Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTSL5 Gene

protein-coding   GIFtS: 46
GCID: GC19M001510

ADAMTS-like 5

(Previous names: thrombospondin, type I, domain containing 6 )
(Previous symbol: THSD6)
  Search for ADAMTSL5
in our new
 Human Malady Compendium 
Biological research products
for ADAMTSL5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
ADAMTS-Like 51 2
THSD61 2 3
Thrombospondin, Type I, Domain Containing 61 2
Thrombospondin Type-1 Domain-Containing Protein 62 3
ADAMTSL-52 3
ADAMTS-Like Protein 52

External Ids:    HGNC: 279121   Entrez Gene: 3393662   Ensembl: ENSG000001857617   UniProtKB: Q6ZMM23   

Export aliases for ADAMTSL5 gene to outside databases

Previous GC identifers: GC19M001460 GC19M001279


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTSL5 gene promoter:
         AhR   AML1a   Pax-5   Cdc5   AP-2gamma   C/EBPalpha   Arnt   ARP-1   Msx-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTSL5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTSL5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTSL5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ADAMTSL5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTSL5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M001510:  view genomic region     (about GC identifiers)

Start:
1,505,017 bp from pter      End:
1,513,603 bp from pter
Size:
8,587 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATL5_HUMAN, Q6ZMM2 (See protein sequence)
Recommended Name: ADAMTS-like protein 5 precursor  
Size: 471 amino acids; 52046 Da
Subcellular location: Secreted (Potential)
Caution: Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like
domains which are typical of that family
Secondary accessions: Q8IW95

Explore the universe of human proteins at neXtProt for ADAMTSL5: NX_Q6ZMM2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZMM2

  • ADAMTSL5 Protein expression data from MOPED and PaxDb:    About this image 
    ADAMTSL5 Protein Expression
    REFSEQ proteins: NP_998769.2  
    ENSEMBL proteins: 
     ENSP00000327608   ENSP00000466151   ENSP00000466231   ENSP00000465064   ENSP00000399364  
     ENSP00000378850  

    Human Recombinant Protein Products for ADAMTSL5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ADAMTSL5
    OriGene Protein Over-expression Lysate: ADAMTSL5
    OriGene Custom Protein Services for ADAMTSL5 
    GenScript Custom Purified and Recombinant Proteins Services for ADAMTSL5
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ADAMTSL5

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    ADAMTSL5 for ontologies           About GeneDecksing



    ADAMTSL5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies: ADAMTSL5
    OriGene Custom Antibody Services for ADAMTSL5 
    GenScript Custom Superior Antibodies Services for ADAMTSL5
    Novus Biologicals ADAMTSL5 Antibody
    Abcam antibodies for ADAMTSL5 
    Uscn Antibodies for ADAMTSL5
    ThermoFisher Antibodies for ADAMTSL5

    Assay Products for ADAMTSL5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ADAMTSL5
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ADAMTSL5


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ADAMTSL5 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000884 Thrombospondin_1_rpt
     IPR008993 TIMP-like_OB-fold
     IPR010294 ADAM_spacer1
     IPR001134 Netrin_domain
     IPR013273 Peptidase_M12B_ADAM-TS

    Graphical View of Domain Structure for InterPro Entry Q6ZMM2

    ProtoNet protein and cluster: Q6ZMM2

    UniProtKB/Swiss-Prot: ATL5_HUMAN, Q6ZMM2
    Similarity: Contains 1 NTR domain
    Similarity: Contains 1 TSP type-1 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ADAMTSL5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAMTSL5:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAMTSL5 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: ADAMTSL5
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTSL5
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTSL5:
    hsa-miR-221* hsa-miR-593 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidADAMTSL5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTSL5 (see all 7)
    OriGene shRNA RFP: ADAMTSL5
    OriGene siRNA: ADAMTSL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTSL5
    Sirion Biotech Custom design and validation of potent shRNA sequences against ADAMTSL5 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ADAMTSL5
    Sirion Biotech Customized adenovirus for overexpression of ADAMTSL5 
    Sirion Biotech Customized adenovirus for potent knockdown of ADAMTSL5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTSL5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTSL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAMTSL5 (NM_213604)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTSL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTSL5 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ADAMTSL5
    Search LifeMap BioReagents cell lines for ADAMTSL5
    Sirion Biotech Customized stable knockdown cell line services for ADAMTSL5 
    Sirion Biotech Customized inducible knockdown cell line services for ADAMTSL5
    Sirion Biotech Customized stable overexpressing cell line services for ADAMTSL5
    Sirion Biotech Customized inducible overexpressing cell line services for ADAMTSL5

