree for ADAT2 (if available)
TreeFam Gene Tree for ADAT2 (if available) |
Paralogs
for ADAT2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ADAT2 gene
ADAT2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ADAT2
PGOHUM00000233527
|
Genomic Variants
for ADAT2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ADAT2 (143743969 - 143771841 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ADAT2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAT2 |
|
Disorders
/ Diseases
for ADAT2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ADAT2 for disorders About GeneDecksing
7  diseases for ADAT2: About MalaCardsthyroid cancer lung cancer pneumonia tuberculosis
thyroiditis malaria mycobacterium tuberculosis
Export disorders for ADAT2 gene to outside databases
|
Publications
for ADAT2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ADAT2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ADAT2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- RNA editing by adenosine deaminases generates RNA and protein diversity. (PubMed id 12457566)1, 2, 3 Schaub M. and Keller W. (2002)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Functional characterization of ATAD2 as a new cancer/ testis factor and a predictor of poor prognosis in breast and lung cancers. (PubMed id 20581866)1 Caron C....Khochbin S. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
|
External Searches for ADAT2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADAT2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ADAT2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ADAT2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ADAT2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ADAT2 gene:
Search GeneIP for patents involving ADAT2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ADAT2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ADAT2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAT2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAT2 | | | OriGene Protein Over-expression Lysate for ADAT2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ADAT2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAT2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ADAT2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAT2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAT2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAT2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAT2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAT2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAT2 |
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