Aliases for ADAR Gene
Aliases for ADAR Gene
External Ids for ADAR Gene
- HGNC: 225
- Entrez Gene: 103
- Ensembl: ENSG00000160710
- OMIM: 146920
- UniProtKB: P55265
Previous HGNC Symbols for ADAR Gene
- IFI4
- G1P1
Previous GeneCards Identifiers for ADAR Gene
- GC01M152370
- GC01M150285
- GC01M151329
- GC01M151772
- GC01M151773
- GC01M151367
- GC01M152821
- GC01M125917
Summaries for ADAR Gene
-
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
GeneCards Summary for ADAR Gene
ADAR (Adenosine Deaminase, RNA Specific) is a Protein Coding gene. Diseases associated with ADAR include Dyschromatosis Symmetrica Hereditaria and Aicardi-Goutieres Syndrome 6. Among its related pathways are Formation of editosomes by ADAR proteins and Interferon gamma signaling. GO annotations related to this gene include poly(A) RNA binding and adenosine deaminase activity. An important paralog of this gene is ADARB1.
UniProtKB/Swiss-Prot for ADAR Gene
-
Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAR Gene
Genomics for ADAR Gene
Regulatory Elements for ADAR Gene
Enhancers for ADAR Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around ADAR on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the ADAR gene promoter:
Regulatory Element Products
Genomic Location for ADAR Gene
- Chromosome:
- 1
- Start:
- 154,582,057 bp from pter
- End:
- 154,628,013 bp from pter
- Size:
- 45,957 bases
- Orientation:
- Minus strand
Genomic View for ADAR Gene
Genes around ADAR on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1q21.3 by Ensembl
- 1q21.3 by Entrez Gene
- 1q21.3 by HGNC
ADAR Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ADAR Gene
Proteins for ADAR Gene
-
Protein details for ADAR Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55265-DSRAD_HUMAN
- Recommended name:
- Double-stranded RNA-specific adenosine deaminase
- Protein Accession:
- P55265
- B1AQQ9
- B1AQR0
- D3DV76
- O15223
- O43859
- O43860
- Q9BYM3
- Q9BYM4
Protein attributes for ADAR Gene
- Size:
- 1226 amino acids
- Molecular mass:
- 136066 Da
- Quaternary structure:
-
- Homodimer. Homodimerization is essential for its catalytic activity. Isoform 5 can form heterodimers with ADARB1/ADAR2. Isoform 1 interacts with ILF2/NF45 and ILF3/NF90. Binding to ILF3/NF90 up-regulates ILF3-mediated gene expression. Isoform 5 (via DRBM 3 domain) interacts with TNPO1. Isoform 5 (via DRBM domains) interacts with XPO5. Isoform 1 and isoform 5 can interact with EIF2AK2/PKR and UPF1.
- SequenceCaution:
-
- Sequence=CAE45853.1; Type=Erroneous termination; Positions=1227; Note=Translated as stop.; Evidence={ECO:0000305};
Three dimensional structures from OCA and Proteopedia for ADAR Gene
Protein Expression for ADAR Gene
Selected DME Specific Peptides for ADAR Gene
- P55265:
-
- QSGPPHEP
- GEGTIPV
- WNVLGLQGALL
- SLGTGNRC
Post-translational modifications for ADAR Gene
- Sumoylation reduces RNA-editing activity.
- Ubiquitination at Lys145, Lys625, and posLast=757757
- Modification sites at PhosphoSitePlus
Other Protein References for ADAR Gene
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for ADAR
- Cell Signaling Technology (CST) Antibodies for ADAR (ADAR)
- Invitrogen Antibodies for ADAR
- antibodies-online Antibodies for ADAR: See all 62
- GeneTex ADAR antibody for ADAR
-
Santa Cruz Biotechnology (SCBT) Antibodies for ADAR
Protein Products
-
OriGene Purified Proteins for ADAR
- Search Origene for MassSpec and Protein Over-expression Lysates for ADAR
- Origene Custom Protein Services for ADAR
- antibodies-online Proteins for ADAR: See all 6
- Search antibodies-online for peptides
- Search GeneTex for Proteins for ADAR
Assay Products
- antibodies-online Kits for ADAR: See all 4
Domains & Families for ADAR Gene
Gene Families for ADAR Gene
Protein Domains for ADAR Gene
Suggested Antigen Peptide Sequences for ADAR Gene
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for ADAR Gene
Function for ADAR Gene
Molecular function for ADAR Gene
- UniProtKB/Swiss-Prot CatalyticActivity:
- Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
- UniProtKB/Swiss-Prot Function:
- Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1). Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1). Impairs HCV replication via RNA editing at multiple sites. Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function. Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5UTR and the Rev and Tat coding sequence. Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles. However, high levels of ADAR1 inhibit HDV replication.
