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Aliases for ADAP2 Gene

Aliases for ADAP2 Gene

  • ArfGAP With Dual PH Domains 2 2 3 5
  • Centaurin, Alpha 2 2 3
  • Centaurin-Alpha-2 3 4
  • Cnt-A2 3 4
  • CENTA2 3 4
  • Centaurin-Alpha 2 Protein 3
  • Centaurin Beta 3
  • HSA272195 3
  • Cent-B 3

External Ids for ADAP2 Gene

Previous HGNC Symbols for ADAP2 Gene

  • CENTA2

Previous GeneCards Identifiers for ADAP2 Gene

  • GC17P026272
  • GC17P029248
  • GC17P025459

Summaries for ADAP2 Gene

GeneCards Summary for ADAP2 Gene

ADAP2 (ArfGAP With Dual PH Domains 2) is a Protein Coding gene. Diseases associated with ADAP2 include Chromosome 17Q11.2 Deletion Syndrome, 1.4Mb. GO annotations related to this gene include GTPase activator activity and phosphatidylinositol-4,5-bisphosphate binding. An important paralog of this gene is SMAP1.

UniProtKB/Swiss-Prot for ADAP2 Gene

  • GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.

Gene Wiki entry for ADAP2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAP2 Gene

Genomics for ADAP2 Gene

Regulatory Elements for ADAP2 Gene

Enhancers for ADAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAP2 on UCSC Golden Path with GeneCards custom track

Promoters for ADAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAP2 Gene

30,906,344 bp from pter
30,959,398 bp from pter
53,055 bases
Plus strand

Genomic View for ADAP2 Gene

Genes around ADAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAP2 Gene

Proteins for ADAP2 Gene

  • Protein details for ADAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with dual PH domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q8N4Q6
    • Q96SD5

    Protein attributes for ADAP2 Gene

    381 amino acids
    Molecular mass:
    44349 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAP2 Gene


neXtProt entry for ADAP2 Gene

Proteomics data for ADAP2 Gene at MOPED

Post-translational modifications for ADAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cloud-Clone Corp. Antibodies for ADAP2

No data available for DME Specific Peptides for ADAP2 Gene

Domains & Families for ADAP2 Gene

Gene Families for ADAP2 Gene

Protein Domains for ADAP2 Gene

Suggested Antigen Peptide Sequences for ADAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Arf-GAP domain.
  • Contains 1 Arf-GAP domain.
  • Contains 2 PH domains.
genes like me logo Genes that share domains with ADAP2: view

Function for ADAP2 Gene

Molecular function for ADAP2 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for the ADP ribosylation factor family (Potential). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). Possesses a stoichiometry of two binding sites for InsP4 with identical affinity.

Gene Ontology (GO) - Molecular Function for ADAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding ISS 12018390
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 14690521
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding IDA 14690521
genes like me logo Genes that share ontologies with ADAP2: view
genes like me logo Genes that share phenotypes with ADAP2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAP2 Gene

Localization for ADAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAP2 Gene

Cytoplasm. Cell membrane. Note=Constitutively associated with the plasma membrane. Excluded from the nucleus.

Subcellular locations from

Jensen Localization Image for ADAP2 Gene COMPARTMENTS Subcellular localization image for ADAP2 gene
Compartment Confidence
plasma membrane 5
mitochondrion 4
cytosol 3
nucleus 2
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for ADAP2 Gene

Pathways & Interactions for ADAP2 Gene

SuperPathways for ADAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADAP2 Gene


No data available for Pathways by source and SIGNOR curated interactions for ADAP2 Gene

Drugs & Compounds for ADAP2 Gene

No Compound Related Data Available

Transcripts for ADAP2 Gene

Unigene Clusters for ADAP2 Gene

ArfGAP with dual PH domains 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAP2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b
SP1: - -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: -

Relevant External Links for ADAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAP2 Gene

mRNA expression in normal human tissues for ADAP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAP2 Gene

This gene is overexpressed in Whole Blood (x5.5) and Spleen (x4.3).

