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ADAMTSL1 Gene

protein-coding   GIFtS: 53
GCID: GC09P018464

ADAMTS-Like 1

(Previous name: chromosome 9 open reading frame 94)
(Previous symbol: C9orf94)
  See ADAMTSL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADAMTS-Like 11 2     PUNCTIN2
C9orf941 2 3     ADAM-TS Related Protein 12
ADAMTSL-12 3     ADAMTS-Like Protein 12
ADAMTSR12 3     punctin-12
Chromosome 9 Open Reading Frame 941     Punctin-13
punctin1     

External Ids:    HGNC: 146321   Entrez Gene: 929492   Ensembl: ENSG000001780317   OMIM: 6091985   UniProtKB: Q8N6G63   

Export aliases for ADAMTSL1 gene to outside databases

Previous GC identifers: GC09P018952 GC09P018811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ADAMTSL1 Gene:
This gene encodes a secreted protein and member of the ADAMTS (a disintegrin and metalloproteinase with
thrombospondin motif) family. This protein lacks the metalloproteinase and disintegrin-like domains, which are
typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This
protein may have important functions in the extracellular matrix. Alternative splicing results in multiple
transcript variants encoding distinct proteins. (provided by RefSeq, Jul 2008)

GeneCards Summary for ADAMTSL1 Gene:
ADAMTSL1 (ADAMTS-like 1) is a protein-coding gene. Diseases associated with ADAMTSL1 include quebec platelet disorder, and colonic disease. GO annotations related to this gene include metallopeptidase activity. An important paralog of this gene is ADAMTSL4.

Gene Wiki entry for ADAMTSL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ADAMTSL1 gene promoter:
         COUP-TF1   USF1   COUP   HNF-4alpha2   HNF-4alpha1   RORalpha1   FAC1   COUP-TF   USF-1   IRF-7A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidADAMTSL1 promoter sequence
   Search Chromatin IP Primers for ADAMTSL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ADAMTSL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p21.3   Ensembl cytogenetic band:  9p22.2   HGNC cytogenetic band: 9p21.3

ADAMTSL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ADAMTSL1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P018464:  view genomic region     (about GC identifiers)

Start:
18,473,892 bp from pter      End:
18,910,948 bp from pter
Size:
437,057 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ATL1_HUMAN, Q8N6G6 (See protein sequence)
Recommended Name: ADAMTS-like protein 1 precursor  
Size: 1762 amino acids; 193409 Da
Subunit: Monomer
Mass spectrometry: Mass=61935; Mass_error=595; Method=MALDI; Range=28-525 (Q8N6G6-1); Source=PubMed:11805097;
Caution: Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and
disintegrin-like domains which are typical of that family
Sequence caution: Sequence=AAI00789.1; Type=Frameshift; Positions=1312; Sequence=AAI00791.1; Type=Frameshift;
Positions=1312; Sequence=AAK34948.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6PVN1 A8K7E1 Q496M6 Q496M8 Q5T708 Q5VZT8 Q8NAI9 Q96RW4 Q9BXY3
Alternative splicing: 6 isoforms:  Q8N6G6-3   Q8N6G6-1   Q8N6G6-2   Q8N6G6-4   Q8N6G6-5   Q8N6G6-6   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for ADAMTSL1: NX_Q8N6G6

Explore proteomics data for ADAMTSL1 at MOPED

Post-translational modifications: 

  • C-, N- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus
    sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine
    residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a
    beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of
    ADAMTSL1. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the
    consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate
    secretion1
  • Disulfide bonds are present1
  • Glycosylation2 at Trp39, Trp42, Thr48, Asn251, Thr312, Ser391, Thr451
  • Modification sites at PhosphoSitePlus

  • See ADAMTSL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035362.3  NP_443098.3  

