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ADARB2 Gene

protein-coding   GIFtS: 57
GCID: GC10M001219

Adenosine Deaminase, RNA-Specific, B2 (Non-Functional)

(Previous names: adenosine deaminase, RNA-specific, B2 (RED2 homolog rat),...)
  Search for ADARB2
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Adenosine Deaminase, RNA-Specific, B2 (Non-Functional)1 2     RED2 Homolog (Rat)1
RED22 3 5     Adenosine Deaminase, RNA-Specific, B2 (RED1 Homolog Rat)2
Adenosine Deaminase, RNA-Specific, B2 (RED2 Homolog Rat)1 2     Double-Stranded RNA-Specific Editase B22
ADAR32 3     Homolog Of Rat BLUE2
DsRNA Adenosine Deaminase B22 3     RED2 Homolog2
RNA-Dependent Adenosine Deaminase 32 3     EC 3.5.-.-3
RNA-Editing Deaminase 22 3     EC 3.5.1.28
RNA-Editing Enzyme 22 3     EC 3.5.48
Adenosine Deaminase, RNA-Specific, B21     

External Ids:    HGNC: 2271   Entrez Gene: 1052   Ensembl: ENSG000001857367   OMIM: 6020655   UniProtKB: Q9NS393   

Export aliases for ADARB2 gene to outside databases

Previous GC identifers: GC10U990001 GC10M001182


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADARB2 Gene:
This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may
play a regulatory role in RNA editing. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADARB2 Gene:
ADARB2 (adenosine deaminase, RNA-specific, B2 (non-functional)) is a protein-coding gene. GO annotations related to this gene include double-stranded RNA binding and adenosine deaminase activity. An important paralog of this gene is ADAR.

UniProtKB/Swiss-Prot: RED2_HUMAN, Q9NS39
Function: Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases
the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA

Gene Wiki entry for ADARB2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_008705.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADARB2 gene promoter:
         AML1a   Pbx1a   Brachyury   GATA-1   MEF-2A   SRY   c-Myb   aMEF-2   ZIC2/Zic2   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ADARB2 promoter sequence
   Search Chromatin IP Primers for ADARB2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADARB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p15.3   Ensembl cytogenetic band:  10p15.3   HGNC cytogenetic band: 10p15.3

ADARB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADARB2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M001219:  view genomic region     (about GC identifiers)

Start:
1,223,253 bp from pter      End:
1,779,670 bp from pter
Size:
556,418 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: RED2_HUMAN, Q9NS39 (See protein sequence)
Recommended Name: Double-stranded RNA-specific editase B2  
Size: 739 amino acids; 80621 Da
Secondary accessions: B2RPJ5 Q5VUT6

Explore the universe of human proteins at neXtProt for ADARB2: NX_Q9NS39

Explore proteomics data for ADARB2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ADARB2 (Q9NS39)
     GSGGLSS  WNVLGLQGALL 


    See ADARB2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_061172.1  
    ENSEMBL proteins: 
     ENSP00000370713   ENSP00000370711   ENSP00000370706  

    ADARB2 Human Recombinant Protein Products:

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    Novus Biologicals ADARB2 Lysate
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    Cloud-Clone Corp. Proteins for ADARB2

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002466 A_deamin
     IPR014720 dsRNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9NS39

    ProtoNet protein and cluster: Q9NS39

    1 Blocks protein domain: IPB002466 Adenosine deaminase/editase

    UniProtKB/Swiss-Prot: RED2_HUMAN, Q9NS39
    Similarity: Contains 1 A to I editase domain
    Similarity: Contains 2 DRBM (double-stranded RNA-binding) domains


    Find genes that share domains with ADARB2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RED2_HUMAN, Q9NS39
    Function: Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases
    the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA

         Genatlas biochemistry entry for ADARB2:
    double stranded RNA editing deaminase 2

         Enzyme Numbers (IUBMB): EC 3.5.42 EC 3.5.1.22 EC 3.5.-.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding ----
    GO:0003725double-stranded RNA binding TAS10836796
    GO:0003727single-stranded RNA binding TAS10836796
    GO:0004000adenosine deaminase activity IEA--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with ADARB2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADARB2:
     Decreased viability with pacli 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADARB2
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    Selected qRT-PCR Assays for microRNAs that regulate ADARB2 (see all 85):
    hsa-miR-3678-3p hsa-miR-26a-2* hsa-miR-605 hsa-miR-519a hsa-miR-3161 hsa-miR-642b hsa-miR-130b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidADARB2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADARB2

