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ADAMTSL3 Gene

protein-coding   GIFtS: 52
GCID: GC15P084322

ADAMTS-Like 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAMTS-Like 31 2     ADAMTS-Like Protein 32
ADAMTSL-32 3     punctin-22
KIAA12333 5     Punctin-23
A Disintegrin-Like And Metalloprotease Domain With Thrombospondin Type I
Motifs-Like 32
     

External Ids:    HGNC: 146331   Entrez Gene: 571882   Ensembl: ENSG000001562187   OMIM: 6091995   UniProtKB: P829873   

Export aliases for ADAMTSL3 gene to outside databases

Previous GC identifers: GC15P082043 GC15P082113 GC15P060587


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ADAMTSL3 Gene:
ADAMTSL3 (ADAMTS-like 3) is a protein-coding gene. Diseases associated with ADAMTSL3 include familial colorectal cancer, and colorectal cancer. GO annotations related to this gene include metallopeptidase activity. An important paralog of this gene is ADAMTSL4.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTSL3 gene promoter:
         HFH-3   GR   AhR   Sp1   Nkx2-5   LCR-F1   Egr-4   C/EBPalpha   FOXI1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTSL3 promoter sequence
   Search Chromatin IP Primers for ADAMTSL3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTSL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q25.2   Ensembl cytogenetic band:  15q25.2   HGNC cytogenetic band: 15q25.2

ADAMTSL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTSL3 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P084322:  view genomic region     (about GC identifiers)

Start:
84,322,838 bp from pter      End:
84,708,594 bp from pter
Size:
385,757 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ATL3_HUMAN, P82987 (See protein sequence)
Recommended Name: ADAMTS-like protein 3 precursor  
Size: 1691 amino acids; 188692 Da
Caution: Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and
disintegrin-like domains which are typical of that family
Secondary accessions: A1A566 A1A567 Q9ULI7
Alternative splicing: 2 isoforms:  P82987-1   P82987-2   

Explore the universe of human proteins at neXtProt for ADAMTSL3: NX_P82987

Explore proteomics data for ADAMTSL3 at MOPED

Post-translational modifications: 

  • Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the
    consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second
    cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the
    addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient
    secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan
    residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can
    also facilitate secretion (By similarity)1
  • Glycosylation2 at Asn293, Asn681, Asn797, Asn915, Asn927, Asn1102, Asn1191, Asn1292, Asn1316, Asn1330,
                                 Asn1343, Asn1349, Asn1356, Asn1432, Asn1516, Asn1574, Asn1591
  • Modification sites at PhosphoSitePlus

  • See ADAMTSL3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_997400.2  
    ENSEMBL proteins: 
     ENSP00000286744   ENSP00000456313  
    Reactome Protein details: P82987

    ADAMTSL3 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ADAMTSL3

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    Cloud-Clone Corp. CLIAs for ADAMTSL3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 8):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR010909 PLAC
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P82987

    ProtoNet protein and cluster: P82987

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: ATL3_HUMAN, P82987
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 10 TSP type-1 domains


    ADAMTSL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    ADAMTSL3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAMTSL3:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ADAMTSL3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ADAMTSL3
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    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAMTSL3 (see all 57):
    hsa-miR-520f hsa-miR-642a hsa-miR-193a-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-15a hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidADAMTSL3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ADAMTSL3
    Predesigned siRNA for gene silencing in human, mouse, rat ADAMTSL3

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: ADAMTSL3 (NM_207517)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTSL3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATL3_HUMAN, P82987: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane3
    cytosol1
    golgi apparatus1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--

    ADAMTSL3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for ADAMTSL3
        O-glycosylation of TSR domain-containing proteins



    ADAMTSL3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTSL3
    Interactions:

        Search GeneGlobe Interaction Network for ADAMTSL3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAMTSL3 (ATL3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ADAMTSL3 gene: 
    NM_207517.2  