Protein differential expression in normal tissues from HIPED for ADAP2 Gene

This gene is overexpressed in Spleen (39.1) and Placenta (29.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ADAP2 Gene

SOURCE GeneReport for Unigene cluster for ADAP2 Gene Hs.514063

mRNA Expression by UniProt/SwissProt for ADAP2 Gene

Tissue specificity: Highly expressed in placenta, spleen, kidney, skeletal muscle and adrenal gland. Weakly expressed in thyroid, liver, heart, lung, small intestine, peripheral blood leukocytes. Not detected in spinal cord, brain, stomach, trachea, colon, lymph node and bone marrow.
genes like me logo Genes that share expression patterns with ADAP2: view

Protein tissue co-expression partners for ADAP2 Gene

Primer Products

Orthologs for ADAP2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAP2 35
  • 88.01 (n)
  • 88.19 (a)
ADAP2 36
  • 87 (a)
(Canis familiaris)
Mammalia ADAP2 35
  • 89.5 (n)
  • 89.24 (a)
ADAP2 36
  • 89 (a)
(Mus musculus)
Mammalia Adap2 35
  • 86.65 (n)
  • 85.41 (a)
Adap2 16
Adap2 36
  • 85 (a)
(Pan troglodytes)
Mammalia ADAP2 35
  • 99.56 (n)
  • 99.21 (a)
ADAP2 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Adap2 35
  • 86.52 (n)
  • 84.31 (a)
(Monodelphis domestica)
Mammalia ADAP2 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ADAP2 36
  • 74 (a)
(Gallus gallus)
Aves ADAP2 35
  • 68.89 (n)
  • 64.72 (a)
ADAP2 36
  • 64 (a)
(Anolis carolinensis)
Reptilia ADAP2 36
  • 56 (a)
(Danio rerio)
Actinopterygii si:ch73-33i10.5 35
  • 60.74 (n)
  • 58.49 (a)
ADAP2 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8243 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea W09D10.1 36
  • 15 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE2 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8094 36
  • 40 (a)
Species with no ortholog for ADAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAP2 Gene

Gene Tree for ADAP2 (if available)
Gene Tree for ADAP2 (if available)

Paralogs for ADAP2 Gene

Paralogs for ADAP2 Gene

(8) SIMAP similar genes for ADAP2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ADAP2: view

Variants for ADAP2 Gene

Sequence variations from dbSNP and Humsavar for ADAP2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2135866 -- 30,945,397(-) GCACT(A/G)CTGCC intron-variant
rs1876430 -- 30,952,497(+) cagcc(C/T)cctga intron-variant
rs2232270 -- 30,922,068(+) GCGCC(A/G)GACAC reference, synonymous-codon
rs2232271 -- 30,923,083(+) GGCAT(C/G)CCCGT intron-variant
rs2232272 -- 30,944,814(+) TACAG(A/T)TTGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAP2 Gene

Variant ID Type Subtype PubMed ID
esv2715813 CNV Deletion 23290073
nsv457720 CNV Loss 19166990
nsv833412 CNV Loss 17160897

Variation tolerance for ADAP2 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.75% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADAP2 Gene

Disorders for ADAP2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ADAP2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
chromosome 17q11.2 deletion syndrome, 1.4mb
  • 17q11 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ADAP2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ADAP2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ADAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ADAP2 Gene

Publications for ADAP2 Gene

  1. Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins. (PMID: 14690521) Hanck T. … Reiser G. (J. Neurochem. 2004) 3 4 23 67
  2. Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval. (PMID: 16138909) Venturin M. … Riva P. (Ann. Hum. Genet. 2005) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry. (PMID: 26372645) Shu Q. … Coyne C.B. (PLoS Pathog. 2015) 3
  5. Centaurin-I+a88 interacts with I^-tubulin and stabilizes microtubules. (PMID: 23285209) Zuccotti P. … Riva P. (PLoS ONE 2012) 3

Products for ADAP2 Gene

Sources for ADAP2 Gene