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ADAT1 Gene

protein-coding   GIFtS: 54
GCID: GC16M075632

Adenosine Deaminase, TRNA-Specific 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenosine Deaminase, TRNA-Specific 11 2     TRNA-Specific Adenosine Deaminase 12
TRNA-Specific Adenosine-37 Deaminase2 3     EC 3.5.4.343
HADAT12     hADAT13
Adenosine Deaminase Acting On TRNA2     EC 3.5.48

External Ids:    HGNC: 2281   Entrez Gene: 235362   Ensembl: ENSG000000654577   OMIM: 6042305   UniProtKB: Q9BUB43   

Export aliases for ADAT1 gene to outside databases

Previous GC identifers: GC16M066563 GC16M076593 GC16M075371 GC16M075412 GC16M074190 GC16M061385


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAT1 Gene:
This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine
modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The
protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of
adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described.
(provided by RefSeq, Jul 2010)

GeneCards Summary for ADAT1 Gene:
ADAT1 (adenosine deaminase, tRNA-specific 1) is a protein-coding gene. GO annotations related to this gene include RNA binding and tRNA-specific adenosine deaminase activity. An important paralog of this gene is ADAR.

UniProtKB/Swiss-Prot: ADAT1_HUMAN, Q9BUB4
Function: Specifically deaminates adenosine-37 to inosine in tRNA-Ala




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ADAT1 gene promoter:
         HOXA9   HOXA9B   Pax-5   Lmo2   Tal-1beta   E47   Meis-1b   Hand1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAT1 promoter sequence
   Search Chromatin IP Primers for ADAT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q23.1   Ensembl cytogenetic band:  16q23.1   HGNC cytogenetic band: 16q23

ADAT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAT1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M075632:  view genomic region     (about GC identifiers)

Start:
75,630,879 bp from pter      End:
75,657,221 bp from pter
Size:
26,343 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADAT1_HUMAN, Q9BUB4 (See protein sequence)
Recommended Name: tRNA-specific adenosine deaminase 1  
Size: 502 amino acids; 55392 Da
Cofactor: Binds 1 inositol hexakisphosphate (IP6) per subunit (By similarity)
Secondary accessions: Q9NVB7 Q9UNG3
Alternative splicing: 2 isoforms:  Q9BUB4-1   Q9BUB4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAT1: NX_Q9BUB4

Explore proteomics data for ADAT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys365
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ADAT1 (Q9BUB4) (see all 7)
     LNDSHAE  VYRTGAK  PIYLSAVV  KPGRGDRT 


    See ADAT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036223.2  
    ENSEMBL proteins: 
     ENSP00000455000   ENSP00000455121   ENSP00000456768   ENSP00000310015   ENSP00000457999  
     ENSP00000455108   ENSP00000457501   ENSP00000456751  

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    Novus Biologicals ADAT1 Protein
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    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ADAT1
    Cloud-Clone Corp. Proteins for ADAT1

     
    Search eBioscience for Proteins for ADAT1 

     
    antibodies-online proteins for ADAT1 (14 products) 

     
    antibodies-online peptides for ADAT1

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    antibodies-online antibodies for ADAT1 (18 products) 

    ADAT1 Assay Products:

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    antibodies-online kits for ADAT1 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002466 A_deamin

    Graphical View of Domain Structure for InterPro Entry Q9BUB4

    ProtoNet protein and cluster: Q9BUB4

    1 Blocks protein domain: IPB002466 Adenosine deaminase/editase

    UniProtKB/Swiss-Prot: ADAT1_HUMAN, Q9BUB4
    Similarity: Belongs to the ADAT1 family
    Similarity: Contains 1 A to I editase domain


    Find genes that share domains with ADAT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAT1_HUMAN, Q9BUB4
    Function: Specifically deaminates adenosine-37 to inosine in tRNA-Ala
    Catalytic activity: Adenine(37) in tRNA(Ala) + H(2)O = hypoxanthine(37) in tRNA(Ala) + NH(3)

