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ADAP2 Gene

protein-coding   GIFtS: 51
GCID: GC17P029248

ArfGAP With Dual PH Domains 2

(Previous names: centaurin, alpha 2)
(Previous symbol: CENTA2)
  See ADAP2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ArfGAP With Dual PH Domains 21 2     Centaurin Beta2
CENTA21 2 3 5     Centaurin-Alpha 2 Protein2
Centaurin, Alpha 21 2     centaurin-alpha-22
HSA2721952     cnt-a22
Arf-GAP With Dual PH Domain-Containing Protein 22     Centaurin-alpha-23
cent-b2     Cnt-a23

External Ids:    HGNC: 164871   Entrez Gene: 558032   Ensembl: ENSG000001840607   OMIM: 6086355   UniProtKB: Q9NPF83   

Export aliases for ADAP2 gene to outside databases

Previous GC identifers: GC17P026272 GC17P025459


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ADAP2 Gene:
ADAP2 (ArfGAP with dual PH domains 2) is a protein-coding gene. Diseases associated with ADAP2 include gastrointestinal lymphoma. GO annotations related to this gene include ARF GTPase activator activity and GTPase activator activity. An important paralog of this gene is SMAP1.

UniProtKB/Swiss-Prot: ADAP2_HUMAN, Q9NPF8
Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol
3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two
binding sites for InsP4 with identical affinity

Gene Wiki entry for ADAP2 (CENTA2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAP2 gene promoter:
         TBP   E2F-4   E2F-3a   E2F-5   NF-1   Sp1   E2F-2   PPAR-alpha   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAP2 promoter sequence
   Search Chromatin IP Primers for ADAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

ADAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAP2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P029248:  view genomic region     (about GC identifiers)

Start:
29,233,362 bp from pter      End:
29,286,340 bp from pter
Size:
52,979 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ADAP2_HUMAN, Q9NPF8 (See protein sequence)
Recommended Name: Arf-GAP with dual PH domain-containing protein 2  
Size: 381 amino acids; 44349 Da
Secondary accessions: Q8N4Q6 Q96SD5
Alternative splicing: 2 isoforms:  Q9NPF8-1   Q9NPF8-2   (May be due to a competing acceptor splice site. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ADAP2: NX_Q9NPF8

Explore proteomics data for ADAP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ADAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060874.1  
    ENSEMBL proteins: 
     ENSP00000464120   ENSP00000329468   ENSP00000467079   ENSP00000464121   ENSP00000464155  
     ENSP00000462832   ENSP00000463649   ENSP00000462634  

    ADAP2 Human Recombinant Protein Products:

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    Novus Biologicals ADAP2 Protein
    Novus Biologicals ADAP2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ADAP2 

     
    antibodies-online proteins for ADAP2 (6 products) 

     
    antibodies-online peptides for ADAP2

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    antibodies-online antibodies for ADAP2 (16 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9NPF8

    ProtoNet protein and cluster: Q9NPF8

    2 Blocks protein domains:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ADAP2_HUMAN, Q9NPF8
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 2 PH domains


    Find genes that share domains with ADAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAP2_HUMAN, Q9NPF8
    Function: GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol
    3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two
    binding sites for InsP4 with identical affinity

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005096GTPase activator activity ----
    GO:0005515protein binding IPI--
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding ISS12018390
    GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding IDA14690521
    GO:0008060ARF GTPase activator activity IEA--
         
    Find genes that share ontologies with ADAP2           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ADAP2

    miRNA
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    miRTarBase miRNAs that target ADAP2:
    hsa-mir-744-5p (MIRT037704), hsa-mir-30d-5p (MIRT047793), hsa-mir-26b-5p (MIRT029470)

    Block miRNA regulation of human, mouse, rat ADAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAP2 (see all 12):
    hsa-miR-647 hsa-miR-1231 hsa-miR-4288 hsa-miR-632 hsa-miR-3157-5p hsa-miR-376a* hsa-miR-3920 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidADAP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAP2

