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Aliases for ADAMTSL3 Gene

Aliases for ADAMTSL3 Gene

  • ADAMTS Like 3 2 3 5
  • Punctin-2 3 4
  • ADAMTSL-3 3 4
  • A Disintegrin-Like And Metalloprotease Domain With Thrombospondin Type I Motifs-Like 3 3
  • ADAMTS-Like 3 3
  • KIAA1233 4

External Ids for ADAMTSL3 Gene

Previous GeneCards Identifiers for ADAMTSL3 Gene

  • GC15P082043
  • GC15P082113
  • GC15P084322
  • GC15P060587

Summaries for ADAMTSL3 Gene

GeneCards Summary for ADAMTSL3 Gene

ADAMTSL3 (ADAMTS Like 3) is a Protein Coding gene. Among its related pathways are O-glycosylation of TSR domain-containing proteins and Infectious disease. GO annotations related to this gene include peptidase activity and metallopeptidase activity. An important paralog of this gene is ADAMTSL1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ADAMTSL3 Gene

Genomics for ADAMTSL3 Gene

Regulatory Elements for ADAMTSL3 Gene

Enhancers for ADAMTSL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ADAMTSL3 on UCSC Golden Path with GeneCards custom track

Promoters for ADAMTSL3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ADAMTSL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for ADAMTSL3 Gene

Chromosome:
15
Start:
83,654,086 bp from pter
End:
84,039,842 bp from pter
Size:
385,757 bases
Orientation:
Plus strand

Genomic View for ADAMTSL3 Gene

Genes around ADAMTSL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ADAMTSL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ADAMTSL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ADAMTSL3 Gene

Proteins for ADAMTSL3 Gene

  • Protein details for ADAMTSL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P82987-ATL3_HUMAN
    Recommended name:
    ADAMTS-like protein 3
    Protein Accession:
    P82987
    Secondary Accessions:
    • A1A566
    • A1A567
    • Q9ULI7

    Protein attributes for ADAMTSL3 Gene

    Size:
    1691 amino acids
    Molecular mass:
    188692 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ADAMTSL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ADAMTSL3 Gene

Proteomics data for ADAMTSL3 Gene at MOPED

Post-translational modifications for ADAMTSL3 Gene

  • Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
  • Glycosylation at Asn 293, Asn 681, Asn 797, Asn 915, Asn 927, Asn 1102, Asn 1191, Asn 1292, Asn 1316, Asn 1330, Asn 1343, Asn 1349, Asn 1356, Asn 1432, Asn 1516, Asn 1574, and Asn 1591
  • Modification sites at PhosphoSitePlus

Other Protein References for ADAMTSL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ADAMTSL3 Gene

Domains & Families for ADAMTSL3 Gene

Suggested Antigen Peptide Sequences for ADAMTSL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P82987

UniProtKB/Swiss-Prot:

ATL3_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 PLAC domain.
  • Contains 10 TSP type-1 domains.
genes like me logo Genes that share domains with ADAMTSL3: view

Function for ADAMTSL3 Gene

Gene Ontology (GO) - Molecular Function for ADAMTSL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
GO:0008237 metallopeptidase activity IEA --
genes like me logo Genes that share ontologies with ADAMTSL3: view
genes like me logo Genes that share phenotypes with ADAMTSL3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ADAMTSL3

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ADAMTSL3 Gene

Localization for ADAMTSL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ADAMTSL3 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ADAMTSL3 Gene COMPARTMENTS Subcellular localization image for ADAMTSL3 gene
Compartment Confidence
extracellular 4
plasma membrane 3
cytosol 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ADAMTSL3 Gene

Pathways & Interactions for ADAMTSL3 Gene

genes like me logo Genes that share pathways with ADAMTSL3: view

Gene Ontology (GO) - Biological Process for ADAMTSL3 Gene

None

No data available for SIGNOR curated interactions for ADAMTSL3 Gene

Drugs & Compounds for ADAMTSL3 Gene

No Compound Related Data Available

Transcripts for ADAMTSL3 Gene

Unigene Clusters for ADAMTSL3 Gene

ADAMTS-like 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTSL3 Gene

No ASD Table

Relevant External Links for ADAMTSL3 Gene

GeneLoc Exon Structure for
ADAMTSL3
ECgene alternative splicing isoforms for
ADAMTSL3

Expression for ADAMTSL3 Gene

mRNA expression in normal human tissues for ADAMTSL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ADAMTSL3 Gene

This gene is overexpressed in Artery - Aorta (x6.3) and Artery - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for ADAMTSL3 Gene

This gene is overexpressed in Adipocyte (36.6), Colon (18.7), and Spinal cord (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ADAMTSL3 Gene



