Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAP1 Gene

Aliases for ADAP1 Gene

  • ArfGAP With Dual PH Domains 1 2 3 5
  • Putative MAPK-Activating Protein PM25 3 4
  • Centaurin-Alpha-1 3 4
  • Cnt-A1 3 4
  • CENTA1 3 4
  • Arf-GAP With Dual PH Domain-Containing Protein 1 3
  • Centaurin, Alpha 1 2
  • Centaurin-Alpha 3
  • P42IP4 3
  • GCS1L 3

External Ids for ADAP1 Gene

Previous HGNC Symbols for ADAP1 Gene

  • CENTA1

Previous GeneCards Identifiers for ADAP1 Gene

  • GC07M000905
  • GC07M000938

Summaries for ADAP1 Gene

GeneCards Summary for ADAP1 Gene

ADAP1 (ArfGAP With Dual PH Domains 1) is a Protein Coding gene. Among its related pathways are Arf6 signaling events and B Cell Receptor Signaling Pathway (sino). GO annotations related to this gene include GTPase activator activity and inositol 1,3,4,5 tetrakisphosphate binding. An important paralog of this gene is ADAP2.

UniProtKB/Swiss-Prot for ADAP1 Gene

  • GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Gene Wiki entry for ADAP1 Gene

Additional gene information for ADAP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAP1 Gene

Genomics for ADAP1 Gene

Regulatory Elements for ADAP1 Gene

Enhancers for ADAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H000921 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.8 +28.7 28650 10.5 HDGF MLX ARID4B DMAP1 ZBTB7B TCF12 ZNF143 ZNF207 FOS ATF7 ADAP1 LOC105375120 CYP2W1 ZFAND2A LOC101927021 C7orf50 COX19 PIR34198 GC07P000891
GH07H000906 1.8 FANTOM5 Ensembl ENCODE dbSUPER 16.4 +45.6 45591 5.8 HDGF PKNOX1 RB1 SIN3A ZNF2 RAD21 GLIS2 EGR1 ZNF143 RUNX3 ADAP1 LOC105375120 ZFAND2A LOC101927021 COX19 GC07P000891 PIR34198
GH07H000828 1.5 Ensembl ENCODE dbSUPER 16.7 +123.6 123559 6 PKNOX1 ATF1 ATF7 FOS RUNX3 JUNB TSHZ1 REST SMARCB1 MEF2D ADAP1 DNAAF5 PRKAR1B SUN1 ENSG00000273151 PIR52165
GH07H000971 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -20.8 -20837 8.8 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CYP2W1 SUN1 DNAAF5 LOC105375120 GPR146 MIR339 ADAP1 ENSG00000225146 C7orf50 INTS1
GH07H000981 1.5 Ensembl ENCODE dbSUPER 12.3 -29.9 -29892 7.1 HDGF MLX ARID4B DMAP1 ZBTB7B TCF12 ZNF121 GLIS2 FOS MXD4 CYP2W1 LOC105375120 GPR146 MIR339 ADAP1 COX19 ENSG00000225146 C7orf50 LOC101927021 GC07M001007
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ADAP1 on UCSC Golden Path with GeneCards custom track

Promoters for ADAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207516 1107 1001 RB1 ZFP64 ARID4B SIN3A DMAP1 RAD21 GLIS2 ELK1 ZNF143 ATF7

Genomic Locations for ADAP1 Gene

Genomic Locations for ADAP1 Gene
57,508 bases
Minus strand

Genomic View for ADAP1 Gene

Genes around ADAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAP1 Gene

Proteins for ADAP1 Gene

  • Protein details for ADAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Arf-GAP with dual PH domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A4D2Q2
    • B3KRZ4
    • B4DVA6
    • F6XZ68
    • H7C2Q4

    Protein attributes for ADAP1 Gene

    374 amino acids
    Molecular mass:
    43395 Da
    Quaternary structure:
    • Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.

    Three dimensional structures from OCA and Proteopedia for ADAP1 Gene

    Alternative splice isoforms for ADAP1 Gene


neXtProt entry for ADAP1 Gene

Post-translational modifications for ADAP1 Gene

No data available for DME Specific Peptides for ADAP1 Gene

Domains & Families for ADAP1 Gene

Gene Families for ADAP1 Gene

Protein Domains for ADAP1 Gene

Suggested Antigen Peptide Sequences for ADAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ADAP1: view

No data available for UniProtKB/Swiss-Prot for ADAP1 Gene

Function for ADAP1 Gene

Molecular function for ADAP1 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).