         Enzyme Numbers (IUBMB): EC 3.5.4.341 EC 3.5.42

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IMP10430867
    GO:0004000adenosine deaminase activity ----
    GO:0008251tRNA-specific adenosine deaminase activity IMP10430867
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ADAT1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAT1:
     Synthetic lethal with c-Myc af 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ADAT1

    miRNA
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    miRTarBase miRNAs that target ADAT1:
    hsa-mir-92b-3p (MIRT040601)

    Block miRNA regulation of human, mouse, rat ADAT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAT1 (see all 10):
    hsa-miR-374b* hsa-miR-3678-3p hsa-miR-4251 hsa-miR-1297 hsa-miR-1303 hsa-miR-29a* hsa-miR-26a hsa-miR-921
    SwitchGear 3'UTR luciferase reporter plasmidADAT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAT1

    Gene Editing
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    OriGene ORF clones in mouse, rat for ADAT1
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    GenScript: all cDNA clones in your preferred vector: ADAT1 (NM_012091)
    Sino Biological Human cDNA Clone for ADAT1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAT1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAT1
    Interactions:

        Search GeneGlobe Interaction Network for ADAT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ADAT1 (ENSP000003100154) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    PSMA6ENSP000002614794STRING: ENSP00000261479
    PSMA2ENSP000002233214STRING: ENSP00000223321
    PSMA7ENSP000003599104STRING: ENSP00000359910
    PSMA8ENSP000003111214STRING: ENSP00000311121
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing ----
    GO:0008033tRNA processing IMP10430867

    Find genes that share ontologies with ADAT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAT1

    1 HMDB Compound for ADAT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Inosine(-)-Inosine (see all 41)58-63-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAT1 gene: 
    NM_012091.3  

    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000568510 ENST00000566450 ENST00000566445(uc002fep.2 uc002feo.2)
    ENST00000568478 ENST00000307921 ENST00000568001 ENST00000567281 ENST00000565109
    ENST00000564657 ENST00000562374
    miRNA
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    Block miRNA regulation of human, mouse, rat ADAT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAT1 (see all 10):
    hsa-miR-374b* hsa-miR-3678-3p hsa-miR-4251 hsa-miR-1297 hsa-miR-1303 hsa-miR-29a* hsa-miR-26a hsa-miR-921
    SwitchGear 3'UTR luciferase reporter plasmidADAT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAT1
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    GenScript: all cDNA clones in your preferred vector: ADAT1 (NM_012091)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAT1
    Primer
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    OriGene qPCR primer pairs and template standards for ADAT1
    OriGene qSTAR qPCR primer pairs in human, mouse for ADAT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAT1
      QuantiTect SYBR Green Assays in human, mouse, rat ADAT1
      QuantiFast Probe-based Assays in human, mouse, rat ADAT1

    Selected AceView cDNA sequences (see all 203):

    CB132377 BX280059 R34251 BG823323 AA398169 BF197521 BM931301 AI222794 
    CR620108 BF513691 BP358039 AI248552 BU623255 AL598909 CA416245 AW004791 
    BI334712 CA411600 BG034525 AK025820 AK001687 AA973443 BC002758 BM462730 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADAT1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -                             -                                                     -               
    SP2:              -                                                                                                   
    SP3:              -                             -     -                                                               
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ADAT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCTGTAGTG
    ADAT1 Expression
    About this image


    ADAT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)
             Telencephalon
    ADAT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAT1 Protein Expression

    UniProtKB/Swiss-Prot: ADAT1_HUMAN, Q9BUB4
    Tissue specificity: Ubiquitously expressed