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTSL5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTSL5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ADAMTSL5 (ENSP000003276084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ADAMTSL5
    Search CenterWatch for drugs/clinical trials and news about ADAMTSL5 / ATL5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ADAMTSL5 gene: 
    NM_213604.2  

    Unigene Cluster for ADAMTSL5:

    ADAMTS-like 5
    Hs.371674  [show with all ESTs]
    Unigene Representative Sequence: NM_213604
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000330475(uc010dsl.2 uc002ltd.2 uc010xgq.1) ENST00000591077
    ENST00000585700 ENST00000590440 ENST00000590562 ENST00000590682 ENST00000590090
    ENST00000587828 ENST00000586272 ENST00000589839 ENST00000585804 ENST00000413997
    ENST00000395467

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: ADAMTSL5
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ADAMTSL5
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ADAMTSL5:
    hsa-miR-221* hsa-miR-593 hsa-miR-758
    SwitchGear 3'UTR luciferase reporter plasmidADAMTSL5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTSL5 (see all 7)
    OriGene shRNA RFP: ADAMTSL5
    OriGene siRNA: ADAMTSL5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTSL5
    Sirion Biotech Custom design and validation of potent shRNA sequences against ADAMTSL5 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTSL5 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTSL5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ADAMTSL5 (NM_213604)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ADAMTSL5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTSL5 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTSL5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTSL5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTSL5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTSL5

    Additional cDNA sequence: 

    AK131571.1 AK302020.1 BC040620.1 BC119796.1 BC139833.1 

    5 DOTS entries:

    DT.97788062  DT.91639539  DT.100728369  DT.95297433  DT.100679094 

    24/33 AceView cDNA sequences (see all 33):

    AI452941 BM547593 N42597 AI027207 AW517025 AI347345 BX114196 AW294332 
    AK131571 BC040620 N46028 AI197889 NM_213604 N31586 BX951496 BV191083 
    BX115742 N36811 BX390004 CD359004 N68535 AI866924 BX384083 AW167554 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTSL5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
    SP1:              -                                   -                                             
    SP2:                    -                             -                                             
    SP3:        -           -                                                                           
    SP4:                                                                                                


    ECgene alternative splicing isoforms for ADAMTSL5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTSL5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCTGCTCCT
    ADAMTSL5 Expression
    About this image

    ADAMTSL5 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungTracheaBasal CellsLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)

    See ADAMTSL5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTSL5

    SOURCE GeneReport for Unigene cluster: Hs.371674
        SABiosciences Custom PCR Arrays for ADAMTSL5
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTSL5
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ADAMTSL5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTSL5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTSL5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTSL5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTSL5 gene from 3/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC4272641 ADAMTS-like protein 5-like 63.92(n)
    54.79(a)
      427264  XM_003642878.1  XP_003642926.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CR382298.36
    CABZ01090712.16
    --
    33(a)
    2(a)
    1 ↔ 1
    possible ortholog
    7(51934357-51973041)
    18(286342-288193)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG98506
    --
    3(a)
    1 ↔ 1
    2R(19641237-19685915)


    ENSEMBL Gene Tree for ADAMTSL5 (if available)
    TreeFam Gene Tree for ADAMTSL5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTSL5 gene
    ADAMTSL42  ADAMTS132  ADAMTSL12  ENSG000002156162  THSD42  ADAMTSL22  ADAMTSL32  PAPLN2  
    5 SIMAP similar genes for ADAMTSL5 using alignment to 7 protein entries:     ATL5_HUMAN (see all proteins):
    PAPLN    ADAMTS16    ADAMTS6    ADAMTS18    ADAMTSL1