- UniProtKB/Swiss-Prot Induction:
- Isoform 1 is induced by interferon alpha. Isoform 5 is constitutively expressed.
Enzyme Numbers (IUBMB) for ADAR Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,IDA | 22658674 |
| GO:0003726 | double-stranded RNA adenosine deaminase activity | IEA,TAS | -- |
| GO:0004000 | adenosine deaminase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 18362360 |
Phenotypes for ADAR Gene
- MGI mutant phenotypes for ADAR:
- inferred from 8 alleles
- GenomeRNAi human phenotypes for ADAR:
Animal Models for ADAR Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ADAR
-
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAR gene
- Search ViGene Biosciences for ADAR
CRISPR Products
-
OriGene CRISPR knockouts for ADAR
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAR
- GenScript: Design CRISPR guide RNA sequences for ADAR
miRNA for ADAR Gene
- miRTarBase miRNAs that target ADAR
-
- hsa-mir-1-3p (MIRT002820)
- hsa-mir-130b-3p (MIRT020248)
- hsa-mir-93-5p (MIRT028111)
- hsa-mir-1226-3p (MIRT036504)
- hsa-mir-625-5p (MIRT039595)
- hsa-mir-484 (MIRT041936)
- hsa-mir-197-3p (MIRT048109)
- hsa-mir-889-5p (MIRT130764)
- hsa-mir-17-5p (MIRT437884)
- hsa-mir-432-5p (MIRT437885)
- hsa-mir-6780a-5p (MIRT482447)
- hsa-mir-6779-5p (MIRT482448)
- hsa-mir-3689c (MIRT482449)
- hsa-mir-3689b-3p (MIRT482450)
- hsa-mir-3689a-3p (MIRT482451)
- hsa-mir-30b-3p (MIRT482452)
- hsa-mir-6842-3p (MIRT482453)
- hsa-mir-1273h-5p (MIRT482454)
- hsa-mir-6799-5p (MIRT482455)
- hsa-mir-7106-5p (MIRT482456)
- hsa-mir-5787 (MIRT482457)
- hsa-mir-4505 (MIRT482458)
- hsa-mir-3652 (MIRT482459)
- hsa-mir-4430 (MIRT482460)
- hsa-mir-6894-5p (MIRT482461)
- hsa-mir-5580-5p (MIRT482462)
- hsa-mir-4722-5p (MIRT482463)
- hsa-mir-1286 (MIRT482464)
- hsa-mir-873-5p (MIRT482465)
- hsa-mir-3605-5p (MIRT482466)
- hsa-mir-4794 (MIRT482467)
- hsa-mir-664a-5p (MIRT482468)
- hsa-mir-6871-5p (MIRT482469)
- hsa-mir-2392 (MIRT482470)
- hsa-mir-519c-3p (MIRT482471)
- hsa-mir-519b-3p (MIRT482472)
- hsa-mir-519a-3p (MIRT482473)
- hsa-mir-4796-3p (MIRT482474)
- hsa-mir-20b-5p (MIRT482475)
- hsa-mir-106a-5p (MIRT482476)
- hsa-mir-20a-5p (MIRT482477)
- hsa-mir-526b-3p (MIRT482478)
- hsa-mir-519d-3p (MIRT482479)
- hsa-mir-106b-5p (MIRT482480)
- hsa-mir-6883-5p (MIRT549410)
- hsa-mir-6785-5p (MIRT549411)
- hsa-mir-4728-5p (MIRT549412)
- hsa-mir-149-3p (MIRT549413)
- hsa-mir-3609 (MIRT549414)
- hsa-mir-548ah-5p (MIRT549415)
- hsa-mir-27b-3p (MIRT728385)
- hsa-mir-27a-3p (MIRT728386)
miRNA Products
- Search ViGene Biosciences for ADAR
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ADAR
- Browse OriGene Inhibitory RNA Products For ADAR
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAR gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ADAR
- VectorBuilder custom plasmid, inducible vectors for ADAR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for ADAR
-
ViGene Biosciences adenoviral particle packaged cDNA for ADAR gene
-
ViGene Biosciences lentiviral particle packaged cDNA for ADAR gene
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAR gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for ADAR Gene
Localization for ADAR Gene
Subcellular locations from UniProtKB/Swiss-Prot for ADAR Gene
- Isoform 1: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus.
