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Aliases &
Descriptions
for ADAMTSL3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| ADAMTSL-3 3 | | KIAA1233 1, 2, 3 | | MGC150716 2 | | MGC150717 2 | | Punctin-2 3 | | punctin-2 1, 2 |
| | | Descriptions |
|---|
| ADAMTS-like 3 2 | a disintegrin-like and metalloprotease domain with
thrombospondin type I motifs-like 3 2 |
|
| |
Search outside databases for aliases for ADAMTSL3 genePrevious GC identifer: GC15P082043 |
Summaries
for ADAMTSL3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Location
for ADAMTSL3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the ADAMTSL3 gene 
Entrez Gene cytogenetic band: 15q25.2 Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q25.2ADAMTSL3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P082113:
(about GC identifiers)
Start:
|
82,113,842 bp from pter |
End:
|
82,499,598 bp from pter |
Size:
|
385,757 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000015.8 NT_077661.2
| Proteins
for ADAMTSL3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: ATL3_HUMAN, P82987 (See
protein sequence)Recommended Name: ADAMTS-like protein 3 precursor Size: 1691 amino acids; 188644 Da
Subcellular location: Secreted, extracellular space, extracellular matrix
Caution: Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and
disintegrin-like domains which are typical of that family
Secondary accessions: Q9ULI7Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_997400.2
ENSEMBL proteins: ENSP00000286745 ENSP00000286744
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005578 | proteinaceous extracellular matrix |
IEA | -- |
About this table
Antibodies for ADAMTSL3:
Assays for ADAMTSL3: | Protein
Domains/
Families
for ADAMTSL3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P82987
ProtoNet protein and cluster: P82987 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: ATL3_HUMAN, P82987Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 PLAC domainSimilarity: Contains 10 TSP type-1 domains | Gene Function
for ADAMTSL3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_207517
 Applied Biosystems Silencer® siRNAs for ADAMTSL3
 Sigma-Aldrich siRNA and siRNA Panels for ADAMTSL3
Sigma-Aldrich shRNA Panels and shRNA for ADAMTSL3
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_207517
Myc/DDK tagged cDNA clone in CMV expression vector: NM_207517
untagged cDNA clones in CMV expression vector (see all 2): AB033059
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_207517
3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008233 | peptidase activity |
IEA | -- | | GO:0008237 | metallopeptidase activity |
IEA | -- | | GO:0008270 | zinc ion binding |
IEA | -- |
About this table | Pathways & Interactions
for ADAMTSL3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
-- |
Drugs & Compounds
for ADAMTSL3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for ADAMTSL3
|
Transcripts
for ADAMTSL3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_207517
Sigma-Aldrich siRNA and siRNA Panels for ADAMTSL3
Sigma-Aldrich shRNA Panels and shRNA for ADAMTSL3
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_207517 REFSEQ mRNAs for ADAMTSL3 gene: NM_207517.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_207517
OriGene GFP tagged cDNA clone in CMV expression vector: NM_207517
Myc/DDK tagged cDNA clone in CMV expression vector: NM_207517
untagged cDNA clones in CMV expression vector (see all 2): AB033059
Additional cDNA sequence: AB033059.1 AF237652.1 AK092324.1 AK308845.1 AL109723.1 AL109724.1 BC128389.1 BC128390.1 CR621245.1 4 DOTS entries: DT.410933 DT.121015571 DT.100017164 DT.121015569 24/44 AceView cDNA sequences (see all 44
):AB033059 CD673150 AI611758 AA723257 AI174440 BX481817 AA029682 NM_207517 AL109724 CR621245 D63119 AA707140 AW029535 AA330156 H26489 AK092324 N98222 N70193 W90396 AI394217 BX455128 BX419270 W88505 BG750735
 highest scoring ESTs for ADAMTSL3:AA029682 AA330156 AA723257 AB033059 AI174440 AI394217 AI435876 AI611758 AL109724 AV682378 Unigene Cluster for ADAMTSL3: ADAMTS-like 3 Hs.459162 [show with all ESTs]Unigene Representative Sequence: NM_207517
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000286745
ENST00000286744
|
Expression
for ADAMTSL3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| ADAMTSL3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for ADAMTSL3
1 / 2 / 3 4 probe-sets matching ADAMTSL3 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.459162
Expression variation in blood from EXPOLDB for ADAMTSL3 UniProtKB/Swiss-Prot: ATL3_HUMAN, P82987Tissue specificity: Widely expressed, with highest in liver, kidney, heart and skeletal muscle |
Orthologs
for ADAMTSL3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for ADAMTSL3 gene from 5/9 species (see all 9
)
About this table Species with no ortholog for ADAMTSL3
ENSEMBL Gene Tree for ADAMTSL3 | Paralogs
for ADAMTSL3(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
SNPs/Variants
for ADAMTSL3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for ADAMTSL3 (up to first 250kb)
|
Disorders & Mutations
for ADAMTSL3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609199
Human Genome Epidemiology Navigator: ADAMTSL3 (2 documents)
|
Medical News
for ADAMTSL3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for ADAMTSL3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/12 PubMed articles for ADAMTSL3 gene (see all 12
):- Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10574462)2, 3, 4 Nagase T....Ohara O. (1999)
- ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. (PubMed id 14667842)1, 3, 4 Hall N.G....Apte S.S. (2003)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)3, 4 Heilig R.... Weissenbach J. (2003)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)2, 3 Nagase T....Ohara O. (1998)
- ADAMTSL3/punctin-2, a gene frequently mutated in colorectal tumors, is widely expressed in normal and malignant epithelial cells, vascular endothelial cells and other cell types, and its mRNA is reduced in colon cancer. (PubMed id 17597111)1, 3 Koo B.H....Apte S.S. (2007)
- Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)3 Sovio U....Jarvelin M.R. (2009)
- Genome-wide association analysis identifies 20 loci that influence adult height. (PubMed id 18391952)3 Weedon M.N....Frayling T.M. (2008)
- Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)3 Gudbjartsson D.F....Stefansson K. (2008)
- Identification of ten loci associated with height highlights new biological pathways in human growth. (PubMed id 18391950)3 Lettre G....Hirschhorn J.N. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)4 Sjoeblom T.... Velculescu V.E. (2006)
|
Search for ADAMTSL3
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ADAMTSL3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing ADAMTSL3
(According to HUGE)
About This Section
| |
Specialized Databases showing ADAMTSL3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for ADAMTSL3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for ADAMTSL3:
|
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