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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAP1 Gene

protein-coding   GIFtS: 57
GCID: GC07M000905

ArfGAP With Dual PH Domains 1

(Previous names: centaurin, alpha 1)
(Previous symbol: CENTA1)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ArfGAP With Dual PH Domains 11 2     centaurin-alpha2
CENTA11 2 3 5     centaurin-alpha-12
Centaurin, Alpha 11 2     cnt-a12
Putative MAPK-Activating Protein PM252 3     p42IP42
GCS1L2     Centaurin-alpha-13
Arf-GAP With Dual PH Domain-Containing Protein 12     Cnt-a13

External Ids:    HGNC: 164861   Entrez Gene: 110332   Ensembl: ENSG000001059637   OMIM: 6081145   UniProtKB: O756893   

Export aliases for ADAP1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ADAP1 Gene: 
ADAP1 (ArfGAP with dual PH domains 1) is a protein-coding gene. Diseases associated with ADAP1 include alzheimer's disease, and meningioma. GO annotations related to this gene include phospholipid binding and inositol 1,3,4,5 tetrakisphosphate binding. An important paralog of this gene is SMAP1.

UniProtKB/Swiss-Prot: ADAP1_HUMAN, O75689
Function: GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol
3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4)

Gene Wiki entry for ADAP1 (Centaurin, alpha 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAP1 gene promoter:
         c-Fos   AP-1   deltaCREB   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): ADAP1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAP1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3   Ensembl cytogenetic band:  7p22.3   HGNC cytogenetic band: 7p22.3

ADAP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAP1 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M000905:  view genomic region     (about GC identifiers)

Start:
937,537 bp from pter      End:
995,043 bp from pter
Size:
57,507 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 992,062-1,048,924     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ADAP1_HUMAN, O75689 (See protein sequence)
Recommended Name: Arf-GAP with dual PH domain-containing protein 1  
Size: 374 amino acids; 43395 Da
Subunit: Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1
Subcellular location: Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth
factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase
4 PDB 3D structures from and Proteopedia for ADAP1:
3FEH (3D)        3FM8 (3D)        3LJU (3D)        3MDB (3D)    
Secondary accessions: A4D2Q2

Explore the universe of human proteins at neXtProt for ADAP1: NX_O75689

Explore proteomics data for ADAP1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by PRKCA, PRKCI, PRKCZ and PRKD1 in vitro
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O75689

  • ADAP1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ADAP1 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001271237.1  NP_001271238.1  NP_001271239.1  NP_001271240.1  NP_006860.1  

    ENSEMBL proteins: 
     ENSP00000265846   ENSP00000414436   ENSP00000409129   ENSP00000404217   ENSP00000391315  
     ENSP00000416545   ENSP00000394973   ENSP00000442682   ENSP00000407267  

    Human Recombinant Protein Products for ADAP1: 
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    Novus Biologicals ADAP1 Protein
    Novus Biologicals ADAP1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA10333475
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA10333475

    ADAP1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ArfGAP: ADP-ribosylation factor GTPase activating proteins

    3 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR001164 ArfGAP
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry O75689

    ProtoNet protein and cluster: O75689

    2 Blocks protein domains:
    IPB001164 HIV Rev interacting protein signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ADAP1_HUMAN, O75689
    Similarity: Contains 1 Arf-GAP domain
    Similarity: Contains 2 PH domains


    ADAP1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ADAP1_HUMAN, O75689
    Function: GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol
    3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12893243
    GO:0005543phospholipid binding IEA--
    GO:0008060ARF GTPase activator activity IDA10333475
    GO:0008270zinc ion binding IEA--
    GO:0043533inositol 1,3,4,5 tetrakisphosphate binding TAS12018390
         
    ADAP1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ADAP1:
     Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ADAP1 
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    SwitchGear 3'UTR luciferase reporter plasmidADAP1 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAP1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ADAP1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Arf6 signaling events
    Arf6 signaling events
    2Class I PI3K signaling events
    Class I PI3K signaling events


    2 BioSystems Pathways for ADAP1
        Arf6 signaling events
    Class I PI3K signaling events



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ADAP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/24 Interacting proteins for ADAP1 (O756892, 3 ENSP000002658464) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GADD45AP245222, 3MINT-8255672 I2D: score=2 
    GSK3BP498412, 3MINT-8256866 I2D: score=2 
    CSNK1A1P487292, 3, ENSP000002617984MINT-13946 I2D: score=3 STRING: ENSP00000261798
    PSME3P612892, 3, ENSP000002933624MINT-63934 I2D: score=5 STRING: ENSP00000293362
    PRKCEQ021563, ENSP000003061244I2D: score=3 STRING: ENSP00000306124
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007166cell surface receptor signaling pathway TAS10333475
    GO:0032312regulation of ARF GTPase activity IEA--
    GO:0043087regulation of GTPase activity IMP10333475

