Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADARB2 Gene

Aliases for ADARB2 Gene

  • Adenosine Deaminase, RNA-Specific, B2 (Non-Functional) 2 3
  • RED2 3 4 6
  • Adenosine Deaminase, RNA-Specific, B2 (RED2 Homolog Rat) 2 3
  • RNA-Dependent Adenosine Deaminase 3 3 4
  • DsRNA Adenosine Deaminase B2 3 4
  • RNA-Editing Deaminase 2 3 4
  • RNA-Editing Enzyme 2 3 4
  • ADAR3 3 4
  • Adenosine Deaminase, RNA-Specific, B2 (RED1 Homolog Rat) 3
  • Double-Stranded RNA-Specific Editase B2 3
  • Adenosine Deaminase, RNA-Specific, B2 2
  • Homolog Of Rat BLUE 3
  • RED2 Homolog (Rat) 2
  • RED2 Homolog 3
  • EC 3.5.1.2 63
  • EC 3.5.-.- 4
  • EC 3.5.4 63

External Ids for ADARB2 Gene

Previous GeneCards Identifiers for ADARB2 Gene

  • GC10U990001
  • GC10M001182
  • GC10M001219

Summaries for ADARB2 Gene

Entrez Gene Summary for ADARB2 Gene

  • This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]

GeneCards Summary for ADARB2 Gene

ADARB2 (Adenosine Deaminase, RNA-Specific, B2 (Non-Functional)) is a Protein Coding gene. Among its related pathways are Purine metabolism (KEGG). GO annotations related to this gene include double-stranded RNA binding and adenosine deaminase activity. An important paralog of this gene is ADAR.

UniProtKB/Swiss-Prot for ADARB2 Gene

  • Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA

Gene Wiki entry for ADARB2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADARB2 Gene

Genomics for ADARB2 Gene

Regulatory Elements for ADARB2 Gene

Genomic Location for ADARB2 Gene

Start:
1,177,313 bp from pter
End:
1,737,476 bp from pter
Size:
560,164 bases
Orientation:
Minus strand

Genomic View for ADARB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADARB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADARB2 Gene

Proteins for ADARB2 Gene

  • Protein details for ADARB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS39-RED2_HUMAN
    Recommended name:
    Double-stranded RNA-specific editase B2
    Protein Accession:
    Q9NS39
    Secondary Accessions:
    • B2RPJ5
    • Q5VUT6
    • Q5VW42

    Protein attributes for ADARB2 Gene

    Size:
    739 amino acids
    Molecular mass:
    80621 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADARB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADARB2 Gene

Proteomics data for ADARB2 Gene at MOPED

Selected DME Specific Peptides for ADARB2 Gene

Post-translational modifications for ADARB2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ADARB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for ADARB2 Gene

Protein Domains for ADARB2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NS39

UniProtKB/Swiss-Prot:

RED2_HUMAN :
  • Q9NS39
Domain:
  • Contains 1 A to I editase domain.
  • Contains 2 DRBM (double-stranded RNA-binding) domains.
genes like me logo Genes that share domains with ADARB2: view

No data available for Gene Families for ADARB2 Gene

Function for ADARB2 Gene

Molecular function for ADARB2 Gene

GENATLAS Biochemistry: double stranded RNA editing deaminase 2
UniProtKB/Swiss-Prot Function: Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA

Enzyme Numbers (IUBMB) for ADARB2 Gene

Gene Ontology (GO) - Molecular Function for ADARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding --
GO:0003725 double-stranded RNA binding TAS 10836796
GO:0003727 single-stranded RNA binding TAS 10836796
GO:0004000 adenosine deaminase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with ADARB2: view

Phenotypes for ADARB2 Gene

GenomeRNAi human phenotypes for ADARB2:
genes like me logo Genes that share phenotypes with ADARB2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ADARB2 Gene

Localization for ADARB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADARB2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADARB2 Gene COMPARTMENTS Subcellular localization image for ADARB2 gene
Compartment Confidence
nucleus 5
mitochondrion 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ADARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ADARB2: view

Pathways for ADARB2 Gene

SuperPathways for ADARB2 Gene

Superpath Contained pathways
1 Purine metabolism (KEGG)
genes like me logo Genes that share pathways with ADARB2: view

Pathways by source for ADARB2 Gene

1 GeneGo (Thomson Reuters) pathway for ADARB2 Gene

Gene Ontology (GO) - Biological Process for ADARB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing --
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with ADARB2: view