Phenotypes From GWAS Catalog for ADAP1 Gene

Gene Ontology (GO) - Molecular Function for ADAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 10333475
GO:0005515 protein binding IPI 12893243
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IEA --
GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding TAS 12018390
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ADAP1: view
genes like me logo Genes that share phenotypes with ADAP1: view

Clone Products

  • Addgene plasmids for ADAP1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ADAP1 Gene

Localization for ADAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAP1 Gene

Nucleus. Cytoplasm. Note=Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ADAP1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ADAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10333475
GO:0005737 cytoplasm IEA,IDA 10333475
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA 10333475
genes like me logo Genes that share ontologies with ADAP1: view

Pathways & Interactions for ADAP1 Gene

genes like me logo Genes that share pathways with ADAP1: view

Pathways by source for ADAP1 Gene

1 Sino Biological pathway for ADAP1 Gene
2 BioSystems pathways for ADAP1 Gene

Gene Ontology (GO) - Biological Process for ADAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007166 cell surface receptor signaling pathway TAS 10333475
GO:0043087 regulation of GTPase activity IMP 10333475
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ADAP1: view

No data available for SIGNOR curated interactions for ADAP1 Gene

Drugs & Compounds for ADAP1 Gene

(1) Drugs for ADAP1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for ADAP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ADAP1: view

Transcripts for ADAP1 Gene

Unigene Clusters for ADAP1 Gene

ArfGAP with dual PH domains 1:
Representative Sequences:

Clone Products

  • Addgene plasmids for ADAP1

Alternative Splicing Database (ASD) splice patterns (SP) for ADAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - -
SP5: -

Relevant External Links for ADAP1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ADAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAP1 Gene

This gene is overexpressed in Whole Blood (x4.9).

Protein differential expression in normal tissues from HIPED for ADAP1 Gene

This gene is overexpressed in Fetal Brain (15.1), Frontal cortex (12.8), Spinal cord (11.8), and Stomach (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ADAP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of ADAP1 Gene:


SOURCE GeneReport for Unigene cluster for ADAP1 Gene:


mRNA Expression by UniProt/SwissProt for ADAP1 Gene:

Tissue specificity: Expressed at highest levels in brain and at lower levels in peripheral blood leukocytes.

Evidence on tissue expression from TISSUES for ADAP1 Gene

  • Intestine(4)
  • Lung(4)
genes like me logo Genes that share expression patterns with ADAP1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ADAP1 Gene

Orthologs for ADAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ADAP1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ADAP1 33
  • 99.64 (n)
(Monodelphis domestica)
Mammalia ADAP1 34
  • 90 (a)
(Canis familiaris)
Mammalia ADAP1 33 34
  • 89.66 (n)
(Mus musculus)
Mammalia Adap1 33 16 34
  • 88.59 (n)
(Bos Taurus)
Mammalia ADAP1 33 34
  • 88.2 (n)
(Rattus norvegicus)
Mammalia Adap1 33
  • 87.7 (n)
(Ornithorhynchus anatinus)
Mammalia ADAP1 34
  • 76 (a)
(Gallus gallus)
Aves ADAP1 33 34
  • 78.7 (n)
(Anolis carolinensis)
Reptilia ADAP1 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100037843 33
  • 71.57 (n)
MGC76109 33
African clawed frog
(Xenopus laevis)
Amphibia MGC69045 33
(Danio rerio)
Actinopterygii CABZ01073174.1 34
  • 78 (a)
zgc:92360 33
  • 66.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007379 33
  • 54.83 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8243 34
  • 14 (a)
(Caenorhabditis elegans)
Secernentea W09D10.1 34
  • 16 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes AGE2 34
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8094 34
  • 41 (a)
Species where no ortholog for ADAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ADAP1 Gene

Gene Tree for ADAP1 (if available)
Gene Tree for ADAP1 (if available)

Paralogs for ADAP1 Gene

Paralogs for ADAP1 Gene

genes like me logo Genes that share paralogs with ADAP1: view

Variants for ADAP1 Gene

Sequence variations from dbSNP and Humsavar for ADAP1 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000026463 -- 943,989(+) TGGCT(A/C)ACTGC intron-variant
rs1000029894 -- 949,277(+) CTCCT(-/GGCCACAC)GGCCA intron-variant
rs1000047401 -- 916,585(+) GGAGC(A/G)AGGGG intron-variant
rs1000057515 -- 944,757(+) AAGTA(C/T)AATAA intron-variant
rs1000078359 -- 931,928(+) TCCCC(A/G)CTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAP1 Gene

