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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ADAMTSL2 Gene

protein-coding   GIFtS: 53
GCID: GC09P136397

ADAMTS-like 2
 Explore 5 diseases affiliated with
ADAMTSL2 via
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Biological research products
for ADAMTSL2    

Aliases
for ADAMTSL2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADAMTS-Like 21 2
KIAA06051 3 5
ADAMTSL-22 3
GPHYSD12
ADAMTS-Like Protein 22

External Ids:    HGNC: 146311   Entrez Gene: 97192   Ensembl: ENSG000001978597   OMIM: 6122775   UniProtKB: Q86TH13   

Export aliases for ADAMTSL2 gene to outside databases

Previous GC identifers: GC09P133426 GC09P135387 GC09P105898


Summaries
for ADAMTSL2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ADAMTSL2:
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and
ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide
region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual
members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The
protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein
subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with
latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic
dysplasia. (provided by RefSeq, Feb 2009)




Genomic Views
for ADAMTSL2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_035014.4  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ADAMTSL2 gene promoter:
         S8   STAT1   FOXD3   STAT1beta   STAT1alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ADAMTSL2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ADAMTSL2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ADAMTSL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.2   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.3

ADAMTSL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTSL2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P136397:  view genomic region     (about GC identifiers)

Start:
 136,397,286 bp from pter      End:
 136,440,641 bp from pter
Size:
 43,356 bases      Orientation:
 plus strand

Proteins
for ADAMTSL2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ATL2_HUMAN, Q86TH1 (See protein sequence)
Recommended Name: ADAMTS-like protein 2 precursor  
Size: 951 amino acids; 104621 Da
Subunit: Interacts with LTBP1
Subcellular location: Secreted (Potential)
Miscellaneous: There is a significant increase in total and active TGFB1 in the culture medium as well as nuclear
localization of phosphorylated SMAD2 in fibroblasts from individuals with geleophysic dysplasia
Caution: Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like
domains which are typical of that family
Sequence caution: Sequence=BAA25531.2; Type=Erroneous initiation;
Secondary accessions: B1B0D5 O60345

Explore the universe of human proteins at neXtProt for ADAMTSL2: NX_Q86TH1

Post-translational modifications:

  • Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the
    • consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second
    cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of
    a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the
    consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion
    (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q86TH1

    • ADAMTSL2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001138792.1  NP_055509.2  

    ENSEMBL proteins: 
     ENSP00000346478   ENSP00000376781   ENSP00000376780  

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    Uscn Proteins for ADAMTSL2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--


    ADAMTSL2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ADAMTSL2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ADAMTSL2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000884 Thrombospondin_1_rpt
     IPR010294 ADAM_spacer1
     IPR010909 PLAC
     IPR013273 Peptidase_M12B_ADAM-TS

    Graphical View of Domain Structure for InterPro Entry Q86TH1

    ProtoNet protein and cluster: Q86TH1

    UniProtKB/Swiss-Prot: ATL2_HUMAN, Q86TH1
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 7 TSP type-1 domains


    Function
    for ADAMTSL2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-103a hsa-miR-93 hsa-miR-20b hsa-miR-526b*
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    Gene Editing
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity IEA--
    GO:0005515protein binding IPI18677313
    GO:0008233peptidase activity ----
    GO:0008270zinc ion binding IEA--


    ADAMTSL2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ADAMTSL2:
     Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for ADAMTSL2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ADAMTSL2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ADAMTSL2 (ENSP000003464784) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBLN1ENSP000003315444STRING: ENSP00000331544
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway IMP18677313


    ADAMTSL2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ADAMTSL2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ADAMTSL2
    Search CenterWatch for drugs/clinical trials and news about ADAMTSL2 / ATL2 

    Transcripts
    for ADAMTSL2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ADAMTSL2 gene (2 alternative transcripts): 
    NM_001145320.1  NM_014694.3  