Compounds for ADARB2 Gene

(2) Novoseek inferred chemical compound relationships for ADARB2 Gene

Compound -log(P) Hits PubMed IDs
red 2 98.5 8
glutamate 42.3 2
genes like me logo Genes that share compounds with ADARB2: view

Transcripts for ADARB2 Gene

Unigene Clusters for ADARB2 Gene

Adenosine deaminase, RNA-specific, B2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADARB2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
SP1: - - - - - - - - - - - -
SP2:
SP3: - - - - - -
SP4: - -
SP5:
SP6:
SP7:
SP8:

Relevant External Links for ADARB2 Gene

GeneLoc Exon Structure for
ADARB2
ECgene alternative splicing isoforms for
ADARB2

Expression for ADARB2 Gene

mRNA expression in normal human tissues for ADARB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADARB2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (7.8), Brain - Substantia nigra (5.5), and Brain - Hippocampus (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADARB2 Gene

SOURCE GeneReport for Unigene cluster for ADARB2 Gene Hs.586663

mRNA Expression by UniProt/SwissProt for ADARB2 Gene

Q9NS39-RED2_HUMAN
Tissue specificity: Brain specific. Expressed at higher levels in astrocytomas as compared to the normal brain tissue.
genes like me logo Genes that share expressions with ADARB2: view

Orthologs for ADARB2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADARB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ADARB2 35
  • 98.53 (n)
  • 98.47 (a)
ADARB2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ADARB2 35
  • 80.81 (n)
  • 80.08 (a)
ADARB2 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 77 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
ADARB2 35
  • 83.31 (n)
  • 81.7 (a)
mouse
(Mus musculus)
Mammalia Adarb2 35
  • 80.54 (n)
  • 83.13 (a)
Adarb2 16
Adarb2 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ADARB2 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ADARB2 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adarb2 35
  • 80.08 (n)
  • 82.99 (a)
chicken
(Gallus gallus)
Aves ADARB2 35
  • 72.85 (n)
  • 77.42 (a)
ADARB2 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADARB2 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia adarb2 35
  • 67.47 (n)
  • 72.1 (a)
zebrafish
(Danio rerio)
Actinopterygii adarb2 35
  • 68.22 (n)
  • 67.98 (a)
adarb2 36
  • 65 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Adar 36
  • 38 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToMany
Species with no ortholog for ADARB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADARB2 Gene

ENSEMBL:
Gene Tree for ADARB2 (if available)
TreeFam:
Gene Tree for ADARB2 (if available)

Paralogs for ADARB2 Gene

Paralogs for ADARB2 Gene

Selected SIMAP similar genes for ADARB2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ADARB2: view

Variants for ADARB2 Gene

Sequence variations from dbSNP and Humsavar for ADARB2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs866987 -- 1,716,721(+) TTGGA(A/C)ATTTT intron-variant
rs866988 -- 1,716,440(+) GCCAG(G/T)GAAAG intron-variant
rs867263 -- 1,732,557(+) GGGGA(A/G)AAAAA intron-variant
rs867748 -- 1,230,246(-) CCACA(C/T)TCCCA intron-variant
rs867753 -- 1,309,854(-) TAATG(G/T)CCTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADARB2 Gene