    ENSEMBL proteins: 
     ENSP00000369921   ENSP00000327887   ENSP00000401157   ENSP00000369944   ENSP00000369940  
     ENSP00000276935   ENSP00000369918   ENSP00000440472   ENSP00000373362   ENSP00000369911  
    Reactome Protein details: Q8N6G6

    ADAMTSL1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ADAMTSL1

     
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    antibodies-online proteins for ADAMTSL1 (4 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ISET: Immunoglobulin superfamily / I-set domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR000884 Thrombospondin_1_rpt
     IPR010909 PLAC
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q8N6G6

    ProtoNet protein and cluster: Q8N6G6

    UniProtKB/Swiss-Prot: ATL1_HUMAN, Q8N6G6
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 PLAC domain
    Similarity: Contains 9 TSP type-1 domains


    Find genes that share domains with ADAMTSL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004222metalloendopeptidase activity ----
    GO:0005515protein binding ----
    GO:0008233peptidase activity ----
    GO:0008237metallopeptidase activity IEA--
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with ADAMTSL1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ADAMTSL1:
     Decreased POU5F1-GFP protein e 

         1 MGI phenotypic allele for Adamtsl1 (no phenotypes)

    Find genes that share phenotypes with ADAMTSL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Adamtsl1tm1Lex for ADAMTSL1

       genOway: Develop your customized and physiologically relevant rodent model for ADAMTSL1

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAMTSL1 (see all 44):
    hsa-miR-21* hsa-miR-4328 hsa-miR-513a-5p hsa-miR-25 hsa-miR-3916 hsa-miR-4325 hsa-miR-3613-3p hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidADAMTSL1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ATL1_HUMAN, Q8N6G6: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane2
    lysosome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005578proteinaceous extracellular matrix IEA--
    GO:0031012extracellular matrix ----

    Find genes that share ontologies with ADAMTSL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ADAMTSL1 About    
    See pathways by source

    SuperPathContained pathways About
    1Notch Signaling Pathway (sino)
    Notch Signaling Pathway


    Find genes that share SuperPaths with ADAMTSL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Sino Biological Pathway for ADAMTSL1
        Notch Signaling Pathway

    1 Reactome Pathway for ADAMTSL1
        O-glycosylation of TSR domain-containing proteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ADAMTSL1
    Interactions:

        Search GeneGlobe Interaction Network for ADAMTSL1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ADAMTSL1 (ATL1)

    1 HMDB Compound for ADAMTSL1    About this table
    CompoundSynonyms CAS #PubMed Ids
    3-O-Sulfogalactosylceramide (d18:1/24:0)Sulfatide (d18:1/24:0) (see all 16)151122-71-31527055

    Selected Novoseek inferred chemical compound relationships for ADAMTSL1 gene (see all 84)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fibrinogen 67.5 89 12351391 (6), 11939312 (3), 8652809 (3), 12913789 (2) (see all 60)
    heparin 61.6 61 1497347 (5), 1557410 (5), 8490019 (2), 8227183 (2) (see all 39)
    grgds 60.7 2 9426405 (1), 10192429 (1)
    procollagen 59 4 7958919 (1), 15135140 (1), 18084737 (1), 18790648 (1)
    antistasin 49.8 1 2303431 (1)
    heparan sulfate 49.3 8 1279952 (2), 8891889 (1), 15748207 (1), 18219588 (1) (see all 6)
    vegf 48.8 19 14517432 (2), 9136993 (2), 12539174 (1), 18443598 (1) (see all 16)
    sulfatide 45.8 3 2393863 (2), 1557410 (1)
    fucoidan 40.5 2 1802722 (2)
    dextran sulfate 40.4 1 8939794 (1)



    Find genes that share compounds with ADAMTSL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ADAMTSL1 gene (4 alternative transcripts): 
    NM_139238.1  NM_139264.1  NM_001040272.5  NM_052866.4  