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ADAP2_HUMAN, Q9NPF8: Cytoplasm. Cell membrane. Note=Constitutively associated with the plasma membrane. Excluded
    from the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion4
    cytosol3
    nucleus2
    golgi apparatus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA14690521
    GO:0005740mitochondrial envelope ISS12018390
    GO:0005886plasma membrane IDA14690521

    Find genes that share ontologies with ADAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAP2
    Interactions:

        Search GeneGlobe Interaction Network for ADAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for ADAP2 (Q9NPF81, 2, 3 ENSP000003294684) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EEF1GP266412, 3MINT-65569 I2D: score=5 
    IKBKGQ9Y6K91, 3, ENSP000003586224EBI-718895,EBI-81279 I2D: score=1 STRING: ENSP00000358622
    SNCAP378403, ENSP000003383454I2D: score=1 STRING: ENSP00000338345
    PRNPP041563I2D: score=1 
    ARFGAP1ENSP000003146154STRING: ENSP00000314615
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007507heart development IEP16138909
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0043547positive regulation of GTPase activity ----

    Find genes that share ontologies with ADAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAP2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAP2 gene: 
    NM_018404.2  

    Unigene Cluster for ADAP2:

    ArfGAP with dual PH domains 2
    Hs.514063  [show with all ESTs]
    Unigene Representative Sequence: NM_018404
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583688 ENST00000585130 ENST00000330889(uc002hfx.3 uc010csk.3 uc002hfy.3 uc010csl.3)
    ENST00000581548 ENST00000580525 ENST00000581285 ENST00000580526 ENST00000584828
    ENST00000584989 ENST00000480980 ENST00000470962
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAP2 (see all 12):
    hsa-miR-647 hsa-miR-1231 hsa-miR-4288 hsa-miR-632 hsa-miR-3157-5p hsa-miR-376a* hsa-miR-3920 hsa-miR-29a*
    SwitchGear 3'UTR luciferase reporter plasmidADAP2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAP2
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      QuantiFast Probe-based Assays in human, mouse, rat ADAP2

    Additional mRNA sequence: 

    AJ238994.1 AJ242782.1 AJ272195.1 AK074196.1 AK074204.1 AK222526.1 BC033758.1 DQ288859.1 

    13 DOTS entries:

    DT.95362767  DT.99937215  DT.210314  DT.100801664  DT.100781186  DT.120972751  DT.95144288  DT.100691951 
    DT.95297701  DT.100699575  DT.100781188  DT.100781189  DT.40316532 

    Selected AceView cDNA sequences (see all 70):

    NM_018404 BP338580 BQ005022 BQ023170 BQ025678 BM561847 CB133965 BC033758 
    AJ272195 AA768410 CA307252 AW469030 BE504754 N98828 AW083635 AA262556 
    BM922463 AA648844 AK074196 AW003904 AK074204 AI468519 AA031663 BM694487 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ADAP2 (see all 7)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
    SP1:                                                                    -                       -               
    SP2:                                                                    -                       -               
    SP3:                                -                                   -                       -               
    SP4:                    -     -                                                                                 
    SP5:                                                                    -                 -     -               


    ECgene alternative splicing isoforms for ADAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAP2 Expression
    About this image


    ADAP2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Liver (Hepatobiliary System)
    ADAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.514063

    UniProtKB/Swiss-Prot: ADAP2_HUMAN, Q9NPF8
    Tissue specificity: Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly
    expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal
    cord, brain, stomach, trachea, colon, lymph node and bone marrow