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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADARB2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADARB2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RED2_HUMAN, Q9NS39: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion ----

    Find genes that share ontologies with ADARB2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADARB2 About    
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    ATP ITP metabolism0.31

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ADARB2
        ATP/ITP metabolism


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADARB2
    Interactions:

        Search GeneGlobe Interaction Network for ADARB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for ADARB2 (Q9NS393 ENSP000003707134) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    PSMA2ENSP000002233214STRING: ENSP00000223321
    PSMA6ENSP000002614794STRING: ENSP00000261479
    PSMA7ENSP000003599104STRING: ENSP00000359910
    PSMA8ENSP000003111214STRING: ENSP00000311121
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing ----
    GO:0006397mRNA processing IEA--

    Find genes that share ontologies with ADARB2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADARB2 (RED2)

    2 Novoseek inferred chemical compound relationships for ADARB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    red 2 98.5 13 10854777 (3), 9272162 (3), 10836796 (1), 10581403 (1)
    glutamate 42.3 2 10581403 (1), 10854777 (1)



    Find genes that share compounds with ADARB2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADARB2 gene: 
    NM_018702.3  

    Unigene Cluster for ADARB2:

    Adenosine deaminase, RNA-specific, B2
    Hs.586663  [show with all ESTs]
    Unigene Representative Sequence: NM_018702
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381312(uc001igj.2 uc001igl.4 uc009xhq.3) ENST00000381310(uc001igm.4)
    ENST00000474762 ENST00000490172 ENST00000381305 ENST00000477140 ENST00000469464

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    Selected qRT-PCR Assays for microRNAs that regulate ADARB2 (see all 85):
    hsa-miR-3678-3p hsa-miR-26a-2* hsa-miR-605 hsa-miR-519a hsa-miR-3161 hsa-miR-642b hsa-miR-130b hsa-miR-509-3-5p
    SwitchGear 3'UTR luciferase reporter plasmidADARB2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADARB2
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    GenScript: all cDNA clones in your preferred vector: ADARB2 (NM_018702)
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      QuantiTect SYBR Green Assays in human, mouse, rat ADARB2
      QuantiFast Probe-based Assays in human, mouse, rat ADARB2

    Additional mRNA sequence: 

    AF034837.1 AK055107.1 AK057763.1 AK094294.1 AK123334.1 AK289895.1 AK307451.1 AK308579.1 
    BC047443.1 BC137477.1 BC139725.1 BC140852.1 

    12 DOTS entries:

    DT.99977888  DT.91945848  DT.424357  DT.97793899  DT.121238139  DT.99927532  DT.100694434  DT.121238143 
    DT.121238216  DT.91935334  DT.92418910  DT.97813718 

    Selected AceView cDNA sequences (see all 30):

    BF446376 AA588486 BI669609 AK094294 CN479350 BM926010 W87794 BM724670 
    BG705631 BM808960 BM993818 BE046914 AL707621 BG707096 AK057763 AF034837 
    NM_018702 H20396 AA642681 BF446991 BM707260 AI001883 BP348579 AK055107 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADARB2 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b
    SP1:                                -                 -     -     -     -     -           -     -     -     -     -     -                           
    SP2:                                                                                                                                                
    SP3:                                                                                      -     -     -     -     -     -                           
    SP4:                                                                                                              -     -                           
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for ADARB2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADARB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGTTTGGTT
    ADARB2 Expression
    About this image


    ADARB2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 6 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Limb (Muscoskeletal System)
             Autopod
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
    ADARB2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADARB2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.586663

    UniProtKB/Swiss-Prot: RED2_HUMAN, Q9NS39
    Tissue specificity: Brain specific. Expressed at higher levels in astrocytomas as compared to the normal brain
    tissue

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADARB2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADARB2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adarb21 , 5 adenosine deaminase, RNA-specific, B21, 5 80.54(n)1
    83.13(a)1
      13 (3.48 cM)5
    941911  NM_052977.41  NP_443209.21 
     82028665 
    chicken
    (Gallus gallus)
    Aves ADARB21 adenosine deaminase, RNA-specific, B2 72.85(n)
    77.42(a)
      420461  XM_418563.4  XP_418563.4 
    lizard
    (Anolis carolinensis)
    Reptilia ADARB26
    adenosine deaminase, RNA-specific, B2 (non-functio...
    70(a)
    1 ↔ 1
    6(8204506-8579831)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adarb21 adenosine deaminase, RNA-specific, B2 (non-functional) 67.47(n)
    72.1(a)
      100496062  XM_002935176.2  XP_002935222.2 
    zebrafish
    (Danio rerio)
    Actinopterygii adarb21 adenosine deaminase, RNA-specific, B2 (RED2 homolog more 68.22(n)
    67.98(a)
      558149  XM_681334.5  XP_686426.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta Adar6
    Adenosine deaminase acting on RNA
    38(a)
    1 → many
    X(1667752-1682100)