Variant ID Type Subtype PubMed ID
esv2660097 CNV Deletion 23128226
dgv589n71 CNV Loss 21882294
nsv894725 CNV Gain 21882294
dgv590n71 CNV Loss 21882294
dgv591n71 CNV Loss 21882294
nsv517780 CNV Loss 19592680
nsv527883 CNV Gain 19592680
nsv894730 CNV Loss 21882294
nsv894731 CNV Loss 21882294
nsv894732 CNV Gain 21882294
nsv509340 CNV Insertion 20534489
esv2659246 CNV Deletion 23128226
esv2729507 CNV Deletion 23290073
esv2729518 CNV Deletion 23290073
esv2729529 CNV Deletion 23290073
esv2729540 CNV Deletion 23290073
esv2729551 CNV Deletion 23290073
esv2729562 CNV Deletion 23290073
esv2729573 CNV Deletion 23290073
nsv25073 CNV Loss 16902084
esv2505047 CNV Deletion 19546169
esv988420 CNV Insertion 20482838
esv1424351 CNV Insertion 17803354
esv2729585 CNV Deletion 23290073
esv2729596 CNV Deletion 23290073
esv2729607 CNV Deletion 23290073
esv2729618 CNV Deletion 23290073
esv1227692 CNV Insertion 17803354
nsv5543 CNV Insertion 18451855
esv28216 CNV Gain+Loss 19812545
esv1541589 CNV Deletion 17803354
esv2729629 CNV Deletion 23290073
esv1388155 CNV Deletion 17803354
esv2729640 CNV Deletion 23290073
esv1596673 CNV Deletion 17803354
esv269952 CNV Insertion 20981092
esv2290022 CNV Deletion 18987734
nsv894733 CNV Loss 21882294
nsv894734 CNV Loss 21882294
esv6414 CNV Gain 19470904
esv2729651 CNV Deletion 23290073
esv2729662 CNV Deletion 23290073
esv28240 CNV Gain 19812545
nsv519127 CNV Loss 19592680
dgv120n67 CNV Gain 20364138
nsv527999 CNV Gain 19592680
esv22298 CNV Loss 19812545
dgv87e201 CNV Deletion 23290073
esv2729684 CNV Deletion 23290073
esv2729707 CNV Deletion 23290073
esv1523107 CNV Deletion 17803354
esv2729718 CNV Deletion 23290073
esv1613053 CNV Deletion 17803354
esv2729729 CNV Deletion 23290073
esv1589394 CNV Deletion 17803354
esv1032656 CNV Insertion 17803354
esv1537660 CNV Insertion 17803354
esv1309284 CNV Insertion 17803354
esv1258640 CNV Insertion 17803354
esv1647895 CNV Insertion 17803354
nsv894735 CNV Loss 21882294
esv2664107 CNV Deletion 23128226
esv21703 CNV Gain 19812545
esv1352224 CNV Deletion 17803354
esv1008495 CNV Insertion 20482838
esv1159013 CNV Insertion 17803354
esv2729740 CNV Deletion 23290073
esv991635 CNV Insertion 20482838
esv1105125 CNV Insertion 17803354
esv2729751 CNV Deletion 23290073
esv8410 CNV Loss 19470904
esv1082929 CNV Deletion 17803354
dgv210e1 CNV Complex 17122850
nsv825212 CNV Gain 20364138
dgv88e201 CNV Deletion 23290073
nsv512137 CNV Loss 21212237
esv2729784 CNV Deletion 23290073
esv2729795 CNV Deletion 23290073
esv2656665 CNV Deletion 23128226
esv3152 CNV Deletion 18987735
esv2664083 CNV Deletion 23128226
esv2729807 CNV Deletion 23290073
esv1009491 CNV Deletion 20482838
esv1543111 CNV Deletion 17803354
esv1921685 CNV Deletion 18987734
esv2729818 CNV Deletion 23290073
nsv25304 CNV Loss 16902084
esv2666228 CNV Deletion 23128226
esv22010 CNV Loss 19812545
esv2729829 CNV Deletion 23290073
esv2729840 CNV Deletion 23290073
esv998745 CNV Deletion 20482838
esv2729851 CNV Deletion 23290073
esv2729862 CNV Deletion 23290073
esv2729873 CNV Deletion 23290073
esv24883 CNV Loss 19812545
esv2649249 CNV Deletion 19546169
esv2247605 CNV Deletion 18987734
esv2729884 CNV Deletion 23290073
esv22628 CNV Gain 19812545
esv2729895 CNV Deletion 23290073
dgv89e201 CNV Deletion 23290073
esv2729918 CNV Deletion 23290073
esv1493086 CNV Deletion 17803354
esv2729929 CNV Deletion 23290073
esv1372493 CNV Deletion 17803354
esv2729940 CNV Deletion 23290073
nsv894736 CNV Gain 21882294
esv1004371 CNV Insertion 20482838
esv1327835 CNV Insertion 17803354
esv2729951 CNV Deletion 23290073
esv2729962 CNV Deletion 23290073
nsv24658 CNV Loss 16902084
esv2729973 CNV Deletion 23290073
esv5029 CNV Deletion 18987735
esv2729984 CNV Deletion 23290073
esv2474802 CNV Deletion 19546169
esv2729995 CNV Deletion 23290073
esv2730006 CNV Deletion 23290073