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADAP2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adap21 , 5 ArfGAP with dual PH domains 21, 5 86.65(n)1
    85.41(a)1
      11 (47.56 cM)5
    2169911  NM_172133.11  NP_742145.11 
     801541055 
    chicken
    (Gallus gallus)
    Aves ADAP21 ArfGAP with dual PH domains 2 68.89(n)
    64.72(a)
      417409  XM_415661.3  XP_415661.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAP26
    ArfGAP with dual PH domains 2
    56(a)
    1 ↔ 1
    5(23856728-23868358)
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch73-33i10.51 si:ch73-33i10.5 60.74(n)
    58.49(a)
      100331455  XM_002661169.2  XP_002661215.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG82436
    --
    14(a)
    1 → many
    2R(4810290-4812851)
    worm
    (Caenorhabditis elegans)
    Secernentea W09D10.16
    Protein W09D10.1 (W09D10.1) mRNA, complete cds
    15(a)
    1 → many
    III(10736893-10739792) WBGene00012359
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AGE26
    ADP-ribosylation factor (ARF) GTPase activating pr...
    17(a)
    1 → many
    IX(272950-273846) YIL044C


    ENSEMBL Gene Tree for ADAP2 (if available)
    TreeFam Gene Tree for ADAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAP2 gene
    SMAP12  SMAP22  ADAP12  
    8 SIMAP similar genes for ADAP2 using alignment to 7 protein entries:     ADAP2_HUMAN (see all proteins):
    CENTA2    ADAP1    AGAP8    ARFGAP2    GIT1    ARFGAP3
    ARFGAP1    SMAP1

    Find genes that share paralogs with ADAP2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAP2 (see all 722)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1890684951,2
    C--29246803(+) TCTGTC/TGCCCA 1 -- us2k10--------
    rs732656481,2
    C--29246804(+) CTGTCG/ACCCAG 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1491692221,2
    --29246850(+) AACTCC/TGCCTC 1 -- us2k10--------
    rs98937451,2
    C--29247039(+) gattaC/Taggcg 1 -- us2k10--------
    rs1816098951,2
    --29247060(+) CGCCCA/GGCTTT 1 -- us2k10--------
    rs803023281,2
    C,F--29247098(+) GCCTAC/GTTAGA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1866003641,2
    --29247326(+) TCCCAA/TCTTTC 1 -- us2k10--------
    rs1113829051,2
    F--29247582(+) CCAGGG/AATGAC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1468404471,2
    --29247633(+) TGACCA/GTAGGG 1 -- us2k10--------
    rs1819299001,2
    --29247644(+) GCAGGC/GGAAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAP2 (29233362 - 29286340 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ADAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2715813CNV Deletion23290073
    nsv833412CNV Loss17160897
    nsv457720CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608635    OMIM disorders: --

    1 disease for ADAP2:    
    About MalaCards
    gastrointestinal lymphoma

    1 disease from the University of Copenhagen DISEASES database for ADAP2:
    Gastrointestinal lymphoma

    Find genes that share disorders with ADAP2           About GenesLikeMe

    Genetic Association Database (GAD): ADAP2
    Human Genome Epidemiology (HuGE) Navigator: ADAP2 (4 documents)

    Export disorders for ADAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAP2 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ADAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins. (PubMed id 14690521)1, 2, 9 Hanck T.... Reiser G. (J. Neurochem. 2004)
    2. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. RNF135 mutations are not present in patients with Sotos syndrome-like features. (PubMed id 19291764)1, 4 Visser R.... Losekoot M. (Am. J. Med. Genet. A 2009)
    5. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1, 4 Sovio U....Jarvelin M.R. (PLoS Genet. 2009)
    6. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle. (PubMed id 12018390)1, 2 Whitley P.... Holman G.D. (Eur. J. Cell Biol. 2002)
    9. A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions. (PubMed id 10843809)1, 2 Jenne D.E.... Thiel G. (Genomics 2000)
    10. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. (PubMed id 16138909)1, 9 Venturin M....Riva P. (Ann. Hum. Genet. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55803 HGNC: 16487 AceView: CENTA2 Ensembl:ENSG00000184060 euGenes: HUgn55803
    ECgene: ADAP2 H-InvDB: ADAP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ADAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ADAP2 gene:
    Search GeneIP for patents involving ADAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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