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Aliases for ADAP1 Gene

Aliases for ADAP1 Gene

  • ArfGAP With Dual PH Domains 1 2 3 5
  • Putative MAPK-Activating Protein PM25 3 4
  • Centaurin, Alpha 1 2 3
  • Centaurin-Alpha-1 3 4
  • Cnt-A1 3 4
  • CENTA1 3 4
  • Centaurin-Alpha 3
  • P42IP4 3
  • GCS1L 3

External Ids for ADAP1 Gene

Previous HGNC Symbols for ADAP1 Gene

  • CENTA1

Previous GeneCards Identifiers for ADAP1 Gene

  • GC07M000905
  • GC07M000938

Summaries for ADAP1 Gene

GeneCards Summary for ADAP1 Gene

ADAP1 (ArfGAP With Dual PH Domains 1) is a Protein Coding gene. Among its related pathways are Class I PI3K signaling events and Arf6 signaling events. GO annotations related to this gene include GTPase activator activity and inositol 1,3,4,5 tetrakisphosphate binding. An important paralog of this gene is SMAP1.

UniProtKB/Swiss-Prot for ADAP1 Gene

  • GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Gene Wiki entry for ADAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAP1 Gene

Genomics for ADAP1 Gene

Regulatory Elements for ADAP1 Gene

Enhancers for ADAP1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAP1 on UCSC Golden Path with GeneCards custom track

Promoters for ADAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAP1 Gene

897,900 bp from pter
955,407 bp from pter
57,508 bases
Minus strand

Genomic View for ADAP1 Gene

Genes around ADAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAP1 Gene

Proteins for ADAP1 Gene

  • Protein details for ADAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with dual PH domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A4D2Q2
    • B3KRZ4
    • B4DVA6
    • F6XZ68
    • H7C2Q4

    Protein attributes for ADAP1 Gene

    374 amino acids
    Molecular mass:
    43395 Da
    Quaternary structure:
    • Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.

    Three dimensional structures from OCA and Proteopedia for ADAP1 Gene

    Alternative splice isoforms for ADAP1 Gene


neXtProt entry for ADAP1 Gene

Proteomics data for ADAP1 Gene at MOPED

Post-translational modifications for ADAP1 Gene

No data available for DME Specific Peptides for ADAP1 Gene

Domains & Families for ADAP1 Gene

Gene Families for ADAP1 Gene

Protein Domains for ADAP1 Gene

Suggested Antigen Peptide Sequences for ADAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Arf-GAP domain.
  • Contains 1 Arf-GAP domain.
  • Contains 2 PH domains.
genes like me logo Genes that share domains with ADAP1: view

Function for ADAP1 Gene

Molecular function for ADAP1 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Gene Ontology (GO) - Molecular Function for ADAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 10333475
genes like me logo Genes that share ontologies with ADAP1: view
genes like me logo Genes that share phenotypes with ADAP1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAP1 Gene

Localization for ADAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAP1 Gene

Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.

Subcellular locations from

Jensen Localization Image for ADAP1 Gene COMPARTMENTS Subcellular localization image for ADAP1 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytoskeleton 1
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for ADAP1 Gene

Pathways & Interactions for ADAP1 Gene

genes like me logo Genes that share pathways with ADAP1: view

Pathways by source for ADAP1 Gene

2 BioSystems pathways for ADAP1 Gene

Gene Ontology (GO) - Biological Process for ADAP1 Gene


No data available for SIGNOR curated interactions for ADAP1 Gene

Drugs & Compounds for ADAP1 Gene

(1) Drugs for ADAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for ADAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAP1: view

Transcripts for ADAP1 Gene

Unigene Clusters for ADAP1 Gene

ArfGAP with dual PH domains 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - -
SP5: -

Relevant External Links for ADAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAP1 Gene

mRNA expression in normal human tissues for ADAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAP1 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for ADAP1 Gene

This gene is overexpressed in Fetal Brain (15.1), Frontal cortex (12.8), Spinal cord (11.8), and Stomach (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ADAP1 Gene

SOURCE GeneReport for Unigene cluster for ADAP1 Gene Hs.602573

mRNA Expression by UniProt/SwissProt for ADAP1 Gene

Tissue specificity: Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.
genes like me logo Genes that share expression patterns with ADAP1: view