    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380548(uc003zne.4 uc003znf.4) ENST00000327883(uc003znc.4)
    ENST00000431052 ENST00000380570 ENST00000380566(uc003znb.3) ENST00000276935
    ENST00000546040 ENST00000380559 ENST00000496521 ENST00000380545 ENST00000542621
    ENST00000388710 ENST00000380538 ENST00000489062(uc003zng.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ADAMTSL1 (see all 44):
    hsa-miR-21* hsa-miR-4328 hsa-miR-513a-5p hsa-miR-25 hsa-miR-3916 hsa-miR-4325 hsa-miR-3613-3p hsa-miR-889
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      QuantiTect SYBR Green Assays in human, mouse, rat ADAMTSL1
      QuantiFast Probe-based Assays in human, mouse, rat ADAMTSL1

    Selected AceView cDNA sequences (see all 41):

    AI825646 BC030262 AF251058 NM_139238 AW137913 BX113912 AI342006 NM_052866 
    BF932251 N44869 BM476141 BF111214 BI523618 BF510853 BQ005983 BQ007587 
    BE888902 BF058634 NM_139264 AY358327 BM555663 BF445136 W47029 CD636820 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ADAMTSL1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
    SP1:                          -                                 
    SP2:                    -     -                                 
    SP3:                                                            


    ECgene alternative splicing isoforms for ADAMTSL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ADAMTSL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTATTTAT
    ADAMTSL1 Expression
    About this image


    ADAMTSL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    ADAMTSL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ADAMTSL1 Protein Expression

    UniProtKB/Swiss-Prot: ATL1_HUMAN, Q8N6G6
    Tissue specificity: Expressed primarily in adult skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ADAMTSL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Adamtsl11 , 5 ADAMTS-like 11, 5 86.68(n)1
    91.86(a)1
      4 (40.32 cM)5
    777391  NM_029967.31  NP_084243.31 
     860539155 
    chicken
    (Gallus gallus)
    Aves ADAMTSL11 ADAMTS-like 1 74.64(n)
    78.97(a)
      431603  XM_004949124.1  XP_004949181.1 
    lizard
    (Anolis carolinensis)
    Reptilia ADAMTSL16
    ADAMTS-like 1
    78(a)
    1 ↔ 1
    2(62724064-63050968)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia adamtsl11 ADAMTS-like 1 67.33(n)
    70.79(a)
      100494603  XM_004910864.1  XP_004910921.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CABZ01112436.16
    Uncharacterized protein
    14(a)
    many ↔ many
    Zv9_NA786(408-22627) ENSDARG00000091844
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316196
    --
    28(a)
    1 → many
    2L(21684103-21729051)
    worm
    (Caenorhabditis elegans)
    Secernentea madd-46
    Protein MADD-4, isoform c
    20(a)
    many ↔ many
    I(8931035-8942287) WBGene00009958


    ENSEMBL Gene Tree for ADAMTSL1 (if available)
    TreeFam Gene Tree for ADAMTSL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ADAMTSL1 gene
    ADAMTSL42  ADAMTS72  ADAMTS132  ADAMTS122  THSD42  ADAMTSL22  PAPLN2  ADAMTSL52  
    ENSG000002156162  ADAMTSL32  
    9 SIMAP similar genes for ADAMTSL1 using alignment to 5 protein entries:     ATL1_HUMAN (see all proteins):
    C9orf94    ADAMTSL3    ADAMTS3    ADAMTS5    ADAMTS16    ADAMTS20
    MUSK    PAPLN    ADAMTSL5