    Unigene Cluster for ADAMTSL3:

    ADAMTS-like 3
    Hs.459162  [show with all ESTs]
    Unigene Representative Sequence: NM_207517
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000286744(uc002bjz.4) ENST00000567476 ENST00000569510(uc002bjy.1)
    ENST00000561483(uc010bmt.1) ENST00000565653 ENST00000567663 ENST00000562296
    ENST00000567716
    miRNA
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    Block miRNA regulation of human, mouse, rat ADAMTSL3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ADAMTSL3 (see all 57):
    hsa-miR-520f hsa-miR-642a hsa-miR-193a-3p hsa-miR-300 hsa-miR-513a-5p hsa-miR-199a-3p hsa-miR-15a hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidADAMTSL3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ADAMTSL3
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    GenScript: all cDNA clones in your preferred vector: ADAMTSL3 (NM_207517)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ADAMTSL3
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ADAMTSL3
      QuantiTect SYBR Green Assays in human, mouse, rat ADAMTSL3
      QuantiFast Probe-based Assays in human, mouse, rat ADAMTSL3

    Additional mRNA sequence: 

    AB033059.1 AF237652.1 AK092324.1 AK308845.1 AL109723.1 AL109724.1 BC128389.1 BC128390.1 

    4 DOTS entries:

    DT.410933  DT.121015571  DT.100017164  DT.121015569 

    Selected AceView cDNA sequences (see all 44):

    CD673150 AI611758 AA029682 AI174440 CR621245 AB033059 BX481817 NM_207517 
    AA723257 AL109724 AA707140 CD515059 AK092324 W90396 AL109723 AX747482 
    N98222 BX419270 BG750735 AA330156 BX506348 W88505 AF237652 BX455128 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTSL3 expression in normal human tissues (normalized intensities)      ADAMTSL3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ADAMTSL3 Expression
    About this image


    ADAMTSL3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Ovary (Reproductive System)
    ADAMTSL3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTSL3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.459162

    UniProtKB/Swiss-Prot: ATL3_HUMAN, P82987
    Tissue specificity: Expressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate,
    epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle
    cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial
    cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in
    colon cancer compared to normal colon

        Custom PCR Arrays for ADAMTSL3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ADAMTSL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTSL3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamtsl31 , 5 ADAMTS-like 31, 5 83.93(n)1
    85.44(a)1
      7 (47.18 cM)5
    2699591  NM_001190374.11  NP_001177303.11 
     823356945 
    chicken
    (Gallus gallus)
    Aves ADAMTSL31 ADAMTS-like 3 68(n)
    66.14(a)
      415465  XM_004943824.1  XP_004943881.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTSL36
    ADAMTS-like 3
    59(a)
    1 ↔ 1
    GL343740.1(65557-185596)
    zebrafish
    (Danio rerio)
    Actinopterygii adamtsl31 ADAMTS-like 3 56.64(n)
    52.05(a)
      100534944  XM_003198899.2  XP_003198947.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316196
    --
    27(a)
    1 → many
    2L(21684103-21729051)
    worm
    (Caenorhabditis elegans)
    Secernentea T19D2.16
    Protein T19D2.1 (T19D2.1) mRNA, complete cds
    11(a)
    many ↔ many
    X(3931770-3937881) WBGene00020567


    ENSEMBL Gene Tree for ADAMTSL3 (if available)
    TreeFam Gene Tree for ADAMTSL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTSL3 gene
    ADAMTSL42  ADAMTS72  ADAMTS132  ADAMTS122  THSD42  ADAMTSL22  PAPLN2  ADAMTSL52  
    ADAMTSL12  ENSG000002156162  
    1 SIMAP similar gene for ADAMTSL3 using alignment to 1 protein entry:     ATL3_HUMAN:
    ADAMTSL1

