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Aliases for ADAT1 Gene

Aliases for ADAT1 Gene

  • Adenosine Deaminase, TRNA Specific 1 2 3
  • Adenosine Deaminase, TRNA-Specific 1 3 5
  • TRNA-Specific Adenosine-37 Deaminase 3 4
  • HADAT1 3 4
  • Adenosine Deaminase Acting On TRNA 3
  • EC 3.5.4.34 4
  • EC 3.5.4 63

External Ids for ADAT1 Gene

Previous GeneCards Identifiers for ADAT1 Gene

  • GC16M066563
  • GC16M076593
  • GC16M075371
  • GC16M075412
  • GC16M074190
  • GC16M061385

Summaries for ADAT1 Gene

Entrez Gene Summary for ADAT1 Gene

  • This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]

GeneCards Summary for ADAT1 Gene

ADAT1 (Adenosine Deaminase, TRNA Specific 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include RNA binding and tRNA-specific adenosine deaminase activity. An important paralog of this gene is ADARB2.

UniProtKB/Swiss-Prot for ADAT1 Gene

  • Specifically deaminates adenosine-37 to inosine in tRNA-Ala.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAT1 Gene

Genomics for ADAT1 Gene

Regulatory Elements for ADAT1 Gene

Enhancers for ADAT1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAT1 on UCSC Golden Path with GeneCards custom track

Promoters for ADAT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAT1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAT1 Gene

Chromosome:
16
Start:
75,596,981 bp from pter
End:
75,623,323 bp from pter
Size:
26,343 bases
Orientation:
Minus strand

Genomic View for ADAT1 Gene

Genes around ADAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAT1 Gene

Proteins for ADAT1 Gene

  • Protein details for ADAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUB4-ADAT1_HUMAN
    Recommended name:
    tRNA-specific adenosine deaminase 1
    Protein Accession:
    Q9BUB4
    Secondary Accessions:
    • Q9NVB7
    • Q9UNG3

    Protein attributes for ADAT1 Gene

    Size:
    502 amino acids
    Molecular mass:
    55392 Da
    Cofactor:
    Name=1D-myo-inositol hexakisphosphate; Xref=ChEBI:CHEBI:58130;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAT1 Gene

Proteomics data for ADAT1 Gene at MOPED

Selected DME Specific Peptides for ADAT1 Gene

Post-translational modifications for ADAT1 Gene

  • Ubiquitination at Lys 365
  • Modification sites at PhosphoSitePlus

Domains & Families for ADAT1 Gene

Protein Domains for ADAT1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ADAT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BUB4

UniProtKB/Swiss-Prot:

ADAT1_HUMAN :
  • Contains 1 A to I editase domain.
  • Belongs to the ADAT1 family.
Domain:
  • Contains 1 A to I editase domain.
Family:
  • Belongs to the ADAT1 family.
genes like me logo Genes that share domains with ADAT1: view

No data available for Gene Families for ADAT1 Gene

Function for ADAT1 Gene

Molecular function for ADAT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Adenine(37) in tRNA(Ala) + H(2)O = hypoxanthine(37) in tRNA(Ala) + NH(3).
UniProtKB/Swiss-Prot Function:
Specifically deaminates adenosine-37 to inosine in tRNA-Ala.

Enzyme Numbers (IUBMB) for ADAT1 Gene

Gene Ontology (GO) - Molecular Function for ADAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IMP 10430867
GO:0004000 adenosine deaminase activity IEA --
genes like me logo Genes that share ontologies with ADAT1: view
genes like me logo Genes that share phenotypes with ADAT1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAT1

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAT1 Gene

Localization for ADAT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAT1 Gene COMPARTMENTS Subcellular localization image for ADAT1 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ADAT1 Gene

Pathways & Interactions for ADAT1 Gene

genes like me logo Genes that share pathways with ADAT1: view

Pathways by source for ADAT1 Gene

Interacting Proteins for ADAT1 Gene

Gene Ontology (GO) - Biological Process for ADAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing IEA --
GO:0008033 tRNA processing IMP,TAS 10430867
genes like me logo Genes that share ontologies with ADAT1: view

No data available for SIGNOR curated interactions for ADAT1 Gene

Drugs & Compounds for ADAT1 Gene

(2) Drugs for ADAT1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cladribine Approved, Investigational Pharma Apoptosis inducer in CLL cells 68
Inosine Investigational Pharma 0