esv2730017 CNV Deletion 23290073
nsv819780 CNV Loss 19587683
esv2672872 CNV Deletion 23128226
esv2730029 CNV Deletion 23290073
nsv894737 CNV Loss 21882294
esv2730040 CNV Deletion 23290073
esv2730051 CNV Deletion 23290073
esv2730062 CNV Deletion 23290073
esv23632 CNV Loss 19812545
nsv821076 CNV Deletion 20802225
nsv512138 CNV Loss 21212237
nsv24360 CNV Loss 16902084
esv2730073 CNV Deletion 23290073
esv1522620 CNV Deletion 17803354
esv2730084 CNV Deletion 23290073
esv1416852 CNV Deletion 17803354
dgv90e201 CNV Deletion 23290073
esv1588804 CNV Deletion 17803354
esv1761080 CNV Deletion 17803354
esv1608725 CNV Deletion 17803354
esv2730106 CNV Deletion 23290073
esv2730117 CNV Deletion 23290073
esv991990 CNV Deletion 20482838
esv1269144 CNV Deletion 17803354
esv2730128 CNV Deletion 23290073
esv2730140 CNV Deletion 23290073
esv2730151 CNV Deletion 23290073
esv27475 CNV Loss 19812545
esv2730162 CNV Deletion 23290073
esv2730173 CNV Deletion 23290073
esv1437533 CNV Insertion 17803354
esv2730184 CNV Deletion 23290073
esv2128674 CNV Deletion 18987734
esv3846 CNV Deletion 18987735
esv2730195 CNV Deletion 23290073
nsv894738 CNV Loss 21882294
esv2730206 CNV Deletion 23290073
nsv24116 CNV Insertion 16902084
nsv825213 CNV Loss 20364138
nsv5554 CNV Insertion 18451855
esv28361 CNV Gain+Loss 19812545
esv2505756 CNV Deletion 19546169
esv2859 CNV Deletion 18987735
dgv91e201 CNV Deletion 23290073
esv5670 CNV Loss 19470904
esv1567608 CNV Insertion 17803354
dgv92e201 CNV Deletion 23290073
esv1278410 CNV Insertion 17803354
esv2730273 CNV Deletion 23290073
esv1398797 CNV Deletion 17803354
esv1595476 CNV Deletion 17803354
dgv592n71 CNV Gain 21882294
dgv93e201 CNV Deletion 23290073
dgv94e201 CNV Deletion 23290073
esv25433 CNV Gain 19812545
nsv821498 CNV Duplication 20802225
esv2730384 CNV Deletion 23290073
esv2730395 CNV Deletion 23290073
esv2730406 CNV Deletion 23290073
esv2730417 CNV Deletion 23290073
esv23314 CNV Gain 19812545
nsv894741 CNV Loss 21882294
esv1637733 CNV Insertion 17803354
nsv433508 CNV Loss 18776910
esv2730428 CNV Deletion 23290073
esv2730439 CNV Deletion 23290073
esv2730450 CNV Deletion 23290073
esv3423 CNV Deletion 18987735
esv2658549 CNV Deletion 23128226
esv2730461 CNV Deletion 23290073
nsv894742 CNV Loss 21882294
esv2730473 CNV Deletion 23290073
nsv894743 CNV Gain 21882294
esv1231222 CNV Insertion 17803354
esv2730484 CNV Deletion 23290073
esv1670054 CNV Insertion 17803354
esv2730495 CNV Deletion 23290073
esv2730506 CNV Deletion 23290073
esv2730517 CNV Deletion 23290073
esv998686 CNV Deletion 20482838
nsv821012 CNV Deletion 20802225
esv25831 CNV Gain 19812545
nsv25176 CNV Loss 16902084
esv1593452 CNV Deletion 17803354
esv2730528 CNV Deletion 23290073
esv1631254 CNV Deletion 17803354
nsv528115 CNV Gain 19592680

Relevant External Links for ADARB2 Gene

HapMap Linkage Disequilibrium report
ADARB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADARB2 Gene

Disorders for ADARB2 Gene

Relevant External Links for ADARB2

Genetic Association Database (GAD)
ADARB2
Human Genome Epidemiology (HuGE) Navigator
ADARB2
genes like me logo Genes that share disorders with ADARB2: view

No data available for UniProtKB/Swiss-Prot for ADARB2 Gene

Publications for ADARB2 Gene

  1. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. (PMID: 10836796) Chen C.-X. … Nishikura K. (RNA 2000) 2 3 4 23
  2. Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15. (PMID: 9272162) Mittaz L. … Scott H.S. (Hum. Genet. 1997) 2 3 23
  3. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. (PMID: 20011587) Sebastiani P. … Perls T.T. (PLoS ONE 2009) 3 23 48
  4. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PMID: 19197348) Lowe J.K. … Friedman J.M. (PLoS Genet. 2009) 3 48
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for ADARB2 Gene

Sources for ADARB2 Gene

Back to Top

Content