Variant ID Type Subtype PubMed ID
esv6292 CNV loss 19470904
esv997493 CNV deletion 20482838
nsv1073623 CNV deletion 25765185
nsv1073624 CNV deletion 25765185
nsv1073625 CNV deletion 25765185
nsv1073626 CNV deletion 25765185
nsv1078839 CNV insertion 25765185
nsv1114904 CNV deletion 24896259
nsv1114905 CNV deletion 24896259
nsv1117688 CNV deletion 24896259
nsv1124156 CNV deletion 24896259
nsv1125904 CNV tandem duplication 24896259
nsv1126089 CNV deletion 24896259
nsv1133395 CNV tandem duplication 24896259
nsv1133643 CNV deletion 24896259
nsv1137183 CNV deletion 24896259
nsv1140200 CNV insertion 24896259
nsv1143179 CNV tandem duplication 24896259
esv3891008 CNV loss 25118596
esv3611796 CNV gain 21293372
esv3571558 CNV loss 25503493
esv3571557 CNV loss 25503493
esv3420 CNV loss 18987735
esv29574 CNV gain 19812545
esv2733692 CNV deletion 23290073
esv2733691 CNV deletion 23290073
esv2733690 CNV deletion 23290073
esv2733689 CNV deletion 23290073
esv2733688 CNV deletion 23290073
esv2733687 CNV deletion 23290073
esv2733686 CNV deletion 23290073
esv2733685 CNV deletion 23290073
esv2733684 CNV deletion 23290073
esv2733682 CNV deletion 23290073
esv2733681 CNV deletion 23290073
esv2733680 CNV deletion 23290073
esv2733679 CNV deletion 23290073
esv2733678 CNV deletion 23290073
esv2733677 CNV deletion 23290073
esv2733676 CNV deletion 23290073
esv2615886 CNV insertion 19546169
esv22922 CNV loss 19812545
esv22202 CNV gain 19812545
esv1704339 CNV deletion 17803354
esv1650528 CNV deletion 17803354
esv1647726 CNV deletion 17803354
esv1612925 CNV deletion 17803354
esv1457769 CNV deletion 17803354
esv1449576 CNV insertion 17803354
esv1298219 CNV deletion 17803354
esv1175595 CNV deletion 17803354
esv1134099 CNV deletion 17803354
esv1065077 CNV insertion 17803354
esv1008204 CNV deletion 20482838
dgv3733e59 CNV duplication 20981092
dgv3732e59 CNV duplication 20981092
dgv11115n54 CNV loss 21841781
dgv11114n54 CNV gain 21841781
dgv11113n54 CNV gain 21841781
dgv11112n54 CNV loss 21841781
dgv11111n54 CNV loss 21841781
nsv950784 CNV deletion 24416366
nsv605714 CNV gain+loss 21841781
nsv605706 CNV loss 21841781
nsv605705 CNV loss 21841781
nsv605704 CNV gain 21841781
nsv605703 CNV loss 21841781
nsv605702 CNV loss 21841781
nsv605700 CNV gain 21841781
nsv605699 CNV loss 21841781
nsv5611 CNV insertion 18451855
nsv512904 CNV insertion 21212237
nsv512903 CNV insertion 21212237
nsv511937 CNV loss 21212237
nsv509182 CNV insertion 20534489
nsv475830 CNV novel sequence insertion 20440878
nsv464245 CNV gain 19166990
nsv464244 CNV loss 19166990
nsv366941 CNV insertion 16902084
nsv366410 CNV deletion 16902084
nsv1161477 CNV deletion 26073780
nsv1152364 CNV insertion 26484159
nsv1146694 CNV deletion 26484159
nsv1145118 CNV deletion 24896259

Variation tolerance for ADAP1 Gene

Residual Variation Intolerance Score: 18.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAP1 Gene

Disorders for ADAP1 Gene

Relevant External Links for ADAP1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ADAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAP1 Gene

Publications for ADAP1 Gene

  1. Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1. (PMID: 10333475) Venkateswarlu K … Cullen PJ (The Biochemical journal 1999) 2 3 4 22 60
  2. Molecular cloning and functional characterization of a human homologue of centaurin-alpha. (PMID: 10448098) Venkateswarlu K … Cullen PJ (Biochemical and biophysical research communications 1999) 3 4 22 60
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 45 60
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 45 60
  5. p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor. (PMID: 16341594) Sedehizade F … Reiser G (Neurochemical research 2005) 3 22 60

Products for ADAP1 Gene

  • Addgene plasmids for ADAP1

Sources for ADAP1 Gene

Loading form....