(2) Additional Compounds for ADAT1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
Water
  • Dihydrogen oxide
  • Steam
7732-18-5

(1) ApexBio Compounds for ADAT1 Gene

Compound Action Cas Number
Cladribine Apoptosis inducer in CLL cells 4291-63-8
genes like me logo Genes that share compounds with ADAT1: view

Transcripts for ADAT1 Gene

Unigene Clusters for ADAT1 Gene

Adenosine deaminase, tRNA-specific 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAT1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: -
SP3: - - -
SP4:
SP5:

Relevant External Links for ADAT1 Gene

GeneLoc Exon Structure for
ADAT1
ECgene alternative splicing isoforms for
ADAT1

Expression for ADAT1 Gene

mRNA expression in normal human tissues for ADAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ADAT1 Gene

This gene is overexpressed in Blymphocyte (41.7) and CD8 Tcells (27.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ADAT1 Gene



SOURCE GeneReport for Unigene cluster for ADAT1 Gene Hs.729312

mRNA Expression by UniProt/SwissProt for ADAT1 Gene

Q9BUB4-ADAT1_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ADAT1: view

Protein tissue co-expression partners for ADAT1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ADAT1 Gene

Orthologs for ADAT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ADAT1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAT1 35
  • 85.83 (n)
  • 82.48 (a)
ADAT1 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAT1 35
  • 85.65 (n)
  • 83.9 (a)
ADAT1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adat1 35
  • 81.89 (n)
  • 78.47 (a)
Adat1 16
Adat1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAT1 35
  • 98.94 (n)
  • 99 (a)
ADAT1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adat1 35
  • 81.65 (n)
  • 78.83 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAT1 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADAT1 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ADAT1 35
  • 63.99 (n)
  • 58.23 (a)
ADAT1 36
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAT1 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adat1 35
  • 60.36 (n)
  • 56.96 (a)
Str.18961 35
zebrafish
(Danio rerio)
Actinopterygii adat1 35
  • 55.77 (n)
  • 50.54 (a)
adat1 36
  • 48 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009185 35
  • 45.41 (n)
  • 39.91 (a)
fruit fly
(Drosophila melanogaster)
Insecta adat 35
  • 50.2 (n)
  • 39.8 (a)
adat 36
  • 39 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea adr-2 36
  • 18 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G01760 35
  • 44.15 (n)
  • 34.82 (a)
rice
(Oryza sativa)
Liliopsida Os04g0683500 35
  • 52.01 (n)
  • 45.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
OneToOne
Species with no ortholog for ADAT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAT1 Gene

ENSEMBL:
Gene Tree for ADAT1 (if available)
TreeFam:
Gene Tree for ADAT1 (if available)

Paralogs for ADAT1 Gene

Paralogs for ADAT1 Gene

(1) SIMAP similar genes for ADAT1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ADAT1: view

Variants for ADAT1 Gene

Sequence variations from dbSNP and Humsavar for ADAT1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs3743598 - 75,612,787(-) GGGCC(A/C)ACAAC nc-transcript-variant, reference, missense
rs3743599 - 75,612,678(-) TGGGA(A/C/T)TGCAG nc-transcript-variant, reference, missense
rs3743600 - 75,612,562(-) TGGCT(A/C/G)CTGTC nc-transcript-variant, reference, missense
rs56029288 - 75,612,610(+) TGAGA(C/T)TGGGC nc-transcript-variant, reference, missense
rs3863448 -- 75,606,464(-) CAAGA(A/G)AGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAT1 Gene

Variant ID Type Subtype PubMed ID
esv272518 CNV Insertion 20981092

Variation tolerance for ADAT1 Gene

Residual Variation Intolerance Score: 64.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.70; 73.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAT1 Gene

HapMap Linkage Disequilibrium report
ADAT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAT1 Gene

Disorders for ADAT1 Gene

Relevant External Links for ADAT1

Genetic Association Database (GAD)
ADAT1
Human Genome Epidemiology (HuGE) Navigator
ADAT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAT1

No disorders were found for ADAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAT1 Gene

Publications for ADAT1 Gene

  1. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. (PMID: 10430867) Maas S. … Rich A. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23 67
  2. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A. … Hentze M.W. (Cell 2012) 3
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for ADAT1 Gene

Sources for ADAT1 Gene

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