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ADAT1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adat11 , 5 adenosine deaminase, tRNA-specific 11, 5 81.89(n)1
    78.47(a)1
      8 (58.23 cM)5
    309471  NM_013925.41  NP_038953.11 
     1119669085 
    chicken
    (Gallus gallus)
    Aves ADAT11 adenosine deaminase, tRNA-specific 1 63.99(n)
    58.23(a)
      415886  NM_001012779.1  NP_001012797.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAT16
    adenosine deaminase, tRNA-specific 1
    48(a)
    1 ↔ 1
    GL343483.1(262354-266866)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.189612 Transcribed sequence with weak similarity to protein more 76.54(n)    BX772148.1 
    zebrafish
    (Danio rerio)
    Actinopterygii adat11 adenosine deaminase, tRNA-specific 1 55.77(n)
    50.54(a)
      792614  NM_001082887.1  NP_001076356.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta adat1 adat 50.2(n)
    39.8(a)
      34787  NM_001273521.1  NP_001260450.1 
    worm
    (Caenorhabditis elegans)
    Secernentea adr-26
    Protein ADR-2 (adr-2) mRNA, complete cds
    18(a)
    1 ↔ 1
    III(7230964-7232882) WBGene00000080
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G017601 AT1G01760 44.15(n)
    34.82(a)
      839252  NM_100059.3  NP_171681.3 
    rice
    (Oryza sativa)
    Liliopsida Os04g06835001 Os04g0683500 52.01(n)
    45.05(a)
      4337445  NM_001060837.1  NP_001054302.1 


    ENSEMBL Gene Tree for ADAT1 (if available)
    TreeFam Gene Tree for ADAT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAT1 gene
    ADAR2  ADARB22  ADARB12  ADAD22  ADAD12  
    1 SIMAP similar gene for ADAT1 using alignment to 7 protein entries:     ADAT1_HUMAN (see all proteins):
    NASP

    Find genes that share paralogs with ADAT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAT1 (see all 772)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402355341,2
    --75632120(+) TAGGCA/GTGCGC 2 -- ds50010--------
    rs1162353171,2
    C,F--75632162(+) TAGAAA/CGGGGC 2 -- ds50011Minor allele frequency- C:0.06WA 118
    rs1817277761,2
    C--75632175(+) CACCAC/TGTTGG 2 -- ds50010--------
    rs1864393271,2
    --75632263(+) CACTGC/TACCCG 2 -- ut31 nc-transcript-variant0--------
    rs1148852031,2
    C,F--75632267(+) GCACCC/TGGCCA 2 -- ut31 nc-transcript-variant1Minor allele frequency- T:0.04WA 118
    rs1455560011,2
    --75632451(+) TCACTC/GTGTCA 2 -- ut31 nc-transcript-variant0--------
    rs587195661,2
    C--75632561(+) ACAGGC/TGTGCA 2 -- ut31 nc-transcript-variant0--------
    rs1408212371,2
    C--75632565(+) GCGTGC/TACCAC 2 -- ut31 nc-transcript-variant0--------
    rs1896726281,2
    --75632605(+) AGAGAC/TGGGGT 2 -- ut31 nc-transcript-variant0--------
    rs1826969451,2
    --75632636(+) GGTCTC/TGAACT 2 -- ut31 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for ADAT1 (75630879 - 75657221 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ADAT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv272518CNV Insertion20981092

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAT1
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604230    OMIM disorders: --


    Find genes that share disorders with ADAT1           About GenesLikeMe

    Genetic Association Database (GAD): ADAT1
    Human Genome Epidemiology (HuGE) Navigator: ADAT1 (1 document)

    Export disorders for ADAT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAT1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with ADAT1)
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    1. Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. (PubMed id 10430867)1, 2, 3, 9 Maas S.... Rich A. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PubMed id 19844255)1, 4 Dastani Z....Genest J. (Eur. J. Hum. Genet. 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23536 HGNC: 228 AceView: ADAT1andCHST5 Ensembl:ENSG00000065457 euGenes: HUgn23536
    ECgene: ADAT1 H-InvDB: ADAT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAT1 gene:
    Search GeneIP for patents involving ADAT1

    GeneCards and IP:
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