    Find genes that share paralogs with ADAMTSL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ADAMTSL1 (see all 11150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1833667071,2
    --18472326(+) ATACGC/GTTTAG 2 -- us2k10--------
    rs1880606961,2
    --18472488(+) TTTGTA/GTGACC 2 -- us2k10--------
    rs760269431,2
    C,F--18472511(+) ACAGCA/TTGAAA 2 -- us2k14Minor allele frequency- T:0.10NA CSA WA 242
    rs105116381,2
    C,F,H--18472546(-) ATCAAT/CTAAAG 2 -- us2k116Minor allele frequency- C:0.07NS EA NA CSA WA 908
    rs1422207861,2
    --18472588(+) ACAACA/CTGCTT 2 -- us2k10--------
    rs1932640941,2
    --18472618(+) GCAACA/GCAGCA 2 -- us2k10--------
    rs1841255291,2
    --18472741(+) AAGAAC/TATTAA 2 -- us2k10--------
    rs1512337771,2
    --18472752(+) TTCTAA/CATGTC 2 -- us2k10--------
    rs1134042741,2
    C,F--18472846(+) AGGCCA/GGGGCT 2 -- us2k13Minor allele frequency- G:0.09CSA WA 122
    rs1879571611,2
    --18472986(+) GGTGGA/TTTAAG 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ADAMTSL1 (18473892 - 18723892 bp, first 250kb of ADAMTSL1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ADAMTSL1 (see all 36):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2738255CNV Deletion23290073
    esv2611468CNV Deletion19546169
    esv1945859CNV Deletion18987734
    esv1006882CNV Deletion20482838
    esv1386680CNV Deletion17803354
    esv2262298CNV Deletion18987734
    esv998276CNV Deletion20482838
    esv2678130CNV Deletion23128226
    esv4320CNV Deletion18987735
    esv2738253CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609198    OMIM disorders: --

    3 diseases for ADAMTSL1:    
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    quebec platelet disorder    colonic disease    malaria


    Find genes that share disorders with ADAMTSL1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ADAMTSL1 gene (see all 83)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    psach 73.9 1 11691584 (1)
    quebec platelet disorder 69.6 2 8652809 (2)
    malaria cerebral 59.2 2 12563735 (1)
    purpura thrombotic thrombocytopenic 51 3 19786614 (1), 18828196 (1), 18957966 (1)
    sickle cell disease 43.5 1 8656036 (1)
    neovascularization 42.5 2 1697685 (1), 15250170 (1)
    malaria 40.9 7 10697897 (2), 2204833 (1), 15003842 (1), 17762778 (1) (see all 5)
    melanoma 39 26 2393863 (5), 1557410 (4), 8925881 (3), 7599038 (2) (see all 11)
    von willebrand disease 36.8 1 14525793 (1)
    malaria falciparum 34.1 2 8798390 (1), 8702026 (1)

    Genetic Association Database (GAD): ADAMTSL1
    Human Genome Epidemiology (HuGE) Navigator: ADAMTSL1 (5 documents)

    Export disorders for ADAMTSL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ADAMTSL1 gene, integrated from 10 sources (see all 676):
    (articles sorted by number of sources associating them with ADAMTSL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. (PubMed id 11805097)1, 2, 3, 9 Hirohata S.... Apte S.S. (J. Biol. Chem. 2002)
    2. Post-translational modification of thrombospondin type-1 repeats in ADAMTS-like 1/punctin-1 by C-mannosylation of tryptophan. (PubMed id 19671700)1, 2, 9 Wang L.W.... Apte S.S. (J. Biol. Chem. 2009)
    3. O-fucosylation of thrombospondin type 1 repeats in ADAMTS-like- 1/punctin-1 regulates secretion: implications for the ADAMTS superfamily. (PubMed id 17395588)1, 2, 9 Wang L.W....Apte S.S. (J. Biol. Chem. 2007)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Association and interaction analyses of eight genes under asthma linkage peaks. (PubMed id 19824886)1, 4 Ferreira M.A....Duffy D.L. (Allergy 2009)
    7. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (Nature 2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 92949 HGNC: 14632 AceView: ADAMTSL1 Ensembl:ENSG00000178031 euGenes: HUgn92949
    ECgene: ADAMTSL1 H-InvDB: ADAMTSL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ADAMTSL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ADAMTSL1 gene:
    Search GeneIP for patents involving ADAMTSL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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