    ENSEMBL Gene Tree for ADARB2 (if available)
    TreeFam Gene Tree for ADARB2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADARB2 gene
    ADAR2  ADAT12  ADARB12  ADAD22  ADAD12  
    5 SIMAP similar genes for ADARB2 using alignment to 5 protein entries:     RED2_HUMAN (see all proteins):
    hRED1    RED1    ADARB1    ADAR2d    ADAR

    Find genes that share paralogs with ADARB2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADARB2 (see all 15027)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358074
    A colorectal cancer sample4--see VAR_0358072 V I mis40--------
    VAR_0358064
    A colorectal cancer sample4--see VAR_0358062 T M mis40--------
    rs1820582571,2
    --1222768(+) CTGTAA/TGGCTA 1 -- ds50010--------
    rs765437561,2
    C,F--1222785(+) GGCTAG/ATAACT 1 -- ds50011Minor allele frequency- A:0.08NA 120
    rs1504131541,2
    --1222793(+) ACTGCC/TGCTCA 1 -- ds50010--------
    rs774845431,2
    F--1222808(+) GAGGCC/GACTAG 1 -- ds50011Minor allele frequency- G:0.04WA 118
    rs1872134621,2
    --1222906(+) CCTGAA/TCTCAG 1 -- ds50010--------
    rs776643421,2
    C,F--1222923(+) GAAACC/TTCCGC 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs122486311,2
    --1223074(+) gacctC/Tgtgat 1 -- ds50010--------
    rs583294681,2
    C--1223118(+) CCAGGC/TGTGAG 1 -- ds50011Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for ADARB2 (1223253 - 1473253 bp, first 250kb of ADARB2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADARB2 (see all 206):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2729562CNV Deletion23290073
    esv2730273CNV Deletion23290073
    esv2729618CNV Deletion23290073
    esv998686CNV Deletion20482838
    esv2729929CNV Deletion23290073
    esv2729884CNV Deletion23290073
    esv2729684CNV Deletion23290073
    esv2730006CNV Deletion23290073
    esv2730384CNV Deletion23290073
    esv1631254CNV Deletion17803354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602065    OMIM disorders: --


    Find genes that share disorders with ADARB2           About GenesLikeMe

    Genetic Association Database (GAD): ADARB2
    Human Genome Epidemiology (HuGE) Navigator: ADARB2 (3 documents)

    Export disorders for ADARB2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADARB2 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with ADARB2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. (PubMed id 10836796)1, 2, 3, 9 Chen C.-X.... Nishikura K. (RNA 2000)
    2. Localization of a novel human RNA-editing deaminase (hRED2 or ADARB2) to chromosome 10p15. (PubMed id 9272162)1, 3, 9 Mittaz L....Scott H.S. (Hum. Genet. 1997)
    3. RNA editing genes associated with extreme old age in humans and with lifespan in C. elegans. (PubMed id 20011587)1, 4, 9 Sebastiani P....Perls T.T. (PLoS ONE 2009)
    4. Genome-wide association study identifies BICD1 as a susceptibility gene for emphysema. (PubMed id 20709820)1, 4 Kong X....Pillai S.G. (Am. J. Respir. Crit. Care Med. 2011)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines. (PubMed id 20923822)1, 4 Niu N....Wang L. (Genome Res. 2010)
    7. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. (PubMed id 19197348)1, 4 Lowe J.K....Friedman J.M. (PLoS Genet. 2009)
    8. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (Am. J. Hum. Genet. 2006)
    9. The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (Nature 2004)
    10. Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation. (PubMed id 18178553)2, 9 Cenci C.... Gallo A. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 105 HGNC: 227 AceView: ADARB2 Ensembl:ENSG00000185736 euGenes: HUgn105
    ECgene: ADARB2 H-InvDB: ADARB2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADARB2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADARB2 gene:
    Search GeneIP for patents involving ADARB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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