    ADAMTSL5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/227 NCBI SNPs in ADAMTSL5 are shown (see all 227    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs791499121,2
    F--1504542(+) GGCTGG/TACCAG 1 -- int11Minor allele frequency- T:0.08NA 120
    rs1492012741,2
    --1504585(+) CCTACC/GCATGA 1 -- int10--------
    rs593620731,2
    C--1504595(+) AGCAAG/AGTCGA 1 -- int12Minor allele frequency- A:0.18CSA WA 120
    rs2653011,2
    C,F,H--1504618(+) CCAGCG/ATGTCC 1 -- int126Minor allele frequency- A:0.45NS EA NA WA CSA 2623
    rs1142197181,2
    C--1504858(+) ACACCA/GGGTCC 1 -- int10--------
    rs1902559721,2
    --1504868(+) CTTTGC/TGGGGT 1 -- int10--------
    rs1394014721,2
    --1504894(+) GGAGAA/GCATTA 1 -- int10--------
    rs1433083281,2
    --1504979(+) GTGTAA/TACTAA 1 -- int10--------
    rs795267361,2
    C--1505100(+) GATAGT/CGCATG 1 -- ut312Minor allele frequency- C:0.09WA 120
    rs1475258681,2
    --1505137(+) CGAGGC/GAGGAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ADAMTSL5 (1505017 - 1513603 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for ADAMTSL5
         4 CNVs: 7191 4066 30059 5066

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTSL5
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTSL5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ADAMTSL5 for disorders           About MalaCards

    ADAMTSL5 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: ADAMTSL5 (2 documents)

    Export disorders for ADAMTSL5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTSL5 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADAMTSL5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
    4. Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
    5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    6. Pan-genome isolation of low abundance transcripts using SAGE tag. (PubMed id 17113583)1 Kim Y.C....Wang S.M. (2006)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339366 HGNC: 27912 AceView: THSD6 Ensembl:ENSG00000185761 euGenes: HUgn339366
    ECgene: ADAMTSL5 H-InvDB: ADAMTSL5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTSL5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ADAMTSL5 gene:
    Search GeneIP for patents involving ADAMTSL5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for ADAMTSL5   OriGene shRNA RFP for ADAMTSL5  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ADAMTSL5   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ADAMTSL5  
     OriGene Protein Over-expression Lysate for ADAMTSL5   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ADAMTSL5   OriGene 3'-UTR Clone for ADAMTSL5  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTSL5   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ADAMTSL5  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ADAMTSL5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ADAMTSL5   OriGene Custom Protein Services for ADAMTSL5  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ADAMTSL5
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ADAMTSL5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTSL5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ADAMTSL5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ADAMTSL5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ADAMTSL5
     GenScript Custom Purified and Recombinant Proteins Services for ADAMTSL5 GenScript cDNA clones with any tag delivered in your preferred vector for ADAMTSL5
     GenScript Custom Assay Services for ADAMTSL5 GenScript Custom Superior Antibodies Services for ADAMTSL5
     GenScript Custom overexpressing Cell Line Services for ADAMTSL5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ADAMTSL5 promoter
     Search Chromatin IP Primers for ADAMTSL5
     RT2 qPCR Primer Assay in human, mouse, rat ADAMTSL5
     Search GNC Networks for ADAMTSL5
     SABiosciences Custom PCR Arrays for ADAMTSL5
     Search Tocris compounds for ADAMTSL5
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ADAMTSL5 antibodies
     Antibodies for ADAMTSL5
     See all of Abcam's Antibodies, Kits and Proteins for ADAMTSL5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ADAMTSL5 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ADAMTSL5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTSL5
     SwitchGear 3'UTR luciferase reporter plasmids for ADAMTSL5
     SwitchGear Promoter luciferase reporter plasmids for ADAMTSL5
     ThermoFisher Antibodies for ADAMTSL5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTSL5
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ADAMTSL5
    Sirion Biotech Customized:
     stable knockdown cell line services for ADAMTSL5
     inducible knockdown cell line services for ADAMTSL5
     design and validation of potent shRNA sequences against ADAMTSL5
     adenovirus for potent knockdown of ADAMTSL5
     adenovirus for overexpression of ADAMTSL5
     stable overexpressing cell line services for ADAMTSL5
     inducible overexpressing cell line services for ADAMTSL5
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ADAMTSL5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4