- Isoform 5: Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO1 can mediate its nuclear export.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IDA | 7565688 |
| GO:0005654 | nucleoplasm | TAS,IDA | -- |
| GO:0005730 | nucleolus | IDA | -- |
| GO:0005737 | cytoplasm | TAS,IDA | 7565688 |
| GO:0016020 | membrane | IDA | 19946888 |
Pathways & Interactions for ADAR Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Formation of editosomes by ADAR proteins | ||
| 2 | Influenza A |
.34
|
.34
|
| 3 | RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | ||
| 4 | Peginterferon alpha-2a/Peginterferon alpha-2b Pathway (Hepatocyte), Pharmacodynamics | ||
| 5 | Translational Control | ||
Pathways by source for ADAR Gene
1 Cell Signaling Technology pathway for ADAR Gene
9 Reactome pathways for ADAR Gene
1 PharmGKB pathway for ADAR Gene
3 KEGG pathways for ADAR Gene
1 GeneGo (Thomson Reuters) pathway for ADAR Gene
Interacting Proteins for ADAR Gene
Selected Interacting proteins:
P55265-DSRAD_HUMAN
ENSP00000357459
for ADAR Gene via
IID
STRING
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001649 | osteoblast differentiation | IEA | -- |
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0002244 | hematopoietic progenitor cell differentiation | IEA | -- |
| GO:0002376 | immune system process | IEA | -- |
| GO:0002566 | somatic diversification of immune receptors via somatic mutation | IEA | -- |
No data available for SIGNOR curated interactions for ADAR Gene
Transcripts for ADAR Gene
mRNA/cDNA for ADAR Gene
- (13) REFSEQ mRNAs :
- (18) Additional mRNA sequences :
- (776) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for ADAR Gene
- Adenosine deaminase, RNA-specific:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ADAR
-
Santa Cruz Biotechnology (SCBT) CRISPR for ADAR
- GenScript: Design CRISPR guide RNA sequences for ADAR
miRNA Products
- Search ViGene Biosciences for ADAR
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for ADAR
- Browse OriGene Inhibitory RNA Products For ADAR
-
ViGene Biosciences ready-to-package AAV shRNAs for ADAR gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- Addgene plasmids for ADAR
- VectorBuilder custom plasmid, inducible vectors for ADAR
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for ADAR
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | · | 8d | · | 8e | · | 8f | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | · |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP10: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP11: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP12: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP13: |
| ExUns: | 18c | ^ | 19a | · | 19b | ^ | 20a | · | 20b | · | 20c | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||
| SP5: | |||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||
| SP7: | |||||||||||||||||||||
| SP8: | |||||||||||||||||||||
| SP9: | |||||||||||||||||||||
| SP10: | |||||||||||||||||||||
| SP11: | |||||||||||||||||||||
| SP12: | |||||||||||||||||||||
| SP13: |
Expression for ADAR Gene
This gene is overexpressed in Peripheral blood mononuclear cells (14.6) and Tlymphocyte (7.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADAR Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ADAR Gene:
ADARSOURCE GeneReport for Unigene cluster for ADAR Gene:
Hs.12341mRNA Expression by UniProt/SwissProt for ADAR Gene:
P55265-DSRAD_HUMAN
Tissue specificity:
Ubiquitously expressed, highest levels were found in brain and lung. Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors.
