Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ADAMTSL5 Gene

Aliases for ADAMTSL5 Gene

  • ADAMTS-Like 5 2 3
  • Thrombospondin Type-1 Domain-Containing Protein 6 3 4
  • Thrombospondin, Type I, Domain Containing 6 2 3
  • ADAMTSL-5 3 4
  • THSD6 3 4
  • ADAMTS-Like Protein 5 3

External Ids for ADAMTSL5 Gene

Previous HGNC Symbols for ADAMTSL5 Gene

  • THSD6

Previous GeneCards Identifiers for ADAMTSL5 Gene

  • GC19M001460
  • GC19M001279

Summaries for ADAMTSL5 Gene

GeneCards Summary for ADAMTSL5 Gene

ADAMTSL5 (ADAMTS-Like 5) is a Protein Coding gene. GO annotations related to this gene include heparin binding and metalloendopeptidase activity. An important paralog of this gene is ADAMTSL1.

UniProtKB/Swiss-Prot for ADAMTSL5 Gene

  • May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM)

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTSL5 Gene

Genomics for ADAMTSL5 Gene

Regulatory Elements for ADAMTSL5 Gene

Genomic Location for ADAMTSL5 Gene

1,505,018 bp from pter
1,513,604 bp from pter
8,587 bases
Minus strand

Genomic View for ADAMTSL5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ADAMTSL5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTSL5 Gene

Proteins for ADAMTSL5 Gene

  • Protein details for ADAMTSL5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADAMTS-like protein 5
    Protein Accession:
    Secondary Accessions:
    • B4DXK7
    • Q8IW95

    Protein attributes for ADAMTSL5 Gene

    481 amino acids
    Molecular mass:
    53193 Da
    Quaternary structure:
    • Interacts with heparin, FBN1 and FBN2.

    Alternative splice isoforms for ADAMTSL5 Gene


neXtProt entry for ADAMTSL5 Gene

Proteomics data for ADAMTSL5 Gene at MOPED

Post-translational modifications for ADAMTSL5 Gene

  • Contains at least one additional N-linked glycosylation site.
  • Proteolytically cleaved to release a C-terminal fragment containing the NTR domain
  • Glycosylation at Asn218

Other Protein References for ADAMTSL5 Gene

Antibody Products

No data available for DME Specific Peptides for ADAMTSL5 Gene

Domains for ADAMTSL5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q6ZMM2
  • Contains 1 NTR domain.
  • Contains 1 TSP type-1 domain.
genes like me logo Genes that share domains with ADAMTSL5: view

No data available for Gene Families for ADAMTSL5 Gene

Function for ADAMTSL5 Gene

Molecular function for ADAMTSL5 Gene

UniProtKB/Swiss-Prot Function:
May play a role in modulation of fibrillin microfibrils in the extracellular matrix (ECM)

Gene Ontology (GO) - Molecular Function for ADAMTSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008201 heparin binding IDA 23010571
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with ADAMTSL5: view

Phenotypes for ADAMTSL5 Gene

GenomeRNAi human phenotypes for ADAMTSL5:
genes like me logo Genes that share phenotypes with ADAMTSL5: view

Animal Model Products

miRNA for ADAMTSL5 Gene

miRTarBase miRNAs that target ADAMTSL5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTSL5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ADAMTSL5 Gene

Localization for ADAMTSL5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTSL5 Gene

Secreted. Secreted, extracellular space, extracellular matrix. Note=Colocalized with fibrillin microfibrils. Predominantly distributed in baso-lateral regions of fibroblast extracellular matrix.

Subcellular locations from

Jensen Localization Image for ADAMTSL5 Gene COMPARTMENTS Subcellular localization image for ADAMTSL5 gene
Compartment Confidence
extracellular 3
nucleus 3
cytosol 2
lysosome 2

Gene Ontology (GO) - Cellular Components for ADAMTSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001527 colocalizes_with microfibril IDA 23010571
GO:0005576 extracellular region IDA 23010571
GO:0005578 proteinaceous extracellular matrix IDA 23010571
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with ADAMTSL5: view

Pathways for ADAMTSL5 Gene

SuperPathways for ADAMTSL5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ADAMTSL5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with ADAMTSL5: view

No data available for Pathways by source for ADAMTSL5 Gene

Transcripts for ADAMTSL5 Gene

Unigene Clusters for ADAMTSL5 Gene

ADAMTS-like 5:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ADAMTSL5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTSL5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - -
SP2: - -
SP3: - -

Relevant External Links for ADAMTSL5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ADAMTSL5 Gene

mRNA expression in normal human tissues for ADAMTSL5 Gene

mRNA differential expression in normal tissues according to GTEx for ADAMTSL5 Gene

This gene is overexpressed in Cervix - Ectocervix (5.7), Vagina (5.3), and Heart - Left Ventricle (4.4).