    Unigene Cluster for ADAMTSL2:

    ADAMTS-like 2
    Hs.522543  [show with all ESTs]
    Unigene Representative Sequence: NM_001145320
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354484(uc011mdl.2 uc004cej.3) ENST00000393061(uc004cei.3)
    ENST00000393060

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    hsa-miR-20a hsa-miR-519d hsa-miR-106a hsa-miR-106b hsa-miR-103a hsa-miR-93 hsa-miR-20b hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmid: ADAMTSL2 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AB011177.1 AK127107.1 AK293498.1 BC050544.1 

    5 DOTS entries:

    DT.95096240  DT.302590  DT.99988147  DT.100747177  DT.121152030 

    24/56 AceView cDNA sequences (see all 56):

    BI966839 BU159537 BG820713 CK903629 BQ071334 BI963105 CK903628 CA952469 
    AI863311 BU151644 BI963035 BX098716 BX345176 AW444475 BU848668 BX509469 
    BE797153 BX359326 BC050544 BV185381 AK127107 CD625927 BU845571 BM923799 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTSL2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19
    SP1:              -                                                                                                                                       
    SP2:                                                                                                                                                      
    SP3:                                                                                                                                                      
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                                      


    ECgene alternative splicing isoforms for ADAMTSL2

    Expression
    for ADAMTSL2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ADAMTSL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGCTCTCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ADAMTSL2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    CartilageCervical Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageLumbar Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageSacral Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    CartilageThoracic Intervertebral DiscIntervertebral Disc Annulus Fibrosus CellsCartilage
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite
    Intervertebral disc (IVD) annulus fibrosus (AF) cells (Differentiation of s...)Cartilage

    See ADAMTSL2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ADAMTSL2

    SOURCE GeneReport for Unigene cluster: Hs.522543
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    In Situ
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    Orthologs
    for ADAMTSL2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTSL2 gene from 4/14 species (see all 14)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ADAMTSL21 ADAMTS-like 2 74.25(n)
    77.68(a)    		   417147  XM_003642304.1  XP_003642352.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 74(a)
    		 1 → many
    		 GL343999.1(39532-75229)
    zebrafish
    (Danio rerio)    		 Actinopterygii adamtsl21 ADAMTS-like 2 63.08(n)
    61.93(a)    		   100537087  XM_003198720.1  XP_003198768.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea mig-176
    		 ADAM family mig-17
    		 5(a)
    		 possible ortholog
    		 V(11446634-11449228)


    ENSEMBL Gene Tree for ADAMTSL2 (if available)
    TreeFam Gene Tree for ADAMTSL2 (if available) 

    Paralogs
    for ADAMTSL2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ADAMTSL2 gene
    ADAMTSL42  ADAMTS132  ADAMTSL12  ENSG000002156162  THSD42  ADAMTSL32  PAPLN2  ADAMTSL52  
    1 SIMAP similar gene for ADAMTSL2 using alignment to 2 protein entries:     ATL2_HUMAN (see all proteins):
    DKFZp434K1772

    ADAMTSL2 for paralogs           About GeneDecksing



    Genomic Variants
    for ADAMTSL2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/640 NCBI SNPs in ADAMTSL2 are shown (see all 640)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1139941221,2
    		Cpathogenic136404921(+) CTTCCA/GCGAGG 4 H R mis10--------
    rs1139941231,2
    		Cpathogenic136404923(+) TCCGCA/GAGGAG 4 K E mis10--------
    rs1139941211,2
    		Cpathogenic136405747(+) CAAACC/TGTGTG 4 P L mis10--------
    rs1139941241,2
    		Cpathogenic136435468(+) CCTGCA/GGGCGC 4 R G mis10--------
    rs1139941251,2
    		Cpathogenic136435623(+) CCCTGA/GTCAGA 4 * W stg10--------
    rs1883744631,2
    		--136395287(+) AAGGCC/TGCTCC 1 -- us2k10--------
    rs749397621,2
    		F,--136395313(+) CCCTGC/TGTCCC 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1399751261,2
    		--136395361(+) TCTACA/GTGGAA 1 -- us2k10--------
    rs1152859841,2
    		C,--136395387(+) GCACCA/GCATCC 1 -- us2k10--------
    rs1147558361,2
    		F,--136395482(+) GTCCCG/ACTGCT 1 -- us2k11Minor allele frequency- A:0.07WA 118