SOURCE GeneReport for Unigene cluster for ADAMTSL3 Gene Hs.459162

mRNA Expression by UniProt/SwissProt for ADAMTSL3 Gene

P82987-ATL3_HUMAN
Tissue specificity: Expressed in epithelial cells of the colon, fallopian tube, skin, breast, prostate, epididymis, liver, pancreatic islets and bile ducts, as well as by vascular endothelial cells, smooth muscle cells, fibroblasts, cortical and ganglionic neurons and cardiac myocytes. Also expressed by malignant epithelial cells in colon cancer, as well as breast, prostate, renal and skin tumors. Expression is significantly reduced in colon cancer compared to normal colon.
genes like me logo Genes that share expression patterns with ADAMTSL3: view

Protein tissue co-expression partners for ADAMTSL3 Gene

Primer Products

Orthologs for ADAMTSL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for ADAMTSL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ADAMTSL3 35
  • 88.95 (n)
  • 92.45 (a)
ADAMTSL3 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ADAMTSL3 35
  • 87.41 (n)
  • 87.71 (a)
ADAMTSL3 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Adamtsl3 35
  • 83.93 (n)
  • 85.44 (a)
Adamtsl3 16
Adamtsl3 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ADAMTSL3 35
  • 99.21 (n)
  • 98.76 (a)
ADAMTSL3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Adamtsl3 35
  • 84.37 (n)
  • 85.36 (a)
oppossum
(Monodelphis domestica)
Mammalia ADAMTSL3 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
chicken
(Gallus gallus)
Aves ADAMTSL3 35
  • 68 (n)
  • 66.14 (a)
ADAMTSL3 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ADAMTSL3 36
  • 59 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii adamtsl3 35
  • 56.64 (n)
  • 52.05 (a)
ADAMTSL3 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG31619 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T19D2.1 36
  • 11 (a)
ManyToMany
Species with no ortholog for ADAMTSL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ADAMTSL3 Gene

ENSEMBL:
Gene Tree for ADAMTSL3 (if available)
TreeFam:
Gene Tree for ADAMTSL3 (if available)

Paralogs for ADAMTSL3 Gene

Paralogs for ADAMTSL3 Gene

(1) SIMAP similar genes for ADAMTSL3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ADAMTSL3: view

Variants for ADAMTSL3 Gene

Sequence variations from dbSNP and Humsavar for ADAMTSL3 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs4483821 - 83,819,884(+) GGGGC(A/G)TTACT nc-transcript-variant, reference, missense
rs4144691 - 83,870,867(-) TACGA(C/G)AAAGA nc-transcript-variant, reference, missense
rs4842838 - 83,913,372(+) CATGC(A/G/T)TGGGA nc-transcript-variant, reference, missense
rs2277848 - 83,970,557(+) TCGGC(A/C/G)CATCC downstream-variant-500B, reference, missense
rs2277849 - 83,970,598(+) CAGGG(C/T)TCCCT downstream-variant-500B, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ADAMTSL3 Gene

Variant ID Type Subtype PubMed ID
nsv833072 CNV Gain 17160897
nsv524815 CNV Loss 19592680
nsv833073 CNV Loss 17160897
nsv513435 CNV Insertion 21212237
esv2623099 CNV Insertion 19546169
esv1949100 CNV Deletion 18987734
nsv904451 CNV Loss 21882294
dgv765e1 CNV Complex 17122850
esv2421901 CNV Deletion 20811451
nsv442707 CNV CNV 18776908
esv25908 CNV Loss 19812545
nsv9289 CNV Loss 18304495
dgv444n67 CNV Loss 20364138
esv2749964 CNV Deletion 23290073
nsv514787 CNV Loss 21397061
esv2670578 CNV Deletion 23128226
nsv498854 CNV Loss 21111241
esv2421820 CNV Deletion 20811451
nsv833074 CNV Gain 17160897
esv2664036 CNV Deletion 23128226
esv2474245 CNV Deletion 19546169
esv2675330 CNV Deletion 23128226
esv21721 CNV Loss 19812545
nsv833075 CNV Gain 17160897
dgv2429n71 CNV Loss 21882294
esv2659307 CNV Deletion 23128226
nsv457220 CNV Gain 19166990

Variation tolerance for ADAMTSL3 Gene

Residual Variation Intolerance Score: 76.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.50; 96.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ADAMTSL3 Gene

HapMap Linkage Disequilibrium report
ADAMTSL3
Human Gene Mutation Database (HGMD)
ADAMTSL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ADAMTSL3 Gene

Disorders for ADAMTSL3 Gene

Relevant External Links for ADAMTSL3

Genetic Association Database (GAD)
ADAMTSL3
Human Genome Epidemiology (HuGE) Navigator
ADAMTSL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ADAMTSL3

No disorders were found for ADAMTSL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ADAMTSL3 Gene

Publications for ADAMTSL3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10574462) Nagase T. … Ohara O. (DNA Res. 1999) 2 3 4 67
  2. ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer. (PMID: 17597111) Koo B.H. … Apte S.S. (Int. J. Cancer 2007) 3 23
  3. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. (PMID: 14667842) Hall N.G. … Apte S.S. (Matrix Biol. 2003) 3 23
  4. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9628581) Nagase T. … Ohara O. (DNA Res. 1998) 2 3
  5. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3

Products for ADAMTSL3 Gene

Sources for ADAMTSL3 Gene

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