    ADAMTSL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTSL3 (see all 7259)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358104
    A colorectal cancer sample4--see VAR_0358102 R H mis40--------
    VAR_0358114
    A colorectal cancer sample4--see VAR_0358112 R C mis40--------
    VAR_0358094
    A colorectal cancer sample4--see VAR_0358092 V M mis40--------
    VAR_0358124
    A colorectal cancer sample4--see VAR_0358122 A E mis40--------
    rs114491891,2
    C,H--60902746(+) aaaaaA/Gaaaga 1 -- int1 trp31Minor allele frequency- G:0.00NA 2
    rs595227211,2
    C--64199198(+) CCATG-/AAATTCA 1 -- int10--------
    rs1129916311,2
    C,F--84320839(+) TAAGGC/TCCAAC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs11170971,2
    C,F,H--84321048(+) AATACG/ATAAGT 1 -- us2k19Minor allele frequency- A:0.01NS EA NA WA 928
    rs1482899281,2
    C--84321195(+) CAAAAA/GTATTG 1 -- us2k10--------
    rs27300781,2
    C,F,A,H--84321429(+) GTCCAA/GTCATT 1 -- us2k124Minor allele frequency- G:0.13NS EA NA CSA 2544

    HapMap Linkage Disequilibrium report for ADAMTSL3 (84322838 - 84572838 bp, first 250kb of ADAMTSL3)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAMTSL3 (see all 27):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670578CNV Deletion23128226
    esv2659307CNV Deletion23128226
    esv1949100CNV Deletion18987734
    esv2421820CNV Deletion20811451
    esv2664036CNV Deletion23128226
    esv2421901CNV Deletion20811451
    esv2749964CNV Deletion23290073
    esv2675330CNV Deletion23128226
    esv2474245CNV Deletion19546169
    nsv513435CNV Insertion21212237

    Human Gene Mutation Database (HGMD): ADAMTSL3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ADAMTSL3
    DNA2.0 Custom Variant and Variant Library Synthesis for ADAMTSL3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609199    OMIM disorders: --

    9 diseases for ADAMTSL3:    About MalaCards
    familial colorectal cancer    colorectal cancer    breast and colorectal cancer    schizophrenia
    pancreatitis    endotheliitis    prostatitis    malaria
    neuronitis


    ADAMTSL3 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ADAMTSL3
    Human Genome Epidemiology (HuGE) Navigator: ADAMTSL3 (8 documents)

    Export disorders for ADAMTSL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTSL3 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ADAMTSL3)
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    1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1999)
    2. ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer. (PubMed id 17597111)1, 2, 9 Koo B.H.... Apte S.S. (Int. J. Cancer 2007)
    3. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. (PubMed id 14667842)1, 2, 9 Hall N.G.... Apte S.S. (Matrix Biol. 2003)
    4. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (PLoS Genet. 2011)
    5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    6. A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci. (PubMed id 20189936)1, 4 Okada Y....Kamatani N. (Hum. Mol. Genet. 2010)
    7. Genome-wide association study of height and body mass index in Australian twin families. (PubMed id 20397748)1, 4 Liu J.Z....McRae A.F. (Twin Res Hum Genet 2010)
    8. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1, 4 Sovio U....Jarvelin M.R. (PLoS Genet. 2009)
    9. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. (PubMed id 19343178)1, 4 Soranzo N....Deloukas P. (PLoS Genet. 2009)
    10. Genome-wide association analysis identifies 20 loci that influence adult height. (PubMed id 18391952)1, 4 Weedon M.N....Frayling T.M. (Nat. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57188 HGNC: 14633 AceView: ADAMTSL3 Ensembl:ENSG00000156218 euGenes: HUgn57188
    ECgene: ADAMTSL3 H-InvDB: ADAMTSL3

    (According to HUGE)
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    HUGE: KIAA1233

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMTSL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMTSL3 gene:
    Search GeneIP for patents involving ADAMTSL3

    GeneCards and IP:
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