    ADAP1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ADAP1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAP1

    4 Novoseek inferred chemical compound relationships for ADAP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    inositol 1,3,4,5-tetrakisphosphate 86.4 4 10504414 (1), 8920956 (1), 16341594 (1)
    phosphatidylinositol-3,4,5-trisphosphate 71.7 1 16341594 (1)
    phosphatidylinositol 43 2 10504414 (1), 11278595 (1)
    lipid 9.06 2 10504414 (1), 10333475 (1)

    Search CenterWatch for drugs/clinical trials and news about ADAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAP1 gene (5 alternative transcripts): 
    NM_001284308.1  NM_001284309.1  NM_001284310.1  NM_001284311.1  NM_006869.3  

    Unigene Cluster for ADAP1:

    ArfGAP with dual PH domains 1
    Hs.602573  [show with all ESTs]
    Unigene Representative Sequence: AF082324
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265846(uc010ksc.3 uc011jvs.2 uc003sjo.4) ENST00000446141
    ENST00000478000(uc003sjm.4) ENST00000495809 ENST00000453175 ENST00000437486
    ENST00000454383 ENST00000453823 ENST00000481406 ENST00000463358 ENST00000477906
    ENST00000488527 ENST00000435943 ENST00000495686 ENST00000539900 ENST00000449296(uc003sjn.4)


    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAP1:
    hsa-miR-525-5p hsa-miR-520a-5p
    SwitchGear 3'UTR luciferase reporter plasmidADAP1 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAP1

    Additional mRNA sequence: 

    AB097049.1 AF082324.1 AJ006422.1 AK092471.1 AK124979.1 AK290517.1 AK300644.1 AK300859.1 
    AK300999.1 BC033747.1 

    16 DOTS entries:

    DT.300046  DT.433398  DT.100805530  DT.101962463  DT.100805531  DT.100757913  DT.100805529  DT.121061443 
    DT.121061470  DT.91744243  DT.95272377  DT.100805522  DT.100805523  DT.121061488  DT.75183695  DT.95272379 

    24/127 AceView cDNA sequences (see all 127):

    CR619954 BQ880482 AI979212 BX283430 BM842644 CR625461 BM760690 BC033747 
    AI910700 CB145207 BX282097 BQ691205 CB154780 BM761001 CB156614 BM842888 
    CD514996 BU728010 CR607974 BX354869 NM_006869 CB154994 BM686645 BX340467 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ADAP1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:              -     -           -                                                               
    SP2:                    -           -                                                               
    SP3:                                                                                                
    SP4:                                                                                                
    SP5:                                -                                                               


    ECgene alternative splicing isoforms for ADAP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAP1 expression in normal human tissues (normalized intensities)      ADAP1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAP1 Expression
    About this image


    ADAP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             umbilical cord reticulocytes   
     
     Umbilical Cord (Extraembryonic Tissues)
             umbilical cord reticulocytes   
     
     Endothelium (Cardiovascular System)
             Peripheral blood-derived early endothelial progenitor cells
     
     Amnion (Extraembryonic Tissues)
             Human Amniotic Mesenchymal Stromal Cells (HAmMSC)   

    See ADAP1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAP1

    SOURCE GeneReport for Unigene cluster: Hs.602573

    UniProtKB/Swiss-Prot: ADAP1_HUMAN, O75689
    Tissue specificity: Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes

        SABiosciences Custom PCR Arrays for ADAP1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAP1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ADAP1 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adap11 , 5 ArfGAP with dual PH domains 11, 5 88.59(n)1
    94.12(a)1
      5 (78.27 cM)5
    2318211  NM_172723.41  NP_766311.21 
     1392718765 
    chicken
    (Gallus gallus)
    Aves ADAP11 ArfGAP with dual PH domains 1 78.7(n)
    87.17(a)
      416451  XM_414759.3  XP_414759.2 
    lizard
    (Anolis carolinensis)
    Reptilia ADAP16
    Uncharacterized protein
    84(a)
    1 ↔ 1
    GL343385.1(700091-720552)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC690452 hypothetical protein MGC69045 77.62(n)    BC059321.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:923601 zgc:92360 66.3(n)
    62.4(a)
      436988  NM_001002715.1  NP_001002715.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0073791 AGAP007379-PA 54.74(n)
    43.09(a)
      1269802  XM_308452.4  XP_308452.4 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes AGE26
    ADP-ribosylation factor (ARF) GTPase activating pr...
    22(a)
    1 → many
    IX(272950-273846)