    HapMap Linkage Disequilibrium report for ADAMTSL2 (136397286 - 136440641 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 7 variations for ADAMTSL2
         2 CNVs: 3784 70809
         5 Indels: 47658 62955 41211 29069 42653
    Human Gene Mutation Database (HGMD): ADAMTSL2

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    Disorders / Diseases
    for ADAMTSL2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ADAMTSL2 for disorders           About GeneDecksing

    OMIM gene information: 612277   
    OMIM disorders: 231050  
    UniProtKB/Swiss-Prot: ATL2_HUMAN, Q86TH1
  • Defects in ADAMTSL2 are the cause of geleophysic dysplasia type 1 (GPHYSD1) [MIM:231050]. An autosomal
    • recessive disorder characterized by severe short stature, short hands and feet, joint limitations, and skin
    thickening. Radiologic features include delayed bone age, cone-shaped epiphyses, shortened long tubular bones, and
    ovoid vertebral bodies. Affected individuals have characteristic facial features including a 'happy' face with full
    cheeks, shortened nose, hypertelorism, long and flat philtrum, and thin upper lip. Other distinctive features include
    progressive cardiac valvular thickening often leading to an early death, toe walking, tracheal stenosis, respiratory
    insufficiency, and lysosomal-like storage vacuoles in various tissues

    5 diseases for ADAMTSL2:    About MalaCards
    geleophysic dysplasia    weill-marchesani syndrome    tracheal stenosis    short stature
    brachydactyly

    3 diseases from the University of Copenhagen DISEASES database for ADAMTSL2:
    Weill-Marchesani syndrome     Tracheal stenosis     Brachydactyly
    GeneTests: ADAMTSL2
    Geleophysic Dysplasia


    Export disorders for ADAMTSL2 gene to outside databases

    Publications
    for ADAMTSL2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ADAMTSL2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ADAMTSL2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
    2. Molecular screening of ADAMTSL2 gene in 33 patients reveals the genetic heterogeneity of geleophysic dysplasia. (PubMed id 21415077)1, 2 Allali S.... Cormier-Daire V. (2011)
    3. ADAMTSL2 mutations in geleophysic dysplasia demonstrate a role for ADAMTS-like proteins in TGF-beta bioavailability regulation. (PubMed id 18677313)1, 2 Le Goff C....Cormier-Daire V. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases. (PubMed id 14667842)1, 3 Hall N.G....Apte S.S. (2003)
    6. ADAMTS-like 2 (ADAMTSL2) is a secreted glycoprotein that is widely expressed during mouse embryogenesis and is regulated during skeletal myogenesis. (PubMed id 17509843)1 Koo B.H....Apte S.S. (2007)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)2 Humphray S.J.... Dunham I. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    9. Geleophysic Dysplasia (PubMed id 20301776)1 Cormier-Daire V. and Le Goff C. (1993)

    External Searches for ADAMTSL2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    Genome Databases showing ADAMTSL2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9719 HGNC: 14631 AceView: KIAA0605 Ensembl:ENSG00000197859 euGenes: HUgn9719
    ECgene: ADAMTSL2 H-InvDB: ADAMTSL2

    Other Databases showing ADAMTSL2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0605

    Specialized Databases showing ADAMTSL2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ADAMTSL2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ADAMTSL2

    Intellectual Property
    for ADAMTSL2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ADAMTSL2 gene:
    Search GeneIP for patents involving ADAMTSL2

    GeneCards and IP:
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