Evidence on tissue expression from TISSUES for ADAR Gene
- Nervous system(5)
- Liver(4.7)
- Kidney(4.6)
- Intestine(3.8)
- Lung(3.7)
- Blood(3.1)
- Skin(3)
- Eye(2.7)
- Heart(2.2)
- Muscle(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAR Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- immune
- integumentary
- lymphatic
- nervous
- skeletal muscle
- skeleton
Organs:
Head and neck:
- brain
- cerebellum
- cerebrospinal fluid
- cranial nerve
- ear
- eye
- eyelid
- face
- head
- meninges
- mouth
- neck
- nose
- outer ear
- pharynx
- skull
Thorax:
- chest wall
- esophagus
Abdomen:
- abdominal wall
- liver
- spleen
- stomach
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- blood
- blood vessel
- bone marrow
- coagulation system
- peripheral nerve
- peripheral nervous system
- red blood cell
- skin
- spinal cord
- white blood cell
Primer Products
-
OriGene qPCR primer pairs and template standards for ADAR
-
OriGene qPCR primer pairs for ADAR
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ADAR Gene
Orthologs for ADAR Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ADAR 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | ADAR 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | ADAR 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Adar 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Adar 34 16 35 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | ADAR 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | ADAR 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ADAR 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | ADAR 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | adar 34 |
|
||
| Str.3278 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | adar-A-prov 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | adar 34 35 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | adr-1 36 |
|
|
- Species where no ortholog for ADAR was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for ADAR Gene
(6) SIMAP similar genes for ADAR Gene using alignment to 6 proteins:
Variants for ADAR Gene
| SNP ID | Clin | Chr 01 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs144119808 | A breast cancer sample | 154,590,263(+) | TTACC(A/T)CTGTG | reference, missense | |
| rs145588689 | Pathogenic, Aicardi-Goutieres syndrome 6 (AGS6) [MIM:615010] | 154,602,065(+) | CAAAG(C/G/T)GGGTG | reference, missense, utr-variant-5-prime | |
| rs28936680 | Pathogenic, Dyschromatosis symmetrica hereditaria (DSH) [MIM:127400] | 154,588,668(-) | GTTTC(C/T)CTACA | reference, missense | |
| rs28936681 | Pathogenic, Dyschromatosis symmetrica hereditaria (DSH) [MIM:127400] | 154,584,993(-) | TCTAT(C/T)TAAGA | reference, missense | |
| rs398122822 | other, Aicardi-Goutieres syndrome 6 (AGS6) [MIM:615010] | 154,588,125(-) | AGAAC(A/G)GTGAG | reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2658585 | CNV | deletion | 23128226 |
| esv32568 | CNV | loss | 17666407 |
| esv33112 | CNV | gain | 17666407 |
| esv33703 | CNV | loss | 17666407 |
| esv3587607 | CNV | loss | 21293372 |
| nsv1161683 | CNV | duplication | 26073780 |
| nsv464050 | CNV | gain | 19166990 |
| nsv470740 | CNV | gain | 18288195 |
| nsv472265 | CNV | novel sequence insertion | 20440878 |
| nsv521887 | CNV | gain | 19592680 |
| nsv547958 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
1.72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.88;
35.06% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for ADAR Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAR Gene
Disorders for ADAR Gene
(20) MalaCards diseases for ADAR Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| dyschromatosis symmetrica hereditaria |
|
|
| aicardi-goutieres syndrome 6 |
|
|
| familial infantile bilateral striatal necrosis |
|
|
| aicardi-goutieres syndrome |
|
|
| adar-related aicardi-goutieres syndrome |
|
|
Search ADAR in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
DSRAD_HUMAN- Aicardi-Goutieres syndrome 6 (AGS6) [MIM:615010]: A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood. {ECO:0000269 PubMed:23001123}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Dyschromatosis symmetrica hereditaria (DSH) [MIM:127400]: An autosomal dominant pigmentary genodermatosis characterized by a mixture of hyperpigmented and hypopigmented macules distributed on the face and the dorsal parts of the hands and feet, that appear in infancy or early childhood. {ECO:0000269 PubMed:12916015, ECO:0000269 PubMed:15146470, ECO:0000269 PubMed:15659327}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Relevant External Links for ADAR
No data available for Genatlas for ADAR Gene
Publications for ADAR Gene
- Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. (PMID: 7972084) Kim U. … Nishikura K. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 22 64
- RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. (PMID: 19124606) Fritz J. … Jantsch M.F. (Mol. Cell. Biol. 2009) 3 4 22 64
- ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication. (PMID: 19605474) Clerzius G. … Gatignol A. (J. Virol. 2009) 3 4 22 64
- Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection. (PMID: 19651874) Doria M. … Michienzi A. (Nucleic Acids Res. 2009) 3 4 22 64
- RNA-specific adenosine deaminase ADAR1 suppresses measles virus- induced apoptosis and activation of protein kinase PKR. (PMID: 19710021) Toth A.M. … Samuel C.E. (J. Biol. Chem. 2009) 3 4 22 64
Products for ADAR Gene
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- antibodies-online Antibodies for ADAR: See all 62
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- ViGene Biosciences adenoviral particle packaged cDNA for ADAR gene
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
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- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for ADAR Gene
- (1) GeneCards
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