Primer Products

No data available for Protein tissue co-expression partners for ADAP1 Gene

Orthologs for ADAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ADAP1 35
  • 88.2 (n)
  • 90.88 (a)
ADAP1 36
  • 91 (a)
(Canis familiaris)
Mammalia ADAP1 35
  • 89.66 (n)
  • 93.58 (a)
ADAP1 36
  • 93 (a)
(Mus musculus)
Mammalia Adap1 35
  • 88.59 (n)
  • 94.12 (a)
Adap1 16
Adap1 36
  • 94 (a)
(Pan troglodytes)
Mammalia ADAP1 35
  • 99.64 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Adap1 35
  • 87.7 (n)
  • 93.85 (a)
(Monodelphis domestica)
Mammalia ADAP1 36
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia ADAP1 36
  • 76 (a)
(Gallus gallus)
Aves ADAP1 35
  • 78.7 (n)
  • 87.17 (a)
ADAP1 36
  • 87 (a)
(Anolis carolinensis)
Reptilia ADAP1 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100037843 35
  • 71.57 (n)
  • 79.41 (a)
MGC76109 35
African clawed frog
(Xenopus laevis)
Amphibia MGC69045 35
(Danio rerio)
Actinopterygii zgc:92360 35
  • 66.49 (n)
  • 62.4 (a)
CABZ01073174.1 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007379 35
  • 54.83 (n)
  • 43.09 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8243 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea W09D10.1 36
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE2 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8094 36
  • 41 (a)
Species with no ortholog for ADAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAP1 Gene

Gene Tree for ADAP1 (if available)
Gene Tree for ADAP1 (if available)

Paralogs for ADAP1 Gene

Paralogs for ADAP1 Gene

genes like me logo Genes that share paralogs with ADAP1: view

Variants for ADAP1 Gene

Sequence variations from dbSNP and Humsavar for ADAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10256887 - 900,544(+) GTCGC(C/T)GGCCC reference, missense
rs867479 -- 919,481(+) ACTCA(C/T)GAGTG intron-variant
rs1055738 -- 898,021(-) CCTGG(C/T)TGAGC utr-variant-3-prime
rs1055739 -- 897,949(-) CATCC(C/G)CCGCC utr-variant-3-prime
rs6950796 -- 930,460(+) atcac(A/G)aggtc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAP1 Gene

Variant ID Type Subtype PubMed ID
dgv7074n71 CNV Loss 21882294
dgv7078n71 CNV Loss 21882294
nsv887128 CNV Loss 21882294
nsv887134 CNV Loss 21882294
dgv7080n71 CNV Loss 21882294
nsv464244 CNV Loss 19166990
nsv509182 CNV Insertion 20534489
nsv5611 CNV Insertion 18451855
nsv464245 CNV Gain 19166990
nsv887137 CNV Gain 21882294
esv1065077 CNV Insertion 17803354
esv2733676 CNV Deletion 23290073
esv2733677 CNV Deletion 23290073
esv1457769 CNV Deletion 17803354
esv2733678 CNV Deletion 23290073
esv2733679 CNV Deletion 23290073
esv1134099 CNV Deletion 17803354
esv2733680 CNV Deletion 23290073
nsv887140 CNV Loss 21882294
nsv887141 CNV Loss 21882294
esv3420 CNV Deletion 18987735
esv2733681 CNV Deletion 23290073
esv1008204 CNV Deletion 20482838
esv1650528 CNV Deletion 17803354
esv997493 CNV Deletion 20482838
esv2733682 CNV Deletion 23290073
esv1298219 CNV Deletion 17803354
nsv366410 CNV Loss 16902084
nsv512903 CNV Insertion 21212237
esv2733684 CNV Deletion 23290073
esv2733685 CNV Deletion 23290073
esv1647726 CNV Deletion 17803354
esv2733686 CNV Deletion 23290073
esv2733687 CNV Deletion 23290073
esv2615886 CNV Insertion 19546169
nsv512904 CNV Insertion 21212237
esv22202 CNV Gain 19812545
esv1612925 CNV Deletion 17803354
nsv366941 CNV Insertion 16902084
esv29574 CNV Gain 19812545
esv1175595 CNV Deletion 17803354
esv2733688 CNV Deletion 23290073
esv1704339 CNV Deletion 17803354
nsv887142 CNV Gain 21882294
esv1449576 CNV Insertion 17803354
nsv511937 CNV Loss 21212237
esv2733689 CNV Deletion 23290073
esv2733690 CNV Deletion 23290073
esv2733691 CNV Deletion 23290073
esv2733692 CNV Deletion 23290073
dgv7081n71 CNV Loss 21882294
dgv7082n71 CNV Loss 21882294
dgv7083n71 CNV Loss 21882294
esv22922 CNV Loss 19812545

Variation tolerance for ADAP1 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ADAP1 Gene

Disorders for ADAP1 Gene

Relevant External Links for ADAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAP1 Gene

Publications for ADAP1 Gene

  1. Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. (PMID: 10333475) Venkateswarlu K. … Cullen P.J. (Biochem. J. 1999) 2 3 4 23 67
  2. Centaurin-alpha 1, an ADP-ribosylation factor 6 GTPase activating protein, inhibits beta 2-adrenoceptor internalization. (PMID: 15778454) Lawrence J. … Venkateswarlu K. (Mol. Pharmacol. 2005) 3 23
  3. p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor. (PMID: 16341594) Sedehizade F. … Reiser G. (Neurochem. Res. 2005) 3 23
  4. Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins. (PMID: 14690521) Hanck T. … Reiser G. (J. Neurochem. 2004) 3 23
  5. Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin. (PMID: 15106847) Reiser G. … Bernstein H.G. (Neuroreport 2004) 3 23

Products for ADAP1 Gene

Sources for ADAP1 Gene