    ENSEMBL Gene Tree for ADAP1 (if available)
    TreeFam Gene Tree for ADAP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAP1 gene
    SMAP12  SMAP22  ADAP22  
    8 SIMAP similar genes for ADAP1 using alignment to 9 protein entries:     ADAP1_HUMAN (see all proteins):
    ADAP2    CENTA2    AGAP3    ARFGAP3    AGAP1    SMAP1
    AGAP8    ARFGAP1

    ADAP1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2271 SNPs in ADAP1 are shown (see all 2271)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0474704
    ----see VAR_0474702 G S mis40--------
    rs1469624021,2
    --937057(+) CTAGGC/TTGGGA 1 -- ds50010--------
    rs599086211,2
    C,F--937189(+) CCCCCG/TACCCG 1 -- ds50013Minor allele frequency- T:0.43WA NA EA 358
    rs1921196001,2
    --937205(+) CATCCC/TCCACA 1 -- ds50010--------
    rs1818089031,2
    --937296(+) GGGCAC/TCTGGG 1 -- ds50010--------
    rs1414038861,2
    --937305(+) GGAAG-/GG    
       GTGCT
    GGGGG
    1 -- ds50010--------
    rs1395650351,2
    C--937322(+) GGGAA-/GGG   
       GTGCT
    GGGGG
    1 -- ds50010--------
    rs772505681,2
    C,F--937341(+) CACCTC/TGGGTA 1 -- ds50013Minor allele frequency- T:0.04WA NA EA 358
    rs1852077801,2
    C--937353(+) GGACCA/GTCTCC 1 -- ds50010--------
    rs1895803401,2
    --937355(+) ACCGTC/TTCCCG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ADAP1 (937537 - 995043 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/54 variations for ADAP1 (see all 54):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733679CNV Deletion23290073
    esv2733692CNV Deletion23290073
    esv2733688CNV Deletion23290073
    esv2733689CNV Deletion23290073
    esv2733676CNV Deletion23290073
    esv2733682CNV Deletion23290073
    esv1650528CNV Deletion17803354
    esv1175595CNV Deletion17803354
    esv2733691CNV Deletion23290073
    esv2733680CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608114    OMIM disorders: --

    5 diseases for ADAP1:    About MalaCards
    alzheimer's disease    meningioma    neuroblastoma    neuronitis
    leukemia


    ADAP1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    2 Novoseek inferred disease relationships for ADAP1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    senile plaques 46.1 1 15106847 (1)
    alzheimers disease 12.9 3 12499840 (1), 15106847 (1)

    Genetic Association Database (GAD): ADAP1
    Human Genome Epidemiology (HuGE) Navigator: ADAP1 (4 documents)

    Export disorders for ADAP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAP1 gene, integrated from 9 sources (see all 41):
    (articles sorted by number of sources associating them with ADAP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. (PubMed id 10333475)1, 2, 3, 9 Venkateswarlu K.... Cullen P.J. (1999)
    2. Molecular cloning and functional characterization of a human homologue of centaurin-alpha. (PubMed id 10448098)1, 2, 9 Venkateswarlu K. and Cullen P.J. (1999)
    3. Risk of meningioma and common variation in genes rela ted to innate immunity. (PubMed id 20406964)1, 4 Rajaraman P....Inskip P.D. (2010)
    4. Polymorphisms in innate immunity genes and risk of ch ildhood leukemia. (PubMed id 20438785)1, 4 Han S....Kang D. (2010)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C. (PubMed id 12893243)1, 2 Zemlickova E.... Aitken A. (2003)
    7. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PubMed id 12761501)1, 2 Matsuda A....Sugano S. (2003)
    8. Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins. (PubMed id 14690521)1, 9 Hanck T.... Reiser G. (2004)
    9. Neurons and plaques of Alzheimer's disease patients highly express the neuronal membrane docking protein p42IP4/centaurin alpha. (PubMed id 12499840)1, 9 Reiser G. and Bernstein H.G. (2002)
    10. p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor. (PubMed id 16341594)1, 9 Sedehizade F....Reiser G. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11033 HGNC: 16486 AceView: CENTA1 Ensembl:ENSG00000105963 euGenes: HUgn11033
    ECgene: ADAP1 H-InvDB: ADAP1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAP1 gene:
    Search GeneIP for patents involving ADAP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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