Protein differential expression in normal tissues for ADAMTSL5 Gene

This gene is overexpressed in Testis (49.9) and Rectum (11.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ADAMTSL5 Gene

SOURCE GeneReport for Unigene cluster for ADAMTSL5 Gene Hs.371674

genes like me logo Genes that share expressions with ADAMTSL5: view

Expression partners for ADAMTSL5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ADAMTSL5 Gene

Orthologs for ADAMTSL5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ADAMTSL5 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia ADAMTSL5 35
  • 85.13 (n)
  • 83.63 (a)
  • 78 (a)
(Mus musculus)
Mammalia Adamtsl5 35
  • 79.37 (n)
  • 80.52 (a)
Adamtsl5 16
Adamtsl5 36
  • 78 (a)
(Pan troglodytes)
Mammalia ADAMTSL5 35
  • 98.51 (n)
  • 97.88 (a)
  • 95 (a)
(Rattus norvegicus)
Mammalia Adamtsl5 35
  • 82.21 (n)
  • 84.46 (a)
(Bos Taurus)
Mammalia -- 36
  • 79 (a)
-- 36
  • 79 (a)
(Monodelphis domestica)
Mammalia ADAMTSL5 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia ADAMTSL5 36
  • 57 (a)
(Gallus gallus)
Aves ADAMTSL5 35
  • 63.88 (n)
  • 53.72 (a)
  • 51 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 6 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487633 35
  • 49.47 (n)
  • 43.64 (a)
(Danio rerio)
Actinopterygii CR382298.3 36
  • 33 (a)
Species with no ortholog for ADAMTSL5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ADAMTSL5 Gene

Gene Tree for ADAMTSL5 (if available)
Gene Tree for ADAMTSL5 (if available)

Paralogs for ADAMTSL5 Gene

Selected SIMAP similar genes for ADAMTSL5 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ADAMTSL5: view

Variants for ADAMTSL5 Gene

Sequence variations from dbSNP and Humsavar for ADAMTSL5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs197198 -- 1,505,875(+) GTGTG(A/C/G/T)GGGAG utr-variant-3-prime
rs265290 -- 1,512,094(+) GAAAG(A/C/G/T)GGGGG intron-variant, upstream-variant-2KB
rs265291 -- 1,510,662(+) CGCAC(A/G)GAGAC synonymous-codon, reference, utr-variant-5-prime, upstream-variant-2KB
rs265292 -- 1,510,528(+) GCGGG(A/T)TCAGG intron-variant, upstream-variant-2KB
rs265293 -- 1,509,626(+) gaagg(A/G)aggga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ADAMTSL5 Gene

Variant ID Type Subtype PubMed ID
nsv910292 CNV Loss 21882294
dgv1055e1 CNV Complex 17122850
dgv3580n71 CNV Loss 21882294
dgv3583n71 CNV Loss 21882294
dgv3589n71 CNV Loss 21882294
dgv3596n71 CNV Loss 21882294
esv32942 CNV Gain+Loss 17666407
dgv3598n71 CNV Loss 21882294
nsv910491 CNV Gain+Loss 21882294
dgv3599n71 CNV Loss 21882294
essv18235 CNV CNV 17122850
nsv833705 CNV Loss 17160897
nsv910499 CNV Loss 21882294
dgv3600n71 CNV Loss 21882294
dgv3601n71 CNV Loss 21882294
dgv3602n71 CNV Loss 21882294
dgv3603n71 CNV Loss 21882294
nsv470105 CNV Gain 18288195
dgv3604n71 CNV Gain+Loss 21882294
nsv470106 CNV Loss 18288195
nsv910521 CNV Loss 21882294
dgv3606n71 CNV Loss 21882294
dgv3607n71 CNV Loss 21882294
dgv3608n71 CNV Loss 21882294
dgv3609n71 CNV Loss 21882294

Relevant External Links for ADAMTSL5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTSL5 Gene

Disorders for ADAMTSL5 Gene

Relevant External Links for ADAMTSL5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for ADAMTSL5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for ADAMTSL5 Gene

Publications for ADAMTSL5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2010) 3 48
  5. A disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) is a novel fibrillin-1-, fibrillin-2-, and heparin-binding member of the ADAMTS superfamily containing a netrin-like module. (PMID: 23010571) Bader H.L. … Apte S.S. (Matrix Biol. 2012) 3 4

Products for ADAMTSL5 Gene

Sources for ADAMTSL5 Gene

Back to Top